Digital Commons Network^™

Utilizing A Culture System For Horizontal Cells To Study Neural Circuit Assembly In The Developing Mouse Retina, Ross M Perez, Yong H Park, Ajeet Singh, Collin Todora, Marlon F Mattos, Daniela Becerril, Rajashree Venkatraman, Arlene A Hirano, Nicholas C Brecha, Rinki Ratnapriya, Benjamin J Frankfort, Elizabeth Zuniga-Sanchez

Faculty, Staff and Students Publications

The precise wiring of the nervous system relies on neurons extending their processes at the right time and place to find their appropriate synaptic partner. The mechanisms that determine when and where neurons extend their neurites during synaptogenesis remains a central question in the field. In the present study, we used a cell culture system coupled with live imaging to investigate the wiring mechanisms in the developing mouse retina. We focused on horizontal cells which are a class of interneurons in the outer mouse retina known to synapse selectively to the distinct types of photoreceptors. Previous research has shown horizontal …

Using Lotilaner Ophthalmic Solution, 0.25% To Treat Demodex Blepharitis In Patients Who Were Initially Misdiagnosed: A Case Series, Laura M Periman, Richard Lindstrom, Paul Karpecki, Brandon Ayres, Eric Donnenfeld, Marjan Farid, Ian Benjamin Gaddie, Preeya K Gupta, Selina Mcgee, Kelly K Nichols, Stephen Pflugfelder, Christopher E Starr, Nandini Venkateswaran, Elizabeth Yeu, Cecelia Koetting

Faculty, Staff and Students Publications

Introduction: Demodex blepharitis (DB) is a chronic ocular inflammation caused by Demodex mite infestation of the eyelid. DB is often misdiagnosed, as some of its clinical findings and patient-reported outcomes overlap with those of other ocular surface diseases. The Demodex Expert Panel on Treatment and Eyelid Health (DEPTH) has reached consensus on the symptomatology, diagnosis, and treatment of DB. Consensus findings from the DEPTH group include that collarettes are pathognomonic for DB and that lotilaner ophthalmic solution, 0.25%, the first and only FDA-approved treatment for DB, should be the first-line treatment for the disease. This case series highlights two instances …

Non-Congenital Hsv-1 Keratitis In An Immunocompetent 9-Month-Old Infant, Caleb A Casanova, Stephanie Trejo Corona, Stephen F Pflugfelder

Faculty, Staff and Students Publications

Isolated, non-congenital herpes simplex virus type 1 (HSV-1) keratitis in immunocompetent infants is exceedingly rare and may be easily misdiagnosed, leading to delays in appropriate antiviral therapy. This case is unique in that it describes HSV-1 keratitis in a healthy 9-month-old infant presenting without systemic illness, initially treated as bacterial conjunctivitis. The patient presented with unilateral eye pain, redness, and corneal opacification. Subsequent evaluation revealed HSV-1 keratitis, and the patient was treated with intravenous acyclovir in combination with topical moxifloxacin and topical ganciclovir, resulting in complete resolution of symptoms within one week. This case adds to the limited literature on …

Updates In Mycobacterial Keratitis Diagnosis And Treatment, Uma L Balakrishnan, Ryan T Wallace, Patricia Chévez-Barrios, Alejandro Arboleda, Masih U Ahmed

Faculty, Staff and Students Publications

Mycobacterial keratitis is an uncommon but challenging form of infectious keratitis, often associated with postsurgical eyes. Clinical presentation is variable and may be difficult to recognize, resulting in delays in diagnosis and challenges in management. Traditional diagnostic techniques from corneal scrapings are limited by slow organism growth and may yield negative results. Treatment is challenging due to antimicrobial resistance and typically requires prolonged multidrug therapy. Advances in diagnostic modalities, antimicrobial therapies, surgical approaches, and adjunctive treatments such as corneal crosslinking have improved clinicians' ability to mitigate or avoid severe visual consequences. Despite these developments, optimal management strategies remain incompletely defined, …

Common And Recurrent Dysregulated Molecular Network Of Placental Hypoxia And Associated Vasculogenesis And Angiogenesis In Fetal Growth Restriction, Wei Li, Xiaoyi Bai, Oi Ka Chan, Maran Bo Wah Leung, So Ling Lau, Chi Chiu Wang, Tak Yeung Leung

Faculty, Staff and Students Publications

Fetuses with fetal growth restriction (FGR) and selective FGR (sFGR) face elevated health risks both before and after birth. Although the underlying pathomechanisms remain unclear, placental dysfunction is recognized as a major contributing factor. By integrating untargeted transcriptomic data from FGR/sFGR placentae, this study identified 69 differentially expressed mRNAs (DEmRs) and eight differentially expressed miRNAs (DEmiRs). Functional enrichment analysis demonstrated significant enrichment in the angiogenesis and vasculogenesis pathways, with the hypoxia-related genes

The Rise Learning Theory: A New Paths-Way For Teaching Social Emotional Learning Curricula, Rebecca L. Demeo

Scripps Senior Theses

This study aims to look at the effectiveness of the Promoting Alternative THinking Strategies (PATHS) Social Emotional Learning curriculum when taught through the second and fourth principles of the RISE learning theory. The implementation will take effect within United States elementary schools, and consenting students will participate in the quasi-experimental design where classrooms will either be assigned to the control group, PATHS program taught as normal, or the experiment, PATHS taught with the RISE principles. During the study, participants will complete pre-experiment, post-experiment, and follow-up assessments to measure differences in mean scores of competence and application throughout the implementation. I …

"Chatcbt”: Understanding The Implications Of Artificial Intelligence In Cognitive Behavioral Therapy, Esther R. Goldberg

Scripps Senior Theses

The proposed study is intended to explore the impacts of artificial intelligence (AI) tools when used in cognitive behavioral therapy (CBT) to treat anxiety in American adults. The research is designed to measure whether AI systems such as large language models (LLMs) provide sufficient therapy through the factors of empathy, coping skills, and anxiety symptom reduction. Human therapists are hypothesized to surpass chatbots in all three. Through an experimental design, participants will be placed in either an AI therapy condition or human therapy condition. Participants will undergo a 12-week CBT program, after which they will measure anxiety reduction, perceived empathy …

Roots To Recovery: How Therapeutic Horticulture Can Heal Sexual Trauma, Fiona E. Larsen-Teskey

Scripps Senior Theses

Sexual assault is one of the most prevalent sources of trauma among females. While still requiring more research, therapeutic horticulture (TH), also known as gardening therapy, has so far shown promising results regarding trauma recovery. In this study, I seek to discover how TH can aid in female sexual assault recovery. To determine its impact, I will conduct a three-month experiment with two groups: those who receive cognitive behavioral therapy (CBT) and those who receive CBT plus TH. I will specifically measure three common side effects survivors face: dissociation, shame, and PTSD. These categories will be measured through surveys and …

Pervasive Policing: The Psychological Effects Of Overcriminalization Of Black And Latino Youth, Chloe Gonzalez

Scripps Senior Theses

Recent years have brought increased awareness to the discriminatory treatment of Black and Latino individuals by the police, but a gap in the literature remains at the intersection of the study of criminalization and psychology. The proposed study will attempt to bridge this gap by investigating the extent to which the overcriminalization of Black and Latino high schoolers contributes to the internalization of racialized stereotypes and the development of depressive symptoms. The research will implement a correlational approach combining quantitative and qualitative methods to gather data from a sample of Black and Latino high schoolers ages 14 to 18. Participants …

Art Therapy’S Effect On The Social And Emotional Skills Of Children With Autism: A Naturalized Parent Mediated Design, Abigail Adell

Scripps Senior Theses

This study examines the effect of art therapy on the social and emotional skills of children with autism. Using sensitive design and language, participants will take the CARS2 and ADOS-2 and then undergo an eight-week art therapy program. Families will attend weekly training sessions at the autism center their child already attends for eight consecutive weeks, with each session lasting approximately 90 minutes. Parents will implement the assigned art activity at home five times per week between training sessions, with each home session lasting fifteen to twenty minutes. The program uses a naturalized parent-mediated design so topics and projects can …

Boredom And Creativity: The Effects Of Unstructured Play Versus Screen Time On Creative Performance, Vivienne J. Swenson

Scripps Senior Theses

Children today spend increasing amounts of time engaged with digital media, raising questions about how screens may displace developmental experiences that support creativity. Although research suggests that unstructured play and even mild boredom can facilitate divergent thinking, few studies have directly compared unstructured, self-directed play with passive screen use in early childhood. The present study proposes an experimental design to examine whether 20 minutes of unstructured play leads to higher creativity scores on the Thinking Creatively in Action and Movement (TCAM) than an equivalent period of passive screen engagement among children ages 3–5. Using matched-group assignment based on demographic, cognitive, …

Bilingual Beginnings: Expressive Language And Socio-Emotional Development In Early Childhood, Molly C. Mccormick

Scripps Senior Theses

Although research on bilingualism has expanded rapidly in recent years, the majority focuses on cognitive advantages or receptive vocabulary, or the words children understand. Far less attention has been given to how expressive language, the words children produce, and its potential role as the mechanism linking bilingual exposure to socio-emotional development. Although dual-language learners sometimes appear to have relatively limited expressive vocabularies in one language, these differences tend to reflect patterns of language use and input quality rather than true developmental delays. Even so, temporary differences in expressive skills can be especially meaningful during children’s formative years, when they rely …

Resilience As A Pathway From Openness To Eustress In College Students, Karis H. Choi

Scripps Senior Theses

College students experience high levels of stress, yet not all stress leads to negative outcomes. This study examines how personality and coping resources contribute to eustress—a positive, motivating form of stress—by investigating whether resilience mediates the relationship between openness to experience and eustress. Undergraduate participants completed baseline measures of openness and resilience before engaging in either a high-demand mental arithmetic task or a low-demand control task. Following the task, participants reported their emotional and behavioral responses using the Measure of Emotional, Physical, and Behavioral Markers of Eustress and Distress (MEDS). Consistent with expectations, individuals higher in openness were predicted to …

Exploring The Moderating Role Of Ethnic Identity In Asian American Multi-Ethnic Youths’ Sense Of Purpose And Life Satisfaction, Grace Cheung

Scripps Senior Theses

The rapid increase of interracial and interethnic families globally creates a need for researchers to understand the unique experiences and development of multi-ethnic youths’ sense of identity and purpose as they relate to well-being. Emerging research in Asian American psychology also suggests the urgency and need to reexamine the experiences of individual ethnic groups. The current study will examine the moderating role of ethnic identity in Asian American multi-ethnic youths’ sense of purpose and life satisfaction through a mixed methods approach that includes an online survey followed by an interview for a subgroup of participants. Anticipated results will show how …

An Analysis Of Eating Disorders As A Comorbidity Of Autoimmune Diseases, Madeleine Shore

Scripps Senior Theses

For many autoimmune disease patients, psychiatric conditions are a common comorbidity. Although there are many shared mechanisms between autoimmune disease and psychiatric conditions, current research surrounding mental health among autoimmune disease patients often focuses on mood disorders rather than eating disorders. Despite the high risk for developing psychiatric conditions, most autoimmune disease patients are not screened for eating disorders. This lack of screening is significant, because if an eating disorder is missed by a healthcare provider, the autoimmune or eating disorder condition could be exacerbated, resulting in severe illness or even fatality. Given an existing link between comorbid psychiatric disorders, …

Effects Of Teacher Training On Identifying Inattentive Type Adhd In Afab Students, Gabrielle A. Boles

Scripps Senior Theses

Teachers are more likely to detect hyperactive ADHD symptoms than inattentive ones, which often results in students, especially girls with inattentive symptoms, being under-referred (Willcut, 2012). This study evaluates whether a targeted, inattentive-focused, and gender responsive teacher training reduces gendered and symptom-based biases in referral decisions. K-5 teachers will be randomly assigned to receive either standard general ADHD identification training or an inattentive-focused, gender-responsive training, and will then be asked to review vignettes depicting children with hyperactive and inattentive symptoms, with varying student genders. Referral accuracy and knowledge of ADHD will be measured. Training condition, symptom presentation, and student gender …

Assessing Diagnostic Overshadowing For Co-Occurring Autism Spectrum Disorder (Asd) And Eating Disorders (Ed), Eden Sweet

Scripps Senior Theses

Significant behavioral overlaps in feeding patterns are observed among individuals with eating disorders (EDs) and autism spectrum disorder (ASD). These behavioral similarities can blur diagnostic boundaries, contribute to diagnostic overshadowing, and consequently increase the risk of misdiagnosis and the implementation of ineffective treatment approaches. The proposed study addresses the risk of diagnostic overshadowing as it relates to the ambiguous distinction between autism-driven feeding behaviors and clinically significant eating disorders (ED) within the autistic population. Although the literature has acknowledged behavioral similarities between ASD and EDs, limited research has systematically examined how they impact diagnostic practices and influence the likelihood of …

The Effects Of The Opioid Crisis On Contraceptive Decisions And Fertility In Pakistan, Simren R. Khan

Scripps Senior Theses

This paper examines how the opioid epidemic influences household fertility behavior in Pakistan by analyzing contraceptive use and fertility outcomes across regions with differing levels of opioid prevalence. Using household-level data from the 2017–18 Pakistan Demographic and Health Survey (DHS) and estimating OLS regression models, the study compares households in high-prevalence regions with those in low-prevalence regions. The results show that exposure to high-opioid regions is associated with lower fertility outcomes and a higher likelihood of respondents wanting their last child. These patterns suggest that households may respond to opioid-related economic and caregiving burdens by limiting family size and treating …

The Economics Of Accountability: Learning From German Holocaust Reparations, Grace I. Gates

Scripps Senior Theses

Drawing on microdata from the Survey of Health, Aging, and Retirement in Europe, this study compares European Holocaust survivors who received reparations with similar Europeans who did not. It finds that, decades on, recipients are not systematically better or worse off on core outcomes like life satisfaction, savings, and debt. This is consistent with the argument that reparations restore parity rather than create new advantages. Where differences emerge, they point to stabilization in more vulnerable settings (e.g., lower likelihood of high debt in parts of Eastern Europe). The main takeaway from effective reparations is applicable to the United States debate: …

Assessing Elemental Composition In Dry, Canned, And Fresh Dog Food Using Icp-Oes And Xrf Analysis, Lyla M. Johnston

Scripps Senior Theses

Pet food safety has become a concern due to recurring contamination incidents and limited federal regulation of toxic metal concentrations. This study investigates the elemental composition of 15 commercial dog and cat foods. Representing dry, canned, and fresh dog food types, using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) and portable X-Ray Fluorescence (XRF) analysis. The primary objective was to quantify concentrations of potentially harmful heavy metals (Cr, Pb, As, Hg, Cd) and assess the presence of abundant elements such as aluminum (Al), silicon (Si), and sodium (Na). All five target heavy metals were below instrument detection limits, suggesting that …

Photographic Perceptions: Reconstructing The Life And Career Of Dody Weston Thompson, Virginia Carroll

Scripps Senior Theses

This thesis reconstructs the life and career of photographer Dody Weston Thompson (1923-2012), presenting a narrative that has been absent from photographic history. Dody trained beneath significant figures like Edward Weston and Josef Albers, exhibited among some of the most canonical figures in photographic history, and served as a founding member of Aperture magazine—one of the foremost photographic journals to this day. Despite this, there has been no academic scholarship on Dody’s life or career, leaving her largely absent from the art-historical record.

Through the analysis of The Dody Weston Papers at the Ella Strong Denison Library and photographs held …

Mindfulness As A Potential Facilitator Of Self-Forgiveness?, Isabella S. Lindsay Castelli

Scripps Senior Theses

Despite clinicians’ attestation to self-forgiveness’ relevance in clinical practice, as well as research suggesting its positive relationship to well-being, most clinicians are not familiar with models for facilitating self-forgiveness. The present study draws on theoretical overlap between mindfulness theory and three prominent models of the self-forgiveness process, as well as empirical research showing a positive association between dispositional mindfulness and dispositional self-forgiveness. Participants were adults in the United States, randomly assigned to a mindfulness exercise or control (progressive muscle relaxation exercise). Participants were asked to think of a transgression they committed, report their self-forgiveness for that transgression, and retake the …

The Silent Language Of Trauma: Defendant Behavior, Juror Bias, And Expert Testimony, Jensen Goldman

Scripps Senior Theses

Trauma can profoundly influence behavioral presentation, yet jurors often rely on demeanor as a diagnostic cue for guilt, credibility, and remorse. Such reliance poses risks within a legal system that seldom equips jurors to interpret trauma related behaviors accurately. The proposed study will examine how two trauma-linked affective presentations– overemotionality and flat affect– shape juror perceptions of credibility and guilt, and whether expert psychological testimony about trauma-related affect can mitigate these biases. Online survey participants will read one of five trial vignettes with varying defendant conditions (flat affect vs. overemotional) and varying expert testimony conditions (present or not present) and …

Transition To Tenecteplase Is Associated With Shorter Door-To-Puncture Times: A Retrospective Study From The Lone Star Stroke Consortium Tnk Registry, Anqi Luo, Sujani Bandela, Gretchel Gealogo-Brown, Mark P Goldberg, Andrew Slusher, Reza Behrouz, Alibay Jafarli, Siddarth Prasad, Daiwai Olson, Maria Denbow, Mehari Gebreyohanns, Asmiet Techan, Chethan P Venkatasubba Rao, Jane A Anderson, Barbara Kimmel, Anette Ovalle, Michele Patterson, Sean I Savitz, Salvador Cruz-Flores, Steven Warach, Lee Birnbaum

Faculty, Staff and Students Publications

Background: Intravenous thrombolytic (IVT) and mechanical thrombectomy (MT) therapies are the current standard of care for large vessel occlusion (LVO) stroke. Multiple studies emphasized the impact of time metrics on patient outcomes, particularly door-to-needle (DTN) and door-to-puncture (DTP) times. Tenecteplase (TNK) offers potential advantages over alteplase (ALT), including a simplified one-time bolus administration, which may reduce DTP time. Results suggest TNK is non-inferior to ALT in terms of clinical outcomes, but few large cohort studies have compared DTP time for patients receiving TNK vs. ALT prior to thrombectomy. This real-world study aimed to compare DTP times and discharge outcomes in …

Proceedings Of The 13th Annual Deep Brain Stimulation Think Tank: The Evolving Landscape, Chance R Fleeting, Eduardo M Moraud, Kamil Uğurbil, Doris D Wang, Wolf-Julian Neumann, Andrea A Kühn, Valerie Voon, Victor Pikov, Marie-Laure Welter, Michael D Fox, John D Rolston, Mahsa Malekmohammadi, Yagna J Pathak, Lyndahl M Himes, David Greene, Abbey S Holt-Becker, Gabriel Lázaro-Muñoz, Alexander W Charney, Amanda R Merner, Martijn Figee, Katherine W Scangos, Timothy Denison, Kent Leyde, Aysegul Gunduz, Helen M Bronte-Stewart, James C Beck, Nora Vanegas-Arroyave, Marta San Luciano, Norbert Brüggemann, Kelly D Foote, Michael S Okun, Joshua K Wong

Faculty, Staff and Students Publications

The Deep Brain Stimulation (DBS) Think Tank XIII was held September 2-4th, 2025, in Gainesville, Florida, at the Norman Fixel Institute for Neurological Diseases at the University of Florida. The theme was "The Evolving Landscape of DBS: New Indications, New Goals." This theme was a continuation of the DBS Think Tank XI and XII, which were focused on emerging technology and pushing the horizon of indications. Since its founding in 2012, the DBS Think Tank has provided a global forum for leading clinicians, engineers, and researchers in both in industry and academia to present, discuss, and debate the current state …

Case Report: Molecular Diagnostics And Clinical Courses Of Two Adult Spinal Pilocytic Astrocytoma Long-Term Survivors With Gtf2i::Braf Fusion, Lorenzo Argao, Pinar E Zerk, Hsiang-Chih Lu, Zied Abdullaev, Martha Quezado, Michelle L Cassidy, Bennett Mclver, Anna Choi, Marissa Panzer, Renee Tweneboah-Koduah, Lily Polskin, Marta Penas-Prado, Paul Park, Nathan Clarke, Kenneth Aldape, Jacob Mandel, Byram H Ozer

Faculty, Staff and Students Publications

Introduction: Pilocytic astrocytomas are driven by BRAF and mitogen-activated protein kinase (MAPK) alterations, typically KIAA1549::BRAF fusions. A rare GTF2I::BRAF fusion has been described, but little is known about these cases.

Case report: Here, we report two cases with GTF2I::BRAF fusions. Case 1 is a 36-year-old man initially diagnosed with myxopapillary ependymoma at the conus medullaris with three recurrences over 23 years requiring two surgeries, three rounds of radiation therapy, and one round of lapatinib/temozolomide. A distant disease focus in T3/T4 was sampled and tested with modern diagnostic techniques revealing a pilocytic astrocytoma on histology and methylation profiling. The patient has …

Suicidal Ideation In Spinocerebellar Ataxia, Levi Peppel, Ruo-Yah Lai, Christian Rummey, Puneet Opal, Jeremy D Schmahmann, Christopher M Gomez, Henry Paulson, Theresa A Zesiewicz, Susan Perlman, George Wilmot, Sarah H Ying, Chiadi U Onyike, Khalaf O Bushara, Michael D Geschwind, Karla P Figueroa, Stefan M Pulst, Sub H Subramony, Antoine Duquette, Tetsuo Ashizawa, Ali G Hamedani, Marie Y Davis, Sharan R Srinivasan, Matthew R Burns, Nadia Amokrane, Lauren R Moore, Vikram G Shakkottai, Liana S Rosenthal, Sheng-Han Kuo, Chi-Ying R Lin

Faculty, Staff and Students Publications

Objective: Suicidal ideation has not been extensively studied in spinocerebellar ataxias (SCAs). The authors examined whether individuals with SCAs have increased suicidal ideation and related factors.

Methods: The authors studied patients with genetically confirmed SCAs enrolled in the Clinical Research Consortium for the Study of Cerebellar Ataxia cohort, examining the percentages of patients with SCA subtypes 1, 2, 3, and 6 who reported suicidal ideation and comparing findings with nationally representative data from the National Survey on Drug Use and Health (NSDUH). Clinical characteristics that may contribute to suicidal ideation in SCAs, including age, disease duration, sex, ataxia severity, depression, …

A Balancing Act: Amyloid-Β, Tau, And Excitation-Inhibition In Alzheimer's Disease, Manuel Silva-Pérez, Jeannie Chin

Faculty, Staff and Students Publications

A growing body of evidence shows that epileptic activity is frequently observed in patients with Alzheimer's disease (AD), implicating underlying excitatory–inhibitory imbalance. The distinction of whether the AD-epileptic phenotype represents a subset of patients or an underdiagnosed manifestation holds major therapeutic implications. Here, we quantified the excitatory–inhibitory imbalance in AD patients using magnetoencephalography and examined the relationships to AD pathophysiology—amyloid-beta and tau, and to epileptic activity. We used two metrics to quantify regional excitatory–inhibitory imbalance distinguishing between local hyperexcitability (Neural excitability, quantified by regional aperiodic spectral slope) and aberrant long-range synaptic input integration (Neural fragility, quantified by …

Information Law Pluralism, Hannah Bloch-Wehba

Faculty Scholarship

Information-intensive activities are reshaping political, social, and economic institutions. As they respond to these shifts, legislators and regulators are embracing information as a regulatory device for tech. Far from limiting themselves to public disclosure, consumer notice, and other traditional mechanisms of fostering transparency and information flows, however, legislators are using other, more nuanced tools to incentivize regulated entities to obtain, generate, and share information.

This Article maps the landscape of the emerging information-based regimes for regulating tech and assesses their conceptual and practical implications. It canvasses an extensive set of recently enacted laws regulating the information economy and shows that, …

Equal Justice & Generative Ai, Milan R. Markovic

Faculty Scholarship

The United States has long suffered from unequal access to justice, with countless low-and middle-income Americans forced to navigate the legal system alone. Recently, prominent judges, lawyers, and scholars have seized on generative AI as a potential corrective. These techno-optimists maintain that ChatGPT and other large language models can demystify the law and address unmet legal needs. Chief Justice John Roberts has proclaimed that AI-based tools "have the welcome potential to smooth out any mismatch between available resources and urgent needs in our court system."

Although AI will be an increasingly important source of legal assistance for underserved populations, the …