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Phase I Study Of Niraparib With Radiotherapy For Treatment Of Metastatic And Locally Advanced Invasive Carcinoma Of The Cervix (Nivix), Piyush Pathak, Eunji Jo, Susan Hilsenbeck, Matthew L Anderson, Alfredo Echeverria, Shelly Sharma, Jan Sunde, Tracilyn Hall, Anthony Costales, Claire Hoppenot, Michelle Ludwig

Faculty, Staff and Students Publications

Introduction: This Phase I study evaluated the safety and tolerability of concurrent niraparib, an oral poly(ADP-ribose) polymerase (PARP) 1/2 inhibitor, with definitive radiotherapy in women with locally advanced or platinum-sensitive metastatic cervical cancer. Dose escalation followed a Bayesian Optimal Interval (BOIN) design with a target dose-limiting toxicity (DLT) rate of 30%.

Methods: Women ≥18 years with FIGO stage IIIC2 (bulky nodes >1 cm) or stage IV cervical cancer demonstrating response to platinum-based induction chemotherapy were eligible. Niraparib 100 mg was administered daily concurrent with pelvic radiotherapy (45-57.5 Gy via IMRT with nodal boosts) and brachytherapy, continuing 28 days post-radiation. Per …

Frontmatter (Volume 46, Issue 6), Paul B. Mojzes

Occasional Papers on Religion in Eastern Europe

No abstract provided.

Italian Missionary Activities In Georgia: Historical Legacy And Modern Inter-Religious Dialogue, Zaza Tsotniashvili

Occasional Papers on Religion in Eastern Europe

This article examines the historical development, cultural contributions, and contemporary significance of Italian missionary activities in Georgia spanning seven centuries, from medieval Catholic presence through the traumatic Soviet period to the post-independence revival. Drawing upon Georgian, Italian, and Vatican archival sources, including the manuscripts of Arcangelo Lamberti, Cristoforo de Castelli, and Michel Tamarati, the study provides comprehensive analysis of Italian Catholic missionaries' multifaceted engagement with Georgian society. The research demonstrates that Italian missionaries, particularly members of the Theatine, Capuchin, and Augustinian orders, played roles extending far beyond religious evangelization, functioning as diplomatic intermediaries, medical practitioners, linguistic documentarians, ethnographic observers, and …

Beyond Drugs And Surgery: Superselective Adrenal Artery Embolization Redefines Primary Aldosteronism Management-A Systematic Review And Meta-Analysis, Kimia Darmiani, Mehrad Zare, Alisa Mohebbi, Mohammad Mirza-Aghazadeh-Attari, Mohammad Ghasemi Rad, Afshin Mohammadi

Faculty, Staff and Students Publications

Background: Primary aldosteronism (PA) is a leading cause of secondary hypertension associated with increased cardiovascular and cerebrovascular risk. Superselective adrenal artery embolization (SAAE) has emerged as a minimally invasive alternative to adrenalectomy and mineralocorticoid receptor antagonists (MRAs). This systematic review and meta-analysis evaluates the efficacy and safety of SAAE in PA management.

Methods: We searched PubMed, Web of Science, Embase, and Cochrane Library through June 2026 for studies enrolling patients with PA treated by SAAE. Outcomes of interest were changes in blood pressure (BP), biochemical markers (serum potassium, aldosterone, renin activity, and aldosterone-to-renin ratio), clinical and biochemical response rates, daily …

Religious Transformation Of Crimea Amid Geopolitical Changes: From Pluralism To Totalitarian Control (2000–2026), Volodymyr Zuikov

Occasional Papers on Religion in Eastern Europe

This article analyzes the radical transformation of the religious landscape of the Crimean Peninsula in the context of geopolitical changes and “hybrid warfare.” I conduct a comparative analysis of two chronological periods: the stage of Ukrainian sovereignty from 2000 to 2013, which was characterized by a high level of religious pluralism and interconfessional peace, and the period of Russian occupation from 2014 to 2024/2026, which was marked by a transition to a rigid hierarchical system of control. The scholarly novelty of the study lies in its detailed reconstruction of the mechanisms of the “hybrid absorption” of Protestant communities, including Baptists, …

Marriage Governance In Kyrgyzstan: Convergence And Divergence Between Secular Law, Islamic Norms, And Customary Practices, Aisuluu Adylbekkyzy, Zailabidin Azhimamatov, Aiitmamat Kariev

Occasional Papers on Religion in Eastern Europe

Marriage governance in Kyrgyzstan is shaped by the coexistence of secular law, Islamic norms, and customary law), creating a plural legal environment in which multiple sources of authority regulate family relations. This study examines how these normative systems interact in the governance of marriage, identifies areas of convergence and divergence, and explores their implications for legal legitimacy and family regulation. Employing a qualitative socio-legal methodology grounded in legal pluralism theory, the research draws on documentary and comparative analysis of legal texts, Islamic sources, official religious guidance, and relevant scholarly literature. The findings demonstrate that marriage governance in Kyrgyzstan operates through …

Janusz Krupski And His Times: Moral Rearmament From A Historical And Religious Perspective, Christopher Garbowski

Occasional Papers on Religion in Eastern Europe

This paper explores the concept of moral rearmament in contemporary East-Central Europe through the historical and religious legacy of Polish anti-communist opposition figure Janusz Krupski (1951–2010). Responding to sociologist Frank Furedi’s critique regarding the "moral disarmament" of the West, the author contends that religion serves as an essential—and frequently overlooked—pillar in restoring historical consciousness and moral resilience against totalitarian and geopolitical threats.

Focusing on the unique intellectual ecosystem of the Catholic University of Lublin (KUL) during the communist regime, the article details Krupski’s pioneering role in establishing an underground publishing movement, most notably the independent Catholic journal Spotkania (Encounters …

The Phenomenon Of Existential Ecumenism In Contemporary Ukraine, Iryna Kondratieva, Andrii Marchenko, Oleksii Marchenko

Occasional Papers on Religion in Eastern Europe

An analysis of existential ecumenism as a dimension of inter-church unity, which is being formed in modern Ukraine due to a common existential threat from the Russian aggressor, when Ukrainian churches unite in an ecumenical response to war crimes, focusing on practical cooperation in real life, on the tasks of social service, and not on existing doctrinal or institutional differences. Existential ecumenism combines the main ideas of existential philosophy, with its emphasis on the value of the human person, the significance of the themes of human freedom and human choice in the face of meaninglessness and death, and ecumenism as …

Hybrid Identity And Religious Radicalization: On The Effectiveness Of Kazakhstan's State Policy, Sholpan Zhandossova, Marhabbat Nurov

Occasional Papers on Religion in Eastern Europe

This article examines the relationship between hybrid identity and religious radicalization in Kazakhstan, arguing that state policy has been built on a systematically inverted risk hierarchy. Drawing on secondary analysis of longitudinal sociological surveys, expert assessments, and official statistics, the article demonstrates that the intensity of religious practice is a statistically non-significant predictor of radicalization (ρ=+0.18; p>0.05), whereas identity fragmentation– the internal incoherence between competing ethnic, Soviet-secular, Islamic, and civic- Kazakhstani identity layers–carries the strongest positive correlation (ρ=+0.61; p<0.001). The normative architecture constructed between 2011 and 2024 is evaluated against these empirical predictors across four analytical levels: longitudinal trend analysis, regional identity profiling, factor correlation analysis, and institutional trust trajectories. The article finds that successive policy instruments have concentrated institutional resources on the weakest risk factor while leaving the strongest predictors structurally unaddressed. The post-2016 decline in registered criminal cases is attributed primarily to the organizational collapse of Islamic State of Iraq and the Levant as a recruitment structure rather than to domestic policy effectiveness. Trust in the state-affiliated religious authority declined by twenty percentage points over the period of maximum normative intensity–an outcome directly contrary to policy intent. The article concludes with three evidence-based corrective directions: reorienting the diagnostic framework toward monitoring identity fragmentation, recovering protective social factors as explicit policy targets, and restructuring formal religious authority to allow community-derived legitimacy to carry preventive functions.

Immune-Mediated Diarrhea And Colitis With Normal Biochemical, Endoscopic And Histologic Findings: A Retrospective Study, Malek Shatila, Sharada Wali, Carolina Colli Cruz, Kei Takigawa, Andres Caleb Urias Rivera, Kian Abdul-Baki, Tanvi Gupta, Elliot Baerman, Linfeng Lu, Irene Jeong-Ah Lee, Raakhi Menon, Hamza Salim, Andrew Sullivan, Varun Vemulapalli, Cristina Natha, Ayesha Khan, Krishnavathana Varatharajalu, Stephane Champiat, Kerry L Reynolds, Lucy B Kennedy, Katy Tsai, Anusha Shirwaiker Thomas, Yinghong Wang

Faculty, Staff and Students Publications

Background: Immune-mediated diarrhea and colitis (IMDC) due to checkpoint inhibition infrequently presents with normal stool biomarkers and no endoscopic or histologic evidence of inflammation. Little is known about the treatment needs and outcomes of this subset of patients. We aimed to describe this entity and clarify the role of immunosuppressive treatments in its management.

Method: This was a single-center, retrospective study of patients treated with immune checkpoint inhibitors who developed clinical symptoms of IMDC, with no evidence of inflammation based on fecal calprotectin or endoscopic/histologic evaluation, between January 2010 and February 2024.

Results: Of 1151 patients with IMDC, 131 (11.4%) …

Interdisciplinary Swiss Consensus Recommendations For Follow-Up After Radical Cystectomy And Trimodal Treatment For Muscle-Invasive Bladder Cancer, Ernest Kaufmann, Stefanie Aeppli, Andres Affentranger, Nicolas Arnold, Winfried Arnold, Fabian Aschwanden, Panagiotis Balermpas, Jörg Beyer, Uwe Bieri, Joost Boormanns, Richard Cathomas, Berardino De Bari, Marco Dressler, Daniel S Engeler, Andreas Erdmann, Andrea Gallina, Silvia Gomez, Matthias Guckenberger, Thomas Herrmann, Thomas Hermanns, Ilaria Lucca, Hubert John, Thomas Matthias Kessler, Jan Klein, Mohamed Laouiti, David Lauffer, Seth Paul Lerner, Agostino Mattei, Michael Müntener, Daniel Nguyen, Philipp Niederberger, Alexandros Papachristofilou, Lukas Prause, Paul Martin Putora, Karsten Reinhardt, Emanuela Salati, Philippe Sèbe, Mohamed Shelan, Silvan Sigg, Räto Thomas Strebel, Arnoud Jan Templeton, Ursula Vogl, Marian Severin Wettstein, Stephen Wyler, Deborah Zihler, Thomas Zilli, Daniel Zwahlen, Beat Roth, Christian Daniel Fankhauser

Faculty, Staff and Students Publications

Introduction: Radical cystectomy or trimodal therapy are treatment options for non-metastatic bladder cancer. However, there is limited evidence guiding post-treatment follow-up regimens, resulting in variations in care.

Objective: A Swiss consensus meeting aimed to identify gaps in follow-up strategies and subsequently tailoring follow-up protocols after curative treatment for bladder cancer.

Methods: A consensus meeting including participants from urology, oncology, radiation oncology, neuro-urology, international advisors, and patient representatives was held. 19 pre-formulated questions addressing follow-up duration, frequency, and modalities after radical cystectomy or trimodal therapy for bladder cancer were discussed and voted by participants.

Results: 42 experts from 22 institutions participated …

The All Of Us Evenings With Genetics Research Program, Stacy M Lloyd, Jasmine Baker, Carolina Jorgez, Julie Coleman, Laterrica Williams, April Adams, Ashley Butler, Elizabeth Atkinson, Shamika Ketkar, Steven Scherer, Kim Worley, Susan Fernbach, Keasia Daniels, Latanya Hammonds-Odie, Laura Rosales, Brendan Lee, Debra Murray

Faculty, Staff and Students Publications

The All of Us Evenings with Genetics (All of Us EwG) Research Program, funded in part by the National Institute of Health’s All of Us Research Program, engages researchers to utilize the All of Us Researcher Workbench to advance precision medicine. The All of Us EwG program has two core aims: (1) address barriers to research productivity for minorities, disadvantaged, and persons with disabilities aspiring to enter STEM fields; and (2) promote the use of the All of Us Researcher Workbench to develop research focused on health equity. To achieve these goals, the program implements three key activities: (1) …

Religion And International Relations: The Concept Of Soft Power And Orthodoxy In Kazakhstan, Ali Ukenov

Occasional Papers on Religion in Eastern Europe

This article examines the role of the Orthodox Church of Kazakhstan (OCK), a constituent part of the Russian Orthodox Church (ROC), within the framework of religious soft power. Following Russia’s invasion of Ukraine in 2022, the relationship between the ROC, Russian foreign policy, and transnational religious influence has attracted increased scholarly attention. Drawing on the concept of soft power and constructivist approaches, the study combines qualitative field research with media content analysis. The empirical material includes twenty semi-structured interviews conducted with Orthodox clergy and active parishioners across Kazakhstan, as well as an examination of the case of former priest Yakov …

Religious Transformation In The Post-Soviet Space: On The Example Of Kyrgyzstan, Atabek Galmamatov, Sagynbek Kozuev

Occasional Papers on Religion in Eastern Europe

This article examines the process of religious transformation in post-Soviet Kyrgyzstan, focusing particularly on its institutional, social, cultural, and political dimensions. The study aims to identify the main characteristics of religious transformation, analyze the factors that have shaped its development, and assess its implications for contemporary Kyrgyz society. Methodologically, the research combines historical, comparative, and qualitative approaches to examine changes from the Soviet period to the present. The analysis demonstrates that the collapse of Soviet atheistic ideology and the expansion of religious freedom created favorable conditions for the revival of religious institutions, the growth of mosques and madrassas 1 , …

Churches And Religious Communities In The Macedonian Constitution: Competing Visions Of Recognition And Equality, 1991-2001, Aleksandar Spasenovski

Occasional Papers on Religion in Eastern Europe

This article examines competing constitutional visions concerning churches and religious communities at two defining moments in the Macedonian constitutional order: the adoption of the 1991 Constitution and the amendments of 2001. Through a legal-historical analysis of constitutional provisions, proposed amendments, and parliamentary debates, it reconstructs four competing proposals from 1991: the designation of Orthodox Christianity as the official religion, special constitutional status for the Macedonian Orthodox Church, the joint recognition of the Macedonian Orthodox Church and the Islamic Religious Community, and a general separation-and-equality clause without naming particular religious organizations. The analysis relates these proposals to the political orientations of …

Mechanisms For Preventing Online Religious Discord: A Comparative Analysis Of Kazakhstani Experience And International Models For Regulating Religious Hate Speech, Kalmakhan Yerzhan, Lyazzat Kalybekova

Occasional Papers on Religion in Eastern Europe

The ever-increasing speed at which information spreads on the internet is giving rise to several serious challenges alongside its undeniable positive trends. This is especially clear in the increasing threat of online publications and comments that insult religious beliefs and incite discord, posing a risk of victimisation. Western researchers are conducting extensive studies on the definition and application of hate speech, its taxonomy, targeting, and prevention through artificial intelligence tools; studies grounded in the religious dimension are especially notable for highlighting the high relevance of these issues in today's complex geopolitical environment. Nevertheless, the majority of researchers argue that religion-based …

The Religious Field In Poland Under The Pressure Of Ukrainian Migration, Oleksandr Dobroier

Occasional Papers on Religion in Eastern Europe

An analysis of the transformation of the religious field in Poland between 2014 and 2024 in light of Ukrainian wartime migration. Using Pierre Bourdieu’s theory of the religious field as its conceptual framework, the study explores the redistribution of symbolic capital, the evolution of religious habitus, and the emergence of new actors within the field. Particular attention is given to the Roman Catholic Church, the Ukrainian Greek Catholic Church, the Orthodox Church of Ukraine, the Polish Autocephalous Orthodox Church, and evangelical communities. The study reveals a weakening of the RCC’s monopoly and an expansion of symbolic legitimacy among previously peripheral …

Reconciling Faith And Modernity: The Sociocultural Dynamics Of Jadidism As An Islamic Reformist Movement In The Russian Empire, Meltem Akıncı, Zhanerke Nyshanbay

Occasional Papers on Religion in Eastern Europe

This study examines the Jadidist movement as a fundamental sociocultural and religious- reformist phenomenon that redefined the intellectual, spiritual, and educational landscape of the Turkic-Muslim populations within the Russian Empire and Central Asia. Moving beyond traditional historical narratives, this article analyzes Jadidism through the lens of sociological theories of modernization, cultural identity, and transnational intellectual exchange, placing special emphasis on its Islamic reformist core. By integrating Western secular pedagogical models with indigenous Islamic renewal discourse, Jadidists attempted to navigate the delicate tension between religious tradition and modern demands. The research investigates the institutional development of "Usul-i Jadid" schools, the role …

Genome-Wide Association Study Identifies And Validates Genetic Variation In The Rig-I/Mavs Signaling Pathway Associated With Hiv-Related Kaposi Sarcoma In Children And Adults, Casey L Mcatee, Erin Peckham-Gregory, Pagna Sok, Melissa Richard, Luis Olivares, Deborah Marquez-Do, Grace Kisitu, Jeffrey Martin, Nader Kim El-Mallawany, Carl E Allen, Joseph Lubega, Michael E Scheurer

Faculty, Staff and Students Publications

Introduction: Immune deficiency and infection with human herpesvirus-8 (HHV-8) are established component causes of Kaposi sarcoma (KS), but they are insufficient to cause disease in most people at risk. Therefore, we hypothesized that genetic variation may contribute to KS risk in children and adults, as well as contribute to its unique epidemiology in sub-Saharan Africa.

Methods: To test this hypothesis, we conducted a two-phase genome-wide association study (GWAS): a discovery study in perinatally HIV-infected children (45 KS cases, 91 controls), followed by validation of significant results in a sample of adults living with HIV (215 cases, 262 controls). After standard …

Epigenetic Crosstalk In Neuroblastoma Development And Progression, Nathan Drolet, Amber Wolf, Joanna Yi, Eveline Barbieri

Faculty, Staff and Students Publications

Neuroblastoma (NB), a pediatric malignancy of the peripheral nervous system, accounts for 15% of pediatric cancer deaths and remains a major challenge for cancer therapy. NB originates from sympathoadrenal (SA) progenitors of the neural crest (NC) cell lineage, whose formation and differentiation are controlled by epigenetic mechanisms. Although signaling pathways and epigenetic factors implicated in NB tumorigenesis have been well-described, a holistic understanding of how development and epigenetics overlap to drive NB is lacking. By exploring vital interplays and co-dependencies between key pathways and their epigenetic control in NC development, we have gained novel insights into the mechanisms governing NB …

Case Report: Primed Dendritic Cell Immunotherapy For Multiple Solid Tumors, Jeffrey Jones, Aly Alrabaa, William Decker, Luis Ferbeyre, Gregorio Viramontes, Rafael Gonzalez, Elideth Angulo, Antonio Zamudio, Raul Hernandez, Stephen Noga, Susana Hernandez-Reyes, Paul Zhang, Darryl Smith, Ara Karamanian, Luis Tamara, Dalton Greenwood, Matthew Halpert

Faculty, Staff and Students Publications

Many patients with advanced solid tumors ultimately develop resistance to conventional therapies, with especially limited options for those experiencing rapid progression or poor performance status, highlighting the need for personalized immunotherapies capable of inducing durable responses. In this retrospective case series, we describe the clinical course and outcomes of five adults (4 male, 1 female; median age 51 years [range, 39-62]) with metastatic solid tumors who achieved complete and durable remission following doubly loaded autologous dendritic cell therapy after failure of standard treatments, such as immune checkpoint inhibition, radiation, surgery, or endocrine therapy. Five patients, including prostate adenocarcinoma (n=1), malignant …

Dynamic Progression Of Ectopic Lymphoid Structure Formation In Lacrimal Glands Of A Sjögren’S Disease Murine Model, Sara Abdelhamid, Alison V Ramirez, Emre Aksan, Elizaveta A Demianova, Cintia S De Paiva, Maria C Edman, J Andrew Mackay, Sarah F Hamm-Alvarez

Faculty, Staff and Students Publications

Background: Sjögren's Disease (SjD) is a chronic autoimmune condition characterized by lymphocytic infiltration of lacrimal glands (LG) and salivary glands (SG). In SG, these immune structures have properties of ectopic lymphoid structures (ELS) and appear to play a critical role in disease pathology. While the presence of ELS in patients' SG biopsies is linked to disease severity, their presence and composition in LG has not been well characterized.

Methods: The properties and time course of apparent ELS development in LG from the male non-obese diabetes free (NOR) sub-strain of the Non-Obese Diabetic (NOD) mice was investigated at stages encompassing early …

Utilizing A Culture System For Horizontal Cells To Study Neural Circuit Assembly In The Developing Mouse Retina, Ross M Perez, Yong H Park, Ajeet Singh, Collin Todora, Marlon F Mattos, Daniela Becerril, Rajashree Venkatraman, Arlene A Hirano, Nicholas C Brecha, Rinki Ratnapriya, Benjamin J Frankfort, Elizabeth Zuniga-Sanchez

Faculty, Staff and Students Publications

The precise wiring of the nervous system relies on neurons extending their processes at the right time and place to find their appropriate synaptic partner. The mechanisms that determine when and where neurons extend their neurites during synaptogenesis remains a central question in the field. In the present study, we used a cell culture system coupled with live imaging to investigate the wiring mechanisms in the developing mouse retina. We focused on horizontal cells which are a class of interneurons in the outer mouse retina known to synapse selectively to the distinct types of photoreceptors. Previous research has shown horizontal …

Non-Congenital Hsv-1 Keratitis In An Immunocompetent 9-Month-Old Infant, Caleb A Casanova, Stephanie Trejo Corona, Stephen F Pflugfelder

Faculty, Staff and Students Publications

Isolated, non-congenital herpes simplex virus type 1 (HSV-1) keratitis in immunocompetent infants is exceedingly rare and may be easily misdiagnosed, leading to delays in appropriate antiviral therapy. This case is unique in that it describes HSV-1 keratitis in a healthy 9-month-old infant presenting without systemic illness, initially treated as bacterial conjunctivitis. The patient presented with unilateral eye pain, redness, and corneal opacification. Subsequent evaluation revealed HSV-1 keratitis, and the patient was treated with intravenous acyclovir in combination with topical moxifloxacin and topical ganciclovir, resulting in complete resolution of symptoms within one week. This case adds to the limited literature on …

Updates In Mycobacterial Keratitis Diagnosis And Treatment, Uma L Balakrishnan, Ryan T Wallace, Patricia Chévez-Barrios, Alejandro Arboleda, Masih U Ahmed

Faculty, Staff and Students Publications

Mycobacterial keratitis is an uncommon but challenging form of infectious keratitis, often associated with postsurgical eyes. Clinical presentation is variable and may be difficult to recognize, resulting in delays in diagnosis and challenges in management. Traditional diagnostic techniques from corneal scrapings are limited by slow organism growth and may yield negative results. Treatment is challenging due to antimicrobial resistance and typically requires prolonged multidrug therapy. Advances in diagnostic modalities, antimicrobial therapies, surgical approaches, and adjunctive treatments such as corneal crosslinking have improved clinicians' ability to mitigate or avoid severe visual consequences. Despite these developments, optimal management strategies remain incompletely defined, …

Common And Recurrent Dysregulated Molecular Network Of Placental Hypoxia And Associated Vasculogenesis And Angiogenesis In Fetal Growth Restriction, Wei Li, Xiaoyi Bai, Oi Ka Chan, Maran Bo Wah Leung, So Ling Lau, Chi Chiu Wang, Tak Yeung Leung

Faculty, Staff and Students Publications

Fetuses with fetal growth restriction (FGR) and selective FGR (sFGR) face elevated health risks both before and after birth. Although the underlying pathomechanisms remain unclear, placental dysfunction is recognized as a major contributing factor. By integrating untargeted transcriptomic data from FGR/sFGR placentae, this study identified 69 differentially expressed mRNAs (DEmRs) and eight differentially expressed miRNAs (DEmiRs). Functional enrichment analysis demonstrated significant enrichment in the angiogenesis and vasculogenesis pathways, with the hypoxia-related genes

Combination Therapy With 308-Nm Excimer Laser, Compound Glycyrrhizin, And Tacrolimus For Pediatric Facial And Cervical Vitiligo, Yingying Qian, Yafen Wu, Wei Li, Qian Chen, Siyuan Song, Ting Zhang

Faculty, Staff and Students Publications

Background: Vitiligo is a common acquired depigmenting disorder in pediatric dermatology. Facial and cervical involvement is particularly distressing due to cosmetic disfigurement, leading to psychosocial impairment in children and significant psychological burden for parents. Safe and effective treatment strategies to halt disease progression and promote repigmentation are urgently needed.

Objective: To evaluate the clinical efficacy, onset of repigmentation, safety, and repigmentation patterns of 308-nm excimer laser combined with oral compound glycyrrhizin and topical 0.03% tacrolimus in children with facial and cervical vitiligo.

Methods: A total of 112 pediatric patients were randomized into two groups: treatment group (n=56, 86 lesions) received …

3d Geometric Modelling And Clinical Validation Of Lower Limb And Preliminary 2-Year Post-Operative Clinical Outcomes Of Neutral Boundary Alignment In Total Knee Arthroplasty, Bruno Violante, Lorenzo Deveza, Francesco Pollara, Giovanni Rusconi, Gianroberto Ferreri, Alessandro Annibaldi, Ilwhan Park

Faculty, Staff and Students Publications

Purpose: To introduce a novel three-dimensional (3D) modelling concept for lower limb alignment in total knee arthroplasty (TKA), termed neutral boundary alignment (NBA) and to present preliminary clinical data supporting this physics-based custom alignment strategy.

Methods: NBA is defined as the alignment at which the knee joint line is parallel to the ground during the mid-stance phase of gait, achieving static equilibrium with the NBA axis aligned to gravity. A theoretical geometric model of the lower limb was developed, integrating principles of physics to describe this condition. Preliminary clinical validation was performed using radiographic data from an initial cohort of …

Professionalism In Practice: A Novel Approach To Integrating Small Doses Of Case-Based Professionalism Education Into Monthly Grand Rounds., Allison H Taylor, Andrew Caruso, Kelley Arredondo, Ellen M Friedman, Stacey R Rose

Faculty, Staff and Students Publications

Introduction: Professionalism is a critical construct across the health professions, though learners and faculty report feeling underprepared to navigate difficult situations; education in professionalism is challenged by the absence of a universal definition, time constraints due to overcrowded curricula, and the lack of consistent messaging to learners and faculty.

Methods: Professionalism in Practice (PiP) was developed to provide small doses (∼5 minutes) of case-based professionalism education as part of an existing educational forum (Grand Rounds) to optimize attendance of both learners and faculty. Each vignette highlighted a common professionalism challenge and was aligned with an AAMC professional competency. Sessions were …

Functional Analysis Of Genes Enriched In Male Reproductive Organs: Validation Via Fertility Assessment Of 14 Knockout Mouse Lines, Kazumasa Takemoto, Katarzyna Kent, Kaori Nozawa, Shingo Tonai, Ahn H Pham, Terumi Fujimoto, Thomas X Garcia, Martin M Matzuk, Masahito Ikawa, Keizo Tokuhiro

Faculty, Staff and Students Publications

Tissue-restricted gene expression serves as a key indicator of functional importance within specific organs. Despite advances in high-throughput sequencing and genome editing over the past decade, this principle remains the gold standard for identifying candidate genes for functional studies. In reproductive biology, testis-restricted expression is anticipated to indicate genes crucial for gametogenesis, given the conserved features shared between spermatogenesis and oogenesis. Concurrently, rapid evolution of spermatogenesis-related genes is well documented and thought to arise through duplication and subsequent mutation of ubiquitously expressed genes. In this study, we established 14 knockout (KO) mouse lines for male reproductive organ-enriched genes, all of …