Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (276482)
- Law (201674)
- Arts and Humanities (178166)
- Medicine and Health Sciences (167291)
- Education (151072)
-
- Physical Sciences and Mathematics (117474)
- Life Sciences (108408)
- Engineering (78655)
- Business (72334)
- Communication (65537)
- History (55772)
- Sociology (43972)
- Higher Education (42399)
- Medical Specialties (42021)
- Journalism Studies (41530)
- Psychology (38262)
- Library and Information Science (37405)
- Religion (32160)
- Computer Sciences (31876)
- Public Affairs, Public Policy and Public Administration (28597)
- Public Health (26220)
- Mass Communication (26097)
- Medical Sciences (23664)
- United States History (22830)
- Nursing (21368)
- Economics (20338)
- Environmental Sciences (19861)
- Political Science (19087)
- Accounting (18878)
- Educational Administration and Supervision (18176)
- Institution
-
- University of Nebraska - Lincoln (44815)
- University of New Mexico (42081)
- University of Mississippi (38035)
- University of South Florida (35725)
- Brigham Young University (30308)
-
- San Jose State University (27402)
- University of Montana (25444)
- University of Kentucky (19667)
- Purdue University (19337)
- TÜBİTAK (18793)
- Utah State University (17479)
- Missouri University of Science and Technology (17270)
- University of Central Florida (16027)
- Singapore Management University (15933)
- Louisiana State University (15692)
- Western Kentucky University (15623)
- Walden University (15515)
- The Texas Medical Center Library (14710)
- California Polytechnic State University, San Luis Obispo (14032)
- Eastern Illinois University (13671)
- University of South Carolina (13595)
- Edith Cowan University (13594)
- City University of New York (CUNY) (13302)
- University of Northern Iowa (12955)
- Western Michigan University (12801)
- Nova Southeastern University (12781)
- Washington University School of Medicine (11813)
- University of Plymouth (11797)
- University of New Hampshire (11694)
- Georgia Southern University (11306)
- Keyword
-
- Newspaper (23851)
- Humans (15829)
- Education (12584)
- Spartan Daily (12403)
- Student newspaper (9917)
-
- History (8052)
- Female (7851)
- Newspapers (7264)
- EIU (7020)
- COVID-19 (6908)
- Male (6785)
- Higher education (6586)
- United States (6580)
- Western Kentucky University (6396)
- American newspapers (6368)
- Central Maine (6367)
- Journalism (6144)
- Newsletter (6076)
- Periodicals (5996)
- Bowling Green State University (5631)
- Faculty (5581)
- Communication (5205)
- Eastern Illinois University (5123)
- Daily Eastern News (5024)
- Poetry (4668)
- Student life (4638)
- Gender (4580)
- BG News (4446)
- Students (4431)
- Alumni (4342)
- Publication Year
-
- 2026 (51158)
- 2025 (71220)
- 2024 (79423)
- 2023 (73333)
- 2022 (73945)
-
- 2021 (75663)
- 2020 (74617)
- 2019 (69663)
- 2018 (65637)
- 2017 (62753)
- 2016 (60257)
- 2015 (54323)
- 2014 (51574)
- 2013 (48314)
- 2012 (47346)
- 2011 (39417)
- 2010 (37125)
- 2009 (32625)
- 2008 (29821)
- 2007 (27213)
- 2006 (25424)
- 2005 (22938)
- 2004 (21264)
- 2003 (19653)
- 2002 (18281)
- 2001 (16849)
- 2000 (16588)
- 1999 (14923)
- 1998 (14586)
- 1997 (13717)
- Publication
-
- Faculty Publications (25047)
- Theses and Dissertations (23502)
- Walden Dissertations and Doctoral Studies (13968)
- Faculty Scholarship (12182)
- Spartan Daily (School of Journalism and Mass Communications) (11411)
-
- Electronic Theses and Dissertations (10752)
- Articles (9640)
- Montana Kaimin, 1898-present (8723)
- Saudi Medical Journal (7869)
- Dissertations (7701)
- Library Philosophy and Practice (e-journal) (7495)
- Faculty, Staff and Student Publications (7289)
- Daily Mississippian (all digitized issues) (7123)
- Journal of Accountancy (6789)
- Honors Theses (6732)
- Masters Theses (6259)
- Open Access Publications (6228)
- WKU Administration Documents (6079)
- Theses (5965)
- Publications and Research (5889)
- Research Collection School Of Computing and Information Systems (5707)
- Journal of Extension (5420)
- Research outputs 2022 to 2026 (5183)
- Publications (5031)
- Graduate Theses and Dissertations (4956)
- Indiana Law Journal (4901)
- Albuquerque Morning Journal 1908-1921 (4754)
- BG News (Student Newspaper) (4497)
- Master's Theses (4427)
- Santa Fe New Mexican, 1883-1913 (4412)
- Publication Type
Articles 50941 - 50970 of 1733253
Full-Text Articles in Entire DC Network
Exploring Land, Language And Culture Through Playworld Translanguaging: One Child’S Meaning-Making Practices, Carly Steele, Toni Dobinson, Sender Dovchin, Christine Robinson, Grace Oakley, Wendy Cumming-Potvin, Graeme Gower, Katie Grace, Samina Manado
Exploring Land, Language And Culture Through Playworld Translanguaging: One Child’S Meaning-Making Practices, Carly Steele, Toni Dobinson, Sender Dovchin, Christine Robinson, Grace Oakley, Wendy Cumming-Potvin, Graeme Gower, Katie Grace, Samina Manado
Research outputs 2022 to 2026
Foregrounded in the work of Elizabeth Povinelli and drawing on semiotic theory, translanguaging and play-based learning pedagogies, this article presents findings from a critical participatory action research project conducted in an early years classroom in a remote Aboriginal community school in Western Australia. It describes how two educators, from both non-Aboriginal and Aboriginal backgrounds, collaborated to create spaces for the children in their classroom to engage deeply with their land, language and culture through intentional, purposeful and planned play, specifically Playworld Translanguaging. Findings are presented as a narrative account of one child’s meaning-making practices in collaboration with their teachers and …
Exploring The Dairy Milk Matrix Beyond Isolated Nutrients—A Narrative Review, Therese A. O’Sullivan, Analise Nicholl
Exploring The Dairy Milk Matrix Beyond Isolated Nutrients—A Narrative Review, Therese A. O’Sullivan, Analise Nicholl
Research outputs 2022 to 2026
The concept of the food matrix considers individual components along with how they are structured, interact, and are modified during processing. There is increasing interest around the health effects of individual nutrients versus whole foods, creating a need to better understand how the matrix may influence health outcomes. This narrative review explores the dairy milk matrix and compares health effects with those of isolated components, with additional comparisons to plant-based milk alternatives. Comparative evidence suggests that while calcium from food and supplements generally has similar effects (depending on the form of the supplemental calcium), consumption of food-based sources such as …
Global, Regional, And National Burden Of Epilepsy, 1990–2021: A Global Burden Of Disease Study, Jinqing Zhao, Qiannan Chen, Jiahan Dong, Meng Gao, Siqi Ge, Anxin Wang
Global, Regional, And National Burden Of Epilepsy, 1990–2021: A Global Burden Of Disease Study, Jinqing Zhao, Qiannan Chen, Jiahan Dong, Meng Gao, Siqi Ge, Anxin Wang
Research outputs 2022 to 2026
Background: Epilepsy is a common neurological disorder characterised by spontaneous seizures without an identifiable cause, leading to high morbidity and a significant public health burden. Understanding trends in its incidence, prevalence, mortality, and disability-adjusted life years (DALYs) is essential for developing effective prevention and treatment strategies. We aim to describe global trends in epilepsy over the past 32 years and explore the impact of sociodemographic index (SDI) levels on disease burden using the Global Burden of Disease 2021 data. Methods: We analysed the global burden of epilepsy (1990–2019) using age-standardised rates (ASRs) and their 95% uncertainty intervals (UI). We assessed …
Health Determinant Effects Of Audience Experiences At Live First Nations Music Events In Central Australia, Naomi Sunderland, Kristy Apps, Brigitta Scarfe, Ping Zhang, Darren Garvey, Rae Cooper, Brydie Leigh Bartleet, Phil Graham, Glenn Barry
Health Determinant Effects Of Audience Experiences At Live First Nations Music Events In Central Australia, Naomi Sunderland, Kristy Apps, Brigitta Scarfe, Ping Zhang, Darren Garvey, Rae Cooper, Brydie Leigh Bartleet, Phil Graham, Glenn Barry
Research outputs 2022 to 2026
Objectives: First Nations musicians often describe live performance as a means of fostering social, cultural, and political change that shapes determinants of health (DoH) for First Nations Peoples. This study examined how audience experiences of First Nations live music events in Central Australia may influence those DoH–including intercultural understanding, social cohesion, and community wellbeing–and explored the durability of such effects over time. Design: Guided by an Indigenist mixed‑methods approach, we conducted a pilot survey at two arts festivals featuring diverse First Nations musicians, followed by optional six‑month “mini yarn” interviews to explore immediate and longer‑term audience experiences. Quantitative analyses included …
It Was Part Of The Plan, So I Showed Up: An Exploration Of Patient Experiences With An Embedded Exercise Referral Process During Cancer Treatment, Mary A. Kennedy, Jack Dalla Via, Kim Edmunds, Pam Eldridge, Yvonne Zissiadis, Lauren Fortington
It Was Part Of The Plan, So I Showed Up: An Exploration Of Patient Experiences With An Embedded Exercise Referral Process During Cancer Treatment, Mary A. Kennedy, Jack Dalla Via, Kim Edmunds, Pam Eldridge, Yvonne Zissiadis, Lauren Fortington
Research outputs 2022 to 2026
Introduction: Exercise is a key part of cancer care, yet its integration into routine practice remains limited. This study explored the experiences of people living with and beyond cancer, with an updated, opt-out referral model embedded within a supportive oncology setting, focusing on initial engagement with exercise physiology appointments. Through this model, patients were automatically scheduled for a consultation with an in-house exercise professional during their cancer treatment. Methods: A qualitative descriptive design comprised of two focus groups with 13 participants was employed to explore views across pre-defined elements of the model: referral to exercise, appointments, counselling, and tailoring. Results: …
Opportunities To Improve The Implementation Of Relational Health Interventions For Children And Families: A Secondary Analysis Of A Scoping Review, Natasha Pearce, Natasha Pearce, Donna Cross, Jacinta Francis, Jonathan H. Sae-Koew, Alexander M. Godley, Caitlin Attwell, Tracy Evans-Whipp, Tracy Evans-Whipp, Jacqueline Allen, Ross Homel, Craig A. Olsson, Stephen R. Zubrick, Lu Zhang, Sarah Whittle, Liz Spry, Tim Slade, Lisa Ritland, Naomi Priest, Felicity Painter, Craig Olsson
Opportunities To Improve The Implementation Of Relational Health Interventions For Children And Families: A Secondary Analysis Of A Scoping Review, Natasha Pearce, Natasha Pearce, Donna Cross, Jacinta Francis, Jonathan H. Sae-Koew, Alexander M. Godley, Caitlin Attwell, Tracy Evans-Whipp, Tracy Evans-Whipp, Jacqueline Allen, Ross Homel, Craig A. Olsson, Stephen R. Zubrick, Lu Zhang, Sarah Whittle, Liz Spry, Tim Slade, Lisa Ritland, Naomi Priest, Felicity Painter, Craig Olsson
Research outputs 2022 to 2026
Despite the availability of universally delivered evidence-based relational health interventions, their wide-scale translation into practice is slow and unsustained. Measuring implementation outcomes within intervention trials is critical to understand their effectiveness and inform future scaling. This study aimed to determine the extent to which universally delivered relational health interventions measured and reported on implementation outcomes to inform their effectiveness. A secondary analysis of a scoping review examined the extent to which 123 RCT-evaluated relational health intervention studies referred to (1) implementation related theories or frameworks; (2) implementation data collection methods; (3) implementation measures, and; (4) each of twelve implementation outcomes …
Peptidomic Profiling Of In Vitro Digesta From Diverse Microalgae Species, Sara Hamzelou, Damien Belobrajdic, Henri Brook, Wei Chen, Fletcher Hiten, Kim Lee Chang, Diane Purcell, Utpal Bose, Simone Osborne, Cassandra Pegg, Michelle L. Colgrave
Peptidomic Profiling Of In Vitro Digesta From Diverse Microalgae Species, Sara Hamzelou, Damien Belobrajdic, Henri Brook, Wei Chen, Fletcher Hiten, Kim Lee Chang, Diane Purcell, Utpal Bose, Simone Osborne, Cassandra Pegg, Michelle L. Colgrave
Research outputs 2022 to 2026
Microalgae are a sustainable protein source, yet few species are used for human nutrition. This study evaluated eight species for protein quality, digestibility, and peptide profiles after simulated gastrointestinal digestion using INFOGEST. Amino acid content, and intestinal-phase peptide mixtures were analysed by mass spectrometry. The methanol precipitation method was used to separate digested (supernatant) and undigested (pellet) peptides following in vitro INFOGEST digestion. The pellet was further separated by molecular weight into 3–10 kDa and >10 kDa fractions to isolate the lower molecular weight peptides from the higher ones. This separation method enabled the identification of potential digested peptides within …
Putting Lived Experience At The Centre: A Critical Review Of Multidisciplinary, Person-Centred Mental Health Care, Laura Grattidge, Darren Haywood, Nicolas H. Hart, Bridget Elizabeth Hamilton, Ellie Fossey, Melissa Petrakis, David J. Castle
Putting Lived Experience At The Centre: A Critical Review Of Multidisciplinary, Person-Centred Mental Health Care, Laura Grattidge, Darren Haywood, Nicolas H. Hart, Bridget Elizabeth Hamilton, Ellie Fossey, Melissa Petrakis, David J. Castle
Research outputs 2022 to 2026
Purpose: Person-centred care is widely endorsed in mental health policy yet remains inconsistently enacted in multidisciplinary practice, particularly where services default to diagnostic dominance, risk management, and service-led priorities. This critical review examines what is required to operationalise person-centred, rights-based care across disciplines and settings, positioning lived and living experience as core expertise rather than a supplementary perspective and considering implications for suicide prevention. Methods: A critical review of peer-reviewed and grey literature was undertaken, focusing on person-centred and multidisciplinary mental health care. Five commonly used approaches were compared: the Optimal Health Program, the Strengths Model, Open Dialogue, traditional case …
Reflecting On Themes From Telehealth Consultations Early In The Pandemic: An Opportunity To Learn From Multiprofessional Colleagues, Maggie Meeks, Laura R. Joyce, John Dean, Lorna Davies, Tika Ormond, Philippa Seaton, Dale Sheehan, Dean Sutherland, Melanie Welfare, Arindam Basu
Reflecting On Themes From Telehealth Consultations Early In The Pandemic: An Opportunity To Learn From Multiprofessional Colleagues, Maggie Meeks, Laura R. Joyce, John Dean, Lorna Davies, Tika Ormond, Philippa Seaton, Dale Sheehan, Dean Sutherland, Melanie Welfare, Arindam Basu
Research outputs 2022 to 2026
Aims: This study is aimed at documenting the reflections of New Zealand healthcare professionals on the use of synchronous telehealth consultations. Methods: A qualitative narrative inquiry was conducted to explore the practice of telehealth in New Zealand. Purposive sampling was used to identify clinicians from multiple professions who used telehealth during the initial phase of the COVID-19 pandemic. Fifteen semistructured interviews were conducted between October 2020 and May 2021 with clinicians from primary and secondary care, including multiple professional backgrounds. Interview transcripts were analysed thematically. Results: Six themes were identified: (1) equitable access: There were concerns regarding equitable access to …
Scope And Adherence To The Consider Statement In Aboriginal And Torres Strait Islander Injury Prevention Research In Australia, Bep Uink, Michelle Barrett, Courtney Ryder, Aleina Humphreys, Graham Peter Barker
Scope And Adherence To The Consider Statement In Aboriginal And Torres Strait Islander Injury Prevention Research In Australia, Bep Uink, Michelle Barrett, Courtney Ryder, Aleina Humphreys, Graham Peter Barker
Research outputs 2022 to 2026
Introduction: Effective injury prevention for Aboriginal and Torres Strait Islander people hinges on the availability of culturally safe policies, resources and programmes, alongside best-practice research. Contemporary injury prevention research has increasingly centred Aboriginal and Torres Strait Islander knowledges, yet there is still room for improvement. Identification of relevant resources, policies and programmes, as well as the extent to which injury prevention research meets international criteria for ethical research with Aboriginal and Torres Strait Islander peoples will provide practitioners with critical insights into best-practice injury prevention initiatives. Method: We examined the breadth and scope of Aboriginal and Torres Strait Islander injury-related …
Strengthening Social Structures To Improve Informal Care For Older People With Chronic Life-Limiting Illnesses In Rural Ghana, Barbara Adonteng-Kissi, Obed Adonteng-Kissi
Strengthening Social Structures To Improve Informal Care For Older People With Chronic Life-Limiting Illnesses In Rural Ghana, Barbara Adonteng-Kissi, Obed Adonteng-Kissi
Research outputs 2022 to 2026
Traditional family-based care for older people in Ghana is declining as globalization and social change weaken historical support systems. This analysis is informed by a review of scholarly literature concerning the implications of globalization for the provision of caregiving for older people managing chronic life-limiting illnesses. We aimed to explore ways of strengthening social structures to enhancing the quality of lives of older people with chronic life-limiting illnesses in rural Ghana amongst 15 older people; 15 family caregivers; 10 healthcare professionals. Critical Social Theory (CST) functions as the primary theoretical framework for conducting an interrogation of the systemic structures that …
The First Systematic Review Of Treatment Characteristics And Recidivism Outcomes For Indigenous People Who Have Sexually Offended, James L. Finney, Natalie Gately, Suzanne Rock, Braden Hill
The First Systematic Review Of Treatment Characteristics And Recidivism Outcomes For Indigenous People Who Have Sexually Offended, James L. Finney, Natalie Gately, Suzanne Rock, Braden Hill
Research outputs 2022 to 2026
It is of great importance that research investigates the impact of sexual offender treatment programmes given the damage caused by sexual offences to victims and society more broadly. However, psycho-criminological literature has focused on reporting post-treatment recidivism outcomes for people who have sexually offended homogeneously and has not investigated the unique experiences of Indigenous people. Therefore, we systematically collated and critically appraised studies reporting recidivism outcomes for Indigenous people who have received treatment for sexual offences. Fourteen studies were identified utilising a sample of 5,635 individuals (30.7% Indigenous or First Nations). Recidivism was lower for Indigenous and First Nations people …
Towards Transgressive Inclusion In Physical Education? The Experiences And Perspectives Of People With Disabilities In Western Australia, Steven Connelly, Dawn Penney, David Aldous
Towards Transgressive Inclusion In Physical Education? The Experiences And Perspectives Of People With Disabilities In Western Australia, Steven Connelly, Dawn Penney, David Aldous
Research outputs 2022 to 2026
This paper foregrounds the voices of people with disabilities (PwD) and their experiences of Physical Education (PE) in Western Australia (WA) in exploring interests in transgressive inclusion that are grounded in social justice and equity for PwD (DeLuca, 2013). Towards an interdisciplinary framework for educational inclusivity. Canadian Journal of Education, 36(1), 305–348. https://journals.sfu.ca/cje/index.php/cje-rce/article/view/1157/1475). The study employed a questionnaire method to pursue the perspectives of PwD in relation to (i) their experiences of lower secondary PE (years 7-10), (ii) teacher support in PE classes, (iii) experiences beyond PE in sport and physical activity, and (iv) their views regarding ways to improve …
A Knowledge-Driven, Ai-Assisted Cyber Defence Framework For Iomt Remote Patient Monitoring, Kulsoom S. Bughio, David M. Cook, Abdul M. Unar
A Knowledge-Driven, Ai-Assisted Cyber Defence Framework For Iomt Remote Patient Monitoring, Kulsoom S. Bughio, David M. Cook, Abdul M. Unar
Research outputs 2022 to 2026
The rapid adoption of Internet Medical Things (IoMT) technologies in remote patient monitoring has reshaped healthcare delivery by enabling continuous, real-time clinical observation outside traditional care settings. However, this shift has also expanded the cyber-attack surface across heterogeneous, resource-constrained medical devices, wireless networks, cloud services, and third-party platforms. In cyber warfare, healthcare has become an incorporated target of geopolitics, with hospitals, remote monitoring systems, and emergency health systems being used to broaden the attack surface for adversaries to exploit. Existing security approaches for IoMT environments remain largely manual, fragmented, and reactive, limiting their effectiveness in dynamically assessing vulnerabilities and supporting …
A Survey-Based Assessment Of Treatment Preferences For Distal Radius Fractures In Participants Aged 65 Years And Older, Zayd Al Rawi, Elizabeth Graesser, Lindley B Wall
A Survey-Based Assessment Of Treatment Preferences For Distal Radius Fractures In Participants Aged 65 Years And Older, Zayd Al Rawi, Elizabeth Graesser, Lindley B Wall
2020-Current year OA Pubs
PURPOSE: The management of distal radius fractures (DRF) in patients aged ≥65 years is debated because there is evidence that operative and nonsurgical treatment yield similar outcomes 1 year after injury. When more than one reasonable treatment option exists, shared decision-making between the patient and physician should be used. This study elicited preferences for the treatment of DRF using a survey of participants aged ≥65 years.
METHODS: A survey for participants ≥65 years was administered using Amazon Mechanical Turk. Participants were presented with a theoretical scenario in which they sustained a DRF, followed by two treatment options (surgery or casting) …
Phase I Trial Of Adp-A2afp Tcr T-Cell Therapy In Patients With Advanced Hepatocellular Or Gastric Hepatoid Carcinoma, Tim Meyer, Benjamin R Tan, Et Al.
Phase I Trial Of Adp-A2afp Tcr T-Cell Therapy In Patients With Advanced Hepatocellular Or Gastric Hepatoid Carcinoma, Tim Meyer, Benjamin R Tan, Et Al.
2020-Current year OA Pubs
BACKGROUND & AIMS: Patients with advanced hepatocellular carcinoma (HCC) generally experience poor outcomes despite current therapies, necessitating the development of alternative treatments. ADP-A2AFP is an investigational autologous T-cell therapy with an affinity-enhanced T-cell receptor (TCR) targeting alpha-fetoprotein (AFP).
METHODS: We describe a phase I, open-label, first-in-human clinical trial of ADP-A2AFP (NCT03132792) in human leukocyte antigen-eligible participants with AFP-expressing HCC (or other tumor) not amenable to transplant/resection who progressed on, were intolerant to, or refused prior systemic therapy. Participants received lymphodepletion chemotherapy (cyclophosphamide 500 mg/m
RESULTS: Twenty-one participants, 20 with advanced HCC and one with gastric hepatoid carcinoma received ≥1 ADP-A2AFP …
Cutibacterium Adaptation To Life On Humans Provides A Potential C Acnes Infection Biomarker, Md Shafiuddin, Wen-Chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney Brianna Sillart, Jonathan Z Tang, Michael R Vittori, Michael J Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P Henderson, Alexander W Aleem, Ma Xenia Garcia Ilagan, William H Mccoy 4th
Cutibacterium Adaptation To Life On Humans Provides A Potential C Acnes Infection Biomarker, Md Shafiuddin, Wen-Chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney Brianna Sillart, Jonathan Z Tang, Michael R Vittori, Michael J Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P Henderson, Alexander W Aleem, Ma Xenia Garcia Ilagan, William H Mccoy 4th
2020-Current year OA Pubs
Propionibacteriaceae appear to have adapted to life on humans during the domestication of cattle. These microbial immigrants formed the genus Cutibacterium, and a descendent of those microbial trailblazers (C acnes) now dominates 25% of human skin. C acnes colonization of human skin requires the protein RoxP. Although all Cutibacteria encode this adaptation to life on humans, nothing like RoxP has been found in any other organism. In this study, we report an extensive assessment of 21 RoxP orthologs, which identified conserved molecular surfaces linked to heme-dependent oligomerization and low pH stability. Our investigation suggests how RoxP helps C acnes dominate …
Coordinated Regulation Of Capping Protein By Carmil And V-1/Myotrophin, John A Hammer, John A Cooper
Coordinated Regulation Of Capping Protein By Carmil And V-1/Myotrophin, John A Hammer, John A Cooper
2020-Current year OA Pubs
Capping Protein (CP) plays a central role in controlling actin filament dynamics in almost all eukaryotic cell types by virtue of its ability to block monomer addition and loss at the barbed end of the actin filament. Like other proteins that control actin assembly, CP is subject to regulation. Here we focus on two direct regulators of CP-CARMIL and V-1/Myotrophin. Specifically, we review recent biochemical, structural, imaging, and cell biological data that argue these two proteins cooperate to create a regulatory cycle for CP that controls its availability, activity, and site of action in the cell. Finally, we discuss unresolved …
Mutations In Hsp40 Co-Chaperone Change The Canonical Interdomain Interactions Stimulating Lgmdd1 Myopathy, Ankan K Bhadra, Geetika Aggarwal, Anshuman Jaysingh, Daniel Chen, Jil Daw, Conrad C Weihl, Heather L True
Mutations In Hsp40 Co-Chaperone Change The Canonical Interdomain Interactions Stimulating Lgmdd1 Myopathy, Ankan K Bhadra, Geetika Aggarwal, Anshuman Jaysingh, Daniel Chen, Jil Daw, Conrad C Weihl, Heather L True
2020-Current year OA Pubs
Limb-girdle muscular dystrophy D1 (LGMDD1) is a rare, dominantly inherited neuromuscular protein-misfolding chaperonopathy caused by mutations in the Hsp40 co-chaperone DNAJB6, primarily in the glycine-phenylalanine (GF) or J-domains. Currently, no treatments are available, and a challenge in understanding the disease is identifying a specific client protein for DNAJB6 in skeletal muscle. DNAJB6 has homology to the yeast DNAJ family member, Sis1. Our previous research indicated that LGMDD1 GF domain mutants in Sis1 exhibit substrate-specific effects, influenced by Hsp70 activity. Herein, we employed functional assays along with advanced molecular simulation studies to understand the regulatory interdomain interactions in disease-causing mutants of …
Oculomics And Ai: The Eye As A Biomarker For Health Span, Joy Le Yi Wong, Rajendra S Apte, Et Al.
Oculomics And Ai: The Eye As A Biomarker For Health Span, Joy Le Yi Wong, Rajendra S Apte, Et Al.
2020-Current year OA Pubs
As the world's population ages, the focus of healthcare is shifting from extending life span to promoting health span. There is an unmet need to identify sensitive and reliable markers of health span through more cost-effective and non-invasive methods, to enable early and effective intervention on modifiable aging factors. The eye offers a unique window into systemic health, providing direct visualization of the body's vascular and neural health. This review presents an overview of how various ocular structures can serve as biomarkers of health span-drawing on insights from ocular imaging, metabolomics, and proteomics, with evidence from basic science, animal models, …
Airway Management In Emergency Department Thoracotomy: A Narrative Review, Aaron J Lacy, Adam Liebendorfer, Sarah M Guess, Rami S Al-Aref, Anthony P Kronfli, Rachel E Armstrong, Amelia W Maiga, Alexander Bracey, Ryan N Barnicle
Airway Management In Emergency Department Thoracotomy: A Narrative Review, Aaron J Lacy, Adam Liebendorfer, Sarah M Guess, Rami S Al-Aref, Anthony P Kronfli, Rachel E Armstrong, Amelia W Maiga, Alexander Bracey, Ryan N Barnicle
2020-Current year OA Pubs
INTRODUCTION: Emergency department thoracotomy (EDT) is a high-risk, life-saving intervention for patients in traumatic cardiac arrest. A critical component of EDT is airway management, typically performed by emergency physicians, yet formal guidance regarding optimal strategies remains limited. Airway management in this setting is uniquely complex due to concurrent anatomic injury, physiologic instability, and the procedural demands of thoracotomy.
DISCUSSION: Endotracheal intubation (ETI) during EDT presents multiple challenges. Anatomic difficulties may arise from facial or cervical trauma, restricted positioning, and the presence of cervical collars. Cognitive load is heightened by the chaotic, multidisciplinary environment, requiring strategies such as pre-briefing, checklists, and …
Foot-Specific Exercise Intervention For Forefoot Deformity In Individuals With Type 2 Diabetes And Peripheral Neuropathy: A Randomized Controlled Clinical Trial With 3-Year Follow-Up, J A Zellers, K Steger-May, P K Commean, H-J Jeong, E M Bullard, M J Mueller, M K Hastings
Foot-Specific Exercise Intervention For Forefoot Deformity In Individuals With Type 2 Diabetes And Peripheral Neuropathy: A Randomized Controlled Clinical Trial With 3-Year Follow-Up, J A Zellers, K Steger-May, P K Commean, H-J Jeong, E M Bullard, M J Mueller, M K Hastings
2020-Current year OA Pubs
BACKGROUND: Diabetes with peripheral neuropathy can lead to metatarsophalangeal joint (MTPJ) deformity. The purpose of this study was to estimate the effect of a foot-specific intervention on MTPJ deformity. Secondary aims were determining MTPJ deformity progression over 3 years and predictors of MTPJ deformity progression.
METHODS: Sixty people with type 2 diabetes and peripheral neuropathy were recruited for this randomized controlled clinical trial. Participants were assessed at baseline, 6 months (post-intervention), 1.5 years, and 3 years. A 6-month, foot-specific intervention in the experimental group was compared to a shoulder intervention in the control group. The primary outcome was change in …
Perceived Hiv Risk, Barriers, And Preferences For Hiv Testing In Structurally Vulnerable Communities In St. Louis: A Best-Worst Scaling Survey, Emmanuel K Tetteh, Noelle Le Tourneau, Gregory Gross, Mckenzie Swan, Tyrell Manning, Justin Cole, Katie Wolf, Lawrence Hudson-Lewis, Julia D López, Todd Combs, Virginia R Mckay
Perceived Hiv Risk, Barriers, And Preferences For Hiv Testing In Structurally Vulnerable Communities In St. Louis: A Best-Worst Scaling Survey, Emmanuel K Tetteh, Noelle Le Tourneau, Gregory Gross, Mckenzie Swan, Tyrell Manning, Justin Cole, Katie Wolf, Lawrence Hudson-Lewis, Julia D López, Todd Combs, Virginia R Mckay
2020-Current year OA Pubs
BackgroundPersistent gaps in efforts to end the HIV epidemic in the United States highlight the need for community-specific, evidence-based HIV testing strategies. This study investigated barriers and preferences around HIV testing among underserved populations, including Black, queer, and young adults in the St. Louis, Missouri area.MethodsWe conducted a Best-Worst Scaling (BWS) survey with adults (16+ years) recruited at community events, collecting responses electronically and providing a $25 incentive. The survey assessed the relative importance of 13 potential barriers to HIV testing such as stigma, structural barriers, and perceived HIV risk, chosen based on literature review and community input. Mean preference …
Indigenous Stewardship And Co-Management In Action: A Case Study On Blue Carbon From A Mangrove Ecosystem On The Great Barrier Reef, Micheli D.P. Costa, I. Noyan Yilmaz, Pawel Waryszak, Rory Crofts, Melissa Wartman, Pere Masqué, Brian Singleton, Gavin Singleton, Ashlyn Skeene, Lucy Friend, Peter I. Macreadie
Indigenous Stewardship And Co-Management In Action: A Case Study On Blue Carbon From A Mangrove Ecosystem On The Great Barrier Reef, Micheli D.P. Costa, I. Noyan Yilmaz, Pawel Waryszak, Rory Crofts, Melissa Wartman, Pere Masqué, Brian Singleton, Gavin Singleton, Ashlyn Skeene, Lucy Friend, Peter I. Macreadie
Research outputs 2022 to 2026
Blue carbon ecosystems play a vital role in climate change mitigation and adaptation through their capacity to sequester and store organic carbon. Queensland, Australia, contains over 500,000 ha of mangroves, much of it under the stewardship of Traditional Custodians. The mangrove forests of the Bidakarra (Barron River) estuary provide a unique opportunity to demonstrate how Indigenous leadership, scientific research, and local industry partnerships can advance both ecological and cultural outcomes. We present a co-designed case study from Kukujum (Ellie Point), an area co-managed by Cairns Airport, Yirrganydji Gurabana Aboriginal Corporation, and the Yirrganydji Land and Sea Ranger Program through Dawul …
Implementation Strategies For Evidence-Based Healthcare Interventions In Rural And Remote Settings: A Scoping Review, Anna Chapman, Cadeyrn J. Gaskin, Hannah Beks, Charlene Wright, Skye Marshall, Elizabeth A. Johnston, Rebecca J. Bergin, Sharina Riva, Fiona Crawford-Williams, Camille E. Short, Nicole Kiss, Sze Lin Yoong, Nicolas H. Hart, Anna Wong Shee, Helena Rodi, Hannah Jongebloed, Anna Ugalde
Implementation Strategies For Evidence-Based Healthcare Interventions In Rural And Remote Settings: A Scoping Review, Anna Chapman, Cadeyrn J. Gaskin, Hannah Beks, Charlene Wright, Skye Marshall, Elizabeth A. Johnston, Rebecca J. Bergin, Sharina Riva, Fiona Crawford-Williams, Camille E. Short, Nicole Kiss, Sze Lin Yoong, Nicolas H. Hart, Anna Wong Shee, Helena Rodi, Hannah Jongebloed, Anna Ugalde
Research outputs 2022 to 2026
Globally, people living in rural and remote areas experience poorer healthcare access and outcomes than urban populations. Applying implementation strategies that support the translation of evidence-based healthcare interventions may help reduce these inequities; however, real-world implementation is complex, and it remains unclear how strategies are applied and tailored to rural and remote contexts. This scoping review synthesised evidence on implementation strategies for healthcare interventions in rural and remote settings of high-income countries. Five databases (Ovid MEDLINE, Embase, Cochrane CENTRAL, CINAHL, Web of Science) were searched for peer-reviewed studies published between 1/1/2000 and 25/10/2024. Extracted data were synthesised using a descriptive …
Managing Hybrid Workers And Teams In The Public Sector: From Management By Results To Purposeful Management, Judy Lundy, Uma Jogulu, Helen Taylor, Sue Williamson
Managing Hybrid Workers And Teams In The Public Sector: From Management By Results To Purposeful Management, Judy Lundy, Uma Jogulu, Helen Taylor, Sue Williamson
Research outputs 2022 to 2026
Purpose – Hybrid working has become “business as usual” in Australian public service (APS) organisations, however, limited guidance exists for managers in this sector. This paper aims to identify the management capabilities currently being used and those required for effective management of public sector hybrid workers. Design/methodology/approach – The research is based on the APS as a case study. The research team collected data from 20 focus groups and interviews with 83 managers and supervisors in the APS to answer: What capabilities are public sector managers using to manage hybrid working teams? What additional capabilities are needed? Findings – Participants …
Metaverse And Artificial Intelligence As Web 4.0: The Next Generation Of The Internet, Anton Klarin, Elena Gorenskaia, Qijie Xiao, Pi-Shen Seet
Metaverse And Artificial Intelligence As Web 4.0: The Next Generation Of The Internet, Anton Klarin, Elena Gorenskaia, Qijie Xiao, Pi-Shen Seet
Research outputs 2022 to 2026
This study utilizes systems thinking to explore and entwine an evolving metaverse scholarship to a relatively underexplored phenomenon of Web 4.0. We adopt a soft systems thinking framework to guide the interpretation of complex and evolving metaverse scholarship, using bibliometric mapping of 5587 publications sourced from Scopus. Using systems thinking, we synthesize these clusters into the following four thematic areas: (i) business and society implications, (ii) optimization, (iii) integration with other technologies and (iv) metaverse education. Drawing on the largest-to-date review of the metaverse as well as a systematic review of Web 4.0 literature, we propose a novel conceptualization of …
Nursing Leadership And Pandemic Preparedness Via Game-Based Learning Simulation: A Narrative Review (Registered Nurses And Undergraduate Nursing Students), Scott James Andrews, Olivia Gallagher, Alecka Miles, Carol Crevacore, Brennen Mills
Nursing Leadership And Pandemic Preparedness Via Game-Based Learning Simulation: A Narrative Review (Registered Nurses And Undergraduate Nursing Students), Scott James Andrews, Olivia Gallagher, Alecka Miles, Carol Crevacore, Brennen Mills
Research outputs 2022 to 2026
Background: Early progression of newly registered nurses into leadership roles is commonplace in clinical settings. Nurses and student nurses can prepare for leadership by gaining exposure through simulation-based learning. A novel and expanding modality are game-based learning (GBL) simulation. Nurse leaders play a crucial role during pandemics, guiding their teams through crises and ensuring effective response strategies. Reviewing the literature to identify the content, structure, and effectiveness of current pandemic preparedness and GBL simulation in nursing education is necessary to identify lessons learnt during the COVID-19 pandemic response to guide workforce preparation for future surge planning. Aim: The aim of …
Satellite Observations Reveal Ecosystem Resistance And Resilience To Short-Term Water Stress Driven By Dominant Vegetation Along A Rainfall Gradient In Australia, Huanhuan Wang, Qiaoyun Xie, Sally E. Thompson, Caitlin E. Moore, David L. Miller, Erik J. Veneklaas, Richard P. Silberstein, Xing Li, Jingfeng Xiao, Belinda E. Medlyn, William K. Smith
Satellite Observations Reveal Ecosystem Resistance And Resilience To Short-Term Water Stress Driven By Dominant Vegetation Along A Rainfall Gradient In Australia, Huanhuan Wang, Qiaoyun Xie, Sally E. Thompson, Caitlin E. Moore, David L. Miller, Erik J. Veneklaas, Richard P. Silberstein, Xing Li, Jingfeng Xiao, Belinda E. Medlyn, William K. Smith
Research outputs 2022 to 2026
Climate change is projected to intensify water stress in many ecosystems and poses threats to their stability, which can be quantified through ecosystem resistance and resilience. Relevant studies mostly focused on multi-year or annual droughts, and in spatially homogeneous or species-specific ecosystems. However, resilience and resistance within complex ecosystems, where different plants exhibit different adaptations and recovery behaviours, are less understood. Using productivity data from satellite-derived GOSIF (Global Orbiting Carbon Observatory-2 Solar-Induced Fluorescence) and flux towers, we examined vegetation responses to short-term (<1 year) water stress events from 2000 to 2018 along the North Australia Tropical Transect, which spans a 1600 mm rainfall gradient and transitions from seasonal mesic to non-seasonal arid ecosystems. We define resistance as productivity maintained during stress relative to a multi-year average baseline, and resilience as the extent to which productivity recovered one year after stress relative to the same baseline. Our results show that ecosystem resistance to water stress was lowest in semi-arid regions but higher in both arid and mesic regions, while ecosystem resilience showed the opposite pattern. These spatial patterns occurred regardless of seasonality and were mainly associated with dominant vegetation type. Woody savanna-dominated mesic regions exhibited highest resistance (0.82 ± 0.13, p < 0.001) and lowest resilience (0.26 ± 0.19, p < 0.001), shrublands in arid areas had intermediate values of both resistance (0.81 ± 0.14, p < 0.001) and resilience (0.27 ± 0.22, p < 0.001), while the grasslands in semi-arid regions had low resistance (0.78 ± 0.15, p < 0.001) and high resilience (0.38 ± 0.24, p < 0.001). The highest likelihood (>75.0 %) of full recovery (i.e., exceeding baseline after one year) occurred during the wet season in …1>
Single Joint Posterior Chain Isometric Testing Using Force Plates: A Systematic Review Of The Methodologies And Reliability Of Testing Methods, Jack T. Fahey, Christopher Bramah, Richie Barber, James Williams, John J. Mcmahon, Paul Comfort, Nicholas J. Ripley
Single Joint Posterior Chain Isometric Testing Using Force Plates: A Systematic Review Of The Methodologies And Reliability Of Testing Methods, Jack T. Fahey, Christopher Bramah, Richie Barber, James Williams, John J. Mcmahon, Paul Comfort, Nicholas J. Ripley
Research outputs 2022 to 2026
The posterior chain muscles (i.e. hamstring and gluteal) play an important role in performance and injury prevention. Posterior chain muscle injuries lead to time lost from training, competition and increased reinjury risk. Force plates enable valid and reliable assessment, current methods assessing isometric posterior chain (IPC) force production using force plates have yet to be reviewed. This review was designed to systematically review methods of single joint IPC force plate testing; establish existing reliability; and summarise descriptive data. A literature search was conducted using the following search terms: ‘force plat*’ AND ‘isometric’ AND (‘hamstring*’ OR ‘knee flex*’ OR ‘posterior chain’ …