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Articles 50881 - 50910 of 1732504
Full-Text Articles in Entire DC Network
Regulation Of Private Higher Education In Mexico: How Non-Elite Institutions Navigate Authorization, Edson Eduardo Navarro Meza
Regulation Of Private Higher Education In Mexico: How Non-Elite Institutions Navigate Authorization, Edson Eduardo Navarro Meza
Electronic Theses & Dissertations (2024 - present)
Low quality, excessive commercialization, fraud, profit in disguise, and predatory dynamics remain the most pressing regulatory challenges in the context of private higher education in Mexico. These problems have been largely attributed to the ineffectiveness of authorization mechanisms, which have repeatedly become the focus of controversy and criticism from social, academic, and media sectors regarding their role in shaping the development of the sector. Some observers blame the government for its inaction in the face of rapid institutional proliferation, as well as for maintaining authorization procedures that have proven to be ineffective gatekeepers of sectoral expansion. Others place responsibility on …
Hepatitis C Among Persons Who Inject Drugs In New York State: Progress Towards Elimination, Meredith A. Barranco
Hepatitis C Among Persons Who Inject Drugs In New York State: Progress Towards Elimination, Meredith A. Barranco
Electronic Theses & Dissertations (2024 - present)
Background: Hepatitis C virus (HCV) infection is one of the leading causes of liver disease in the United States (US) and worldwide. In the United States today, HCV is transmitted primarily through injection drug use (IDU) and therefore disproportionately impacts persons who inject drugs (PWID), a population with a range of complex social and health needs. HCV is not vaccine-preventable but can be cured in over 90% of cases with an 8–12-week course of daily direct-acting antiviral (DAA) medication. Since approval of curative medications in 2014, various jurisdictions have developed plans to eliminate HCV. In 2021, the New York State …
The Effects Of Vitamin K On Neuronal Ferroptosis, Chelsey P. Eighmey
The Effects Of Vitamin K On Neuronal Ferroptosis, Chelsey P. Eighmey
Electronic Theses & Dissertations (2024 - present)
Dementia is a crippling illness affecting millions worldwide causing significant public health burdens with long-term care. The lack of treatment options results in many years of suffering for affected individuals and their loved ones who often become primary caretakers. Decades of study have focused on treating dementia with little-to-no success, so an emphasis is needed on attempting to prevent disease progression altogether. This research explored vitamin K as a potential strategy for prevention of dementia onset or progression through the mechanism of suppressing ferroptosis. Ferroptosis is a type of cell death suggested to contribute to the hallmark traits of Alzheimer’s …
Seeing Anxiety: Ecological Video Ethnography And Simulation To Understand Anxiety And Decision-Making In Dental Care, Mona Nasser, Hannah Drayson, Sally Hanks, Nicholas Peres, Michael Punt
Seeing Anxiety: Ecological Video Ethnography And Simulation To Understand Anxiety And Decision-Making In Dental Care, Mona Nasser, Hannah Drayson, Sally Hanks, Nicholas Peres, Michael Punt
Peninsula Dental School
BACKGROUND: Dental anxiety is a widespread barrier to care, often contributing to appointment avoidance, treatment disruption, and emotional strain for both patients and clinicians. While extensively studied as a psychological trait, less attention has been paid to how anxiety manifests situationally and relationally, through non-verbal, affective, and spatial cues within clinical encounters. Moreover, in certain contexts, such affective signals can intersect with decision-making processes, shaping how patients interpret, engage with, or withdraw from clinical choices.
OBJECTIVE: To explore how anxiety manifests within the micro-choreography of dental encounters, develop a taxonomy of 'anxious tells', and assess the utility of ecological video …
Can The 2025 Nobel Prizes In Physics And Economics Inspire A “Quantum” Turn In Tourism Research?, Waqas Ali
Can The 2025 Nobel Prizes In Physics And Economics Inspire A “Quantum” Turn In Tourism Research?, Waqas Ali
Plymouth Business School
No abstract provided.
Enhancing Market Transparency Through Co-Creation Of Csr And Sustainability Ratings Between Firms, Rating Agencies And Customers, Christopher Agyapong Siaw
Enhancing Market Transparency Through Co-Creation Of Csr And Sustainability Ratings Between Firms, Rating Agencies And Customers, Christopher Agyapong Siaw
Plymouth Business School
No abstract provided.
The Career Choices Of Final Year Nursing Students In The United Kingdom: A Qualitative Study., Kevin Hambridge, Frazer Underwood, Gosia Bettache, Matt Carey, Halil Kaya, Lisa Burrows, Rachel Tims, Christian Brailsford
The Career Choices Of Final Year Nursing Students In The United Kingdom: A Qualitative Study., Kevin Hambridge, Frazer Underwood, Gosia Bettache, Matt Carey, Halil Kaya, Lisa Burrows, Rachel Tims, Christian Brailsford
School of Nursing and Midwifery
Aim: The aim of this study is to explore the career choices of final year under-graduate nursing students in the United Kingdom. Background: Worldwide there is a decreasing number of nurses and in the United Kingdom there is a decreasing amount of nursing students. There is sparce evidence relating to the career's choices of nursing students and reasons for those choices. Obtaining a deeper comprehension of these choices may aid healthcare employers, in partnership with universities, to design the future nursing workforce. Design: A qualitative design was used. Methods: Twenty-one final year under-graduate nursing students from across a range of …
An Evidence Review Of Technology Enabled Social Care In The Uk: Report For Cornwall Health Determinants Research Collaboration, Sheena Asthana, Michael Loizou, Marius Varga, Oliver Beer, Rory Baxter, Kieran Green
An Evidence Review Of Technology Enabled Social Care In The Uk: Report For Cornwall Health Determinants Research Collaboration, Sheena Asthana, Michael Loizou, Marius Varga, Oliver Beer, Rory Baxter, Kieran Green
School of Nursing and Midwifery
The Urgent Need for a Shift from Crisis Intervention to Prevention. As highlighted by the Chief Medical Officer, demographic ageing—particularly acute in coastal areas like Cornwall—necessitates a fundamental shift in care models to allow individuals to live as independently as possible. Currently, the potential of digital technologies to support this aim is not being realised. To maintain wellbeing and reduce demand on statutory services, the system must pivot from reactive crisis management to a greater focus on prevention. While technology can play a pivotal role, it will only succeed if integrated into interoperable, data-driven systems that facilitate early intervention and …
Who Seeks Help? Characteristics Of Doctors Accessing Mental Health Support In England: 4-Year National Review, Rohit Shankar
Who Seeks Help? Characteristics Of Doctors Accessing Mental Health Support In England: 4-Year National Review, Rohit Shankar
Peninsula Medical School
BackgroundMental health difficulties affect the well-being of doctors and compromise the delivery of healthcare. However, large-scale data on doctors’ mental health needs are limited.AimsDescribe patterns of self-referrals for mental health support among doctors in England and explore associations with demographic factors, speciality, neurodevelopmental and mental health indicators.MethodObservational study using data from doctors who self-referred for mental health difficulties to a national service in England over a 4-year period. Logistic regression was used to explore associations between speciality and mental health indicators.ResultsOf the 16 815 doctors who self-referred during the study period, 80% were under the age of 49 and 70.6% …
The Effectiveness Of Digital Therapeutics Intervention In Oral Anticoagulation Management: A Systematic Review And Meta-Analysis, Jiayue Guo, Lili You, Lu Liu, Xitong Jiao, Debasish Kar, Jitendra Jonnagaddala
The Effectiveness Of Digital Therapeutics Intervention In Oral Anticoagulation Management: A Systematic Review And Meta-Analysis, Jiayue Guo, Lili You, Lu Liu, Xitong Jiao, Debasish Kar, Jitendra Jonnagaddala
Peninsula Medical School
Objective: To summarize the key intervention characteristics and evaluate the effectivenessand safety of digital therapeutics (DTx) in patients receiving oral anticoagulation, witheffectiveness evaluated using time in therapeutic range (TTR), thromboembolic events (TEE),and mortality, and safety evaluated based on bleeding events.Patients and Methods: We searched PubMed, Embase, Web of Science, and the CochraneLibrary from inception to June 20, 2025, and identified ten randomized controlled trialsinvolving 7,237 patients. The criteria required studies to assess software-based DTxsupporting anticoagulation management and report effectiveness or safety outcomes. Studyquality was evaluated using the Grading of Recommendations, Assessment, Development,and Evaluation (GRADE) framework, and random-effects models were applied.Results: …
Patient And Practitioner Workshops For An Intellectual Disabilities And Epilepsy Neuropsychiatric Genetic Research Database Register: Ethical Dilemmas For Study Design, Rohit Shankar, Jon Allard, Dannielle Bilkey, Brendan Mclean, Pamela Bowman, Chloe Staples, Lance Watkins, Anna Simpson, Elizabeth Boardman, Sarah Mitchell, Sarah Lennard
Patient And Practitioner Workshops For An Intellectual Disabilities And Epilepsy Neuropsychiatric Genetic Research Database Register: Ethical Dilemmas For Study Design, Rohit Shankar, Jon Allard, Dannielle Bilkey, Brendan Mclean, Pamela Bowman, Chloe Staples, Lance Watkins, Anna Simpson, Elizabeth Boardman, Sarah Mitchell, Sarah Lennard
Peninsula Medical School
BackgroundThere is a need for more research studies focussed on People with ID (PwID) and Epilepsy and for the design of these studies to be shaped by this complex and vulnerable population and those who care for and support them.AimsTo develop understanding as to how a future NHS genetic research database register for PwID and Epilepsy should be conducted in a way which is inclusive, suitable and appropriate for them, their carers and the NHS settings where the research would be undertaken.MethodsThree workshops were completed with 17 formal participants: (1) PwID and Epilepsy (n2); (2) carers of PwID and Epilepsy …
Prevalence And Determinants Of Diabetes-Related Psychological Distress In A Tertiary Care Setting In Tamil Nadu: India: Cross-Sectional Study, Rohit Shankar, Samuel Tromans
Prevalence And Determinants Of Diabetes-Related Psychological Distress In A Tertiary Care Setting In Tamil Nadu: India: Cross-Sectional Study, Rohit Shankar, Samuel Tromans
Peninsula Medical School
BackgroundDiabetes distress, whereby people with diabetes experience distressing psychological symptoms associated with living with their condition, is an emerging problem in India. Diabetes distress leads to self-care deficits, suboptimal glycaemic control (which can lead to increasing risks of complications) and impaired quality of life.AimsTo determine the burden of diabetes distress and its associated factors in an Indian tertiary care centre in Trichy, Tamil Nadu, India, covering a population of 1.25 million.MethodThis prospective observational study involved a structured questionnaire covering demographic and clinical details, which was given to patients. The Diabetes Distress Scale 17 (DDS-17) was used to assess diabetes distress …
Involving Parents In Prevention: A Case Example Of Research And Intervention Development To Improve Financial Well-Being Support, Nick Axford, Gisella Hanley, Rebecca Summers, Kristin Liabo, Amy Bond, Eleanor Bryant, Georgia Smith, Rachel Silcock, Vashti Berry
Involving Parents In Prevention: A Case Example Of Research And Intervention Development To Improve Financial Well-Being Support, Nick Axford, Gisella Hanley, Rebecca Summers, Kristin Liabo, Amy Bond, Eleanor Bryant, Georgia Smith, Rachel Silcock, Vashti Berry
Peninsula Medical School
The adverse effects on parent and child outcomes of poverty and stressors associated with low income are well established. With notable exceptions, however, the potential role of frontline services in improving family financial well-being is underexplored. This article outlines how patient and public involvement (PPI) was initiated early on in research on financial well-being support (FWbS). It illustrates how research can build on and integrate what parents say about services and how to research them. The involvement work was undertaken in one city in part to inform the adaptation of an income maximisation service to be delivered in local children’s …
Measuring Outcomes In Evaluations Of Interventions To Prevent Youth Crime And Violence: Challenges And Potential Solutions, Sajid Humayun, Finlay Green, Helen Downham, Nick Axford
Measuring Outcomes In Evaluations Of Interventions To Prevent Youth Crime And Violence: Challenges And Potential Solutions, Sajid Humayun, Finlay Green, Helen Downham, Nick Axford
Peninsula Medical School
There is a clear imperative to prevent youth crime and violence owing to the significant social and economic costs for individuals involved and wider society. A considerable evidence base for ‘what works’ in this space exists but gaps remain. To address these, it is necessary to evaluate intervention effectiveness. The aim of this article is to explore challenges and potential solutions regarding outcome measurement in such evaluations. To do this we draw on the literature and our experience as evaluators. We argue that outcome selection should be informed by a robust theory of change, and that normally this will mean …
Small-Molecule Therapies Targeting Tumor-Associated Macrophages In Glioma: Mechanisms And Potential, Hua Wang, Heng Luo, Haijian Zhong, Amy Ockleton, Feng Jiang, Renhui Yi, Shaochun Yang, Ming Li
Small-Molecule Therapies Targeting Tumor-Associated Macrophages In Glioma: Mechanisms And Potential, Hua Wang, Heng Luo, Haijian Zhong, Amy Ockleton, Feng Jiang, Renhui Yi, Shaochun Yang, Ming Li
Peninsula Medical School
Glioblastoma, a highly prevalent and aggressive primary brain tumor, is marked by poor prognosis due to the blood-brain barrier and chemoresistance, which limit conventional pharmacotherapy. Recent research has pivoted toward targeting the tumor microenvironment, where tumor-associated macrophages (TAMs) drive gliomagenesis and malignant progression through immunosuppressive signaling. Small-molecule agents targeting TAMs have emerged as promising therapeutics, capable of reprogramming macrophage polarization, modulating immune cell dynamics, and suppressing glioma growth. This review explores the mechanistic roles of TAMs in glioma and evaluates how small-molecule compounds exert antitumor effects via TAM modulation. These insights lay a foundation for developing next-generation TAM-targeted therapies, offering …
Enhancing Offshore Wind Resource Assessment Through Neural Network-Based Hf Radar Data Analysis, Nikolas Martzikos, Matthew Craven, David Walker, Daniel Conley
Enhancing Offshore Wind Resource Assessment Through Neural Network-Based Hf Radar Data Analysis, Nikolas Martzikos, Matthew Craven, David Walker, Daniel Conley
School of Engineering, Computing and Mathematics
The increasing demand for offshore wind energy underscores the need for accurate wind speed estimation to support the design and operation of offshore wind farms. High-Frequency Radar (HFR), a widely used remote sensing technology in oceanographic research, offers promising potential for wind resource assessment, particularly in areas where conventional measurements are limited. This study explores the application of artificial neural networks (ANNs) for offshore wind speed prediction using HFR-derived data, addressing key challenges in model development and training. A key feature of this approach is the use of a decade-long dataset from the Celtic Sea, off the southwest UK coast, …
Usable Authentication: Are We There Yet?, Nathan Clarke, Steven Furnell
Usable Authentication: Are We There Yet?, Nathan Clarke, Steven Furnell
School of Engineering, Computing and Mathematics
With technology increasingly embedded in everyday life, the demand for secure and usable authentication methods has never been greater. Traditional password-based systems continue to dominate, despite well-known usability and security challenges. This paper explores the evolution of user authentication technologies, from secret knowledge and tokens to biometrics and emerging approaches such as Passkeys. It critically evaluates the extent to which usability has been achieved, identifying both successes—such as biometrics integrated into smartphones—and persistent issues, including inconsistent guidance, ecosystem dependence, and accessibility barriers. Drawing on academic and commercial developments, the discussion highlights the growing burden on users who must authenticate across …
Diagnosing Long-Term Divergence In Build Back Better Outcomes In Low- And Lower-Middle-Income Communities, E. A. Opabola, M. Baiguera, A. Raby, T. Rossetto, A. Pomonis, E. Meilianda, Y. Idris, S. Nurdin, K. Adams, D. J. Mcgovern, N. Acikgoz, H. Mistry, F. Marafini
Diagnosing Long-Term Divergence In Build Back Better Outcomes In Low- And Lower-Middle-Income Communities, E. A. Opabola, M. Baiguera, A. Raby, T. Rossetto, A. Pomonis, E. Meilianda, Y. Idris, S. Nurdin, K. Adams, D. J. Mcgovern, N. Acikgoz, H. Mistry, F. Marafini
School of Engineering, Computing and Mathematics
Low-income communities in disaster-prone regions face persistent challenges in translating post-disaster recovery investments into sustained resilience, as they navigate trade-offs among engineering objectives, policy constraints, and evolving socio-economic needs. Despite the widespread adoption of Build Back Better (BBB) principles, evidence on the long-term sustainability of outcomes remains limited, particularly in low- and lower-middle-income contexts. This study examines the sustainability of BBB outcomes in two Indonesian case studies: Banda Aceh (approximately 18 years after the 2004 Indian Ocean tsunami) and Central Sulawesi (approximately 4 years after the 2018 earthquake, liquefaction, and tsunami). Drawing on structured housing assessments, household surveys, semi-structured interviews, …
Investigating The Potential For First Year Residential Field Courses To Facilitate The Establishment Of Teacher-Student Relationships In Biological Sciences Undergraduate Degrees, Anne Plessis, Alison Stokes
Investigating The Potential For First Year Residential Field Courses To Facilitate The Establishment Of Teacher-Student Relationships In Biological Sciences Undergraduate Degrees, Anne Plessis, Alison Stokes
School of Biological and Marine Sciences
Teacher-student relationships (TSRs) in higher education impact many aspects of the student experience, including engagement and performance. However, relatively little is known about the mechanisms of establishment of TSRs, and in particular how these are influenced by specific learning environments and contexts. Here, we undertake an exploratory investigation using first year biological sciences undergraduate residential field courses to examine how this teaching context affected the frequency and nature of teacher student interactions, and consequently the development of TSRs. Data were collected from teacher and student participants using questionnaires and focus groups. We found that interactions during fieldwork took place frequently …
Groundwater Spatial Variability Within An Atoll Island: Assessing Shallow Aquifer Heterogeneity With Geophysical And Physicochemical Measurements, N. I. Tobon-Velazquez, G. Masselink, T. J. O’Hare, R. Bates, F. K.J. Oberle, C. D. Storlazzi, D. C. Conley
Groundwater Spatial Variability Within An Atoll Island: Assessing Shallow Aquifer Heterogeneity With Geophysical And Physicochemical Measurements, N. I. Tobon-Velazquez, G. Masselink, T. J. O’Hare, R. Bates, F. K.J. Oberle, C. D. Storlazzi, D. C. Conley
School of Biological and Marine Sciences
This study examines the spatial variability of shallow groundwater on Dhigelaabadhoo Island using electromagnetic induction surveys, groundwater monitoring, and sediment analyses. The research reveals how variations in island morphology—such as differences in elevation, reef flat width, and sediment composition—affect the spatial distribution of groundwater lenses and the overall aquifer dynamics. Saltwater intrusion is especially pronounced in low elevated areas, with narrow reef flat plate and areas where higher hydraulic conductivity—driven by the presence of coarser sediments—is observed, whereas regions characterized by finer sediments, higher elevation, and wider reef flat plates tend to support more symmetric and less saline groundwater lenses. …
Critical Success Factors For An Effective Security Risk Management Program: An Exploratory Case Study, Jason A. Williams, Humayun Zafar, Saurabh Gupta
Critical Success Factors For An Effective Security Risk Management Program: An Exploratory Case Study, Jason A. Williams, Humayun Zafar, Saurabh Gupta
Faculty Articles
This paper evaluates the perceived effectiveness of the security risk management (SRM) programs at a Fortune 500 firm. Layers of management and staff participated in the study. Perceived effectiveness of their SRM programs was based on nine critical success factors (CSFs). Interviews confirmed six initial CSFs (Executive Management Support, Organizational Maturity, Open Communication, Risk Management Stakeholders, Team Member Empowerment, and Holistic View of an Organization) that were extracted from the literature. They were confirmed and synthesized with three additional CSFs (Security Maintenance, Corporate Security Strategy, and Human Resource Development). Implications for SRM are discussed.
Affirmatively Misled: The Commutation Instruction That Distorted Louisiana’S Death Penalty, G. Ben Cohen
Affirmatively Misled: The Commutation Instruction That Distorted Louisiana’S Death Penalty, G. Ben Cohen
Akron Law Faculty Publications
In 1997, Louisiana voters amended the state constitution to mandate that capital juries be instructed on the governor’s power to commute life and death sentences. This amendment, urged by the Louisiana District Attorneys Association, followed a Louisiana Supreme Court ruling that found an earlier clemency instruction violated the state constitution. The instruction was fundamentally false. Louisiana governors, it turns out, lacked the unilateral authority to commute sentences; such actions require a favorable vote from the Parole Board. This reality became starkly clear in 2023, when the clemency petitions of fifty-six condemned prisoners—many sentenced by juries affirmatively given this instruction—were terminated …
Professional Quality Of Life Among Medical Surgical And Telemetry Registered Nurses, William Lim, Emy-Lee Marie Anglo Ricafrente, Jenny Carrillo
Professional Quality Of Life Among Medical Surgical And Telemetry Registered Nurses, William Lim, Emy-Lee Marie Anglo Ricafrente, Jenny Carrillo
Publications 2026-present
No abstract provided.
06.01.02. Antillean Nighthawk, Chordeiles Gundlachii, M. Davis, Ann Hodgson, Florida Ornithological Society
06.01.02. Antillean Nighthawk, Chordeiles Gundlachii, M. Davis, Ann Hodgson, Florida Ornithological Society
06.01. <i>Caprimulgidae</i> - Nightjars and Allies
The Antillean Nighthawk is a widespread summer resident across the Greater Antilles and is rare but regular in the Florida Keys and extreme southern Florida mainland.
Activist Judicial Restraints, Michael Gentithes
Activist Judicial Restraints, Michael Gentithes
Akron Law Faculty Publications
For decades, jurists and scholars have touted the virtues of judicial restraint—a characteristic of judges who only adjudicate issues they are competent to resolve, thereby avoiding political thickets and preserving their authority. Judicial restraint is ingrained in justiciability doctrines that emanate from Article III of the Constitution. When applied evenhandedly, standing requirements, the political question doctrine, and prudential manageability prerequisites to litigation help the Court maintain an appropriately restrained docket.
The Roberts Court falls well short of this restrained ideal in potentially dangerous and destructive ways. The Court has changed justiciability doctrines into “activist judicial restraints” that, rather than avoiding …
The Inward Gaze: Byung-Chul Han's Achievement-Subjectivity In David Foster Wallace's Short Fiction, Ivan Marquez
The Inward Gaze: Byung-Chul Han's Achievement-Subjectivity In David Foster Wallace's Short Fiction, Ivan Marquez
All Student Theses and Dissertations
David Foster Wallace stated that the aim of his fiction and art was to reflect what it meant to be alive and form a relationship with the reader. In "E Unibus Plurum", Wallace posited that the tenets of Post-Modern fiction were once used to criticize the hypocrisies of the 1950's and 60's American had been subsumed by television and were no longer effective tools of criticism. Wallace argues for a move away from irony and stunt pilotry of postmodern fiction towards a fiction which espoused "single entendre values" (Wallace 192). While Wallace advocated for a return to more traditional story-telling, …
Unseen Motherhood, Kylie Zieminski
Unseen Motherhood, Kylie Zieminski
All Student Theses and Dissertations
Unseen Motherhood is a series of photographs that shows what first-time motherhood is really like, starting with pregnancy and going through birth and everything after. I did not want to just show the happy or perfect moments. I wanted to capture the hard parts, the big feelings, and how much a person's identity can change.
There are eighteen black-and-white photographs in this series, all showing my twin sister as she goes through becoming a mother. These images follow her before, during, and after birth. I wanted to show that motherhood is more than just one happy photograph.
I based this …
Binding The Visual Experience Of Law, Nicholas Mignanelli
Binding The Visual Experience Of Law, Nicholas Mignanelli
Articles, Chapters in Books and Other Contributions to Scholarly Works
No abstract provided.
Psychometric Properties Of A Novel Affective Bias Task And Its Application In Clinical And Nonclinical Populations, Prathik Kalva, Kourtney Kanja, Brian A Metzger, Xiaoxu Fan, Brian Cui, Bailey Pascuzzi, John Magnotti, Madaline Mocchi, Raissa Mathura, Kelly R Bijanki
Psychometric Properties Of A Novel Affective Bias Task And Its Application In Clinical And Nonclinical Populations, Prathik Kalva, Kourtney Kanja, Brian A Metzger, Xiaoxu Fan, Brian Cui, Bailey Pascuzzi, John Magnotti, Madaline Mocchi, Raissa Mathura, Kelly R Bijanki
Faculty, Staff and Students Publications
To mitigate limitations in self-reported mood assessments, we introduce a novel affective bias task (ABT). The task quantifies instantaneous emotional state by leveraging the phenomenon of affective bias, in which people interpret external emotional stimuli in a manner consistent with their current emotional state. This study establishes task stability in measuring and tracking depressive symptoms in clinical and non-clinical populations. Initial assessment in a large non-clinical sample established normative ratings. Depressive symptoms were tracked relative to task performance in a non-clinical sample, as well as in a clinical cohort undergoing surgical evaluation for severe epilepsy. In both cohorts, a stronger …
Brain Death Versus Circulatory Death: How Functional Warm Ischemia And Cold Storage Impact Myocardial Membrane Repair In Human Donor Hearts, Shiyi Li, Rishav Bhattacharya, Abdussalam E Elsenousi, Katherine V Nordick, Adel M Hassan, Syed B Peer, Camila Hochman-Mendez, Todd K Rosengart, Kenneth K Liao, Nandan K Mondal
Brain Death Versus Circulatory Death: How Functional Warm Ischemia And Cold Storage Impact Myocardial Membrane Repair In Human Donor Hearts, Shiyi Li, Rishav Bhattacharya, Abdussalam E Elsenousi, Katherine V Nordick, Adel M Hassan, Syed B Peer, Camila Hochman-Mendez, Todd K Rosengart, Kenneth K Liao, Nandan K Mondal
Faculty, Staff and Students Publications
This study compares myocardial injury responses in human donor hearts from donation after brain death (DBD) and donation after circulatory death (DCD), with a focus on myocardial membrane integrity, pyroptosis, and damage. Unlike DCD hearts, which are exposed to varying durations of functional warm ischemic time (fWIT), DBD hearts, which are never subjected to warm ischemia, served as controls. A total of 24 human hearts were procured, consisting of 6 from the DBD group and 18 from the DCD group. All procured hearts were placed in cold normal saline and stored for up to 6 h. Left ventricular biopsies were …