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Pathogenic Oral Microbiota Abundance Is Associated With Reduced Bite Force In Patients With Periodontitis, Chih-Chieh Wen, Thu Ya Linn, Ting-Yi Renn, Hui Yin Nam, Chia-Chen Hsu, Yi-Jen Lin, Yi-Fan Wu, Wei-Jen Chang

Journal of Dental Sciences

Background/purpose: Periodontitis leads to tissue destruction and functional impairment, but the interplay between microbiota, clinical parameters, and biomechanics remains unclear. This study aimed to quantitatively correlate specific oral microbial signatures and clinical inflammatory indicators with bite force in patients with periodontitis.

Materials and methods: Fifteen patients with stage III-IV periodontitis and 15 periodontally healthy controls were recruited. Clinical parameters (Probing Depth, Clinical Attachment Loss, Bleeding on Probing, Plaque Index) and MBF (pressure-sensitive film) were recorded. Supragingival plaque was analyzed through 16S rRNA gene sequencing (PacBio SMRT) to determine microbial composition. Correlation analyses were performed.   

Results: The periodontitis …

Rigorous Validation Of Machine Learning Models For Orthodontic Extraction Prediction Using Nested Cross-Validation And Smotenc-Integrated Pipelines., Anh Thi-Ngoc Do, Hung Trong Hoang, Thuy-Trang Thi Ho, Hieu Ngoc Le

Journal of Dental Sciences

Background/purpose: Machine learning (ML) in orthodontics often suffers from optimistic bias due to data leakage and improper handling of class imbalance. This study implemented and evaluated a production-grade validation framework - nested cross-validation (CV) - for three distinct algorithm classes (logistic regression, random forest, and gradient boosting) using a consensus-labeled orthodontic dataset.

Materials and methods: A retrospective dataset of 500 patients (334 non-extraction/166 extraction) was curated with 41 processed features. Two stratified split protocols (70/30 and 80/20) were evaluated to assess model robustness. To ensure methodological rigor, a 5-fold outer/3-fold inner nested cross-validation was implemented. Crucially, SMOTENC (synthetic minority over-sampling …

Development Of A Risk Scoring System For Predicting Post-Extraction Medication-Related Osteonecrosis Of Jaws: A Derivation And Validation Cohort Study, Ling-Ying Wei, Ching-Ming Chiu, Sang-Heng Kok, Hung-Ying Lin, Wei-Yih Chiu, Hao-Hong Chang, Shih-Jung Cheng, Jang-Jaer Lee

Journal of Dental Sciences

Background/purpose: Although risk factors for medication-related osteonecrosis of the jaw (MRONJ) are known, clinical assessment prior to dental extraction remains largely subjective. We aimed to develop and externally validate a simple clinical risk scoring system to predict post-extraction MRONJ in osteoporotic patients receiving antiresorptive therapy (ART) and support evidence-based clinical decision-making.

Materials and methods: This retrospective cohort study used a derivation cohort (N = 1,067 extractions, 2003‒2022) to develop a 5- to 16-point risk score system based on five predictors (age ≥ 75, ART duration ≥ 24 months, bisphosphonate use, drug interruption < 3 months, and extraction site). The model was validated in an independent cohort (N = 928 extractions, 2022–2024) using a pre-defined ≥12 cut-off. Performance metrics included the area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).

Results: MRONJ prevalence was lower in the validation …

Prevalences Of Vitamin B12 Deficiency, Pernicious Anemia, Macrocytosis, And Hyperhomocysteinemia In 532 Serum Gastric Parietal Cell Antibody-Positive Oral Mucosal Disease Patients, Yu-Hsueh Wu, Yi-Pang Lee, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun, Chun-Pin Chiang

Journal of Dental Sciences

Background/purpose: Our previous studies found the serum gastric parietal cell antibody (GPCA) positivity in 12.3% to 26.7% of atrophic glossitis (AG), burning mouth syndrome (BMS), and oral lichen planus (OLP) patients. This study assessed whether GPCA-positive oral mucosal disease (GPCA⁺OMD) patients (including 284 AG, 109 BMS, and 139 OLP patients) had significantly higher frequencies of microcytosis, macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than healthy control subjects (HCSs) or GPCA-negative OMD (GPCAˉOMD) patients.

Materials and methods: The mean corpuscular volume, blood Hb, and serum iron, vitamin B12, homocysteine, and GPCA levels were measured and compared …

Dynamic Navigation-Assisted Implant Placement For The Jaw-In-A-Day Mandibular Reconstruction, Ni Lin, Min-Yi Sung, Yu-Cheng Cheng

Journal of Dental Sciences

No abstract provided.

Influence Of All-On-4 Implant Angles On Stability And Crestal Bone - A Finite Element Optimization Analysis,, Jing-Jie Chen, Chen-Sheng Chen

Journal of Dental Sciences

No abstract provided.

Poly-Ε-Caprolactone/Multi-Wall Carbon Nanotube Composites As Osteoinductive Scaffolds For Alveolar Bone Regeneration,, Chien-Yang Yeh, Firdiansyah Rasyid

Journal of Dental Sciences

No abstract provided.

Integrated Analysis Of Single-Cell And Bulk Rna-Sequence Data Reveal Plasma Dendritic Cell-Related Diagnostic Model For Sjögren's Syndrome Based On Machine Learning,, Jinhao Zhang, Chunye Zhang

Journal of Dental Sciences

No abstract provided.

Comparative Effects Of Plasma Activation And Monomer Infiltration On The Surface Characteristics And Wettability Of 3d-Printed Permanent Crown Resin,, Pyi Phyo Win, Szu-Yu Lai

Journal of Dental Sciences

No abstract provided.

In Vitro Characterization Of Tooth-Derived And Dentin-Derived Graft Particles: Comparative Analysis Of Particle Size, Mineral Composition, And Cytotoxicity, Vinh Quang Luu, Nhan Duc Le

Journal of Dental Sciences

No abstract provided.

Risk Factors For Surgical-Site Infections In Oral Cancer Patients With Microvascular Free Flap Reconstruction–A Retrospective Study In A Single Medical Center In Taiwan, Pei-Yin Chen, Yu-Wei Chiu

Journal of Dental Sciences

No abstract provided.

Optogenetic Control Of Odontoblastic Differentiation In Dental Pulp Stem Cells (Dpsc), Francesco Torelli

Journal of Dental Sciences

No abstract provided.

Craniofacial And Dental Arch Morphological Changes In Pediatric Obstructive Sleep Apnea Syndrome Following Rapid Maxillary Expansion, Yu-Hao Liu, Yu-Shu Huang, Yi-Jing Hwang

Journal of Dental Sciences

No abstract provided.

Integrating Image Processing And Deep Learning Framework For Automatic Supernumerary Tooth Detection On Occlusal Radiographs, Jui-An Fu, Chia-Lin Hsu

Journal of Dental Sciences

No abstract provided.

Activities Of Dental Hygienists Registered In The Disaster Relief System Of The Japan Dental Hygienists’ Association In The 2024 Noto Peninsula Earthquake, Hitomi Suzuki, Kumiko Sugimoto

Journal of Dental Sciences

No abstract provided.

Deciphering Novel Targets In Salivary Gland Pleomorphic Adenoma By Integrating Plasma Proteomics And Parotid Transcriptomics Analyses, Yuchen Fan, Suning Mao

Journal of Dental Sciences

No abstract provided.

Mesenchymal Stem Cells Derived From Gingiva Normoxic Or Hypoxic-Preconditioning Allogenous Transplantation Affect Orthodontic Tooth Movement In Vivo, Alexander Patera Nugraha, Guang Hong

Journal of Dental Sciences

No abstract provided.

Risk Of Pneumonia And Mortality After Routine Dental Scaling In Patients With Moderate-To-Severe Cerebral Palsy: A Nationwide Cohort Study, Li-Wei Ou-Yang, Ya-Ting Chang

Journal of Dental Sciences

No abstract provided.

Strategy Of Allying General Dentistry Staffs Into Pre-Anesthetic Dental Assessment Reduces Perioperative Dental Injury Risk During General Anesthesia, Cheng Lu, Mei-Chun Chen

Journal of Dental Sciences

No abstract provided.

Osteoclast-Derived Exosomes Promote Medication-Related Osteonecrosis Of The Jaw By Delivering Glycorna To Disrupt The Blood–Lymphatic Vascular Network, Jiankang Zhang, Junming Tao

Journal of Dental Sciences

No abstract provided.

Oral Health-Related Quality Of Life And Diabetes Outcomes: Evidence From A Nationally Representative U.S. Sample, Hsueh-Fen Chen, Jou-Hsun Lee

Journal of Dental Sciences

No abstract provided.

Vanadium-Functionalized Methyl Methacrylate-Based Primer Enhances Self-Curing And Bonding Of Resin Cement To Polyetheretherketone Restorations, Takeru Kondo, Jun Sato

Journal of Dental Sciences

No abstract provided.

A Visualized Ai-Assisted Framework For Pre-Surgical Evaluation Of Implant Pathways On Periapical Radiographs, Yuan-Jin Lin, Chiung-An Chen

Journal of Dental Sciences

No abstract provided.

Comparative In Vivo Study Of 3d-Printed Composite Bioceramic Scaffolds Fabricated By Distinct Pre-Processing Methods, Yu-Ting Li, Ju-Hsuan Yang

Journal of Dental Sciences

No abstract provided.

Self-Perceived Attractiveness Of Labiomental Angles In Taiwanese And Caucasian Males: A Comparative Study Before And After Orthodontic Education Among Dental Students, Shih-Chieh Chen, Chun-Ming Chen

Journal of Dental Sciences

No abstract provided.

Fluvastatin Enhances Healing Of Medication−Related Osteonecrosis Of The Jaw (Mronj) Via Macrophage Polarization In A Rat Mronj−Like Model, Moa Tazaki, Koma Sanda

Journal of Dental Sciences

No abstract provided.

Retrospective Accuracy Comparison Of Marker-Based And Marker-Free Registrations Using Dynamic Implant Navigation, Zhiyi Zhu, Shikai Zhao

Journal of Dental Sciences

No abstract provided.

Synergistic Effect Of Combined Cisplatin And Rosmarinic Acid On Apoptosis And Migration Of Head And Neck Cancer Cell Lines, Suppanut Jongjitaree, Paopanga Kokilakanit

Journal of Dental Sciences

No abstract provided.

Craniofacial And Airway Changes After Skeletal Class Iii Orthognathic Surgery: A Machine Learning Study, Zay Yar Linn, Johnson Hsin-Chung Cheng

Journal of Dental Sciences

No abstract provided.

Effect Of Horizontal Dimensional Malocclusions On Smile Changes In Frontal, Lateral, And Oblique Views Before And After Orthodontic Treatment, Johnson Hsin-Chung Cheng, Sarah Jia-Min Lin

Journal of Dental Sciences

No abstract provided.