Digital Commons Network^™

Exosomes Derived From Bone Substitute-Induced Gingival Mesenchymal Stem Cells Promote Angiogenesis, Chongyu Shen, Zheng Guan, Rui Chu, Zhengyin Li, Jiangting Lu, Liangkun Xie

Journal of Dental Sciences

Background/purpose: In certain clinical bone grafting scenarios, bone substitutes frequently interface with the adjacent soft tissues. This study aimed to investigate whether deproteinized bovine bone mineral (DBBM) and coralline hydroxyapatite (CHA) induce paracrine responses in human gingival mesenchymal stem cells (GMSCs), thereby altering the pro-angiogenic capacity of their derived exosomes, and to profile specific cargo alterations.

Materials and methods: Exosomes were isolated from GMSCs co-cultured with DBBM (DBBM-G-EXO) or CHA (CHA-G-EXO), while native GMSCs-derived exosomes (G-EXO) were collected as controls. The angiogenic effects of these exosomes on human umbilical vein endothelial cells (HUVEC) were evaluated via cell proliferation, scratch wound …

Silencing The Mir-132/Sirt1 Axis Suppresses Nlrp3 Inflammasome Activation And Myofibroblast Differentiation In Oral Submucous Fibrosis, Ming-Yung Chou, Min Yee Ng, Yi-Wen Liao, Chuan-Hang Yu, Cheng-Chia Yu, Sin-Jia Tseng

Journal of Dental Sciences

Background/purpose

Oral submucous fibrosis (OSF) is a chronic oral potentially malignant disorder characterized by progressive extracellular matrix deposition, myofibroblast activation, oxidative stress, and inflammatory signaling. However, the upstream microRNA-mediated mechanisms linking fibrogenesis and NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome activation remain unclear. This study investigated the role of the miR-132/sirtuin 1  (SIRT1) axis in OSF-associated fibrotic and inflammatory responses.

Materials and methods

miR-132 expression was examined in OSF tissues, normal tissues, primary buccal mucosal fibroblasts (BMFs), and fibrotic buccal mucosal fibroblasts (fBMFs) using RNA sequencing and quantitative real-time PCR. Patient-derived fBMFs were transfected with a miR-132 inhibitor …

A Scientometric Study On Research Trends And Characteristics Of Kimura Disease, Zhongjing Lv, Yiming Luo, Wei Liu, Jian Yuan

Journal of Dental Sciences

Background/purpose: Kimura disease (KD) is an idiopathic condition that presents as a chronic, benign inflammatory disorder, typically affecting the head and neck region. The purpose of this study was to analyze the scientometric characteristics and research trends of KD.

Materials and methods: All the papers on KD were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2012 and after 2012 in the analysis of research trends.

Results: There were 925 papers on KD, with total citations of 10,821 and the h index of 47. Eosinophilia, lymphadenopathy, nephrotic syndrome, angiofollicular lymph node hyperplasia, …

Anemia, Hematinic Deficiencies, And Gastric Parietal Cell Antibody Positivity In Recurrent Aphthous Stomatitis Patients With Or Without Hyperhomocysteinemia, Yi-Ping Wang, Yu-Hsueh Wu, Yi-Pang Lee, Julia Yu-Fong Chang, Andy Sun, Chun-Pin Chiang

Journal of Dental Sciences

Background/purpose: Our previous study found that 42 of 430 recurrent aphthous stomatitis (RAS) patients have hyperhomocysteinemia. This study assessed whether these 42 RAS patients with hyperhomocysteinemia (hyperhomocysteinemia/RAS patients) had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than 388 RAS patients without hyperhomocysteinemia (non-hyperhomocysteinemia/RAS patients) or 430 healthy control subjects.

Materials and methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 42 hyperhomocysteinemia/RAS patients, 388 non-hyperhomocysteinemia/RAS patients, and 430 healthy control subjects were measured and compared.

Results: We found that 42 hyperhomocysteinemia/RAS patients had significantly …

Very Early Interceptive Management Of Class Iii Malocclusion In Primary Dentition Using A Prefabricated Functional Education Appliance: Preliminary Clinical Observations, Thi Ngoc Anh Do, Thi Huong Le, I-Ta Lee, Tong-Hsien Chow, Pao-Chang Chiang, Thi Thuy Tien Vo

Journal of Dental Sciences

Background/purpose: Class III malocclusion with anterior crossbite in primary dentition may progress and complicate future orthodontic treatment. This short communication presents preliminary clinical observations of very early interception using a prefabricated functional education appliance.

Materials and methods: Three children aged 4 to 6 years with dental, functional, or mild skeletal class III malocclusion were treated using a prefabricated removable functional education appliance worn at night, with regular follow-up.

Results: In the dental class III case, anterior crossbite was corrected within 9 months and remained stable at the 2-year follow-up. In the functional class III case, anterior crossbite and mandibular shift …

Artificial Intelligence In Dentistry: A Cross-Domain Bibliometric Analysis Of Technologies, Functional Applications, And Dental Specialties, Yinghui Yang, Cheng-Chia Yu, Min Yee Ng

Journal of Dental Sciences

Background/purpose: Artificial intelligence is increasingly applied in dentistry across diagnosis, prediction, treatment planning, education, and patient communication. This study aimed to provide a structured cross-domain overview of dental AI research by integrating AI technologies, functional applications, and dental specialties within one bibliometric framework.

Materials and methods: AI-related dental publications from 2016 to 2026 were retrieved from the Web of Science Core Collection. Original and review articles were screened and classified by AI technology, functional application, and dental specialty. Bibliometric mapping, collaboration analysis, keyword co-occurrence, and heatmap-based cross-domain visualization were performed.

Results: A total of 920 publications were included. Publication …

Oral Health Knowledge Across Cultural Boundaries: A Physiology And Hygiene Textbook From The Tamsui Middle School During The Japanese Colonial Period, Hung-Lun Pan, Feng-Chou Cheng, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

A Scientometric Study On Research Trends And Characteristics Of Lymph Node Metastasis In Oral Cancer, Linjian Huang, Xiaocui Tong, Wei Liu, Xinyu Zhang

Journal of Dental Sciences

Background/purpose: Cervical lymph node metastasis (LNM) is the most critical prognostic factor in oral cancer (OC) patients. The purpose of this study was to analyze the scientometric characteristics and research trends of LNM in OC.

Materials and methods: All the papers on LNM in OC were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2016 and after 2016 in the analysis of research trends.

Results: There were 946 papers on LNM in OC, with total citations of 21,154 and the h index of 70. The trend of clinical aspect including lymph …

Application Of Medical Imaging Examinations For Temporomandibular Disorders Under Taiwan's National Health Insurance System, Feng-Chou Cheng, Mu-Hsiung Chen, Yu-Ling Wu, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Light-Curing Staining Materials And Application Techniques For Dental Resin Restorations, Fu-Chuan Tsai, Kuo‑Ning Ho, Yu-Chieh Lin, Wei-Chun Lin

Journal of Dental Sciences

No abstract provided.

Topical Fluoride Treatment For Irradiated Head And Neck Cancer Patients Under Taiwan's National Health Insurance System, Feng-Chou Cheng, Mu-Hsiung Chen, Sheau-Jing Yu, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Microsurgical Management Of Non-Union Mid-Root Fractures In Endodontically Treated Maxillary Incisors: A Case Report With 2-Year Follow-Up, Saeed Asgary

Journal of Dental Sciences

No abstract provided.

The Evolution Of Artificial Intelligence And Deep Learning In Removable Partial Denture Design, Fu-Chuan Tsai, Hsin-Hua Chou, Takashi Saito, Wei-Chun Lin

Journal of Dental Sciences

No abstract provided.

The Clinical Potential Of Cone-Beam Computed Tomography Image Segmentation In Dentistry, Hsin-Hua Chou, Takashi Saito, Chih-Kai Huang, Wei-Chun Lin

Journal of Dental Sciences

No abstract provided.

Virtual Patient Technology Enabled The Reconstruction Of Craniofacial Hard And Soft Tissues Through The Integration And Superimposition Of Multimodal Dental Imaging Datasets, Hsin-Hua Chou, Kuo‑Ning Ho, Takashi Saito, Wei-Chun Lin

Journal of Dental Sciences

No abstract provided.

Roles And Functions Of The Dental Division At The National Taiwan University Cancer Center, Feng-Chou Cheng, Yu-Jie Shen, Shu-Yu Liu, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Exploring Exhibited Works On Dentistry-Related Topics At The Student Science Fair Projects In Taiwan From 1970 To 2025, Mei-Huei Li, Feng-Chou Cheng, Kun-Ming Lien, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Ruptured Silicone Cheek Implant Mimicking Odontogenic Infection: A Diagnostic Pitfall, Kimiko Ohgi, Tomoko Shiraishi, Toyohiro Kagawa, Yasunori Yoshinaga

Journal of Dental Sciences

No abstract provided.

Radiographic Signs Of Numb Chin Syndrome As An Initial Indicator Of Burkitt Lymphoma: A Case Report, Yu-Hsiang Tang, Meng-Ling Chiang, Jyh-Kwei Chen

Journal of Dental Sciences

No abstract provided.

Maxillary Furcation-Involved Class Ii Subclass B Molar With Advanced Distal Vertical Bone Defect Treated By Er:Yag Laser-Assisted Comprehensive Periodontal Pocket Therapy Under A Microscope: A Case Report, Taichen Lin, Yoichi Taniguchi, Koji Mizutani, Akira Aoki

Journal of Dental Sciences

No abstract provided.

Recurrent Maxillary Medication-Related Osteonecrosis Of The Jaw With Maxillary Sinusitis In An Edentulous Patient: A Possible Bidirectional Relationship, Wun-Ting Lin, Yu-Nung Lee, Yu-Fen Yen, Ken-Chung Chen

Journal of Dental Sciences

No abstract provided.

Corrigendum To "Human Umbilical Cord Mesenchymal Stem Cells Secretome And Nanoemulsion Propolis Combination Ameliorate Osteoclastogenesis In Lipopolysaccharide-Induced Osteolysis In Hyperglycemia Rats"

Journal of Dental Sciences

No abstract provided.

Comparative Life Cycle Assessment Of End-Of-Life Crystal Silicon Photovoltaic Panels: Recovery Methods And Extended Life In Agricultural Application, Patima Chaichana, Vacharaporn Soonsin, Nattapong Tuntiwiwattanapun

Applied Environmental Research

The increasing deployment of crystalline silicon (c-Si) photovoltaic (PV) panels has raised concerns about their waste management. This study evaluated management strategies for discarded c-Si PV panels in Thailand, integrating environmental and economic analyses. Life cycle assessment (LCA) and cost-effectiveness analysis (CEA) were applied. The LCA can be divided into 2 parts: (1) secured landfill vs decentralized recycling by existing facilities vs centralized full recovery and (2) reusing PV panels in agricultural applications. The results revealed that secured landfills were the most environmentally burdensome (34.43 Pt), whereas centralized recycling achieved net benefits (-211.93 Pt) through emission reductions and recovery of …

Life Cycle Assessment Of Co2-To-Methanol: Comparative Evaluation Of Direct And Alcohol-Assisted Hydrogenation Routes, Chayet Worathitanon, Naphat Chansonthi, Pawat Pinthong, Kritsana Suwanamad, Viganda Varabuntoonvit

Applied Environmental Research

The increasing severity of global warming, primarily driven by greenhouse gas emissions, underscores the urgent need for CO2 reduction and utilization strategies. Converting CO2 into methanol presents a promising approach, as methanol serves both as a fuel and a feedstock in various industries. This study evaluates the life cycle environmental impacts of three methanol production routes: (1) direct CO2 hydrogenation, (2) ethanol-assisted CO2 hydrogenation, and (3) propanol-assisted CO2 hydrogenation. Two energy scenarios are considered: conventional energy and wind power. Process simulations were performed using Aspen Plus V.14, and inventories were analyzed through Life Cycle Assessment (LCA) using the ReCiPe 2016 …

Unveiling Microplastic Removal And Characteristics In Wastewater From Two Municipal Wastewater Treatment Facilities In Indonesia, Nurul Setiadewi, Prayatni Soewondo, Cynthia Henny

Applied Environmental Research

Wastewater treatment plants (WWTPs) are considered an entrance pathways for microplastic (MP) pollution in aquatic environments. This study reveals the removal and characteristics of MPs in wastewater from two municipal WWTPs in Indonesia. The influent contained 17.1 ± 5.65 particles L-1 (WWTP A) and 15.45 ± 4.31 particles L-1 (WWTP B), whereas the effluent contained 1.41 ± 0.01 and 1.5 ± 0.16 particles L-1. The removal efficiency was 91.75% for WWTP A and 90.32% for WWTP B, with no statistically significant difference (p > 0.05). WWTP A employed advanced treatment units, whereas WWTP B used a conventional pond-based system. MPs were …

Assessment Of The Influence Of Human Activities On The Occurrence Of Forest Fires In Thailand Via Multiple Linear Regression (Mlr), Sittipong Ruktamatakul, Jirarat Insuk, Benjaporn Pinwongpet, Sarisa Ruktametakul, Pornpis Yimprayoon

Applied Environmental Research

Forest fires represent one of the most critical environmental challenges in Thailand, with impacts varying depending on forest type, fuel characteristics, terrain conditions, fire intensity, and the frequency of fire occurrence on the same landscape. While forest fires can contribute to ecosystem degradation, biodiversity loss, and the depletion of natural resources, such effects are not uniformly severe across all forest ecosystems. Understanding the human-induced factors contributing to forest fire occurrence is crucial for developing effective prevention strategies and promoting sustainable forest management. This study aimed to identify the anthropogenic factors influencing forest fire areas in Thailand via multiple linear regression …

Effect Of Chromium Doping On The Uv- And Sunlight-Driven Photocatalytic Performance Of Srtio3, Ro’Ikhatul Jannah, Dianisa Khoirum Sandi, Fahru Nurosyid, Risa Suryana, Didier Fasquelle, Yofentina Iriani

Applied Environmental Research

Chromium (Cr)-doped strontium titanate (SrTiO3, STO) photocatalysts with compositions of SrTi1-xCrxO3 (x = 0, 5, and 10%) were prepared via the coprecipitation method. This study aimed to investigate the effects of Cr doping on structural, morphological, and optical properties. Furthermore, this work aimed to examine the photocatalytic performance of pure and Cr-doped STO against methylene blue (MB) degradation under ultraviolet (UV) and sunlight exposure. X-ray diffraction confirmed the formation of the cubic STO phase and the insertion of the Cr dopant in the STO structures. Furthermore, Cr doping reduced the lattice constant, crystallite size, and average particle size and narrowed …

Fabrication Of Acid-Modified Corn Plant By-Product-Based Biochar For Efficient Adsorption Of Sulfamethoxazole From Aqueous Solutions, Thi An Hang Nguyen, Thi Duyen Le, Thi Hang Bui

Applied Environmental Research

Antibiotic pollution is of great interest owing to growing concerns about antibiotic resistance worldwide. This study aims to fabricate acid-modified biochar (CBM-A) from corn plant byproducts (CRs) for sulfamethoxazole (SMX) adsorption in aqueous solutions. CBM-A was synthesized via pyrolysis at 700 °C and modified with 14% H3PO4. Kinetics, isotherms, and thermodynamics were investigated in combination with material characterization to elucidate the adsorption behaviors and mechanisms. The results showed that pyrolysis and acid modification effectively enhanced SMX adsorption by CR because of the increased number of binding groups, specific surface area, and porosity. SMX adsorption on CBM-A was optimized at a …

Blue Carbon Stock Assessment And Climate Resilience Potential Of Mangrove Forest In Hung Thang Commune, Vietnam, Hla Phong Ko, Pham Hong Tinh, Nguyen Thuy Duong

Applied Environmental Research

Mangrove forests are vital blue carbon sinks that contribute to climate change mitigation and coastal resilience. This study assessed the carbon stock and spatial‒temporal dynamics of a mangrove forest in Hung Thang commune, Hai Phong Province, Vietnam, via a combination of field measurements, soil organic carbon (SOC) analysis, and normalized difference vegetation index (NDVI)-based remote sensing models. The results revealed that mangroves in the Hung Thang community store an average of 87.42 tC ha-1, with SOC accounting for approximately 19% of the total carbon. A generalized additive model (GAM) analysis revealed a consistent increase in carbon stocks between 1996 and …

Fabrication Of Urea With Amorphous Silica To Increase Rice Growth In Saline Soils, Thi Ha Chi Nguyen, Thi Hang Thuc Ha, Minh Phuong Nguyen, Ngoc Chuc Pham, Quang Bac Nguyen, Nguyen Huy Tuan Do, Ngoc Nhiem Dao, Trung Kien Nguyen

Applied Environmental Research

In recent decades, the decrease in rice cultivation areas in Vietnam, particularly in the Mekong River Delta, caused by climate change and soil salinization, has posed serious challenges for sustainable development. In addition to irrigation and agronomic practices, fertilizers that sustain rice growth under saline conditions play a crucial role in improving crop productivity. Amorphous silica has been reported to increase plant tolerance to drought, salinity, and heavy metal stress. In this study, nanosilica-coated urea (UCS) fertilizers were synthesized by coating urea granules with 1–5 wt% amorphous silica. The products were characterized by SEM, XRD, FTIR, TG‒DSC, and EDX to …