Digital Commons Network^™

Freeze-Dried, Not Frozen: Lyophilized Mesenchymal Stromal Cell-Derived Extracellular Vesicles And Therapeutic Function In Neuroinflammatory Models, Janet R Ashley, Aidan M Collier, Scott D Olson, Charles S Cox

Faculty, Staff and Student Publications

Background: Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) offer a promising acellular therapy for immune modulation, but clinical translation is hindered by variability and storage constraints. Lyophilization (freeze-drying) could enable shelf-stable EV therapeutics, although its effects on biological activity remain incompletely defined.

Study design: We compared the immunomodulatory effects of frozen and lyophilized EVs from bone marrow (BM), adipose tissue (AD), and umbilical cord (UC) MSCs using lipopolysaccharide-stimulated rodent splenocytes and microglial models and human peripheral blood mononuclear cells (PBMCs). Variables included batch scale (small vs large), cytokine priming, and MSC source. Tumor necrosis factor alpha (TNF-α) secretion was measured …

Grading Melanocytic Dysplasia: Updated Histopathologic Criteria, Christopher R Shea, Victor G Prieto, Catherine M Shachaf, Scott R Florell

Faculty, Staff and Student Publications

Dr. Martin C. Mihm, Jr.'s innovative work on the dysplastic nevus achieved a milestone in his chapter in the World Health Organisation Classification of Skin Tumours (WHO-C). WHO-C presents a dichotomous classification (high-grade versus low-grade dysplastic nevi) and a quantitative metric to assess melanocytic nuclear enlargement. The Duke classification is a related approach that provides mostly quantitative histopathologic criteria for dysplastic nevi and gives due weight to architectural features as well as cytology. This paper proposes and illustrates updated criteria for scoring and grading melanocytic dysplasia, incorporating some of the definitions and categories of WHO-C, while refining the quantitative and …

Trial Interviews To Explore Glycogen Storage Disease Type Ia Patient Experiences Following Gene Therapy, Diane M Turner-Bowker, Jessica Butler, Shayna Egan, David A Weinstein, David F Rodriguez-Buritica, Ayesha Ahmad, María-Luz Couce, Rebecca Riba-Wolman, John J Mitchell, Christina Theodore-Oklota

Faculty, Staff and Student Publications

Background: Glycogen storage disease type Ia (GSDIa) is a rare, inherited, autosomal recessive deficiency of glucose-6-phosphatase (G6Pase), an enzyme necessary in glycogenolysis and gluconeogenesis. To maintain normal blood glucose levels and ensure survival, individuals living with GSDIa must frequently consume complex carbohydrates (eg, uncooked cornstarch). Dietary management can result in chronic complications and significant patient burden. DTX401 (pariglasgene brecaparvovec) is an investigational adeno-associated virus serotype 8 vector (AAV8)-based gene therapy designed to restore endogenous glucose production.

Objectives: Patient experience interviews were conducted as part of an open-label, phase 1/2 dose-escalation trial (NCT03517085) evaluating the safety and efficacy of …

Review Of 'The Royal Musical Association: Creating Scholars, Advancing Research' By Leanne Langley, Nuria Bonet

School of Art, Design and Architecture

No abstract provided.

The Impact Of Service Learning On Social Capital And Community Engagement, Jason R. Ross

Journal of Excellence in College Teaching and Learning

Social capital is important for individual and societal advancement. For individuals, social capital helps one advance in the organizational hierarchy but also flows to communities as these individuals are more likely to volunteer for non-profit organizations and pool their resources to advance societal causes. This paper argues that one overlooked mechanism for generating social capital is through service learning. Service learning benefits students not only academically, but professionally as it helps students connect with voluntary organizations, often composed of individuals of means. Students then integrate into the social networks of these influential members and potentially benefit from the resources they …

Retrieval Practice And Student-Centered Learning: Instructional Strategies For Engaging University Classrooms, Carla Williams, Angela Danley

Journal of Excellence in College Teaching and Learning

This paper examines how retrieval practice and student-centered learning—core principles of the Science of Learning—can transform university instruction. Grounded in the Scholarship of Teaching and Learning, the manuscript describes instructional strategies implemented in a redesigned teacher preparation course, including exit tickets, Frayer models, literature circles, choice boards, and collaborative teams. Each strategy operationalizes key learning mechanisms such as retrieval, feedback, reflection, and cognitive load reduction, shifting cognitive effort from instructor to learner. The findings highlight how retrieval-based, student-centered routines enhance engagement, retention, and transfer, offering adaptable approaches for faculty across higher education disciplines.

Enhancing Market Transparency Through Co-Creation Of Csr And Sustainability Ratings Between Firms, Rating Agencies And Customers, Christopher Agyapong Siaw

Plymouth Business School

No abstract provided.

All Life As Witness: Developing A Mode Of Investigation Into Political Disappearance In 1960s Venezuela Reframed By Skinner Releasing Technique And Indigenous Knowledge, Livia Daza-Paris

School of Art, Design and Architecture Theses

This practice-based research develops Ecologies of Poetic Forensics, an investigative mode for approaching political disappearance as a felt, ongoing condition that also reverberates across worlds beyond the human. Focused on my father's disappearance during Venezuela's 1960s revolutionary movement, the research follows relational dynamics within the personal, political, ecological ‘many worlds’ (Indígena Zapatistas 1996) shaped by state violence, including those of campesinos (land-based workers) in Cocorote, Lara State. The inquiry unfolds across Venezuela, Canada, and the United States, tracing territory that exceeds state borders.

The research brings the Skinner Releasing Technique, a movement practice oriented by poetic imagery and embodied …

The Persistent Shock Of The Old: Making The Case For The Responsive Development Of Artwork Deploying Historical Museological Display Techniques., Duncan Cameron

School of Art, Design and Architecture Theses

My sculpture work and thesis investigate the potential of historical museological practices—particularly Victorian and Edwardian display technologies—in contemporary art-making and sculptural practice. I ask three central questions: how can the collection and display of natural history materials be ethically defended in the present day; how might traditional exhibition orthodoxies be reconfigured to privilege the prosaic, domestic, and handmade over the novel and precious; and what role does the idiosyncratic and beautiful play in narrating material stories within an ethical, Anthropocene-aware framework?The study employs a practice-led methodology combining iterative art-making, critical reflection, and active fieldwork. Working from a studio in Somerset, …

Planetarity And Relation: Ecology As Method, Ashish Ghadiali

School of Art, Design and Architecture Theses

The List of Works submitted comprises research through film, text, exhibition, performance and policy engagement, developed during a three-year period from 2021 to 2024 in the site-specific location of Southwest England. This multi-modal and interdisciplinary practice is framed in response to the question of how art and cultural strategy can, in the contexts of climate breakdown and global racial inequity, be conceived of as agency for environmental justice. In this integrative summary, I present a theoretical framework where ecology, in response to conditions of environmental crisis, is understood not only as a subject of inquiry but also as method. In …

Feminism, Domestic Abuse And The Singer-Songwriter, Kathryn Ferguson

School of Art, Design and Architecture Theses

This project explores how feminism and domestic abuse can be articulatedthrough songwriting. Research in music therapy, sociology and popular musicincreasingly speaks to the value of songwriting as a tool for personal andcommunity empowerment, but there is space to actively use songwriting toexplore feminist issues independently of the traditional commercial context ofpopular music. Existing feminist music has been deemed as at its mostsuccessful when it is linked clearly to social change in our communities(Greene, 2017, p.8). Modern popular feminist songwriting has been criticised fornot going far enough in deconstructing systemic patterns of patriarchy (Tong,2024, p.9). Considering this, engaging with academic research …

The Development Of Collaborative Relationships Between Disaster Relief Ngos: Barriers And Solutions, Christopher Phillips

Plymouth Business School Theses

Collaborative responses amongst disaster relief NGOs can be more effective in delivering aid when compared with responses conducted individually. Collaboration enables the sharing of resources, expertise, personnel, and funding, resulting in more efficient aid distribution in the wake of natural disasters. However, current research highlights that it is often challenging for NGOs to establish and sustain collaborative relationships due to different barriers. The challenges these barriers cause have been explored in previous research, but limited attention has been given with respect to how these can be addressed. Additionally, there is a lack of understanding of the relationships between these barriers, …

Analysis Of Volatility Between Macroeconomic Variables And Busan Port Cargo Throughput According To Global Risks, Sang Ho Cho

Plymouth Business School Theses

This study investigates how container (BPC) and non-container (BPB) cargo throughput at Busan Port responds to structural shocks in global and domestic macroeconomic variables, and how their relative importance changes over time. The selection of variables was based on a combination of a Systematic Literature Review (SLR) and semi-structured interviews (SSI). The econometric analysis applied a stepwise framework, employing cumulative Impulse Response Functions (IRF) and Forecast Error Variance Decomposition (FEVD) based on Vector Error Correction Model (VECM) estimations, as well as Historical Decomposition (HD) for specific crisis periods. While IRF and FEVD were used to capture dynamic properties under general …

Driving Venture Success: A Collaborative Framework For The Consumer Goods Industry, Mohammad Alhusaeini Mohammad

Plymouth Business School Theses

This thesis addresses the persistent gap between the strategic promise of external corporate venturing (ECV) and its frequently disappointing outcomes in the global consumer goods industry, with a specific focus on the non-durable consumer goods sub‑sector. Despite ECV’s recognised importance for innovation—particularly in a sector characterised by rapid consumer preference shifts, tight margins, and complex supply chains—collaborations with external start-ups are often undermined by cultural misalignment, strategic ambiguity, and ineffective performance measurement. Through an abductive, mixed-methods research design within an interpretivist paradigm—integrating archival analysis, six in-depth corporate case studies (P&G, PepsiCo, Unilever, Danone, Henkel, and L’Oréal), and 32 interviews with …

Does In-Bed Cycling Delivered Within 48 Hours Of Mechanical Ventilation, Reduce The Occurrence Of Delirium In Critically Ill Patients: A Mixed-Methods Feasibility Randomised Controlled Trial Protocol, Jacqueline Bennion, Mark Hudson, Mary Hickson, Victoria Allgar, Bridie Kent, David Mcwilliams, Daniel Martin

Peninsula Medical School

Background: Delirium is a severe neuropsychiatric clinical state presenting as an acute onset of cognitive deficits. Patients receiving invasive mechanical ventilation (IMV), have the highest incidence (50%–80%) of delirium amongst patients admitted to intensive care units. Preliminary data indicates that early mobilisation is associated with reduced delirium in critically ill patients. However, definitive evidence is lacking. Current practice varies due to many barriers to patients, who require IMV, receiving early mobilisation interventions. In-bed cycling may address some of these barriers. This research aims to evaluate the feasibility and acceptability of early in-bed cycling to reduce delirium in critically ill patients. …

Patient And Practitioner Workshops For An Intellectual Disabilities And Epilepsy Neuropsychiatric Genetic Research Database Register: Ethical Dilemmas For Study Design, Rohit Shankar, Jon Allard, Dannielle Bilkey, Brendan Mclean, Pamela Bowman, Chloe Staples, Lance Watkins, Anna Simpson, Elizabeth Boardman, Sarah Mitchell, Sarah Lennard

Peninsula Medical School

BackgroundThere is a need for more research studies focussed on People with ID (PwID) and Epilepsy and for the design of these studies to be shaped by this complex and vulnerable population and those who care for and support them.AimsTo develop understanding as to how a future NHS genetic research database register for PwID and Epilepsy should be conducted in a way which is inclusive, suitable and appropriate for them, their carers and the NHS settings where the research would be undertaken.MethodsThree workshops were completed with 17 formal participants: (1) PwID and Epilepsy (n2); (2) carers of PwID and Epilepsy …

Psychotropic Medication Prescribing To Children And Young People Mental Health Inpatient Services: An English National Study, David Branford, Anne Webster, Marinos Kyriakopoulos, Shermin Imran, Prathiba Chitsabesan, Tina Irani, Teresa Randon, Kirsten Peebles, Rohit Shankar

Peninsula Medical School

Background:Mental disorders frequently begin in childhood or adolescence. Worldwide, psychotropics are commonly prescribed for under-18s to stabilise behaviour, mood or thoughts. Psychotropics could cause long-term effects on children and young people (CYP) health, growth and development. There is a knowledge gap about psychotropic prescribing in CYP mental health inpatient units.Aims:To understand and compare psychotropic prescribing patterns in England mental health inpatient units for CYPs and to solicit CYP and their parents’ and carers’ views of it.Method:A national Quality Improvement programme authorised by National Health Service (NHS) England invited all English CYP mental health inpatient units to participate. The programme included …

Measuring Outcomes In Evaluations Of Interventions To Prevent Youth Crime And Violence: Challenges And Potential Solutions, Sajid Humayun, Finlay Green, Helen Downham, Nick Axford

Peninsula Medical School

There is a clear imperative to prevent youth crime and violence owing to the significant social and economic costs for individuals involved and wider society. A considerable evidence base for ‘what works’ in this space exists but gaps remain. To address these, it is necessary to evaluate intervention effectiveness. The aim of this article is to explore challenges and potential solutions regarding outcome measurement in such evaluations. To do this we draw on the literature and our experience as evaluators. We argue that outcome selection should be informed by a robust theory of change, and that normally this will mean …

Small-Molecule Therapies Targeting Tumor-Associated Macrophages In Glioma: Mechanisms And Potential, Hua Wang, Heng Luo, Haijian Zhong, Amy Ockleton, Feng Jiang, Renhui Yi, Shaochun Yang, Ming Li

Peninsula Medical School

Glioblastoma, a highly prevalent and aggressive primary brain tumor, is marked by poor prognosis due to the blood-brain barrier and chemoresistance, which limit conventional pharmacotherapy. Recent research has pivoted toward targeting the tumor microenvironment, where tumor-associated macrophages (TAMs) drive gliomagenesis and malignant progression through immunosuppressive signaling. Small-molecule agents targeting TAMs have emerged as promising therapeutics, capable of reprogramming macrophage polarization, modulating immune cell dynamics, and suppressing glioma growth. This review explores the mechanistic roles of TAMs in glioma and evaluates how small-molecule compounds exert antitumor effects via TAM modulation. These insights lay a foundation for developing next-generation TAM-targeted therapies, offering …

Empowering State-Level Multilingual Education Leaders: Harnessing Generative Artificial Intelligence For Program Administration, Geqigula M. Dlamini

University of the Pacific Theses and Dissertations

This study aimed to understand how generative artificial intelligence could empower program staff at the California Department of Education (CDE) who support state-level multilingual programs by providing training and opportunities to review existing practices and identify promising use cases. With limited fiscal and personnel resources, state program staff had to rethink and intentionally consider how to enhance their own capacity to keep program momentum and support practitioners in the growth area of multilingual education.

With empowerment theory as the theoretical framework, this qualitative, participatory action research study involved 11 members of the Multilingual Support Division at the CDE. These co-researchers …

Examining Challenges For Sociology Master’S Degree Students At California State University, David Ortuno

University of the Pacific Theses and Dissertations

The purpose of this study is to identify the lived experiences of CSU sociology graduate students pursuing a master’s degree. Seven sociology graduate students from six of the eight (75%) total sociology MA programs throughout the entire CSU system were interviewed. Their responses were designed to analyze the support systems and challenges they face while pursuing a master's degree, as well as to investigate whether their experiences correlate with or fail to correlate with the promises in the CSU mission statement, and to answer the study’s research questions and achieve the purpose of this qualitative study.

Four themes emerged from …

Organizational Executives’ Perspectives On Cultural Humility And Diversity, Lynette Piggee-Pinero

University of the Pacific Theses and Dissertations

The purpose of this action-oriented dissertation was to understand how executives perceive their own cultural humility and how their perceptions impact diversity promotion in the workplace. This study used action research to examine the perspectives of executives on their own cultural humility and how cultural humility promotes diversity. This study included data collected from interviews with eight executives. Findings from the study revealed that executives perceived their own cultural humility as evident in a commitment to learning about others, their ability to suspend their own biases, and their commitment to ongoing learning. The findings were also that executives expressed connections …

Coaching-Based Leadership Communication In Higher Education Hybrid Work Environments, Lisa Erck

University of the Pacific Theses and Dissertations

This study examined how coaching-based leadership (CBL) communication practices were associated with participants’ perceptions of communication, collaboration, and engagement within a hybrid higher education work environment. Grounded in constructivist leadership theory (CLT), CBL, and action research (AR), the study explored how intentional shifts in leader communication behaviors influenced team interactions over time. Using a qualitative AR design, I partnered with a higher education administrative leader and their team in a hybrid setting. The participant group included the leader and their direct reports. Data were collected across iterative AR cycles through semistructured interviews, observational data, and participant reflection journals. Data analysis …

Empowering Equity: Latinas In Leadership – Navigating Work-Life Balance In The Post-Pandemic Era, Teresa Excinia

University of the Pacific Theses and Dissertations

This dissertation explored the lived experiences of Latina leaders as they navigated how cultural expectations influenced work–life balance in the post-pandemic era. The COVID-19 pandemic reshaped workplace dynamics, blurring boundaries between professional responsibilities and personal life. For Latinas, these challenges were compounded by cultural expectations that shaped their roles both at home and in the workplace. The purpose of this study was to understand how Latina leaders managed the dual pressures of balancing career demands with cultural and familial obligations. Using Testimonio as the methodological framework, this study captured the voices and narratives of Latina leaders across industries, offering an …

Identifying Barriers To Black Student Participation In The Advanced Placement Program, Juan Ramon Jauregui Jr.

University of the Pacific Theses and Dissertations

This qualitative study explored the factors that encouraged or deterred students from enrolling in Advanced Placement (AP) courses during high school. Grounded in Critical Race Theory, the research reviewed how school systems, relationships with peers and adults, and individual student factors influenced the participants in this study. The researcher utilized semistructured interviews with seven Black students who were currently enrolled in college and had recently graduated high school, and identified the factors that influenced their decision-making process in enrolling in AP courses. Using a thematic analysis approach, data was organized, coded, and then the researcher identified multiple themes emerging from …

The Giant Antarctic Amphipod Paraceradocus Miersi Will Not Fare Well If Freshening Continues In The Southern Ocean, John I. Spicer, Simon A. Morley, Katie N.G. Thiessen, Lloyd S. Peck

School of Biological and Marine Sciences

Sea water provides a stable environment for marine animals. Most oceanic invertebrates have body fluids similar in ionic composition to sea water. However, Antarctic coastal ecosystems are increasingly exposed to freshening—a reduction in salinity driven by glacial melt, increased precipitation, and extreme weather events. Such changes can cause mortality in Antarctic invertebrates, which generally are intolerant to reduced salinity. This study investigated osmotic and ionic regulation of the Antarctic amphipod Paraceradocus miersi exposed to simulated freshening. When salinity was reduced (from S = 34.6 to 28.0) for 12–48 h, haemolymph osmolality and sodium concentration declined, while calcium remained stable; magnesium …

Video Interaction Guidance With Adults With Intellectual Disabilities And Their Support Workers: A Service Evaluation, Áine Maguire, Vicky Anagnostopoulou, Joe Levi-French, Deanna J. Gallichan

School of Psychology

Background: This service evaluation focused on support workers' perceptions of Video Interaction Guidance (VIG) offered by an NHS Community Learning Disabilities Team. Methods: A mixed-methods design was employed. Support workers developed goals and rated their progress before and after VIG sessions. Thematic analysis was used to analyse qualitative data on the nature of the goals developed, and the strengths and working points identified. The differences between progress ratings before and after VIG were analysed using the Wilcoxon signed-rank test. Retrospective interviews helped to further understand support workers' experiences of VIG. Findings: Support workers identified goals, strengths and working points that …

Same Interdependent Risk, Different Valuation: How Risk Representation Shapes Ecosystem Investment Decisions, Shiyao Bao, Jiamin Zhao, En Yang, Llewellyn D. W. Thomas, Hansjörg Neth, Jan K. Woike, Sebastian Hafenbrädl

School of Psychology

Why do decision makers value the same risky opportunity differently when the underlying probability of success is unchanged? We study this question in ecosystem investment decisions, where success requires that none of the critical components fail, causing component risks to compound. We conducted a high-powered preregistered replication and extension of Adner and Feiler's key study (N = 3,600). Participants valued a $100,000 opportunity that required six independent components to succeed, each with a 75% chance of success, yielding an overall success probability of ≈18%. Replicating prior work, participants reported higher confidence and assigned higher valuations when they first saw the …

The Permanent Bar(S): The Unprincipled Cage Of Retribution For Immigrant Youth, Dianara Ramirez Ibarra

Cardozo Law Review

This Note argues that a minor’s diminished decisional capacity should be recognized as an affirmative defense when a permanent bar that is triggered during minority strips away a noncitizen’s opportunity to gain lawful status in the United States. Dreamers and Deferred Action for Childhood Arrivals (DACA) recipients, individuals who arrived in the United States as children, are victims of punitive immigration laws that have extinguished any possibility of securing lawful residency in the United States. Even more egregiously, Dreamers and DACA recipients are subject to these permanent bars despite lacking the intent and capacity to fully understand the long-term consequences …

Multihoming And Single-Homing Complementors' Responses To Intensified Between-Platform Competition: Evidence From The Youtube–Twitch Rivalry, Niloofar Abolfathi

Research Collection Lee Kong Chian School Of Business

Research Summary: This paper examines how heterogeneous YouTube content creators-specifically, single-homing and multihoming channels-respond to a sudden increase in the exposure of the rival platform, Twitch. Contrary to expectations, I find that multihoming channels reduce their content creation efforts and underperform relative to single-homers. To make sense of these surprising results, I develop a formal model that characterizes the strategic behavior of different types of complementors operating across two platforms with varying levels of user exposure. The model offers a plausible explanation for the observed empirical patterns, suggesting that intensified competition between platforms, as a consequence of their changing exposure, …