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Experimental Investigation And Optimization Of Process Parameters Affecting The Compressive And Flexural Strength Of Epoxy Concrete For Machine Tool Structure By Using Taguchi Method, Amitkumar C Gohil, Hardik G. Chothani Jan 2026

Experimental Investigation And Optimization Of Process Parameters Affecting The Compressive And Flexural Strength Of Epoxy Concrete For Machine Tool Structure By Using Taguchi Method, Amitkumar C Gohil, Hardik G. Chothani

Mansoura Engineering Journal

The structural performance of machine tool is strongly influenced by rigidity and damping characteristic; however, conventional material such as grey cast iron and steel exhibits limitation in achieving an optimal balance between weight, strength and vibration damping. The necessitates the development of alternative material with improved performance. In this study epoxy concrete is investigated as a potential material for machine tool structure, focusing on its compressive strength and flexural strength. A systematic experimental approach based on Taguchi method (L25 orthogonal array) was employed to optimize key process parameter, including resin contain, aggregate size, sand proportion, shaking time and curing duration. …


Kekuasaan Yudisial Dalam Sistem Demokrasi Konstitusional: Membangun Antitesis Dekonstitusionalisasi Dan Politisasi Peradilan, Tundjung Herning Sitabuana, Airlangga Surya Nagara, Dixon Sanjaya Jan 2026

Kekuasaan Yudisial Dalam Sistem Demokrasi Konstitusional: Membangun Antitesis Dekonstitusionalisasi Dan Politisasi Peradilan, Tundjung Herning Sitabuana, Airlangga Surya Nagara, Dixon Sanjaya

Jurnal Hukum & Pembangunan

Strengthening idea of constitutional democracy as a transitional phase towards a modern rule of law requires one of main characteristics of an independent judiciary. Current phenomena demonstrate how utopian these conditions are as the judiciary becomes increasingly politically pragmatic, transactional, interdependent, and demoralized. At the same time, phenomenon of constitutional defiance is growing stronger with efforts to deconstitutionalize and politicize the judiciary. This study aims to explore the existence and legitimacy of the judiciary in constitutional democracy era against that phenomenon. The research was conducted doctrinally with a historical, conceptual, and comparative approach that was analyzed qualitatively. The results indicate …


Magang Atau Pekerja? Menggugat Status Abu-Abu Tenaga Paruh Waktu Mahasiswa Di Fakultas Hukum Ugm, Patricia Nerissa Krisna Putri, Markus Togar Wijaya Jan 2026

Magang Atau Pekerja? Menggugat Status Abu-Abu Tenaga Paruh Waktu Mahasiswa Di Fakultas Hukum Ugm, Patricia Nerissa Krisna Putri, Markus Togar Wijaya

Jurnal Hukum & Pembangunan

This study highlights the controversy surrounding the change in nomenclature for student workers at Gadjah Mada University, particularly within the Faculty of Law. The status of these workers has shifted from 'part-time' to 'student intern'. This unilateral change has created a legal grey area that could lead to students being subjected to disguised employment practices. Using socio-legal research methods, this article examines the validity of the 'internship' status based on the elements of an employment relationship (work, orders and wages) within the labour law regime, analysing it using the theory of structural injustice. The research findings suggest that reclassifying part-time …


Omnibus Law Sebagai Strategi Mengatasi Disharmonisasi Peraturan Di Indonesia, Tuti Tri Hastuti S., Zainal Arifin Hoessein Jan 2026

Omnibus Law Sebagai Strategi Mengatasi Disharmonisasi Peraturan Di Indonesia, Tuti Tri Hastuti S., Zainal Arifin Hoessein

Jurnal Hukum & Pembangunan

This article discusses the challenges in implementing the Omnibus Law (OL) both as a regulatory system and as a tool for harmonizing regulations within Indonesia’s legal positivist tradition and its complex, non-simple regulatory hierarchy, from the perspectives of legislative consolidation theory, regulatory coherence theory, and multilevel regulation theory. This study is based on the assumption that OL, within the framework of legal positivism (norm hierarchy system), faces problems in applying these three theories. The research employs normative juridical and comparative methods, analyzing national regulations and international research findings. The results indicate, first, that the positioning of OL, which does not …


Pertanggungjawaban Perusahaan Pengangkut Pada Tindakan General Average Terhadap Kerugian Kargo Yang Diangkut, Sandra A. M. Lova, Zahry Vandawati Chumaida Jan 2026

Pertanggungjawaban Perusahaan Pengangkut Pada Tindakan General Average Terhadap Kerugian Kargo Yang Diangkut, Sandra A. M. Lova, Zahry Vandawati Chumaida

Jurnal Hukum & Pembangunan

Maritime transportation plays a vital role in supporting trade, yet risks such as perils of the sea or ship accidents caused by unseaworthiness often lead to disputes, particularly when General Average is declared. This practice, recognized since Roman times, has evolved into a legal concept in marine insurance to distribute deliberate sacrifices made for the safety of the vessel and its cargo. This study aims to analyze the liability of carriers in General Average actions and to evaluate the concept as a fair mechanism for loss distribution. The research employs a normative juridical method with statutory, conceptual, and comparative approaches, …


Opioid Abuse: Community Education, Meggan N. Wolff-Jackson Jan 2026

Opioid Abuse: Community Education, Meggan N. Wolff-Jackson

Doctor of Nursing Practice Projects

The opioid epidemic in the United States has persisted for over two decades and has become one of the leading causes of accidental deaths nationwide (Robert et al., 2022). The opioid crisis represents a widespread public health emergency that extends beyond individual and community boundaries, imposing burdens on both the national economy and the healthcare system (Kyei et al., 2024). Although the opioid epidemic is a global concern, it is particularly concerning in the target community located in the western part of North Carolina. This region has some of the highest rates of opioid overdoses within the state, with 118 …


The Essentials Of Heart Failure Management, Emily W. Greene Jan 2026

The Essentials Of Heart Failure Management, Emily W. Greene

Doctor of Nursing Practice Projects

Heart failure remains a leading cause of hospitalization among older adult women, often due to delayed recognition of symptom exacerbation and limited knowledge of self-management strategies. The purpose of this quality improvement project was to evaluate whether a brief educational intervention could improve knowledge of heart failure management among older adult women at a community senior center. The DNP project leader conducted two educational sessions focusing on early recognition of heart failure symptoms, heart-healthy diet, and when to contact a healthcare provider. Participants completed a pre- and post-test survey containing four knowledge questions and one Likert-scale question on perceived knowledge …


Integrating Lactation Education Into Centering Pregnancy To Enhance Maternal Confidence And Lactation Initiation Rates, Courtney Barbee Jan 2026

Integrating Lactation Education Into Centering Pregnancy To Enhance Maternal Confidence And Lactation Initiation Rates, Courtney Barbee

Doctor of Nursing Practice Projects

Introduction: Breastfeeding remains the gold standard for infant nutrition providing physical and psychological benefits for both mother and baby. The inadequacy of lactation education and support continue to hinder breastfeeding initiation in the rural areas of North Carolina. Integrating a board-certified lactation consultant into the Centering Pregnancy model provides an evidence-based strategy to improve maternal confidence and increase lactation initiation rates within the target community.

Method: Using a quality improvement framework, the project targeted expecting mothers participating in Centering Pregnancy. Pre- and post-surveys assessed confidence levels after receiving two educational sessions with a board-certified lactation consultant.

Results: …


Musical Measures: Nurse Education On Music-Based Interventions To Reduce Patient Restraints, Crystal D. Tucker Jan 2026

Musical Measures: Nurse Education On Music-Based Interventions To Reduce Patient Restraints, Crystal D. Tucker

Doctor of Nursing Practice Projects

The use of physical restraints in acute psychiatric settings poses significant risks to patient safety, including physical injury and psychological distress. Evidence supports the need for alternative, non-pharmacologic interventions to reduce reliance on restraints. This Doctor of Nursing Practice quality improvement project aimed to evaluate the impact of an educational intervention on nurses’ knowledge and confidence in implementing music-based interventions, specifically binaural beats, to manage patient anxiety and agitation.

The project was conducted on a medical observation and behavioral health holding unit and utilized a pre- and post-intervention design. Registered nurses participated in educational sessions on music-based interventions and were …


Diabetes Education In Buncombe County, Deonna Nicole Blount Jan 2026

Diabetes Education In Buncombe County, Deonna Nicole Blount

Doctor of Nursing Practice Projects

The growing number of Americans living with diabetes has reached an all-time high. According to the Centers for Disease Control and Prevention (CDC) (2026), there are 40.1 million people diagnosed with or underdiagnosed with diabetes. Evidence has shown that with education tailored to the patient's lifestyle, changes can be made and healthier lifestyles exhibited. Understanding the why of the patients can assist in changes that are feasible and can be implemented for the now and the future. Several studies outlined by Alonso-Carril et al. (2024), Lander et al. (2022), and Hodges et al. (2019) showed that education was implemented and …


Improving Overall Morale Of Nurses By Implementing A Serenity Room, Ruth B. Clarke-Johnson Jan 2026

Improving Overall Morale Of Nurses By Implementing A Serenity Room, Ruth B. Clarke-Johnson

Doctor of Nursing Practice Projects

Nursing, while a highly respected profession grounded in research and scientific practice, continues to face persistent challenges related to staff retention and morale. Key contributors include burnout related to high workloads, challenging staffing ratios, lack of supportive leadership, and an aging workforce. Together, these factors hinder healthcare organizations’ ability to sustain a stable and experienced staff. The implementation of a serenity or relaxation room is supported by growing evidence highlighting its positive effects on nurse morale and stress reduction. A review by Mileski et al. (2022) found wellness spaces significantly reduced burnout, emotional exhaustion, and stress while improving resilience, job …


Spreading Awareness To Adults About Cardiovascular Disease And Improving Healthy Lifestyle Habits, Madison L. Eldridge Jan 2026

Spreading Awareness To Adults About Cardiovascular Disease And Improving Healthy Lifestyle Habits, Madison L. Eldridge

Doctor of Nursing Practice Projects

Introduction: The intention of this Doctor of Nursing Practice evidence-based project was to evaluate if providing education to the target community would increase awareness and knowledge of cardiovascular disease and healthy lifestyle habits. The goal was to increase educational knowledge and promote awareness of cardiovascular disease and healthy lifestyle habits.

Background: Cardiovascular disease (CVD) is a critical health issue that prevails across the state of North Carolina, while continuing to remain one of the leading causes of death across the south-center Piedmont area of North Carolina. Several studies have proven that increasing knowledge on cardiovascular risks, promoting healthy exercise, and …


Senior Heart Health Facilitating Hypertension Management, Heather Hodgens Lupo Jan 2026

Senior Heart Health Facilitating Hypertension Management, Heather Hodgens Lupo

Doctor of Nursing Practice Projects

Hypertension affects approximately 70% of adults aged 65 years and older and remains a leading contributor to cardiovascular morbidity and mortality in the United States, highlighting the need for effective community-based hypertension management interventions. Despite the availability of evidence-based guidelines, gaps in education and self-management persist among older adults. This Doctor of Nursing Practice (DNP) quality improvement project, Senior Heart Health: Facilitating Hypertension Management, was designed to improve hypertension-related knowledge among adults aged 55 years and older through a structured, community-based health coaching intervention.

The project was implemented in a rural community and consisted of four weekly educational sessions delivered …


Enhancing Mass Casualty Incident Preparedness: Bridging The Gap Between Education And Practice, Emily M. Coggins Jan 2026

Enhancing Mass Casualty Incident Preparedness: Bridging The Gap Between Education And Practice, Emily M. Coggins

Doctor of Nursing Practice Projects

The increasing amount of mass casualty incidents (MCIs), such as natural disasters, large-scale emergencies, and active shooter events, has emphasized the need for healthcare professionals to respond effectively. Traditional undergraduate nursing curriculum often offers limited opportunities for students to practice disaster preparedness through simulated experiences. This DNP project was created to evaluate the effectiveness of implementing an MCI training simulation to increase the confidence and competence of senior pre-licensure nursing students when responding to a mass casualty event. The project implemented a 1-day, simulation-based MCI event for senior nursing students enrolled in an Adult Health II course. The event included …


Enhancing Clinical Judgement In Pre-Licensure Nursing Students Through Active Learning Strategies Of Unfolding Case Studies And Simulations For Postpartum Hemorrhage, Lisa M. Alley Jan 2026

Enhancing Clinical Judgement In Pre-Licensure Nursing Students Through Active Learning Strategies Of Unfolding Case Studies And Simulations For Postpartum Hemorrhage, Lisa M. Alley

Doctor of Nursing Practice Projects

New graduate nurses lack the appropriate clinical judgement to provide optimal, safe, quality care, as evidenced by the report of errors in health care (Rodziewicz et al., 2024). The purpose of this project was to provide an evidence-based intervention that used an unfolding case study and simulation to further develop clinical judgement among undergraduate nursing students in a rural ADN program. The project used a pre-test and post-test to measure students' improvement prior to versus after the learning experience and debrief. This project also introduced a DASH tool, which is a debriefing assessment for simulations in healthcare, to help students …


Judge Me Not: Exploring Black Mothers’ Perceptions Of Maternal Health Care Services And Structural Racism In South Carolina, Julisa Tindall, Teri Browne Ph.D., Msw, Tisha M. Felder Phd, Msw, Bongki Woo Ph.D., Bree Alexander-Richardson Jan 2026

Judge Me Not: Exploring Black Mothers’ Perceptions Of Maternal Health Care Services And Structural Racism In South Carolina, Julisa Tindall, Teri Browne Ph.D., Msw, Tisha M. Felder Phd, Msw, Bongki Woo Ph.D., Bree Alexander-Richardson

Publications

Black women in the United States face disproportionately high rates of maternal mortality, driven by structural racism, patient-provider mistreatment, and gendered and racial discrimination. However, little research has explored Black mothers’ perceptions of maternal health care services and structural racism in the Southeastern U.S. This study aims to address this gap by examining Black mothers’ maternal health care experiences in South Carolina. Using semi-structured interviews conducted during the summer of 2023 with Black mothers who had given birth within the previous five years, this qualitative study employed grounded theory to analyze recurring themes in their maternal health care experiences. The …


Super-Efficient Breach In Bankruptcy: Recalibrating Remedies For Contract Rejection Damages, Ishaq Kundawala Jan 2026

Super-Efficient Breach In Bankruptcy: Recalibrating Remedies For Contract Rejection Damages, Ishaq Kundawala

Emory Bankruptcy Developments Journal

Contract law rests on a simple but powerful premise: when a party breaches, the law protects the injured party’s expectation interest, placing them, as nearly as possible, in the position they would have occupied had the contract been performed. This principle underlies the theory of efficient breach, which tolerates economically rational breaches so long as the non-breaching party is fully compensated. But in bankruptcy, this foundation often collapses. Under section 365 of the Bankruptcy Code, a debtor may reject an executory contract, with the law treating that rejection as a prepetition breach and relegating the counterparty’s claim to general unsecured …


Early Clinical Outcomes Of The Use Of Del Nido Versus Intermittent Warm Blood Cardioplegia After Isolated Coronary Artery Bypass Surgery, Ahmed Abdalla Mohamed, Ahmed M Elshemy, Sherif M Elboghdady, Wael S Nekhila, Ismail R Barrada Jan 2026

Early Clinical Outcomes Of The Use Of Del Nido Versus Intermittent Warm Blood Cardioplegia After Isolated Coronary Artery Bypass Surgery, Ahmed Abdalla Mohamed, Ahmed M Elshemy, Sherif M Elboghdady, Wael S Nekhila, Ismail R Barrada

Journal of Medicine in Scientific Research

Background While the best approach to protecting the heart during surgery varies based on the specific operation and the surgeon's preferences, del Nido cardioplegia, initially successful in children, is gaining traction as an alternative to the traditional blood cardioplegia in adult cardiac procedures. Aim This investigation comparatively analysed the early postoperative consequences in adult patients undergoing isolated coronary artery bypass grafting, contrasting the application of del Nido cardioplegia with conventional warm blood cardioplegia techniques. Methods Randomised controlled clinical research was conducted to compare the efficacy of antegrade del Nido (DNC) and intermittent warm blood cardioplegia (IWBC) in safeguarding myocardial function …


Infimum Dimension Nash Embeddings For 2d Projective Shape Analysis, Robert L. Paige, Vic Patrangenaru Jan 2026

Infimum Dimension Nash Embeddings For 2d Projective Shape Analysis, Robert L. Paige, Vic Patrangenaru

Mathematics and Statistics Faculty Research & Creative Works

Vector embeddings make complicated data extracted from networks, words and images, more amendable to data science applications. At the present time, the Veronese-Whitney (VW) matrix embedding of the real projective space is the state of the art for making inference about digital images from an uncalibrated camera, such as a cell phone or security camera. In this work we consider vector embeddings for the projective shape data and in particular determine the minimum dimension isometric (distance-preserving or Nash) vector embedding for a projective space. We determine such an embedding for the projective plane in closed-form. From this embedding we determine …


A Fully Discrete Semi-Implicit Numerical Scheme And Its Optimal Error Estimates For Cahn-Hilliard-Mhd Model With Variable Density, Dongmei Duan, Fuzheng Gao, Xiaoming He, Yanping Lin Jan 2026

A Fully Discrete Semi-Implicit Numerical Scheme And Its Optimal Error Estimates For Cahn-Hilliard-Mhd Model With Variable Density, Dongmei Duan, Fuzheng Gao, Xiaoming He, Yanping Lin

Mathematics and Statistics Faculty Research & Creative Works

This paper proposes and analyzes a fully discrete semi-implicit unconditionally energy stable numerical scheme to solve the Cahn-Hilliard Magnetohydrodynamics (Cahn-Hilliard-MHD) model with variable density. The unconditional energy stability and optimal L2 error estimates are established for the fully discrete scheme. Major challenges in error estimation arise from the variable density, the strong nonlinearities, and the multi-physics coupling of the model. Under the mathematical induction framework, the Ritz quasi-projection and the Stokes quasi-projection, proposed in [SIAM J. Numer. Anal., 61(3):1218-1245, 2023], are utilized to avoid the gradient terms of the projection errors. The H−1 superconvergence error estimates of Ritz …


Insurance And Chapter 11 Bankruptcy: Is The Insurance Neutrality Doctrine Dead?, Mikaela Deleon Jan 2026

Insurance And Chapter 11 Bankruptcy: Is The Insurance Neutrality Doctrine Dead?, Mikaela Deleon

Emory Bankruptcy Developments Journal

Insurers have traditionally been denied “party in interest” status under the Bankruptcy Code due to the longstanding insurance neutrality doctrine. The insurance neutrality doctrine prevents insurers from challenging a chapter 11 bankruptcy plan as a section 1109(b) “party in interest” if the plan does not increase the insurance company’s liability from pre-bankruptcy levels. If none of their rights or obligations were impacted by the plan, insurance companies were previously left without a means to challenge a proposed reorganization plan. As a result, insurance companies providing liability insurance to corporations stricken with mass tort lawsuits ran the risk of becoming the …


Asbestos 2.0: A Looming Disaster At The Intersection Of Pfas Litigation And The Texas Two-Step––Even After Purdue Pharma, Tyler Sheridan Jan 2026

Asbestos 2.0: A Looming Disaster At The Intersection Of Pfas Litigation And The Texas Two-Step––Even After Purdue Pharma, Tyler Sheridan

Emory Bankruptcy Developments Journal

Companies that have manufactured, processed, or sold per- and polyfluoroalkyl substances (“PFAS”), also known as “forever chemicals,” face mounting financial pressure as the number of claims against them skyrocket. With billions of dollars already allocated to settlements and new lawsuits continuously filed, liable corporations may utilize the Texas Two-Step to minimize financial risk. The maneuver would enable solvent companies to isolate PFAS liability and discard it into bankruptcy, potentially delaying and capping payouts for claimants in the process. Third-party releases have survived Purdue, leaving the forum’s ability to permanently resolve mass tort liability intact. Moreover, escalating litigation may prompt …


Made On Mars: Design And Manufacturing Of Structural Polymer-Regolith Composites, Pailey M. Vitale Jan 2026

Made On Mars: Design And Manufacturing Of Structural Polymer-Regolith Composites, Pailey M. Vitale

Williams Honors College, Honors Research Projects

Human exploration of Mars is constrained by harsh environmental conditions and the prohibitive cost of transporting materials from Earth. Long-term sustainability requires the local production of mechanical and structural components using resources available on Mars, thereby minimizing payload mass. This project investigates polymer–regolith composites derived from atmospheric CO₂ and mineral-rich regolith as a pathway toward in-situ manufacturing. These composites, when compatible with additive manufacturing, could replace imported plastics, enable on-demand fabrication, and support closed-loop recycling systems. The objective is to design and evaluate polymer–regolith composites that maintain mechanical integrity and environmental resistance under Martian conditions, including extreme temperature swings, radiation …


Akron Police Department Non-Fatal Shootings, Sarah B. Baumer Jan 2026

Akron Police Department Non-Fatal Shootings, Sarah B. Baumer

Williams Honors College, Honors Research Projects

This project will study the variables that impact disposition status of non-fatal shooting cases in the city of Akron. This research project will be conducted through temporal and spatial analysis of the information gathered from the Akron Police Department. This analysis will identify common factors and patterns throughout the non-fatal shooting cases. This will then follow with in depth research of intelligence led policing articles that provide relevant solutions. The final steps will be identifying and adapting solutions to fit the needs of the Akron Police Department. The final product will include maps, police products and data visualization through Excel.


The Impact Of Congenital Heart Disease On The Timing Of Alzheimer's Disease In Down Syndrome, Julianne G. Clina, Brian C. Helsel, Sigan L. Hartley, David A. White, Victoria L. Fleming-Batayneh, Benjamin Handen, Bradley Christian, Elizabeth Head, Mark Mapstone, Christy L. Hom, Beau Ances, Jeffrey Burns, H. Diana Rosas, Florence Lai, Sharon Krinsky Mchale, Joseph H. Lee, Frederick A. Schmitt, Jordan Harp, Ira T. Lott, Shahid Zaman, Lauren T. Ptomey Jan 2026

The Impact Of Congenital Heart Disease On The Timing Of Alzheimer's Disease In Down Syndrome, Julianne G. Clina, Brian C. Helsel, Sigan L. Hartley, David A. White, Victoria L. Fleming-Batayneh, Benjamin Handen, Bradley Christian, Elizabeth Head, Mark Mapstone, Christy L. Hom, Beau Ances, Jeffrey Burns, H. Diana Rosas, Florence Lai, Sharon Krinsky Mchale, Joseph H. Lee, Frederick A. Schmitt, Jordan Harp, Ira T. Lott, Shahid Zaman, Lauren T. Ptomey

Neurology Faculty Publications

INTRODUCTION: The incidence of Alzheimer's disease (AD) in Down syndrome (DS) exceeds 90%. Approximately 50% of people with DS have congenital heart disease (CHD). Having CHD increases risk for early-onset AD in populations without DS, but it is unclear if CHD influences AD in DS. METHODS: Data from the Alzheimer Biomarker Consortium-Down Syndrome (ABC-DS) were used. Participants with CHD (n = 82, mean age = 39.9 ± 8.5 years, 97.6% White race) were age- and sex-matched to participants without CHD (n = 82, mean age = 40.5 ± 8.1 years, 98.8% White race). Cognitive assessments and Centiloid load (CL) (positron …


Plasma P-Tau217 And Apoe Genotype, Ann M. Stowe, Bilal Kahn, Ali Ballesteros, Monique Cortez, Linda S. Hynan, Victoria Cantrell, Indu Raman, Guangchun Chen, Eric D. Vidoni, Ellen Binder, Jeffrey Burns, Jeffrey N. Keller, Diana R. Kerwin, Tristyn Hall, Pavel Yanev, Wanpen Vongapatanasin, David C. Zhu, Norman Scheel, C. Munro Cullum, Rong Zhang, Dwight C. German Jan 2026

Plasma P-Tau217 And Apoe Genotype, Ann M. Stowe, Bilal Kahn, Ali Ballesteros, Monique Cortez, Linda S. Hynan, Victoria Cantrell, Indu Raman, Guangchun Chen, Eric D. Vidoni, Ellen Binder, Jeffrey Burns, Jeffrey N. Keller, Diana R. Kerwin, Tristyn Hall, Pavel Yanev, Wanpen Vongapatanasin, David C. Zhu, Norman Scheel, C. Munro Cullum, Rong Zhang, Dwight C. German

Neurology Faculty Publications

Introduction: Plasma phosphorylated tau (p-tau)217 levels and apolipoprotein E (APOE) ε4 genotype are used for prodromal identification of individuals at high risk for dementia. We used baseline samples from cognitively normal subjects in the Risk Reduction for Alzheimer's Disease (rrAD) clinical trial (NCT02913664) to investigate the relationship between these two markers in older adults with additional vascular risk factors. Methods: We measured APOE genotype, plasma p-tau217, and standard neuroimaging metrics in 400 rrAD participants, aged 60 to 84 years, with sedentary lifestyle, hypertension, and hypercholesterolemia. Results: Plasma p-tau217 was 57% higher in subjects with at least one APOE ε4 allele, …


Decoding The Human Pbmc Isonome, Patricia Hayes Doyle, Madeline L. Page, J. Anthony Brandon, Bernardo Aguzzoli Heberle, Brendan J. White, Ann Marie Stowe, Mark T.W. Ebbert Jan 2026

Decoding The Human Pbmc Isonome, Patricia Hayes Doyle, Madeline L. Page, J. Anthony Brandon, Bernardo Aguzzoli Heberle, Brendan J. White, Ann Marie Stowe, Mark T.W. Ebbert

Neurology Faculty Publications

Long-read single-cell RNA sequencing provides an opportunity to understand human health and disease at a level difficult to resolve with bulk or short-read methods. This approach enables isoform-level investigation of cellular diversity and disease mechanisms and definition of cell-types, rather than using genes alone. Using a modified, microfluidic-free PIPseq workflow and computational pipeline adapted for Oxford Nanopore long-read sequencing, we generated the largest long-read single-cell dataset of human peripheral blood mononuclear cells (PBMCs) from a single donor to date, the first with sufficient cell numbers to detect megakaryocytes. This study profiled isoform usage across immune cells, integrating marker expression and …


Post-Approval Study 3-Year Outcomes Of The Neuroform Atlas Stent For The Treatment Of Wide-Necked Intracranial Aneurysms, Brian Jankowitz, Ashutosh P. Jadhav, Bradley Gross, Tudor G. Jovin, Abdulnasser A. Alhajeri, Justin F. Fraser, Ricardo A. Hanel, Eric Sauvageau, Amin Aghaebrahim, Donald Frei, Richard Bellon, David N. Loy, Ajit S. Puri, Adel M. Malek, Ajith J. Thomas, Gabor Toth, Demetrius Klee Lopes, R. Webster Crowley, John Reavey-Cantwell, Eugene Lin, Adnan Siddiqui, Michael J. Alexander, Ahmad Khaldi, Geoffrey P. Colby, Justin M. Caplan, Sudhakar R. Satti, Aquilla S. Turk, Alejandro M. Spiotta, Richard Klucznik, Danial K. Hallam, David Kung, Michael T. Froehler Jan 2026

Post-Approval Study 3-Year Outcomes Of The Neuroform Atlas Stent For The Treatment Of Wide-Necked Intracranial Aneurysms, Brian Jankowitz, Ashutosh P. Jadhav, Bradley Gross, Tudor G. Jovin, Abdulnasser A. Alhajeri, Justin F. Fraser, Ricardo A. Hanel, Eric Sauvageau, Amin Aghaebrahim, Donald Frei, Richard Bellon, David N. Loy, Ajit S. Puri, Adel M. Malek, Ajith J. Thomas, Gabor Toth, Demetrius Klee Lopes, R. Webster Crowley, John Reavey-Cantwell, Eugene Lin, Adnan Siddiqui, Michael J. Alexander, Ahmad Khaldi, Geoffrey P. Colby, Justin M. Caplan, Sudhakar R. Satti, Aquilla S. Turk, Alejandro M. Spiotta, Richard Klucznik, Danial K. Hallam, David Kung, Michael T. Froehler

Neurology Faculty Publications

Introduction The ATLAS trial was a prospective, multicenter, single-arm, investigational device exemption (IDE) study to evaluate the safety and effectiveness of the Neuroform Atlas Stent System for the treatment of widenecked bifurcation aneurysms. This analysis presents the 36-month follow-up data for the anterior and posterior cohorts. Methods Of the 182patients in the IDE anterior cohort, 146 consented to participate in the post-approval study (PAS) and, of the 116patients in the IDE posterior cohort, 101 consented to participate in the PAS. The primary effectiveness endpoint was core laboratory adjudicated (Raymond–Roy 1; RR1) without retreatment or parent artery stenosis (>50%) at …


Microscopic Insights On Shear Rheology Of Polyampholyte Ionomers Via Molecular Simulations, Kyle Vonscio Jan 2026

Microscopic Insights On Shear Rheology Of Polyampholyte Ionomers Via Molecular Simulations, Kyle Vonscio

Williams Honors College, Honors Research Projects

Ionomers are polymers that contain a small fraction of charged groups. The ionic attraction of charged groups allows ionomers to act similarly to crosslinked polymers. Depending on the strength of electrostatic interactions and structure of the ionomers, different dynamics and rheological responses can be observed. With moderate attraction between ions, these noncovalent crosslinks can be broken when heated, allowing ionomers to flow and show the strength of a crosslinked network at low temperatures. Nonequilibrium molecular dynamics (NEMD) simulations will be performed under shear in the xy-plane and the macroscopic rheology and conformation of the polyampholyte ionomer will be determined. The …


Women's Work And Wealth: Measuring The Impact Of Incremental Liberations, 1850-1870, Hannah Kelly Jan 2026

Women's Work And Wealth: Measuring The Impact Of Incremental Liberations, 1850-1870, Hannah Kelly

Williams Honors College, Honors Research Projects

Using a two-way fixed effects difference-in-difference model, this project analyzes data from the IPUMS Full Count census for 1850, 1860, and 1870 at a state level for 48 states. Four models assess the impact of property laws on women's real property holdings, labor force participation, household types, and real property values.

By quantifying the impact of various legal reforms on women's economic empowerment, this project fills a gap in the understanding of the intersection between law, society, and women's economic agency during a transformative period in pre-industrial American history. These impacts can implicate the effectiveness of legislative measures in advancing …