Digital Commons Network^™

A Comparison Of Poly(Methyl Methacrylate) And Silorane-Based Cements As Carriers For Local Doxorubicin Delivery., Grahmm A. Funk, Elizabeth M. Menuey, Zachary D. Denton, Dalan M. Pittz, Alejandro Parrales, Tomoo Iwakuma, Kathleen V. Kilway, Terence E. Mciff

Manuscripts, Articles, Book Chapters and Other Papers

Orthopedic osteosarcomas and metastatic lesions can be difficult to treat with systemically delivered chemotherapy agents alone. Following removal of the primary tumor, implantation of cement to fill the lesion is often done to stabilize weight-bearing bones. One of the commonly used treatments to address osteosarcoma is systemic delivery of doxorubicin. Therefore, research on the incorporation and release of efficacious doxorubicin for local delivery from cement is important. Poly(methyl methacrylate) (PMMA)-based bone cements are the gold standard in orthopedics but have inherent disadvantages. Efforts to overcome some of these deficiencies led to the development of a novel silorane-based biomaterial (SBB). This …

Las Dos Teresas: How Women’S Critiques Of Imperialism And Patriarchy Transformed The Spanish Anarchist Movement, Stephanie Mendez

Women, Gender, and Sexuality Studies Undergraduate Honors Theses

The central question my thesis explores is how women’s participation in the Spanish anarchist movement in the late nineteenth century to early twentieth century transformed the meaning of anarchism and the anarchist movement. The anarchist movement failed to adequately acknowledge structural inequality between men and women. Women anarchists, such as Teresa Claramunt and Teresa Mañé, acknowledged this discrepancy by reimagining the practice of anarchism. They argued for the genuine expression of total liberation. This could only be achievable through the recognition of women’s subordination. They critiqued the role of patriarchy in maintaining women’s subordination. Through their vision for total liberation, …

Rationale And Trial Design Of Ribolaris: A Phase Ii Trial Of Neoadjuvant And Adjuvant Ribociclib Plus Endocrine Therapy For Clinically High-Risk Hr+/Her2-Negative Breast Cancer, Paul Cottu, Cynthia X Ma, Et Al.

2020-Current year OA Pubs

BACKGROUND: Despite advances in endocrine therapy, patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (eBC) remain at risk of recurrence (ROR). Chemotherapy is often used in high-risk cases, but not all patients benefit.

OBJECTIVES: To evaluate whether chemotherapy can be safely omitted in patients with stage II, grade 2/3 HR+/HER2- eBC who convert to low genomic risk (ROR-low) following neoadjuvant ribociclib plus letrozole.

METHODS: RIBOLARIS (NCT05296746) is an open-label, multicenter phase II trial in patients with stage II, grade 2 or 3, HR+/HER2- eBC defined as high risk based on a Ki-67 index ⩾20% …

The Protective Power Of Psychological Resources In Mitigating Burnout And Enhancing Flourishing, Dylan R. Polkinghorne, David J. Radosevich, Deirdre M. Radosevich, Dianne D. Murphy, Laken James, Sue S. Craver

Management Faculty Research and Publications

Purpose

This study explores how burnout mediates the relationships between critical psychological resources, specifically resilience, flow and self-efficacy, and flourishing in contemporary work environments.

Design/methodology/approach

Data from 374 participants, including undergraduate students at a regional comprehensive university in the Midwest and full-time working adults in the USA, were analyzed using mediation analysis in MPlus 8.11 to assess the indirect and direct effects among burnout, psychological resources and flourishing in a work environment.

Findings

Results indicate that self-efficacy significantly predicts lower burnout levels and higher flourishing. Resilience and flow were negatively associated with burnout, reducing its impact; however, the direct effects …

Cutibacterium Adaptation To Life On Humans Provides A Potential C Acnes Infection Biomarker, Md Shafiuddin, Wen-Chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney Brianna Sillart, Jonathan Z Tang, Michael R Vittori, Michael J Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P Henderson, Alexander W Aleem, Ma Xenia Garcia Ilagan, William H Mccoy 4th

2020-Current year OA Pubs

Propionibacteriaceae appear to have adapted to life on humans during the domestication of cattle. These microbial immigrants formed the genus Cutibacterium, and a descendent of those microbial trailblazers (C acnes) now dominates 25% of human skin. C acnes colonization of human skin requires the protein RoxP. Although all Cutibacteria encode this adaptation to life on humans, nothing like RoxP has been found in any other organism. In this study, we report an extensive assessment of 21 RoxP orthologs, which identified conserved molecular surfaces linked to heme-dependent oligomerization and low pH stability. Our investigation suggests how RoxP helps C acnes dominate …

Oculomics And Ai: The Eye As A Biomarker For Health Span, Joy Le Yi Wong, Rajendra S Apte, Et Al.

2020-Current year OA Pubs

As the world's population ages, the focus of healthcare is shifting from extending life span to promoting health span. There is an unmet need to identify sensitive and reliable markers of health span through more cost-effective and non-invasive methods, to enable early and effective intervention on modifiable aging factors. The eye offers a unique window into systemic health, providing direct visualization of the body's vascular and neural health. This review presents an overview of how various ocular structures can serve as biomarkers of health span-drawing on insights from ocular imaging, metabolomics, and proteomics, with evidence from basic science, animal models, …

Lost Before Forgetting: Objective Driving Metrics Track Navigation Deficits Tied To Preclinical Alzheimer's Disease, Yiqi Zhu, Ramkrishna K Singh, Semere Bekena, David C Brown, Chen Chen, Matthew Blake, Jean-François Trani, Ganesh M Babulal

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: Navigation is a complex, multisensory process in which subtle changes may emerge before the onset of symptomatic Alzheimer's disease (AD). This study investigated whether navigation abilities were associated with amyloid and tau pathology in cognitively normal older adults.

RESEARCH DESIGN AND METHODS: Among 285 cognitively unimpaired older adults, navigation and objective driving behaviors were assessed using the self-reported Santa Barbara Sense of Direction Scale (SBSOD) and a datalogger, respectively. Amyloid and tau burden were quantified using PET-MRI 2 years post-initial driving data collection. Linear mixed-effects models were used to evaluate the associations between biomarker status and longitudinal …

Techmate:: Translating Gender Equality Research Into Actionable Practice For Computing Educators, Alina Berry, Susan Mckeever, Brenda Murphy, Sarah Jane Delany

Research Outputs: 2025-Present

The persistent underrepresentation of women in computing higher education remains a global challenge, with women comprising less than 20% of ICT specialists across the EU. While substantial research has identified effective interventions to support underrepresented groups, this evidence remains fragmented across academic publications, grey literature, and institutional reports. Educators seeking to implement gender-inclusive practices face significant barriers in identifying relevant initiatives, understanding implementation requirements, and accessing practical guidance suitable for their institutional contexts. This work presents TechMate, a fully operational (https://ascnet.ie/techmate/) web-based, open-access toolkit designed to bridge the gap between research evidence and practical implementation. The toolkit consolidates over 25 …

Development Of An Active Crosslinked Nanocomposite Film Based On Gelatin-Ethyl Cellulose, Trans-Cinnamaldehyde, And Silver Nanoparticles For The Preservation Of Sliced Meat, Elham Sarmast, Shiv Shankar, Stephane Salmieri, Sahra Amel Rahmouni, Monique Lacroix

Research Outputs: 2025-Present

This study aimed to develop a novel bioactive biobased packaging film combining gelatin (G) and ethyl cellulose (EC), cardanol and glycerol as plasticizers, trans-cinnamaldehyde (TCA) as a crosslinker/bioactive compound, and silver nanoparticles (AgNPs) as bioactive agents. The degree of crosslinking, mechanical and thermal properties, water solubility (WS), and water vapor permeability (WVP) of the films were analyzed. Molecular interactions within the film matrix were determined by FTIR spectroscopy. The G-EC film, in a 1:2 weight ratio, exhibited improved physicochemical properties compared to the pure G film, with a low WS (7.8%). The incorporation of TCA and AgNPs—to form bioactive nanocomposite …

Human-Centered Evaluation Of Control And Perception Interface Factors In A Teleoperational Cutting Task, Inês F. Ramos, Keerthi Sagar, Philip Long, Maria Chiara Leva, Ernesto Damiani, Gabriele Gianini

Research Outputs: 2025-Present

Despite significant advances in teleoperated systems, optimal human performance remains a challenging task due to one key aspect, i.e. reduced situational awareness. Active telepresence is one of the major contributing factors affecting operator’s situational awareness. Providing the user with multiple perspectives of the remote environment can be very beneficial, although it may also introduce challenges in maintaining effective control. Prior work has largely examined discrete manipulation tasks using single-modality assessments, whereas this study applies a multimodal neuroergonomic approach to a continuous precision-cutting task, providing first insights into control–view alignment and multi-camera perception effects. In this work, we focus on two …

Characterization Of Nutritional And Flavor Profiles Of Aromatic Black Rice, India, Babli Waribam, Raju Sasikumar, T. Selva Kumar, Phani Kumar Garlapati, Sandeep Janghu, S. Chakkaravarthi, Paul Mansingh, Vidisha Tomer, Amit K. Jaiswal

Research Outputs: 2025-Present

Chakhao is an indigenous aromatic black rice variety from Manipur, India, valued for its distinctive flavor, high anthocyanin content, and associated health benefits. Despite its geographical indication status, limited information exists on how regional cultivation conditions influence its compositional attributes. This study characterizes and compares the nutritional composition, mineral content, volatile profile, and fatty acid methyl esters (FAMEs) composition of Chakhao sourced from five major cultivation regions in Manipur. Proximate analysis quantified moisture, protein, ash, fiber, fat, and carbohydrate content, whereas GC-MS/MS and ICP-MS were employed to profile volatile compounds, FAMEs, and mineral elements. Carbohydrates were the predominant macronutrient (73.88%–74.21%), …

Multifunctional Nanomaterials Coupled With Ai-Based Optimization For Advanced Wastewater Treatment, Ananya Tiwari, Isha Dharsandia, Shreedhar Tiwari, Gajendra Singh Vishwakarma, Budhi Sagar Tiwari, Narendra Kumar, Amit K. Jaiswal

Research Outputs: 2025-Present

Conventional wastewater treatment performs reliably against routine contaminants but remains inconsistent for complex industrial effluents and for emerging pollutants such as pharmaceutical residues, per- and polyfluoroalkyl substances and micro/nano plastics. Engineered nanomaterials and artificial intelligence (AI)/machine learning (ML) have each been reviewed extensively, but predominantly in isolation. The present review is distinguished from existing reviews in three specific respects. First, the nanomaterial-AI interface is treated as the unit of analysis rather than the two fields being surveyed in parallel: AI-guided material selection, dosing and pH control, membrane fouling prediction, nano sensor-assisted monitoring and regeneration scheduling are examined together. Second, evidence …

Assessment Of Allergenic Potential For Cross‐Reactivity Of Olive (Olea Europaea) Pit Xylo‐Oligosaccharide‐Rich Extract With Legislated Allergens In The European Union, Maame Ekua Manful, Joseph O'Shea, Antía Torres, Paz Otero, Catherine Barry-Ryan

Research Outputs: 2025-Present

Novel food sources must undergo allergenicity assessments to ensure consumer safety and regulatory compliance. Xylo-oligosaccharide-rich extract (XOS) derived from the valorization of olive (Olea europaea) pit is categorized as a novel food in the context of European Union (EU) food laws. Despite the functional benefits of xylo-oligosaccharides such as prebiotic, gut modulation, and weight management being a well-established area, there is a lack of information on the allergenic potential of olive pit-derived XOS extract. The study aimed to evaluate the cross-reactivity of olive pit-derived XOS extract with other allergens through both in vitro and in silico approaches. In vitro cross-reactivity …

Alzheimer's Disease Heterogeneity And Co-Pathologies: Defining Novel Targets, Biomarkers, Modalities, And Research Methodologies, Malú Gámez Tansey, Jorge J Llibre-Guerra, Suzanne E Schindler

2020-Current year OA Pubs

Alzheimer's disease (AD) is a biologically heterogeneous condition with vascular, proteinopathic, metabolic, and immune processes jointly shaping its clinical expression, trajectory of progression, and response to therapeutic intervention. Common AD co-pathologies such as cerebral amyloid angiopathy, Lewy body pathology, α-synuclein, and transactive response DNA-binding protein of 43 kDa (TDP-43)/limbic-predominant age-related TDP-43 encephalopathy are also increasingly connected with cognitive decline and therapeutic response. Significant advances in biomarkers, including seed amplification assays, proteomic signatures, and emerging positron emission tomography tracers bolster the field's understanding of a biological staging model and discovery of previously unrecognized co-pathologies. The Fall 2025 Alzheimer's Association Research Roundtable …

Steroid Hormone Metabolites And Mammographic Breast Density In Premenopausal Women, Ghazaleh Pourali, Kayode A Matthew, Myung Sik Jeon, Chongliang Luo, Gary J Patti, Jingqin Luo, Adetunji T Toriola

2020-Current year OA Pubs

BACKGROUND: Steroid hormones influence breast morphology and cellular proliferation and are associated with breast carcinogenesis. However, their associations with mammographic breast density (MBD) are less studied, particularly in premenopausal women. We, therefore, investigated the associations of steroid hormone metabolites with MBD in premenopausal women.

METHODS: Our study included 700 premenopausal women scheduled for screening mammograms. We analyzed 54 steroid hormone metabolites (Metabolon®) and assessed volumetric measures of MBD including volumetric percent density (VPD), dense volume (DV), and non-dense volume (NDV) using Volpara. We investigated associations using linear regression modeling to estimate the covariate-adjusted means of VPD, NDV, and DV, corresponding …

Implementing The Lung Donor (Lundon) Acceptability Score In U.S. Donor Management And Transplant Decision-Making: A Multi-Aim, Mixed-Methods Protocol, Nikki E. Rossetti, Su-Hsin Chang, Yan Yan, Graham Jaensch-Frie, Charles R. Liu, Nahom Y. Seyoum, Meghna Katta, Arvind Kumar, Zhizhou Yang, Christian Oncken, Christy Hamilton, Kyle Stumbaugh, Brendan Heiden, Sarah Peskoe, Varun Puri, Et Al.

2020-Current year OA Pubs

BACKGROUND: Despite advances in transplantation science, a persistent shortage of donor lungs continues to limit access to life-saving lung transplants. The Lung Donor (LUNDON) Acceptability Score is a validated tool that predicts donor lung utilization and post-transplant recipient outcomes, but integration into practice remains limited. This study will evaluate determinants of LUNDON score adoption, its impact on clinical decision-making, and develop tools to support its implementation.

METHODS: This is a multi-aim mixed-methods pre-implementation study that will be conducted across U.S. Organ Procurement Organizations (OPOs) and lung transplant centers. Aim 1 will identify barriers and facilitators of LUNDON score adoption through …

Subcutaneous Infliximab For Inflammatory Bowel Disease: Clinical Evidence, Pharmacokinetics, And Implementation Challenges, Mir Zulqarnain, Parakkal Deepak, Andres J. Yarur

2020-Current year OA Pubs

No abstract provided.

Hierarchical Bayesian Regression For Experimental Psychology: A Case Study Of Cognitive Control, Thomas A Dudey, Joshua J Jackson, Shelly R Cooper, Todd S Braver

2020-Current year OA Pubs

Arising from the so-called 'replication crisis' in the experimental psychology literature, there has been a growing call to reassess whether specific analytic practices might enhance the accuracy and precision of reported findings. This issue is explored here, through a case study examination of two previously collected datasets from the Dual Mechanisms of Cognitive Control (DMCC) task battery. This case study highlights the unique advantages afforded by Hierarchical Bayesian Regression (HBR) models as a potentially more rigorous analytic approach to statistical inference. In the DMCC datasets, two sets of HBR models are presented, with the estimates of the former used as …

"Using Theories" And "Doing Theory": Tool And Action Orientations To Theory At The Interface Of Public Health And Anthropology, Peter Taber, Eileen M Dryden, Jean M Hunleth, Linda S Kahn, Lance Laird, Teresa Winstead, Genevra F Murray

2020-Current year OA Pubs

The use of "theory" is a common concern in public health and anthropology. However, the term can have quite distinct meanings. In this piece, we seek to name and characterize some tendencies in anthropological theorizing that contribute to potential misunderstandings when communicating with non-anthropologist colleagues in public health. In particular, we highlight differences between the use of recognizable, named "theories" that often explicitly frame public health research and interventions, and the open-ended and context-specific work of "doing theory" sometimes referenced in anthropology. Observing the linguistic shifts entailed to refer to theory in each of these cases-"using theories" versus "doing theory"-we …

Multi-Institutional Mri-Based Radiomic Pilot Study To Measure The Variations Between Scanner Vendors And Imaging Sessions, Suong Duong, Danny Lee, Carri Glide-Hurst, Bhudatt Paliwal, Jennie Crosby, Michael Boss, Yunfeng Cui, Mi Huang, Heng Li, Khadija Sheikh, Taeho Kim, James Monroe, Jung Hun Oh, Ying Xiao, Jason W Sohn

2020-Current year OA Pubs

BACKGROUND: Multi-institutional clinical trials frequently use MRI imaging for critical decisions and guidance for medical treatments. Collecting and analyzing images produced by various MR vendors and models is quite difficult since image quality can be highly variable. No unifying quality control targeting protocol studies exists to ensure MRI images used in that study are comparable. This project will investigate variations between imaging sessions and between various scanners using radiomic parameters from prototype MRI QA phantom.

PURPOSE: To develop a 3D radiomic phantom for quantifying radiomic feature consistency between MRI scanners across multi-institutions.

METHODS: The prototype phantom consists of five 3D-printed …

Real-World Use Of Theophylline In Critically Ill Patients With Sinus Pauses: A Case Series, Muhammad Ali Elahi, Hamza Jalal, William Frick, Bryan D Kraft

2020-Current year OA Pubs

BACKGROUND: A sinus pause is is defined as a delay in sinus node depolarization exceeding 3 s following atrial depolarization. In patients with pauses greater than 5 s accompanied by hemodynamic compromise, the primary treatment is permanent pacemaker (PPM) implantation. However, in the presence of an active infection, alternative strategies such as temporary transvenous pacing or pharmacologic agents may be more appropriate. This report highlights the use of theophylline as a non-invasive therapeutic option in two patients with asymptomatic sinus pauses who had contraindications to PPM placement.

CASES: Patient A was a 74-year-old woman with a history of pulmonary arterial …

Validity Of The Promis Ability To Participate In Social Roles And Activities Measure In Older Adult Health Assessment, Theresa Raudsepp

Faculty Publications - College of Physical Therapy

Objective: The International Classification of Function is often used in older adult clinical assessments. Well recognized is the high value, and difficulty, of assessing participation in social roles. The PROMIS Ability to Participate in Social Roles (APSR) measure may augment assessments enhancing our understanding of older adults’ participation in social roles. The purpose of this study was to examine whether the APSR diverges with other clinical measures suggesting it is measuring a separate construct adding new information to the clinical assessment.

Methods: A sample of convenience of older adults (n = 89) was recruited and administered clinical assessments that include …

Enhancing Team Science By Training Collaborative Biostatisticians To Have A Strong Statistical Voice, Gina-Maria Pomann, Steven C. Grambow, Marissa C. Ashner, Bibhas Chakraborty, Nan Liu, Megan L. Neely, Sarah Peskoe, Lacey Rende, Emily Slade, Tracy Truong, Lexie Zidanyue Yang, Greg P. Samsa, Jesse D. Troy

Biostatistics Faculty Publications

Strong statistical voice is defined as the ability to advocate and negotiate for good and ethical statistical practices, including integrating and resolving differing scientific approaches. This skill is crucial for biostatisticians who work on biomedical research teams, as it ensures the integrity and accuracy of statistical analyses and fosters productive collaborations with non-statisticians. Despite its importance, new graduates often lack targeted training opportunities. This manuscript presents a scalable training approach through the development of online videos. Preliminary didactic materials focused on two key applications: providing written comments on manuscripts and engaging in study design discussions. To evaluate this training approach, …

Should The Illiberal Arts Be Servile In A Classical Christian Education, Nadine B. Kong Mrs.

Master of Arts in Classical Studies

The purpose of this thesis is to research the role and position of the illiberal arts in a classical Christian education (CCE).  The current climate of growth for CCE makes it a fitting moment to consider what bearing the illiberal arts should have on paideia formation.  To answer this question, the historical context of CCE and the illiberal arts is presented.  This leads to a complex issue around the various imprecise terms and historical attitudes surrounding the illiberal arts.  Some synonymous terms have demeaning connotations: ‘servile arts’ or ‘illiberal arts,’ and others less negative, such as ‘common arts’ or ‘mechanical …

Create Scj Prefix, Communication And Journalism

Program Revisions/Additions

No abstract provided.

Litigating The "Forever Chemical" Problem Through The Endangered Species Act, Charlotte A. Ramirez

Emory Law Journal

Per- and polyfluoroalkyl substances (PFAS), a class of man-made, resiliently bonded chemicals, cause harm to both humans and animals. These “forever chemicals” can compromise immunity, increase cancer risks, and cause reproductive harm. Addressing the harms caused by PFAS variants is crucial to protect public health, environmental health, and biological diversity. However, the United States’ current regulatory scheme takes a disjointed approach to PFAS regulation. This is complicated by the frequent development of new PFAS variants, whose effects and environmental presence are largely unknown and understudied. While even the protections provided for humans under the current regulatory scheme fall short of …

Techno-Optimism In Innovation Law And Policy, Peter Lee

Emory Law Journal

This Article examines an underappreciated bias that has long pervaded U.S. legal culture: an exceedingly enthusiastic view of technology and technological progress. It adopts the term “techno-optimism” to describe an asymmetrically positive view of innovation that extols its benefits, minimizes its harms, and elides much of its complexity. The recent rise of more skeptical attitudes toward technology only casts into sharper relief the techno-optimism that has subtly dominated policy debates for decades. As a case study of techno-optimism, this Article scrutinizes patent law, particularly its constitutionally defined objective of promoting technological progress. In so doing, it offers the first extended …

When Machines Collude: Rebooting Antitrust Law For The Age Of Algorithmic Markets, William K. Knight

Emory Law Journal

Increasingly, our lives are being dominated by algorithms. From social media feeds to credit scoring, algorithms play a major role in our day-to-day lives, whether we recognize it or not. An emerging issue in the modern technology landscape is the potential for algorithms to cause anticompetitive harm to free markets. As pricing algorithms become more advanced and more widespread, they could facilitate collusive arrangements in a manner that bypasses antitrust laws, thereby adversely impacting consumers through higher prices. American competition law, primarily governed by the Sherman Antitrust Act, suffers from glaring deficiencies and ambiguities that remain unresolved, leaving it manifestly …

Addiction To Constitutionally Protected Activity: Speech, Press, And Religion, Eugene Volokh

Emory Law Journal

Recent statutes and lawsuits have sought to restrict social media or video game design practices that supposedly cause some users to become “addicted.” Are such restrictions consistent with the First Amendment?

This Article begins by asking what would happen if the same arguments were applied to religious practices (whether or not the arguments’ supporters would seek to so apply them). Say some religious practice was viewed as causing emotional or financial harm—e.g., by leading some adherents to feel guilty about their sexuality, to distance themselves from family members, or to give substantial portions of their assets to the religious organization. …

The Public Utility Tradition In Antitrust Remedies, Ganesh Sitaraman

Emory Law Journal

Historically, courts, jurists, legislatures, and scholars have recognized that some businesses provide important services to society in sectors in which competition is unlikely to achieve the public interest. Policymakers adopted statutes that comprehensively regulated the market structure and operations of these businesses as public utilities, including, among other things, by determining entry and exit into business lines; overseeing or affirmatively setting prices; and requiring uniform, nondiscriminatory sales and access. When policymakers had not—or had not yet––stepped in to legislatively regulate these enterprises, abuses of power were possible. Private plaintiffs and governments sued under the common law or antitrust laws to …