Digital Commons Network^™

Mandatory Cooperation Under International Law, Evan J. Criddle, Evan Fox-Decent

Faculty Publications

Humanity in the twenty-first century faces serious global challenges and crises, including pandemics, nuclear proliferation, violent extremism, refugee migration, and climate change. None of these calamities can be averted without robust international cooperation. Yet, national leaders often assume that because their states are sovereign under international law, they are free to opt in or out of international cooperation as they see fit. This book challenges conventional wisdom by showing that international law requires states to cooperate with one another to address matters of international concern – even in the absence of treaty-based obligations. Within the past several decades, requirements to …

Bilingual Teacher Advocacy, Agency, And Leadership: A Model For Teacher Education And Professional Development, Grace Jue Yeon Kim, Zhenjie Weng, Jingyi Zhu

Faculty Journal Articles

Research has examined bilingual teachers’ work and their

experiences through the theoretical lens of teacher advocacy,

teacher agency, and teacher leadership. This research synthesis

analyzes the current research on the three frameworks in bilingual

education and examines how they intersect. Bilingual teachers

advocated for educational change to address the needs of

emergent bilinguals. Despite various context-specific constraints,

bilingual teachers agentively created bilingual spaces for

linguistically diverse students. Furthermore, bilingual teachers

actively took up leadership roles, demonstrated increased

consciousness, and developed leadership identities. Through this

exploration, this paper proposes a model that integrates the three

frameworks for bilingual teacher education and …

Beyond Mean Length Of Utterance: Novel Measures For Characterizing The Spoken Language Of Autistic Children, Janine Mathee-Scott, Courtney E. Venker

Speech Pathology and Audiology Faculty Research and Publications

Purpose:

Mean length of utterance (MLU) is a common measure of expressive language complexity in young children, including autistic children. However, means, by nature, obscure some information about spread and variability in data. Thus, we aimed to examine a new approach to characterizing linguistic complexity in autistic children by investigating the validity of two novel measures—range of length of utterance (RLU), standard deviation of length of utterance (SDLU)—alongside established measures: MLU and total utterances (TU).

Method:

Participants were 40 autistic children (12 girls, 28 boys; M_age = 41.78 months). Children participated in 10-min, play-based language samples with their caregivers. …

Optimizing Tbi Care: Brain Oxygen Monitoring In Nursing - An Evidence-Based Practice, Alyssa Grisham

Loma Linda University Electronic Theses, Dissertations & Projects

Purposes/Aims

This DNP project aims to enhance the care of patients with traumatic brain injury (TBI) by improving nurses’ knowledge, clinical decision-making, and early intervention strategies through the integration of brain oxygenation data into routine neurocritical care assessments. This project seeks to promote personalized patient care, reduce secondary brain injury, and improve neurological outcomes for critically ill adults with TBI by implementing an educational protocol designed to deepen understanding of brain oxygen monitoring.

Background of Problem & Description of Current Practice

TBI remains a leading cause of death and disability worldwide and continues to pose a significant public health burden. …

Dismantling The Whiteness Of Legal Education, Doron Samuel-Siegel

Law Faculty Publications

Whiteness is not merely a racial description. Whiteness operates as allegiance to structural racism. The quiet engine of racial hierarchy, whiteness pervades and shapes traditional legal education, rendering legal pedagogy a structurally racist enterprise. Legal education not only reproduces the racism embedded in the law and legal profession, but also obscures the ways legal doctrine, professional norms, and pedagogical practices normalize, protect, and make invisible the advantages that accrue to whiteness itself. In doing so, itproduces lawyers ill-equipped to dismantle structural injustice.

This Article breaks new ground in the scholarship on legal pedagogy by defining whiteness as it operates within …

Computational And Ai Literacy: Lessons Learned From Computer Science Education, Sharin Jacob, Yenda Prado, Quinn Burke

Journal of Computer Science Integration

This conceptual paper explores the intersection of computational thinking (CT) and artificial intelligence (AI) literacy, proposing a framework integrating AI literacy into existing computational literacy models. We argue that computational thinking (CT) skills form the foundation for AI literacy, and that lessons learned from decades of computer science (CS) education research can ably guide the development of AI literacy instruction for a wide range of  students and within integrative contexts. Drawing on Kafai and Proctor's (2022) conceptualization of computational literacy, as well as encompassing cognitive, situated, and critical dimensions, we extend their framework to advance our understanding of AI literacy. …

Replication Study Of Leadership Approaches Federal Employees Find Effective For Enhancing Morale And Productivity, Bobby Orozco

Dissertations

This study used the full range leadership model (FRLM) and lead-member exchange theory to examine leadership’s impact on federal employee morale, trust, engagement, and performance. A descriptive qualitative study design involved semistructured interviews with 16 nonsupervisory transportation security officers (TSO) at nine Northern and Southern California airports. Participants had a minimum of 2 years federal employment and 1 year union representative experience. Audio recorded interviews were transcribed verbatim and thematically analyzed using NVivo software. Organizational documents were also used to triangulate interview data. Results revealed an inspirational, caring, and collegial leadership style was most effective in enhancing morale and productivity. …

Human Resources Professional’S Job Practices In Manufacturing That Impact Employee Job Satisfaction And Retention, Alma Rosa Avalos

Dissertations

Purpose: The purpose of this explanatory sequential mixed methods study was to identify and describe employee job practices in the manufacturing industry as perceived by HR professionals that impact employee job satisfaction. The second purpose of this study was to determine which employee job satisfaction practices have the most impact on employee retention as perceived by HR professionals.

Methodology: An explanatory sequential mixed methods design examined the perceptions of 30 purposively selected Los Angeles County HR professionals. Data was collected through an online survey and interviews and analyzed using descriptive statistics, frequency tables, and qualitative analysis.

Findings: HR professionals consistently …

When Nigeria Happens To You: Finding Effective Leadership Approaches For Crisis Management And Organizational Resilience Among Nigerian Leaders, Grace Odim

Dissertations

Purpose: The purpose of this phenomenological study was to explore how Nigerian SME leaders interpret and apply leadership strategies to manage crises and build organizational resilience in volatile environments. The study focused on key dimensions of leadership, including strategic crisis navigation and vulnerability assessment, organizational resilience, contextual leadership, experiential learning and innovation, and organizational sustainability.

Methodology: This study employed a qualitative phenomenological research design to examine the lived experiences of Nigerian SME leaders who had navigated significant organizational crises. Participants were purposefully selected based on their direct experience managing disruptions that affected their businesses. Data were collected through semistructured interviews …

Neurofilament Light Chain But Not Glial Fibrillary Acidic Protein Serum Levels Are Elevated In Wolfram Syndrome, Matthew J Jansen, Heather M Lugar, Cris M Brown, Abby F Tang, Liam J Oiknine, Ling Chen, Jonathan M Koller, Brian A Gordon, Bess A Marshall, Fumihiko Urano, Tamara Hershey

2020-Current year OA Pubs

BACKGROUND: Wolfram syndrome is a rare genetic disorder caused by pathogenic variants in the

OBJECTIVE: To determine if serum NfL and/or GFAP levels are elevated in Wolfram syndrome compared to controls and whether they can serve as monitoring biomarkers.

METHODS: Serum NfL and GFAP levels were log

RESULTS: NfL levels were higher in the Wolfram group relative to all control groups (

CONCLUSION: Serum NfL elevation in Wolfram syndrome may reflect the ongoing, relatively slow neurodegeneration occurring in this disorder. However, without any correspondence between serum levels and currently used clinical and neuroimaging metrics, it has limited utility as a …

Insulinemic And Inflammatory Dietary Patterns And Colorectal Cancer Risk: A Dietary Data Harmonization Study Of One Million Participants In The Consortium Of Metabolomics Studies (Comets), Ni Shi, Rachel Hoobler, Rhea Harewood, Amanda E Toland, Demetrius Albanes, Emmanouil Bouras, Marc J Gunter, Linda M Liao, Steven C Moore, Fulvio Ricceri, Jerome I Rotter, Rashmi Sinha, Rachael Stolzenberg-Solomon, Anne Tjønneland, Alexis C Wood, Danxia Yu, Mary C Playdon, Fred K Tabung

Children’s Nutrition Research Center Staff Publications

Background: Inflammatory and insulinemic dietary patterns have been associated with colorectal cancer (CRC) risk, but generalizability across diverse populations with heterogeneous food supplies and dietary behaviors has not been established.

Objectives: We harmonized disparate dietary and covariate data on a large scale to compute the reverse Empirical Dietary Index for Hyperinsulinemia (rEDIH), reverse Empirical Dietary Inflammatory Pattern (rEDIP), and Healthy Eating Index (HEI)-2015 scores, and tested their associations with CRC risk.

Methods: We leveraged data among 501,892 women and 407,390 men from 6 cohorts across the United States (NIH-AARP, Multi-Ethnic Study of Atherosclerosis, Prostate, Lung, Colorectal, and Ovarian, SCCS) and …

Liability For Non-Disclosure In Ipos, Albert H. Choi, Kathryn E. Spier

Articles

A privately-informed entrepreneur may withhold material information from prospective investors who may sue the firm ex post for (alleged) non-disclosure. Absent liability, the entrepreneur has an excessive incentive to withhold bad news and pursue socially-wasteful projects. Liability deters inefficient non- disclosure and prevents capital misallocation. Any damage award received by investors is partially offset by a reduction in equity value. Depending on the likelihood of court error and litigation cost, the socially-optimal damage award may be either zero or the minimum necessary for full deterrence. The private incentive to waive liability may be socially excessive or insufficient. Positive and normative …

Can – And Should – The Un Charter Be Saved?, Steven Ratner

Articles

World leaders from Canada’s Mark Carney to Germany’s Friedrich Merz have announced the demise of the international rules that provided some degree of order to international relations since the Second World War.2 The immediate cause is clear to them and others – a seeming abandonment of international law, and the UN Charter in particular, by the United States government, its chief architect and advocate. The U.S. actions and rhetoric over Venezuela and Iran – wars the United States has started – as well as Greenland and Ukraine seem to have confirmed the worst about the future of international law.

Interpretive Facts: Textualism, Empiricism, And The Law-Fact Divide, Hannah Walser

Articles

This Article offers the first systematic examination of where empirical linguistic evidence should fit in the federal court system's division of labor based on law and fact. I begin by identifying interpretive facts : generalized empirical evidence about how a particular word or phrase has been used by a population of speakers, understood by a population of listeners, or both. Thanks to technological advances in corpus linguistics permitting the quantitative analysis of large numbers of texts, as well as methodological shifts that frame ordinary meaning as an empirical question, such facts are increasingly prominent in statutory and constitutional interpretation cases. …

(Reverse) Piercing The Trust Veil, Eric Kades

Faculty Publications

Emergent doctrine deems trusts legal entities distinct from their trustees and beneficiaries. Venerable doctrine empowers creditors to "pierce the veil" separating entities' and their owners' property to avoid inequitable treatment. This article weaves together the new and old to craft a legal roadmap for reversing the ongoing race to the bottom among the states authorizing indefensible self-settled asset protection trusts (SSAPTs) designed solely for the purpose of swindling creditors. As a matter of both policy and doctrine, piercing (more precisely, reverse piercing) an entity's veil is ideally suited to empower the creditor of a SSAPT beneficiary to get paid from …

Where We Go When Reality Hurts: The Comfort Of Story, Margaret Nebens

Theses and Dissertations

No abstract provided.

Repurposing Of Fda-Approved Drugs Identifies Glipizide As A Potent Hmg-Coa Reductase Inhibitor: A High-Throughput Virtual Screening And Molecular Dynamics Approach For Targeting Hypercholesterolemia, Parvej Ahmad, Eswara N. Hanuma Kumar Ghali, Sahir S. Alvi

School of Medicine Publications

Purpose:

Atherosclerotic cardiovascular disease (ASCVD) is one of the leading causes of mortality worldwide. Several inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-R), the key hepatic cholesterogenic enzyme, are prescribed to treat hypercholesterolemia and ASCVD. Statins, the established HMG-R inhibitors, exhibit promising cholesterol-lowering effects; however, their long-term use has prompted significant concerns, necessitating the search for additional therapeutic candidates with strong HMG-R inhibitory activity. Therefore, this study aims to find potential HMG-R inhibitor/s that may help reduce excess cholesterol levels via targeting HMG-R activity.

Methods: In this study, 1285 FDA-approved small molecules were assessed for their HMG-R inhibitory potential using …

Introduction To Trigger Warnings: Teaching Through Trauma, Ian Barnard, Ryan Ashley Caldwell, Jada Patchigondla, Aneil Rallin, Morgan Read-Davidson, Ethan Trejo, Kristi M. Wilson

English Faculty Books and Book Chapters

"The individual histories of both trigger warnings and trauma have evolved rapidly in the overlapping wakes of COVID, mental health crises, attacks on educational institutions in the United States, climate apocalypse, evergrowing economic inequities, and, more promisingly, attempts at political redress and educational equity. At the same time, trigger warnings and trauma have become exponentially more intimately linked in the past few years. But however often the topic of trigger warnings provokes heated discussion, the appeals and alignments of the interlocutors equally as frequently defy neat political binaries. Critiques of trigger warnings come from all sides of the political and …

Trigger Warnings And A Pedagogy Of Trust, Morgan Read-Davidson

English Faculty Books and Book Chapters

"While the larger conversation about difficult content and trigger warnings is not new, the sudden need for urgently scheduled meetings with me did not begin until the COVID- 19 pandemic crisis and our move to remote instruction, and the subsequent adjustment back to the classroom. This seems to coincide with the increase of online and social media interaction during the pandemic, where the use of trigger warnings and content warnings on social media, particularly on Twitter, Instagram, and TikTok, have made the conversation far more visible. For students, this seems to have given them validation and confidence, as well as …

Vestibular Migraine And Ssri Withdrawal: A Case Presentation, Grace Fairchild, Sarah Redding, Ashley Flagge

V&B Presentations

No abstract provided.

Searching For Cause Of Unexplained Protein Interaction With Multiple Assembly Methods, Gavin Anderson

Master's Projects

Research into colistin adjuvants has identified interactions between a host of proteins and proteins found within certain strains of bacteria. BLAST, a widely adopted local sequence alignment tool, was used to create a database containing the genomes of relevant bacterial strains, which would then be used to query against the previously identified proteins. Many of these strains do not have publicly available assemblies, which makes database construction difficult. CATwalk, a new naïve fragment extender, is first described in this paper and used to extend fragments of interest. BLAST results first identified short fragments with sufficient similarity, which can then be …

Cost-Aware Predictive Routing For Vision-Language Models, Sahil Sait Naveed

Master's Projects

Vision-language models (VLMs) are increasingly used for multimodal tasks, but their inference costs vary widely across model tiers. This work presents a predictive routing framework that assigns each query to the most cost-effective VLM by using multimodal embeddings, clustering, and per-cluster model error estimates. Evaluated on six commercial VLMs, the selected router reduces average cost by about 49 percent relative to the quality-first setting on both validation and test. This comes with accuracy losses of 0.4 percentage points on validation and 0.9 on held-out test data. It also outperforms K-NN and ZeroRouter routing baselines while providing lowercost operating points than …

Stepwise Sudoku Reasoning Training Using Transformers, Lok Man Chu

Master's Projects

Sudoku is a constraint satisfaction problem that serves as a testbed for studying reasoning and stepwise deduction. While many solvers can produce correct solutions, they often fail to generate human interpretable sequences of logically consistent steps. This study investigates whether a transformer trained on stepwise deduction traces can learn to solve Sudoku puzzles through sequential, logically deducible moves. Results show that solve accuracy improves significantly with more training data, reaching approximately 78% at 1500k samples. Stepwise analysis indicates that the model effectively learns simple strategies, achieving near-perfect performance. However, performance on more complex strategies remains limited. Overall, while the model …

Cerebellar Motor And Non-Motor Contributions To Dystonia Pathophysiology And Treatment, Linda H Kim, Cheryl Brandenburg, Roy V Sillitoe

Duncan NRI Faculty and Staff Publications

Dystonia is a complex neurological disorder characterized by sustained or intermittent abnormal movements and/or postures. However, dystonia's non-motor symptoms, particularly the sleep disturbances, are critical yet underexplored concerns that affect all ages. Here, we synthesize current knowledge on the motor and non-motor domains of dystonia, emphasizing the functional interconnections and plasticity within cerebellar motor, cognitive, and sleep-associated circuits to motivate more comprehensive and effective treatments that improve overall quality of life.

Putting The L In Elsi: Legal Methods For Bioethics Research, Anya E R Prince, Benjamin Berkman, Donald Ford, Dov Fox, Christi Guerrini, Amy Koopmann, Natalie Ram, Jessica L Roberts, Kayte Spector-Bagdady, Sonia Suter

Center for Medical Ethics and Health Policy Staff Publications

Lawyers and law professors are increasingly involved in interdisciplinary scientific teams and grant research to answer ethical, legal and policy questions related to biomedical topics. Yet, the methods that lawyers use to conduct legal research and analysis are not always familiar to scientists and social scientists conducting peer review of a proposed project with legal aims or a publication reporting a legal study. To better facilitate interdisciplinary ethical, legal, and social implications collaboration, there is a need to better explain how legal research methodologies can provide robust tools to address a range of nuanced biomedical questions. This paper explores …

Differences Between Government, Consortium, And Private Database Stewards Impacting The Genomic Data Market: A Survey Of U.S. Academic Genetic Researchers., Amanda K Greene, J Denard Thomas, Kaitlyn Jaffe, Luyun Chen, Kerry A Ryan, Brian J Zikmund-Fisher, J Scott Roberts, Amy L Mcguire, Katherine Hendy, Kayte Spector-Bagdady

Center for Medical Ethics and Health Policy Staff Publications

Background: Despite major shifts in U.S. federal government data sharing requirements, their impact, and relation to researcher choice of database, are underexplored. This study surveyed genetic researchers regarding trends, priorities, perceptions of quality, impact on research outcomes, and genomic data sharing and use across government, consortium, and private databases.

Methods: As part of an exploratory sequential mixed methods project, we surveyed 294 U.S.-based genomic academic researchers.

Results: Genetic researchers generally have a choice between databases, which allows them to prioritize data quality. This might explain recent trends toward the use of government and consortium databases away from private ones. Respondents …

Can I Get A Witness? The Ethical Dimensions Of Family Presence In Patient Suffering, Jennifer Blumenthal-Barby, Trevor M Bibler, Holland Kaplan, Adam Omelianchuk, Joanna Smolenski

Center for Medical Ethics and Health Policy Staff Publications

For patients who are suffering, the bedside presence of a family member can provide comfort, and many people hold that there is moral value in being present with a conscious, suffering patient. Yet what is the moral significance of the absence of family members when a patient is minimally conscious or unconscious and not aware of their absence? Clinicians are often troubled when family members and surrogate decision-makers who are able to spend a significant amount of time at an unconscious, seriously ill patient's bedside do not do so. Clinicians feel frustrated that they must bear the burden of witnessing …

Anything But Endo: Diagnostic Buck-Passing In Endometriosis Diagnosis, Rita Dexter, Megan Kitts, Heather Welty, Melanie Jeske

Center for Medical Ethics and Health Policy Staff Publications

People living with endometriosis, a disease in which tissue similar to the lining of the uterus grows elsewhere in the body, often experience prolonged diagnostic journeys because of symptom variability, normalisation of period pain and other symptoms, and lack of awareness of the condition. In this article, we analyse the endometriosis diagnostic journey through the lens of epistemic injustice. Drawing on in-depth interviews with 52 people living with endometriosis in the United States, we introduce the concept of diagnostic buck-passing to characterise the phenomenon wherein individuals who seek treatment for their symptoms end up stuck in a cycle of seeing …

Toward Ethical Provenance Tracking: The Ga4gh Model Data Access Agreement (Daa), Alexander Bernier, Bartha Maria Knoppers, Jonathan Lawson, Robyn Mcdougall, Maili Raven-Adams, Vasiliki Rahimzadeh

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Standardizing contractual clauses that govern data access enables research institutions to responsibly steward genomic and related health data while enabling its efficient downstream reuse.

Methods: We describe a document analysis study using both qualitative and comparative law analytical approaches to identify the most common categories of clauses from 29 different data access agreements used by human biomedical research consortia globally. We furthermore characterized the legal positions and standard practices for each common element of the agreement and synthesized across them to develop model clauses. A total of 3 discussion sessions were organized virtually to refine the clauses among members …

Imagining Genomics And Population Health In 2050: Anticipating Future Research, Policy, And Governance Needs, Bartha Maria Knoppers, Yann Joly, Ma Apos N H Zawati, Habiba Alsafar, Jeffrey C Barrett, Laura Blackburn, Brian Hon-Yin Chung, Martina C Cornel, Edward S Dove, David Glazer, Calvin Wai-Loon Ho, Muin J Khoury, Anna C F Lewis, Anneke Lucassen, Peter F R Mills, Colin Mitchell, Nicola Mulder, Ainsley J Newson, Anthony Ng, Paul D P Pharoah, Vasiliki Rahimzadeh, Megan C Roberts, Saskia C Sanderson, Jeffrey M Skopek, Ron Zimmern, Eric M Meslin

Center for Medical Ethics and Health Policy Staff Publications

No abstract provided.