Digital Commons Network^™

Psilocybin And Animal Testing: Charting An End To The Use Of Animals In Drug Development Research, Amanda L. Elyse

Journal of Health Care Law & Policy Online Issue

No abstract provided.

Justice For Our Nation's Elders: Why The Health & Hospital Corporation V. Talevski Decision Is A Victory For Elder Rights, Aryana Ravery

Journal of Health Care Law & Policy Online Issue

No abstract provided.

City Of Grants Pass, Oregon V. Johnson: The Intersection Of Health, Homelessness, And Eighth Amendment Protections Against Cruel And Unusual Punishment, Jordan Hartung

Journal of Health Care Law & Policy Online Issue

No abstract provided.

Teaching Multiculturalism With A Christian Worldview To Influence Perspectives: Combating Emotions And Challenging Presuppositions Of Counselors, Steven Brooks

Faculty Publications and Presentations

In counseling education, teaching multiculturalism is a critical curricular component. Today, counselors (more widely defined as various caregivers) are more likely to encounter people whose race or culture differs from their own. Therefore, to be the most effective counselor, a solid and unapologetic curriculum in multiculturalism should be required. Because the education component of multiculturalism is often subordinate to a trainee’s reluctance—or even inability—to confront the difficult concepts, it is necessary first to address the reluctance; hence, my thesis. Multiculturalism presented and discussed on an academic plane is more likely to assuage trainees’ fears and spur them to cultural competence. …

Repurposing Erisa As The Protector Of Health Insurance Beneficiaries, D. Brian Hufford

Journal of Health Care Law & Policy Online Issue

No abstract provided.

Mandibular Extension As A Trigger Of The Proprioceptive Trigeminocardiac Reflex, Massimo Conti, Giovanna Traina, Daniele Tonlorenzi

Turkish Journal of Medical Sciences

The trigeminocardiac reflex (TCR) is a physiological response characterized by a reduction in heart rate and arterial blood pressure following stimulation of any branch of the fifth cranial nerve. This review presents a novel mechanism of TCR induction through proprioceptive activation of the trigeminal nerve via mandibular extension (ME). Accordingly, it is referred to as the “proprioceptive trigeminocardiac reflex” (pTCR). An overview of the existing literature on ME-evoked TCR in humans and animals is presented, with particular emphasis on evidence of cerebral microcirculatory alterations. The magnitude of cardiovascular responses appears to depend on the duration of ME, with repeated applications …

Heavy Metals As Endocrine Disruptors, Arzu Or Koca

Turkish Journal of Medical Sciences

Heavy metals are widely recognized as endocrine-disrupting agents primarily originating from anthropogenic sources and persisting in soil, air, and water. This review aims to present an updated and comprehensive synthesis of current evidence regarding the endocrine-disrupting effects of heavy metals, with particular emphasis on their roles in the pathogenesis of common endocrine and metabolic disorders. The toxicological impact of these elements depends on the level and duration of exposure, their chemical form, and the biological susceptibility of target tissues. Chronic exposure, even at low doses, has been implicated in the development of diabetes mellitus, obesity, autoimmune thyroiditis, thyroid cancer, pubertal …

Canakinumab Treatment In Patients With Colchicine-Resistant Familial Mediterranean Fever: A Multicenter Observational Study, Emrah Koç, Mete Pekdi̇ker, Mete Kara

Turkish Journal of Medical Sciences

Background/aim: Anti-interleukin-1 agents have known beneficial effects in the treatment of colchicine-resistant familial Mediterranean fever (cr-FMF); however, studies to date have tended to have small sample sizes and to be based on pooled data. The present study investigates the efficacy of Canakinumab (CAN) in a homogeneous cohort of cr-FMF cases.

Materials and methods: The study included patients who underwent treatment in three tertiary rheumatology departments, whose electronic medical records were reviewed retrospectively. The inclusion criteria were presence of colchicine resistant disease activity or persistent proteinuria secondary to AA-amyloidosis, and treatment with CAN for at least 6 months. Clinical and laboratory …

Evaluation Of The Relationship Between Pan-Immune Inflammation Value And Prognostic Factors In Germ-Cell Testicular Cancer: Analysis Of Stage, Lymph Node Involvement, And Metastasis, Erdi̇nç Di̇nçer, Orkunt Özkaptan, Cengi̇z Çanakçi, Osman Murat İpek, Alper Coşkun, Ahmet Hali̇l Sevi̇nç

Turkish Journal of Medical Sciences

Background/aim: To evaluate the association between the preoperative pan-immune inflammation value (PIV) and prognostic factors, including stage, lymph node involvement, and metastasis, in patients who underwent radical orchiectomy for germ cell testicular tumors.

Materials and methods: Data from 178 patients who underwent radical orchiectomy for testicular tumors between January 2014 and January 2024 were retrospectively reviewed. Preoperative serum tumor markers, hematologic parameters, and histopathological findings were recorded. Tumor staging was determined based on radiological imaging and serum tumor markers. The PIV was calculated using the formula: (monocyte count × neutrophil count × platelet count) / lymphocyte count. Optimal cut-off values …

Validity Of The Turkish Version Of The Oral Frailty Index-8 And Its Relationship With Frailty, Malnutrition, And Sarcopenia In Older Adults, Süleyman Emre Koçyi̇ği̇t, Bi̇lal Kati̇poğlu, Yilmaz Önal, Kübra Bahar Baykan, İlknur Şeker Kaya, Fatma Sena Dost, Özge Dokuzlar, Esra Ateş Bulut, Ali̇ Ekrem Aydin, Derya Kaya, Ahmet Turan Işik

Turkish Journal of Medical Sciences

Background/aim: The Oral Frailty Index-8 (OFI-8) is a reliable screening for oral frailty. In our study, while presenting the Turkish reliability and validity study of the OFI-8, we also aimed to establish a cut-off value for oral frailty in Turkish population.

Materials and methods: Patients who presented to the outpatient clinic between January 2024 and January 2025 were evaluated. The test’s internal consistency and test–retest reliability were assessed. Divergent validity was evaluated using frailty scores, muscle strength, and nutritional status. A receiver operating characteristic (ROC) curve was generated to determine the optimal cut-off values for identifying frailty, malnutrition, and probable …

Preference Of Mechanical Ventilation Modes Among Intensivists In Türkiye: A National Wide, Point Prevalence Study, Süleyman Yildirim, Nurhayat Kilinç Özgün, Özcan Alpdoğan, Hüseyi̇n Uçar, İmren Taşkiran, Adnan Ata, Özhan Özcan, Kivanç Öncü, Saba Mukaddes Acarbay, Temel Güner, Pinar Özgün, Zerri̇n Özçeli̇k, Ayşegül Çinaroğlu, Gi̇zem Kurada, L. Serap Avlaği, Onur Gökçe, Özkul Yilmaz Çolak, Fatma Ülger, Melda İşevi̇, Özgür Kiliç, Rahi̇me Aydin Kayali, Meti̇n Yarici, Berkay Küçük, Fatma Yildirim, Kami̇l Gönderen, Bi̇şar Ergün, Kutlay Aydin, Kamuran Uluç, Sevda Onuk, Mi̇ne Altinkaya Çavuş, Yelda Balik, Ahmet Sari, Hayri̇ye Cankar Dal, Şeri̇fe Gökbulut Bektaş, Sema Turan, Ferhan Demi̇rer Aydemi̇r, Türkay Akbaş, Hamza Gülteki̇n, Kani̇ye Aydin, Seli̇n Eyüpoğlu, Havva Kocayi̇ği̇t, Gürhan Taşkin, Kazim Rollas, Mensure Çakirgöz, Cenk Kirakli

Turkish Journal of Medical Sciences

Background/aim: Invasive mechanical ventilation (IMV) is a fundamental intervention for patients with respiratory failure in intensive care units (ICUs). This nationwide, multicenter point-prevalence study aimed to describe current mechanical ventilation mode preferences (conventional, adaptive, and biphasic) in Turkish ICUs and to report associated clinical outcomes descriptively, without assessing causal relationships.

Materials and methods: A nationwide, multicenter point-prevalence study was conducted on 17 April 2024 and included adult patients (≥18 years) who had been receiving IMV for more than 24 h. Data on patient demographics, ventilation mode distribution, ventilatory parameters, and descriptive clinical outcomes on day 28 (weaning status, tracheostomy, and …

Retrospective Evaluation Of Treatment Outcomes Of Gasserian Ganglion Radiofrequency Thermocoagulation In Trigeminal Neuralgia Patients With Multiple Sclerosis, Emel Başar, Nevci̇han Şahutoğlu Bal, Erkan Yavuz Akçaboy

Turkish Journal of Medical Sciences

Background/aim: Trigeminal neuralgia (TN) secondary to multiple sclerosis (MS) is a rare but debilitating condition. Aside from two case reports, there are limited data on the use of Gasserian ganglion radiofrequency interventions in this patient population. This study aims to evaluate the outcomes of combined radiofrequency thermocoagulation (RFT) and pulsed radiofrequency (PRF) treatment targeting the Gasserian ganglion in patients with MS-related TN.

Materials and methods: We retrospectively analyzed 12 patients with MS-associated TN who underwent combined Gasserian ganglion RFT and PRF treatment between 1 January 2021 and 1 January 2025. Patients were followed for six months. Visual analog scale (VAS) …

Feeding Time Index And Mortality In Intensive Care Stroke Patients: An Exploratory Cohort Study, Nevzat Mehmet Mutlu, Duygu Karaköse Çalişkan, Tülay Tunçer Peker, Özlem Balkiz Soyal, Ayşe Pinar Ti̇ti̇z, Behi̇ye Deni̇z Kosovali, Göksal Günerhan, Büşra Tezcan

Turkish Journal of Medical Sciences

Background/aim: Stroke is a major cause of morbidity and mortality worldwide, with especially high mortality in intensive care unit (ICU) patients, whose prognosis is worsened by dysphagia, malnutrition, and aspiration risk. The Feeding Time Index (FTI)—defined as the ratio of feeding days to total ICU length of stay—quantified nutritional exposure. This exploratory cohort study aimed to evaluate the association between FTI and mortality in ICU patients with acute ischemic stroke (IS) or hemorrhagic stroke (HS) and to examine the potential role of FTI, together with the Acute Physiology and Chronic Health Evaluation II (APACHE II) score and oral feeding status, …

Inflammation As A Harbinger Of Death: A Retrospective Cohort Study Of Preoperative Biomarker Risk Stratification In Orthopedic Trauma, Serkan Aydin, Burhan Kurtuluş

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the prognostic significance of preoperative inflammatory markers including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), C-reactive protein (CRP), and procalcitonin in predicting 30-day and 1-year mortality in patients undergoing femur fracture surgery.

Materials and methods: This retrospective, multicenter cohort study included patients who underwent surgical treatment for femur fractures between January 2018 and December 2024. Patients were stratified into survivor and nonsurvivor groups based on 30-day and 1-year outcomes. Demographic characteristics, comorbidities, laboratory parameters, and inflammatory indices were recorded and analyzed. Linear and multivariate logistic regression analyses were performed to identify …

Preoperative Inflammatory And Molecular Marker Changes In 125 Supratentorial Glioma Cases, Semi̇h Can Çeti̇ntaş, Burak Tahmazoğlu, Tufan Agah Kartum, Rahşan Kemerdere, Taner Tanriverdi̇

Turkish Journal of Medical Sciences

Background/aim: To determine whether there is a possible link between selected preoperative systemic inflammatory markers and molecular pathological indices.Material and methods: For this retrospective study, 125 patients served as subjects. Preoperative systemic inflammatory markers, namely neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR), and postoperative pathological indices, namely mitosis, Ki-67 labeling index (LI), isocitrate dehydrogenase-1 (IDH1) mutation, and 1p/19q codeletion, were obtained from the electronic database.

Results: Results showed that NLR positively correlated with PLR (p = 0.00001), mitotic activity (p = 0.001), and Ki-67 LI (p = 0.00001). On the other …

Proximal Fragment Perfusion Following Hip Arthroplasty With Subtrochanteric Shortening Osteotomy In Patients With Severe Developmental Dysplasia Of The Hip, Vedat Bi̇çi̇ci̇, Hi̇lmi̇ Alkan, Enejd Vei̇zi̇, Şahan Güven, Serkan Ünlü, Eli̇f Özdemi̇r, Tural Talibli, Ahmet Firat

Turkish Journal of Medical Sciences

Background/aim: The changes in proximal femoral blood flow occurring after reconstructive surgery for Crowe types III– IV developmental dysplasia of the hip (DDH) and their impact on healing remain unclear. In the present study, blood flow around the osteotomy site is evaluated with particular focus on the proximal segment in patients who underwent subtrochanteric shortening osteotomy and hip arthroplasty. To this end, single-photon emission computed tomography (SPECT/CT) scans were conducted to evaluate changes in proximal blood flow and to assess the impact on union rates and potential complications.

Materials and methods: A retrospective analysis was conducted of 26 hips from …

Ultrasound-Guided Microwave Ablation For The Treatment Of Abdominal Wall Scar Endometriosis, Saffet Öztürk, Umut Asfuroğlu, Esi̇n Kurtuluş Öztürk, Sadik Ahmet Uyanik, Gülcan Kocaoğlu, İsmai̇l Burak Gülteki̇n, Hüseyi̇n Levent Keski̇n

Turkish Journal of Medical Sciences

Background/aim: To evaluate the efficacy of ultrasound (US)-guided microwave ablation (MWA) in treating abdominal wall endometriosis (AWE) lesions located at the cesarean scar and to assess the early clinical outcomes of this minimally invasive procedure.

Materials and methods: A total of 18 patients diagnosed with AWE based on characteristic clinical and US findings were included in this retrospective study. Preprocedural visual analog scale (VAS) scores, ultrasonographic features, and lesion volumes were recorded. The procedure was performed under both general and local anesthesia to ensure patient comfort and procedural accuracy. Hydrodissection was performed before ablation to minimize the risk of thermal …

Efficacy Of External Oblique Intercostal Plane Block In Postoperative Analgesia Following Laparoscopic Radical Nephrectomy, Gi̇zem Avci, Yusuf Özgüner, Damla Usalan, Cem Koray Çataroğlu, Habi̇p Yilmaz, Savaş Altinsoy, Jüli̇de Ergi̇l

Turkish Journal of Medical Sciences

Background/aim: The external oblique intercostal plane block (EOIB) is a regional anesthesia technique that may be utilized for the management of postoperative pain following laparoscopic radical nephrectomy. This study aims to evaluate the efficacy of EOIB after laparoscopic radical nephrectomy by comparing 24 h tramadol consumption between groups.

Materials and methods: Initially, 66 patients were enrolled in the study, and after exclusions, 60 were analyzed and divided into two groups: the EOIB group and the control group. Postoperative tramadol consumption, pain scores at rest and during movement, and dermatomal coverage of the block were recorded.

Results: The EOIB group (181.33 …

The Burden Of Knee Pain In The Operating Room: Are Surgical Personnel At Greater Risk?, Ömer Faruk Naldöven, Yavuz Karaman, Başak Si̇nem Sezgi̇n, Şahan Güven, Enejd Vei̇zi̇, İzzet Bi̇ngöl

Turkish Journal of Medical Sciences

Background/aim: This study aimed to determine the prevalence of knee pain among healthcare workers in surgical units and to explore whether the use of knee panels during surgical hand scrubbing is associated with persistent knee pain.

Materials and methods: This single-center cross-sectional study was conducted between October 2023 and March 2025. A total of 400 physicians and nurses working in surgical and nonsurgical departments were included. Participants completed a structured and modified Nordic Musculoskeletal Questionnaire, as well as knee pain assessment tools, including a visual analog scale (VAS) and the Kujala score for anterior knee pain-related symptoms. Occupational exposure among …

Etiologies Of Chronic Cough In Children: A Two-Year Experience From A Tertiary Pediatric Pulmonology Center, Yasi̇n Maruf Ergen, Nagehan Emi̇rali̇oğlu, Ebru Yalçin, Deni̇z Doğru, Uğur Özçeli̇k, Nural Ki̇per

Turkish Journal of Medical Sciences

Background/aim: Chronic cough is a common yet diagnostically challenging symptom in pediatric pulmonology. This study aimed to evaluate the etiologies of chronic cough in children referred to a tertiary center and to analyze the relationship between specific cough characteristics and final diagnoses.

Materials and methods: This retrospective study evaluated patients presenting with chronic cough (duration >4 weeks) at a tertiary pediatric pulmonology center. Demographic data, cough characteristics (wet vs. dry), and diagnostic findings were analyzed.

Results: A total of 62 patients were included. A specific etiology was identified in 95.1% of the patients. Asthma and reactive airway disease were the …

Clinical Features And Outcomes Of Childhood Interstitial Lung Disease: A Tertiary Center Experience, Ayyüce Ünlü, Şule Seli̇n Akyan Soydaş, Sati Özkan Tabakçi, Işil Bi̇lgi̇ç, Meltem Kürtül Çakar, Gamze Akca Di̇nç, Hande Yeti̇şgi̇n, Çelebi̇ Yildirim, Gökçen Di̇lşa Tuğcu, Di̇lber Ademhan Tural, Sanem Eryilmaz Polat, Güzi̇n Ci̇nel

Turkish Journal of Medical Sciences

Background/aim: Childhood interstitial lung diseases (chILD) constitute a rare and clinically complex group of disorders. This study aimed to characterize the clinical, radiological, and genetic features, as well as the outcomes, of chILD in a Turkish cohort classified according to the chILD-EU framework.

Materials and methods: We retrospectively reviewed the medical records of 84 pediatric patients diagnosed with chILD between 2017 and 2024 at a tertiary referral center in Türkiye. Patients were categorized according to the chILD-EU classification. Clinical variables, imaging findings, genetic analyses, pulmonary function test results, and Fan severity scores were systematically assessed. Logistic regression analysis was performed …

Fitness Cost And Biofilm Formation In Fosfomycin-Resistant Clinical Escherichia Coli And Klebsiella Pneumoniae Isolates, Mustafa Ökeer, Sabi̇re Şöhret Aydemi̇r, Bayri Eraç

Turkish Journal of Medical Sciences

Background/aim: Fosfomycin has regained importance owing to its unique mechanism of action and effectiveness against extended-spectrum β-lactamase-producing Gram-negative bacteria. This study aimed to evaluate the biological fitness cost associated with fosfomycin resistance and its impact on biofilm formation in clinical Enterobacteriaceae isolates.

Materials and methods: A total of 78 Escherichia coli and 34 Klebsiella pneumoniae strains isolated from urine samples at Ege University Hospital were analyzed. Fosfomycin minimum inhibitory concentrations (MICs) were determined using the reference agar dilution method. Resistance was induced by exposing two K. pneumoniae strains with a fosfomycin MIC of 4 μg/mL and two E. coli strains …

Nonclassical Philadelphia-Positive Fish Signal Patterns In Cml And Seven Cases With Variant Philadelphia, Sevgi̇ Işik, Oğuz Çi̇li̇ngi̇r, Gülçi̇n Günden, Fi̇li̇z Yavaşoğlu, Hülya Özen, Mert Burak Raşan, Beyhan Durak Aras

Turkish Journal of Medical Sciences

Background/aim: Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome (Ph), which occurs as a result of t(9;22). In 5%–10% of CML cases, variant t(9;22)s are observed. Additionally, while t(9;22) is formed, deletions can be observed in chromosomes 9 and 22. These deletions are observed more frequently in variant t(9;22). There is conflicting information in the literature about the prognostic effects of variant t(9;22) and deletions of 9q and 22q. There is also limited information about the frequency and breakpoints of other chromosomes involved in the variant t(9;22). Signal patterns other than the classical signal pattern of FISH analysis …

The Enigmatic Role Of The C-Reactive Protein And Albumin In Behcet’S Disease, Zohreh Jadali

Turkish Journal of Medical Sciences

No abstract provided.

Comment On “Survival Of Patients With 2014 Figo Stage Iiic High‑Grade Serous Ovarian Cancer Treated With Platinum‑Based Adjuvant Chemotherapy”, Abdullah Saad, Syeda Abeeha Hasan, Syeda Aki̇fa Sajid

Turkish Journal of Medical Sciences

No abstract provided.

Creating Healthy Work Environments For New Bsn-Dnp Students Through A Student-Led Mentorship Program, Daniel W. Martin, Christopher H. Connors, Jocelyn Keaton, Todd Tussing

Creating Healthy Work Environments (CHWE)

Background: Graduate students experience unique stressors that affect the decision to complete their programs. These include acclimation to the graduate school environment, coursework, and life balance. Attrition rates between 2006-2015 for DNP (Doctor of Nursing Practice) programs were 13.3-23.8% and 19.2% for BSN-DNP students with most dropping within 2 years. A possible solution to increased attrition could be to help decrease feelings of isolation and support student acclimation. Literature shows mentorship is an effective strategy for graduate nursing programs that results in decreased stress and anxiety, improvement in self-confidence, and improved adjustment to the educational environment. A student led peer …

Beyond "Place Matters": Making Spatial Analysis Accessible With Dashboard-Driven Geography, Stephen Borders

Public Health

This article presents an instructional module that uses Tableau to teach spatial thinking and policy geography through an analysis of Supplemental Nutrition Assistance Program (SNAP) participation. Tableau’s ability to integrate custom spatial files with demographic and health data makes it an accessible platform for introducing geographic inquiry without requiring specialized GIS expertise. The lesson guides instructors through building maps, bullet charts, and scatterplots that highlight gaps between eligibility and enrolment, while connecting food insecurity to health outcomes. By lowering technical barriers, Tableau provides a pedagogical bridge that helps educators foster spatial literacy in diverse classroom contexts.

This article was published …

Lindenwood Writers Receive Pushcart Prize Nominations, Lindenwood University

Archived Lindenwood Press Releases

No abstract provided.

Beyond Rationality: The Role Of Emotions In Communicative Planning, Minji Cho

Urban Studies and Planning Faculty Publications and Presentations

The impact of emotional dynamics has been overlooked within the field of planning. Traditional communicative planning theory, rooted in Habermas’ model of communication, typically propose that emotions should be managed to facilitate rational discussions that lead to logical agreements. Conversely, some research contends that emotions are not illogical or hazardous elements to be restrained during deliberation; instead, they are a topic requiring thorough investigation to create improved public forums. We investigate this tension by analysing facework during a land-use dispute at at the Gongjin Elementary School site in Seoul, South Korea. Our analysis reveals that facework not only impedes the …

Clinical Outcome Of Extremity Arterial Injuries In The Modern Era, Ali̇ Kuşsan, Selçuk Coşkun, Alp Şener, Ferhat İçme, Pinar Köksal Coşkun, Gülhan Kurtoğlu Çeli̇k

Turkish Journal of Medical Sciences

Background/aim: Extremity arterial injuries (EAIs) present a significant clinical challenge due to the risk of limb ischemia, amputation, and mortality. This retrospective cohort study aimed to delineate the clinical course, treatment strategies, and patient outcomes following trauma-induced EAIs, and to identify independent predictors of adverse outcomes.

Materials and methods: Retrospectively analyzed were data from 168 consecutive patients with traumatic EAIs who underwent computed tomography angiography at a tertiary care center between 2019 and 2025. Data extracted from electronic medical records included demographics, injury mechanisms, clinical presentation, laboratory findings, imaging results, treatment modalities (primary repair, grafting, endovascular intervention, conservative management), and …