Digital Commons Network^™

Ms-Based Workflow For Ptm Profiling Of Aav Capsid Proteins To Support Bioprocess Monitoring And Development, Patricia Alves, Mateus Tomás, Carvalho B. Sofia, Gomes-Alves Patrícia, Gomes A. Ricardo, Alexandre M. Bruno

Advancing Manufacture of Cell and Gene Therapies IX [2026]

Please click Additional Files below to see the full abstract

Gmp-Compatible Fluoropolymer Closed Culture Systems For Manufacturing And Controlled Aggregation Of Stem Cell-Derived Pancreatic Progenitors For Diabetes Cell Therapy, Praveen Pedabaliyarasimhuni, Balaji Ramachandran, Will Yoon, Demetry Prezelj, Lyne Khair, Nicolas Drolet, Katie Campbell, Corinne A Hoesli

Advancing Manufacture of Cell and Gene Therapies IX [2026]

Please click Additional Files below to see the full abstract

Cash Or Crash: Return To Player Percentages And Expected Value Of Crash Games, Robert H. Scott Iii, Mikhail M. Sher, Jonathan Daigle

UNLV Gaming Research & Review Journal

Crash games are a new type of casino game offered on some online gambling sites. The first crash game was created by the online cryptocurrency casino Bustabit. Other cryptocurrency casinos started offering their own versions of crash games. Now mainstream online casinos have developed their own crash games—notably Rocket by DraftKings. Crash games are easy to learn and play. They offer the opportunity to increase your bet by many hundreds of multiples—though, as we show when deriving expected values, these outcomes are rare. In this paper, we study the history of crash games and calculate theoretical values of crash game …

Mitigating Salmonella In Poultry Using Probiotics: Mechanisms, Challenges, And Opportunities, Oluwaseun D. Adeyemi, Samuel N. Nahashon

Food and Animal Sciences Faculty Research

The global poultry industry continues to face significant challenges due to Salmonella infections, which pose severe public health concerns and economic losses. Recently, the reemergence of antimicrobial resistance has led to the restriction of antibiotic use in poultry, especially as growth promoters, thus accelerating the search for sustainable alternatives. Among these, probiotics have gained attention as potential candidates for improving poultry health and mitigating Salmonella colonization in the gut. This review summarizes the key mechanisms through which probiotics exert anti-Salmonella effects, including competitive exclusion, production of antimicrobial substances, reinforcement of the intestinal barrier, and modulation of host immune responses. Commonly …

Funding Resilience Or Missing The Mark? An Analysis Of Rrf Allocation And Climate Risk Alignment In Italian Municipalities, Giulio Breglia, Mariagrazia D’Angeli, Giacomo Gazzellone

Fondazione Eni Enrico Mattei Working Papers

Natural hazards are an increasing concern, placing disaster preparedness and mitigation at the forefront of policy agendas. In this context, Italy’s Recovery and Resilience Plan (NRRP) has allocated €3 billion for explicit disaster prevention, with a primary focus on hydrogeological risks such as floods and landslides. This study evaluates the geographical and thematic distribution of resilience-related funding, examining whether financial resources have been effectively targeted toward municipalities with the highest exposure to environmental hazards. Using a clustering classification, we identify substantial disparities in the allocation of resilience funds, revealing that municipalities with relatively low risk levels often receive disproportionately high …

Development Of An Aav-Based Gene Therapy For The Ocular Phenotype Of Friedreich's Ataxia., Heyu Tang, Siddhant Gupte, Emily Xu, Kaitlyn R Calabro, Hannah Friend, Sean M Crosson, Diego Fajardo, Zachary Kostamo, Hangning Zhang, James J Peterson, Fangyu Lin, Zbynek Kozmik, Cathleen Lutz, Sanford L Boye, Shannon E Boye

Faculty Research 2026

Friedreich's ataxia (FA) is a leading form of hereditary ataxia caused by autosomal recessive mutations in frataxin (FXN). GAA triplet repeat expansions lead to lower levels of FXN expression, abnormal influx of iron into mitochondria, and damage to the nervous system. Patients typically present before the second decade with loss of muscular function, speech impediments, and cardiomyopathy. At later stages, vision loss typically manifests. Work is under way to develop gene therapies that address the cardiac and CNS manifestations, but their routes of administration do not lead to efficient transduction of the retina. The purpose of this study was to …

Development Of An Aav-Based Gene Therapy For The Ocular Phenotype Of Friedreich's Ataxia., Heyu Tang, Siddhant Gupte, Emily Xu, Kaitlyn R Calabro, Hannah Friend, Sean M Crosson, Diego Fajardo, Zachary Kostamo, Hangning Zhang, James J Peterson, Fangyu Lin, Zbynek Kozmik, Cathleen Lutz, Sanford L Boye, Shannon E Boye

Faculty Research 2026

Friedreich's ataxia (FA) is a leading form of hereditary ataxia caused by autosomal recessive mutations in frataxin (FXN). GAA triplet repeat expansions lead to lower levels of FXN expression, abnormal influx of iron into mitochondria, and damage to the nervous system. Patients typically present before the second decade with loss of muscular function, speech impediments, and cardiomyopathy. At later stages, vision loss typically manifests. Work is under way to develop gene therapies that address the cardiac and CNS manifestations, but their routes of administration do not lead to efficient transduction of the retina. The purpose of this study was to …

A Case Of Dislocation And Successful Reduction Of A Right Anterior Shoulder Inside A Space Suit: Considerations For Future Protocols, Samuel Beger, Curtis Lowery, Nicolas Heft, Amran Asadi, Brandon Trapp, Jaime Mateus, Alejandro Garbino

Faculty, Staff and Student Publications

Shoulder dislocations are prevalent on Earth and pose unique challenges in spaceflight and spaceflight training, particularly during extravehicular activities (EVAs). This case report describes a 50-year-old male who experienced an anterior shoulder dislocation while performing an emergency egress exercise in a SpaceX EVA suit. The report describes the medical thought process, the operational constraints, and the reduction techniques employed to achieve a successful shoulder reduction without fully removing or damaging the suit. NASA estimates a high likelihood of shoulder injuries during long-duration lunar missions, emphasizing the importance of suit designs and rescue protocols. Quick and effective medical intervention is crucial, …

On The Need Of Pluralism And Common Ground In Sla, Simona Pekarek Doehler, Steven L. Thorne, Soren W. Eskildsen, Marije C. Michel

World Languages and Literatures Faculty Publications and Presentations

Hyperbolic claims that SLA is in crisis (!), that a unifying theory is overdue, or that research must be oriented toward pedagogy have resurfaced once again—most recently in the response by Lantolf et al. (2025) to the Special Issue on Synergies in Second Language Acquisition and Teaching (SLA/T) (Atkinson et al., 2025). Our own position is diametrically opposed to such claims.

Theoretical And Conceptual Approaches To Journalism Education, August E. Grant, Jeffrey S. Wilkinson, G. Nathan Carnes

Faculty Publications

Many journalism programs embrace the teaching hospital model because of its practical approach, employing working journalists as journalism educators. However, critics contend a more conceptual model of journalism education is needed. This essay explores the literature on journalism education models and seeks to integrate the teaching hospital and entrepreneurial journalism approaches with the revised Bloom's Taxonomy and Fink's Taxonomy of Significant Learning. Combined, these models provide a solid theoretical foundation for practical, applied journalism education. This essay applies these four models to journalism education, yielding a matrix of dimensions that can guide the creation or modification of curricula as well …

Competitive Advantage Strategies For Independent Restaurant Owners, Bobby Mccrary

Walden Dissertations and Doctoral Studies

Independent restaurant owners often face challenges in achieving a sustainable competitive advantage, resulting in poor business performance and loss of profitability. Identifying practical competitive advantage strategies is essential for independent restaurant owners to surpass five years of business operations. Grounded in resource-based view theory, the purpose of this multiple case study was to explore effective competitive advantage strategies independent restaurant owners used to sustain operations beyond five years. Purposeful sampling was used to select four independent restaurant owners located in Wichita, Kansas, who sustained operations beyond five years through competitive advantage strategies. Data were collected from semistructured interviews and from …

Multimodal Education To Improve Metabolic Monitoring Knowledge Among Psychiatric Nurse Practitioners, Tania Alfonso

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) staff education project was a multimodal educational intervention to improve outpatient psychiatric nurse practitioner (PNP) knowledge of metabolic monitoring guidelines for patients prescribed second-generation antipsychotics (SGAs). The project addressed low adherence to national monitoring standards that contribute to increased cardiometabolic risks associated with SGAs. The project question was: Does staff education regarding metabolic monitoring guidelines improve nursing knowledge as compared pre- to posteducation? The purpose was to enhance PNP knowledge of metabolic monitoring guidelines. Guided by the Johns Hopkins evidence-based practice (JHEBP) model, I conducted a focused literature search and identified 28 peer-reviewed articles …

Key Strategies To Entrepreneurial Sustainability In The Information And Communications Industry, Agabi Godwin Onugba

Walden Dissertations and Doctoral Studies

Many businesses in the information and communications industry fail within the first 5 years, yet the existing empirical research has not sufficiently explained how surviving businesses achieve long-term sustainability. Startup business leaders are concerned about the high failure rate and the lack of evidence-based strategies that support sustained operations beyond 5 years. Grounded in Porter’s five forces theory, the purpose of this qualitative pragmatic inquiry project was to identify and explore successful strategies that information and communications industry startup business leaders use for long-term business sustainability beyond 5 years. Purposeful sampling was employed to select six startup leaders in the …

Staff Education Project To Improve Hypertension Medication Adherence In An Underserved Clinic, Margaret Mboe Etukeni

Walden Dissertations and Doctoral Studies

Hypertension is one of the most common chronic conditions managed in primary care. The identified practice problem for this staff education project was the lack of structured staff training and inconsistent provider knowledge regarding evidence-based strategies to improve medication adherence among patients with hypertension. Poor medication contributes to preventable complications such as stroke, heart failure, and kidney disease. The purpose was to evaluate if an educational intervention could improve provider knowledge related to medication adherence strategies in an underserved clinical setting. The practice question guiding the project was: In clinical staff working in an underserved clinic, does a staff education …

Perceptions Of Community College Faculty Regarding Online Student Engagement Challenges And Recommendations, Jana Allen-Bishop

Walden Dissertations and Doctoral Studies

The problem addressed through this study is that local community college faculty members struggle to develop student engagement in online courses. The purpose of this basic qualitative study was to explore community college faculty perceptions about challenges with student engagement in online courses and recommendations for fostering that engagement. The conceptual frameworks for this study were Knowles’ theory of andragogy and self-directed learning, as well as Mezirow’s transformative learning theory. Data were collected through semistructured interviews with eight community college faculty members teaching online courses. Through open and axial coding the following themes emerged: faculty noted that their own technological …

The Lumberjack, February 04, 2026

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Efficiency, Concentration, And Diversification: Portfolio Lessons From Indian Technology Equities, Davinder K. Malhotra, Shaurya Batra, Rahul Singh

School of Business Faculty Papers

This study examines the extent to which Indian technology equities generate sufficient returns relative to their inherent volatility and assesses whether intra-sector diversification can improve outcomes in this dynamic, high-risk sector. Drawing on data from January 2020 to April 2025, ten leading firms are analyzed using an integrated approach that incorporates traditional risk-adjusted indicators, downside-sensitive metrics, and a six-factor model featuring momentum. The results show clear heterogeneity in performance. Mid-cap innovators such as Persistent Systems and Coforge deliver positive and, in some cases, statistically significant alphas, while large-cap stocks including Infosys, Tata Consultancy Services (TCS), and Wipro provide stability but …

The Bg News February 04, 2026, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 04, 2026. Volume 105-Issue 16.

The Parthenon, February 04, 2026, Baylee Parsons, Kaitlyn Fleming, Abby Ayes, Ella Hatfield, Davina Synder, Scott Price, Lilli Ross, Trista Honaker

The Parthenon

No abstract provided.

Control-By-Interconnection Beyond Casimirs And Connections To Ida-Pbc, Joel Ferguson, Pablo Borja

School of Engineering, Computing and Mathematics

Control by Interconnection (CbI) and Interconnection and Damping Assignment Passivity-Based Control (IDA-PBC) are two nonlinear design methodologies that exploit passivity to construct stabilising controllers. While CbI is known to be a subset of IDA-PBC, the converse link has remained open. This paper revisits CbI by utilising dynamic invariants beyond Casimirs and a more general control structure. Using this more general structure we show a one-to-one correspondence between IDA-PBC and CbI controllers for the class of mechanical systems without friction.

New Host And Distributional Records For Helminth Parasites (Monogenoidea, Trematoda, Cestoda, Nematoda) Of Arkansas Reptiles (Testudines, Ophidia), C. T. Mcallister, C. R. Bursey, T. J. Fayton, S. E. Trauth, H. W. Robison

Journal of the Arkansas Academy of Science

Over the last decade or more, our collaborative research has provided noteworthy information on the helminth parasites of reptiles of Arkansas. Because several species still need to be surveyed from the state, some for the first time, there has been a general void of information on their parasites. We therefore examined 10 reptiles, including seven species/subspecies of turtles, as well as three species/subspecies of snakes for helminth parasites. Found were 24 taxa of parasites, including two monogeneans, 14 digeneans, one tapeworm, and seven nematodes. We document several new host and distributional records for these parasites from some reptiles of the …

The Heart’S Hidden Influencer: Epicardial Adipose Tissue In The Pathogenesis Of Heart Failure, Aobo Li, Avilash Mondal, Jianli Zhao, John Zhang, Xin-Liang Ma

Department of Emergency Medicine Faculty Papers

Abstract – Heart failure (HF) is a complex, multifactorial clinical syndrome with diverse etiologies and phenotypic manifestations, affecting millions of people globally. HF is broadly classified into 3 subtypes: HF with reduced ejection fraction, HF with mildly reduced ejection fraction, and HF with preserved ejection fraction. Each subtype exhibits distinct pathophysiological mechanisms, clinical trajectories, and therapeutic responses, posing significant challenges in terms of diagnosis and management. Epicardial adipose tissue (EAT), a metabolically active visceral fat depot situated in close proximity to the myocardium, plays a dual role in physiological and pathological states, offering potential utility as a biomarker and therapeutic …

Staff Education To Clinical Staff Within An Outpatient Psychiatric Practice, Ivy Dzifa Dzivenu

Walden Dissertations and Doctoral Studies

No abstract provided.

Improving Follow-Up And Continuity Of Care Protocols Through Staff Education In An Outpatient Mental Health Clinic, Bimpe Omobolade Adedo

Walden Dissertations and Doctoral Studies

In this DNP staff education project, I aimed to solve two main issues which disrupted patient treatment continuity: better documentation and follow-up care practices. The existing gaps in knowledge have led to missing scheduled appointments, missing medical information, and weak communication between hospital staff and clinic staff resulting in disorganized patient care. The main goal of the project was to improve staff understanding of post treatment procedures, maintenance systems, and medical recordkeeping requirements. Ten clinical staff members participated in education. Pre- and post-knowledge assessments were used to evaluate knowledge change. The normalized learning gain formula served to measure the extent …

Agricultural Water Management In A Changing Maryland: Stakeholder Experiences And Attitudes Towards Weather Variability, Alternative Water Sources, And Related Factors, Michele Romolini, Alexa C. Siglar, Paul T. Leisnham, Amanda K. Rockler, Masoud Negahban-Azar, Adel Shirmohammadi

Center for Urban Resilience Scholarship

The state of Maryland has experienced significant but commonly overlooked impacts on water quality and quantity. Future climate change is predicted to further reduce water availability, with nontraditional water sources such as treated recycled wastewater (TRW) as one potential way to mitigate impacts. We conducted semi-structured interviews with 17 Maryland stakeholders—including farmers, extension agents, state agency personnel, and academics—to explore their perceptions and experiences with 1) past, existing and future weather variability; 2) freshwater and reusable water use and management in agriculture; and 3) related factors impacting agricultural water management. Qualitative coding of interview transcripts produced 27 categories containing 291 …

Gene Regulatory Programs Of Nk Cells Show That Ncam1 (Cd56) And Kirs Are Controlled By Genetically Polymorphic Distal Regulatory Elements, Mariam A. Salem, Aditi Varkey, Matthew D. Estrada, Kruthika Sharma, Caprice D. Eisele, Nitin Chakravarti, Dean A. Lee, Aharon G. Freud, Bethany L. Mundy-Bosse, Patrick L. Collins

Kimmel Cancer Center Faculty Papers

Owing to their immunoprotective properties, natural killer (NK) cells are critical for the innate immune response to pathogens, as well as a new wave of cancer immunotherapy that harnesses natural cytotoxicity. We sought to study the genetic and epigenetic drivers behind human-specific NK cell receptors, so that we can better understand the underlying cellular function. Here, we present a transcriptomic, proteomic (CITE-seq), and chromatin (single nuclei ATAC-seq) profiling of human peripheral NK cell subsets, which was then compared with genomic databases. Through integrative multi-omics, we demonstrate that CD56^bright versus CD56^dim NK cell subsets have differential distal regulatory element …

Job Stress, Emotional Exhaustion, And Work-Family Conflict: A Moderated Mediation Model, Sina Eslamdoust, Jeeyoon Jeong, Ji Hoon Lee, Ye Dai

Business Analytics Faculty Publications

Despite extensive research on work-family conflict (WFC), questions remain about when and why job stress translates into family domain interference. Drawing on Conservation of Resources (COR) theory (Hobfoll, 1989), this study examines whether emotional exhaustion mediates the relationship between job stress and WFC, and whether authoritarian leadership moderates this process. Using data from 1,095 U.S. employees, we find that emotional exhaustion serves as a key mediating mechanism, consistent with resource depletion arguments. More importantly, we demonstrate that authoritarian leadership significantly amplifies the stress-exhaustion relationship through mechanisms identified in prior research: reduced autonomy, increased monitoring, and blocked recovery. These findings extend …

Passed Down Like Prayer: The Burden And Inheritance Of The Superwoman Schema, Keyishi Shante Peters

Tennessee State University Alumni Theses and Dissertations

This qualitative phenomenological study examined how Black Baby Boomer and Millennial women perceive and internalize the Superwoman Schema (SWS), a cultural expectation emphasizing strength, emotional restraint, and self-sacrifice. Grounded in Black feminist thought, the analysis explored how the SWS is passed down like prayer, quietly inherited, spiritually charged, and embedded in the everyday practices of survival. Four themes emerged: Being Everything to Everybody, Carrying It All Until It Breaks You, We Were Taught Not to Say No, and Learning to Put the Cape Down. Baby Boomers often described the SWS as a necessary legacy forged through historical struggle, while Millennials …

Prevention, Consultation, And Advocacy, Terrance Mcclellan

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Goal Statement

My goal is to prevent depression among single mothers ages 20–30 in low-income areas of Southeast Missouri by expanding access to community-based emotional support, parenting resources, and skills training that strengthen coping and resilience.

Significant Findings

Young single mothers in Southeast Missouri, especially those in their twenties, often carry the emotional and financial weight of raising children on their own, which puts them at higher risk for long-term stress and depression when support is limited (Tafet & Nemeroff, 2016; NAMI Missouri, 2025). Many face persistent barriers such as high childcare costs, reduced access to mental health providers, transportation …

Doctrinal Intent Versus Institutional Reality: The Gulf Countries' Antitrust Objectives, Nora Memeti

Yearbook of Antitrust and Regulatory Studies

This paper examines the intriguing contrast between the ambitious goals of antitrust laws in the Gulf countries and the reality of their enforcement. While this region seeks to protect competition and curb monopolistic practices, only Kuwait and the Kingdom of Saudi Arabia (KSA) have made significant strides in achieving these ideals.

Through a comparative legal analysis, this paper examines how the statutory objectives of competition law in Qatar, Bahrain, Oman, and the UAE often remain more rhetorical than substantive, with enforcement primarily symbolic. In contrast, Saudi Arabia demonstrates some enforcement activity, although its alignment with legislative objectives remains uncertain. Kuwait's …