Digital Commons Network^™

Impact Of Type 2 Diabetes Mellitus Without Retinopathy On Longitudinal Oct And Visual Field Changes In Primary Open-Angle Glaucoma, Amer Ahmed, Deena Shefter, Fabio Lavinsky, Ronald Zambrano, Qiang (Ed) Zhang, Dilru Amarasekera, Lauren E. Hock, Ping Huang, Natasha Kolomeyer, Reza Razeghinejad, Jonathan S. Myers, Gadi Wollstein, Joel S. Schuman

Phase 1

Introduction/Purpose: Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness, and diabetes mellitus (DM) is common in this population. However, the effect of DM without diabetic retinopathy (DR) on glaucoma progression is unclear. We evaluated whether structural and functional progression differ between POAG eyes with DM, but no DR, and age- and visual field (VF) mean deviation (MD)-matched non-diabetic POAG eyes.

Methods: We conducted a retrospective longitudinal study at three academic centers comparing POAG+DM (no DR) with POAG-only eyes. Eligibility required ≥3 qualified OCT scans and ≥3 reliable VFs over ≥1 year; eyes with DR or other major …

Age-Related Challenges Of Blood Pressure Management In Patients With Spinal Cord Injury, Brian Frost, Maclain Capron, Michael Stillman

Phase 1

Introduction/Purpose: Autonomic dysreflexia (AD), orthostatic hypotension (OH), and postprandial hypotension (PPH) are forms of dysautonomia that can affect people with spinal cord injury (SCI). Life expectancy for individuals with SCI has increased in recent decades, so it is critical to understand how triggers of these conditions change throughout the lifespan. This study will answer the question “What challenges do patients with SCI face regarding autonomic dysfunction as they age, and what are their perceptions of these challenges?”

Methods: This survey-based study aims to better understand dysautonomia in order to educate the medical community about specific challenges of growing older with …

Pre-Infusion Evaluation Of Pain In Children And Adults With Osteogenesis Imperfecta (Oi) Receiving Cyclic Pamidronate, Andrew Stolfe, Cristina Mcgreal, Sarah Little, Shannon Bonner, Ricki Carroll, Mahim Jain

Phase 1

Introduction/Purpose: Chronic pain is common in OI patients, but standardized pain assessment and treatment is lacking. Pamidronate, a bisphosphonate traditionally administered to OI patients to increase bone mineral density, could play a role in pain management. This study will describe baseline pain before receiving pamidronate to contribute to the characterization of pain in OI and justify the need for evaluating the impact of pamidronate on pain over time.

Methods: 54 patients with mild to severe OI were selected from the Nemours Skeletal Dysplasia Program (mean age 10.5±6.6 years [range 2-31 years]; 54% male, 46% female). Pain was assessed using the …

Cardiovascular Outcomes In Smoking And Nonsmoking Psoriasis Patients On Low- And Moderate-Intensity Statin Therapy, Eliana Khojasteh, Mahaa Ayub, Julianne Bartz, Matthew Keller, Md

Phase 1

Introduction: Psoriasis is associated with increased cardiovascular risk, and smoking amplifies this burden by worsening cardiovascular outcomes and psoriasis severity. Statins are the cornerstone of cardiovascular risk reduction; however, their lipid-lowering effectiveness in psoriasis patients across smoking statuses remains incompletely understood. This study evaluated whether smoking status influences LDL-C before and after statin initiation in adults with psoriasis.

Methods: We conducted a retrospective chart review of adults with psoriasis treated at Thomas Jefferson University Hospital between 2014 and 2024 who were prescribed low- or moderate-intensity statins. Data collected included smoking status (current vs. former/never) and LDL-C values before and at …

Spartan Daily, February 11, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 9

Nonenzymatic Glucose Biosensor Based On Selective Reduction Of Silver Ions, Maryam Sarlak, Shankar B. Rananavare

Chemistry Faculty Publications and Presentations

A nonenzymatic conductivity-based glucose biosensor, reported here, designed for potential noninvasive measurement in accessible biofluids such as saliva, sweat, and tears. The sensor exploits a classic Tollens’ silvering process that deposits metallic silver on a sensitized surface via a quantitative, selective reduction of silver ions by glucose. Of the two surface sensitization methods used, the self-assembled bifunctional thiol/silane surfactant yields a more stable and sensitive sensor than tin(II) chloride. The conductometric sensor consists of two spiral interdigitated silver electrodes fabricated by lithography and wet etching. The sensor impedance changes after selective metallic silver deposition between the electrodes. The sensor exhibits …

Three-Dimensional Versus Two-Dimensional Echocardiographic Assessment Of Left Atrial Volume And Deformation In Children, Alexander J Kiener, James Croft, Krista N Harris, Ankona Banerjee, Aura A Sanchez, Xander H T Wehrens, Anitha Parthiban, Xiaotian Gao, Tam T Doan, Minh B Nguyen

Faculty, Staff and Students Publications

Background: Left atrial (LA) volume and function are important for assessing pediatric diastolic dysfunction (DD). Three-dimensional echocardiographic (3DE) LA assessment may overcome limitations and assumptions inherent in two-dimensional echocardiographic (2DE).

Methods: We conducted a cross-sectional study of children under 18 years of age with structurally normal hearts, using transthoracic 3DE apical volume datasets. LA volumetric function and phasic deformation analyses were performed using 3DE (GE, EchoPAC 4DLAQ v206, near fully-automated) and 2DE (TomTec, TTA2.51, CPA, manual) was performed by three operators and processing time was collected. Agreement and reproducibility was assessment for each modality.

Results: Fifty patients (median age 12.8 …

The History Of Mythlore, Janet Croft

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

A PLAN TO PUBLISH A JOURNAL representing the interests of the members of The Mythopoeic Society was announced in 1968 by the late Glen GoodKnight, who founded the society in 1967.

Patient Characteristics Associated With Telehealth Use In A Large Federally Qualified Health Center, Priyanka Gautom, Cara L. Eckhardt, Lisa K. Marriott, Cirila Estela Vasquez Guzman, Gloria D. Coronado

OHSU-PSU School of Public Health Faculty Publications and Presentations

The COVID-19 pandemic rapidly expanded telehealth services when in-person care was limited. Using primary care data from a large federally qualified health center in Washington state, this study aimed to: 1) describe trends in telehealth use among adult patients, and 2) provide disaggregated patient characteristic data associated with telehealth use, with a focus on patients speaking Asian Indian languages.

North Dakota Emergency Medical Personnel’S Perceptions Of Human Trafficking, Jessica Evans

Walden Dissertations and Doctoral Studies

Human trafficking is an abhorrent human rights violation, and victims experience a myriad of health disturbances while being exploited. Victims often seek emergency medical care, but research consistently shows that emergency medical personnel (EMP) are largely unprepared to screen, identify, and respond to them. However, there has been no research exploring their preparedness to screen, identify, and respond to victims of human trafficking, the barriers and challenges to identification of human trafficking victims, and training needs to improve screening, identification, and response to human trafficking victims in North Dakota. This study employed a generic qualitative approach grounded in constructivism. The …

The Moderating Role Of Self-Esteem In The Relationship Between Perceived Gender Bias And Job Satisfaction Among Women In The Technology Industry, Roberta L. Minicola

Walden Dissertations and Doctoral Studies

Women employed in the technology industry continue to experience gender-based bias that may adversely affect job satisfaction. Although the deleterious impact of gender bias on women’s job satisfaction has been well documented, the potential of self-esteem to mitigate this impact has not yet been examined. Informed by social dominance theory, the purpose of this quantitative, cross-sectional, correlational study was to examine the moderating effect of self-esteem on the relationship between perceived gender bias (i.e., insufficient support, devaluation, hostility) and job satisfaction among women working in the U.S. technology sector. Data were collected from 138 female technology professionals recruited through Amazon …

Mythlore Issue Checklist, Janet Croft

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Mythlore Issue Checklist

Tolkien Journal Issue Checklist, Janet Croft

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Tolkien Journal Issue Checklist

Phase 1 Open-Label Study Of Asp9801, An Oncolytic Virus, In Patients With Advanced Or Metastatic Solid Tumors, John L. Villano, Jason J. Luke, Ricklie Julian, Christos Fountzilas, Manish R. Patel, Michael J. Chisamore, Pranob Bhattacharya, Shigeru Takeshita, Serguei Soukharev, Shunsuke Yamada, Leshi Zhang, Kristopher P. Wentzel

Neurology Faculty Publications

Purpose ASP9801, an oncolytic virus encoding interleukin-7 and interleukin-12, was assessed for safety, tolerability, pharmacokinetics, and antitumor activity in patients with advanced solid tumors in a Phase 1 study. Methods The study comprised Part 1 ASP9801 monotherapy dose escalation and Part 2 dose expansion with ASP9801 monotherapy or plus pembrolizumab. Each part was divided into Groups A (ASP9801 injection into cutaneous/subcutaneous lesions) and B (ASP9801 injection into visceral lesions). Primary objectives were safety and maximum tolerated dose and/or recommended Phase 2 dose expansion (RP2D); secondary objectives included antitumor activity and pharmacokinetics. Results In dose escalation, 17 and 10 patients in …

Commonwealth Times 2026-02-11

Commonwealth Times, 1969-

No abstract provided.

Utility Of Neurosurgery-Specific Rag-Llm In Accurate Patient Outcome Prediction, Alexander Hone, Basel Musmar, Joanna Roy, Pascal Jabbour

Phase 1

Large Language Models (LLMs) have been previously utilized in the medical field to successfully generate information. However, LLMs may hallucinate, which generates a response based on false or misleading information. This can negatively impact healthcare outcomes, thus, there is an increasing need to develop a model free of hallucinations.

A multi-target voting ensemble (Random Forest with HistGradientBoosting) algorithm was utilized in the analysis of 454 training data and 114 test data. Raw accuracy and macro-F1 statistics determined that the model is capable of identifying clinically meaningful data for majority classes, while minority-class detection was insignificant. This demonstrates moderate predictive value …

Comparative Analysis Of Demographic Data For Eligible Lifestyle Medicine Program Participants, Cajetan Ejianreh, Amy Cunningham

Phase 1

Introduction: Obesity is a major comorbidity linked to a myriad of health complications and poor treatment outcomes. Through partnership with the PCORI Institute, a comprehensive lifestyle medicine program is being developed to refer eligible patients within the Jefferson Health System. This comparative analysis aims to identify the demographics of these eligible patients.

Methods: Data was extracted from EPIC electronic health record from patients who had a “qualifying” encounter with one of the following specialties: OB/GYN, Geriatrics, Internal Medicine, and Family Medicine. Qualification of patients in this data collection was based on an encounter with one of the aforementioned specialties within …

Patient Experiences With Provision Of Telehealth Addiction Treatment Services, Kaleigh Spollen, Shane Nieves, Mph, Gregory Jaffe, Md, Msed, Vanessa Short, Phd, Mph

Phase 1

Introduction: Substance use disorder (SUD) is a nationwide public health crisis, and deaths from opioids have risen significantly since 1999. In recent years, telehealth has emerged as a novel modality for SUD treatment. This study aims to evaluate patient experiences with a telehealth program for SUD, identifying barriers and facilitators to participation in the program, as well as opportunities for program improvement.

Methods: This qualitative study comprises an online survey and semi-structured interview. Individuals 18 years of age or older who have attended at least one session of Jefferson’s telemedicine program for SUD treatment were enrolled in the …

Cardiovascular Outcomes Of Youth Female Athletes: Stratifications Of Risk Using Subdivisions In Sports, Jillian D'Souza, Nikta Nair, David Shipon, Md

Phase 1

Introduction: Sudden cardiac death (SCD) in youth athletes is a rare, but devastating event that may proactively be prevented through identification of pathologic structural, functional and electrical cardiac remodeling changes. Pathological changes in female athletes along with the associated risk and protective factors related to SCD are understudied. This study aims to identify pathological cardiac changes in female athletes and inquire whether strength-based versus endurance-based sports carry different levels of risk.

Methods: The HeartBytes database was compiled from cardiac screenings of youth athletes in Southeastern Pennsylvania conducted from 2014 to 2021. Screenings collected information from health questionnaires, physical …

Leveraging Social Media To Disseminate Evidence-Based Messaging About Substance Use To Reduce Stigma And Promote Harm Reduction In Adolescents And Young Adults, Jacob Mihalic, Gregory Jaffe, Md, Msed

Phase 1

Introduction

Substance use disorder (SUD) remains a major contributor to morbidity and mortality in Philadelphia, with adolescents and young adults (AYAs) particularly vulnerable due to peer influence and digital exposure. However, harm reduction messaging rarely targets AYAs directly. This project will explore how AYAs engage with social media, how these platforms shape their perceptions of SUD, and how digital messaging can be leveraged to reduce stigma and support prevention.

Methods

This qualitative project will conduct three focus groups with Philadelphia AYAs aged 13-18, recruited through local Boys and Girls Clubs. Discussions will explore how AYAs engage with SUD-related content online, …

Designing A Multilingual Instructional Language Tool For Patient Communication In Interventional Radiology, Ahlam Houssein, Samuel Almodóvar, Gregg Khodorov, Md, Mba, Sahib Sohal, Md, Robert Pugliese, Pharmd, David Dwyer, Md

Phase 1

Introduction: Language barriers in healthcare contribute to medical errors, reduced patient adherence, and increased procedural risk among patients with limited English proficiency (LEP), particularly in interventional radiology (IR), where real-time verbal instruction is essential for procedural success. Current virtual translation services lack the immediacy, specificity, and workflow integration required for intraprocedural communication. This project asks how a digital platform can enable IR professionals to communicate procedural instructions to LEP patients accurately and efficiently in real time, hypothesizing that a structured, phrase-based translation system will improve procedural efficiency and safety.

Methods: On-site interviews and workflow observations were conducted with IR physicians, …

Improving Options For Prehospital Management Of Hyperthermia, David Azizi, Connor Coyle, Robert Pugliese, Pharmd

Phase 1

Introduction: Hyperthermia, particularly heatstroke, is a life-threatening failure of thermoregulation that requires rapid cooling to prevent serious sequelae. Despite effective hospital-based systems, prehospital and austere environments lack portable solutions capable of achieving timely temperature reduction. This project investigates whether a lightweight, field-ready garment incorporating endothermic salts can improve prehospital hyperthermia management.

Methods: We conducted a literature review and expert interviews with emergency and wilderness medicine clinicians to identify limitations of existing tools and define design requirements. A prototype was designed with a thermally conductive inner layer and insulating outer layer integrating off-the-shelf chemical cold packs. Planned testing includes quantifying heat …

Temperature Control Vest For Use In Acute Hyperthermic Episodes, Connor Coyle, David Azizi, Isaac Kravatz, Robert Pugliese, Pharmd

Phase 1

Introduction: In the acute treatment of acute hyperthermia that is treated in austere conditions, there is a lack of a portable, effective, and inexpensive device that can rapidly lower the temperature of the patient back to baseline levels. With rapidly rising global temperatures, we anticipate an increase in acute heat strokes where correction by cooling can save countless lives. We want to create a medical device that is effective in cooling a patient with hyperthermia to increase survival and recovery outcomes. Our main inquiry is whether it is reasonable to design, produce, and test a cooling device that fits within …

Auravena, Isaac Kravatz, Bassem Fayek, Robert Pugliese, Pharmd

Phase 1

Introduction: Over 200 million peripheral IVs are placed annually, serving as critical access points for medications and therapies, yet up to 40% fail on the first attempt. While heat is often used to support IV placement, current methods are insufficient compared to what the literature suggests. Therefore, we asked: how might heat be applied more efficiently and sustainably to improve first-attempt success rates for patients with difficult IV access?

Methods: We began by interviewing nursing staff at an outpatient infusion center, uncovering a significant gap in care for patients with difficult IV access. These insights drove iterative design cycles focused …

Impact Of Jackson-Pratt Drain Placement Location On Postoperative Pain In Breast Mastectomy And Reconstruction, Spencer Haber, Bs, Elizabeth Simon, Bs, Krishna Koka, Bs, Devin Williams, Bs, Andrew Newman, Md

Phase 1

Introduction: The Jackson-Pratt (JP) drain is routinely used after breast mastectomy and reconstruction. However, postoperative JP drain usage is associated with an increased incidence of surgical site pain (SSP), which negatively impacts quality of life (QOL). We hypothesize that the anatomical site of JP drain placement relative to major nerve densities leads to variation in SSP and QOL.

Methods: This prospective cohort study will enroll 30 adult female patients undergoing breast mastectomy or reconstruction. Drain placement location will be measured intraoperatively using X, Y coordinates based on midline, anterior axillary line, and jugular notch landmarks. Normalized spatial data will be …

The Correlation Between Pain And Placement Of The Jackson-Pratt Drain In Post-Mastectomy Patients, Krishna Koka, Bs, Elizabeth Simon, Bs, Spencer Haber, Bs, Devin Williams, Bs, Andrew Newman, Md

Phase 1

Introduction

The Jackson-Pratt Drain is a frequently used closed-suction, active drain system that prevents seroma and hematoma formation through negative pressure drainage. Prior research has revealed that some patients report increased surgical site pain that negatively impacts quality of life. We hypothesize that interpatient variability in pain may be associated with the location of drain placement relative to local innervation.

Methods

We are targeting 30 biologically female patients >30 years old undergoing bilateral mastectomy, excluding those with factors affecting chest wall innervation. Drain placement was measured bilaterally along an X-Y axis: X from the mid-axillary line (negative medial, positive lateral) …

The Need For Innovative Changes In The Jp Drain, Devin Williams, Bs, Elizabeth Simon, Bs, Krishna Koka, Bs, Spencer Haber, Bs, Andrew Newman, Md

Phase 1

Introduction: The Jackson Pratt (JP) Drain removes surgical site fluid postoperatively. It prevents surgical site complications, however mastectomy and breast reconstruction patients report varying states of pain and quality of life (QOL) during use. The anterior chest wall is densely innervated and drain placement is not precisely controlled. We hypothesize that placement variation contributes to inconsistent patient outcomes. This prospective cohort study aims to understand the impact of drain placement on pain and QOL.

Methods: The drain sites of 30 patients undergoing breast reconstruction or mastectomy and screened for exclusion criteria are measured intraoperatively using anatomical landmarks. A validated pain …

The Need For Innovative Changes In The Jp Drain, Elizabeth Simon, Bs, Spencer Haber, Bs, Devin Williams, Bs, Krishna Koka, Bs, Andrew Newman, Md

Phase 1

Introduction: The Jackson-Pratt (JP) drain has been used post-mastectomy since 1980; however, little research has been done regarding the quality of life (QOL) associated with drains. How might we help JP drain patients following mastectomy have increased QOL during drain use? We hypothesize that specific drain placement locations relative to anatomical body wall landmarks correlate with QOL.

Methods: This is a prospective cohort study of thirty female sex patients undergoing breast mastectomy or reconstruction needing bilateral drains and excludes patients with significant confounding variables that interfere with pain data. The surgeon measures the JP drain location after placement in the …

Designing A Multilingual Instructional Language Tool For Patient Communication In Interventional Radiology, Samuel Almodóvar, Ahlam Houssein, Gregg Khodorov, Md, Mba, Sahib Sohal, Md, Robert Pugliese, Pharmd, David Dwyer, Md

Phase 1

Introduction: Current efforts to provide language-inclusive radiological care fall short, resulting in suboptimal imaging, increased procedural time, and greater radiation exposure. Inadequate language accessibility results in poor communication, suboptimal care, and increased patient dissatisfaction. A digital language tool was developed to provide patient instructions during interventional radiology (IR) procedures, addressing this gap and enhancing patient care.

Methods: Observations were carried out to better understand workflow during IR procedures and identify how to incorporate the tool. We conducted interviews with IR physicians, nurses, and technologists to gather common procedural phrases and patient instructions. Spanish and Mandarin were selected because they are …

Aura Vena, Bassem Fayek, Isaac Kravatz, Robert Pugliese, Pharmd

Phase 1

Introduction: Peripheral intravenous (IV) access remains a common problem faced across healthcare, leading to significant healthcare losses in terms of working hours, resources, as well as patient pain and discomfort. At Thomas Jefferson University Hospital’s (TJUH) infusion center, many healthcare workers utilize hot towels and disposable heat packs to warm patients’ arms if IV access is difficult- a wasteful solution that provides limited heating.

Methods: Nurses at TJUH’s infusion center were interviewed to define the problem and identify optimal product requirements for healthcare workers. In conjunction with market research, a heat-warming sleeve is designed and created. The design of the …