Digital Commons Network^™

Information Extraction From Clinical Notes: Are We Ready To Switch To Large Language Models?, Yan Hu, Xu Zuo, Yujia Zhou, Xueqing Peng, Jimin Huang, Vipina K Keloth, Vincent J Zhang, Ruey-Ling Weng, Cathy Shyr, Qingyu Chen, Xiaoqian Jiang, Kirk E Roberts, Hua Xu

Faculty, Staff and Student Publications

Objectives: To assess the performance, generalizability, and computational efficiency of instruction-tuned Large Language Model Meta AI (LLaMA)-2 and LLaMA-3 models compared to bidirectional encoder representations from transformers (BERT) for clinical information extraction (IE) tasks, specifically named entity recognition (NER) and relation extraction (RE).

Materials and methods: We developed a comprehensive annotated corpus of 1588 clinical notes from 4 data sources-UT Physicians (UTP) (1342 notes), Transcribed Medical Transcription Sample Reports and Examples (MTSamples) (146), Medical Information Mart for Intensive Care (MIMIC)-III (50), and Informatics for Integrating Biology and the Bedside (i2b2) (50), capturing 4 clinical entities (problems, tests, medications, other treatments) …

Effect Of Dynamic Fatigue Loading On The Adaptation And Retention Of Maxillary Single Dentures Reinforced With Digitally Constructed Zirconia And Cobalt–Chromium Frameworks, Ghada Elgindy, Fardos N Rizk, Marwa Ezzat Sabet, Hebatallah Tarek Mohamed

Dentistry

Background. The impact of dynamic fatigue loading on denture adaptation and retention is clinically important. Zirconia and cobalt–chromium (Co–Cr) frameworks enhance denture strength, but their performance under cyclic loading remains unclear. Objectives. The aim of the study was to evaluate the adaptation and retention of maxillary single dentures reinforced with digitally constructed Co–Cr or zirconia frameworks after a simulated 1 year of function. Material and methods. Three types of maxillary single dentures were constructed on maxillary master casts. Group A included maxillary dentures without reinforcement (control group), whereas groups B and C encompassed maxillary dentures reinforced with digitally designed and …

Frontmatter (Volume 46, Issue 3), Paul B. Mojzes

Occasional Papers on Religion in Eastern Europe

No abstract provided.

The Soviet Template And Its Application: Bulgarian State Policy Toward The Bulgarian Orthodox Church After 1944, Ventzislav Gueorgiev Karavaltchev

Occasional Papers on Religion in Eastern Europe

The article examines the adoption and implementation of Soviet models in Bulgarian state policy toward the Bulgarian Orthodox Church following the communist takeover on September 9, 1944. Situating the Bulgarian case within a broader comparative framework, the study traces key continuities between Soviet church–state relations after the October Revolution of 1917—particularly as was institutionalized during the Stalinist period—and their subsequent application in Bulgaria. Drawing on extensive archival materials from Bulgarian and Russian repositories, the article demonstrates that all major decisions concerning the Church were closely coordinated with, and often directly approved by, Moscow. Beyond repression and legal restriction, the analysis …

Hegemonial Nationalism And The Role Of Religion: A View From The Perspective Of The Western Balkans, Semir Halilović, Tomislav Tadic

Occasional Papers on Religion in Eastern Europe

This paper points to the problem of hegemonic nationalism, with an emphasis on the role of religion, in the context of a social understanding of the situation in the Western Balkans (Bosnia and Herzegovina, Serbia, Montenegro, and Croatia). The question of the “Eastern and Western models of nationalism” is articulated, and the social role of religion in their construction is examined. In relation to this framework, the possibilities for applying the thesis of the Eastern model of the nation are considered in light of the current war situation between Russia and Ukraine. The paper highlights some of the theoretical configurations …

Polygyny Between Sharia, Custom And State Law As A Persistent Dilemma In Post-Soviet Kyrgyzstan, Zharkynbai Sebetov, Mairambek Tagaev

Occasional Papers on Religion in Eastern Europe

This article presents a comprehensive study of the century-long historical and legal evolution of state-imposed prohibitions on the institution of polygyny in Kyrgyzstan. The primary objective of the research is to evaluate the outcomes of a hundred years of repressive policies – originally classified as “crimes of daily life” (bytovye prestupleniya) during the early Soviet era–and to uncover the transformed legal paradoxes of this phenomenon today. Drawing on historical archival materials, Communist Party reports, and contemporary regulatory acts, the authors investigate the fundamental reasons why polygyny persists as a resilient “shadow” institution in Kyrgyz society despite its criminalization. Within the …

Countering Wahhabism And Promoting Religious Stability In Kazakhstan: Theological Insights From Qawam Ad-Din Al-Itqani, Rizabek Battaluly, Shamshadin Kerim, Nurlan Anarbayev, Ershat Vice-Rector Ongar

Occasional Papers on Religion in Eastern Europe

Following Kazakhstan’s independence, the expansion of religious freedoms created a societal religious vacuum, which, coupled with the low level of religious literacy among youth, facilitated the spread of radical ideologies. Historical evidence indicates that Wahhabism entered the region through broader Salafi movements, doctrinally grounded in the teachings of Ibn Taymiyya, contributing notably to inter-religious tensions among younger generations. Traditional Islamic frameworks in Central Asia – the Hanafi school of jurisprudence and the Maturidi creed – have historically played a central role in maintaining religious stability. The scholarly works of Qawam ad-Din al-Itqani, a prominent intellectual from the Turkistan region, systematically …

Love And Social Justice: A Review Essay, Christopher Garbowski

Occasional Papers on Religion in Eastern Europe

Blessed Cardinal Stefan Wyszyński, Love and Social Justice: Reflections on Society, translated by Filip Mazurczak. Waterloo, On. Canada: Arouca Press, 2021. Pp 554. ISBN: 978-1-989905-90-6. Reviewed by Christopher Garbowski, Professor Emeritus of Maria Curie-Skłodowska University, Poland, OPREE Advisory Board

Cover, Florida Field Naturalist

Florida Field Naturalist

No abstract provided.

Single Port Robotic Right Level Iii Thrombectomy, Utilizing A Retroperitoneal Approach, Parker Adams, Gabriela Mazur, Adam Matynowski, Kevin Kunitsky, Savannah Grandy, Steve Ogilvy, Marne Louters, Ashley Lesser, Robenson Nguyen, Ryan J. Nelson

Student Publications

Intro/Background: Renal cell carcinoma (RCC) with associated tumor venous thrombus has historically been treated via an open or laparoscopic approach. To date there are no reported cases of performing inferior vena cava (IVC) thrombectomy using the da Vinci® Single-Port (SP) robotic platform.

North Carolina: Here we present the first reported case of a successful SP robotic right radical nephrectomy with level III IVC thrombectomy through a single incision and retroperitoneal approach. The patient is an 83-year-old female found to have a 9.6 cm right renal mass with renal vein thrombus abutting the diaphragm, and concern for metastatic disease. …

Impact Of Cyp2d6 Genotype And Inhibitor Use On Risperidone Metabolism In Children: Functional Insights Into The *17 And *29 Alleles, Matthew H. Bennett, Ethan A. Poweleit, Samuel E. Vaughn, Brandon Retke, Paul Toren, Jeffrey R. Strawn, Laura B. Ramsey

Student Publications

Risperidone, an atypical antipsychotic, is increasingly prescribed in pediatric patients with psychiatric disorders. It is primarily metabolized by CYP2D6 to 9-hydroxyrisperidone, an active metabolite associated with a higher risk of adverse effects. The CYP2D6*17 and *29 alleles are prevalent in individuals of African ancestry and less studied than variants found in European ancestry individuals. This knowledge gap contributes to differences in health outcomes in individuals of non-European origin. The primary objective of this study is to replicate recently identified risperidone-specific activity for the CYP2D6*17 and *29 alleles. During psychiatric hospitalization, CYP2D6 was genotyped as part of routine care. Remnant plasma …

Policy Considerations For Universal Congenital Cytomegalovirus Screening In Colorado: Insights From Minnesota’S Model, Elizabeth Wood

Doctoral Scholarly Projects & Capstones

Congenital cytomegalovirus (cCMV) is the most common congenital infection in developed countries and a leading non-genetic cause of sensorineural hearing loss (SNHL) and neurodevelopmental impairment in children. Despite its significant public health impact, newborn screening policies for cCMV remain inconsistent across the United States. Recent policy developments, including Minnesota’s implementation of universal newborn cCMV screening (2023) and Colorado’s adoption of an expanded-targeted screening approach (2025), have intensified discussion regarding optimal strategies for early detection and intervention. This narrative review synthesizes current evidence on the epidemiology, clinical manifestations, diagnostic methods, treatment options, and long-term outcomes of cCMV, with a particular focus …

Analysis Of Patients With Monocytic And Monocytic-Like Acute Myeloid Leukemia, Including Aml-M4 And Aml-M5, Treated With Venetoclax Plus Azacitidine, Marina Konopleva, Courtney D Dinardo, Yan Sun, Paul Jung, Sanam Loghavi, Jalaja Potluri, Monique Dail, Brenda Chyla, Daniel A Pollyea

Faculty, Staff and Student Publications

No abstract provided.

Impact Of Mutational Landscape And Burden On Rbc Transfusion Response In Patients With Lower-Risk Myelodysplastic Syndromes (Lr-Mds) In The Commands Study, Rami S Komrokji, Sheida Hayati, Manuel Ugidos, Guillermo Garcia-Manero, Matteo Giovanni Della Porta, Amer M Zeidan, Valeria Santini, Uwe Platzbecker, Anita K Gandhi, Rajasekhar N V S Suragani

Faculty, Staff and Student Publications

The COMMANDS trial established luspatercept as a first‐line treatment for anemia in transfusion‐dependent lower‐risk (LR) myelodysplastic syndromes (MDS). Here we report red blood cell (RBC) transfusion response analysis based on somatic mutations profile and disease risk for patients treated with luspatercept or epoetin alfa in the COMMANDS trial. Of 350 evaluable patients, 238 (68.0%) had MDS with multiple lineage dysplasia and ring sideroblasts (RS) according to World Health Organization 2016 criteria, and 320 (91.4%) had somatic mutations in ≥ 1 gene (median, 2) with median variant allele frequencies (VAF) of 2%–59%. Mutation profiles were similar in the treatment groups. Luspatercept …

Kras4a And Kras4b Show Distinct Lipid-Dependent Regulation Of Ras-Raf Membrane Dynamics, Konstantia Georgouli, Jeremy O.B. Tempkin, Liam G. Stanton, Tomas Oppelstrup, Rebika Shrestha, Timothy S. Carpenter, Fikret Aydin, Xiaohua Zhang, Harsh Bhatia, Yue Yang, Que N. Van, Pedro Andrade Bonilla, Gulcin Gulten, Debanjan Goswami, Francesco Di Natale, Joseph R. Chavez, Joseph Y. Moon, Gautham Dharuman, Nicolas W. Hengartner, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

KRAS4a and KRAS4b are important regulators of signaling, and their interactions with the plasma membrane are dynamic and influenced by lipid composition. KRAS 4a and 4b have nearly identical globular domains but differ in their membrane-associated hyper variable region (HVR). The functional distinctions between these isoforms remain unclear, particularly with regards to their dependence on specific lipids and the membrane environment. Previous work showed that the membrane orientation of KRAS4b affects its ability to bind to RAF kinase RBDCRD and that the KRAS–RBDCRD complex adopts different poses on the membrane as well as influences the size and composition of the …

Thermodynamically Consistent Incorporation Of The Langmuir Adsorption Model Into Compressible Fluctuating Hydrodynamics, Hyun Tae Jung, Hyungjun Kim, Alejandro L. Garcia, Andrew J. Nonaka, John B. Bell, Ishan Srivastava, Changho Kim

Faculty Research, Scholarly, and Creative Activity

For a gas–solid interfacial system where chemical species undergo reversible adsorption, we develop a mesoscopic stochastic modeling method that simulates both gas-phase hydrodynamics and surface coverage dynamics by coupling the Langmuir adsorption model with compressible fluctuating hydrodynamics. To this end, we derive a thermodynamically consistent mass–energy update scheme that accounts for how the mass and energy variables in the gas and surface subsystems should be updated according to the changes in the number of molecules of each species in each subsystem due to adsorption and desorption events. By performing a stochastic analysis for the ideal Langmuir model and the full …

Nominal Prices, Retail Investor Participation, And Return Momentum, Jun Du, Dashan Huang, Yu-Jane Liu, Yushui Shi, Avanidhar Subrahmanyam, Huacheng Zhang

Research Collection Lee Kong Chian School Of Business

We employ an identification strategy for retail participation to explore the link between return momentum and investing clientele. This scheme relies on strictly enforced round-lot rules in China, which financially constrain retail investors from participating in stocks with high nominal prices. We find that there is strong momentum in high-priced stocks, but no momentum on aggregate. This result supports the idea that noise trades of retail investors mask momentum, while other, more sophisticated investors contribute to momentum. We validate this notion by showing that retail investors with small (large) portfolios are less (more) prone to participating in stocks with high …

Interest Fit Beyond The Riasec: The Comprehensive Assessment Of Basic Interests-O*Net (Cabin-Net), Chu Chu, Kevin A. Hoff, Zihan Liu, Nicholas F. Heimpel, Anthony Greco, Frederick L. Oswald, James Rounds

Research Collection Lee Kong Chian School Of Business

Over the past half-century, Holland’s RIASEC model has dominated vocational interest research. Although the RIASEC categories effectively capture general occupational themes, their breadth obscures meaningful variability across underlying basic interests, which are more refined interest scales. In this research, we adapted the Comprehensive Assessment of Basic Interests (CABIN; Su et ., 2019) to be used alongside O*NET for assessing interest fit, resulting in the 60-item CABIN-NET that measures 20 basic interest scales organized under RIASEC domains. In Study 1, we refined items for the CABIN-NET using a nationally representative adult sample (N = 768). In Studies 2 and 3, we …

Can’T Get Work Off My Mind: The Effect Of Nonwork Goal Reflection On After-Work Rumination And Well-Being, Trevor A. Foulk, Min-Hsuan Tu, Michael Schaerer, Amber Johnson

Research Collection Lee Kong Chian School Of Business

Many employees lament that their inability to stop ruminating about work during nonwork time is one of their most significant work-related challenges, yet limited research has articulated actionable strategies to address this issue on a day-to-day basis. Integrating goal shielding theory with rumination theory, our model introduces nonwork goal reflection as a deliberate behavioral intervention employees can engage in to curtail work-related rumination, in a way that facilitates well-being during nonwork time. Specifically, we argue that engaging in nonwork goal reflection—where employees intentionally reflect on nonwork goals to be completed during their nonwork time—can curtail work-related rumination and is associated …

Global Value Chains And Economic Inequality, Vivek Soundararajan, Ari Van Assche, Hari Bapuji, Gokhan Ertug

Research Collection Lee Kong Chian School Of Business

In their inaugural editorial, Van Assche and De Marchi (2024) argued that meaningful progress in international business policy requires a more fine-grained understanding of how private international business practices intersect with public policy objectives. This editorial builds on that insight by applying it to a critical yet still underexplored issue – one on which we hope to see more research in this journal: the role of multinational enterprises (MNEs) and global value chains (GVCs) in shaping economic inequality within developing economies. Decisions related to sourcing, contracting, and GVC governance are inherently distributional rather than neutral, with important implications for how …

Skeletal Muscle Health In Childhood Cancer Survivors: A Systematic Review And Meta-Analysis, Anna Maria Markarian, Dennis R. Taaffe, Daniel A. Galvão, Carolyn J. Peddle-Mcintyre, Jodie Cochrane Wilkie, Francesco Bettariga, Nicholas G. Gottardo, Mayank Dhamija, Santosh Valvi, Catriona M. Buchanan, Kerrie Graham, Robert U. Newton

Research outputs 2022 to 2026

Purpose: Childhood cancer survivors (CCS) are at risk of long-term skeletal muscle deficits following intensive therapies during critical periods of growth. This review aimed to synthesize approaches for assessing muscle quantity, quality, and function in CCS and to quantify deficits relative to healthy peers. Methods: A systematic search was conducted in CINAHL, Embase, PubMed, SPORTDiscus, and Web of Science from inception to June 2024, with an update in November 2025. Studies including CCS who had completed cancer treatment and reported measures of muscle quantity, quality, or physical function were eligible. A three-level mixed-effects model meta-analysis was conducted. Associations between muscle …

Vibostolimab Coformulated With Pembrolizumab Versus Pembrolizumab Alone As Adjuvant Therapy For High-Risk Stage Iib–Iv Melanoma (Keyvibe-010): A Randomised, Double-Blind, Phase 3 Study, Reinhard Dummer, Jun Guo, Jason J. Luke, Matteo S. Carlino, Dirk Schadendorf, Muhammad A. Khattak, Axel Hauschild, Paolo A. Ascierto, Yu Chen, Sang Joon Shin, Piotr Rutkowski, Zhiguo Luo, Jing Chen, Gareth Rivalland, Corlia Coetzee, Antoni Ribas, Karmele Mujika, Gal Markel, Rodrigo U. Villarroel, Omer Dizdar, Christian Caglevic, Dmitri Grebennik, Kevin Donovan, Clemens Krepler, Georgina V. Long

Research outputs 2022 to 2026

Background Combination therapy with vibostolimab plus pembrolizumab has previously shown promising antitumor activity in melanoma. We aimed to evaluate the efficacy and safety of vibostolimab coformulated with pembrolizumab as adjuvant therapy for high-risk resected melanoma. Methods This randomised, double-blind, phase 3 study was done at 205 global sites (hospitals and cancer centres). Participants aged 12 years or older with surgically resected, stage IIB–IV cutaneous melanoma per the American Joint Committee on Cancer Cancer Staging Manual 2017 (8th edition), with no evidence of metastatic disease after resection, were randomly assigned (1:1) to receive vibostolimab 200 mg coformulated with pembrolizumab 200 mg …

Systematic, Bibliographic And Statistical Aspects On Multi Generation Recycled Concrete Materials Research: A Review, Henrique Comba Gomes, Maozhou Meng, Katie Jones, William Vevers, Aissa Bouaissi, Boksun Kim

School of Engineering, Computing and Mathematics

This article aimed to review the current literature related to the topic of multiple generation recycled concrete materials considering systematic, bibliographic and statistical aspects. The review was conducted from an adaptation from the systematic review for engineering and experiments (SREE) method. Papers wrote in English with scientific relevance, title and abstract full aligned with the topic were selected from Scopus and Web of Science databases. Bibliographic aspects highlighted the research novelty, the quality of research and prominence for future works. The systematic review aimed to provide insights in the literature concerning multiple recycling concrete materials. Some of the main aspects …

Assessment Of Rotator Cuff External Rotation: Isometric Vs. Isotonic Testing Modes, Luca Maestroni, Filippo Beretta, Fabio Civera, Paolo Artina, Marco Cuniberti, Francesco Bettariga, Anthony Turner

Research outputs 2022 to 2026

Objectives: To assess intra-session reliability of isometric and isotonic shoulder external rotation (ER) strength tests and to compare their outcomes. Methods: Thirty-eight healthy subjects (19 females; 19 males; 25.7 ± 6.0 years; 175 ± 9 cm; 70.3 ± 11.4 kg) completed a shoulder ER strength assessment including Prone and Standing ER Isometric tests and Seated 5 repetition maximum (RM) ER tests. Normality was checked with the Shapiro–Wilk test. Reliability was assessed using the CV and ICC (3, k, 95% CI). Linear mixed models examined sex and dominance effects. Correlations and multiple regression tested associations between tests (p < 0.05). Results: All tests performed displayed “excellent” reliability scores (CV from 1.9 to 3.1% and ICC from 0.970 to 0.994). No significant effect of dominance was observed in any strength test. Males showed significantly higher values than females in both Prone (3.8% higher, p < 0.001) and Standing (2.7% higher, p = 0.003) isometric ER strength tests. Prone and Standing isometric tests were moderately correlated (r = 0.62, 95% CI [0.46, 0.74], p < 0.001). A regression model explained 52.4% of the variance in Seated 5 RM ER strength (R² = 0.524, …

Design, Testing, And Safety Performance Of Movable Guardrail Systems: A Prisma-Based Systematic Review, Navid Hashemi Taba, Ahdieh Sadat Khatavakhotan, Majid Tolouei-Rad

Research outputs 2022 to 2026

Movable guardrail systems are increasingly used in work zones, reversible lanes, and temporary traffic operations; however, evidence on their crashworthiness, material performance, and operational reliability remains dispersed across multiple design typologies and regulatory frameworks. This PRISMA-compliant systematic review synthesizes 78 studies involving full-scale crash tests, validated finite-element simulations, field performance evaluations, and compliance evaluations under MASH, EN 1317, NCHRP 350, and AS/NZS 3845.1. The findings indicate that modular rigid barriers reliably achieve TL-3/TL-4 performance when joint alignment and foundation conditions are properly controlled; semi-rigid steel systems provide a practical balance between containment capacity and redeployability, but remain sensitive to post …

From Comfort Zone To Growth Zone: Experiential Projects As Catalysts For Creativity In Pre-Service Teachers, Serap Sevimli-Celik, Elif Güvelioglu

Research outputs 2022 to 2026

This study aimed to analyze the creative experiences of early childhood pre-service teachers enrolled in a semester-long course designed to enhance their creative potential through experiential projects. Using a qualitative research design, this study explored the subjective experiences of 16 pre-service teachers, aged 21 to 23-years-old, who participated in a 14-week course focused on integrating creativity into early childhood education. Data were collected through weekly reflections, project reports, and multimedia documentation, capturing each pre-service teacher's creative journey. The findings revealed four key themes which characterized the pre-service teachers’ creative experiences: (1) learning a new skill, (2) expressing creativity and experiencing …

Orthogonal Time Frequency Space Modulation For Underwater Acoustic Communication Systems: A Review, Bevek Subba, Quoc Viet Phung, Stefan Lachowicz, Walid K. Hasan, Muhammad Haziq, Daryoush Habibi, Iftekhar Ahmad

Research outputs 2022 to 2026

Underwater Acoustic Communication (UAC) has garnered significant attention due to its applications in marine science, defence, and exploration. With the vast majority of the Earth's surface covered by water, there is a growing demand for reliable and effective communication techniques in underwater environments. However, the underwater acoustic channel is the most challenging channel due to its harsh characteristics, which significantly hinder the reliability and performance of UAC systems. Orthogonal Time Frequency Space (OTFS) modulation has emerged as a promising solution for next-generation UAC systems to address high Doppler and high mobility scenarios. It has demonstrated tolerance to fast time-varying channel …

Shear Stability Enhancement In Fracture Plugging Zones: Unveiling Failure Mechanisms And Adhesive Benefits Through Photoelastic Analysis, Haoran Jing, Yili Kang, Chengyuan Xu, Lei Liu, Xiaopeng Yan, Zhenjiang You

Research outputs 2022 to 2026

Addressing lost circulation during drilling operations typically involves the utilization of lost circulation materials (LCMs) to create a fracture plugging zone (FPZ), which effectively decouples the wellbore fluid column pressure (Pw) from the formation pressure (Pf). This FPZ, comprised of aggregated granular LCM particles, frequently succumbs to shear stress, with shear failure being the predominant mode of structural failure, leading to ongoing fluid losses. To illuminate the failure mechanisms of the FPZ under conditions of escalating drilling differential pressure (Pw - Pf), we utilized photoelastic experiments to capture and visualize the evolving mesoscopic mechanical structure of the FPZ. Photoelastic images …

Unilateral Online Ultrasound Stimulation Of Early Visual Cortex Suppresses Responses To Contralateral Visual Stimuli, Suraya Dunsford, Keith Murphy, Ema Darrieutort, Elsa Fouragnan, Giorgio Ganis

School of Psychology

INTRODUCTION: Transcranial ultrasound stimulation (TUS) shows great promise for inducing neuroplastic changes that persist long after stimulation. Evidence of stimulation-locked (online) neural changes would enable the development of closed-loop application of TUS. However, such responses have been difficult to distinguish from coincident neural activity caused by auditory and somatosensory effects of TUS.

METHODS: To dissociate genuine online neuromodulatory effects from peripheral confounds, we leveraged the contralateral retinotopic organization of the early visual cortex in nineteen subjects. Using a hemifield visual stimulation paradigm combined with high-precision, functional MRI-guided TUS, we applied TUS to the left early visual cortex while participants viewed …

Magnetically Driven Engineering Of Magnetic Hydroxyapatite/Ca Ro Membranes: Enhancing Surface Physicochemical Properties For High-Performance Water Desalination, Fariba Oulad, Ali Akbar Zinatizadeh, Sirus Zinadini, Amir Razmjou, Sara Eavani

Research outputs 2022 to 2026

This research focuses on the development of innovative hydrophilic reverse osmosis (RO) hydroxyapatite/cellulose acetate (HAP/CA) and magnetic-hydroxyapatite (M-HAP)/CA membranes, utilizing a phase-inversion technique with varying nanoparticles (NPs) concentration. The positioning of magneto-responsive M-HAP NPs within the advanced M-HAP/CA membranes was adeptly controlled using magnetic guidance during immersion- precipitation process in a coagulation bath. This precise control enabled a densely organized arrangement of M-HAP NPs, shifting from the membrane's core to its upper separation layer. Consequently, the barrier properties, mechanical integrity, and surface characteristics of the advanced M-HAP/CA membranes saw significant enhancement due to the uniform distribution of hydrophilic porous NPs …