Digital Commons Network^™

Lagrangian Modelling Of Nonlinear Viscous Waves Generated By Moving Seabed Deformation, E. Renzi, S. Michele, A. G.L. Borthwick, A. C. Raby

School of Engineering, Computing and Mathematics

A Lagrangian flow model is used to investigate highly nonlinear, dispersive waves generated by moving seabed deformation (MSD) of an otherwise horizontal seabed. Applications include free surface wave responses to horizontal co-seismic displacements and to novel bed-driven wave making systems used in surfing competitions. This paper considers gravity waves in viscous liquid, without restrictions on wave steepness, dispersion coefficient, and flow regime. Numerical computations are carried out using a Moving Particle Explicit method, which provides a Lagrangian flow description with far fewer particles than existing meshless methods. We show that the MSD speed has different effects in shallow and intermediate …

Identifying Resilience Strategies For Disruption Management In The Healthcare Supply Chain During Covid-19 By Digital Innovations: A Systematic Literature Review, Goli Arji, Hossein Ahmadi, Pejman Avazpoor, Morteza Hemmat

School of Nursing and Midwifery

The worldwide spread of the COVID-19 disease has had a catastrophic effect on healthcare supply chains. The current manuscript systematically analyzes existing studies mitigating strategies for disruption management in the healthcare supply chain during COVID-19. Using a systematic approach, we recognized 35 related papers. Artificial intelligence (AI), block chain, big data analytics, and simulation are the most important technologies employed in supply chain management in healthcare. The findings reveal that the published research has concentrated mainly on generating resilience plans for the management of COVID-19 impacts. Furthermore, the vulnerability of healthcare supply chains and the necessity of establishing better resilience …

Serviceability Behaviour Of Frp-Reinforced Slatted Slabs Made Of High-Content Recycled Aggregate Concrete, Thanongsak Imjai, Reyes Garcia, Boksun Kim, Chayanon Hansapinyo, Piti Sukontasukkul

School of Engineering, Computing and Mathematics

At service load levels, shear-induced deflections of reinforced concrete (RC) slabs are small and therefore they are usually ignored in deflection calculations. However, shear-induced deflections can be large in RC slabs reinforced with Fibre Reinforced Polymer (FRP) bars, especially after the development of diagonal cracks. This article investigates the serviceability behaviour (deflections and crack widths) of FRP-reinforced slatted slabs cast with recycled aggregate concrete (RAC). Fifteen slabs were tested in flexure, including five slabs cast with normal concrete (NC), five slabs cast with RAC made with 50% recycled concrete aggregate, and five slabs cast with RAC made with 100% recycled …

Patients With Low Socio-Economic Status (Ses): What Are Their Perceptions And Experiences Of Mental Health Provision Within Primary Care?, Katy Stevenson

Peninsula Medical School

No abstract provided.

Who Are The Marine Fungi?, Michael Cunliffe

School of Biological and Marine Sciences

Fungi are widespread throughout marine habitats. Most marine fungi are microscopic, either microfungi, yeasts, or swimming zoospore-producing groups such as the Chytridiomycota (‘the chytrids’). The macroscopic exceptions are the marine lichens along coastlines. Marine mushrooms are yet to be discovered. The functional roles of marine fungi include parasites (e.g., infecting phytoplankton; Hassett & Gradinger, 2016), saprotrophs recycling organic matter (e.g., degrading phytoplanktonproduced polysaccharides; Cunliffe et al., 2017) and in symbiosis with other marine life (e.g., seaweeds; Bonthond et al., 2022). Here, I briefly summarize my perspective of marine fungi with an emphasis on identity. Looking into the crystal ball, I …

An Evidence-Based Approach To Provide Essential And Desirable Components To Develop Surveys On Sudden Unexpected Death In Epilepsy (Sudep) For Doctors: A Focused Review, L. V. Watkins, S. Ashby, J. Hanna, W. Henley, R. Laugharne, R. Shankar

Peninsula Medical School

Sudden Unexpected Death in Epilepsy (SUDEP) is a major concern for people with epilepsy, their families, their care givers, and medical professionals. There is inconsistency in the SUDEP counselling doctors provide, compared to what is recommended in clinical guidelines. Numerous national and international surveys have highlighted how epilepsy professionals, usually doctors, deliver SUDEP risk counselling, particularly, when they deliver it and to whom. These surveys help understand the unmet need, develop suitable strategies, and raise awareness among clinicians with the eventual goal to reduce SUDEPs. However, there is no standardised survey or essential set of questions identified that can be …

Organisms In A Changing World, Melody S. Clark, Ariel Shabtay, Elizabeth R. Waters, Manuela Truebano

School of Biological and Marine Sciences

Since its foundation in 1999 by Lawrence Hightower, the Cell Stress Society International (CSSI) has actively promoted international collaboration in the field of stress research. Over the years, the Society has gone from strength to strength, with one of its main, and highly, visible outputs being the journal ‘Cell Stress & Chaperones’. Although initially, the full title of the journal was ‘Cell Stress & Chaperones: An Integrative Journal of Stress Biology and Medicine’ with an emphasis on the medical feld, original scientifc articles were always welcomed from a wide range of organisms and diferent aspects of stress molecular biology. However, …

Cardiovascular Risk Factors In Secondary Progressive Multiple Sclerosis: A Cross‐Sectional Analysis From The Ms‐Stat2 Randomized Controlled Trial, Thomas Williams, Nevin John, Alberto Calvi, Alessia Bianchi, Floriana De Angelis, Anisha Doshi, Sarah Wright, Madiha Shatila, Marios C. Yiannakas, Fatima Chowdhury, Jon Stutters, Antonio Ricciardi, Ferran Prados, David Macmanus, Marie Braisher, James Blackstone, Olga Ciccarelli, Cam Gandini Wheeler‐Kingshott, Frederik Barkhof, Jeremy Chataway, Jeremy Hobart

Peninsula Medical School

Background and purpose.There is increasing evidence that cardiovascular risk (CVR) contributes to disability progression in multiple sclerosis (MS). CVR is particularly prevalent in secondary progressive MS (SPMS) and can be quantified through validated composite CVR scores. The aim was to examine the cross‐sectional relationships between excess modifiable CVR, whole and regional brain atrophy on magnetic resonance imaging, and disability in patients with SPMS. Methods. Participants had SPMS, and data were collected at enrolment into the MS‐STAT2 trial. Composite CVR scores were calculated using the QRISK3 software. Prematurely achieved CVR due to modifiable risk factors was expressed as QRISK3 premature CVR, …

The Experiences Of Uncertainty Amongst Musculoskeletal Physiotherapists In First Contact Practitioner Roles Within Primary Care, Simon Ingram, Robert Stenner, Sue May

School of Health Professions

Aim: The aim of this research was to explore the experiences of uncertainty amongst Musculoskeletal First Contact Practitioners working in primary care.Background: The Musculoskeletal First Contact Practitioner role involves advanced physiotherapists providing an alternative to the GP by acting as first point of contact for people presenting to primary care with musculoskeletal conditions. Limited research into the role exists but the first-contact aspect, clinical complexity and time pressures are deemed to contribute to uncertainty within the role.Method: A qualitative research design was undertaken using a hermeneutic interpretative phenomenological approach. Data was collected using semi-structured interviews with subsequent thematic analysis of …

Poo Matters! A Scoping Review Of Impact Of Constipation On Epilepsy, Alexandra Gabrielsson, Samuel Tromans, Lance Watkins, Lisa Burrows, Richard Laugharne, Rohit Shankar

Peninsula Medical School

BACKGROUND: Epilepsy is a common neurological disorder which frequently presents with co-morbid physical health conditions, including constipation. However, the nature of the relationship between the two conditions has not been well defined. AIM: To quantify constipation's relationship with epilepsy and anti-seizure medication (ASM). METHOD: A scoping review registered on PROSPERO (CRD42022320079) with suitable search terms was conducted and reported in accordance with PRISMA guidance. CINAHL, Embase, PsycInfo and MEDLINE electronic databases were searched by an information specialist. The Joanna Briggs Institute (JBI) critical appraisal tools alongside the Oxford Centre for Evidence Based Medicine (OCEBM) levels of evidence were used to …

Marine Environmental Effects On A Graphene Reinforced Epoxy Adhered Single Lap Joint Between Metals And Cfrp, Rudi Fry-Taylor, Maozhou Meng, Xinyu Wang

School of Engineering, Computing and Mathematics

This study investigates the marine environmental effects on the bonding strength of graphene nanoplatelets (GNPs) reinforced adhesive for a metal/composite single lap joint. Samples were immersed for periods of 1, 2 and 3 weeks in a 50 °C, 3.5% NaCl solution, with the purpose of the heat being the creation of an environment in which simulated an increased ageing period in the joint structure. In a dry condition, the use of GNPs produced a slight increase in lap shear strength of 17% and 14% in the carbon fibre reinforced plastics (CFRP) composite laminate to aluminium and stainless-steel joints respectively. Post …

Emergency Department Presentations Of Diabetic Ketoacidosis In A Large Cohort Of Children, Jeff E Schunk, Michael J Stoner, Arleta Rewers, Julie K Mcmanemy, Kimberly S Quayle, Jennifer L Trainor, Leah Tzimenatos, Jonathan E Bennett, Maria Y Kwok, Sage R Myers, Kathleen M Brown, T Charles Casper, Cody S Olsen, Nicole S Glaser

Faculty, Staff and Students Publications

Background: Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of childhood diabetes. However, the influence of demographic factors on presentation are not well-defined.

Methods: We included children from 12 centers who were < 18 years with DKA (glucose > 300 mg/dL, serum pH < 7.25, or serum bicarbonate < 15 mEq/L) enrolled in the Pediatric Emergency Care Applied Research Network (PECARN) Fluid Therapies Under Investigation in DKA (FLUID) Trial. Data were also collected for children who presented to the centers during the enrollment period but were not enrolled due to disease or treatment-related reasons. We compared demographic, clinical, and biochemical findings among children with newly and previously diagnosed diabetes and children in different age groups.

Results: Of the 1,679 DKA episodes in 1,553 children, 799 (47.5%) episodes occurred in children with newly diagnosed diabetes and 396 (23.6%) were severe (pH < 7.1). Newly diagnosed children < 6 years of age were not more likely to have severe DKA in terms of pH, but had more severe hypocarbia and higher blood urea nitrogen levels, factors previously associated with the risk of cerebral injury. Lower socioeconomic status (SES) (based on family income and maternal education level) were associated with more severe DKA in new onset children, and recurrent DKA in the previously diagnosed children.

Conclusions: Greater efforts are needed to identify the children with diabetes early and to prevent recurrent DKA, particularly among children in low-SES groups. Young children with DKA may need more intensive monitoring due to higher risk of cerebral injury.

Clinical Approach To Evaluation Of Underlying Cardiac Device Infection In Patients Hospitalized With Bacteremia

Faculty, Staff and Students Publications

More than 400,000 cardiac implantable electronic devices (CIEDs), including permanent pacemakers, implantable cardioverter-defibrillators, and cardiac resynchronization therapy devices, are implanted every year in the United States (US). Infection is a serious complication of CIED therapy and is associated with high morbidity and mortality. While CIED pocket infection can be diagnosed based on clinical exam findings, positive blood culture may be the only manifestation of CIED lead infection. Thus, management of bacteremia in patients living with CIEDs requires special consideration. This review summarizes contemporary data in the context of the recently updated 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for …

Cerebrospinal Fluid Biomarkers Provide Evidence For Kidney-Brain Axis Involvement In Cerebral Malaria Pathogenesis, Anthony Batte, Paul Bangirana, Adnan Gopinadhan, Kagan A Mellencamp, Ayse Akcan-Arikan, Richard Idro, Chandy C John

Faculty, Staff and Students Publications

INTRODUCTION: Cerebral malaria is one of the most severe manifestations of malaria and is a leading cause of acquired neurodisability in African children. Recent studies suggest acute kidney injury (AKI) is a risk factor for brain injury in cerebral malaria. The present study evaluates potential mechanisms of brain injury in cerebral malaria by evaluating changes in cerebrospinal fluid measures of brain injury with respect to severe malaria complications. Specifically, we attempt to delineate mechanisms of injury focusing on blood-brain-barrier integrity and acute metabolic changes that may underlie kidney-brain crosstalk in severe malaria.

METHODS: We evaluated 30 cerebrospinal fluid (CSF) markers …

Characteristics Of Type 2 Diabetes In Female And Male Youth, Ahmad Rafaey, Siripoom Mckay, Fida Bacha, Ashok Balasubramanyam, Maria J Redondo

Faculty, Staff and Students Publications

The incidence of type 2 diabetes in children is rising and carries a worse prognosis than in adults. The influence of sex on pediatric type 2 diabetes outcomes has not been well investigated. We studied 715 youth with type 2 diabetes diagnosed at a median age of 13.7 years and compared sex differences in demographic, clinical, and laboratory characteristics within the first year of diagnosis. Females diagnosed with type 2 diabetes were younger and at a higher stage of pubertal development than males, yet presented with lower A1Cs, a lower prevalence of diabetic ketoacidosis, and higher HDL cholesterol levels.

Sphingolipids In Neurodegenerative Diseases, Hugo J Bellen

Faculty, Staff and Students Publications

Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is affected in a surprisingly broad set of NDDs. These include some lysosomal storage diseases (LSDs), hereditary sensory and autonomous neuropathy (HSAN), hereditary spastic paraplegia (HSP), infantile neuroaxonal dystrophy (INAD), Friedreich’s ataxia (FRDA), as well as some forms of amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). Many of these diseases have been modeled in Drosophila melanogaster and are associated with elevated levels of ceramides. Similar changes have also been reported in vertebrate cells and mouse models. Here, we …

Primary Spinal Intramedullary Anaplastic Ganglioglioma In A Pediatric Patient, Marc Prablek, Frank Y Lin, Melissa M Blessing, Guillermo Aldave, David Bauer

Faculty, Staff and Students Publications

BACKGROUND: Gangliogliomas (GGs) are rare tumors of the central nervous system composed of neoplastic neural and glial cells and are typically low-grade. Intramedullary spinal anaplastic GGs (AGG) are rare, poorly understood, and often aggressive tumors that can result in widespread progression along the craniospinal axis. Due to the rarity of these tumors, data are lacking to guide clinical and pathologic diagnosis and standard of care treatment. Here, we present a case of pediatric spinal AGG to provide information on our institutional approach to work-up and to highlight unique molecular pathology.

CASE DESCRIPTION: A 13-year-old female presented with signs of spinal …

Diagnostic Performance Of Point-Of-Use Ultrasound Of Resuscitation Outcomes: A Systematic Review And Meta-Analysis Of 3265 Patients, Aleksandra Gasecka, Tomasz Michalski, Pawel Wroblewski, Halla Kaminska, Gabriela Borkowska, Ewa Skrzypek, Adam Smereka, Jaroslaw Meyer-Szary, Sylwia Marciniak, Mariola Malecka

Faculty, Staff and Students Publications

BACKGROUND: Echocardiography in the setting of resuscitation can provide information as to the cause of the cardiac arrest, as well as indicators of futility. This systematic review and meta-analysis were performed to determine the value of point-of-care ultrasonography (PoCUS) in the assessment of survival for adult patients with cardiac arrest.

METHODS: This meta-analysis was performed in adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, EMBASE, Web of Science, Cochrane have been searched from databases inception until March 2nd 2021. The search was limited to adult patients with cardiac arrest and without publication dates or …

Review Of Acute Kidney Injury And Progression To Chronic Kidney Disease In Pediatric Patients Undergoing Hematopoietic Cell Transplant

Faculty, Staff and Students Publications

While acute kidney injury (AKI) after hematopoietic cell transplant (HCT) has been well-described in pediatric patients, literature regarding the long term renal consequences of HCT-related AKI, the development of chronic kidney disease (CKD), and CKD care in pediatric patients post-HCT is limited. CKD affects almost 50% of patients after HCT with multifactorial etiology including infection, nephrotoxic medications, transplant-associated thrombotic microangiopathy, graft-versus-host disease, and sinusoidal obstruction syndrome. As renal function declines in CKD, eventually progressing to end stage kidney disease (ESKD), mortality increases and is more than 80% among patients requiring dialysis. Using society guidelines and current literature, this review summarizes …

Pre-Treatment Inflamed Tumor Immune Microenvironment Is Associated With Folfirinox Response In Pancreatic Cancer, Joseph Azar, George Van Buren, William Fisher, Zequn Sun, Mark P Rubinstein, Hyun-Sung Lee, E Ramsay Camp

Faculty, Staff and Students Publications

INTRODUCTION: Pancreatic adenocarcinoma (PDAC) is an aggressive tumor with limited response to both chemotherapy and immunotherapy. Pre-treatment tumor features within the tumor immune microenvironment (TiME) may influence treatment response. We hypothesized that the pre-treatment TiME composition differs between metastatic and primary lesions and would be associated with response to modified FOLFIRINOX (mFFX) or gemcitabine-based (Gem-based) therapy.

METHODS: Using RNAseq data from a cohort of treatment-naïve, advanced PDAC patients in the COMPASS trial, differential gene expression analysis of key immunomodulatory genes in were analyzed based on multiple parameters including tumor site, response to mFFX, and response to Gem-based treatment. The relative …

Concurrent Idh1 And Idh2 Mutations In Glioblastoma: A Case Report, Maryam Haider, Ganesh Rao, Leomar Y Ballester, Gregory N Fuller

Faculty, Staff and Students Publications

Isocitrate dehydrogenase (IDH) mutations are cornerstone diagnostic features in glioma classification. IDH mutations are typically characterized by mutually exclusive amino acid substitutions in the genes encoding for the IDH1 and the IDH2 enzyme isoforms. We report our institutional case of a diffuse astrocytoma with progression to secondary glioblastoma and concurrent IDH1/IDH2 mutations. A 49-year-old male underwent a subtotal resection of a lobular lesion within the right insula in 2013, revealing a WHO grade 3 anaplastic oligoastrocytoma, IDH1 mutated, 1p19q intact. Symptomatic tumor progression was suspected in 2018, leading to a surgical tumor biopsy that demonstrated WHO grade 4 IDH1 and …

Mofx-Db: An Online Database Of Computational Adsorption Data For Nanoporous Materials, N. Scott Bobbitt, Kaihang Shi, Benjamin J. Bucior, Haoyuan Chen, Nathaniel Tracy-Amoroso, Zhao Li

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Machine learning and data mining coupled with molecular modeling have become powerful tools for materials discovery. Metal–organic frameworks (MOFs) are a rich area for this due to their modular construction and numerous applications. Here, we make data from several previous large-scale studies in MOFs and zeolites from our groups (and new data for N2 and Ar adsorption in MOFs) easily accessible in one place. The database includes over three million simulated adsorption data points for H2, CH4, CO2, Xe, Kr, Ar, and N2 in over 160 000 MOFs and 286 zeolites, textural properties like pore sizes and surface areas, and …

Equity In Focus : Investigating Gender Disparities In Glioblastoma Via Propensity Score Matching, Solomon Eshun

School of Mathematical & Statistical Sciences Faculty Publications

Gender disparities in health outcomes have garnered significant attention, prompting investigations into their underlying causes. Glioblastoma (GBM), a devastating and highly aggressive form of brain tumor, serves as a case for such inquiries. Despite the mounting evidence on gender disparities in GBM outcomes, investigations specific at the molecular level remain scarce and often limited by confounding biases in observational studies. In this study, I aimed to investigate the gender-related differences in GBM outcomes using propensity score matching (PSM) to control for potential confounding variables. The data used was accessed from the Cancer Genome Atlas (TCGA), encompassing factors such as gender, …

The Importance Of The Pressure Anisotropy Induced By Strong Magnetic Fields On Neutron Star Physics, Efrain J. Ferrer, Aric Hackebill

Physics & Astronomy Faculty Publications

In this paper we discuss in some detail how the pressures determined from semi-classical statistical averaging of the energy momentum tensor in the presence of a uniform background magnetic field are anisotropic with different pressures arising along and perpendicular to the magnetic field direction. Hence, we analyze how this result can affect two important characteristics of dense magnetized systems: (i) The hadron-quark phase transition in the presence of a magnetic field, (ii) The behavior of the speed of sound in dense magnetized systems. Taking into account that large magnetic fields are expected to be present in the interior of neutron …

Bouwsma’S 1949-1951 Commonplace Book (Selections), Ronald E. Hustwit Sr., O.K. Bouwsma

O.K. Bouwsma Collection

These selections were taken from over 250 handwritten commonplace book entries made over a two-year period when Bouwsma, on leave from the University of Nebraska and on Fulbright Fellowship at Oxford, spent time discussing philosophy with Wittgenstein at Cornell, Smith College, as well as Oxford. The selected entries also contain discussions Bouwsma had with Elizabeth Anscombe, Yorick Smythies, and other prominent American and British philosophers in this time period.

Cannabidiol And Delta-9-Tetrahydrocannabinol Interactions In Male And Female Rats With Persistent Inflammatory Pain, Stevie C. Britch, Rebecca M. Craft

Behavioral Science Faculty Publications

Cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), 2 of the primary constituents of cannabis, are used by some individuals to self-treat chronic pain. It is unclear whether the painrelieving effects of CBD alone and in combination with THC are consistent across genders and among types of pain. The present study compared the effects of CBD and THC given alone and in combination in male and female rats with Complete Freund’s adjuvant-induced inflammatory pain. After induction of hindpaw inflammation, vehicle, CBD (0.05−2.5 mg/kg), THC (0.05−2.0 mg/kg), or a CBD: THC combination (3:1, 1:1, or 1:3 dose ratio) was administered i.p. twice daily for …

The Pandemic-Uncanny: Self-Estrangement And Environment In Out There And Bliss Montage, Kersten Khaley

Dissertations and Theses @ UNI

COVID-19 was declared a pandemic by the WHO on March 11, 2020. The COVID-19 Public Health Emergency lasted from January 30, 2020, to May 11, 2023. During this time, abundant literature across disciplines began appearing, assessing the pandemic experience and aftermath. However, there needs to be more investigation and application of the term uncanny in the pandemic experience and literature.

Two short story collections, Out There by Kate Folk and Bliss Montage by Ling Ma, both published in 2022, are works of pandemic literature demonstrating the pandemic's inherent uncanniness and the human experience. The term pandemic-uncanny represents an inherent attachment …

Feedback Loops: Feedback Fundamentals, Patrick Barry

Books

Learning how to give and receive feedback is fundamental to the development of every student and professional. Yet few of us are ever taught anything like “feedback skills.”

This book, which is the first in the Feedback Loops series, is designed to change that. Here is what students who have taken the University of Michigan Law School course on which the series is based have said about it:

“One of the most memorable and useful classes I have taken in law school!”

“Excellent, full stop.”

“This class was always a fun highlight of my week.”

Exploring Grades 3-5 Mathematics Activities Found Online, Lara Dick, Amanda Sawyer, Margaret Macneille, Emily Shapiro, Tabitha Wismer

Faculty Journal Articles

We investigate resources on TeachersPayTeachers and discuss how what is available affects our teaching practices.

Roots: Korean Diaspora, Andre Lee Bassuet, As220 Printshop, Special Collections, Fleet Library

Artists' Books

75 pages : color illustrations. Numbered edition of 100 copies. Date of publication from colophon. In clamshell box (25.5 x 20 x 3 cm). Box covered in brown velor fabric with tan stitching that looks like the stem of a plant. "Parts of the book .. printed at AS220, RISD, Brown University as well as Outlet, Staples, and Minuteman Press." -- colophon. Types and sizes of paper varies, some folded, mounted, tipped-in, etc. Stab binding with black thread. Bassuet also wrote the foreword, front cover calligraphy, illustrated the back cover, and served as the publication's art director. A collaborative artist …