Digital Commons Network^™

Range And Consistency Of Cardiovascular Outcomes Reported By Clinical Trials In Kidney Transplant Recipients: A Systematic Review, Allison Tong, Jonathan C Craig, Benedicte Sautenet, Klemens Budde, Derek Forfang, John Gill, William G Herrington, Tazeen H Jafar, David W Johnson, Vera Krane, Adeera Levin, Jolanta Malyszko, Patrick Rossignol, Deirdre Sawinski, Nicole Scholes-Robertons, Giovanni Strippoli, Angela Wang, Wolfgang C Winkelmayer, Carmel M Hawley, Andrea K Viecelli

Faculty, Staff and Students Publications

BACKGROIUND: Cardiovascular disease is a major cause of morbidity and mortality in kidney transplant recipients. Trial evidence to improve cardiovascular outcomes is limited by inconsistent reporting of outcomes, which may also lack patient-relevance. This study aimed to assess the range and consistency of cardiovascular outcomes reported by contemporary trials in kidney transplant recipients.

METHODS: A systematic review of all randomized controlled trials involving adult kidney transplant recipients that reported at least 1 cardiovascular outcome from January 2012 to December 2019 was performed, including Embase, MEDLINE, Cochrane, and ClinicalTrials.gov electronic databases. Trial characteristics were extracted and all levels of specification of …

Documented Adverse Drug Reactions And Discontinuation Of Angiotensin-Converting Enzyme Inhibitors And Angiotensin Receptor Blockers In Chronic Kidney Disease, Julia M Akeroyd, Shehrezade A Jafry, Glenn T Gobbel, Sheena Wydermyer, Jennifer Arney, Adriana Hung, Michael E Matheny, Salim S Virani, Sankar D Navaneethan

Faculty, Staff and Students Publications

INTRODUCTION: Angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) are frequently discontinued in patients with chronic kidney disease (CKD). Documented adverse drug reactions (ADRs) in medical records may provide insight into the reasons for treatment discontinuation.

METHODS: In this retrospective cohort of US veterans from 2005 to 2019, we identified individuals with CKD and a current prescription for an ACEi or ARB (current user group) or a discontinued prescription within the preceding 5 years (discontinued group). Documented ADRs in structured datasets associated with an ACEi or ARB were categorized into 17 pre-specified groups. Logistic regression assessed associations of documented …

Nanocurcumin Combined With Insulin Alleviates Diabetic Kidney Disease Through P38/P53 Signaling Axis, Dianxiong Zou, Meenakshi Arora, Richard Friend, David Sheikh-Hamad, Rita Basu, M N V Ravi Kumar

Faculty, Staff and Students Publications

Treatments for diabetic kidney disease (DKD) mainly focus on managing hyperglycemia and hypertension, but emerging evidence suggests that inflammation also plays a role in the pathogenesis of DKD. This 10-week study evaluated the efficacy of daily oral nanoparticulate-curcumin (nCUR) together with long-acting insulin (INS) to treat DKD in a rodent model. Diabetic rats were dosed with unformulated CUR alone, nCUR alone or together with INS, or INS alone. The progression of diabetes was reflected by increases in plasma fructosamine, blood urea nitrogen, creatinine, bilirubin, ALP, and decrease in albumin and globulins. These aberrancies were remedied by nCUR+INS or INS but …

Distinct Temporal Trajectories And Risk Factors For Post-Acute Sequelae Of Sars-Cov-2 Infection, Michelle J Wu, Katherine A Drake, Vanessa K Ridaura, Howard C Zisser, William A Conrad, Victor F Tapson, James N Moy, Christopher R Defilippi, Ivan O Rosas, Bellur S Prabhakar, Mujeeb Basit, Mirella Salvatore, Jerry A Krishnan, Charles C Kim

Faculty, Staff and Students Publications

BACKGROUND: The understanding of Post-acute sequelae of SARS-CoV-2 infection (PASC) can be improved by longitudinal assessment of symptoms encompassing the acute illness period. To gain insight into the various disease trajectories of PASC, we assessed symptom evolution and clinical factors associated with the development of PASC over 3 months, starting with the acute illness period.

METHODS: We conducted a prospective cohort study to identify parameters associated with PASC. We performed cluster and case control analyses of clinical data, including symptomatology collected over 3 months following infection.

RESULTS: We identified three phenotypic clusters associated with PASC that could be characterized as …

Corrigendum: Alveolar Macrophages In Lung Cancer: Opportunities And Challenges, Farrah Kheradmand

Faculty, Staff and Students Publications

In the published article, there was an error in the article title. Instead of “Alveolar Macrophages in Lung Cancer: Opportunities Challenges”, it should be “Alveolar Macrophages in Lung Cancer: Opportunities and Challenges”.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Cc16 Drives Vla-2-Dependent Splunc1 Expression, Michael D L Johnson, Joselyn Rojas-Quintero, Francesca Polverino, Stefano Guerra, Xingnan Li, Darren A Cusanovich, Paul R Langlais, Julie G Ledford

Faculty, Staff and Students Publications

RATIONALE: CC16 (Club Cell Secretory Protein) is a protein produced by club cells and other non-ciliated epithelial cells within the lungs. CC16 has been shown to protect against the development of obstructive lung diseases and attenuate pulmonary pathogen burden. Despite recent advances in understanding CC16 effects in circulation, the biological mechanisms of CC16 in pulmonary epithelial responses have not been elucidated.

OBJECTIVES: We sought to determine if CC16 deficiency impairs epithelial-driven host responses and identify novel receptors expressed within the pulmonary epithelium through which CC16 imparts activity.

METHODS: We utilized mass spectrometry and quantitative proteomics to investigate how CC16 deficiency …

5-Aminolevulinic Acid, Fluorescein Sodium, And Indocyanine Green For Glioma Margin Detection: Analysis Of Operating Wide-Field And Confocal Microscopy In Glioma Models Of Various Grades, Vadim A Byvaltsev, Talgat Kerymbayev, Kwanha Yu, Debbie R Healey, Ernesto Luna-Melendez, Benjamin Deneen, Shwetal Mehta, James K Liu, Mark C Preul

Faculty, Staff and Students Publications

INTRODUCTION: Surgical resection remains the first-line treatment for gliomas. Several fluorescent dyes are currently in use to augment intraoperative tumor visualization, but information on their comparative effectiveness is lacking. We performed systematic assessment of fluorescein sodium (FNa), 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX), and indocyanine green (ICG) fluorescence in various glioma models using advanced fluorescence imaging techniques.

METHODS: Four glioma models were used: GL261 (high-grade model), GB3 (low-grade model), and an

RESULTS: Our systematic analysis showed that wide-field imaging of highly malignant gliomas is equally efficient with 5-ALA, FNa, and ICG, although FNa is associated with more false-positive staining of …

Perceived Marginalization, Social Support, And Mental Health: The Role Of Parasocial Relationships, Madison Christy, Aimee Adam

Modern Psychological Studies

The purpose of the current study was to extend previous research (Woznicki et al., 2020) to see if parasocial relationships (PSRs) with figures from various social media platforms might be beneficial for those lower in real-life social support. We predicted that there would be a negative relationship between social support and perceptions of marginalization, loneliness, and depression, but that for people who perceived themselves as marginalized, the relationship between social support and loneliness would change depending on the strength of their PSR. In this correlational study, 135 participants took an online Qualtrics survey which assessed social media use, PSR strength, …

Toward A Holistic Understanding Of Conduct Disorder Across The Lifespan, Bobby R. J. W. Mchardy, Pamela M. Seeds

Modern Psychological Studies

Conduct Disorder is a developmental disorder characterized by clinically significant and culturally unexpected aggressive and antisocial behaviors. While much work has focused on the numerous predisposing genetic, neurobiological, psychological, and environmental risk factors for Conduct Disorder, its causal mechanisms, several developmental trajectories, and interacting risks have still yet to be properly elucidated within the context of these factors. With the aim of integrating the literature’s current understanding of Conduct Disorder, we searched APA PsycNet and Google Scholar using a scoping review to select peer-reviewed articles relating to age of onset, presentation, trajectory, persistence, and outcomes of Conduct Disorder. Of the …

The Effects Of Self-Affirmation On Covid-19 Safe Behaviors, Matt Betashour

Modern Psychological Studies

This paper aims to seek if self-affirming activities can be used to increase compliance with group-protective public health policy such as the mandate to wear face masks for the COVID-19 pandemic. Completing a self-affirmation has been shown to increase compliance to health advice when it is beneficial for the self (Sherman & Cohen, 2020). To determine if self-affirming activities, as described by Self-Affirmation theory, increases compliance to health advice that is beneficial for others, the present experiment (N = 106) asked university students to complete a self-affirmation or a control task, read a relevant article, and rate how often they …

The Relationship Between Religiosity And Mental Health During The Covid-19 Quarantine, Luisauny Gomez, Jeremiah Sullins

Modern Psychological Studies

Social isolation has become a public policy under the current circumstances. This isolation can lead to a life imbalance that is believed to affect physical, psychological, and spiritual well-being. Previous research shows that both, a defined sense of religiosity or affirmative secularity, can yield progressive emotional outcomes due to multiple factors such as community support, sense of structure, life guidance, mindfulness and a sense of unity with the world. However, a gap exists in the extant literature regarding the relationship between mental health and religiosity during global pandemics. To address this gap, this study sought to answer the following question: …

Autonomous Sensory Meridian Response (Asmr) Use In College Students, Pratibha Gautam, Gina Mariano, Frank Hammonds

Modern Psychological Studies

Autonomous Sensory Meridian Response (ASMR) is the experience of tingling sensations in the crown and back of the head as a response to a range of audio-visual triggers such as whispering, tapping, and hand movements (Hostler, 2020). The number of people who produce and utilize ASMR inducing media has increased in the last few years, but little research has been done investigating its use among college students. This experimental study sought to investigate if viewing ASMR videos could reduce heart rate and perceived stress in college students. Twenty participants were shown either an ASMR video or a control video. Before …

Mobile Phone Mindfulness: Effects Of App-Based Meditation Intervention On Stress And Hrv Of Undergraduate Students, Samuel M. Degenhard

Modern Psychological Studies

Since the COVID-19 pandemic, stress has increased exponentially in undergraduate populations. The current study sought to determine the efficacy of an eight-week relaxation intervention, using a free meditation app to reduce perceived stress and increase baseline heart rate variability (HRV) of undergraduate students, compared to using a traditional relaxation intervention across the same period. Participants (N = 14) were randomized into either a meditation app group or self-directed diaphragmatic breathing group and were instructed to engage in their respective relaxation technique ten minutes daily for eight weeks. Pre- and post-intervention differences in perceived stress and HRV were examined, along with …

Examining The Role Of High School Spiritual Practice And Ways Of Coping In Levels Of Anxiety Among College-Aged Women, Madison Harris, Oyenike Balogun-Mwangi

Modern Psychological Studies

Utilizing an online survey, this study aimed to examine the extent to which the encouragement of spiritual practice in high school, current endorsement of daily spiritual experience, and ways of coping, predict anxiety levels among college-aged women (N = 140). Participants were recruited through the use of snowball sampling via email and flyers posted around campus. Data was collected via a demographic questionnaire and self-report measures assessing ways of coping, religiosity, and levels of anxiety among the sample. Results of a multiple regression analysis showed that focusing on and venting of emotions, behavioral disengagement, mental disengagement, and the encouragement of …

Effects Of A Brief Exposure To Nature Or Social Media On Psychological Well-Being, Megan C. Hall, Samantha L. Mcmichael, Virginia Sy Kwan

Modern Psychological Studies

Social media has enhanced our ability to connect with each other globally; however, social media is not necessarily beneficial. Given the potential negative impact of social media use on psychological well-being, it is important to identify resources that may buffer this impact. One resource may be exposure to nature. Participants exposed to nature scenes experienced less negative affect compared to those exposed to social media. Those who spent more time outside tended to experience decreased negative affect when they viewed both social media and nature photos, but when viewing only social media, they experienced increased negative affect. Relations between humans, …

Dyadic Aerobic Exercise As Treatment For Social Anxiety: A Randomized Control Trial, Dylan M. Palmer

Modern Psychological Studies

This study examines the effects of aerobic exercise, especially dyadic aerobic exercise, on levels of social anxiety. Investigated, also, is the extent to which dimensional moderators of social anxiety play an intermediary role in levels of social anxiety. The present study follows a between subjects, repeated measures, randomized control trial design. All experimental data was derived from self-report measures conducted prior to, during, and at the conclusion of a two-week aerobic exercise regimen. Data analysis was conducted via means comparisons, within subjects and between groups, on various metrics. Our results suggest a greater efficacy of dyadic aerobic exercise over both …

The Functional Role Of Context In Action Perception And Understanding Social Situations, Anjali -

Modern Psychological Studies

This study investigated the influence of understanding the perception of action congruency in animated video actors. The study employed a 2 x 2 pre-post design with the type of training (relevant, irrelevant) as a between-subjects design. The present study aimed to address whether the presence (versus absence) of contextual information affected an individual’s ability to make sense of social interactions, and if relevant contextual cues aided an individual’s perspective of social situations. Participants consisted of 80 undergraduate students at the University of British Columbia. Action congruency is the level of social coordination between two figures. Perceptions of action congruency was …

Intermel: An International Biorepository And Clinical Database To Uncover Predictors Of Survival In Early-Stage Melanoma, Jessica M Kenney, Cecilia Lezcano, James S Wilmott, Anne E Cust, Richard A Scolyer, Graham J Mann, Tim K Lee, Hazel Burke, Valerie Jakrot, Ping Shang, Peter M Ferguson, Tawny W Boyce, Jennifer S Ko, Peter Ngo, Pauline Funchain, Judy R Rees, Kelli O'Connell, Honglin Hao, Eloise Parrish, Kathleen Conway, Paul B Googe, David W Ollila, Stergios J Moschos, Eva Hernando, Douglas Hanniford, Diana Argibay, Christopher I Amos, Jeffrey E Lee, Iman Osman, Li Luo, Pei-Fen Kuan, Arshi Aurora, Bonnie E Gould Rothberg, Marcus W Bosenberg, Meg R Gerstenblith, Cheryl Thompson, Paul N Bogner, Ivan P Gorlov, Sheri L Holmen, Elise K Brunsgaard, Yvonne M Saenger, Ronglai Shen, Venkatraman Seshan, Eduardo Nagore, Marc S Ernstoff, Klaus J Busam, Colin B Begg, Nancy E Thomas, Marianne Berwick, Intermel Consortium

Faculty, Staff and Students Publications

INTRODUCTION: We are conducting a multicenter study to identify classifiers predictive of disease-specific survival in patients with primary melanomas. Here we delineate the unique aspects, challenges, and best practices for optimizing a study of generally small-sized pigmented tumor samples including primary melanomas of at least 1.05mm from AJTCC TNM stage IIA-IIID patients. We also evaluated tissue-derived predictors of extracted nucleic acids' quality and success in downstream testing. This ongoing study will target 1,000 melanomas within the international InterMEL consortium.

METHODS: Following a pre-established protocol, participating centers ship formalin-fixed paraffin embedded (FFPE) tissue sections to Memorial Sloan Kettering Cancer Center for …

Ai-Powered Discovery Of A Novel P53-Y220c Reactivator, Praveen Neeli, Xinfang Yu, Aram Davtyan, Ken Young, Yong Li

Faculty, Staff and Students Publications

Introduction

The p53-Y220C mutation is one of the most common mutations that play a major role in cancer progression.

Methods

In this study, we applied artificial intelligence (AI)-powered virtual screening to identify small-molecule compounds that specifically restore the wild-type p53 conformation from p53-Y220C. From 10 million compounds, the AI algorithm selected a chemically diverse set of 83 high-scoring hits, which were subjected to several experimental assays using cell lines with different p53 mutations.

Results

We identified one compound, H3, that preferentially killed cells with the p53-Y220C mutation compared to cells with other p53 mutations. H3 increased the amount of folded …

Transformations Between Rotational And Translational Invariants Formulated In Reciprocal Spaces

Faculty, Staff and Students Publications

Correlation functions play an important role in the theoretical underpinnings of many disparate areas of the physical sciences: in particular, scattering theory. More recently, they have become useful in the classification of objects in areas such as computer vision and our area of cryoEM. Our primary classification scheme in the cryoEM image processing system, EMAN2, is now based on third order invariants formulated in Fourier space. This allows a factor of 8 speed up in the two classification procedures inherent in our software pipeline, because it allows for classification without the need for computationally costly alignment procedures. In this work, …

Journal Of Undergraduate Research Information Page, Division Of Research And Economic Development

The Journal of Undergraduate Research

No abstract provided.

Structural And Magnetic Properties Of Heusler Alloys: Fecrmn1-Xvxal (X = 0, 0.5, 0.75), Jax Wysong, Gavin Baker

The Journal of Undergraduate Research

Heusler alloys are important to investigate due to their multiple interesting properties including half-metallicity and spin-gapless semi conductivity. Materials exhibiting these properties are desired for spin-transport-based devices. These devices provide the storing and delivering of information through the utilization of the spin property of electrons. The magnetic and electronic band properties of these alloys can be modified by tuning the elemental composition. This work investigates structural and magnetic properties of the three Heusler alloys FeCrMnAl, FeCrMn_0.5V_0.5Al, and FeCrMn_0.25V_0.75Al. It was found that all three alloys crystallize in cubic crystal structure with an …

Editorial: Biological Drivers Of Vector-Pathogen Interactions – Vol Ii

Faculty, Staff and Students Publications

No abstract provided.

Editorial: The Regulatory Immune System As A Target To Improve Adjuvants And Novel Vaccines

Faculty, Staff and Students Publications

No abstract provided.

Dantrolene Inhibits Lysophosphatidylcholine-Induced Valve Interstitial Cell Calcific Nodule Formation Via Blockade Of The Ryanodine Receptor, William J West, Jennifer P Connell, K Jane Grande-Allen

Faculty, Staff and Students Publications

Calcific aortic valve disease (CAVD), a fibrocalcific thickening of the aortic valve leaflets causing obstruction of the left ventricular outflow tract, affects nearly 10 million people worldwide. For those who reach end-stage CAVD, the only treatment is highly invasive valve replacement. The development of pharmaceutical treatments that can slow or reverse the progression in those affected by CAVD would greatly advance the treatment of this disease. The principal cell type responsible for the fibrocalcific thickening of the valve leaflets in CAVD is valvular interstitial cells (VICs). The cellular processes mediating this calcification are complex, but calcium second messenger signaling, regulated …

How Do Cultural Norms Shape Healthy Eating In African Americans? The Role Of Cultural Congruence And Mindsets Of Health In Healthy Eating Intentions Among African American College Students, Danyel Smith

Theses and Dissertations

Targeting dietary behaviors is a predominant strategy to reduce rates of obesity among African Americans, across the lifespan. Notably, dietary behaviors are shaped by social, cultural and environmental affordances. This study integrated Theory of planned behavior (TPB), identity-based motivation, and mindset theory to unearth cultural mechanisms that inform motivations to eat healthy among African American college students. This project employed a cross-sectional (Study 1) and experimental design (Study 2) to contextualize the antecedents of intentions to eat healthy among African American college students. Recruitment occurred via university-wide digital channels. Eligible participants: were 18+ years; Black/African American; were undergraduate students; and …

A Systematic Review Of Treatments For Misophonia, Andrew G Guzick, Wayne K Goodman, Eric A Storch

Faculty, Staff and Students Publications

Research into misophonia treatments has been limited and it is unclear what treatment approaches may be effective. This systematic review extracted and synthesized relevant treatment research on misophonia to examine the efficacy of various intervention modalities and identify current trends in order to guide future treatment research. PubMed, PsycINFO, Google Scholar, and Cochrane Central were searched 4using the keywords "misophonia," "decreased sound tolerance," "selective sound sensitivity," or "decreased sound sensitivity." Of the 169 records available for initial screening, 33 studied misophonia treatment specifically. Data were available for one randomized controlled trial, one open label trial, and 31 case studies. Treatments …

Arhs 4973 Seminar In Art History, Ana Pulido Rull

All Syllabi

No abstract provided.

Arhs 5573 Artists Of New Spain, Ana Pulido Rull

All Syllabi

No abstract provided.

Arhs 5973 Seminar In Art History, Ana Pulido Rull

All Syllabi

No abstract provided.