Digital Commons Network^™

Histological Quality Of Immersion Vs Intravascular Fixation Of Fresh Tissue, Andrew Hodges, Bright Danso, Gretchka Mair, Kingsley Ampong, Rebekah Satalino

Liberty University Research Week

Tissue fixation is a fundamental determinant of histological quality, preserving cellular architecture through protein cross-linking and enzymatic inactivation [6]. Among fixation approaches, intravascular (perfusion) and immersion methods differ significantly in mechanism and outcomes. Perfusion fixation rapidly distributes fixative via the vascular system, often producing more uniform preservation, whereas immersion fixation relies on diffusion, which may result in delayed penetration and heterogeneous tissue quality [5]. Despite these limitations, immersion-based preservation remains widely used in anatomical education and commercial specimen preparation due to its simplicity and cost-effectiveness [2]. Reports suggest that fixation quality can influence analyses, including morphology, antigenicity, and staining reliability, …

Effects Of Parental Communication On Alcohol Use And Self-Esteem As A Mediating Variable, Alanna Hartman

Research & Creative Achievement Day

Alcohol abuse has become a problematic phenomenon among young adults. Previous studies have found that parental communication with low warmth leads to greater risk for alcohol abuse later in life. We predict there is going to be a positive correlation between negative parental communication and alcohol abuse. Self-esteem has also been shown to have a relationship with alcohol abuse in previous research. We hypothesize that self-esteem would negatively correlate with alcohol abuse in the current study. Additionally, the literature suggests a relationship between self-esteem and parental communication. Given the relationships among these variables, we predict that self-esteem would partially or …

Beyond Caseloads And Calendars: Measuring Staff Satisfaction In Treatment Court, Ariana R. Huntington

Research & Creative Achievement Day

Background and Purpose: Treatment courts are specialized programs designed to divert individuals from incarceration while supporting recovery and rehabilitation. With more than 4,000 treatment courts operating nationwide and serving over 150,000 individuals annually, they represent a critical component of the criminal justice system. Treatment court staff may be particularly vulnerable to stress due to sustained exposure to complex substance use cases and systemic, administrative, and team-related demands. Assessing staff well-being is therefore essential, as it has implications for court effectiveness, workforce stability, and overall system functioning. Despite this importance, limited research has examined the experiences of treatment court professionals. The …

The Impact Of Early Skin-To-Skin Contact On Neurodevelopmental Outcomes In Preterm Infants, Ashia Meister

Research & Creative Achievement Day

Preterm infants face significant neurodevelopmental risks due to the interruption of late gestation brain maturation. Early skin to skin contact has emerged as a low cost intervention that supports sensory regulation, physiological stability, and neural development. This honors project synthesizes current evidence on how early skin to skin contact influences cognitive, motor, language, and socio emotional outcomes in preterm infants and translates these findings into an educational presentation for pre licensure nursing students. Across studies, early and sustained skin to skin contact is associated with improved brain activity, behavioral organization, and developmental scores in infancy, with additional evidence of structural …

Molecular Basis Of 24-Methyl Cholesterol As An Anti-Renal Clear Cell Carcinoma Agent In The Context Of Altered Cellular Glucose Metabolism, Josiah Chung, Merritt Smith, Zachary Wang

Liberty University Research Week

Cancer remains a major global cause of mortality, with kidney cancer representing a significant portion of newly diagnosed cases each year worldwide and in the United States. In Virginia alone, more than one thousand new kidney cancer cases are reported annually. The majority of these cancers are classified as renal cell carcinoma (RCC), with clear cell renal cell carcinoma (ccRCC) accounting for roughly 70% of diagnoses. ccRCC tumors exhibit substantial metabolic reprogramming that supports rapid proliferation and survival under fluctuating nutrient conditions. Because of this metabolic dependence, targeting pathways involved in glucose uptake and cellular energy production has emerged as …

Comparison Of Total Distance And Sprint Distance Between Positions Of Division Ii Female Soccer Players, Tamas Sebestyen, Jonathan P. Bayer

Research & Creative Achievement Day

Introduction: To manage player health, minimize injury, and optimize performance in NCAA Division II soccer, this study analyzed positional demands using GPS technology. The findings provide insights into enhancing training plans and recovery based on specific positions. Methods: NCAA Division II female soccer players were tracked during sixteen in-season competitions using 10 Hz GPS wearable technology. Players were grouped into tactical roles including Wing Backs (WB), Center Backs (CB), Defensive Midfielders (6), Attacking Midfielders (10), and Forwards (9). Key metrics analyzed included Total Distance (TD), Total Sprint Distance (TSD), and Distance per Minute (D/M). Results: Forwards (9) and attacking midfielders …

Development Of A Laboratory Aquaculture System For Education And Research: Experimental Culture Of Fathead Minnows, Jill Crunkilton

Liberty University Research Week

As global fish consumption rises and wild stocks continue to decline, aquaculture has become essential for meeting protein demands sustainably. To prepare college-level graduates for careers in this expanding field, hands-on education in aquaculture systems and fish husbandry is critical. This project focuses on the development of a laboratory aquaculture system centered on the experimental culture of fathead minnows (Pimephales promelas), a model species widely used in aquatic research and toxicity testing. The system will serve dual purposes: (1) providing students with experiential training in aquaculture techniques, including breeding, water quality management, and biosecurity; and (2) establishing a platform for …

Hargreaves Test On Formalin Injected Mice: A Neuropathic Pain Model, Caleb Mast

Liberty University Research Week

Neuropathic pain is a chronic condition resulting from nervous system injury or disease, commonly associated with multiple sclerosis, spinal cord injury and diabetes. Current mouse models rely on invasive surgical techniques such as spinal nerve ligation (SNL) or chronic constriction injury (CCI), which require specialized training, increase variability, and reduced accessibility. Previous studies in rats have shown that formalin injections can induce a persistent pain state and spinal molecular changes comparable to those observed in surgical models. This study investigated whether a single subcutaneous injection of 5% formalin is sufficient to produce neuropathic pain behaviors and nervous tissue changes CCI …

Virginia Stream Condition Index Score Of Benthic Macroinvertebrates In Opossum Creek¿, Ella Mason, Lance Jones, Sean Genota

Liberty University Research Week

Recently, Lake Hydaway, an artificial lake in Lynchburg, Virginia, was expanded from 6 to 31 acres. The expansion project included the demolition of the old dam, excavation of the lakebed, construction of a new dam, and the removal of riparian vegetation directly downstream of the dam. Opossum Creek, a first-order stream and tributary flowing into and out of the lake, is at risk of being disturbed by the expansion, which has the potential to impact its freshwater ecosystem. Through observing communities of benthic macroinvertebrates, insights can be made into the health of aquatic environments. This research selected four sites along …

Exploring The Mandelbrot Set In Real Algebras, Shane Weimar

Liberty University Research Week

The Mandelbrot set is a fractal in the complex plane. Its boundary is chaotic, and very difficult to determine completely. In recent years, mathematicians have put considerable effort into understanding the Mandelbrot set, since understanding the Mandelbrot set would give insight into how fractals and chaos work in general. However, very little research has been conducted into the Mandelbrot set in abstract algebras. This research will categorize some of these algebras and compute the Mandelbrot set in them.

When Microbiology Meets Public Health: Exploring Metabolites From Dictyostelium Discoideum For Infection Control, Rebekah Figuereo

Liberty University Research Week

Background: The social amoeba, slime mold, formally known as Dictyostelium discoideum, produces novel chlorine-containing antimicrobial compounds that can be used to improve antimicrobial resistance by targeting and preventing bacterial spread by inhibiting bacterial growth. This bridges microbiological discoveries with public health applications, thereby strengthening infection control strategies. Current research connects the slime mold to infection recovery/intervention/control.1

Methods: A systematic review of peer-reviewed journal articles, biochemical databases, and experimental findings was conducted. Scientific databases featured PubMed, Web of Science, Google Scholar, Chemical Abstracts Service, ScienceDirect, and Scopus.

Results: Metabolites produced by Dictyostelium discoideum demonstrated antimicrobial activity by inhibiting bacterial growth, including …

The Inhibitory Effects Of Fluorophenol On Cytochrome P450 2a6, Andrew Hodges

Liberty University Research Week

The cytochrome P450 family is composed of several metabolic enzymes found in the liver that are responsible for the processing and excretion of many xenobiotics and toxins. Cytochrome P450 2A6 (CYP2A6) is of pharmacological interest because of its key role in nicotine metabolism. Because of this, it is considered a primary target for inhibition as a potential strategy for smoking cessation and curtailing cigarette addiction. However, such a pharmacological agent is still being developed as the enzyme kinetics of CYP2A6 are not fully understood. It is also the only cytochrome that converts coumarin, a substance found in many plants, to …

Association Between Preexisting Chronic Conditions And Hospital Outcomes Among Pediatric Trauma Patients In The United States, 2000-2019, Grace Sibert

Liberty University Research Week

The prevalence of chronic disease among children in the United States has increased substantially over the past two decades. Children with chronic disease experience higher morbidity, mortality, and healthcare utilization, disparities that may be amplified following traumatic injury. However, nationally representative longitudinal data examining these associations remains limited. We conducted a retrospective cohort study using the Healthcare Cost and Utilization Project Kids’ Inpatient Database (HCUP-KID) from 2000 to 2019. Pediatric patients (=18 years) hospitalized for traumatic injury were identified using ICD-9-CM and ICD-10-CM codes. Chronic conditions were classified using the HCUP Chronic Condition Indicator and grouped into major diagnostic categories. …

The Role Of Medical Nutrition Therapy In Gestational Diabetes Mellitus: A Narrative Review, Alexis Snyder

Liberty University Research Week

Gestational Diabetes Mellitus (GDM) is type of high blood sugar with an onset during pregnancy that leads to insulin resistance. Annually, 5-9% of pregnancies are affected by gestational diabetes. GDM frequently causes excessive birth weight, breathing problems, preeclampsia, an increased risk of developing type 2 diabetes and hypoglycemia following pregnancy. Medical Nutrition Therapy (MNT) is the primary treatment for GDM, but actual dietary guidelines tend to differ between various studies. This narrative literature review aims to synthesize current studies on the effectiveness of MNT for the management and outcome of gestational diabetes. Specifically looking at pathophysiology of the disease, blood …

Exploration Of Preservative-Surfactant Aggregation Effects On Biologic Drug Formulations, Joseph Turmelle

Liberty University Research Week

A key challenge in the development of injectable drug formulations is the need for multi-dose administration, which increases the risk of bacterial contamination. To reduce this risk, preservatives such as phenol (PhOH) and benzyl alcohol (BzOH) are commonly added to formulations. However, preservatives can aggregate with other critical excipients, particularly surfactants such as polysorbate 20 (PS20). This aggregation leads to physical instability, often observed as turbidity or precipitation. Previous work has shown that preservatives induce the formation of large, unstable aggregates with surfactants at pharmaceutically relevant concentrations. The purpose of this study is to characterize and understand this phenomenon of …

Exploring The K-12 Educational Experiences Of First-Generation Hispanic Undergraduate Students, Stephanie Hernandez-Lopez

Liberty University Research Week

Research Question: This qualitative study examines how first-generation Hispanic undergraduate students perceive their K-12 educational experiences and how these shaped their transition into higher education. Method: Through semi-structured interviews with four participants, the research identifies recurring themes, including parental involvement, language barriers, access to resources, motivation, and preparedness for college. These insights contribute to understanding systemic factors behind the achievement gap and inform strategies for more equitable educational support. Conclusion: Overall, the findings show that first-generation Hispanic students’ college readiness is shaped by the combined effects of limited early academic rigor, inconsistent school–family communication, and assumptions about home academic support. …

Honoring Survivors’ Wholeness: Recommendations For University Offices Of Wellness, Maeve Jillian King

GS4 Student Scholars Symposium

Rates of child abuse are nationally significant, especially after considering how much violence goes unreported. Many college students have experienced sexual violence prior to arriving on campus, where incidents of sexual victimization are prominent. With this in mind, how can university offices of wellness support survivors wherever they are in their journey of survivorship? Previous research rarely considers both realities of victimization, but displays large concerns surrounding survivor’s mental health and educational obtainment. Additionally peer and social support play significant roles in survivor outcomes. This interdisciplinary literature review examines current university practices, mental health realities, and impacts of culture on …

Thinking Under Pressure: Does Mindset And Mood Affect Cognitive Performance?, Pamela Kplivi, Hannah Nowicki, Emmy Carmichael, Charlie Guri, Abigail Blanda, Brandon Sookkasem, Shayne Alexander, Hope Williams, Gabriella Tossah, Meeraben Patel, Michael Woodcock, Virginia Wickline

GS4 Student Scholars Symposium

Cognitive performance, particularly on tasks requiring creative problem-solving, can be influenced by both individual and situational factors. Prior research highlights intrinsic beliefs about intelligence and external factors such as mood states as determinants of problem solving outcomes (Baumeister & Vohs, 2016; Okon-Singer et al., 2015). The present study utilizes a 2 x 3 between-subjects experimental design to examine how mindset (growth vs. fixed) and temporary mood state (positive, neutral, negative) interact to shape performance on a creative problem solving task. Mindset is assessed using the Implicit Theories of Intelligence Scale (ITIS; Dweck, 1999), cognitive performance is measured using a shortened …

What Is Philosophy For? Reading Wittgenstein After Cavell, Maggie L. Zhang

2026 Claremont Colleges Library Undergraduate Research Award

This literature review examines two major strands of Cavellian scholarship on Wittgenstein, arguing that their relative separation has obscured the insights each offers the other. Cavell’s “therapeutic” reading of Wittgenstein understands his philosophical project not as a theory of language but as an activity aimed at dissolving the philosophical fantasy of such a theory. This approach has been taken up along two largely distinct lines of inquiry: one focused on the Tractatus and the debate between substantial and austere views of nonsense, and another centered on the Philosophical Investigations and its relation to ordinary language philosophy, particularly in light of …

Systemic Barriers To Parental Involvement In Immigrant Families: Impact On Children’S Academic Outcomes, Ama Jane Baffoe

Undergraduate Research and Engagement Symposium

This literature review examines how parental involvement and systemic barriers influence children’s academic outcomes, specifically within immigrant families. By analyzing research on language proficiency and work schedules, this study identifies how these factors limit parental participation in school-based activities. Findings indicate that while parental involvement consistently correlates with academic achievement and emotional stability, current school systems often disadvantage immigrant families facing these barriers. The review concludes that schools must develop more inclusive involvement strategies to eliminate educational inequalities and better support the success of students from diverse backgrounds.

Effects Of Exercise And Chemotherapy Treatments On Survival And Climbing Activity In Drosophila Melanogaster With Different Mitochondrial Genotypes., Amber A. Haines

Research & Creative Achievement Day

Mitochondrial variation plays a role in energy production, physical performance and responses to physiological stress. This study investigated how Drosophila melanogaster, fruit flies, mitochondrial differences and exercise affected survival under the cisplatin and climbing abilities. Fruit flies with different mitochondrial genotypes were assigned to exercise and non-exercise groups. These groups were then split and assigned to either sugar or cisplatin, a chemotherapy drug. Survival rates and climbing ability, a measure of neurodegeneration, were monitored after the treatment. This study will provide information about how mitochondrial variation and exercise can influence responses to environmental and chemical stress.

Public Health Book Club, Ashia Meister, James W. Durst, Ameila Beyer, Kelly K. Freymiller, Julia I. Kunz, Jaci M. Winchell, Josephine M. Sandquist, Chloe F. Sand

Research & Creative Achievement Day

Introduction: This project describes the development and implementation of a book club focused on population health topics to promote learning, discussion, and community engagement. A public library is a safe space to host book club meetings due to its non-intimidating environment. All members of the community are welcome to participate. A book club was hosted on campus for members of the nursing cohort to attend. With a focus on public health, these book clubs build awareness, critical thinking, and community engagement around population health issues. Purpose: The promotion of a book club can improve health literacy in the community by …

Deep Tissue Massage-Induced Muscle Damage Associated With Delayed Onset Muscle Soreness (Doms), Stress, And Rhabdomyolysis, Lily M. Ekert, Ella R. Halopka, Micah Maddio, Marisa Wood, Bailey Kerkow, Logan Murphy, Ashley Wise

Research & Creative Achievement Day

Deep tissue massage is a common treatment method used to aid in muscle recovery, reduce pain, and promote overall physical well-being. However, there is limited research explaining its biochemical effects at a cellular level, particularly in relation to muscle damage and systemic inflammation. Severe cases of muscle tissue breakdown are Rhabdomyolysis, which is discussed with an emphasis on clinical evidence rather than biochemical aspects. The goal of this study is to determine whether deep tissue massages cause cellular damage and tissue inflammation. This testing will be done through quantitative measurements of biomarkers within the bloodstream. In previous studies, four specific …

Publishing Satori Literary Journal, Shaela Eriksen, Jade Mcelmury, Reagan Roesler, Camden Mcdonald, Jade Mcelmury, Elena Armstrong, Lydia Domaille, Jenifer Frick, Linda Hang, Eva Hodnick, Sarah Huderle, Dylan Jackson, Charlie Lund, Kendra Mcclure, Linda Moua, Callie Sahlstrom, Allen Wedekind

Research & Creative Achievement Day

This poster presentation will cover how ENG 324 created Winona State University's Literary Art Journal, Satori, and its companion, Irotas. Both journals feature works of poetry, fiction, non-fiction, and photo submissions. Satori was created by students in the class who worked to solicit submissions and market the journal across campus.  This presentation will also cover the production process and the many logistical aspects of publishing a literary journal.

The process of soliciting submissions included a variety of social media and traditional formats to advertise the Satori submissions. While receiving submissions, the class studied the legal and production processes of book …

The Impact Of Social Media On Voter Turnout, Madeline M. Hutchison

Research & Creative Achievement Day

I will be observing how the use of social media affects voter turnout in the presidential election. Using data collected by the American National Election studies I compare data on how often respondents are on social media, and if they voted in the most recent election. I hope to find that an increased use of social media leads to citizens being more likely to vote in the presidential election, especially if they get political information from these social media sites. My main hypothesis is that more access to social media leads to a higher voter turnout in American presidential elections, …

Natural Products As Multi Drug-Multi Target Therapeutics - From The Pharmacological Proof To New Approaches For Quantitative Quality Control, Olaf Kelber

Oxford ICSB

In the two decades since the mode of action of herbal medicinal products has been characterized as the Multi Target action of Multi Drug combinations [1,2, 3], the body of evidence supporting the general applicability of this principle to herbal health products has been exponentially increasing.  Key studies describing this principle, based on a wide range of pharmacological models, have been conducted in STW 5 and STW 5-II, herbal combinations used in the treatment of disturbances of the gut-brain interaction (DGBIs) as e.g. upset stomach and irritable bowel syndrome [2, 4]. They allow to characterize the contribution of each combination …

Medicinal Plants And One Health Drug Discovery: Plectranthus Abietanes As P-Glycoprotein Modulators, Patricia Rijo

Oxford ICSB

Cancer remains a major global health challenge, with multidrug resistance (MDR)—frequently driven by P-glycoprotein (P-gp) overexpression—significantly limiting the effectiveness of chemotherapy. Within a One Health perspective, Africa, home to five major medicinal biodiversity hotspots, represents an underexplored reservoir for natural products–based drug discovery. Among this rich flora, the genus Plectranthus (Lamiaceae) emerges as a particularly promising source of bioactive abietane diterpenes. In this work, the abietane diterpene 7α-acetoxy-6β-hydroxyroyleanone (Roy), isolated from Plectranthus grandidentatus Gürke, exhibited pronounced cytotoxic activity against several cancer cell lines. To enhance its pharmacological profile, a series of Roy ester derivatives was synthesized and evaluated for their …

Expanding Natural Product Diversity Through Biotransformation, Emerson Queiroz

Oxford ICSB

Over the past decade, natural product research has undergone a methodological revolution [1]. Modern approaches now integrate advanced metabolite profiling techniques for compound annotation and prioritization, together with high-resolution chromatographic methods that enable seamless transition from analytical to preparative scales [2]. These tools have facilitated the detection and identification of minor bioactive constituents. Nevertheless, plant extracts typically contain abundant common scaffolds with limited relevance for drug discovery. In this context, enzymatic biotransformation emerges as a promising strategy to enhance chemical diversity and unlock new structural space. Two complementary biotechnological approaches have been developed: enzymatic transformation using fungal secretomes (crude extracellular …

India: Live Model Portraiture, Jennifer Trahant

Liberty University Research Week

India: Live Model Portraiture explores how charcoal can balance accurate likeness with expressive mark-making. While careful attention to proportion, value, and line captures the model’s physical presence, looser marks in the background add movement and begin to blur the boundary between the figure and its surroundings. Rather than aiming for perfect realism, the drawing allows moments of abstraction to bring more life and energy into the subject. This piece shows how charcoal portraiture can move beyond simple replication to create a stronger sense of body and spirit.

The Role Of Group Guidance With Psychodrama In Promoting Self-Adjustment: Does It Really Work For Adolescents?, Hanifa Salsa Bila, Dian Ari Widyastuti, Sri Tutur Martaningsih, Agungbudiprabowo Agungbudiprabowo, Taquddin Abd Mukti

Buletin Konseling Inovatif

This study aimed to examine the effectiveness of group guidance using psychodrama techniques in improving self-adjustment among students. The study employed a quantitative approach with an experimental research design, specifically a pretest–posttest control group design. The participants consisted of ten students, divided into an experimental group of five students and a control group of five students. The experimental group received group guidance with psychodrama techniques, while the control group received treatment as usual. The research participants were selected using a simple random sampling technique. Data were collected using a self-adjustment scale, which had been analyzed for validity and reliability using …