Digital Commons Network^™

Defining The Qualities Of A Surgical Resident Who "Gets It": A Qualitative Analysis Of Faculty And Resident Perceptions, Shaleen V Sathe, Ravi R Agrawal, Jennifer Yu, Paul E Wise, Michael Awad, Kevin Y Pei

2020-Current year OA Pubs

BACKGROUND: The phrase "getting it" is frequently used in surgical trainee assessment, yet its meaning remains undefined. This study explores how residents and faculty define the concept and whether perceptions align.

METHODS: Semi-structured interviews were conducted with 11 residents and 13 faculty at a single institution and analyzed using reflexive thematic analysis.

RESULTS: Residents described "getting it" as clinical competence, social awareness, feedback responsiveness, and team integration, while noting challenges with interpreting implicit expectations and the influence of faculty bias. Faculty described "getting it" as a gestalt recognition of initiative, insight, and sound clinical judgment. Both agreed that the concept …

Medical Simulation In Toxicology: Enhancing Clinical Competence, Decision Making And Patient Care In Resource-Limited Settings, Rakesh Ghimire, Anjana Thapa, Sanjeev Kharel, Shristi Kharel Ghimire, Rabin Basnet, Farshad Mazda Shirazi, Allan J. Hamilton

Research outputs 2022 to 2026

Medical simulation has emerged as a transformative approach in toxicology education. By providing immersive, hands-on experience, simulation enhances learner engagement, critical thinking, and long-term knowledge retention while offering a safe environment to practice clinical decision-making without jeopardizing patient safety. Despite these advantages, the integration of simulation-based training remains limited in low-and middle-income countries (LMICs) due to resource constraints, lack of standardized curricula, and limited access to high-fidelity simulators. Additionally, little research has explored its optimal application in these settings. This review explores available evidence regarding the effectiveness of medical simulation in the diagnosis and treatment of toxicological emergencies in LMICs. …

Adapt-On-Demand: Enabling Flexible And Scalable Adaptive Radiotherapy Through Workflow Automation, Sean Domal, Min Geon Choi, Justin Visak, Ruiqi Li, Taoran Li, Boon-Keng Kevin Teo, Xiaodong Zhao, Matthew Schmidt, Eric Laugeman, David Parsons, Yang Kyun Park, Shahed Badiyan, David Sher, Mu-Han Lin

2020-Current year OA Pubs

PURPOSE: CT-guided adaptive radiotherapy (CTgART) offers significant clinical benefits, but its utilization is often limited by resource demands and rigid workflows. This study presents a flexible and scalable "Adapt-on-Demand" (AOD) framework that integrates the adaptive capabilities of the Varian Ethos platform with the high-throughput IGRT delivery of the Varian Halcyon, supported by automated scripting.

METHODS: We developed an end-to-end dual-platform workflow that dynamically transitions between ART and IGRT delivery based on patient needs. Key components include Eclipse Scripting API (ESAPI) automation to streamline adapted plan ingestion from the Ethos Treatment Planning and Management System (TPMS) export directory, compatibility conversion for …

Preterm Birth Increases Susceptibility To Hyperglycemia-Induced Kidney Injury With Sex-Specific Differences In Structural And Molecular Responses, Rachel K Dailey, Aleksandra Cwiek, Logan C Hamil, Sage Timberline, Ayyappa Kumar Sista Kameshwar, Masako Suzuki, Jaya Isaac, Kimberly Deronde, Mark Conaway, Kevin M Bennett, Edwin J Baldelomar, Matthew R Hoch, Kimberly J Reidy, Jennifer R Charlton

2020-Current year OA Pubs

BACKGROUND: Preterm birth increases the long-term risk of diabetes and chronic kidney disease (CKD), yet its impact on diabetic kidney disease (DKD) is unclear. We previously showed that male preterm mice with diabetes develop early features of DKD, including reduced podocyte density, decreased renin expression, activation of angiogenesis pathways, and impaired endothelial-podocyte signaling. Here, we examine whether preterm birth similarly accelerates DKD progression in female mice and compare structural and transcriptomic outcomes in the females to the prior male cohort to assess sex-specific differences.

METHODS: Preterm mice were delivered by Caesarean section at 19 days post conception (dpc) and term …

Evaluation Of Iron-Phosphate Glass–Ceramic Waste Form For Electrorefiner Salt Waste Simulant Dechlorinated With Phosphoric Acid, Harmony Werth, Paige Murray, Lucas Greiner, Jade Beland, Charmayne Lonergan, Brian Riley, Krista Carlson

Materials Science and Engineering Faculty Research & Creative Works

The importance of glass and glass–ceramic nuclear waste forms has been reaffirmed in recent years by the growing interest in nuclear power as a reliable energy source. Determination of processing methods for the disposal of halide-containing wastes will be essential for the advancement of nuclear technologies such as non-aqueous fuel reprocessing. Phosphate-based dechlorination and subsequent vitrification of radioactive salt waste into an iron-phosphate waste form have been identified as a potential processing scheme for electrochemical processing waste. The impact of H₃PO₄-based dechlorination of complex salt mixtures on the vitrification process and structure of the final iron-phosphate …

Effect Of Composition On Grain-Boundary Chemistry And Fracture Behavior In High-Entropy Carbides, Caleb Schenck, Marium Mostafiz Mou, Elizabeth Pritchett, Fu Yun Tsai, Josephine Hartmann, Michael Lastovich, Sam Daigle, Kayla Yano, Matthew J. Olszta, Sanjit Bhowick, Elizabeth Kautz, Gregory E. Hilmas, William G. Fahrenholtz, Donald W. Brenner

Materials Science and Engineering Faculty Research & Creative Works

High-entropy carbides (HECs) are often treated as a single material class defined by configurational entropy; however, their properties are governed by composition-specific defects and grain-boundary chemistry. This study demonstrates that substituting a single element can qualitatively change grain-boundary structure and fracture behavior in HEC ceramics. Two HECs, (Cr,Hf,Ta,Ti,Zr)C (HEC-Cr) and (Hf,Ta,Ti,W,Zr)C (HEC-W), were examined via electron microscopy, atom probe tomography, and molecular dynamics simulations. Simulations predict preferential segregation of Cr, W, and Zr to grain boundaries. Experiments confirmed Cr enrichment at grain boundaries and the formation of W-rich nanograins along boundary networks. Mechanical testing revealed that these compositional differences translated …

Evaluating The Integration Of Bio-Based Waste Into Cement Production: A Pathway To Sustainable Building, Anja Terzić, Suzana Filipović, Adriana Peleš Tadić, Jelena Živojinović, Ivana N. Jelić, Nina Obradović, William G. Fahrenholtz

Materials Science and Engineering Faculty Research & Creative Works

Rapid urbanization has increased the demand for building materials, depleting natural resources used in cement production and prompting the use of alternative and waste materials. This research verifies that eggshell powder waste can fully replace limestone in clinker synthesis. Five clinkers were produced using eggshell powder, aluminum sources (bentonite, zeolite, fly ash, and kaolinitic–illitic clay), Fe-slag, and quartz sand, with mechanical preprocessing (10–30 min) before sintering at 1300 °C. Experimental tests assessed the effects of mix design and mechanical activation on clinkerization, phase formation, temperature, and mechanical properties. XRD, FTIR, and SEM/EDS confirmed consistent phase compositions and primary cement minerals. …

Selective Extraction Of Nickel And Cobalt From Limonitic Laterite Via Optimized Sulfation Roasting–Water Leaching And Solvent Extraction, Maryam Osali, Farid Ahani, Mohammad Reza Aboutalebi, Mandana Adeli, Javad Moghaddam, Saeid Karimi, Janaka Jayamini Wijenayake, Lana Alagha

Mining Engineering Faculty Research & Creative Works

Limonitic laterites typically contain low Ni and Co contents and significant impurities, making the development of technical and economically feasible processes challenging. To address this challenge, this study investigates and evaluates an integrated hydrometallurgical process comprising sulfation roasting, water leaching, and solvent extraction (SX) for the selective recovery of Ni and Co from limonite-type laterite. Response Surface Methodology coupled with a Central Composite Design (RSM-CCD) was employed as a statistical experimental design tool to efficiently optimize the sulfation roasting conditions. Under the optimal sulfation roasting conditions (temperature 703 °C), selective leaching efficiencies of 87.2% for Ni and 96.6% for Co …

In-Operando Imaging For Mechanistic Insights And Process Optimization In The Biofuel-Driven Combustion Synthesis Of Cement And Precursor Phases, Shubham Agrawal, Jeffrey J. Long, Aditya Kumar, Narayanan Neithalath

Materials Science and Engineering Faculty Research & Creative Works

Biofuel-based combustion synthesis (BCS) is a promising low-carbon pathway for decarbonizing cement production, providing an alternative to the fossil-fuel-driven clinkering process typically conducted at ∼1450 °C. Understanding microscale combustion mechanisms is essential to efficiently transfer biofuel-generated heat to cement precursors for targeted phase formation. Unlike previous studies focusing on macro-scale parameters such as fuel content/type, porosity, and holding temperature, this work provides mechanistic insights into microscale combustion behavior, linking microstructural phenomena with macro-scale processing conditions to guide parameter optimization. In-operando microscale imaging was employed to examine combustion wave propagation, spatio-temporal temperature evolution, and microstructural transformations within reactive pellets. Two combustion …

Strong And Ductile Additively Manufactured Ti-6al-4v Through Yttrium Inoculation, Saeid Alipour, Ji Young Kim, Min Seok Kim, Arezoo Emdadi, Ju Li

Materials Science and Engineering Faculty Research & Creative Works

The unique microstructural features and thermal cycles in alloys produced by additive manufacturing (AM) techniques have led to the emergence of a new paradigm in the design and development of alloys for performance-critical applications. Despite the inherent microstructural features of AMed parts, optimizing the porosity-microstructure while acquiring desired mechanical performance has been crucial yet challenging. Hence, in many legacy alloys, achieving a strength-ductility synergy in the as-built condition without applying post-heat treatment or hybrid processes is considered an arduous task. In this research, we aimed to tailor the microstructure of the legacy Ti-6Al-4V alloy in the as-built condition by implementing …

Atom Probe Tomography Investigation Of Gas And Solid Fission Product Superlattice In Neutron Irradiated U-10 Wt.% Mo Fuel, Maalavan Arivu, Andrew Hoffman, Anish Ranjan, Assel Aitkaliyeva, Yaqiao Wu, Brandon Miller, Mukesh Bachhav, Dennis Keiser, Jian Gan, Haiming Wen

Materials Science and Engineering Faculty Research & Creative Works

Body-centered cubic structured γ U-Mo fuels have been developed for high performance research reactors. The formation of Xe gas bubble superlattice (GBS) in irradiated U-Mo fuels reduces the volumetric swelling of the fuels. In this study, atom probe tomography (APT) was used to measure the characteristics of the Xe GBS, including chemical composition, number density, and volume fraction of the gas bubbles, as well as the characteristics of the solid fission products, in neutron irradiated U-10 wt.% Mo fuel. It was found that in the bubbles (∼2 nm in diameter) that form the GBS are enriched with Xe with depletion …

Dynamic Mechanical Insertion Analysis Of Gelatin Methacryloyl Microneedles Under Realistic Insertion Conditions, Moloud Amini Baghbadorani, Masoumeh Zargar, Abdellah Shafieian, Majid Tolouei-Rad

Research outputs 2022 to 2026

Despite the great potential of Gelatin Methacryloyl (GelMA) microneedles (MNs) for minimally invasive drug delivery and interstitial fluid extraction, their performance under realistic insertion conditions and across diverse geometrical and mechanical parameters has remained uncharacterized. In this study, dynamic and static finite-element analyses were conducted for the first time to compare three types of crosslinked GelMA MNs: conical, pyramidal, and tapered-conical with and without base support. Insertion force, von Mises stress, and safety factors were evaluated at insertion velocities of 2-6 m/s under varying crosslinking times and polymer concentrations. The tapered-conical geometry demonstrated the best overall mechanical reliability, combining moderate …

Maximal Motor Unit Firing Rates Decline With Amyotrophic Lateral Sclerosis Progression, Gabriel L. Fernandes, Lucas B.R. Orssatto, Matheus D. Pinto, Joao S. Henkin, Ehsan Shandiz, Pamela A. Mccombe, Robert D. Henderson, Gabriel S. Trajano

Research outputs 2022 to 2026

Objective: Amyotrophic lateral sclerosis (ALS) is characterised by progressive degeneration of upper and lower motor neurons and their motor units (MUs). MU loss is compensated by collateral sprouting and reinnervation of muscle fibres. There is limited information about the properties of these surviving MUs as these processes take place. High-density surface electromyography (HD-sEMG) decomposition enables non-invasive analysis of individual MU firing behaviour during maximal voluntary contractions and assess their changes with ALS progression. Methods: Thirty-nine individuals with ALS (24 men; mean age 63 ± 16 years) completed up to five visits (interval 20.0 ± 7.9 weeks). Tibialis anterior HD-sEMG recordings …

3d-Printed Cf-Pla Bone Plates With Metamaterial Structures: Design, Fabrication, And Mechanical Evaluation, Ani Daniel, Hamed Bakhtiari, Alireza Nouri, Barun K. Das, Muhammad Aamir, Majid Tolouei-Rad

Research outputs 2022 to 2026

This study presents the design, fabrication, and mechanical performance of carbon fiber-reinforced polylactic acid (CF-PLA) bone plates incorporating auxetic and non-auxetic metamaterial architectures. Four lattice-structured bone plates (re-entrant, rotating square, tetrachiral, and hexagonal) were evaluated for their flexural, tensile, and compressive properties. The specimens were fabricated using Fused Deposition Modelling (FDM). The tetrachiral structure demonstrated superior bending capacity, achieving a flexural stress of 17 MPa and a modulus of 1214 MPa. Under both tension and compression, it exhibited the highest strength (24.5 MPa and 40 MPa, respectively) and stiffness (1441 MPa in tension and 2352 MPa in compression), while the …

A Clinical Study Examining The Effects Of Dietary Nitrate On Urinary N-Nitrosamines, Catherine P. Bondonno, Michaela L. Sundqvist, Sujata Shinde, Kevin Croft, Jonathan M. Hodgson, Mattias Carlström, Eddie Weitzberg, Jon O. Lundberg

Research outputs 2022 to 2026

BackgroundInorganic nitrate from dietary sources has raised health concerns due to its possible conversion into carcinogenic N-nitrosamines, leading to strict regulations on nitrate concentrations in food and drinking water.ObjectivesIn this study, which was a part of a larger randomized controlled trial, we evaluated urinary excretion of N-nitrosamines in response to daily dietary nitrate intake over a 5-wk period using 2 different forms of nitrate administration.MethodsA total of 231 participants with mild hypertension were randomly assigned into 3 groups. Group 1 (n = 78) consumed vegetables low in nitrate along with a placebo capsule (300 mg potassium chloride). Group 2 (n …

Associations Between Source-Specific Nitrate And Nitrite Intakes And Metabolic Dysfunction-Associated Steatotic Liver Disease In Two Prospective Cohorts, Nicola P. Bondonno, Pratik Pokharel, Benjamin H. Parmenter, Liezhou Zhong, Dorit W. Erichsen, Jörg Schullehner, Kirsten Frederiksen, Cecilie Kyrø, Peter Fjeldstad Hendriksen, Jonathan M. Hodgson, Torben Sigsgaard, Christina C. Dahm, Anne Tjønneland, Alysha S. Thompson, Tilman Kühn, Aedín Cassidy, Anja Olsen, Catherine P. Bondonno

Research outputs 2022 to 2026

SummaryBackground and AimsDietary nitrate and nitrite may have source-dependent effects on liver health: plant-sourced nitrate may confer hepatoprotective benefits via its conversion to nitric oxide, whereas nitrate and nitrite from animal foods, processed meats, or contaminated drinking water may promote liver injury via their conversion to N-nitrosamines. We aimed to examine associations between source-specific nitrate and nitrite intakes and incident metabolic dysfunction-associated steatotic liver disease (MASLD) in two large cohorts. Secondary aims were to assess associations with liver MRI biomarkers and to evaluate whether nitric oxide-pathway gene variants modify associations with plant-sourced nitrate/nitrite.MethodsWe analysed 53,854 participants from the Danish Diet, …

A Systematic Review And Meta-Analysis On The Levels Of Supportive Care Needs In Adults With Cancer, Caroline B. Silveira, Rech, Maria Petropoulou, Pietro S. Rössler, Francine F. De Souza, Helena B. Böhmer, Amanda L. Giacomet, Richard Alejandro B. De Barros, Lucélia De C. De Barros, Vagner R.Z.B. Pereira, Nanci Da S.T. Junqueira, Pedro Lopez

Research outputs 2022 to 2026

Objective: To estimate the levels of supportive care needs among adults with cancer using the Supportive Care Needs Survey–Short Form 34 (SCNS-SF34) and to examine demographic, clinical, and treatment-related determinants. Methods: A systematic review and meta-analysis was conducted (CRD42024604977). Studies reporting SCNS-SF34 scores in adults with cancer were included. Searches were performed across six different databases (November 2024; updated August 2025). Random-effects meta-analyses were undertaken to estimate the pooled mean scores across the five SCNS-SF34 domains and total score. Subgroup and meta-regression analyses explored potential determinants. Results: Ninety-five studies (n = 32,493) were analysed. The unmet needs observed tended to …

Dynamic Load Assessment Of Pem Fuel Cell Systems Under Pid-Based Control Strategies For Sustainable Operation, Tarek Abedin, Paw, Normy Norfiza Abdul Razak, Chen Chai Phing, Yaw Chong Tak, Monowar Mahmud, Manzoore Elahi M. Soudagar, T. M. Yunus Khan, Mohammad Tariqul Islam, Mohammad Nur-E-Alam

Research outputs 2022 to 2026

Proton exchange membrane fuel cell (PEMFC) systems’ reliable operation under variable load conditions is a significant challenge because of voltage fluctuations, transient variations, and the high computational requirements of sophisticated control techniques like intelligent and model predictive controllers. Even while these state-of-the-art methods provide great precision, complexity and cost often limit their real-time applicability, underscoring the need for a simpler but efficient control solution. To achieve effective voltage regulation in PEMFC systems, this study suggests a DC–DC buck converter in conjunction with a comparator-based proportional–integral–derivative (PID) control technique. In order to provide stable operation under both constant and changing load …

Low Climate Benefit Of Nordic Coastal Marshes: Site Conditions Outweigh Grazing Effects And Shape Trade-Offs Between Carbon Storage And Its Stability, Carmen Leiva-Dueñas, T. Banta, Christoffer Boström, Franziska Eller, Johan Eklöf, Line Holm Andersen, Kai Jensen, Marianna Lanari, Ella Logemann, Pere Masque, Thomas Ostertag, Christoph Reisdorff, Anaïs Richard, Anu Vehmaa, Jukka Alm, Mikael Von Numers, Dorte Krause-Jensen

Research outputs 2022 to 2026

Coastal marshes, recognized as effective organic carbon (OC) sinks, have gained attention for their potential contribution to climate mitigation through protection and restoration. However, the climate mitigation potential of Nordic coastal marshes remains understudied, likely due to their heterogeneous and often non-tidal nature. To fill this gap, we examined soil OC storage and accumulation rates, and the effects of grazing, a common management practice, across eight Nordic coastal marsh areas spanning broad climate and environmental gradients. We also assessed soil methane emissions in selected areas. The Nordic marshes studied store a median of 7 kg OC m⁻² (interquartile range, …

Solvent-Dependent Proteome Profiling In Edible Mushrooms (Hypsizygus Marmoreus And Agaricus Bisporus), Tanvir Ahmed, O'Lone, Angéla Juhász, Utpal Bose, Kenneth U. Agbo, Netsanet Shiferaw Terefe, Michelle L. Colgrave

Research outputs 2022 to 2026

This study compared five solvents - urea, carbonate-bicarbonate, citrate, phosphate, and water - for their ability to extract proteins from beech (BM) (Hypsizygus marmoreus) and Swiss brown (SB) (Agaricus bisporus) mushrooms. Using mass spectrometry-based proteomics and bioinformatics, we found that urea produced the highest total protein identifications by data-dependent acquisition at 1% false discovery rate (FDR): BM: 1739, SB: 1907; and by data-independent acquisition: BM: 1969, SB: 2172 proteins, especially enriching cytosolic and ribosomal proteins. Carbonate-bicarbonate favoured the extraction of metabolic and translational proteins, while citrate targeted extracellular and membrane-associated proteins related to cell wall dynamics. Phosphate-enriched catalytically active proteins, …

The Rise And Fall Of The World's Greatest Marine Biodiversity Hotspot, Alexandre C. Siqueira, Kiessling, Nussaïbah Raja, David R. Bellwood

Research outputs 2022 to 2026

Habitat condition and area shape global species distributions, with shallow-water reefs hosting a disproportional share of marine biodiversity. Although reef area is a well-established predictor of marine species richness, its historical context is less well understood. Here, we show that the rise of tropical marine biodiversity is closely tied to reef expansion in space and time. During the Early/Mid Miocene (23 to 11.6 million years ago), Indo-Pacific reefs reached unprecedented size and thickness, surpassing any reef systems in the past 66 million years. These massive reefs, likely driven by unique environmental, biotic, and tectonic conditions, fostered the expanding diversity and …

Transitioning To Adolescent And Young Adult Or Adult Cancer Survivorship Care: A Systematic Review Of Contemporary Guidelines And Trials, Darren Haywood, Hammersley, Ursula Sansom-Daly, Jordana Mcloone, Evan Dauer, Helen Wilding, Nicolas H. Hart, Thomas Walwyn

Research outputs 2022 to 2026

Background: Health service transitions of child, adolescent, and young adult cancer survivors between paediatric and adult cancer care services are pervasively fragmented, resulting in poor coordination, reduced satisfaction, and adverse outcomes for cancer survivors and significant others (e.g., caregivers and family members). Numerous trials and clinical guidelines have been developed to support care transitions, but their convergence, divergence, and methodological quality remain unclear. To advance clinical practice and quality research about care transitions, a synthesis of trials and guidelines on child, adolescent, and young adult care transition across age-appropriate cancer services is required to inform future research, practice, guideline, and …

A High-Throughput Assay For Monitoring And Quantifying Amyloid-Β Accumulation And Clearance In Alzheimer's Disease Cell Models, Ajish Ariyath, Fraulein Denise Arigo, Anna Fyfe, W. M.A.D.Binosha Fernando, Ralph Martins, Prashant Bharadwaj

Research outputs 2022 to 2026

Amyloidogenic proteins, such as amyloid-β (Aβ), self-assemble into cross-β fibrils whose accumulation is central to Alzheimer's disease (AD). Measuring Aβ aggregation and clearance in living cells remains challenging using current cell-based assays, which are often low-throughput or not suited for real-time monitoring. This study aimed to (1) develop a robust, quantitative, and scalable fluorescence-based assay using Amytracker to monitor Aβ accumulation and clearance in an Aβ-producing neuronal cell model, and (2) validate its utility for mechanistic studies and therapeutic screening. We established a plate-based fluorescence assay using Amytracker in MC65 neuronal AD model expressing the Amyloid precursor protein C-terminal fragment …

Beyond The First Bout: Adaptations To Repeated Injuries Across Physiological And Pathological Conditions, Cory W. Baumann, Christopher P. Ingalls, Kazunori Nosaka, Jarrod A. Call

Research outputs 2022 to 2026

Skeletal muscle exhibits remarkable plasticity following injury, yet most research has focused on responses to a single bout of eccentric contractions. This review addresses adaptations to repeated eccentric contraction–induced injuries across physiological and pathological conditions, with emphasis on insights from preclinical rodent models. In healthy muscle, the repeated bout effect (RBE) reduces strength loss and accelerates recovery after subsequent bouts. However, these adaptations are highly condition dependent. Aging can attenuate the RBE, while dystrophic muscle remains vulnerable to repeated injury despite compensatory remodeling. Other factors, including but not limited to, chronic alcohol intake and malignant hyperthermia can influence these responses, …

Circulating Sphingomyelins Correlate With Plasma T-Tau In Cognitively Unimpaired Older Adults At Risk Of Developing Alzheimer's Disease, Tahmida Sharmin, James D. Doecke, Pratishtha Chatterjee, Steve Pedrini, Hamid R. Sohrabi, Nicholas J. Ashton, Henrik Zetterberg, Manohar L. Garg, Kaj Blennow, Ralph N. Martins

Research outputs 2022 to 2026

Alterations in plasma sphingomyelin (SM) levels have been reported in Alzheimer's disease (AD), pointing to disturbances in lipid metabolism that may contribute to disease pathogenesis. Neuronal damage in early AD triggers tau release into central and peripheral systems. Despite influence from peripheral contributions, alterations in plasma total-tau (T-tau) remain valuable in indicating AD-related neurodegeneration. Investigating relationships between SM metabolism and tau release during preclinical AD may uncover important biochemical processes and support advancing early non-invasive detection and treatment approaches. This cross-sectional study investigated cognitively unimpaired (CU) older adults from the KARVIAH cohort, grouped by cortical amyloid-β (Aβ) status through positron …

Diacylglycerol Kinase Eta As A Novel Target In Nras Mutant Melanoma, Haley P. Wilson, Casey D. Stefanski, Signe Caksa, Glenn L. Mersky, Scott D. Varney, Jelan I. Haj, Dan A. Erkes, Timothy J. Purwin, Vivian Chua, Andrew E. Aplin

Research outputs 2022 to 2026

NRAS mutations occur in 10%–30% of cutaneous melanomas and are associated with high tumor mutational burden. Mutant NRAS signaling drives aberrant cell growth and proliferation, in part, through activation of the RAF–MEK-ERK1/2 kinase pathway; however, targeted therapies to this pathway have limited effectiveness in patients with NRAS mutant melanoma. The role of other targetable signaling pathways in NRAS mutant melanoma is poorly characterized. Here, we demonstrated that one isoform of diacylglycerol kinase, diacylglycerol kinase eta (DGKη), a lipid signaling regulator, was highly expressed in NRAS mutant melanoma patient samples. Knockdown of DGKH in NRAS mutant melanoma cell lines resulted in …

Diversification For Stock Markets: Commodities Or Crypto, Mico Apostolov, Simone Domenico Scagnelli, Lorenzo Vasile

Research outputs 2022 to 2026

The question that an asset could serve as a good store of value has been brought up a number of times, especially due to major market shocks. Despite the long-held belief that gold serves as a safe haven, a growing body of contemporary literature perpetually assesses this notion. Whether cryptocurrencies, namely Bitcoin as the most well-known of them, as an asset, can serve as a safe haven or hedge gains traction in research. This study investigates the relationship of gold and Bitcoin to S&P 500 stock index and the possibility that these might serve as a safe haven in respect …

Engineered Uio-66-Nh2 Hybrid Nanocomposites For Antifouling Ultrafiltration Membranes With Dual Resistance To Microplastics And Protein Fouling, Mitra Golgoli, Mohadeseh Najafi, Javad Farahbakhsh, Masoumeh Zargar

Research outputs 2022 to 2026

The growing presence of microplastics (MPs) in water and their impact on ultrafiltration (UF) membranes during the early stages of wastewater treatment highlight the need for effective mitigation strategies. This study explores the innovative modification of UF membranes by incorporating various hybrid metal-organic frameworks (MOFs) nanoparticles, including UiO-66-NH2 hybrids with multi-walled carbon nanotubes (MWCNTs) (UiOM), chitosan (UiOC), and sulfobetaine zwitterions (UiOZ). These nanoparticles were synthesized and integrated into innovative UF membranes to compare their performance on MPs fouling effect in particular. The integration enhanced membrane hydrophilicity and altered surface roughness, creating a hydrophilic functional network that improved water permeability. Water …

Growing Older Across Time And Space: The Impact Of Various Forms Of Capital On Social Support Networks Among Older Vietnamese Migrants, Hien Thi Nguyen, Lukasz Krzyzowski, Loretta Baldassar

Research outputs 2022 to 2026

Much has been written about the important role of social support networks (SSNs) for the well-being of older adults, encompassing their social, emotional and practical needs. Less is known about what happens to the SSNs of older people when they migrate, and even fewer studies have examined the impact of different forms of capital on these networks. Drawing on ethnographic interviews and participant observation with 22 older Vietnamese migrants in Australia (2020–21), this paper explores the influence of different forms of social, cultural, economic and symbolic capital on their SSNs. Data analysis comprised egocentric social network analysis of the connections …

Neuromuscular Performance Changes In Response To The Australian Special Forces Selection Course, Angela Uphill, Kristina L. Kendall, Stuart Guppy, Michael Vacher, Simon Parker, Hannah Brown, Brendan Ashmore, Travis Zomer, G. Gregory Haff

Research outputs 2022 to 2026

Introduction: Strenuous military activities, such as Special Forces (SF) selection courses, are known to involve high physical loads in the presence of food and sleep deprivation, which can have detrimental impacts on physical performance. Understanding the magnitude of performance deficit and the time required for recovery associated with these events, is important for injury prevention and maintaining operational readiness. The purpose of this study was to investigate the changes in physical performance in response to the Australian SF Selection Course (SF-SC) and to monitor recovery throughout 8 weeks following the course. Materials and Methods: Ninety-three healthy male participants (age: 28 …