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A Novel Method For Solving The Time-Dependent Shortest Path Problem Under Bipolar Neutrosophic Fuzzy Arc Values, Vidhya K, Saraswathi A, Broumi Said

Neutrosophic Sets and Systems

The Shortest path problem is highly relevant in our daily lives, addressing uncertainties like traffic conditions and weather variations. To handle such uncertainties, we utilize Fuzzy Numbers. This paper focuses on Bipolar Neutrosophic Fuzzy Numbers, which have dual positive and negative aspects. They provide a robust framework for representing arc (node/edge) weights, signifying uncertain travel times between nodes. Importantly, these weights can change over time in bipolar neutrosophic fuzzy graphs. Our study introduces an extended Bellman-Ford Algorithm for identifying optimal paths and minimum times with time-dependent Bipolar Neutrosophic Fuzzy arc weights. We demonstrate its effectiveness through a step-by-step numerical example …

Neutrosophic Doubt Fuzzy Bi-Ideal Of Bs-Algebras, P. Ayesha Parveen, M. Himaya Jaleela Begum

Neutrosophic Sets and Systems

In this research paper, our aim is to introduce the new concept of neutrosophic doubt fuzzy bi-ideal of BS algebras as an extension of doubt fuzzy bi-ideal of BS-algebras and investigated its algebraic nature. Neutrosophic doubt fuzzy bi-ideal of BS-algebras is also applied in Cartesian product. Finally, we also provide the homomorphic behaviour of Neutrosophic doubt fuzzy bi-ideal of BS-algebras.

Neutrosophic Vision Of The Expected Opportunity Loss Criterion (Neol) Decision Making Under Risk, Maissam Jdid, Florentin Smarandache

Neutrosophic Sets and Systems

One of the major challenges facing decision-makers at the present time is obtaining complete information about the issue under study, due to the unstable conditions of the work environment that are beyond the control of decision-makers, which requires them to reach an optimal decision in light of these circumstances and fluctuations and to benefit from the data that is collected. Collected by specialists to determine the appropriate probability distribution corresponding to random cases of nature, here we are faced with the issue of making a decision in the event of risk because the probability distribution is a distribution linked to …

Production Planning With The Neutrosophic Fuzzy Multi-Objective Optimization Technique, Şule Bayazit Bedirhanoğlu, Mahmut Atlas

Neutrosophic Sets and Systems

Businesses want to realize their production at the desired time and quality. In addition, businesses aim to use their existing resources efficiently and increase their earnings. The realization of more than one purpose is achieved by multi-purpose planning of production. This study considered the multi-objective production planning of a company that manufactures spare parts for household appliances. The management of the company wants to minimize its cost, cycle time, defective rates, and material wastage while maximizing its profits in the process of producing all 121 different products. This study presents a solution for this multi-item multi-objective production problem using the …

Evaluation Of Sustainable Waste Valorization Using Treesoft Set With Neutrosophic Sets, Ali Alqazzaz, Karam M. Sallam

Neutrosophic Sets and Systems

This study proposed a neutrosophic set framework with TreeSoft Set for sustainable waste valorization selection. The neutrosophic set is used to overcome uncertainty and vague information in the evaluation process. The neutrosophic set has three membership degrees: truth, indeterminacy, and falsity. The multi criteria decision-making (MCDM) methodology deals with various criteria to evaluate waste valorization. The VIKOR method is an MCDM method used to rank the alternatives. The numerical example was created with 12 criteria and 10 alternatives. Three decision-makers and experts are invited to evaluate the requirements and options. We used the bipolar neutrosophic numbers to replace the opinions …

Modeling Influenced Criteria In Classifiers' Imbalanced Challenges Based On Trss Bolstered By The Vague Nature Of Neutrosophic Theory, Ibrahim El-Henawy, Shrouk El-Amir, Mona Mohamed, Florentin Smarandache

Neutrosophic Sets and Systems

Because of the advancements in technology, classification learning has become an essential activity in today's environment. Unfortunately, through the classification process, we noticed that the classifiers are unable to deal with the imbalanced data, which indicates there are many more instances (majority instances) in one class than in another. Identifying an appropriate classifier among the various candidates is a time-consuming and complex effort. Improper selection can hinder the classification model's ability to provide the right outcomes. Also, this operation requires preference among a set of alternatives by a set of criteria. Hence, multi-criteria decision making (MCDM) methodology is the appropriate …

New Fixed Point Results In Neutrosophic Metric Spaces, Umar Ishtiaq, Fahim Ud Din, Mureed Qasim, Lakhdar Ragoub, Khalil Javed

Neutrosophic Sets and Systems

In this manuscript, we give the generalization of banach’s, Kannan’s and Chatterjee’s fixed Point theorems in neutrosophic metric spaces by using new (TS-IF⍺) contractive mappings. Also, we establish common fixed point results in neutrosophic metric space by using Occasionally weakly compatible maps for integral type inequalities.

Neutrosophic Sets And Systems, Vol. 65,2024, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

Autoantibodies, Antigen-Autoantibody Complexes And Antigens Complement Ca125 For Early Detection Of Ovarian Cancer, Chae Young Han, Jacob S Bedia, Wei-Lei Yang, Sarah J Hawley, Lindsay Bergan, Marika Hopper, Joseph Celestino, Jing Guo, Terrie G Gornet, Antoninus Soosaipillai, Hailing Yang, Samantha D Doskocil, Anna E Lokshin, Beverly C Handy, Eleftherios P Diamandis, Richard G Moore, Karen H Lu, Zhen Lu, Karen S Anderson, Charles W Drescher, Steven J Skates, Robert C Bast

Faculty, Staff and Student Publications

BACKGROUND: Multiple antigens, autoantibodies (AAb), and antigen-autoantibody (Ag-AAb) complexes were compared for their ability to complement CA125 for early detection of ovarian cancer.

METHODS: Twenty six biomarkers were measured in a single panel of sera from women with early stage (I-II) ovarian cancers (n = 64), late stage (III-IV) ovarian cancers (186), benign pelvic masses (200) and from healthy controls (502), and then split randomly (50:50) into a training set to identify the most promising classifier and a validation set to compare its performance to CA125 alone.

RESULTS: Eight biomarkers detected ≥ 8% of early stage cases at 98% specificity. …

Amyopathic Dermatomyositis May Be On The Spectrum Of Autoinflammatory Disease: A Clinical Review, Saika Sharmeen, Lisa Christopher-Stine, Joann N Salvemini, Peter Gorevic, Richard Clark, Qingping Yao

Faculty, Staff and Student Publications

Systemic autoinflammatory diseases (SAIDs) are distinct from autoimmune diseases. The former primarily results from abnormal innate immune response and genetic testing is crucial for disease diagnosis. Similar cutaneous involvement is a main feature for both SAID and dermatomyositis (DM), so they can be confused with each other. A literature search of PubMed and MEDLINE was conducted for relevant articles. The similarities and differences between these two types of diseases were analyzed. We found phenotypic similarities between these two types of disorders. Accumulating data supports a major role of the innate immune system and a similar cytokine profile. Molecular testing using …

Safety And Tolerability Of Phenylbutyrate In Inclusion Body Myositis, Duaa Jabari, Andrew Heim, Ali Ciersdorff, Heather M. Wilkins, Abdulbaki Agbas, Edina Kosa, Suzanne Hunt, Mamatha Pasnoor, Mazen M. Dimachkie, Richard J. Barohn

Faculty and Staff Publications

Introduction

Phenylbutyrate (PBA) showed positive effect on the muscle cell model of Inclusion Body Myositis (IBM) by improving lysosomal activity, ameliorating consequences of impaired autophagy, and decreasing vacuolization. This provides rationale to study this medication in patients with IBM.

Objectives

To evaluate the safety and tolerability of phenylbutyrate in IBM, and monitor for any early signal of effectiveness.

Methods

Open-label study of 10 subjects with IBM who received treatment with PBA for 3 months after a 3-month run-in period. The PBA dose was 3 gm twice daily. The primary outcome measure was adverse event reporting. Secondary outcome measures included manual …

Oblique Anterior Column Realignment With A Mini-Open Posterior Column Osteotomy For Minimally Invasive Adult Spinal Deformity Correction: Illustrative Case, Zach Pennington, Nolan J. Brown, Seyedamirhossein Pishva, Hernán F.J. González, Martin H. Pham

Student Publications

BACKGROUND Adult spinal deformity (ASD) occurs from progressive anterior column collapse due to disc space desiccation, compression fractures, and autofusion across disc spaces. Anterior column realignment (ACR) is increasingly recognized as a powerful tool to address ASD by progressively lengthening the anterior column through the release of the anterior longitudinal ligament during lateral interbody approaches. Here, we describe the application of minimally invasive ACR through an oblique antepsoas corridor for deformity correction in a patient with adult degenerative scoliosis and significant sagittal imbalance.

OBSERVATIONS A 65-year-old female with a prior history of L4–5 transforaminal lumbar interbody fusion and morbid obesity …

A Cadaveric Study Of The Deep And Superficial Dorsal Veins For Penile Transplant, Sirai Ramirez, Nawsin Baset, Andrew Brevik, Nathaniel Ballek, Alyssa Kendell, Ryan Schiller, Anthony Olinger

Student Publications

Objective: It is crucial to know the lengths of the neurovasculature proximal to a penile allograft to allow for better viability of a penile transplant. We performed a cadaveric exploration focused on the deep and superficial dorsal veins as identified in a microsurgical dissection of the penis to help expand the anatomical knowledge for such a procedure.

Methods: We examined 18 cadavers and measured the (1) vertical distance from the pubic symphysis to the point at which the superficial dorsal vein is no longer on the erectile tissue; (2) point at which the superficial dorsal vein is no …

Play Time: Gender, Anti-Semitism And Temporality In Medieval Biblical Drama By Daisy Black (Review), Christopher B. Swift

Publications and Research

No abstract provided.

Desirability Of Outcome Ranking For Obstetrical Trials: Illustration And Application To The Arrive Trial, Grecio J Sandoval, William A Grobman, Scott R Evans, Madeline M Rice, Rebecca G Clifton, Suneet P Chauhan, Maged M Costantine, Kelly S Gibson, Monica Longo, Torri D Metz, Emily S Miller, Samuel Parry, Uma M Reddy, Dwight J Rouse, Hyagriv N Simhan, John M Thorp, Alan T N Tita, George R Saade

Faculty, Staff and Student Publications

BACKGROUND: In randomized trials, 1 primary outcome is typically chosen to evaluate the consequences of an intervention, whereas other important outcomes are relegated to secondary outcomes. This issue is amplified for many obstetrical trials in which an intervention may have consequences for both the pregnant person and the child. In contrast, desirability of outcome ranking, a paradigm shift for the design and analysis of clinical trials based on patient-centric evaluation, allows multiple outcomes-including from >1 individual-to be considered concurrently.

OBJECTIVE: This study aimed to describe desirability of outcome ranking methodology tailored to obstetrical trials and to apply the methodology to …

Image-Based Multiplex Immune Profiling Of Cancer Tissues: Translational Implications A Report Of The International Immuno-Oncology Biomarker Working Group On Breast Cancer, Chowdhury Arif Jahangir, David B Page, Glenn Broeckx, Claudia A Gonzalez, Caoimbhe Burke, Clodagh Murphy, Jorge S Reis-Filho, Amy Ly, Paul W Harms, Rajarsi R Gupta, Michael Vieth, Akira I Hida, Mohamed Kahila, Zuzana Kos, Paul J Van Diest, Sara Verbandt, Jeppe Thagaard, Reena Khiroya, Khalid Abduljabbar, Gabriela Acosta Haab, Balazs Acs, Sylvia Adams, Jonas S Almeida, Isabel Alvarado-Cabrero, Farid Azmoudeh-Ardalan, Sunil Badve, Nurkhairul Bariyah Baharun, Enrique R Bellolio, Vydehi Bheemaraju, Kim Rm Blenman, Luciana Botinelly Mendonça Fujimoto, Octavio Burgues, Alexandros Chardas, Maggie Chon U Cheang, Francesco Ciompi, Lee Ad Cooper, An Coosemans, Germán Corredor, Flavio Luis Dantas Portela, Frederik Deman, Sandra Demaria, Sarah N Dudgeon, Mahmoud Elghazawy, Claudio Fernandez-Martín, Susan Fineberg, Stephen B Fox, Jennifer M Giltnane, Sacha Gnjatic, Paula I Gonzalez-Ericsson, Anita Grigoriadis, Niels Halama, Matthew G Hanna, Aparna Harbhajanka, Steven N Hart, Johan Hartman, Stephen Hewitt, Hugo M Horlings, Zaheed Husain, Sheeba Irshad, Emiel Am Janssen, Tatsuki R Kataoka, Kosuke Kawaguchi, Andrey I Khramtsov, Umay Kiraz, Pawan Kirtani, Liudmila L Kodach, Konstanty Korski, Guray Akturk, Ely Scott, Anikó Kovács, Anne-Vibeke Laenkholm, Corinna Lang-Schwarz, Denis Larsimont, Jochen K Lennerz, Marvin Lerousseau, Xiaoxian Li, Anant Madabhushi, Sai K Maley, Vidya Manur Narasimhamurthy, Douglas K Marks, Elizabeth S Mcdonald, Ravi Mehrotra, Stefan Michiels, Durga Kharidehal, Fayyaz Ul Amir Afsar Minhas, Shachi Mittal, David A Moore, Shamim Mushtaq, Hussain Nighat, Thomas Papathomas, Frederique Penault-Llorca, Rashindrie D Perera, Christopher J Pinard, Juan Carlos Pinto-Cardenas, Giancarlo Pruneri, Lajos Pusztai, Nasir Mahmood Rajpoot, Bernardo Leon Rapoport, Tilman T Rau, Joana M Ribeiro, David Rimm, Anne Vincent-Salomon, Joel Saltz, Shahin Sayed, Evangelos Hytopoulos, Sarah Mahon, Kalliopi P Siziopikou, Christos Sotiriou, Albrecht Stenzinger, Maher A Sughayer, Daniel Sur, Fraser Symmans, Sunao Tanaka, Timothy Taxter, Sabine Tejpar, Jonas Teuwen, E Aubrey Thompson, Trine Tramm, William T Tran, Jeroen Van Der Laak, Gregory E Verghese, Giuseppe Viale, Noorul Wahab, Thomas Walter, Yannick Waumans, Hannah Y Wen, Wentao Yang, Yinyin Yuan, John Bartlett, Sibylle Loibl, Carsten Denkert, Peter Savas, Sherene Loi, Elisabeth Specht Stovgaard, Roberto Salgado, William M Gallagher, Arman Rahman

Faculty, Staff and Student Publications

Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged as potent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, thereby expanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing the phenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinically relevant biomarkers with high-throughput multiplex immunophenotyping of tumour …

The Risk And Burden Of Thromboembolic And Hemorrhagic Events In Patients With Malignant Gliomas Receiving Bevacizumab, Pushan Dasgupta, Alexander Ou, Heather Lin, Timothy Gregory, Kristin D Alfaro-Munoz, Ying Yuan, Vahid Afshar-Khargan, Carlos Kamiya-Matsuoka, Justin F Rousseau, Nazanin K Majd

Faculty, Staff and Student Publications

Purpose: Bevacizumab has evolved as an integral treatment option for patients with high-grade gliomas. Little is known about clinical risk factors that predispose patients with high-grade gliomas receiving bevacizumab to VTE or ICH. We sought to characterize the clinical risk factors associated with risk of either event.

Methods: In this multi-institutional retrospective study, we first evaluated patients with high-grade gliomas who were treated with bevacizumab at University of Texas MD Anderson Cancer Center from 2015-2021. We compared clinical and treatment-related factors among three cohorts: those who developed VTE, ICH, or neither. We further compared survival outcomes of these patients from …

A Phase I Study Of Docetaxel Plus Synthetic Lycopene In Metastatic Prostate Cancer Patients, Michael B Lilly, Chunli Wu, Yu Ke, Wen-Pin Chen, Adam C Soloff, Kent Armeson, Noriko N Yokoyama, Xiaotian Li, Liankun Song, Ying Yuan, Christine E Mclaren, Xiaolin Zi

Faculty, Staff and Student Publications

Purpose: Our preclinical studies showed that lycopene enhanced the anti-prostate cancer efficacy of docetaxel in animal models. A phase I trial (NCT0149519) was conducted to identify an optimum dose of synthetic lycopene in combination with docetaxel (and androgen blockade [androgen deprivation therapy, ADT]), and to evaluate its effect on the safety and pharmacokinetics of docetaxel in men with metastatic prostate cancer.

Methods: Subjects were treated with 21-day cycles of 75 mg/m2 docetaxel (and ADT), plus lycopene at 30, 90 or 150 mg/day. A Bayesian model averaging continual reassessment method was used to guide dose escalation. Pharmacokinetics of docetaxel …

Prenatal Vs Postnatal Diagnosis Of 22q112 Deletion Syndrome: Cardiac And Noncardiac Outcomes Through 1 Year Of Age, Lindsay R Freud, Stephanie Galloway, T Blaine Crowley, Julie Moldenhauer, Ann Swillen, Jeroen Breckpot, Antoni Borrell, Neeta L Vora, Bettina Cuneo, Hilary Hoffman, Lisa Gilbert, Beata Nowakowska, Maciej Geremek, Anna Kutkowska-Kaźmierczak, Joris R Vermeesch, Koen Devriendt, Tiffany Busa, Sabine Sigaudy, Trisha Vigneswaran, John M Simpson, Jeffrey Dungan, Nina Gotteiner, Karl-Philipp Gloning, Maria Cristina Digilio, Marta Unolt, Carolina Putotto, Bruno Marino, Gabriela Repetto, Magdalena Fadic, Sixto Garcia-Minaur, Ana Achón Buil, Mary Ann Thomas, Deborah Fruitman, Taylor Beecroft, Pui Wah Hui, Solveig Oskarsdottir, Rachael Bradshaw, Amanda Criebaum, Mary E Norton, Tiffany Lee, Miwa Geiger, Leslie Dunnington, Jacqueline Isaac, Louise Wilkins-Haug, Lindsey Hunter, Claudia Izzi, Marika Toscano, Tullio Ghi, Julie Mcglynn, Francesca Romana Grati, Beverly S Emanuel, Kimberly Gaiser, J William Gaynor, Elizabeth Goldmuntz, Daniel E Mcginn, Erica Schindewolf, Oanh Tran, Elaine H Zackai, Qi Yan, Anne S Bassett, Ronald Wapner, Donna M Mcdonald-Mcginn

Faculty, Staff and Student Publications

Background: The 22q11.2 deletion syndrome is the most common microdeletion syndrome and is frequently associated with congenital heart disease. Prenatal diagnosis of 22q11.2 deletion syndrome is increasingly offered. It is unknown whether there is a clinical benefit to prenatal detection as compared with postnatal diagnosis.

Objective: This study aimed to determine differences in perinatal and infant outcomes between patients with prenatal and postnatal diagnosis of 22q11.2 deletion syndrome.

Study design: This was a retrospective cohort study across multiple international centers (30 sites, 4 continents) from 2006 to 2019. Participants were fetuses, neonates, or infants with a genetic diagnosis of 22q11.2 …

The Influence Of Societal Nationalist Sentiment On Trade Flows, Douglas Dow, Ilya Cuypers

Research Collection Lee Kong Chian School Of Business

In recent years, the world has witnessed a backlash against globalization and a rise in populist and nationalist movements around the world. However, there appears to be little empirical research concerning how these movements, and especially nationalist sentiment, actually influence trade. Therefore, we explore how and when nationalist sentiment within a country influences trade. Our results indicate that the effect of nationalist sentiment on imports is mediated by lower participation in free trade agreements (FTAs) but not via tariffs. Furthermore, we are unable to confirm support for a direct effect of nationalist sentiment on imports, as predicted by the consumer …

Demand Pull Versus Resource Push Training Approaches To Entrepreneurship: A Field Experiment, Simone Santamaria, Niloofar Abolfathi, Ishtiag Pasha Mahmood

Research Collection Lee Kong Chian School Of Business

We compare the efficacy of two broad approaches to entrepreneurship training: a training prioritizing demand-side activities versus a training prioritizing resource-side activities. We do so by running a field experiment inside a 6-month entrepreneurship program involving 236 early-stage entrepreneurs. Inspired by our training, the first group invested more time interacting with potential customers and developing a deep understanding of customer needs and problems. The other group, in contrast, spent more time identifying and exploiting their core resources such as their network. Our results reveal that the training prioritizing demand-side activities is substantially more effective. At the end of the program, …

Reproducibility In Management Science, MiloˇS Fišar, Ben Greiner, Christoph Huber, Elena Katok, Ali I. Ozkes, Hannah H. Chang

Research Collection Lee Kong Chian School Of Business

With the help of more than 700 reviewers, we assess the reproducibility of nearly 500 articles published in the journal Management Science before and after the introduction of a new Data and Code Disclosure policy in 2019. When considering only articles for which data accessibility and hardware and software requirements were not an obstacle for reviewers, the results of more than 95% of articles under the new disclosure policy could be fully or largely computationally reproduced. However, for 29% of articles, at least part of the data set was not accessible to the reviewer. Considering all articles in our sample …

Math Word Problem Generation Via Disentangled Memory Retrieval, Wei Qin, Xiaowei Wang, Zhenzhen Hu, Lei Wang, Yunshi Lan, Richang Hong

Research Collection Lee Kong Chian School Of Business

The task of math word problem (MWP) generation, which generates an MWP given an equation and relevant topic words, has increasingly attracted researchers’ attention. In this work, we introduce a simple memory retrieval module to search related training MWPs, which are used to augment the generation. To retrieve more relevant training data, we also propose a disentangled memory retrieval module based on the simple memory retrieval module. To this end, we first disentangle the training MWPs into logical description and scenario description and then record them in respective memory modules. Later, we use the given equation and topic words as …

A Review Of Gerd Lüdemann’S Methodology In “The Resurrection Of Christ: A Historical Inquiry”, Kelvin Ruel G. Novabos

Loyola Papers

This article critically evaluates Gerd Lüdemann’s historical methodology in his study of the resurrection of Jesus. Situating Lüdemann’s work within the broader context of the quests for the historical Jesus, this paper identifies both its methodological strengths and its limitations, particularly its reliance on a strictly historical-critical approach. It argues that a more integrative methodology—drawing from developments in the third quest—would yield a more balanced and credible interpretation of the resurrection accounts.

A Job Satisfaction Evaluation Of Nursing In The United States And Greece Utilizing The American Nurses Association's Scope And Standards Of Practice, Audrey Narhi

Honors Projects

Nursing is a multifaceted profession that is constantly evolving with the health needs of the populations it serves. Professional organizations within the field utilize evidence-based practice to provide guidelines of what best-practice nursing is. This study aims to evaluate if the American Nurse's Association (ANA), a professional nursing organization in the United States, supports the realities of nursing in a rural US hospital. An international perspective is also considered by evaluating the same principles to a urban hospital in Athens, Greece. Categories that align with ANA Scope and Standards, including workplace environment, career development, supervisor relationships, and personal work practice, …

The Role Of Artificial Intelligence For Providing Scientific Content For Laboratory Medicine, Alan H B Wu, Allan S Jaffe, William Franklin Peacock, Pete Kavsak, Dina Greene, Robert H Christenson

Faculty, Staff and Students Publications

Background: Artificial intelligence (AI) promises to become an important tool in the practice of laboratory medicine. AI programs are available online that can provide concise medical and laboratory information within seconds after a question is submitted.

Methods: We posed the following contemporary and relevant question for clinical chemists using an AI program: "Should labs eliminate CK-MB testing?" The results of this inquiry were critically reviewed by a cardiologist, emergency department physician, and clinical laboratorians for accuracy and appropriateness.

Results: An AI report answering this question was generated within 15 s. The experts felt that the information was inaccurate with the …

Invited Commentary On Andersen S, Et Al Developmental Windows Of Environmental Vulnerability For Inflammatory Bowel Disease, David A Simon, Richard Kellermayer

Faculty, Staff and Students Publications

No abstract provided.

Psychosocial Moderators Of Polygenic Risk Scores Of Inflammatory Biomarkers In Relation To Grimage, Amanda J F Tamman, Dora Koller, Sheila Nagamatsu, Brenda Cabrera-Mendoza, Chadi Abdallah, John H Krystal, Joel Gelernter, Janitza L Montalvo-Ortiz, Renato Polimanti, Robert H Pietrzak

Faculty, Staff and Students Publications

GrimAge acceleration has previously predicted age-related morbidities and mortality. In the current study, we sought to examine how GrimAge is associated with genetic predisposition for systemic inflammation and whether psychosocial factors moderate this association. Military veterans from the National Health and Resilience in Veterans study, which surveyed a nationally representative sample of European American male veterans, provided saliva samples for genotyping (N = 1135). We derived polygenic risk scores (PRS) from the UK Biobank as markers of genetic predisposition to inflammation. Results revealed that PRS for three inflammatory PRS markers—HDL (lower), apolipoprotein B (lower), and gamma-glutamyl transferase (higher)—were associated …

The Pug Flap: Conjoined Profunda Artery Perforator And Upper Gracilis Flap For Breast Reconstruction, Isra Abdulwadood, Lacey R Pflibsen, Nicholas R Jarvis, Sebastian Winocour, Alanna M Rebecca, William J Casey, Edward M Reece

Faculty, Staff and Students Publications

Abdominal-based free flaps are the mainstay of autologous breast reconstruction; however, the region may not be ideal for patients with inadequate soft tissue or history of abdominal surgery. This case describes the use of a novel conjoined flap based on the profunda artery perforator and upper gracilis pedicles, named the perforator and upper gracilis (PUG) flap. This flap design aims to maximize medial thigh flap volume while ensuring robust tissue perforation. Here, we present our experience with the PUG flap in a breast cancer patient undergoing autologous reconstruction. The patient was a 41-year-old woman seeking nipple-sparing mastectomy and immediate autologous …

Environmental Justice: A Missing Core Tenet Of Global Health, Redeat Workneh, Merhawit Abadi, Krystle Perez, Sharla Rent, Elliott Mark Weiss, Stephanie Kukora, Olivia Brandon, Gal Barbut, Sahar Rahiem, Shaphil Wallie, Joseph Mhango, Benjamin C Shayo, Friday Saidi, Gesit Metaferia, Mahlet Abayneh, Gregory C Valentine

Faculty, Staff and Students Publications

No abstract provided.