Digital Commons Network^™

Rapid Measurement Of Hemoglobin-Oxygen Dissociation By Leveraging Bohr Effect And Soret Band Bathochromic Shift, Zoe Sekyonda, Ran An, Utku Goreke, Yuncheng Man, Karamoja Monchamp, Allison Bode, Qiaochu Zhang, Ozan Akkus, Umut A. Gurkan

Faculty Scholarship

Oxygen (O2) binds to hemoglobin (Hb) in the lungs and is then released (dissociated) in the tissues. The Bohr effect is a physiological mechanism that governs the affinity of Hb for O2 based on pH, where a lower pH results in a lower Hb-O2 affinity and higher Hb-O2 dissociation. Hb-O2 affinity and dissociation are crucial for maintaining aerobic metabolism in cells and tissues. Despite its vital role in human physiology, Hb-O2 dissociation measurement is underutilized in basic research and in clinical laboratories, primarily due to the technical complexity and limited throughput of existing methods. We present a rapid Hb-O2 dissociation …

Satellite Cluster Flight Using Guidance Trajectory And Model Predictive Control, Tyson K. Smith, John Akagi, Greg Droge

Space Dynamics Laboratory Publications

This paper presents a model predictive control based framework that is used in conjunction with a polytope boundary constraint and the Hill- Clohessy-wiltshire equations to maintain a desired formation of a cluster of spacecraft while also allowing freedom to maneuver within the allowable bounds. A fuel optimal guidance trajectory is generated and the model predictive control framework controls to this desired trajectory. The operational polytope boundaries enable the predictive framework of the model predictive control to be used to make small maneuvers to correct perturbations from its desired trajectory. The boundaries are designed such that no two agents have overlapping …

Experiences Of Undergraduate Computer Science Students Living With Mental Health Conditions, J. Ji, Christian Murphy, B. Blaser, J. Akullian

Computer Science Faculty Works

Along with the growing number of students with disabilities in higher education comes an opportunity to explore the difficulties they experience, especially in the post-pandemic era, as well as how to better support them, thus making post-secondary education more inclusive. A considerable amount of research has been done in providing accommodation for students with physical disabilities, but other hindrances to accessibility such as mental health conditions are prone to be overlooked, perhaps in part due to the stigmatization and subjective invisibility of this topic, specifically in rigorous, competitive fields such as Computer Science (CS). In order to bridge this gap, …

Daily Injection Of The Β2 Adrenergic Agonist Clenbuterol Improved Muscle Glucose Metabolism, Glucose-Stimulated Insulin Secretion, And Hyperlipidemia In Juvenile Lambs Following Heat-Stress-Induced Intrauterine Growth Restriction, Rachel L. Gibbs, James Wilson, Rebecca M. Swanson, Joslyn K. Beard, Zena M. Hicks, Haley Beer, Eileen Marks-Nelson, Ty B. Schmidt, Jessica Lynn Petersen, Dustin T. Yates

Department of Animal Science: Faculty Publications

Stress-induced fetal programming diminishes β2 adrenergic tone, which coincides with intrauterine growth restriction (IUGR) and lifelong metabolic dysfunction. We determined if stimulating β2 adrenergic activity in IUGR-born lambs would improve metabolic outcomes. IUGR lambs that received daily injections of saline or the β2 agonist clenbuterol from birth to 60 days were compared with controls from pair-fed thermoneutral pregnancies. As juveniles, IUGR lambs exhibited systemic inflammation and robust metabolic dysfunction, including greater (p < 0.05) circulating TNF, IL-6, and non-esterified fatty acids, increased (p < 0.05) intramuscular glycogen, reduced (p < 0.05) circulating IGF-1, hindlimb blood flow, glucose-stimulated insulin secretion, and muscle glucose oxidation. Daily clenbuterol fully recovered (p < 0.05) circulating TNF, IL-6, and nonesterified fatty acids, hindlimb blood flow, muscle glucose oxidation, and intramuscular glycogen. Glucose-stimulated insulin secretion was partially recovered (p < 0.05) in clenbuterol-treated IUGR lambs, but circulating IGF-1 was not improved. Circulating triglycerides and HDL cholesterol were elevated (p < 0.05) in clenbuterol-treated IUGR lambs, despite being normal in untreated IUGR lambs. We conclude that deficient β2 adrenergic regulation is a primary mechanism for several components of metabolic dysfunction in IUGR-born offspring and thus represents a potential therapeutic target for improving metabolic outcomes. Moreover, benefits from the β2 agonist were likely complemented by its suppression of IUGR-associated inflammation.

Send Nudes?: Teens’ Perspectives Of Education Around Sexting, An Argument For A Balanced Approach, Giselle Natassia Woodley, Lelia Green, Carmen Jacques

Research outputs 2022 to 2026

This paper explores teens’ perceptions of Relationships and Sexuality Education (RSE) around sexting (the exchange of sexually explicit imagery). Adopting a ‘sex-positive’ balanced approach to adolescents’ digital expressions of sexuality may be a more beneficial response than censure since fear-based narratives fail to recognise sexting as part of an array of sexual behaviours enacted by teens. Prohibition, rather than educating for safe sexting practices, fails to protect young people. This qualitative study uses thematic analysis of interviews with teens, and social constructionism, to interpret their perspectives thereby contributing teens’ perspectives to debates around adolescent sexting and RSE.

Strategy As Problem-Solving, Andrew Carr

The US Army War College Quarterly: Parameters

This article proposes a new definition of strategy as problem-solving that challenges the focus on goals and assumptions of order within many post–Cold War approaches to strategy. It argues that the military needs strategy to diagnose the complex problems of the twenty-first century before they can be solved. Inspired by practitioners such as Andrew Marshall and George F. Kennan, this new definition clarifies what strategists do and offers a logic for distinguishing the use of the term strategy. Practitioners will also find problem-solving tools and pedagogies they can adopt today.

Centrifugal Forces Impacting Urbanization In The Eastern Mediterranean During Roman And Early Islamic Times, Øystein S. Labianca

Faculty Publications

My goal with this essay is to make the existence of a distinctive Levantine cultural paradigm a lens through which to examine long-term patterns of urbanization and cultural change in the Eastern Mediterranean—focusing especially on present-day Israel, Jordan and the Palestinian territories. Inspired by the agenda and approach of global history, the essay is an attempt to highlight a number of salient features of societal formation processes in this region that set them apart from such processes in the heartlands of ancient Egypt and Mesopotamia. The paradigm holds that societal formation dynamics in the Levant have been dominated more by …

Engl110 Course Syllabus (Composition), James Andrew Grammer

Open Educational Resources

Syllabus for Freshman Composition Course/Intro to Writing.

Liberty And Justice For Some: Comparing Dwi Convictions By Ethnicity, Gretel Busse, Daniel Wilkerson

FHSS Mentored Research Conference

This study observes potential disadvantages faced by minorities in the criminal justice system. Using data from DWI cases, we compare outcomes for Hispanic and white criminal defendants. Controlling for BrAC and criminal history, we find that Hispanics are more likely than whites to be convicted and incarcerated, and less likely to use a private attorney.

Knowledge, Attitudes, And Beliefs Toward Third Hand Smoke, Gisele Tah

Walden Dissertations and Doctoral Studies

Third hand smoke (THS) is gaining significant interest in the environmental and public health fields as a new but dangerous phenomenon. THS is identified as a form of passive smoke consisting of residual nicotine and chemicals that settle on surfaces. THS is reported to be genotoxic in human cells, yet the public has limited or no knowledge of this new concept. The purpose of this qualitative, interpretive, descriptive study was to discover and describe the level of knowledge, attitudes, practices, and beliefs regarding THS among individuals in an eastern U.S. state. Social cognitive theory provided the theoretical framework for this …

Understanding Adherence To Prescribed Medical Regimen To Treat Hypertension Among African American Males, Yolanda Lucian George

Walden Dissertations and Doctoral Studies

Hypertension is referred to as the silent killer and has been for decades. African Americans have been affected disproportionately compared to Whites, leading to a significant medical and financial burden. The literature has demonstrated that even though African Americans have a similar or better awareness of hypertension, they are more likely to have poorer treatment outcomes and have their hypertension less controlled. In this study, the health belief model and the ecological social model were used as the guiding framework to understand this phenomenon. In this qualitative study, semistructured interviews were used to explore and understand the perception of adherence …

A Phenomenological Thermodynamic Energy Density Function For Ferroelectric Wurtzite Al1−Xscxn Single Crystals, Yijia Gu, Andrew C. Meng, Aiden Ross, Long Qing Chen

Materials Science and Engineering Faculty Research & Creative Works

A Landau-Devonshire thermodynamic energy density function for ferroelectric wurtzite aluminum scandium nitride (Al1−xScxN) solid solution is developed. It is parametrized using available experimental and theoretical data, enabling the accurate reproduction of composition-dependent ferroelectric properties, such as spontaneous polarization, dielectric permittivity, and piezoelectric constants, for both bulk and thin films. The maximum concentration of Sc for the wurtzite structure to remain ferroelectric is found to be 61 at. %. A detailed analysis of Al1−xScxN thin films reveals that the ferroelectric phase transition and properties are insensitive to substrate strain. This study lays the foundation for quantitative modeling of novel ferroelectric wurtzite …

Metatranscriptomic Insights Into The Interaction Between Microcystis Blooms And Hydrogen Peroxide, Taylor L. Hancock

USF Tampa Graduate Theses and Dissertations

For this dissertation I studied the interactions of hydrogen peroxide and cyanobacterial harmful algal blooms (cHABs) dominated by Microcystis in the Caloosahatchee River, FL. Specifically, I examined how taxonomic and functional succession relates to both natural hydrogen peroxide dynamics and hydrogen peroxide added to the environment as a cHAB treatment. Chapter 2 investigated how taxonomic succession and gene expression patterns relate to blooms and associated elevated hydrogen peroxide concentrations. The results showed that gene expressions related to cyanobacterial growth were positively correlated with hydrogen peroxide. The genes identified included enzymes capable of hydrogen peroxide generation which were expressed by blooming …

Early Estimate Of Nirsevimab Effectiveness For Prevention Of Respiratory Syncytial Virus-Associated Hospitalization Among Infants Entering Their First Respiratory Syncytial Virus Season - New Vaccine Surveillance Network, October 2023-February 2024., Heidi L. Moline, Ayzsa Tannis, Ariana P. Toepfer, John V. Williams, Julie A. Boom, Janet A. Englund, Natasha B. Halasa, Mary Allen Staat, Geoffrey A. Weinberg, Rangaraj Selvarangan, Marian G. Michaels, Leila C. Sahni, Eileen J. Klein, Laura S. Stewart, Elizabeth P. Schlaudecker, Peter G. Szilagyi, Jennifer E. Schuster, Leah Goldstein, Samar Musa, Pedro A. Piedra, Danielle M. Zerr, Kristina A. Betters, Chelsea Rohlfs, Christina Albertin, Dithi Banerjee, Erin R. Mckeever, Casey Kalman, Benjamin R. Clopper, New Vaccine Surveillance Network Product Effectiveness Collaborators, Meredith L. Mcmorrow, Fatimah S. Dawood

Manuscripts, Articles, Book Chapters and Other Papers

Respiratory syncytial virus (RSV) is the leading cause of hospitalization among infants in the United States. In August 2023, CDC's Advisory Committee on Immunization Practices recommended nirsevimab, a long-acting monoclonal antibody, for infants agedtrials, nirsevimab efficacy against RSV-associated lower respiratory tract infection with hospitalization was 81% (95% CI = 62%-90%) through 150 days after receipt; post-introduction effectiveness has not been assessed in the United States. In this analysis, the New Vaccine Surveillance Network evaluated nirsevimab effectiveness against RSV-associated hospitalization among infants in their first RSV season during October 1, 2023-February 29, 2024. Among 699 infants hospitalized with acute respiratory illness, …

Perceived Challenges To Tribally Led Shellfish Toxin Testing In Southeast Alaska: Findings From Key Informant Interviews, Hugh B. Roland, Jacob Kohlhoff, Kari Lanphier, Sneha Hoysala, Esther G. Kennedy, John R. Harley, Christopher Whitehead, Matthew O. Gribble

Faculty, Staff, and Students

Shellfish harvesting is central to coastal Alaska Native ways of life, and tribes in Southeast Alaska are committed to preserving sustainable and safe access to subsistence foods. However, consumption of non-commercially harvested shellfish puts Alaska Native communities at elevated risk of exposure to shellfish toxins. To address a lack of state or federal toxin testing for subsistence and recreational harvesting, tribes across Southeast Alaska have formed their own toxin testing and ocean monitoring program. In this study, we interviewed environmental managers responsible for tribes' testing and others with shellfish toxin expertise to report on perceptions of barriers to tribally led …

Induction Of Neuroinflammation And Brain Oxidative Stress By Brain-Derived Extracellular Vesicles From Hypertensive Rats, Xinqian Chen, Xin Yan, Leah Gingerich, Qing Hui Chen, Lanrong Bi, Zhiying Shan

Michigan Tech Publications

Neuroinflammation and brain oxidative stress are recognized as significant contributors to hypertension including salt sensitive hypertension. Extracellular vesicles (EVs) play an essential role in intercellular communication in various situations, including physiological and pathological ones. Based on this evidence, we hypothesized that EVs derived from the brains of hypertensive rats with salt sensitivity could trigger neuroinflammation and oxidative stress during hypertension development. To test this hypothesis, we compared the impact of EVs isolated from the brains of hypertensive Dahl Salt-Sensitive rats (DSS) and normotensive Sprague Dawley (SD) rats on inflammatory factors and mitochondrial reactive oxygen species (mtROS) production in primary neuronal …

Variants In Zfx Are Associated With An X-Linked Neurodevelopmental Disorder With Recurrent Facial Gestalt\, James L Shepherdson, Katie Hutchison, Dilan Wellalage Don, George Mcgillivray, Tae-Ik Choi, Carolyn A Allan, David J Amor, Siddharth Banka, Donald G Basel, Laura D Buch, Deanna Alexis Carere, Renée Carroll, Jill Clayton-Smith, Ali Crawford, Morten Dunø, Laurence Faivre, Christopher P Gilfillan, Nina B Gold, Karen W Gripp, Emma Hobson, Alexander M Holtz, A Micheil Innes, Bertrand Isidor, Adam Jackson, Panagiotis Katsonis, Leila Amel Riazat Kesh, Genomics England Research Consortium;, Sébastien Küry, François Lecoquierre, Paul Lockhart, Julien Maraval, Naomichi Matsumoto, Julie Mccarrier, Josephine Mccarthy, Noriko Miyake, Lip Hen Moey, Andrea H Németh, Elsebet Østergaard, Rushina Patel, Kate Pope, Jennifer E Posey, Rhonda E Schnur, Marie Shaw, Elliot Stolerman, Julie P Taylor, Erin Wadman, Emma Wakeling, Susan M White, Lawrence C Wong, James R Lupski, Olivier Lichtarge, Mark A Corbett, Jozef Gecz, Charles M Nicolet, Peggy J Farnham, Cheol-Hee Kim, Marwan Shinawi

Duncan NRI Faculty and Staff Publications

Pathogenic variants in multiple genes on the X chromosome have been implicated in syndromic and non-syndromic intellectual disability disorders. ZFX on Xp22.11 encodes a transcription factor that has been linked to diverse processes including oncogenesis and development, but germline variants have not been characterized in association with disease. Here, we present clinical and molecular characterization of 18 individuals with germline ZFX variants. Exome or genome sequencing revealed 11 variants in 18 subjects (14 males and 4 females) from 16 unrelated families. Four missense variants were identified in 11 subjects, with seven truncation variants in the remaining individuals. Clinical findings included …

Who Do You Think Is The Greatest-Ever Economist?, Mark Skousen

Business Faculty Articles and Research

"Deciding who is the Greatest of All Time (GOAT) is a popular debate in sports. Is it Michael Jordan in basketball? Lionel Messi in fútbol? Muhammed Ali in boxing? Babe Ruth in baseball? (In case you are wondering, the answer is 'yes' in each category.)

Tyler Cowen, professor at George Mason University and co-publisher of the popular Marginal Revolution website, has come up with one of the most clever, entertaining ways to write a history of economic thought by selecting his favorite GOAT in economics."

Computational Design Of An Electro-Organocatalyst For Conversion Of Co2 Into Formaldehyde, Foroogh Khezeli, Craig Plaisance

Faculty Publications

Density functional theory calculations employing a hybrid implicit/explicit solvation method were used to explore a new strategy for electrochemical conversion of CO2 using an electro-organocatalyst. A particular structural motif is identified that consists of an electron-rich vicinal enediamine (>N-C═C-N<) backbone, which is capable of activating CO2 by the formation of a C-C bond while subsequently facilitating the transfer of electrons from a chemically inert cathode to ultimately produce formaldehyde. Unlike transition metal-based electrocatalysts, the electro-organocatalyst is not constrained by scaling relations between the formation energies of activated CO2 and adsorbed CO, nor is it expected to be active for the competing hydrogen evolution reaction. The rate-limiting steps are found to occur during two proton-coupled electron transfer (PCET) sequences and are associated with the transfer of a proton from a proton transfer mediator to a carbon atom on the electro-organocatalyst. The difficulty of this step in the second PCET sequence necessitates an electrode potential of −0.85 V vs RHE to achieve the maximum turnover frequency. In addition, it is postulated that the electro-organocatalyst should also be capable of forming long-chain aldehydes by successively carrying out reductive aldol condensation to grow the alkyl chain one carbon at a time.

Virtual Leadership The Challenges And Strategies To Overcome Them, Amberlee Marie Smock

M.S. in Leadership

The purpose of this paper is to delve into the challenges faced by virtual leaders and provide recommendations for overcoming those challenges in order to enhance team performance and engagement in a remote work setting. I selected this research because I started a new job at the height of covid-19 and I was sent home to do a job I had no idea how to do. My research aims to contribute to the development of practical guidelines for virtual leaders and organizations. The challenges include communication and collaboration, trust, rapport and information sharing, managing conflicts, a sense of belonging and …

Parameters Spring 2024, Usawc Press

The US Army War College Quarterly: Parameters

No abstract provided.

The Cowl - V. 88 N. 5 - March 7, 2024

The Cowl

The Cowl - student newspaper of Providence College. Vol. 88 No. 5 - March 7, 2024. 16 pages.

Assessing Forage Research And Education Needs Of Organic Dairy Farms In The United States, Eric Hatungimana, Heather M. Darby, Kathy J. Soder, Sara E. Ziegler, Andre F. Brito, Lisa Kissing Kucek, Heathcliffe Riday, E Charles Brummer

Faculty Publications

The viability of organic dairy operations in the United States (US) relies on forage production. The objectives of this study were to (1) assess producer and farm information regarding current forage production practices and producer knowledge gaps and (2) identify forage research and educational needs of organic dairy producers across the US. A survey was distributed to 643 organic dairy producers across the US, with 165 respondents (26% response rate). A focus group consisting of extension professionals, university researchers and staff, consultants, dairy industry representatives and organic dairy producers was also consulted for forage research needs. Results showed that approximately …

The Colby Echo (2024-03-07), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly during the academic year, 1898-present.

Ukraine: The Case For Urgency, Rebecca W. Jensen, Anthony L. Tingle

The US Army War College Quarterly: Parameters

If the United States and its allies seek to deny Vladimir Putin an objective victory in the Russia-Ukraine War, they must commit to providing sufficient aid to the Ukrainian army soon because the window of opportunity to provide sufficient resources is narrow—and closing. This article argues that the West must articulate a reasonable strategy for Ukrainian victory now, as a failure in Ukraine will weaken relationships between the United States and Western European states and their global partners while emboldening state and non-state actors to threaten the rules-based international order.

Toward A Strategic Art For Sanctions, David J. Katz

The US Army War College Quarterly: Parameters

New strategic art is required to maneuver political economies to meet the demands of future engagements and campaigns. Current discussions of the projection of political-economic power are typically abstract, high-level, and policy-focused or present singular tactical actions as strategic actions, creating a gap for campaign practitioners. This article addresses the gap by drawing on Joint Planning, Joint Publication 5-0, and Joint Campaigns and Operations, Joint Publication 3-0, to further develop the concept and methodologies first introduced in the author’s earlier article “Multidimensionality: Rethinking Power Projection for the 21st Century.”

International Law, Self-Defense, And The Israel-Hamas Conflict, Eric A. Heinze

The US Army War College Quarterly: Parameters

This article examines the international law of self-defense as it applies to the ongoing Israel-Hamas conflict to determine whether the October 2023 attacks by Hamas against Israel can be interpreted under Article 51 of the UN Charter as an “armed attack” that gives Israel the right to use military force in self-defense against non-state actors. It situates the conflict within ongoing legal and political debates, shows how this conflict fits into a changing global reality where the most dangerous security threats do not exclusively emanate from other states and concludes that Israel’s resort to force in the current conflict appears …

Us-Taiwan Relations And The Future Of The Liberal Order, Christina Lai

The US Army War College Quarterly: Parameters

Strengthening ties with Taiwan is the best chance the United States has to preserve the liberal international order in Asia and improve its security relative to China. This study offers a normative perspective on how Taiwan can contribute to US-led international institutions and the Asian regional order and reduce conflict risk. It concludes with recommendations for the United States and its partners to integrate Taiwan into multilateral institutions in Asia.

Rethinking The Relevance Of Self-Deterrence, Jeffrey H. Michaels

The US Army War College Quarterly: Parameters

Self-deterrence is critically understudied in deterrence theory. Similarly, deterrence practitioners prefer to focus on adversaries’ threats rather than seeking to account for the full scope of fears influencing the decision calculus of policymakers. Through historical case studies, this article identifies where self-deterrence has occurred, highlights the benefits of incorporating the concept in future strategic planning and intelligence assessments, and recommends that policymakers, strategists, and analysts acknowledge self-deterrence as an important factor when preparing for future wars.

The Politics Of Restraint In The Middle East, Andrew Payne

The US Army War College Quarterly: Parameters

Domestic constraints make it difficult for the United States to pursue a coherent program of restraint in the Middle East. As events in Gaza revive debates about the appropriate size and scope of the military footprint in the region, this article shows the importance of grounding any revised posture on a firm domestic foundation. Going beyond accounts that blame the obstructionism of a foreign policy establishment, it explores barriers to strategic adjustment and supports its claims through a case study of the Obama administration’s record, drawn from relevant literature, data on the distribution of military capabilities, and interviews with senior …