Digital Commons Network^™

Endovascular Thrombectomy Versus Intravenous Thrombolysis Of Posterior Cerebral Artery Occlusion Stroke, Silja Räty, Thanh N Nguyen, Simon Nagel, Davide Strambo, Patrik Michel, Christian Herweh, Muhammad M Qureshi, Mohamad Abdalkader, Pekka Virtanen, Marta Olive-Gadea, Marc Ribo, Marios Psychogios, Anh Nguyen, Joji B Kuramatsu, David Haupenthal, Martin Köhrmann, Cornelius Deuschl, Jordi Kühne Escolà, Jelle Demeestere, Robin Lemmens, Lieselotte Vandewalle, Shadi Yaghi, Liqi Shu, Volker Puetz, Daniel P O Kaiser, Johannes Kaesmacher, Adnan Mujanovic, Dominique Cornelius Marterstoc, Tobias Engelhorn, Anne Berberich, Piers Klein, Diogo C Haussen, Mahmoud H Mohammaden, Hend Abdelhamid, Isabel Fragata, Bruno Cunha, Michele Romoli, Wei Hu, Jianlon Song, Johanna T Fifi, Stavros Matsoukas, Sunil A Sheth, Sergio A Salazar-Marioni, João Pedro Marto, João Nuno Ramos, Milena Miszczuk, Christoph Riegler, Sven Poli, Khouloud Poli, Ashutosh P Jadhav, Shashvat Desai, Volker Maus, Maximilian Kaeder, Adnan H Siddiqui, Andre Monteiro, Tatu Kokkonen, Francesco Diana, Hesham E Masoud, Neil Suryadareva, Maxim Mokin, Shail Thanki, Pauli Ylikotila, Kemal Alpay, James E Siegler, Italo Linfante, Guilherme Dabus, Dileep Yavaghal, Vasu Saini, Christian H Nolte, Eberhart Siebert, Markus A Möhlenbruch, Peter A Ringleb, Raul G Nogueira, Uta Hanning, Lukas Meyer, Urs Fischer, Daniel Strbian

Faculty, Staff and Student Publications

Background and purpose: Posterior cerebral artery occlusion (PCAo) can cause long-term disability, yet randomized controlled trials to guide optimal reperfusion strategy are lacking. We compared the outcomes of PCAo patients treated with endovascular thrombectomy (EVT) with or without intravenous thrombolysis (IVT) to patients treated with IVT alone.

Methods: From the multicenter retrospective Posterior cerebraL ArTery Occlusion (PLATO) registry, we included patients with isolated PCAo treated with reperfusion therapy within 24 hours of onset between January 2015 and August 2022. The primary outcome was the distribution of the modified Rankin Scale (mRS) at 3 months. Other outcomes comprised 3-month excellent (mRS …

Obstacles To Optimal Antenatal Corticosteroid Administration To Eligible Patients, Kara M Rood, Lynda G Ugwu, William A Grobman, Jennifer L Bailit, Ronald J Wapner, Michael W Varner, John M Thorp, Steve N Caritis, Alan T N Tita, George R Saade, Dwight J Rouse, Sean C Blackwell, Jorge E Tolosa

Faculty, Staff and Student Publications

Background

Administration of antenatal corticosteroids (ANCS) is recommended for individuals expected to deliver between 24 and 34 weeks of gestation. Properly timed administration of ANCS achieves maximal benefit. However, more than 50% of individuals receive ANCS outside the recommended window.

Objective

To examine maternal and hospital factors associated with suboptimal receipt of ANCS among individuals who deliver between 24–34 weeks gestation.

Study Design

Secondary analysis of the Assessment of Perinatal Excellence (APEX), an observational study of births to 115,502 individuals at 25 hospitals in the US from March 2008–February 2011. Data from 3123 individuals who gave birth to a non-anomalous …

Maternal Diabetes And Intrapartum Fetal Electrocardiogram, Beth A Plunkett, Steven J Weiner, George R Saade, Michael A Belfort, Sean C Blackwell, John M Thorp, Alan T N Tita, Russell S Miller, David S Mckenna, Edward K S Chien, Dwight J Rouse, Yasser Y El-Sayed, Yoram Sorokin, Steve N Caritis, Eunice Kennedy Shriver National Institute Of Child Health And Human Development Maternal-Fetal Medicine Units (Mfmu) Network

Faculty, Staff and Student Publications

Objective:

Fetal electrocardiogram (ECG) ST-changes are associated with fetal cardiac hypoxia. Our objective was to evaluate ST-changes by maternal diabetic status and stage of labor.

Methods:

Secondary analysis of a multi-centered randomized-controlled trial in which laboring patients with singleton gestations underwent fetal ECG scalp electrode placement and were randomly assigned to masked or unmasked ST-segment readings. Our primary outcome was the frequency of fetal ECG tracings with ST-changes by stage of labor. ECG tracings were categorized into mutually exclusive groups (ST-depression, ST-elevation without ST-depression or no ST-changes). We compared participants with pre-gestational diabetes mellitus (DM), gestational DM (GDM), and no …

Use Of Advanced Diagnostics For Timely Identification Of Travel-Associated Leptospira Santarosai Infection In Four Adolescents Through Plasma Microbial Cell-Free Dna Sequencing With The Karius Test, Hai Nguyen-Tran, Guliz Erdem, P Marcelo Laufer, Lori Patterson, Asim A Ahmed, William A Bower, Renee Galloway, Sara Saporta-Keating

Faculty, Staff and Student Publications

Background: Leptospirosis is an important zoonotic infection worldwide. Diagnosis of leptospirosis is challenging given its nonspecific clinical symptoms that overlap with other acute febrile illnesses and limitations with conventional diagnostic testing. Alternative advanced diagnostics, such as microbial cell-free DNA (mcfDNA), are increasingly being used to aid in the diagnosis of infections and can be applied to pathogens with public health importance such as Leptospira , a nationally notifiable disease.

Methods: The Karius Test uses plasma mcfDNA sequencing to detect and quantify DNA-based pathogens. This test offered through the Karius lab detected 4 cases of Leptospira santarosai during a 5-month period …

Simultaneous Hemorrhage And Venous Thrombosis In A Patient With Systemic Lupus Erythematosus, Binoy Yohannan, Natalie A Montanez, Miguel A Escobar

Faculty, Staff and Student Publications

No abstract provided.

Head-To-Head Comparison Of Relevant Cell Sources Of Small Extracellular Vesicles For Cardiac Repair: Superiority Of Embryonic Stem Cells, Hernán González-King, Patricia G Rodrigues, Tamsin Albery, Benyapa Tangruksa, Ramya Gurrapu, Andreia M Silva, Gentian Musa, Dominika Kardasz, Kai Liu, Bengt Kull, Karin Åvall, Katarina Rydén-Markinhuhta, Tania Incitti, Nitin Sharma, Cecilia Graneli, Hadi Valadi, Kasparas Petkevicius, Miguel Carracedo, Sandra Tejedor, Alena Ivanova, Sepideh Heydarkhan-Hagvall, Phillipe Menasché, Jane Synnergren, Niek Dekker, Qing-Dong Wang, Karin Jennbacken

Faculty, Staff and Student Publications

Small extracellular vesicles (sEV) derived from various cell sources have been demonstrated to enhance cardiac function in preclinical models of myocardial infarction (MI). The aim of this study was to compare different sources of sEV for cardiac repair and determine the most effective one, which nowadays remains limited. We comprehensively assessed the efficacy of sEV obtained from human primary bone marrow mesenchymal stromal cells (BM-MSC), human immortalized MSC (hTERT-MSC), human embryonic stem cells (ESC), ESC-derived cardiac progenitor cells (CPC), human ESC-derived cardiomyocytes (CM), and human primary ventricular cardiac fibroblasts (VCF), in in vitro models of cardiac repair. ESC-derived sEV (ESC-sEV) …

Stabilizing Histamine Release In Gut Mast Cells Mitigates Peripheral And Central Inflammation After Stroke, Tyler J Lefevre, Wenyuan Wei, Elizaveta Mukhaleva, Sai Pranathi Meda Venkata, Naincy R Chandan, Saji Abraham, Yong Li, Carmen W Dessauer, Nagarajan Vaidehi, Alan V Smrcka

Faculty, Staff and Student Publications

Highly homologous members of the Gαi family, Gαi1-3, have distinct tissue distributions and physiological functions, yet their biochemical and functional properties are very similar. We recently identified PDZ-RhoGEF (PRG) as a novel Gαi1 effector that is poorly activated by Gαi2. In a proteomic proximity labeling screen we observed a strong preference for Gαi1 relative to Gαi2 with respect to engagement of a broad range of potential targets. We investigated the mechanistic basis for this selectivity using PRG as a representative target. Substitution of either the helical domain (HD) from Gαi1 into Gαi2 or substitution of a single amino acid, A230 …

Challenges That Impact The Development Of A Multi-Generational Low-Carbon Passive House In A Small City, Hanan Wehbi, Tahar Messadi

Architecture Faculty Publications and Presentations

The impact of the building and construction sector on climate change is becoming more important and recognized. Multiple initiatives around the globe have been utilized to design and develop residential structures, aiming to reduce energy consumption and carbon emissions; yet, there are several barriers to effective construction processes. This research outlines the gaps and barriers encountered by key stakeholders that were engaged during the preconstruction phase of a three-story multi-generational low-impact Passive House in Fayetteville, Arkansas. Through direct observation and open-ended interviews, the primary data are collected, and secondary data from a comprehensive literature review are detailed to capture the …

Screening Of Orthodontic Patients And Age-Matched Non- Orthodontic Samples For High-Risk Oncogenic Human Papillomavirus (Hpv) Strains, Hunter Hinton

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: The human papillomavirus (HPV) is known to cause cancer in several tissues and organs, including the cervix and the oral cavity. Several oncogenic or high-risk strains have been identified, which include HPV16 and HPV18.However, other research has demonstrated that additional oncogenic, high-risk strains exist - including HPV31, HPV33, HPV35, HPV52 and HPV58, although much less is known about their prevalence. Based upon this lack of knowledge, the primary objective of this project is to address the prevalence of these strains among pediatric and adult patients through screening of saliva samples from the UNLV-SDM and orthodontic clinic populations.

Methods: The …

Osteoarthritis In The Temporomandibular Joint And Knee Joint: A Macroscopic Study Of Cadaver Specimens, Jeremy James

UNLV Theses, Dissertations, Professional Papers, and Capstones

In this study, thirty-one TMJs and twenty-eight knee joints were dissected from seventeen cadaveric subjects aged 69 to 95. Degenerative/osteoarthritic changes on the mandibular condyles, mandibular fossae, and femoral condyles were evaluated macroscopically and assigned a score on a disease severity scale (DSS) from 0 signifying “normal cartilage” to 4 signifying “severe OA”. Osteoarthritic changes were found in all TMJ and knee specimens. The average mandibular condyle DSS score was 2.68 ± 0.96, while the average mandibular fossa score was 2.90 ± 0.76; this difference in scores was significant (P = 0.035). Additionally, the mandibular fossa was equally or more …

Becoming A Bicultural High School Teacher In The United States: An Autoethnography Of A Latina Educator, Silvina Jover

UNLV Theses, Dissertations, Professional Papers, and Capstones

This research was guided by two autoethnographic questions, namely: How does autoethnography enable understanding of the needs of emergent bilinguals in the sociopolitical context of local and federal language policies in the United States? As well as extended by the following ancillary questions: a. What are the patterns and variations that emerge from journal entries crafted by the author of this study? And b. What are the patterns and variations that emerge from state and national news pieces between the years 2015 and 2020?

This narrative serves not only to present the challenges encountered within the field of multicultural education …

Persisting Inequity: School Administrators’ Social Dominance Orientation And Disciplinary Practices, Abigail Johnson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Empirical research has established that exclusionary discipline is applied to black students at a higher rate than white students for similar offenses, and that this disproportionality cannot be attributed to the severity or frequency of misconduct. Exclusionary discipline, which removes a student from the educational setting, poses significant challenges to academic and social well-being and introduces a host of proximal issues for black students. This dissertation draws upon Social Dominance Theory (SDT), which examines how beliefs aligned to existing hierarchies perpetuate discrimination and oppression, to explore how administrators' anti-egalitarian beliefs and disciplinary practices influence the disproportionate application of exclusionary discipline …

Comparative Evaluation Of Clinical Presentation And Management Of Equine Asthma By Climate Region, Tacey Davis

Honors College Theses

Equine asthma, including both mild and severe forms, is a prominent respiratory disease impacting the health and performance levels of affected horses. The objective of this study was to conduct a comprehensive assessment of a broad equine population, analyzing various disease aspects in relation to prevalence and severity across the nine climate regions in the United States. The methodology followed a survey-based research design, utilizing convenience and voluntary response sampling methods. Data collection involved 86 respondents across these regions. Quantitative and qualitative questions explored prevalence rates, diseases manifestation, risk factor of age, seasonality components, and diagnostic and management strategies from …

High-Altitude Ballooning And Payload Design, Matthew Smith

Honors College Theses

The Icarus project began in 2017 where a team performs high-altitude balloon (HAB) launches to conduct atmospheric and payload design research. The project involves sending a data-collecting payload containing recording equipment to high altitudes (~100,000 feet). This paper outlines the Icarus project as well as the efforts to design a payload that will remain stable throughout flight while also protecting the equipment housed within the payload shell. SOLIDWORKS computer-aided design (CAD) software was used to design a unique payload system. The payload parts were manufactured with PLA filament using a Prusa MK4 3D printer. The secondary goal of this thesis …

The Bridge Newsletter Spring 2024, Missouri University Of Science And Technology

The Bridge Newsletter

• ASCE MidAmerica Student Symposium
• Bridge team wins sixth consecutive competition
• White awarded 2024 Fulbright Prize
• El-Adaway inducted into ISU Hall of Fame
• Williams signs on with The Kansas City Glory Women’s National Football team

2024-05-01 Caudill Connection, Morehead State University. Caudill College Of Arts, Humanities And Social Sciences.

Caudill Connection

Caudill Connection newsletter for May of 2024.

Music Therapy Perspectives In Popayan By Music Graduates From The Universidad Del Cauca, Laura Piedad Parra Acosta

Theses & Dissertations

This research explored the perspectives of music graduates from the Universidad del Cauca in Popayán, Colombia, regarding music therapy. A questionnaire-based survey was conducted to gather data from participants, who were music educators and performers. Descriptive statistics were employed to analyze the responses and derive insights. Findings revealed varying levels of awareness and knowledge about music therapy among participants, with the majority expressing interest in gaining a further understanding of how to incorporate music therapy techniques into their practice. Moreover, participants emphasized the potential benefits of music therapy for emotional well-being and mental health in educational and performance settings. This …

The Experience Of An Autistic And Neurotypical Sibling Dyad In Improvisational Music Therapy, Gianna Derusso

Theses & Dissertations

The purpose of this study was to explore the sibling relationship within improvisational music therapy, specifically the relationship between an autistic sibling and a neurotypical sibling. The following research question was posed: How does the relationship between a neurotypical and autistic sibling dyad present in improvisational music therapy? Subquestions to the research questions included: How do a neurotypical and autistic sibling dyad interact with one another within an improvisational music therapy session?, and How do a neurotypical and autistic sibling dyad interact with the music therapist within an improvisational music therapy session? An autistic and neurotypical sibling dyad was recruited, …

The Experience Of Home-Based Music Therapists Working With Individuals With Intellectual And Developmental Disabilities: A Thematic Analysis, Sarah Mayr

Theses & Dissertations

According to the Administration for Community Living (ACL), an estimated 7.38 million people in the United States live with an intellectual and/or developmental disability (2021). Many individuals with intellectual and developmental disabilities (I/DDs) reside in community-based settings, such as private residences, family members’ homes, or group homes (ACL, 2021). However, little research exists exploring home-based music therapy (HBMT) for people with I/DD, especially from the clinician’s perspective. Thus, this study examines the experiences of home-based music therapists working with individuals with I/DD to provide a foundational overview. Three music therapists working in home-based settings participated in semi-structured guided interviews, which …

Exploring Music Therapists' Experiences Of Utilizing A Family-Based Approach With Children Receiving Palliative Care, Faith Anne Agolia

Theses & Dissertations

This research study explored the experiences of three music therapists who employ a family-based approach with families whose children are receiving palliative care. Literature addressing the benefits of music therapy for people in palliative care exists, but little is known about the lived experience of music therapists who work in these settings. Music therapists were recruited through purposive sampling. Through phenomenological microanalysis, eight themes emerged: Family-based approach is natural, yet nuanced; the sacredness of the therapeutic relationship; positive memory making through legacy as a means to family connectedness; vicarious trauma; intentional self-care and coping; feeling siloed and experiencing challenges within …

Comparing The Impact Of Client-Led Music Therapy With Autistic Clients Enrolled In An Applied Behavior Analysis Program Versus Those In Standard Care, Annie Fitzgerald

Theses & Dissertations

This study investigates the efficacy of client-led music therapy as a complementary intervention for enhancing aspects of social and behavioral functioning in autistic children enrolled in applied behavior analysis (ABA) programs compared to those in standard care. Utilizing a quantitative approach with pre- and post-intervention assessments, the study evaluates changes across categories of Social Communication, Social Cognition, Social Awareness, Social Motivation, and Restricted Interests and Repetitive Behaviors using the Social Responsiveness Scale-2 (SRS-2). Findings reveal no statistically significant differences in pre- to postintervention scores for either group, yet promising trends emerge. In the study, child-led music therapy within ABA interventions …

Experiences In Vocal Psychotherapy Of A Music Therapy Intern With Post-Covid Symptoms, Kyungwon Matilda Choi

Theses & Dissertations

The purpose of this study was to explore my experiences in vocal psychotherapy as a music therapy intern with Long COVID symptoms. This study employed a first-person qualitative research design by assessing two personal therapy sessions with heuristic inquiry. I analyzed my experience as a client receiving 60-minute individual vocal psychotherapy sessions. The music therapist was a trained (certified) vocal psychotherapist with at least five years of clinical practice. Data were collected from recorded session audio/video and personal journals. The recorded session audio/video were transcribed so the data could be analyzed. I asked and answered the research questions as this …

The Role Of Cosmopolitan Orientation In Covid-19-Related Attitudes: Perceived Threats And Opportunities, Vaccination Willingness, And Support For Collective Containment Efforts, Angela K. Y. Leung, Brandon Koh, Verity Yu Qing Lua, James H. Liu, Sarah Y. Choi, I-Ching Lee, Michelle Lee, Mei-Hua Lin, Darrin Hodgetts, Sylvia X. Chen

Research Collection School of Social Sciences

Cosmopolitan individuals identify themselves as "citizens of the world." In the present research, we tested the idea that endorsing a cosmopolitan orientation (CO) is adaptive in the COVID-19 crisis. Cosmopolitan individuals more readily transcend national parochialism, show greater concern for all humanity, and prioritize collective interests. In a two-wave multi-region investigation with six samples from China, Hong Kong, Taiwan, Malaysia, Singapore, and the U.S., we first established longitudinal and cross-cultural measurement invariance of the CO scale. Next, we found that people with a higher CO tended to perceive over time a greater threat posed by COVID-19, take more safety measures, …

Determination Of Factors Influencing Microbial Food Safety Risks Of Additive Manufacturing And 3d Printing Of Food, Allyson Nichole Hamilton

Graduate Theses and Dissertations

The burgeoning field of 3D food printing introduces opportunities for customizing the physicochemical properties of food, offering tailored solutions in color, shape, and texture. Despite its potential, the implications of this technology on food safety, particularly the efficacy of manufacturer-recommended cleaning protocols for stainless steel food ink capsules, the transferability of pathogens from a contaminated food ink capsule into the food ink based on macronutrient composition of the food, and the impact of storage conditions on pathogen viability, have not been thoroughly investigated. This dissertation provides a comprehensive analysis of these aspects, focusing on the control of foodborne pathogens and …

Salafi Reformist Fatwas And The Challenge To Traditionalism In Egypt And Arabia, 1895 – 1930, Samuel Scurry

Graduate Theses and Dissertations

Studies of the Islamic intellectual movement commonly known as Salafism have long focused either on the modernist reformers in Egypt and Syria in the late nineteenth and early twentieth centuries, or on the far more austere and sometimes militant iterations of Salafism from the mid-twentieth century to the present day, often associated with Wahhabism. A handful of scholars have examined the links between the two and the transition from the earlier to the later Salafis, however many works which impacted the evolution of Salafism at the dawn of the twentieth century have been neglected, especially those which do not align …

Exploring The Governmental Intervention, Journalistic Approach, And Theories Involved In Reducing Poverty Journalistic For A Special Project – Feature Story On Non-Profit Organization Called Circles In Northwest Arkansas, Trevor Spencer

Graduate Theses and Dissertations

Over the 60 years since President Johnson declared the War on Poverty, with close to 40 million people currently in poverty nationwide as of 2022, government measures of the issue, like the Federal Poverty Level and Supplementary Poverty Measure, have continued to be significant determiners for who is constituted as poor. Yet, framing of the poor by sociologists has shifted to a more multi-dimensional approach to who constitutes as poor and how to help them. This means that the definition of poverty is beginning to include a larger set of deprivation unaccounted for in a nation where the definition of …

From Stardom To Stunted: The Rise And Fall Of Sports Icons, Julia Simone

Undergraduate Theses and Capstone Projects

This case study is an examination of Aaron Hernandez’s professional and personal life as it was portrayed in the media. This study seeks to examine how the media narrative changed for Hernandez after his criminal activities came to light and how sports media contributed to the rise and fall of Aaron Hernandez’s professional career. The study also aimed to examine how stars like Hernandez can be held accountable for their actions outside their respective sport. To accomplish these goals, the researcher examined media coverage surrounding Hernandez to uncover how media frames corresponded with and contributed to the rise and fall …

Collateral Consequences: The Effects Of Justice Processing For Violations Of Drug Laws In New York City, John K. Roman, Gregory Haugan, Benjamin Schapiro, Sofia Rodriguez

Publications and Research

As part of the NYC Police Reform and Reinvention Collaborative, the Mayor’s Office of Criminal Justice partnered with the Research and Evaluation Center at John Jay College and the National Opinion Research Center (NORC) at the University of Chicago to examine economic factors related to drug-related crimes and arrests. Focusing on Task 84 of the Reform Initiative Tracker, NORC researchers analyzed public data to explore how neighborhood-level economic indicators, such as property values and tax assessments, correlate with drug-related criminal justice contacts. The study supports ongoing efforts to implement and monitor reforms across New York City.

Mattie Castlebury: East Texas Oil Boom Legend, Olivia L. Moore

Electronic Theses and Dissertations

The discovery of the East Texas Oil Field in 1930 was a pivotal moment, reshaping the region’s economic and social dynamics. Mattie Castlebury emerged as a standout figure among the fervor of the oil boom, leaving an indelible mark on East Texas’ cultural identity. Castlebury’s story showcases resilience and resourcefulness as she navigated the challenges of the oil boom era. She established Mattie’s Ballroom, creating a bustling leisure and entertainment hub.Through her entrepreneurial strategies, Castlebury’s impact on the community is evident, shaping East Texas’ cultural fabric.

The “Women of the Boom” exhibition at the Kilgore College East Texas Oil Museum …

Special Anatomy Series. Imaging Inner Ear Structures With High-Frequency Ultrasound: Application To Physical Rehabilitation Space Medicine., Jeffrey Strakowski, Han Zhang, Millard Reschke, Faye Y Chiou-Tan

Neuroscience Articles

OBJECTIVE: The objective of this paper is to document the feasibility of image acquisition, image optimization, and sonographic appearance of the exposed anatomic windows of cadaveric inner ear dissection for purposes of potential future clinical evaluation as part of the developing area of physical and rehabilitation space medicine.

METHODS: Cadaveric dissection of the inner ear was conducted with the goal of exposing areas relevant to vestibular balance. Middle and inner ear structures of 3 human cadavers were imaged with multiple broadband transducers, including emphasis with higher frequency transducers.

RESULTS: The images were best optimized with 17 MHz and 22 MHz …