Digital Commons Network^™

Un Ésprit Sérieux, Pierre Schlag

Dalhousie Law Journal

It was a sunny day when we all met in a classroom at McGill University The gathering went on all day and at the end someone proposed writing up the discussion as essays. Hence, this collection.

I’d like to take a moment of gratitude to express heartfelt thanks to all the participants. And especially to Vincent Forray and Jean d’Aspremont for organizing the event, and to Genevieve Renard Painter and Liam McHugh-Russell for bringing this collection over the finish line. I don’t know whether the intellectual generosity of the participants was because of Canada, or Montreal, or McGill, or the …

Length Of Time Differences Between Genders In Factors Of Movement From Suicidal Ideation To Suicidal Action, Carina Anderson

Doctor of Psychology (PsyD)

While women are more likely to take suicidal action, men are more likely to die of it. This difference has been partially, but not completely explained by the methods of suicide generally chosen by men and women. While this and other factors have been explored, there is no conclusive answer for the difference in death rates. Research suggests that men and women make decisions differently, and if these differences contribute to variations in their movement from suicidal ideation to suicidal action, we might expect to see these differences reflected in the amount of time it takes men and women to …

Foxo1 Inhibitor, As1842856, Induces Cell Cycle Arrest And Reverses Anticancer Drug-Induced Cytotoxicity In Osteosarcoma Cells, Antanay Hall

Theses (2016-Present)

Forkhead box class O (FOXO)-1 transcription factor controls cell proliferation, apoptosis, oxidative stress, and other cellular activities; FOXO1 has also been implicated in cell cycle regulation. This research project aims to determine the contribution of FOXO1 to cell cycle regulation and response to anticancer drug treatment in osteosarcoma. Osteosarcoma is the most common bone cancer, with most cases occurring in people younger than 30 years old. The study explores the impact of FOXO1 inhibitor AS1842856 on the cytotoxic effects of anticancer drugs in CCHOSD, Hos, and LM7 osteosarcoma (OGS) cell lines. Following chemical inhibition of FOXO1 and anticancer drug treatment, …

Inhibition Of Foxo Induces Oxidative Stress In Osteosarcoma, Kai K. Brown

Theses (2016-Present)

Redox homeostasis is a balance between reactive oxygen species (ROS) generation and neutralization by antioxidants. Oxidative stress (OS) results when the generation of ROS exceeds the neutralizing capacity of endogenous antioxidants. Reactive oxygen species are generated during cellular processes such as mitochondrial activity or metabolism of drugs. Expression of endogenous antioxidants is driven by redox-sensitive transcription factors; therefore, redox-sensitive transcription factors are essential for the maintenance of cellular redox homeostasis. There are several redox-sensitive transcription factors that contribute to the expression of endogenous antioxidants. These redox-sensitive transcription factors include nuclear factor erythroid 2-related factors (Nrf-2), hypoxia-inducible factor (HIF), activator protein-1 …

Experimental Analysis Of Mybl1, Vcpip1 And Ubxn2b In Triple Negative Breast Cancers, Fawaz Opeyemi Ibikunle

Theses (2016-Present)

The focus of our laboratory is to characterize triple negative breast cancers. In a previous study we identified six genes over-expressed in a subset of the cancers. MYBL1 was one of the genes. MYBL1 is a strong transcriptional activator responsible for regulation of genes associated with cell cycle signaling, differentiation and apoptosis, all processes that drive cancers. Because of MYBL1’s involvement in processes key to cancer pathogenesis, in an earlier study, we knocked down the MYBL1 gene in efforts to identify genes that were either directly or indirectly associating with the gene to affect the triple negative breast cancer processes. …

Evaluation Of Wogonin And Chrysin In Alleviating Mycophenolate-Induced Diarrhea And Its Pharmacokinetics Profile, Abasifreke Sunday Benson

Theses (2016-Present)

Medication-induced diarrhea is a common adverse effect experienced by patients taking immunosuppressant medications used in Organ transplants. However, Mycophenolate mofetil (MMF) is the first-line drug to prevent organ transplant rejection. (Van Gelder & Hesselink, 2015) . MMF’s mechanism of action involves inhibition of inosine-5'-monophosphate dehydrogenase. It is used for the treatment and management of a variety of autoimmune diseases as well as to prevent organ rejection in patients with bone marrow and solid organ transplants; however, over 50% of its adverse effects have been reported to be diarrhea. (Arslan et al., 2007; Farooqi et al., 2020). However, few options exist …

Reconstructing The Narrative Of Slavery In The United States: Acknowledging The Complex Exploitation Of Forced, Free, And Semi-Free Labor Beyond Race And Ethnicity And The Several Communities Who Endured Systemic Labor Exploitation And Injustice In The United States, Amma Terrece Sims

Theses (2016-Present)

This thesis explores the deconstruction and modernization of the narrative surrounding slavery in the United States by recognizing the multifaceted exploitation of labor beyond racial limitations. Through an assessment of representations and historical instances of forced, free, and semi-free labor in the United States, this study explores various forms of systemic subjugation and discrimination endured by diverse communities of immigrants. Specific consideration is given to examples such as indentured servitude of the colonial era and the experiences of “new immigrants” of the industrial period in challenging the established racial paradigm correlated with slavery. The experiences of specific European ethnic sub- …

Workplace Wellness, Hannah Holder

Management Undergraduate Honors Theses

The evolving landscape of workplace dynamics underscores a growing emphasis on achieving a better work-life balance and healthier lifestyle, particularly among younger generations entering the workforce. This shift in preferences highlights the importance of companies adapting to meet the needs of employees by offering flexibility and support for wellness initiatives. A workplace culture that promotes work-life balance not only enhances employee satisfaction but also leads to increased productivity and decreased healthcare costs. While comprehensive wellness programs and flexible work arrangements are beneficial, they may not be universally applicable. However, the overarching commitment to creating a supportive and healthy work environment …

Genome-Wide Association Study/ Genomic Prediction Of Cowpea Seed Protein And Black Seed Coat Color In Cowpea, Yilin Chen

Graduate Theses and Dissertations

Cowpea (Vigna unguiculata [L.] Walp) is a crucial crop in many regions, serving as a vital protein source for humans and livestock. Addressing the need to enhance its nutritional quality and make it easier to cultivate cowpeas of specific colors, this study utilized genome-wide association studies (GWAS) to identify markers associated with protein content and seed coat color patterns in cowpea.

In the protein content study, a GWAS was conducted on 161 cowpea accessions using 110,155 high-quality single-nucleotide polymorphisms (SNPs). Seven significant SNP markers were identified, all located at a locus on chromosome 8 associated with the gene Vigun08g039200, enhancing …

Exploring Binding Pockets In The Conformational States Of The Sars-Cov-2 Spike Trimers For The Screening Of Allosteric Inhibitors Using Molecular Simulations And Ensemble-Based Ligand Docking, Grace Gupta, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Understanding mechanisms of allosteric regulation remains elusive for the SARS-CoV-2 spike protein, despite the increasing interest and effort in discovering allosteric inhibitors of the viral activity and interactions with the host receptor ACE2. The challenges of discovering allosteric modulators of the SARS-CoV-2 spike proteins are associated with the diversity of cryptic allosteric sites and complex molecular mechanisms that can be employed by allosteric ligands, including the alteration of the conformational equilibrium of spike protein and preferential stabilization of specific functional states. In the current study, we combine conformational dynamics analysis of distinct forms of the full-length spike protein trimers and …

Explaining Misinformation Detection Using Large Language Models, Vishnu S. Pendyala, Christopher E. Hall

Faculty Research, Scholarly, and Creative Activity

Large language models (LLMs) are a compressed repository of a vast corpus of valuable information on which they are trained. Therefore, this work hypothesizes that LLMs such as Llama, Orca, Falcon, and Mistral can be used for misinformation detection by making them cross-check new information with the repository on which they are trained. Accordingly, this paper describes the findings from the investigation of the abilities of LLMs in detecting misinformation on multiple datasets. The results are interpreted using explainable AI techniques such as Local Interpretable Model-Agnostic Explanations (LIME), SHapley Additive exPlanations (SHAP), and Integrated Gradients. The LLMs themselves are also …

Assessing The Impact Of Spraying An Enterococcus Faecium-Based Probiotic On Day-Old Broiler Chicks At Hatch On The Incidence Of Bacterial Chondronecrosis With Osteomyelitis Lameness Using A Staphylococcus Challenge Model, Anh Dang Trieu Do, Amanda Anthney, Khawla Alharbi, Andi Asnayanti, Antoine Meuter, Adnan Ali Khalaf Alrubaye

Poultry Science Faculty Publications and Presentations

Bacterial chondronecrosis with osteomyelitis (BCO) lameness is a bone disease characterized by the translocation of bacteria from the gastrointestinal tract, which colonize microfractures in broiler leg bones caused by rapid animal growth rate and weight gain, resulting in lameness. As such, BCO lameness represents a significant challenge for the poultry industry. This study aims to evaluate the effect of spraying broiler chicks on d0 at hatch with an Enterococcus faecium probiotic on the incidence of BCO-induced lameness, utilizing a Staphylococcus aureus challenge model. There were four treatments: (1) negative control (no probiotic + no challenge, NC); (2) positive control (no …

Genetic Dissection Of Diverse Seed Coat Patterns In Cowpea Through A Comprehensive Gwas Approach, Haizheng Xiong, Yilin Chen, Waltram Ravelombola, Beiquan Mou, Xiaolun Sun, Qingyang Zhang, Yiting Xiao, Yang Tian, Qun Luo, Ibtisam Alatawi, Kenani Edward Chiwina, Hanan Mohammedsaeed Alkabkabi, Ainong Shi

Poultry Science Faculty Publications and Presentations

This study investigates the genetic determinants of seed coat color and pattern variations in cowpea (Vigna unguiculata), employing a genome-wide association approach. Analyzing a mapping panel of 296 cowpea varieties with 110,000 single nucleotide polymorphisms (SNPs), we focused on eight unique coat patterns: (1) Red and (2) Cream seed; (3) White and (4) Brown/Tan seed coat; (5) Pink, (6) Black, (7) Browneye and (8) Red/Brown Holstein. Across six GWAS models (GLM, SRM, MLM, MLMM, FarmCPU from GAPIT3, and TASSEL5), 13 significant SNP markers were identified and led to the discovery of 23 candidate genes. Among these, four specific …

Potential Non-Invasive Detection Of Lesions In Broiler Femur Heads: Application Of The Dxa Imaging System, Alison Ramser, Elizabeth Greene, Robert Wideman, Sami Dridi

Poultry Science Faculty Publications and Presentations

Leg health is a significant economic and welfare concern for the poultry industry. Current methods of detection rely on visual assessment of the legs and gait scores and bone scoring during necropsy for full characterization. Additionally, the current scoring of femurs only examines the external surface of the femoral head. Through the use of the dual-energy X-ray absorptiometry (DXA) imaging system, we show the presence of a necrotic region in the femurs that would otherwise be considered healthy based on the current evaluation procedures. Importantly, these lesions were present in almost 60% (22 of 37) of femurs that scored normal …

Effects Of Nicotinamide Riboside In Ovo Feeding On High-Yield Broiler Performance, Meat Quality, And Myopathy Incidence, Clay J. Maynard, John M. Gonzalez, Taketo Haginouchi, Olivia G. Ellis, Ashunti R. Jackson, Casey M. Owens

Poultry Science Faculty Publications and Presentations

Introduction: The objective of this study was to examine the effects of in ovo nicotinamide riboside (NR) feeding on high-yield broiler growth and meat quality.

Methods: Fertilized Cobb 700 by-product eggs (N = 3,240) were randomly assigned to one of four in ovo treatments and injected with 0 (0NR), 250 (250NR), 500 (500NR), or 1,000 (1,000NR) mM NR at incubation-day 10. Chicks were hatched, vent sexed, and randomly placed 18 per pen in one of 32 floor pens. On day 48, birds were processed and deboned.

Results: There were dose effects …

The Hepatokine Orosomucoid 2 Mediates Beneficial Metabolic Effects Of Bile Acids, Sung Ho Lee, Ji Ho Suh, Mi Jeong Heo, Jong Min Choi, Yang Yang, Hyun-Jung Jung, Zhanguo Gao, Yongmei Yu, Sung Yun Jung, Mikhail G Kolonin, Aaron R Cox, Sean M Hartig, Holger K Eltzschig, Cynthia Ju, David D Moore, Kang Ho Kim

Faculty, Staff and Student Publications

Bile acids (BAs) are pleiotropic regulators of metabolism. Elevated levels of hepatic and circulating BAs improve energy metabolism in peripheral organs, but the precise mechanisms underlying the metabolic benefits and harm still need to be fully understood. In the current study, we identified orosomucoid 2 (ORM2) as a liver-secreted hormone (i.e., hepatokine) induced by BAs and investigated its role in BA-induced metabolic improvements in mouse models of diet-induced obesity. Contrary to our expectation, under a high-fat diet (HFD), our Orm2 knockout (Orm2-KO) exhibited a lean phenotype compared with C57BL/6J control, partly due to the increased energy expenditure. However, when challenged …

Patient Priorities Care Increases Long-Term Service And Support Use: Propensity Match Cohort Study, Rafael Samper-Ternent, Javad Razjouyan, Lilian Dindo, Jaime Halaszynski, Jennifer Silva, Terri Fried, Aanand D Naik

Faculty, Staff and Student Publications

OBJECTIVES: Patient priorities care (PPC) is an evidence-based approach designed to help patients achieve what matters most to them by identifying their health priorities and working with clinicians to align the care they provide to the patient's priorities. This study examined the impact of the PPC approach on long-term service and support (LTSS) use among veterans.

DESIGN: Quasi-experimental study examining differences in LTSS use between veterans exposed to PPC and propensity-matched controls not exposed to PPC adjusting for covariates.

SETTING AND PARTICIPANTS: Fifty-six social workers in 5 Veterans Health Administration (VHA) sites trained in PPC in 2018, 143 veterans who …

Advancing Genomics To Improve Health Equity, Ebony B Madden, Lucia A Hindorff, Vence L Bonham, Tabia Henry Akintobi, Esteban G Burchard, Kellan E Baker, Rene L Begay, John D Carpten, Nancy J Cox, Valentina Di Francesco, Denise A Dillard, Faith E Fletcher, Stephanie M Fullerton, Nanibaa' A Garrison, Catherine M Hammack-Aviran, Vanessa Y Hiratsuka, James E K Hildreth, Carol R Horowitz, Chanita A Hughes Halbert, Michael Inouye, Amber Jackson, Latrice G Landry, Rick A Kittles, Jeff T Leek, Nita A Limdi, Nicole C Lockhart, Elizabeth O Ofili, Eliseo J Pérez-Stable, Maya Sabatello, Loren Saulsberry, Lorjetta E Schools, Jennifer L Troyer, Benjamin S Wilfond, Genevieve L Wojcik, Judy H Cho, Sandra S-J Lee, Eric D Green

Center for Medical Ethics and Health Policy Staff Publications

Health equity is the state in which everyone has fair and just opportunities to attain their highest level of health. The field of human genomics has fallen short in increasing health equity, largely because the diversity of the human population has been inadequately reflected among participants of genomics research. This lack of diversity leads to disparities that can have scientific and clinical consequences. Achieving health equity related to genomics will require greater effort in addressing inequities within the field. As part of the commitment of the National Human Genome Research Institute (NHGRI) to advancing health equity, it convened experts in …

Dynamic Compressive Properties Of Heat-Treated And Pre-Stressed Cement Mortar Specimen Subjected To Cyclic Impact Loading, Ronghua Shu, Guang Xu, Lijinhong Huang

Mining Engineering Faculty Research & Creative Works

By carrying out the cyclic dynamic compressive experiment, the dynamic compressive properties of heat-treated and pre-stressed cement mortar subjected to cyclic impact loading were obtained. The results show that under static and cyclic impact loading, the peak stress shows a nonlinear decrease trend with the increasing dynamic impact number, and the failure strength decreases as heated temperature increases. The strain rate shows a linear increase trend as impact number increases. The relationship among the strain rate, temperature and impact number obey exponential relations, which could be expressed as ε˙ = 0.64E0.00854T+4.93 X 10−3tn+0.77N+18.70. The strain rate increase factor could be …

The Interplay Of Casing Material And Detonation Wave Shock Parameters In Steel Witness Plate Dent Formation, Emily M. Johnson, Catherine E. Johnson

Mining Engineering Faculty Research & Creative Works

This Study Uses Both Experimentation and Simulation to Investigate How Varying Casing Material Around Cylindrical Composition-B Charges Affects Witness Plate Response and Diagnoses the Cause of the Differences in the Dents Produced. through Experimentation, It Was Found that Consistent Dents Are Produced from Repeated Tests and Characteristically Different Dents Are Produced by Charges with Different Casing Material. Charges Cased in Viscoelastic Materials Produced Shallower Dents Than Those Without Casing. Simulation Was Validated Against the Experimental Dents, and the Detonation Wave Parameters Were Measured for 25 Differently Cased Charges: 15 Metals and 10 Polymers. Regression Fit Relationships Were Derived Relating Dent …

Judges Should Be Discerning Consensus, Not Evaluating Scientific Expertise, David S. Caudill, Harry Collins, Robert Evans

Faculty Publications

One of the most constructive critiques of the Daubert admissibility regime is Professor Edward Cheng’s recent proposal for a new Consensus Rule in the Federal Rules of Evidence. Rejecting the notion that judges and juries have the capacity to evaluate scientific expertise, Cheng’s proposal would eliminate Daubert hearings—and judicial gatekeeping concerning expert testimony—and require judges and juries, in their verdicts, to follow consensus in the relevant scientific community. Significantly, Cheng argues that judges and juries would have an easier time identifying consensus than they have in deciding between experts who disagree.

We find Cheng’s emphasis on consensus compelling, and …

A Sensor-Based Simulation Method For Spatiotemporal Event Detection, Yuqin Jiang, Andrey A. Popov, Zhenlong Li, Michael E. Hodgson, Binghu Huang

Faculty Publications

Human movements in urban areas are essential to understand human–environment interactions. However, activities and associated movements are full of uncertainties due to the complexity of a city. In this paper, we propose a novel sensor-based approach for spatiotemporal event detection based on the Discrete Empirical Interpolation Method. Specifically, we first identify the key locations, defined as “sensors”, which have the strongest correlation with the whole dataset. We then simulate a regular uneventful scenario with the observation data points from those key locations. By comparing the simulated and observation scenarios, events are extracted both spatially and temporally. We apply this method …

Fatigue Impacts Quality Of Life In People With Spinocerebellar Ataxias, Ruo-Yah Lai, Christian Rummey, Christian J Amlang, Chi-Ying R Lin, Tiffany X Chen, Susan Perlman, George Wilmot, Christopher M Gomez, Jeremy D Schmahmann, Henry Paulson, Sarah H Ying, Chiadi U Onyike, Theresa A Zesiewicz, Khalaf O Bushara, Michael D Geschwind, Karla P Figueroa, Stefan M Pulst, Sub H Subramony, Matthew R Burns, Puneet Opal, Antoine Duquette, Tetsuo Ashizawa, Ali G Hamedani, Marie Y Davis, Sharan R Srinivasan, Lauren R Moore, Vikram G Shakkottai, Liana S Rosenthal, Sheng-Han Kuo

Faculty, Staff and Students Publications

Background: Fatigue is a prevalent and debilitating symptom in neurological disorders, including spinocerebellar ataxias (SCAs). However, the risk factors of fatigue in the SCAs as well as its impact have not been well investigated.

Objectives: To study the prevalence of fatigue in SCAs, the factors contributing to fatigue, and the influence of fatigue on quality of life.

Methods: Fatigue was assessed in 418 participants with SCA1, SCA2, SCA3, and SCA6 from the Clinical Research Consortium for the Study of Cerebellar Ataxia using the Fatigue Severity Scale. We conducted multi-variable linear regression models to examine the factors contributing to fatigue as …

The Utilization Of Music And Autonomous Sensory Meridian Response In Reducing Stress, Robert Scott

Electronic Theses, Projects, and Dissertations

Stress is often identified as a “silent killer” and the negative impact on one’s mental and physical well-being is greatly impacted without intervention. This study sought to determine which form of coping, autonomous sensory meridian response (ASMR) or music, is an effective strategy for reducing stress. The study was conceptualized using the positivist paradigm of research. An electronic survey was dispersed to participants via the website SurveyMonkey. Descriptive data was collected using demographic information gathered during the first portion of the survey. Participants’ self-identified stress levels were gathered before and after they viewed their randomly assigned coping strategy (ASMR or …

Accessibility Of Services For Transgender Adolescents From A Child Welfare Perspective, Eduardo Cedeno

Electronic Theses, Projects, and Dissertations

The following is a quantitative study with an explorative element conducted at Southern California University with a convenience sample of 23 social worker participants with experience in child welfare. A Qualtrics questionnaire was administered during the Fall 2023 semester and was used to assess the social workers perception, preparedness, and knowledge in providing services to transgender youth in foster care. The study aimed to gain an understanding of the overall perception of the effect in available transgender resources and training within the child welfare system.

Seeking Steatite: Analyzing The Spatial Distribution Of Southern California Arrow Shaft Straighteners, Christina Angela Livingston

Electronic Theses, Projects, and Dissertations

Arrow shaft straighteners are ground stone tools used in the production of arrows. Over the years, before Spanish colonialism, California Natives formed arrow shaft straighteners using various types of stone, such as granite or basalt. My thesis will focus on the arrow shaft straighteners made out of steatite. Steatite, or soapstone, is a metamorphic rock that is smooth to the touch. The smoothness makes steatite very easy to carve and modify. In California, there are many main sources of steatite. For my thesis, I will focus only on four of these sources: Inyo County, Santa Catalina Island, Sierra Pelona, and …

Examining The Effectiveness Of Psychosocial Interventions For Opioid Use Disorder: A Systematic Review, Elizabeth Ashley Contreras

Electronic Theses, Projects, and Dissertations

Background: Due to the increased distribution of synthetic opioids, mortality rates, overdose rates, and addiction related to the consumption of illicit fentanyl have drastically increased over the past years. Although medication-assisted treatment (MAT) is the first-line intervention for Opioid Use Disorder (OUD), less is known about the effectiveness of psychosocial interventions for treating this disorder. Objective: This study aimed to systematically review the literature on psychosocial interventions for treating OUD. Methods: A search was conducted on OneSearch using the keywords “opioid treatment” or “Fentanyl treatment” combined with “psychosocial interventions” or “cognitive behavioral therapy,” or “contingency management” for English articles published …

Distribution And Conveyance Of Late Prehistoric Western Mojave Obsidian Artifacts, Nicholas James Shepetuk

Electronic Theses, Projects, and Dissertations

There is a significant lack of publication, synthesis, and analysis of existing Late Prehistoric obsidian artifact sourcing data in the western Mojave Desert. However, a wealth of such data exists, especially in non-published archaeological reports produced mainly by cultural resources management firms. The purpose of this study was to test the validity of two regions which are divided roughly by the Mojave River and which are based on Sutton’s (1989) interaction sphere model. The Northwestern Region occupies the portion of the Mojave Desert to the north and west of the Mojave River, while the Eastern Region makes up the area …

Parent Involvement And Educational Outcomes Among Latino Families, Diana Garcia, Gabriela Munoz

Electronic Theses, Projects, and Dissertations

Parent involvement has been identified as a vital factor in determining children's success in school and life. Research has largely shown that direct parent involvement improves grades and graduation rates. Research has also shown that the major factors contributing to parent involvement are socioeconomic status and educational attainment. This study explores what prevents Latino parents from effectively engaging in their children's high school education. For Latinos, parent involvement is a struggle due to significant barriers to higher education system knowledge, level of parental acculturation, and technology limitations. This study used a quantitative descriptive approach. The researchers created a survey instrument …

Child Maltreatment Primary Prevention Methods In The U.S.: A Systematic Review Of Recent Studies, Maria Godoy-Murillo

Electronic Theses, Projects, and Dissertations

Background: Child maltreatment remains a widespread issue in the United States of America, (U.S.). Identifying effective methods of preventing child maltreatment is key to reducing the prevalence of this issue. Objective: This systematic review provides an overview of contemporary primary child maltreatment prevention methods in the U.S. to investigate their effectiveness. Methods: Using the OneSearch database, the following keywords were included: (“prevention methods” and “child maltreatment”), (“parental leave” and “child maltreatment”), (“primary prevention” and “child maltreatment”), (WIC and “child maltreatment”), (“home visit” and “child maltreatment”), (“child abuse and neglect” and “primary prevention”), (“affordable housing” and prevention and “child maltreatment”), (“early …