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Reclassifying Papillary, Oncocytic And Chromophobe Renal Tumours Based On The 5th Who Classification 2022, Nilofar Shaikh, Mary Mathew

Open Access archive

Objective: The classification of renal tumors is expanding with the addition of new molecular entities in the 5th World Health Organization classification. Apart from this, the major updates in the definition of papillary renal cell carcinoma are that these tumors are no longer subtyped into type 1 and type 2. In oncocytic tumors, the new molecularly defined renal tumors, emerging and novel entities need to be considered in the diagnosis of oncocytic and chromophobe renal tumors. Material and Methods: This is a retrospective study to review and reclassify papillary, oncocytic, and chromophobe renal tumors based on the new WHO classification …

Role Of Serum And Urine Neutrophil Gelatinaseassociated Lipocalin As Biomarkers For Assessing Graft Function In Kidney Transplant Recipients, Shankar Prasad Nagaraju, Shilna Muttickal Swaminathan, Shruti Bhattacharya, Ravindra Prabhu Attur

Open Access archive

Objectives: The existing biomarkers used to promptly identify graft dysfunction after kidney transplantation lack consistency. Neutrophil gelatinase-associated lipocalin (NGAL) appears to be a promising biomarker but its levels measured from serum and urine have demonstrated varying predictive values. Our study aimed to explore the potential of NGAL as a biomarker in predicting graft dysfunction in kidney transplant patients, including live and deceased donor recipients. Methods: A single-centered observational cohort study with live and deceased kidney recipients as participants was conducted between 2018 and 2022 at a tertiary care hospital in Southern India. Serum creatinine levels were monitored daily; creatinine reduction …

Role Of Endoscopic Ultrasound In The Management Of Pancreatic Cancer, Balaji Musunuri, Shiran Shetty

Open Access archive

Pancreatic cancer is one of the common causes of cancer-associated mortality with a dismal overall prognosis which has remained virtually unchanged over decades. In the present era, the management of patients with pancreatic cancer involves a multi-disciplinary team of radiologists, gastroenterologists, surgical oncologists, medical oncologists, radiation oncologists and other specialists. The advancement of interventional endoscopy has made a significant impact in the management of pancreatic cancers. Since the inception of endoscopic ultrasound, it has evolved over the last few decades in the management of pancreatic malignancies and its role in staging and tissue acquisition is well established. There is an …

Trajectory Analysis Of Circulating Tumor Cells Through Contorted Deterministic Lateral Displacement Array For Unruptured Trapping: A Simulation Study, Rituraj Bhattacharjee, R. Kumar

Open Access archive

During the multistage process of cancer spread, fragments of cells branch out from the primitive tumor tissue and scatter throughout the body by blood flow stream or lymph, which are termed as circulating tumor cells (CTCs), regarded as an important biomarker for early cancer diagnosis. Deterministic lateral displacement (DLD) is one of the most efficient passive type particle isolation techniques which functions on asymmetrical laminar flow diversion around the placed microposts forming an array, based on the critical dimeter of the device. In this simulation study, complete trajectory analysis of CTCs and WBCs has been performed using COMSOL Multiphysics software …

Reclaiming Tremé: A Design Research Thesis, Tori Dunston

Masters in Architecture Program: Theses

Reclaiming Tremé explores the potential for design to support the well-being of the oldest African American neighborhood divided by urban highway projects in the US. This comprehensive thesis that seeks to improve the well-being the neighborhood using precedents, historical context, and the quantifiable architectural goals of WELL v2, to present a design solution for Tremé. Through understanding the current communities needs and having historical context of the area, the design strategy focuses on creating a vibrant cultural core that enhances the community's well-being. By integrating new structures and amenities, preserving cultural heritage, and enhancing physical and social infrastructure, the project …

Comparative Research Of Rural Drinking Water Supply In Mongolia And Alaska, Batsuren Ganbat

Student Projects for Graduate Degrees

This comparative research project on rural drinking water supply in Mongolia and Alaska aimed to understand the challenges, dynamics, and best practices surrounding water access and utilities in rural communities within these regions. Through meticulous planning and execution, three cities in Mongolia and three cities in Alaska were selected as primary areas of study to capture the nuances and variations inherent in water supply dynamics across diverse geographical and socio-economic contexts. The objectives included investigating rural water supply systems, developing evidence-based recommendations, and fostering knowledge exchange and collaboration. A comprehensive literature review provided insights into existing scholarly works relevant to …

Perceived Barriers And Facilitators To Food Security In Ketchikan Alaska, Jessi Teune

Student Projects for Graduate Degrees

Ketchikan, Alaska is Alaska's First City and is famously known as the Salmon Capital of the world. Ketchikan is Lingít Aaní, the ancestral land of the Taantʼá Ḵwáan and Saanya Ḵwáan people of Revillagigedo Island.1 Ketchikan Gateway Borough is home to 13,754 residents.2 Being located on an island presents unique challenges to the residents regarding food security. Food that is not harvested or grown locally is shipped via barge from Seattle, WA. Limited published research exists regarding food security in Alaska, and primary research on food security in Ketchikan is nonexistent. The goal of this study is to analyze food …

A Cytoarchitectural Analysis Of The Rat Amygdala In Ultrathin Serial Sections, Katrina Schneider

Honors Scholar Theses

This study delves into the cellular composition and functional dynamics of the lateral amygdala (LA), a crucial brain region implicated in emotional and auditory processing/learning. Utilizing IHC, ultrathin serial sectioning (Ultraplex Method), and RNAscope, distinct cell types are characterized within the LA based on calcium-binding proteins (CBPs) and inhibitory markers such as GABA. Despite a modest sample size, a diverse array of cell types are identified, with calbindin-positive neurons prominently emerging in inhibitory cells. Notably, GABA intensity varies depending on cell identity and marker colocalization, hinting at complex regulatory mechanisms involving GABAergic signaling and CBPs. Analysis of vesicular glutamate transporter …

Characterization Of Platinum On Carbon Nanoparticles Selectively Coated With Titanium Nitride (Tin), Matthew Maramo

Honors Scholar Theses

Proton exchange membrane fuel cells are a promising low-carbon technology that still face problems including low durability during their normal operation cycles. At the cathode, the carbon supports of the catalysts may corrode. Atomic layer deposition of titanium nitride is performed on prepared catalyst layer samples. The purpose of the deposition is to create a thin film over the carbon supports to reduce carbon support corrosion and improve the lifespan of the fuel cell. Sheet resistances and contact angles are measured for the samples before and after the deposition, although some samples did not receive the deposition and post-deposition characterization …

Cpeb3 Maintains Developmental Competence Of The Oocyte, Lucie Lamacova, Denisa Jansova, Zongliang Jiang, Michal Dvoran, Daria Aleshkina, Rajan Iyyappan, Anna Jindrova, Heng Yu Fan, Yuxuan Jiao, Andrej Susor

Faculty Publications

Mammalian oocyte development depends on the temporally controlled translation of maternal transcripts, particularly in the coordination of meiotic and early embryonic development when transcription has ceased. The translation of mRNA is regulated by various RNA-binding proteins. We show that the absence of cytoplasmic polyadenylation element-binding protein 3 (CPEB3) negatively affects female reproductive fitness. CPEB3-depleted oocytes undergo meiosis normally but experience early embryonic arrest due to a disrupted transcriptome, leading to aberrant protein expression and the subsequent failure of embryonic transcription initiation. We found that CPEB3 stabilizes a subset of mRNAs with a significantly longer 3’UTR that is enriched in its …

Aerial, Surface, And Subsurface Multimodal Mapping In Coastal Peru: Insights From Cerro San Isidro, Moro Region, Nepeña Valley, Kayla Golay Lausanne, David Chicoine, Jeisen Navarro Vega, George F. Lau

Faculty Publications

This article describes a series of steps to integrate multiple modes of archaeological mapping in arid and agricultural settings. We use the coastal region of Peru as a case study and share our recent field experience at Cerro San Isidro, a multicomponent hill site located in the agriculture-intensive and mid-elevation (about 500 m asl) Moro region of the Nepeña Valley. In June and July 2022, we spent eight weeks deploying a combination of drone aerial imagery, pedestrian GPS reconnaissance, and GPR survey to map the surface and subsurface features at the site and in the adjacent agricultural fields. Our efforts …

Editorial Introduction: Exploring The Frontier Of Policy Theory Research, Geoboo Song, Melissa K. Merry, Saba Siddiki, Gwen Arnold, Aaron Smith-Walter, Holly L. Peterson, Creed Tumlison, Heasun Choi, Briana Huett, Davor Mondom, Christopher Giller, Meerim Seiitova

Faculty Publications

No abstract provided.

Effects Of Age And Gender On Perceptions On Victims Of Financial Exploitation, Kathleen Hillman

Honors Theses

A report by the Center for Victim Research shows that younger adults are more often victims of general and identity fraud (Irvin-Erickson & Ricks, 2019, p. 9); however, research conducted on financial exploitation focuses heavily on older adults. However, a recent study by Gunderson and colleagues (2021) found that older and younger adults are highly susceptible to financial exploitation. The purpose of the current study is to determine if perceptions of vulnerability to financial exploitation vary by the age of the victim. A sample of undergraduate participants will be recruited from the University of Tennessee at Chattanooga through an online …

Implications Of Learning Styles As A Tool On Universal Course Design, Laura Sacchetti

Instructional Design Publications

Creating an inclusive and accessible learning environment for all learners helps ensure the educational benefits can be enjoyed by the largest population possible. The theory of learning styles was developed as a response to the belief that learners respond better to educational stimulus that serves to their unique strengths. Learning styles cater to the strengths of each learner, whereas Universal Course Design accommodates all learners' needs. When used together, this symbiotic relationship can benefit learners in several ways. The implications of learning styles on Universal Course Design should be investigated to best determine its validity and usefulness in the classroom.

Screening Full-Sib And Half-Sib Families Of Chestnut Seedlings For Resistance To Cryphonectria Parasitica Using A Small Stem Assay And A Leaf-Disc Assay, Uma Plambeck

Honors Theses

Cryphonectria parasitica is the ascomycete fungus species that causes chestnut blight disease. Symptoms of chestnut blight include bark cankers and eventually the death of American chestnut, Castanea dentata. However, not all Castanea species are equally affected by the disease, and some Asian species appear highly resistant. The OALDS and SSA in this study aim to assist in screening for resistance to C. parasitica within a year. We investigated the effect of C. parasitica on three North American species, one European species, four East Asian species of Castanea, and nine full-sib families of TACF backcross hybrids. Our study used both a …

Transcendence In Kierkegaard And Barth, Andrew Myrick

Honors Theses

This paper examines the theological intersections and divergences between Karl Barth and Søren Kierkegaard, focusing on their conceptualizations of God's transcendence. Barth, influential in the twentieth century, viewed divine knowledge as accessible only through Jesus Christ's revelation, critiquing any historical or metaphysical bases for such knowledge. He was significantly influenced by Kierkegaard, who emphasized paradox and the "infinite qualitative distinction." This study traces Barth's evolving thoughts on transcendence across his works, including his critiques of Kierkegaard in his later years. While some scholars suggest a shared theological trajectory based on transcendence, this paper argues for nuanced differences, engaging with the …

Effects Of Attractiveness And Relationship Type Of Perceptions Of Adolescent Sexual Grooming, Alexandra Shappley

Honors Theses

Child sexual grooming is a prevalent issue within the United States, especially with the rise of the internet and social media (Shakeshaft, 2004; Finkelhor et al., 2000; Winters et al., 2017). There has been less research done on adolescent sexual grooming; however, researchers have found that perceptions of adolescent sexual grooming vary depending on the gender and age of the offender and victim (Russel & Gyrus, 2022; Sahl & Keene, 2012). Researchers have found that people perceive a sexual grooming relationship as inflicting more harm if the perpetrator is a man (Hernandez et al., 2019), particularly an older man (Russel …

The Competitive Advantage Of Prioritizing Human-Centered Design Thinking In Business, Joshua Rajan

Honors Theses

This thesis examines the impact of design thinking on promoting innovation within businesses. Design thinking is a human-centered problem-solving approach that solves problems using empathy, creativity, and iterative prototyping. The thesis commences by clearly defining design thinking and presenting its fundamental concepts, emphasizing how it differs from traditional business thinking. The thesis vividly illustrates the real-world impact of design thinking through compelling case studies from the consumer electronics, healthcare, automotive, and entertainment industries. It showcases how design thinking fosters creativity and develops solutions that prioritize customers' needs. The case studies show how companies gained a competitive advantage by deeply understanding …

Investigation Of Pra For Rapid Part Replacement, John Lazenby

Honors Theses

As the electronics industry transitions to using commercial-off-the-shelf (COTS) devices of increasingly smaller technologies, radiation effects analysis becomes more significant in mission planning. In this work a probabilistic risk assessment (PRA) program, RadSTATS, is used in the analysis of various COTS memories in a radiation environment. The probabilities that the bits in memory will be flipped due to single event upset (SEU) rates are calculated for each memory, volatile and non-volatile. The unavailability of bits was discovered to increase with increasing storage capacity. Methods of error detection and correction (EDAC) between the same manufacturer were seen to decrease at unavailability …

Recommendation System Using Machine Learning For Fertilizer Prediction, Durga Rajesh Bommireddy

Electronic Theses, Projects, and Dissertations

This project presents the development of a sophisticated machine-learning model aimed at enhancing agricultural productivity by predicting the optimal fertilizer suited to specific crop requirements. Leveraging a diverse set of features including soil color, pH levels, rainfall, temperature, and crop type, our model offers tailored recommendations to farmers. Three powerful algorithms, Support Vector Machines (SVM), Artificial Neural Networks (ANN), and XG-Boost, were implemented to facilitate the prediction process. Through comprehensive experimentation and evaluation, we assessed the performance of each algorithm in accurately predicting the best fertilizer for maximizing crop yield. The project not only contributes to the advancement of machine …

Fatty Acid Concentrations In Preterm Infants Fed The Exclusive Human Milk Diet: A Prospective Cohort Study, Lindsay F Holzapfel, Jana P Unger, Pam Gordon, Heeju Yang, Joanne E Cluette-Brown, Laura A Gollins, Amy B Hair, Camilia R Martin

Faculty, Staff and Student Publications

OBJECTIVE: Quantify blood fatty acids and growth outcomes in preterm infants fed the exclusive human milk diet.

METHODS: A prospective cohort study of 30 infants 24-34 weeks gestation and ≤1250 g fed the exclusive human milk diet. Blood fatty acids were quantified at two time points. Comparisons were made using two-sample t-tests and Wilcoxon rank sum.

RESULTS: Donor human milk-fed (n = 12) compared to mother's own milk-fed infants (n = 18) from birth to after 28 days of life, had an increased interval change of linoleic to docosahexaenoic acid ratio (5.5 vs. -1.1 mole percent ratio, p = 0.034). …

Imagined Intergroup Contact As A Mechanism To Change Beliefs About Gender, Samantha Oyler

Honors Theses

Gordon Allport first proposed the Intergroup Contact Theory in 1954. According to his theory, contact between ingroup and outgroup members, under certain conditions, would lead to positive effects, specifically the reduction of prejudice. Since then, this theory has been expanded to include members of other majority/minority groups. Research suggests intergroup contact has positive effects for reduction of anti-trans prejudice. To date, the focus has largely been on the mechanisms driving changes in attitudes and intentions towards trans individuals through intergroup contact interventions. It is unclear whether this intervention might also promote the acquisition of more nuanced sociocultural understanding about gender, …

Investigating Thin Filament Assembly In C. Elegans Muscles, Angela Russ

Honors Theses

All striated muscles are composed of small units called sarcomeres [1]. Within each sarcomere, there are thin filaments composed of actin and thick filaments composed of myosin. The thin filaments extend from either end of the thick filament towards the middle of the sarcomere. The lengths of thin filaments are correlated to muscle contraction and force production [1], but it is currently unknown what regulates their lengths. Prior hypotheses based on vertebrate models have focused on a nebulin ruler model [2]. However, nebulin is not present within invertebrate muscles, and this has led to a major gap in the field’s …

Civil Disobedience Of Social Workers In Hospice, Jamie Leigh Roper

Honors Theses

No abstract provided.

Association Of Maternal Body Mass Index And Maternal Morbidity And Mortality, Mara J Dinsmoor, Lynda G Ugwu, Jennifer L Bailit, Uma M Reddy, Ronald J Wapner, Michael W Varner, John M Thorp, Steve N Caritis, Mona Prasad, Alan T N Tita, George R Saade, Yoram Sorokin, Dwight J Rouse, Sean C Blackwell, Jorge E Tolosa

Faculty, Staff and Student Publications

Objective: This study aimed to assess the association of maternal body mass index (BMI) with a composite of severe maternal outcomes.

Study design: Secondary analysis of a cohort of deliveries on randomly selected days at 25 hospitals from 2008 to 2011. Data on comorbid conditions, intrapartum events, and postpartum course were collected. The reference group (REF, BMI: 18.5-29.9kg/m2), obese (OB; BMI: 30-39.9kg/m2), morbidly obese (MO; BMI: 40-49.9kg/m2), and super morbidly obese (SMO; BMI ≥ 50kg/m2) women were compared. The composite of severe maternal outcomes was defined as death, intensive care unit (ICU) admission, ventilator use, deep venous thrombosis/pulmonary embolus (DVT/PE), …

In Pursuit Of Water Justice In Jakarta, Widya Naseva Tuslian, Patricia Rinwigati, Stanislaus Sandyawan

The Indonesian Journal of Socio-Legal Studies

Despite becoming a rapidly growing megacity, in some of Jakarta’s areas, particularly in the underprivileged areas, a significant portion of its citizens still lack access to adequate domestic water. For years, water privatization has been considered a major barrier to solving the issue. Jakarta’s citizens have mobilized themselves to publicly reclaim Jakarta’s water governance. One of the significant actions was filing a citizen lawsuit against the relevant state authorities, which eventually was ruled in favor of the state authorities due to procedural reasons. Using the ROLAX framework developed by Bedner and Vel, this paper tries to understand to what extent …

Informing Control Efforts For A Prolific Invasive Species: Characterizing Common Carp Spatio-Temporal Distribution And Evaluating The Impacts Of Gear Selectivity In Utah Lake, Rae Fadlovich

All Graduate Theses and Dissertations, Fall 2023 to Present

Management programs that aim to reduce the consequences of invasive species are often challenged by populations that can rapidly recover from removal efforts. Selectivity, the relative impact of harvest on different size classes, can contribute to population recovery when younger fish are not effectively targeted. In Utah Lake, the location of one of the world’s largest freshwater fish control programs, managers have been attempting to control the common carp (Cyprinus carpio, hereafter “carp”) population since 2009 but efforts have been hindered by the use of selective fishing gears. I conducted a lake-wide field study to gain insights into …

Special Study: Vulnerability, Jacob Taylor

All Graduate Theses and Dissertations, Fall 2023 to Present

Special Study: Vulnerability is a collection of creative nonfiction essays engaged in recovering the stories of homeless individuals living in Salt Lake City, Utah. The recovery project is focused on the years 2017-2023, with special attention to the events of Operation Rio Grande (2017-2020). The essays seek to, among other things, provide a critique of public policy, increase public awareness of the issues facing the homeless population, and elicit empathy from readers.

Wellbeing, Mental Health, And Natural Resource Dependency In Rural Utah, Kristen Rene Koci

All Graduate Theses and Dissertations, Fall 2023 to Present

This dissertation examines wellbeing, mental health, and natural resource (NR) dependency in rural Utah. The following questions are asked: How do wellbeing and mental health vary throughout the state of Utah, including by rural-urban location? What concerns do applied practitioners have regarding mental health in rural parts of the state? How do chronic stress and social dislocation contribute to mental health outcomes in rural NR dependent communities in the state? Four studies were conducted to pursue these research questions.

The first two studies use data from the Utah Wellbeing Survey to explore wellbeing and mental health in Utah communities over …

Many Direct-To-Consumer Canine Genetic Tests Can Identify The Breed Of Purebred Dogs, Halie M. Rando, Kiley Graim, Greg Hampikian, Casey S. Greene

Computer Science: Faculty Publications

OBJECTIVE To compare pedigree documentation and genetic test results to evaluate whether user-provided photographs influence the breed ancestry predictions of direct-to-consumer (DTC) genetic tests for dogs.

ANIMALS 12 registered purebred pet dogs representing 12 different breeds. METHODS Each dog owner submitted 6 buccal swabs, 1 to each of 6 DTC genetic testing companies. Experimenters registered each sample per manufacturer instructions. For half of the dogs, the registration included a photograph of the DNA donor. For the other half of the dogs, photographs were swapped between dogs. DNA analysis and breed ancestry prediction were conducted by each company. The effect of …