Digital Commons Network^™

Management Of Diabetic Ketoacidosis In Children: Does Early Insulin Glargine Help Improve Outcomes?, Rebecca Ohman-Hanson, G Todd Alonso, Laura Pyle, Ryan Mcdonough, Mark A. Clements

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Rebound hyperglycemia following the resolution of diabetic ketoacidosis (DKA) is common in pediatric patients with type 1 diabetes, increasing the risk of recurrent DKA and complicating the transition to subcutaneous insulin. Multiple studies suggest that early administration of long-acting insulin analogs during DKA management safely improves this transition.

OBJECTIVE: This study aimed to determine whether early insulin glargine administration in children with DKA prevents rebound hyperglycemia and recurrent ketosis without increasing the rate of hypoglycemia or hypokalemia.

METHODS: Patients agedChildren's Mercy Kansas City between October 2012 and October 2016 were reviewed. They were categorized as Early (>4 h …

Using A Collaborative Learning Health System Approach To Improve Disease Activity Outcomes In Children With Juvenile Idiopathic Arthritis In The Pediatric Rheumatology Care And Outcomes Improvement Network., Julia G. Harris, Catherine A. Bingham, Sheetal S. Vora, Cagri Yildirim-Toruner, Michelle Batthish, Danielle R. Bullock, Jon M. Burnham, Danielle C. Fair, Kerry Ferraro, Suhas Ganguli, Mileka Gilbert, Beth S. Gottlieb, Olha Halyabar, Melissa M. Hazen, Ronald M. Laxer, Tzielan C. Lee, Alice Liu, Daniel J. Lovell, Melissa L. Mannion, Edward J. Oberle, Nancy Pan, Michael Shishov, Jennifer E. Weiss, Esi M. Morgan

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: The Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) is a North American learning health network focused on improving outcomes of children with juvenile idiopathic arthritis (JIA). JIA is a chronic autoimmune disease that can lead to morbidity related to persistent joint and ocular inflammation. PR-COIN has a shared patient registry that tracks twenty quality measures including ten outcome measures of which six are related to disease activity. The network's global aim, set in 2021, was to increase the percent of patients with oligoarticular or polyarticular JIA that had an inactive or low disease activity state from 76% to …

Evaluation Of The Alveolar Crest And Cemento-Enamel Junction In Periodontitis Using Object Detection On Periapical Radiographs, Tai Jung Lin, Yi Cheng Mao, Yuan Jin Lin, Chin Hao Liang, Yi Qing He, Yun Chen Hsu, Shih Lun Chen, Tsung Yi Chen, Chiung An Chen, Kuo Chen Li, Patricia Angela R. Abu

Ateneo Laboratory for Intelligent Visual Environments

The severity of periodontitis can be analyzed by calculating the loss of alveolar crest (ALC) level and the level of bone loss between the tooth’s bone and the cemento-enamel junction (CEJ). However, dentists need to manually mark symptoms on periapical radiographs (PAs) to assess bone loss, a process that is both time-consuming and prone to errors. This study proposes the following new method that contributes to the evaluation of disease and reduces errors. Firstly, innovative periodontitis image enhancement methods are employed to improve PA image quality. Subsequently, single teeth can be accurately extracted from PA images by object detection with …

Candida Auris Inpatient Screening In Collaboration With The Public Health Department., Christian Greco, Heather Smith, Brandy Gilbert, Jennifer Martin, Justin Smyer, Michael Haden, Christina Liscynesky, Shandra R Day, Nora Colburn

Ambulatory and Primary Care Articles

Candida auris is a multidrug-resistant fungal pathogen that is associated with nosocomial outbreaks in patients with extensive health care exposure and treatment outside the United States. The Ohio Department of Health recommends C auris screening in high-risk patients. However, this can be operationally difficult for many health care facilities. This report describes a C auris and carbapenem-resistant Enterobacterales inpatient screening program done in collaboration with state public health.

Enhanced Rate Capability And Capacity Of Lib Full Cells Achieved Through Aerosol Jet Printing, Rodrigo Rodriguez, L. Jay Deiner, Bang-Hung S. Tsao, Joseph P. Fellner

Publications and Research

Thick lithium-iron phosphate (LFP) cathodes (31 mg cm−2) with rationally engineered pore structure and tortuosity were manufactured with an aerosol jet (AJ) printer. Cathode pore structuring was tuned by controlling the rate at which the printed ink dried. Slow-drying prints yielded smoother cathodes while fast-drying prints resulted in mesoscale structuring with substantial surface roughness. X-ray tomography further revealed that the rapid drying of AJ printed LFP cathodes produced low-tortuosity pore channels which were preserved after calendering. Full cells comprised of AJ print optimized LFP cathodes, with 30 mg cm−2 active material loadings, and capacity-matched, AJ printed lithium titanate anodes were …

Untapped Potential? Understanding The Paraeducator-To-Teacher Pipeline And Its Potential For Diversifying The Teacher Workforce, Andrew M. Camp, Gema Zamarro, Josh B. Mcgee

Education Reform Faculty and Graduate Students Publications

Paraeducators are among the largest categories of public education employees and are increasingly seen as a pool of potential teachers. However, little is known about paraeducator-to-teacher transitions. Using statewide administrative data, we show that while paraeducators may be more racially/ethnically diverse than the teacher workforce, Black and Hispanic paraeducators are less likely than White paraeducators to transition into teaching. We additionally show that teachers with paraeducator experience are similarly effective to teachers without paraeducator experience. Lastly, we use simulations to show that the potential for the paraeducator-to-teacher pipeline to diversify the teaching profession may be limited unless they are highly …

Age-Related Dysregulation Of The Retinal Transcriptome In African Turquoise Killifish, Steven Bergmans, Nicole C L Noel, Luca Masin, Ellen G Harding, Aleksandra M Krzywańska, Julie D De Schutter, Rajagopal Ayana, Chi-Kuo Hu, Lut Arckens, Philip A Ruzycki, Ryan B Macdonald, Brian S Clark, Lieve Moons

2020-Current year OA Pubs

Age-related vision loss caused by retinal neurodegenerative pathologies is becoming more prevalent in our ageing society. To understand the physiological and molecular impact of ageing on retinal homeostasis, we used the short-lived African turquoise killifish, a model known to naturally develop central nervous system (CNS) ageing hallmarks and vision loss. Bulk and single-cell RNA-sequencing (scRNAseq) of three age groups (6-, 12-, and 18-week-old) identified transcriptional ageing fingerprints in the killifish retina, unveiling pathways also identified in the aged brain, including oxidative stress, gliosis, and inflammageing. These findings were comparable to observations in the ageing mouse retina. Additionally, transcriptional changes in …

The Smc5/6 Complex Prevents Genotoxicity Upon Apobec3a-Mediated Replication Stress, Dylan F Fingerman, David R O'Leary, Ava R Hansen, Thi Tran, Brooke R Harris, Rachel A Deweerd, Mithila Tennakoon, Alice Meroni, Jessica Devenport, Danielle Lavigne, Jeffrey Bednarski, Alessandro Vindigni, Abby M Green, Et Al.

2020-Current year OA Pubs

Mutational patterns caused by APOBEC3 cytidine deaminase activity are evident throughout human cancer genomes. In particular, the APOBEC3A family member is a potent genotoxin that causes substantial DNA damage in experimental systems and human tumors. However, the mechanisms that ensure genome stability in cells with active APOBEC3A are unknown. Through an unbiased genome-wide screen, we define the Structural Maintenance of Chromosomes 5/6 (SMC5/6) complex as essential for cell viability when APOBEC3A is active. We observe an absence of APOBEC3A mutagenesis in human tumors with SMC5/6 dysfunction, consistent with synthetic lethality. Cancer cells depleted of SMC5/6 incur substantial genome damage from …

Poly-Basic Peptides And Polymers As New Drug Candidates Against Plasmodium Falciparum, Roshan Sivakumar, Katherine Floyd, Jessey Erath, Alex Jacoby, Jenny Kim Kim, Peter O Bayguinov, James A J Fitzpatrick, Dennis Goldfarb, Marko Jovanovic, Abhai Tripathi, Sergej Djuranovic, Slavica Pavlovic-Djuranovic

2020-Current year OA Pubs

BACKGROUND: Plasmodium falciparum, the malaria-causing parasite, is a leading cause of infection-induced deaths worldwide. The preferred treatment approach is artemisinin-based combination therapy, which couples fast-acting artemisinin derivatives with longer-acting drugs, such as lumefantrine, mefloquine, and amodiaquine. However, the urgency for new treatments has risen due to the parasite's growing resistance to existing therapies. In this study, a common characteristic of the P. falciparum proteome-stretches of poly-lysine residues, such as those found in proteins related to adhesion and pathogenicity-is investigated for its potential to treat infected erythrocytes.

METHODS: This study utilizes in vitro culturing of intra-erythrocytic P. falciparum to assess the …

Covid-19 Safety: Perspectives From Dental Students, Man Hung, Daniel Yevseyevich, Amir Mohajeri, Nicole Hablitzel, Sharon Su, Martin S. Lipsky

Institute on Aging Publications

Background: The coronavirus (COVID-19) pandemic created challenges for healthcare providers, especially dental professionals in practices and universities. This study investigated dental students’ concerns about COVID-19 and whether institutional communication influenced pandemic-related stressors. Methods: An online survey designed to elicit dental students’ concerns about COVID-19 was distributed to all dental students enrolled at a private non-profit academic institution in the Western United States from 26 April 2021 to 25 August 2021. Descriptive statistics were used to characterize the respondents, and Chi-square test and z-test analyses were used to compare students’ experiences. Results: A total of 92 dental students answered the survey. …

Visible But Invisible: Chinese International Students’ Experience Of The Covid-19 Pandemic And Academic Institutions’ Support

Journal of Comparative & International Higher Education

No abstract provided.

Sequencing Internationalization Policy In The 21st Century: A Comparative Analysis Between Japan And The United States Of America

Journal of Comparative & International Higher Education

No abstract provided.

A Response To “The Danger Of Ideology”, Amie Thurber, Ericka Kimball

School of Social Work Faculty Publications and Presentations

On January 9, 2024, Social Work journal published in advance access a commentary by Farber and Fram titled “The Danger of Ideology: Social Work, Israel, and Anti-Semitism” (Farber & Fram, 2024). Writing following the October 7 Hamas attack on Israel, the authors lay out their central thesis in the opening paragraph: “We watch in horror and stand in support of Israel. As social work educators and scholars, we must also speak about the complicity of our profession in nurturing anti-Semitism and the ideology that undergirds Hamas and other terrorist organizations” (p. 1). This is a serious claim, and one that …

A Comprehensive Dataset For Arabic Word Sense Disambiguation, Sanaa Kaddoura, Reem Nassar

All Works

This data paper introduces a comprehensive dataset tailored for word sense disambiguation tasks, explicitly focusing on a hundred polysemous words frequently employed in Modern Standard Arabic. The dataset encompasses a diverse set of senses for each word, ranging from 3 to 8, resulting in 367 unique senses. Each word sense is accompanied by contextual sentences comprising ten sentence examples that feature the polysemous word in various contexts. The data collection resulted in a dataset of 3670 samples. Significantly, the dataset is in Arabic, which is known for its rich morphology, complex syntax, and extensive polysemy. The data was meticulously collected …

Optimised Path Planning Using Enhanced Firefly Algorithm For A Mobile Robot, Mohd Nadhir Ab Wahab, Amril Nazir, Ashraf Khalil, Benjamin Bhatt, Mohd Halim Mohd Noor, Muhammad Firdaus Akbar, Ahmad Sufril Azlan Mohamed

All Works

Path planning is a crucial element of mobile robotics applications, attracting considerable interest from academics. This paper presents a path-planning approach that utilises the Enhanced Firefly Algorithm (EFA), a new meta-heuristic technique. The Enhanced Firefly Algorithm (FA) differs from the ordinary FA by incorporating a linear reduction in the α parameter. This modification successfully resolves the constraints of the normal FA. The research involves experiments on three separate maps, using the regular FA and the suggested Enhanced FA in 20 different runs for each map. The evaluation criteria encompass the algorithms’ ability to move from the initial location to the …

Nonplanar Robotic Printing Of Earth-Based Material: A Case Study Using Cob-Like Mixture, Lina Ahmad, Wassim Jabi, Marco Sosa

All Works

The study presents an integration of cob with robotic processes. By challenging conventional monolithic earth-building methods, the study proposes the use of spatial nonplanar formations that are robotically fabricated, presenting an alternative geometric language for earth construction. The research methodology is derived from existing factors within the robotic lab, encompassing both constant and variable parameters. Through an experimental approach, the variables are systematically manipulated while observing the outcomes to identify patterns and relationships. Incremental refinements to the research conditions result in an optimal equilibrium state within the defined lab parameters. An empirical investigation approach serves as the foundation for controlling …

Value Of Macroalgae As Habitat In A Eutrophic Coastal Bay, Dominika Polchowska

Theses, Dissertations and Culminating Projects

Eutrophication is a phenomenon caused by changes in nutrient loading that results in harmful algal blooms, an overgrowth of macroalgae, altered aquatic benthic invertebrate communities, and loss of ecosystem functions. Barnegat Bay, NJ is a highly eutrophic system that has experienced a substantial loss of seagrass beds with subsequent expansion of drift macroalgae. Although considered poor quality, these algal beds represent valuable habitat for many benthic invertebrates. This research assesses the value of macroalgae as a habitat for macrofauna in regions where macroalgae are the dominant “vegetation.” Benthic drift algal samples were collected during June and August 2023 to reflect …

Cybersecurity In Education, Rahima Shelim

Theses, Dissertations and Culminating Projects

Cybersecurity is becoming increasingly important as we rely more on digital devices and programs to conduct our daily lives, including the transfer and storage of personal information. According to research, one of the most critical stages in improving cybersecurity is to implement an effective security awareness program. In this work, we seek to understand the existing level of security knowledge among college students, industry professionals and create a module to help raise the awareness. Our module's primary elements are interaction and the display of alarming effects of reckless cyber behaviors among common Internet/technology users. This report presents a simple systematic …

Transferred Benefits In Inter-Community Beach Nourishment: A Field Study On Efficiency, Owen Thomas

Theses, Dissertations and Culminating Projects

To combat the effects of relative sea level rise and the natural erosional processes affecting the sandy, diffusive beaches of New Jersey, most communities utilize beach nourishment to stabilize their beaches. Beach nourishment, the practice of artificially widening the beach berm with sand from other areas, not only stabilizes beaches but also protects oceanfront homes from storm surges, while adding recreational space and tourism value. These benefits are reflected in increased property values, most notably in oceanfront properties. The diffusive nature of these beaches, however, means that individual nourishment events are inherently shared with neighboring communities as sand is readily …

An Interdisciplinary Analysis Of Freshwater Wetlands With A Focus On Ecosystem Functions And Services, Michael Viteritto

Theses, Dissertations and Culminating Projects

Wetlands are one of the most productive ecosystems on Earth, though they only occupy a very small portion of the planet’s surface. They are highly sensitive ecosystems that have been undergoing an extended period of loss because of anthropogenic stress. Freshwater wetlands number among the most numerous on the planet, and in the United States they make up the overwhelming majority of wetland area. Geographically isolated wetlands (GIWs) are not directly connected to other surface water in a watershed. Freshwater wetlands provide a number of beneficial ecosystem services including climate control, erosion protection, nutrient removal and storage, flood control, food …

Onset Of Antarctic Glaciation At The Eocene-Oligocene Transition In The Weddell Sea And Its Impact On Ocean Circulation, Victoria Hojnacki

Theses, Dissertations and Culminating Projects

The Eocene – Oligocene Transition (EOT) (34 Ma) represents a greenhouse to icehouse climate transition that is marked by the appearance of permanent ice sheets in Antarctica. Studying this period of climate change allows us to understand how different Earth systems reacted under changing atmospheric CO₂ conditions. Though the timing of the development of the East Antarctic Ice Sheet is well supported, the development of the West Antarctic Ice Sheet is still up for debate. Ocean Drilling Program Site 696 is the only paleoarchive of the EOT in the Weddell Sea region and offers an opportunity to better constrain the …

Three Essays Examining Technology Adoption And The Role Of Physicians In Improving Efficiency, Quality And Reducing Risk In Healthcare Supply Chains, Rajib Dutta

Graduate Theses and Dissertations

Hospitals across the USA are operating under extreme financial stress and looking for opportunities to improve financial stability and maximize bottom-line savings. As supply chain function accounts for up to 40 percent of total hospital operating cost, hospital leaders are increasingly viewing the healthcare supply chain as a potential area for efficiency gain and cost reduction. The recipe for effective and efficient care delivery is to synchronize the flow of supplies with patient needs by integrating products, processes, and information while complying with government regulations. Therefore, proper management of inventory, role of government policies in shaping hospital strategies, adoption of …

High-Power Power Conditioning Systems For Medium-Voltage Applications, Ahmed Rahouma Fares Rahouma

Graduate Theses and Dissertations

The purpose of this dissertation is to address the background, theoretical analyses, design methodologies, and evaluation techniques relevant to high-power power conditioning systems (PCSs) tailored for medium-voltage (MV) applications. Conventional PCSs, reliant on line-frequency transformers (LFTs), suffer from many problems including low power densities, inflexible designs, and scalability constraints. Employing multilevel converters (MLCs), particularly cascaded H-bridge topology, eliminates the need for these LFTs. A key focus lies in minimizing the number of cascaded building blocks by harnessing MV power switching modules. The dissertation makes two primary contributions: firstly, it offers a design methodology for MV-PCS, facilitating the selection of the …

Investigating The Applications Of Peps To The Measurement Of The Stabilities Of Staphylococcal Nuclease (Stw) And Human Acidic Fibroblast Growth Factor (Hfgf1), Motolani Omolade Matthew

Graduate Theses and Dissertations

This dissertation presents a detailed investigation into the applications of Protein Equilibrium Population Snapshot H/D Exchange Electrospray Ionization Mass Spectrometry (PEPS-H/D exchange or PEPS) method. This method is based on protein equilibrium unfolding, and its fundamental capability is to capture a "snapshot" of the protein's state, allowing us to monitor the ratio of the unfolded to folded populations at different chemical denaturant concentrations. First, to increase the accuracy of PEPS data analysis for assessing protein stability, the traditional linear extrapolation method (LEM) was replaced. Instead of using LEM, which calculates free energy change based on the peak ratio of unfolded …

Partial Immunity To Mycoplasma Gallisepticum After An Initial Infection Is Long-Lasting And Reduces Transmission In Flocks Of Canaries, Madeline Sudnick

Graduate Theses and Dissertations

Pathology during a second infection can be influenced by immunity and an increase in resistance or tolerance of individuals. Population-level differences in the ability to maintain immunity can lead to contrasting survival outcomes between groups and determine how future outbreaks will spread. However, long term wildlife disease surveillance can be challenging due to lack of infrastructure and host-pathogen specific tests. Calculating disease transmission likelihood requires understanding individual-level heterogeneity in pathology and behavior, and there is limited knowledge in understanding how populations in different stages of an epidemic will transmit disease. In Chapter I, we aim to help fill a gap …

Parallel Degree Planning In The Pursuit Of Academic Success For Pre-Nursing Students In A Competitive Entry Baccalaureate Nursing Programs, Elizabeth L. Mckinley

Graduate Theses and Dissertations

This study sought to understand the student perceptions of parallel academic degree planning for the competitive entry undergraduate Nursing program at a case study university. Parallel degree planning is a relatively new term of alternative curricular planning. The qualitative study includes nine students and their experiences in planning for their intended major while simultaneously planning courses that meet another major or degree program, and understanding how parallel degree planning aided their retention and student satisfaction as well as their academic advisor interaction. The study was completed at a research university where the Nursing program has a very lower acceptance rate, …

Friendship Intimacy: A New Approach To Valuing Friendship, Benjamin Lugo

Graduate Theses and Dissertations

There is a tradition in moral theory that holds that friendship is necessary for living well. That is, if our aim is to live a good life or a flourishing life, then that life will include building and maintaining friendships. Aristotle and Plato both share this view and express similar claims about the necessity of friendship for the pursuer of a good life. Contemporaries of both have spent time interpreting their claims and have long commented on the intrinsic value of friendship. I pick up on a strand of the debate by exploring the purported value of friendship. While considerable …

Desire Lines: Reading Queerly Through The Forests Of Medieval Love Literature, Brianna Skye Oliver

Graduate Theses and Dissertations

This dissertation conducts queer eco-sensitive readings of a selection of medieval love texts in Middle English and Old French. Informed in turns by the works of feminist, queer, and ecocritical scholars, each chapter engages with a different iteration of literary queerness by bringing the representation of natural spaces and objects (especially the forest) to the fore and reading through nature depicted in the texts. The readings all share a broad goal of inviting modern audiences to play with desire and its manifestations within each text to make meaning and compel intimacy between the work and its current audience. Chapter 1 …

An Exploratory Multiple Case Study Of Special Education Transition Program Structures In Virtual Public Charter Schools, Krystle Merry

Graduate Theses and Dissertations

This dissertation research is an exploratory multiple-case study of special education transition program structures in three virtual public charter schools in a southern state in the United States. Virtual public charter schools are extensions of public school systems or districts that are required to comply with state and federal-mandated special education transition services to ensure students with disabilities receive a Free Appropriate Public Education (FAPE) under the Individuals with Disabilities Education Act (IDEA, 2004). This study aims to explore transition Program Structures within the Taxonomy for Transition Programming 2.0 (Kohler et al., 2016) at the systemic level based on the …

To Be Framed: Investigating The Influence Of American Media Frames On Gun Control, William C. Chamblee

Graduate Theses and Dissertations

Gun control may be one of the most polarizing political issues facing America today. While there are many factors that contribute to gun control controversy, one may be how it is framed by news organizations. Research suggests that the emergence of partisan news media, differing levels of issue salience, and the public’s increased willingness to selectively expose could widen the gap between both Republicans and Democrats through their opinions on the issue of gun control, causing polarization. Using a survey, this study found that both Republicans and Democrats are likely to selectively expose to partisan media outlets and that a …