Digital Commons Network^™

Heroin Or Fentanyl: Prevalence Of Confirmed Fentanyl In Ed Patients With Suspected Heroin Overdose, Siri Shastry, Evan Schwarz, Et Al.

2020-Current year OA Pubs

BACKGROUND: United States drug overdose deaths are being driven by the increasing prevalence of fentanyl, but whether patients are knowingly using fentanyl is unclear. We examined the analytical confirmation of fentanyl in emergency department (ED) patients with documented heroin overdose.

HYPOTHESIS: We hypothesized that the proportion of fentanyl and fentanyl analogs would be higher than that of confirmed heroin.

METHODS: This is a subgroup analysis from a prospective multicenter consecutive cohort of ED patients age 18+ with opioid overdose presenting to 10 US sites within the Toxicology Investigators Consortium from 2020 to 2021. Toxicology analysis was performed using liquid chromatography …

Accumulation Of Alkyl-Lysophosphatidylcholines In Niemann-Pick Disease Type C1, Sonali Mishra, Pamela Kell, David Scherrer, Dennis J Dietzen, Charles H Vite, Elizabeth Berry-Kravis, Cristin Davidson, Stephanie M Cologna, Forbes D Porter, Daniel S Ory, Xuntian Jiang

2020-Current year OA Pubs

Lysosomal function is impaired in Niemann-Pick disease type C1 (NPC1), a rare and inherited neurodegenerative disorder, resulting in late endosomal/lysosomal accumulation of unesterified cholesterol. The precise pathogenic mechanism of NPC1 remains incompletely understood. In this study, we employed metabolomics to uncover secondary accumulated substances in NPC1. Our findings unveiled a substantial elevation in the levels of three alkyl-lysophosphatidylcholine [alkyl-LPC, also known as lyso-platelet activating factor (PAF)] species in NPC1 compared to controls across various tissues, including brain tissue from individuals with NPC1, liver, spleen, cerebrum, cerebellum, and brain stem from NPC1 mice, as well as in both brain and liver …

Analytical Validation Of The Multitarget Stool Rna Test For Colorectal Cancer Screening, Erica K Barnell, Jack Land, Kimberly Kruse, Maya C Scott, Ben Wedeking, Catherine Morrison, Clayton Grass, Ann Zuniga, Elizabeth M Wurtzler, Eric J Duncavage

2020-Current year OA Pubs

The multitarget stool RNA (mt-sRNA) test (ColoSense) is a noninvasive diagnostic test that screens for colorectal cancer and advanced adenomas in average-risk individuals aged 45 years and older. The mt-sRNA test incorporates a commercially available fecal immunochemical test, concentration of eight RNA transcripts, and participant-reported smoking status. As part of the CRC-PREVENT (Colorectal Cancer and Pre-Cancerous Adenoma Non-Invasive Detection Test) clinical trial, 12 analytical validation studies were conducted to assess analytical sensitivity, linearity, precision, interfering substances, cross-reactivity, carry-over, cross-contamination, and robustness. Analytical validation of the mt-sRNA test demonstrated limit of blank, limit of detection, and limit of quantification of < 0.6, < 0.7, and ≤2.5 copies/μL for all markers, respectively. The mt-sRNA test demonstrated linearity between 2.5 and 2500 copies/μL, and < 20% coefficient of variation, and/or ≥95% concordance with regard to precision, interfering substances, carry-over, cross-contamination, and robustness. There was no significant impact of cross-reactivity from non-colorectal cancer diseases. These data provide a framework for laboratories to complete analytical validation for RNA-based panels that require premarket approval as a class III medical device from the US Food and Drug Administration.

Activated Sputum Eosinophils Associated With Exacerbations In Children On Mepolizumab, Gabriella E Wilson, Michelle Gill, Et Al.

2020-Current year OA Pubs

BACKGROUND: MUPPITS-2 was a randomized, placebo-controlled clinical trial that demonstrated mepolizumab (anti-IL-5) reduced exacerbations and blood and airway eosinophils in urban children with severe eosinophilic asthma. Despite this reduction in eosinophilia, exacerbation risk persisted in certain patients treated with mepolizumab. This raises the possibility that subpopulations of airway eosinophils exist that contribute to breakthrough exacerbations.

OBJECTIVE: We aimed to determine the effect of mepolizumab on airway eosinophils in childhood asthma.

METHODS: Sputum samples were obtained from 53 MUPPITS-2 participants. Airway eosinophils were characterized using mass cytometry and grouped into subpopulations using unsupervised clustering analyses of 38 surface and intracellular markers. …

Association Of Surgical Approaches And Outcomes In Total Mesorectal Excision And Margin Status For Rectal Cancer, Muhammad Bilal Mirza, Adriana C Gamboa, Rebecca Irlmeier, Benjamin Hopkins, Scott E Regenbogen, Katherine A Hrebinko, Jennifer Holder-Murray, Jason T Wiseman, Aslam Ejaz, Paul E Wise, Fei Ye, Kamran Idrees, Alexander T Hawkins, Glen C Balch, Aimal Khan

2020-Current year OA Pubs

INTRODUCTION: Despite being a key metric with a significant correlation with the outcomes of patients with rectal cancer, the optimal surgical approach for total mesorectal excision (TME) has not yet been identified. The aim of this study was to assess the association of the surgical approach on the quality of TME and surgical margins and to characterize the surgical and long-term oncologic outcomes in patients undergoing robotic, laparoscopic, and open TME for rectal cancer.

METHODS: Patients with primary, nonmetastatic rectal adenocarcinoma who underwent either lower anterior resection or abdominoperineal resection via robotic (Rob), laparoscopic (Lap), or open approaches were selected …

Youth Engagement In Religious Practices Within Macedonian Society, Ruzica Cacanoska, Ivan Blazevski Phd

Occasional Papers on Religion in Eastern Europe

Official statistical data and various research studies indicate that a significant portion of the Macedonian population identifies as religious. However, these studies also reveal that many of these individuals are nominal believers, adhering to traditional practices without deep engagement. This trend has sparked an interest in exploring the religiosity of the younger generation, which, though often superficial, has gained prominence in recent years. Existing research, albeit limited, has examined young people's religiosity, their perceptions of religion, and the influence of religious values on their daily lives and practices. To gain a comprehensive understanding of young people's attitudes towards religion in …

Enhancing Thermal Stability Of Perovskite Solar Cells Through Thermal Transition And Thin Film Crystallization Engineering Of Polymeric Hole Transport Layers, Sanggyun Kim, Sina Sabury, Carlo A. R. Perini, Tareq Hossain, Augustine O. Yusuf, Xiangyu Xiao, Ruipeng Li, Kenneth R. Graham, John R. Reynolds, Juan-Pablo Correa-Baena

Chemical and Materials Engineering Faculty Publications

Organic hole transport layers (HTLs) have been known to be susceptible to thermal stress, leading to poor long- term stability in perovskite solar cells (PSCs). We synthesized three 2,5-dialkoxy-substituted, 1,4-bis(2-thienyl)phenylene (TPT)-based conjugated polymers (CPs) linked with thiophene-based (thiophene (T) and thienothiophene (TT)) comonomers and evaluated them as HTLs in n-i-p PSCs. TPT-T (MB/C6), which has branched 2- methylbutyl and linear hexyl (MB/C6) side chains, emerged as a promising HTL candidate, enabling power conversion efficiencies (PCEs) greater than 15%. In addition, PSCs with this HTL showed an improvement in long-term stability at elevated temperatures of 65 °C when compared to those …

Shillinglaw, Susan, San Jose State University

Emeritus and Retired Faculty Biographies

University of North Carolina at Chapel Hill, English, 1985 Ph.D.

University of North Carolina at Chapel Hill, English, 1976 M.A.

Cornell College, English and Art, 1973 B.A.

Unveiling The Intercompartmental Signaling Axis: Mitochondrial To Er Stress Response (Mersr) And Its Impact On Proteostasis, Jeson Li

Dissertations and Theses (Open Access)

Maintaining protein homeostasis is essential for cellular health. During times of protein stress, cells deploy unique defense mechanisms to achieve resolution. Our previous research uncovered a cross-compartmental Mitochondrial to Cytosolic Stress Response (MCSR), a unique stress response activated by the perturbation of mitochondrial proteostasis, which ultimately results in the improvement of proteostasis in the cytosol. Here, we found that this signaling axis also influences the unfolded protein response of the endoplasmic reticulum (UPRER), suggesting the presence of a Mitochondria to ER Stress Response (MERSR). During MERSR, the IRE1 branch of UPRER is inhibited, introducing a previously unknown regulatory component of …

Navigating The Black Student First-Year Experience: Exploring Ways Peer Mentoring Can Enhance Engagement And Belonging At A Pwi, Richard V. Frazier Iii

Electronic Theses and Dissertations

Studies indicate that minoritized students attending Predominantly White Institutions (PWI) may struggle with engagement and establishing a sense of belonging. Peer mentoring may play a role in enhancing these opportunities to foster academic performance and retention. The sense of belonging and engagement for minoritized students at a PWI is essential to their academic sustainability. This qualitative narrative analysis study uses Strayhorn’s (2012) theory of college students’ sense of belonging as the theoretical framework to explore the peer mentoring experiences of 10 Black first-year students participating in a stand-alone model. Interviews were used to acquire insight into peer mentoring’s influence on …

A Neural Network Approach To Predict Opioid Misuse Among Previously Hospitalized Patients Using Electronic Health Records, Lucas Vega, Winslow Conneen, Michael A. Veronin, Robert P. Schumaker

Computer Science Faculty Publications and Presentations

Can Electronic Health Records (EHR) predict opioid misuse in general patient populations? This research trained three back propagation neural networks to explore EHR predictors using existing patient data. Model 1 used patient diagnosis codes and was 75.5% accurate. Model 2 used patient prescriptions and was 64.9% accurate. Model 3 used both patient diagnosis codes and patient prescriptions and was 74.5% accurate. This suggests patient diagnosis codes are best able to predict opioid misuse. Opioid misusers have higher rates of drug abuse/mental health disorders than the general population, which could explain the performance of diagnosis predictors. In additional testing, Model 1 …

Exploring Intraplate Seismicity In The Midwest, Alexa Fernández

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

Intraplate seismicity represents a notable occurrence within the stable North American Craton. This research explores the potential sources of stresses that could reactivate older faults and influence seismic activity within this region. Among these sources, the enduring impact of the last glacial period is considered, which includes continued glacial isostatic adjustments (GIA). During GIA the lithosphere rebounds due to the retreating ice, and the forebulge caused by far-field flexure in response to the glacial load, collapses. This results in significant faulting, fracturing, and seismic activity associated with the deglaciation phase. The adjustment of the lithosphere manifests as both near surface …

Transforming Grassland Conservation: Challenges And Opportunities Across Law, Policy, And Human Dimensions, Conor D. Barnes

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Great Plains social-ecological systems are facing growing pressure from complex, ‘wicked’ problems. Addressing these problems will require integrating ecological resilience and complex systems thinking concepts into our legal framework in order to better reflect the changing ecological reality of the Great Plains and promote flexibility and adaptability in the face of that change. In this dissertation, I examine how past and present policy priorities have affected social-ecological systems on the Great Plains, and how ecological resilience and complex systems thinking might be applied to grassland management policy. In Chapter 2, I examine the rapid progress made in the adoption of …

"I Will Write Mad Stories": The Hysterical "I" In The Diaries Of George Eliot, Charlotte Forten Grimke, Virginia Woolf, And Sylvia Plath, Jaclyn Marie Swiderski

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation focuses on the long history of hysteria and the ways in which it has been used to denigrate and silence disabled women. Women diagnosed as hysterical, by either the medical establishment or the court of public opinion, are denied the right to generate knowledge about and for themselves – they are epistemologically disabled. The author argues that hysterical women have unique ways of looking at and understanding the world which push back against their epistemological disablement. In order to uncover some of this history of hysterical women, this dissertation uses the diaries of four “hysterical” women over the …

Role Of The Malate Dehydrogenase-Citrate Synthase Metabolon In Metabolic Flux Regulation, Joy John Omini

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The TCA cycle enzymes- malate dehydrogenase (MDH) and citrate synthase (CS)- interact to transfer oxaloacetate from the active site of MDH to the active site of CS, through an electropositive channel. The MDH-CS metabolon is highly conserved across different domains of life, and it has been associated with many advantages. Some of these advantages include protecting oxaloacetate from competing enzymes like aspartate aminotransferase, allowing the thermodynamically unfavorable MDH forward reaction to occur and increasing the local concentration of oxaloacetate within the active site of CS. These advantages and conservativeness of the MDH-CS metabolon indicate that it is highly important to …

Laser Surface Processing For Enhanced Adhesion Between Diamond Coatings And Metallic Substrates, Zhipeng Wu

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Application of diamond coatings on metallic substrates endows them with superior properties including mechanical robustness and corrosion resistance, rendering them highly adaptable for diverse industrial and technological applications. However, significant disparities in coefficients of thermal expansion (CTEs) result in pronounced residual stress near interfaces, causing delamination of the diamond coatings. Moreover, weak chemical bonding poses a concern for certain metallic substrates. Laser surface processing techniques show promise in enhancing adhesion by altering stress distribution and improving mechanical bonding. Therefore, the research efforts described in this dissertation mainly focus on femtosecond (fs) laser texturing for enhanced adhesion of diamond coatings on …

Dynamics Of Soybean Seed Protein And Oil Content With Depth In The Canopy, Hafith Furqoni

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Understanding the physiological basis of variation in seed composition is critical for optimizing soybean seed composition. Also, studying dry matter accumulation and nitrogen uptake, partitioning, and redistribution in soybeans is crucial due to its direct impact on seed yield levels and overall plant productivity. This study aimed to test the primary proxy influencing seed protein and oil content, which is their accumulation rate determined by the assimilate supply per seed. The second objective was to comprehensively understand soybean dry matter (DM) accumulation and nitrogen (N) uptake, partitioning, and removal patterns within the canopy. Field experiments were conducted using two soybean …

Remotely Sensed Early Warning Of Algal Blooms In An Eastern Nebraska Reservoir: A Comparison Of Temporal And Spatial Indicators, Mercy Kipenda

School of Natural Resources: Dissertations, Theses, and Student Research

Cyanobacterial harmful algal blooms (CyanoHABs) detrimentally affect human, animal, and ecosystem health. Remotely sensed early warning systems for cyanoHABs in inland lakes could contribute to more proactive water quality monitoring and help mitigate negative impacts. Advances in freely available remote sensing imagery, with finer spatial, temporal, and spectral resolutions, present new opportunities for the development and comparative analysis of methods to detect sudden deterioration in lake water quality. In this thesis, I compared and tested for temporal and spatial early warning signals of cyanoHABs in field-based and remotely sensed datasets from 2019 to 2023 in Pawnee Lake in southeast Nebraska, …

Impacts Of Invasive Carp And Their Population Dynamics On Fish Communities In The Missouri River, Joshua F. Kocik

School of Natural Resources: Dissertations, Theses, and Student Research

Invasive Carp species: Silver Carp Hypophthalmichthys molitrix, Bighead Carp Hypophthalmichthys nobilis, Grass Carp Ctenopharyngodon idella, and Black Carp Mylopharyngodon piceus have both potential and realized abilities to negatively impact native species. Specifically, Bighead Carp and Silver Carp as filter feeders have been theorized to be detrimental not only to adult filter-feeding species, but to many fish which rely on plankton and algae in their early-life stages. The impact of Invasive Carp on the overall fish community remains underexplored. The fish communities below Gavins Point Dam (Invasive Carp present) and Fort Randall Dam (Invasive Carp absent) afford the …

Spatiotemporal Plasticity In Reproductive Readiness And Recruitment Of Ichthyoplankton Of Invasive Silver Carp Along A Western Invasion Front, Jessi L. Urichich

School of Natural Resources: Dissertations, Theses, and Student Research

Individuals of invasive species at the edge of their invasion distribution may exhibit enhanced reproductive capacity and phenotypic plasticity leading to accelerated range expansion. Environmental conditions in highly fluctuating environments at distribution edges may either promote or hinder such reproductive readiness and phenotypic plasticity. Dynamic habitat conditions and periodic disturbances experienced in prairie streams, such as drought (e.g., low-flow, high water temperatures), may potentially reduce suitable spawning environments and ichthyoplankton recruitment of invasive Silver Carp, potentially slowing range expansion or enabling management strategies that reduce abundance in the absence of a reproducing population. Female Silver Carp batch fecundity, Gonadosomatic Index …

Child And Caregiver’ Perspective On Barriers To Asthma Management At A Tertiary Referral Hospital In Kenya, Joan Kwesigabo Ahimbisibwe

Master of Medicine in Paediatrics and Child Health

Background: Asthma is one of the most common chronic conditions in children, with significant morbidity and mortality, especially in Africa. Achieving adequate asthma control in children remains challenging due to gaps between standard recommended management strategies and treatment practices. This study explored barriers to asthma management as perceived by children and their caregivers in a private tertiary care setting in Kenya.

Methods: An exploratory phenomenological qualitative study was conducted at Aga Khan University Hospital (AKUH), Nairobi. Children aged 6–18 years with a confirmed diagnosis of asthma and their caregivers were recruited. Participants had been receiving treatment for at …

The Nature Of X-Rays From Young Stellar Objects In The Orion Nebula Cluster—A Chandra Hetgs Legacy Project, Norbert S. Schulz, David P. Huenemoerder, David A. Principe, Marc Gagné, Hans Mortiz Günther, Joel Kastner, Joy Nichols, Andrew Pollock, Thomas Preibisch, Paola Testa, Fabio Reale, Fabio Favata, Claude R. Canizares

Earth & Space Sciences Faculty Publications

The Orion Nebula Cluster (ONC) is the closest site of very young (∼1 Myr) massive star formation The ONC hosts more than 1600 young and X-ray bright stars with masses ranging from ∼0.1–35 Me. The Chandra HETGS Orion Legacy Project observed the ONC with the Chandra High Energy Transmission Grating Spectrometer (HETGS) for 2.1 Ms. We describe the spectral extraction and cleaning processes necessary to separate overlapping spectra. We obtained 36 high-resolution spectra, which include a high-brilliance X-ray spectrum of θ1 Ori C with over 100 highly significant X-ray lines. The lines show Doppler broadening between 300 and 400 km …

Competing In Innovation-Intensive Environments: The Role Of Soft Power, Learning, And Ceo Heuristics, Cristina O. Vlas, Bruno Barreto De Góes, Radu E. Vlas, Eugene See

Management and Decision Sciences

We start by exploring how the interplay of soft power and learning levers helps firms address competitive uncertainty in innovation-intensive environments (IIEs). We then theorize that firms’ motivation to pursue a specific combination of soft power and learning tactics in IIEs is shaped by CEO regulatory focus. The analysis of a panel of IIE firms supports our theorizing and reveals that accounting for CEO regulatory focus is elemental to the understanding of firms’ performance heterogeneity in such environments. We conclude that a perspective focused on a combination of soft power and learning tactics is better fitted to explain firms’ performance …

Theoretical Justifications For Trade Secrets Protection Of Routine Business Information, Timothy Murphy

Buffalo Law Review

For over a century trade secret law has protected internal business information from misappropriation by departing employees. Over this time, courts developed various limiting doctrines to minimize the impact of this broad protection on employee mobility in particular cases. However, the workplace has changed significantly over this time and these changes raise substantial questions as to whether there is any valid theoretical justification for continuing to protect routine business information under trade secret law. In an environment where the vast majority of trade secrets claims are against former employees, the lack of sound justification for protecting routine business information, the …

A Quality Improvement Project On The Evaluation Of A Community Gastroenterology Advanced Practice Providers’ Update On The Utilization Of The American College Of Gastroenterology (Acg) Recommendation For Annual Depression Screening In Patients With Inflammatory Bowel Disease, Yolanda Levy Dnp, Fnp-Bc

All Dissertations

Inflammatory bowel disease (IBD) is an autoimmune disease that can result in chronic inflammation in the gastrointestinal tract (Farbod et al., 2021). The two most common types of IBD are called Crohn’s disease and Ulcerative Colitis. There have been several studies that have shown how the psychological disorders, including depression, can be associated with flares of IBD (Farraye et al., 2017). The American College of Gastroenterology (ACG) published clinical practice guidelines in 2017, which recommended gastroenterology (GI) healthcare providers screen for depression in all patients with IBD at least once annually (Farraye et al., 2017). This quality improvement did show …

Cover Page And Editorial Board, Buffalo Law Review

Buffalo Law Review

No abstract provided.

University Of South Carolina Libraries Collection Development Policy, University Of South Carolina Libraries

University Libraries Policies and Reports

University Libraries supports the mission and vision of the University of South Carolina by building and managing general collections that support student success and research excellence. In developing its general collections, University Libraries strives to respond to current and anticipated teaching and research needs, to provide the broadest possible access to library resources, and to responsibly steward materials of enduring academic value.

A Generalization Of The Graham-Pollak Tree Theorem To Even-Order Steiner Distance, Joshua N. Cooper, Gabrielle Tauscheck

Faculty Publications

Graham and Pollak showed in 1971 that the determinant of a tree’s distance matrix depends only on its number of vertices, and, in particular, it is always nonzero. The Steiner distance of a collection of 𝑘 vertices in a graph is the fewest number of edges in any connected subgraph containing those vertices; for 𝑘 =2 , this reduces to the ordinary definition of graphical distance. Here we show that the hyperdeterminant of the 𝑘 th order Steiner distance hypermatrix is always nonzero if 𝑘 is even, extending their result beyond 𝑘 =2 . Previously, the authors showed that the …

Effects Of The Russia-Ukraine Conflict On The Internationalization Of Higher Education In Kyrgyzstan, Martha Merrill

Journal of Comparative & International Higher Education

No abstract provided.

Child Privacy In The Digital Era: Is Coppa Enough?, Melannie Sandoval

Joint PIJIP/TLS Research Paper Series

Children growing up in the digital age are experiencing an entirely different world than their parents once did. While most adults’ first online experience occurred on a bulky desktop computer, today’s children are born into a society that is largely digitized and where online accessibility is at the swipe of a pocket-sized smartphone. Despite the many benefits that this generation of children enjoys due to the increased access to the internet and innovative technology, parents, child advocates, and privacy experts caution against the dangers that arise when children enter the digital landscape.

Part I of this paper delves into children’s …