Digital Commons Network^™

Assessing Healthcare Interventions: Impact Of Covid-19 Precautions On Hospital Acquired Infections, Judeil Krlan Teus, Lucinda Mithen, Heidi Green, Alison Hutton, Ritin Fernandez

International Nursing Research Congress (INRC)

Personal protective equipment (PPE) has played a fundamental role in protecting healthcare workers and patients, but its effectiveness in reducing hospital-acquired infections (HAIs) during the pandemic remains a subject of debate. This systematic review and meta-analysis explores the impact of COVID-19 precautions on HAIs and its implications for future practice.

Preceptor Toolkit Effects On New Graduate Nurse Orientation Experience, Ashley Dunnier

MSN Capstone Projects

The role of the nurse preceptor is vital to the successful onboarding of new graduate nurses to the organization. By focusing on preceptor support methods in addition to the established nursing preceptor programs, organizations can improve the nurse preceptor’s confidence and competency levels. The opportunities for improvement, solution recommendation, timeline, and associated costs are provided in this summary.

Many organizations have seen an increase in new graduate nurses leaving their jobs within their first year of hire. The transition period of new graduate nurses is often a period of transition shock while they acclimate into professional practice from academia (Fink …

Improving Palliative Care Knowledge In The Acute Care Setting, Laura C. Brumett

MSN Capstone Projects

Aim: The aim of this paper is to present an education intervention for bedside nursing staff to improve their palliative care knowledge and the end-of-life care provided for terminally ill patients.

Background: When dying in the hospital, patients experience higher discomfort, lower quality of life, and prolonged family grieving. Suffering worsens when patient needs are unmet and can contribute to a traumatic death. Providing end-of-life education will increase a nurse’s knowledge of palliative care, address knowledge gaps, and promote better patient outcomes through improved clinical practice.

Design: The proposed intervention has three prongs which include: (1) virtual training using the …

Recurrent Inflammatory Myofibroblastic Tumor Of Larynx Harboring A Novel Thbs1::Alk Fusion, Namra Ajmal, Stacey Gargano, Ujwala Gosavi, Madalina Tuluc

Computational Medicine Center Faculty Papers

Inflammatory myofibroblastic tumor (IMT) is a rare soft tissue tumor primarily occurring in the abdominopelvic region of young patients, and it is characterized by spindle-shaped myofibroblasts, or fibroblasts surrounded by inflammatory infiltrate. Herein, we report a case of a 24-year-old male with a firm submucosal mass in the anterior right vocal fold diagnosed as an IMT that recurred 14 months later. The tumor demonstrated a novel THBS1::ALK fusion containing Exons 1-7 of the thrombospondin 1 (THBS1) gene fused to Exon 19 of the anaplastic lymphoma kinase (ALK) gene via next-generation sequencing with the NextSeq sequencer. The fusion of THBS1 to …

Augmenting Social Engagement For Students: Leveraging Ar For Interactive Student Experiences, Promoting Overall Well Being., Aditi Singh

Theses

This thesis explores the concept of an Augmented Reality Application designed to enhance student’s social engagement with their peers in campus activities at universities. It uses AR Technology and futuristic interface design to create a fun and interactive environment that motivates graduate students to socialize more often and maintain a balanced lifestyle. The problem addressed here is the lack of motivation and resources among students to engage in activities due to academic pressures which also adversely affects students mental and emotional wellbeing. The proposed solution involves integrating AR interfaces and elements that immerse them in an enjoyable environment and encourage …

2024 Fall Convocation Program, Morehead State University. Office Of Communications & Marketing.

Communications and Marketing Publications Archive

The 2024 Morehead State University Convocation Program from August 14, 2024.

Feasibility Study Of Mim Auto-Contouring For Head And Neck Patients That Have Dental Artifact Using A Metal Artifact Reduction Scan, Allison C. Munyer

Masters Projects

Introduction

Accurate contouring of organs at risk (OARs) is essential in the treatment of head and neck cancer, particularly in patients with metal dental artifacts that can obscure critical structures. The ability to precisely define these OARs is crucial for minimizing radiation exposure to healthy tissues and improving patient outcomes. To address the challenges posed by metal artifacts, Metal Artifact Reduction (MAR) technology, including iterative MAR (IMAR) scanning, has been widely adopted in radiation oncology.

Methods

This retrospective study evaluated the impact of IMAR scanning and Medical Image Merge (MIM) auto-contouring software on the accuracy and efficiency of contouring OARs …

We Are The Ai Problem, Tonja Jacobi, Matthew Sag

Emory Law Journal Online

This Essay describes what we call “the Black Nazi Problem,” a shorthand for the sometimes-jarring text and images produced by AI, from the incongruous—such as female Indian popes—to the outrageous—such as depicting minorities as their own historical oppressors, including Black Nazis. These images were the result of overzealous efforts by AI developers to correct for a lack of diverse representation in the training data used to create Generative AI models. The overrepresentation of white, fully-abled, Western men in images of high status categories, and the invisibility of women, people of color, and the disabled, except in low status categories, and …

Development Of A Novel Amplifiable System To Quantify Hydrogen Peroxide In Living Cells, Xiqian Jiang, Jianwei Chen, Sandipan Roy Chowdhury, Ninghui Cheng, Paul A Nakata, David M Lonard, Meng C Wang, Jin Wang

Faculty, Staff and Students Publications

Although many redox signaling molecules are present at low concentrations, typically ranging from micromolar to sub-micromolar levels, they often play essential roles in a wide range of biological pathways and disease mechanisms. However, accurately measuring low abundant analytes has been a significant challenge due to the lack of sensitivity and quantitative capability of existing measurement methods. In this study, we introduced a novel chemically induced amplifiable system for quantifying low-abundance redox signaling molecules in living cells. We utilized H2O2 as a proof-of-concept analyte and developed a probe that quantifies cellular peroxide levels by combining the NanoBiT system with androgen receptor …

Clinical And Radiographic Outcomes After Mechanical Thrombectomy In Medium-Vessel Posterior Cerebral Artery Occlusions: Subgroup Analysis From Star, Pascal Jabbour, Joon-Tae Kim, Stacey Quintero Wolfe, Ansaar Rai, Robert M Starke, Marios-Nikos Psychogios, Amir Shaban, Nitin Goyal, Shinichi Yoshimura, Hugo Cuellar, Brian Howard, Ali Alawieh, Ali Alaraj, Mohamad Ezzeldin, Daniele G Romano, Omar Tanweer, Justin Mascitelli, Isabel Fragata, Adam Polifka, Fazeel Siddiqui, Joshua Osbun, Roberto Crosa, Charles Matouk, Min S Park, Michael R Levitt, Waleed Brinjikji, Mark Moss, Ergun Daglioglu, Richard Williamson, Pedro Navia, Peter Kan, Reade De Leacy, Shakeel Chowdhry, David J Altschul, Alejandro Spiotta, Ramesh Grandhi

Faculty, Staff and Students Publications

BACKGROUND: Whereas mechanical thrombectomy (MT) has become standard-of-care treatment for patients with salvageable brain tissue after acute stroke caused by large-vessel occlusions, the results of MT in patients with medium-vessel occlusions (MEVOs), particularly in the posterior cerebral artery (PCA), are not well known.

METHODS: Using data from the international Stroke Thrombectomy and Aneurysm Registry (STAR), we assessed presenting characteristics and clinical outcomes for patients who underwent MT for primary occlusions in the P2 PCA segment. As a subanalysis, we compared the PCA MeVO outcomes with STAR's anterior circulation MeVO outcomes, namely middle cerebral artery (MCA) M2 and M3 segments.

RESULTS: …

Hyperpolarized Magnetic Resonance Imaging, Nuclear Magnetic Resonance Metabolomics, And Artificial Intelligence To Interrogate The Metabolic Evolution Of Glioblastoma, Xiaoqian Jiang, Pratip K Bhattacharya, Shyan Shams

Faculty, Staff and Student Publications

Glioblastoma (GBM) is a malignant Grade VI cancer type with a median survival duration of only 8-16 months. Earlier detection of GBM could enable more effective treatment. Hyperpolarized magnetic resonance spectroscopy (HPMRS) could detect GBM earlier than conventional anatomical MRI in glioblastoma murine models. We further investigated whether artificial intelligence (A.I.) could detect GBM earlier than HPMRS. We developed a deep learning model that combines multiple modalities of cancer data to predict tumor progression, assess treatment effects, and to reconstruct in vivo metabolomic information from ex vivo data. Our model can detect GBM progression two weeks earlier than conventional MRIs …

Prekindergarten Teacher Experiences With Professional Development For Inclusive Practices, Clory D. Walker

Walden Dissertations and Doctoral Studies

Teachers in inclusive prekindergarten (PK) settings often serve children with special learning needs without having had professional preparation or development (PD) for using inclusive practices. The problem addressed in this basic qualitative study was that many PK teachers have not received the PD they needed to promote inclusive practices to teach young children within inclusive early childhood classrooms. The purpose of this basic qualitative study was to explore PK teachers’ perspectives on the PD they need to promote inclusive practices to teach all young children, including children with special learning needs, in inclusive early childhood classrooms. The conceptual framework used …

Parental Experiences And Health Education Perceptions Raising Children With Orofacial Clefts, Ama Agyeibea Amuasi

Walden Dissertations and Doctoral Studies

Congenital abnormalities, such as cleft lip and/or palate (CL/P), are a significant global public health issue that contribute to newborn morbidity and mortality, difficulties in social integration, psychological problems for affected persons, parents, and families. Available health education information and resources on CL/P care for parents and families in Ghana are however minimal. The purpose of this qualitative study was to explore the health education perceptions of parents of children born with CL/P to identify and understand experiences of common psychosocial challenges, potential risk, and protective factors used by parents. Five research questions were designed to examine the health education …

Successful Strategies Of Small Business Owners Of Coffee Shops, Tom Gates

Walden Dissertations and Doctoral Studies

Many small business owners of U.S. coffee shops lack effective strategies to sustain their business beyond the first 5 years. Small business owners are concerned that the use of ineffective strategies can negatively impact the coffee shop’s profitability and competitiveness. The purpose of the qualitative multiple case study was to explore what type of skills, business acumen, and strategies small business owners of coffee shops use to be successful within the first 5 years of operation. The conceptual framework that grounded this study was von Bertalanffy’s general systems theory. The participants were five small business coffee shop owners in the …

Strategies To Address The Healthcare Staffing Crisis In An Acute Care Hospital, Allison L. Windas

Walden Dissertations and Doctoral Studies

Healthcare staffing shortages are widespread and challenging; developing a successful retention and recruitment strategy requires an awareness of the generational, cultural, and environmental elements that positively influence employee motivation and engagement. The purpose of this integrative review was to synthesize existing research on factors that enhance hospital staff work satisfaction and increase intent to stay. Using the Job Characteristics Theory as a framework, an integrative review of literature published between 2019 and 2024 synthesized existing research on factors that enhance hospital staff work satisfaction and increase intent to stay. Thematic analysis of 35 selected studies identified four key themes and …

Cover And Contents

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

Production, Purification, And Specificity Serologically Determination Of Immunoglobulin-Y (Igy) From Chicken Eggs Against Clostridium Tetani Toxoid, Kürşat Teti̇k, Bariş Sareyyüpoğlu

Turkish Journal of Veterinary & Animal Sciences

Tetanus is a life-threatening bacterial disease of humans and many animal species caused by the neurotoxin tetanospasmin (TeNT) produced by Clostridium tetani. Antitoxins obtained from horses and humans are primarily used to treat this disease. However, there are several clinical side effects and disadvantages associated with the use of these antitoxins. Current techniques for diagnosing tetanus use monoclonal antibodies produced in mice. These antibodies have several advantages, such as homogeneity and specificity. In contrast, a notable feature of polyclonal antibodies, especially egg yolk antibodies (IgYs) extracted from poultry, is that they can be generated in greater quantities than mammalian antibodies …

Adaptation And Evaluation Of Guideline-Based Family-Based Behavioral Treatment For Overweight And Obesity In Childhood Survivors Of Acute Lymphoblastic Leukemia And Lymphoma, Jessica Jakubiak

Arts & Sciences Graduate Student Theses and Dissertations

Children who survive acute lymphoblastic leukemia (ALL) and lymphoma are at considerable risk for chronic, treatment-related medical complications known as “late effects.” Not only are these late effects significant in and of themselves, but many are exacerbated by excess weight, a particularly concerning combination given the elevated rates of overweight and obesity within this population. Although the therapeutic regimens (e.g., steroid “pulses”) endured by children who survive ALL and lymphoma may contribute to excess weight, accumulating evidence also demonstrates the development of poor dietary habits and inadequate levels of physical activity during cancer treatment. Such weight-related health behaviors appear to …

Synthesis Of Addressable Libraries: New Lessons And The Need For Proper Characterization For Microelectrode Array-Based Reactions, Albert Huang

Arts & Sciences Graduate Student Theses and Dissertations

The Moeller group has been developing synthetic tools for building molecular libraries on microelectrode arrays since 2004. Such a library is intriguing because one can take advantage of the library for biological signaling studies. Microelectrode arrays can serve as a powerful platform for those experiments since every electrode in the array can be addressed individually. Unique members of the library targeting biological receptors that one is interested in can be restricted only above unique electrodes in an array. Thus, high-affinity ligands for those receptors can be identified with this strategy. To make this method work, one has to make sure …

Insights From Open Conformations Of Ecmsck, Htrpv4, And Hhcn1 Into The Structural Basis Of Ligand-Regulated Ion Channel Gating, Jonathan Mount

Arts & Sciences Graduate Student Theses and Dissertations

Ion channels are found in all domains of life and play fundamental roles in cellular signaling and response to environmental cues. The ability to accommodate the selective and rapid passage of ions across a cell membrane is conferrable by a myriad of protein folds with no singular one-size-fits-all approach. With the advent of the cryo-EM resolution revolution, substantial interest has developed for determining the molecular structures of conformational states that correspond to conductive and nonconductive forms of ion channels. By gaining insight into the structural mechanisms for ion channel gating, we can potentially reveal binding pockets for targeted small molecule …

Persistence Of Daptomycin-Resistant And Vancomycin-Resistant Enterococci In Hospitalized Patients With Underlying Malignancies: A 7-Year Follow-Up Study, Lynn El Haddad, Georgios Angelidakis, Yuting Zhai, Layale Yaghi, Cesar A Arias, Kwangcheol Casey Jeong

Faculty, Staff and Student Publications

Vancomycin-resistant enterococci (VRE) commonly colonize the gut of individuals with hematologic malignancies or undergoing hematopoietic cell transplant (HCT) and may cause bacteremia. In 2012, we identified VRE isolates from patients and patients' rooms and showed transmission networks of highly genetically related daptomycin-resistant (DR)-VRE strains. This is a follow-up study performing whole-genome sequencing (WGS) and phylogenetic analyses on 82 clinical VRE strains isolated from stools and blood cultures of patients with leukemia and HCT between 2015 and 2019. Here, we observed transmission of highly genetically related strains between rooms on the same or on different floors, including a DR-VRE strain identified …

Regulatory Complexity Of Cellular Differentiation In Candida Albicans Revealed Through Systematic Screening Of Protein Kinase Mutants, Michael C Lorenz

Faculty, Staff and Student Publications

A recent study in mBio reports the construction and preliminary screening of a library containing mutants of 99 of the 119 predicted protein kinases in Candida albicans (the majority of the remaining 20 are probably essential) (J. Kramara, M.-J. Kim, T. L. Ollinger, L. C. Ristow, et al., mBio e01249-24, 2024, https://doi.org/10.1128/mbio.01249-24). Using a quantitative competition assay in 10 conditions that represent nutritional, osmotic, cell wall, and pH stresses that are considered to model various aspects of the host environment allowed them to phenotypically cluster kinases, which highlight both the integration and specialization of signaling pathways, suggesting novel functions …

Growth Mindset, Sel, And Collaborative Learning Through Harry Potter, Karen Hoffman

Essays in Education

Since its publication in 1997, the Harry Potter novels by J.K. Rowling have been a source of wonder and enjoyment for readers of all ages. Yet, for the informed teacher, the novels move beyond a means of entertainment and serve as a source inspiration for students around the world to achieve their goals. Obtaining a growth mindset (Dweck, 2012) is woven throughout Rowling’s series filling its pages with lessons of adolescent accomplishment and success. Teachers can use these books to inspire their students to reach their goals through social emotional learning and growth mindset (Dweck, 2012), all while collaborating with …

The Colorado Center For Rural Education: Mitigating The Teacher Shortage In Colorado, Joey Laurx, Robert Fulton, Rosanne Fulton

Journal of Educational Research and Innovation

Colorado’s rural communities face challenges recruiting and retaining qualified teachers, leaders, and special service providers. The Colorado Center for Rural Education (CCRE) has created and implemented a comprehensive system for professional development of effective educators for rural school districts. The CCRE has expanded educator pathway programs, supported teacher preparation students who commit to student teaching in rural Colorado, facilitated a rural teacher leaders program that prepares teachers for expanded professional roles, developed a coordinated professional development network for rural educators, and cultivated rural education advocacy, scholarship, and grant writing. The CCRE’s outcomes include more student teachers, alternative teacher licensure candidates, …

Letter From The Editors, Alexandra Berardelli, Isabel Sullivan

Parnassus: Classical Journal

No abstract provided.

Aegyptiaca In Conversation: Egyptianizing Motifs In Pompeiian Art, Caroline Boardman

Parnassus: Classical Journal

No abstract provided.

Toil And Trouble: The Symbolism Of The Cauldron Simile Of Book Vii Of The Aeneid, Isabel Sullivan

Parnassus: Classical Journal

No abstract provided.

An Overview Of The Water Systems Of Pompeii, Andrew Whinney

Parnassus: Classical Journal

No abstract provided.

Interpretatio Romana: How Names Can Influence Myth And Belief, Jude Lynch

Parnassus: Classical Journal

No abstract provided.

Garum: Pompeii's Claim To Fame, Meagan Warren

Parnassus: Classical Journal

No abstract provided.