Digital Commons Network^™

Engineering Ecological Analysis Of Rise Of Huawei’S Harmonyos And Its Implications, Dazhou Wang, Yishi Lyu, Zhihuan Fu

Bulletin of Chinese Academy of Sciences (Chinese Version)

This study aims to explore the rise of the Harmony operating system from the perspective of engineering ecology. In the face of increasingly fierce global technological competition, Huawei, as a leading Chinese information technology enterprise, launched its self-developed HarmonyOS and has progressively built the Harmony ecosystem, providing foundational support for the development of all sectors. The development path of HarmonyOS can be divided into three main phases based on its strategic goals, technological and product characteristics, and ecological construction: the initial phase, the acceleration phase, and the transformation phase. It is revealed that, throughout this development, various construction strategies for …

Challenges And Recommendations For Building Open Source Innovation Ecosystem For Large-Models In China, Xin Wen, Chao Zhang, Rui Guo, Kaihua Chen, Ze Feng, Qigang Zhu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Addressing the current technological development issues that constrain the development of China’s large-scale model industry is needed to promote the continuous prosperity and development of the industry and enhance its international competitiveness. The study analyzes the significance of the open-source innovation ecosystem for the development of large-scale models in China. Based on reviewing the international experience of constructing the open-source innovation ecosystem, it further dissects the problems and challenges faced by the construction of the open-source innovation ecosystem for large-scale models in China and puts forward targeted suggestions. The study finds that the open-source innovation ecosystem for large-scale models in …

Research And Practice Of Digital Institute And Its System Framework, Jianjun Yu, Yue Wang, Kongmin Wang, Zhuomin Shi

Bulletin of Chinese Academy of Sciences (Chinese Version)

In the era of the digital economy, digital scientific research and digital government are both crucial components, serving as application scenarios enabled by new information technologies. Currently, the new generation of information technologies, especially artificial intelligence and big data, is instrumental in modernizing governance at scientific research institutions within Chinese Academy of Sciences (CAS). They notably drive paradigm shifts in scientific activities and accelerate the digital transformation of these institutions. The digital system formed by the digital transformation of management processes in scientific activities at research institutes is defined as the digital institute. This study analyzes the impact of digital …

Innovative Development Of China' Energy Models In Digital Economy Era, Junlian Gao, Bo Zhang, Guosheng Zhang, He Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

In the era of the digital economy, the explosive growth of massive data and emerging technologies has brought new opportunities and challenges to the development of energy models. This study is grounded in the historical context and current trends of energy model development, revisits the basic connotations of energy models and their narrow and broad distinctions, and analyzes the latest research progress and technological frontiers of both types of models from a global perspective. Focusing on domestic practices, it clarifies the urgent needs for China’s energy model development in the digital economy era, including achieving independent innovation, aligning with national …

Research And Implications Of The Us Clean Energy Strategy, Lanchun Li, Qing Liu, Wei Chen, Yun Tang, Jun Chen

Bulletin of Chinese Academy of Sciences (Chinese Version)

As the world enters a new period of carbon neutrality, the US government is actively building a clean energy innovation ecosystem through both internal and external measures. Systematically tracking and in-depth analysis of the intent, structure, approach, and other characteristics of the new phase of the US clean energy strategy is of practical significance to Chinese energy revolution. The US focuses on the strategic objectives of science and technology innovation, energy security, and infrastructure, and has constructed an innovation ecology characterized by technology lists, planning blueprints, full-chain research, and innovative subjects from the perspective of whole-government coordination, cross-institutional decision-making, deep …

Technology Governance And Governance Technology: From Perspective Of Regulatory Research On Blockchain Digital Assets, Yikai Wu, Guoan Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

The Outline of the 14th Five-Year Plan takes blockchain as one of the key industries of the digital economy, and a number of ministries and commissions have also made clear deployments to accelerate the innovative application of blockchain, promote the digital transformation of the industry, and promote the high-quality development of the economy and society in the policy documents related to the informatization of the industry. The regulation and governance of blockchain digital assets cannot be separated from the understanding and analysis of blockchain technology itself, and observing the development mechanism of blockchain digital assets from the scientific and technological …

Natural Resource Factors Promoting Urban And Rural Integrated Development In The New Era: Target Selection And Policy Design, Zhimin Zhang, Guohua Yuan, Ruilin Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Reconstructing the reverse flood of natural resource elements in rural and urban regional systems is the basic form of requirement for realizing urban-rural integration. Taking target selection-realistic obstacles-institutional demand-system construction as the logical main line, starting from the current situation of natural resource element allocation under the framework of urban-rural integrated development, it sorted out the problems existing in the urban-rural integrated development of natural resources such as asymmetrical property rights design, inconsistent bearing plans of various types, lack of natural resource revenue sharing mechanism, and poor asset flow channels and trading systems, with unified layout, power return, paid use, …

Profiling Academicians Characteristics Of Chinese Academy Of Sciences: Analysis Of Newly Elected Academicians From 2005 To 2023, Qing Liu, Xuange Ma, Xiaosong He

Bulletin of Chinese Academy of Sciences (Chinese Version)

The title of Academician of the Chinese Academy of Sciences (CAS) represents the highest accolade in China’s scientific research field. Profiling the characteristics of CAS academicians can provide crucial insights into the current state of scientific research in China and play a vital role in fostering innovation and cultivating talents for the society. This study conducted a comprehensive quantitative analysis of the birthplaces, ages, genders, educational backgrounds, institutional affiliations, and administrative roles of newly elected CAS academicians from 2005 to 2023. Several key findings are identified, including: (1) the majority of newly elected CAS academicians originate from eastern and central …

Basic Characteristics, Important Problems And Value Orientation Of China' Science And Technology Think Tanks, Xiaogang Ren, Yichao Gao, Fang Gao

Bulletin of Chinese Academy of Sciences (Chinese Version)

Implementing the innovation-driven development strategy is not only an important measure to modernize the national governance system and governance capacity, but also a vital component of the Chinese path to modernization. The significance of highquality development of technology-focused think tanks, characterized by their knowledge and technology intensity, is increasingly evident. China’s science and technology think tanks have always adhered to the value concept of the Party’s leadership and the principle of putting the people first. They have developed a diversified and comprehensive integration model for think tanks. They offer a range of interdisciplinary products and boast specialized, composite scientific and …

2023 Technology Focus: Reflecting The Situation And Technological High Grounds Of Latest Round Of Sci-Tech Revolution And Industrial Transformation, Guopeng Li, Lin Han, Jiaofeng Pan, Fuhai Leng, Feng Zhang, Fan Yang, Ying Xing, Haiming Wang, Weiwei Fan, Haixia Wang, Wenyue Bian, Ting Chen, Jianxia Yuan, Chaoxing Zhang, Longguang Huang, Xiaomei Wang, Song Yang, Ronggang Wang, Zanmei Li, Jie Chen, Bo Zhou, Zhen Sun, Rujiang Bai, Liying Zhou, Kunpeng Peng, Yang Gao, Guangfeng Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

In April 2024, the Institutes of Science and Development, Chinese Academy of Sciences (CASISD) released the 2023 Technology Focus report. The report uses big data and deep learning techniques to explore the hidden deep relationships among patent technologies. Based on 21 812 technology focuses formed by clustering nearly 680 000 dual jurisdictional patents, the Top 100 technology focuses are selected, named, and outlined in 32 technical fields distributed in the four major categories of the World Intellectual Property Organization (WIPO) patent classification system, and a key analysis and interpretation of 32 of them are also provided. This study is based …

Analysis Of Recent Development In Energy Storage Technology In China From Perspective Of Patents, Mingming Jiang, Zhijun Jin

Bulletin of Chinese Academy of Sciences (Chinese Version)

The achievement of the “dual carbon” goal is closely tied to the widespread implementation of renewable energy, however, renewable energy generation is characterized by intermittency and volatility. Advanced energy storage technology plays a crucial role in mitigating the fluctuations of new energy sources and enhancing their absorption capacity. Patents serve as important indicators of technological innovation, directly reflecting current research trends and future directions in energy storage technology. This paper primarily relies on the “WIPO IP Portal” website provided by the World Intellectual Property Organization to analyze the comprehensive strength of eight leading countries including the United States, China, France, …

Bp1003 Decreases Stat3 Expression And Its Pro-Tumorigenic Functions In Solid Tumors And The Tumor Microenvironment, Maria Gagliardi, Rhonda Kean, Bingbing Dai, Jithesh Augustine, Michael Roberts, Jason Fleming, D. Craig Hooper, Ana Ashizawa

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Overexpression and aberrant activation of signal transducer and activator of transcription 3 (STAT3) contribute to tumorigenesis, drug resistance, and tumor-immune evasion, making it a potential cancer therapeutic target. BP1003 is a neutral liposome incorporated with a nuclease-resistant P-ethoxy antisense oligodeoxynucleotide (ASO) targeting the STAT3 mRNA. Its unique design enhances BP1003 stability, cellular uptake, and target affinity. BP1003 efficiently reduces STAT3 expression and enhances the sensitivity of breast cancer cells (HER2⁺, triple negative) and ovarian cancer cells (late stage, invasive ovarian cancer) to paclitaxel and 5-fluorouracil (5-FU) in both 2D and 3D cell cultures. Similarly, ex vivo and in …

Synthesis And Characterization Of Nial-Hydride Heterometallics: Perturbing Electron Density Within Al–H–Ni Subunits, Aleida G. Gonzalez, Fernando Gonzalez, Edgar De Leon, Kaitlyn M. Birkhoff, Sam Yruegas, Haoyuan Chen, Manar Shoshani

School of Integrative Biological & Chemical Sciences Faculty Publications

Heterometallic hydride complexes are of growing interest due to their potential to contribute to highly active insertion-based catalysis; however, methods to modulate electron density within this class of molecules are underexplored. Addition of ancillary ligands to heterotrimetallic NiAl2H2 species (1) results in the formation of heterobimetallic NiAl-hydride complexes with varying phosphine donors (2-(L)2). Incorporation of sigma donating ancillary ligands of increasing strength led to contractions of the Ni–Al distances correlated to a strengthening of a back donation interaction to the Al–H sigma antibonding orbital, most prominently present in 2-(PMe3)2. Demethylation of the aryl ether from 2-(PMe3)2 provides access to a …

Free Energy Differences In Nonequilibrium Thermodynamic Processes, Paul Bracken

School of Mathematical & Statistical Sciences Faculty Publications

Systems which may be allowed to go out of equilibrium have been of interest recently. A quantity is formulated whose average over an ensemble of microscopic realizations of the process depends only on the initial and final states. This is so even though the system may not be in equilibrium during the process. A generalization to the case where the initial and final states are not equilibrium states is developed here. Quantum analogues of these relations are derived, and an indication of how this might be applied to study entropy increase in thermodynamics is presented.

Thermal Regimes Of Beaver Impacted Stream Reaches In The Tualatin River Basin, Miles Mayer

Dissertations and Theses

Climate change and urbanization are expected to cause major changes to hydrologic regimes over the Pacific Northwest Region. The Tualatin River Basin, an area of the Pacific Northwest just west of Portland, OR has been subjected to considerable water-quality issues, including stream temperature. As ecosystem engineers, beavers have the potential to mitigate stream degradation and, consequently, there is increasing interest in beaver-related restoration. However, different conclusions have been found on beaver dam impacts to stream thermal regimes. These differences have been attributed to geographical differences in study location and variability in methods and investigated spatiotemporal scales. We investigated summer thermal …

Design Of Novel Inhibitors For Ischemia/Reperfusion Injury Targeting Ferroptosis, Xuyang Wang, Qiming Deng, Jingchen Hou, Kalyan Kumar Pasunooti, Kevin C. Bermea, Kai Li, Genaro Antonio Ramirez-Correa

School of Medicine Publications

No abstract provided.

A Second Homotopy Group For Digital Images, Gregory Lupton, Oleg R. Musin, Nicholas A. Scoville, P. Christopher Staecker, Jonathan Treviño-Marroquín

School of Mathematical & Statistical Sciences Faculty Publications

We define a second (higher) homotopy group for digital images. Namely, we construct a functor from digital images to abelian groups, which closely resembles the ordinary second homotopy group from algebraic topology. We illustrate that our approach can be effective by computing this (digital) second homotopy group for a digital 2-sphere.

Spatial Optimism And Cross-Over Effects In The Perceptions Of Interconnected Wildfire, Flood, And Mudslide Hazards, Douglas Houston, Omar Pérez Figueroa, Ariane Jong-Levinger, Brett F. Sanders

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Communities near the wildland urban interface (WUI) are exposed to a mix of three interconnected hazards (wildfire, flood, and mudslide), and understanding multi-hazard perceptions is critically important for emergency preparation and hazard mitigation—particularly given the WUI’s rapid expansion and intensifying environmental hazards. Based on a survey of residents living near recent burn scars in Southern California, we document cross-over effects in hazard perceptions, where resident experience with one hazard was associated with greater hazard rankings for other hazards. Additionally, for all three hazards analyzed we document perceptions of increasing hazard levels with increasing spatial scales (home, near-home, neighborhood, and community), …

Clinical And Genomic-Based Decision Support System To Define The Optimal Timing Of Allogeneic Hematopoietic Stem-Cell Transplantation In Patients With Myelodysplastic Syndromes, Cristina Astrid Tentori, Caterina Gregorio, Marie Robin, Nico Gagelmann, Carmelo Gurnari, Juan Carlos Caballero Berrocal, Saverio D'Amico, Marta Spreafico, Giulia Maggioni, Erica Travaglino, Elisabetta Sauta, Manja Meggendorfer, Lin-Pierre Zhao, Alessia Campagna, Victor Savevski, Armando Santoro, Najla Al Ali, David Sallman, Francesc Sole, Guillermo Garcia-Manero, Ulrich Germing, Nicolaus Kroger, Shahram Kordasti, Valeria Santini, Guillermo Sanz, Wolfgang Kern, Uwe Platzbecker, Maria Diez-Campelo, Jaroslaw P Maciejewski, Lionel Ades, Pierre Fenaux, Torsten Haferlach, Amer M Zeidan, Gastone Castellani, Rami Komrokji, Francesca Ieva, Matteo Giovanni Della Porta, Genomed4all And Synthema Consortiums

Faculty, Staff and Student Publications

Purpose: Allogeneic hematopoietic stem-cell transplantation (HSCT) is the only potentially curative treatment for patients with myelodysplastic syndromes (MDS). Several issues must be considered when evaluating the benefits and risks of HSCT for patients with MDS, with the timing of transplantation being a crucial question. Here, we aimed to develop and validate a decision support system to define the optimal timing of HSCT for patients with MDS on the basis of clinical and genomic information as provided by the Molecular International Prognostic Scoring System (IPSS-M).

Patients and methods: We studied a retrospective population of 7,118 patients, stratified into training and validation …

Impacts Of Interleukin-10 Promoter Genotypes On Prostate Cancer, Yu-Ting Chin, Chung-Lin Tsai, Hung-Huan Ma, Da-Chuan Cheng, Chia-Wen Tsai, Hou-Yu Shih, Jian Gu, Wen-Shin Chang, Da-Tian Bau

Faculty, Staff and Student Publications

Prostate cancer (PCa) is a multifactorial disease influenced by genetic, environmental, and immunological factors. Genetic polymorphisms in the interleukin-10 (IL-10) gene have been implicated in PCa susceptibility, development, and progression. This study aims to assess the contributions of three IL-10 promoter single nucleotide polymorphisms (SNPs), A-1082G (rs1800896), T-819C (rs3021097), and A-592C (rs1800872), to the risk of PCa in Taiwan. The three IL-10 genotypes were determined using PCR-RFLP methodology and were evaluated for their contributions to PCa risk among 218 PCa patients and 436 non-PCa controls. None of the three IL-10 SNPs were significantly associated with the risks of …

Comparative Treatment Of Homeless Persons With An Infectious Disease In The Us Emergency Department Setting: A Retrospective Approach, Jessica Barnes, Larry Segars, Jason A. Wasserman, Patrick Karabon, Tracey A.H. Taylor

Faculty and Staff Publications

Background: Research has long documented the increased emergency department usage by persons who are homeless compared with their housed counterparts, as well as an increased prevalence of infectious diseases. However, there is a gap in knowledge regarding the comparative treatment that persons who are homeless receive. This study seeks to describe this potential difference in treatment, including diagnostic services tested, procedures performed and medications prescribed.

Methods: This study used a retrospective, cohort study design to analyse data from the 2007-2010 United States National Hospital Ambulatory Medical Care Survey database, specifically looking at the emergency department subset. Complex sample logistic regression …

Launching The Clostridioides Difficile Collection, Lovleen Tina Joshi, Stephen Michell, Ed J. Kuijper

Peninsula Dental School

No abstract provided.

Evaluation Of Open-Source Ciliary Analysis Software In Primary Ciliary Dyskinesia: A Comparative Assessment, Zachary J Demetriou, José Muñiz-Hernández, Gabriel Rosario-Ortiz, Frances M Quiñones, Gabriel Gonzalez-Diaz, Marcos J Ramos-Benitez, Ricardo A Mosquera, Wilfredo De Jesús-Rojas

Faculty, Staff and Student Publications

Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder characterized by alterations in motile cilia function. The diagnosis of PCD is challenging due to the lack of standardized methods in clinical practice. High-speed video microscopy analysis (HSVA) directly evaluates ciliary beat frequency (CBF) in PCD. Recently, open-source ciliary analysis software applications have shown promise in measuring CBF accurately. However, there is limited knowledge about the performance of different software applications, creating a gap in understanding their comparative effectiveness in measuring CBF in PCD. We compared two open-source software applications, CiliarMove (v219) and Cilialyzer (v1.2.1-b3098cb), against the manual count method. We …

Influence Of Pathophysiologic Patterns Of Coronary Artery Disease On Immediate Percutaneous Coronary Intervention Outcomes, Hitoshi Matsuo, Simone Biscaglia, Fernando Rivero, Thomas Engstrøm, Ketina Arslani, Antonio Maria Leone, Lokien X Van Nunen, William F Fearon, Evald Høj Christiansen, Stephane Fournier, Liyew Desta, Andy Yong, Julien Adjedj, Javier Escaned, Masafumi Nakayama, Ashkan Eftekhari, Frederik M Zimmermann, Koshiro Sakai, Tatyana Storozhenko, Bruno R Da Costa, Gianluca Campo, Nick E J West, Tom De Potter, Ward Heggermont, Dimitri Buytaert, Jozef Bartunek, Colin Berry, Damien Collison, Thomas Johnson, Tetsuya Amano, Divaka Perera, Allen Jeremias, Ziad Ali, Nico H J Pijls, Bernard De Bruyne, Nils P Johnson

Faculty, Staff and Student Publications

Background: Diffuse coronary artery disease affects the safety and efficacy of percutaneous coronary intervention (PCI). Pathophysiologic coronary artery disease patterns can be quantified using fractional flow reserve (FFR) pullbacks incorporating the pullback pressure gradient (PPG) calculation. This study aimed to establish the capacity of PPG to predict optimal revascularization and procedural outcomes.

Methods: This prospective, investigator-initiated, single-arm, multicenter study enrolled patients with at least one epicardial lesion with an FFR ≤0.80 scheduled for PCI. Manual FFR pullbacks were used to calculate PPG. The primary outcome of optimal revascularization was defined as an FFR ≥0.88 after PCI.

Results: A total of …

From Fan Blogs To Fruits Basket: Documenting The Resources Of Anime And Manga Studies Libguides, Billy Tringali, Vibu Logendran

Proceedings from the Document Academy

Anime and manga have seen exponential growth in market value, and popularity, over the last decade. This boom of popularity for anime has been matched in recent years by an increased interest from fans in anime and manga studies. This project seeks to document the contents of anime studies research guides, with the goal of seeing what specific resources, popular media, and fan media like blogs, are listed within these guides and recommended to fans seeking to explore this budding area of scholarship.

Utilizing Metadata From Heterogeneous Sources Within The Framework Of The Jvmg And Golem Projects To Identify Patterns In Anime-Based Fandoms On Ao3, Zoltan Kacsuk, Xiaoyan Yang, Saskia Dreßler, Federico Pianzola, Martin Roth

Proceedings from the Document Academy

This paper offers an overview of the first step in the data alignment and joint research efforts between the Japanese Visual Media Graph (JVMG) and the Graphs and Ontologies for Literary Evolution Models (GOLEM) projects. Focusing on fully or in-part anime based fandoms in the Archive of Our Own (AO3) data in the GOLEM knowledge graph we connected 534 fandoms with 1,734 anime works from the JVMG knowledge graph. The fanfiction publication numbers and dates for these fandoms were then analyzed in conjunction with the various metadata available on the corresponding anime works, such as release date, genre, content rating …

Fanfiction: When Copyright Violation Benefits Brands, Ethan Milne, Kirk Kristofferson, Miranda Goode

Proceedings from the Document Academy

We investigate fanfiction (i.e., original fiction adopting elements of pre-existing media), as a copyright-violating phenomenon and show it can benefit brands. Our work first identifies two benefits of fanfiction: 1) reading fanfiction increases purchase intent for brand content, 2) and fanfiction production rates can be used to generate more accurate estimates of next-week TV viewership. Next, we identify that brands can grow their fanfiction communities by waiving copyright protection, thus removing a barrier to publication faced by many fanfiction authors. We demonstrate these results using two real-world datasets representing billions of words of fanfiction content, and one lab study (N=600).

Fanfic! In The Library: What Can Be Learnt From How Readers Search For Fics?, Rowan Smith

Proceedings from the Document Academy

This research seeks to explore the use of fanfiction-specific language (FSL) within the fanfiction community and whether fanfiction readers would find it useful if FSL was incorporated into library catalogues. The aims of the research are to investigate how fanfiction readers learn, use and interact with FSL and to explore if incorporating FSL into public library catalogues would encourage use. A mixed-methods approach was taken – participants were surveyed using a questionnaire and follow-up interviews, which were analysed using descriptive statistics and coding following the constant comparative analysis process. The major findings of the study are that fanfiction readers largely …

Archiving The Ephemeral In Digital Public Space: Using Speculative Design To Consider Collaborative Fan Play In The Metaverse, Naomi Jacobs

Proceedings from the Document Academy

Looking at fan activity through the lens of play, this paper considers the archiving opportunities and challenges posed by new technology for playful ephemeral fan co-creation in multiplatform digital contexts. These include technical concerns such as platform fragility and how to capture inherent liveness and temporality, but also ethical concerns such as sustainability, consent and content moderation.

To examine this, the paper takes fan-created alternate reality games (ARGs) as a particular example of such archiving challenges. It first describes a real example of such a game, ‘Blow the Man Down’ before introducing speculative design as a method to consider a …

Investigating Veterinarians' Interest In Mental Health, Loren C. Beggs, Jisook Park

Academic Leadership Journal in Student Research

Stress affects all individuals though individuals’ response to stressors can be different. When stress is not managed effectively, it can lead to severe physiological concerns as well as psychological damages such as depressive symptoms and even suicidal ideations. Veterinarians are known to have a higher depression level and suicide rate than the general population which could be attributed to higher occupational stress. The purpose of the current study is to investigate the mental health state of veterinarians and the relationship between psychological distress and pursuit of mental health resources. We also explored the relationship between psychological distress and perceived importance …