Digital Commons Network^™

Calibration And Validation Of An Ogden Material Model For Thermoplastic Polyurethane In 3d-Printed Tensegrity Structures, Caleb C. Swain

Theses and Dissertations

This work is motivated by ongoing efforts within the Smart Materials, Adaptronics, and Shock Laboratory (SMASH Lab) at Brigham Young University (BYU) to develop variable-stiffness, external fixators using 3D-printed tensegrity structures. In the process of designing and evaluating these systems, the need arose to accurately model the nonlinear mechanical behavior of thermoplastic polyurethane (TPU), the primary material used in prototype fabrication. This thesis investigates how accurately a calibrated Ogden material model can predict the nonlinear mechanical response of TPU in 3D-printed tensegrity structures. Experimental data were used to calibrate the parameters of the hyperelastic constitutive model through nonlinear optimization. An …

Pengaruh Intervensi Sigo Terhadap Perbaikan Postur Kerja Dan Penurunan Keluhan Musculoskeletal Disorders Pada Pekerja Sewing Di Cv X Sukoharjo, Sumardiyono Sumardiyono, Tiara Damar Pratiwi, Warda Yussy Rha

National Journal of Occupational Health and Safety

Sewing workers in the garment industry are at high risk of developing non-ergonomic working postures that may lead to musculoskeletal disorders (MSDs), due to prolonged static postures and the use of chairs that are not compatible with workers’ anthropometry. Preliminary surveys indicated complaints of pain in the back, neck, and waist (90%), shoulders and forearms (85%), and upper arms (80%). An ergonomic intervention that can be implemented is the use of ergonomic chairs. This study aims to analyze the effect of using SIGO (Seat Improvement for Garment Operators) as an ergonomic intervention on improving working posture and reducing MSD complaints …

Urban Indian Parents' Occupational Perceptions Of Play And Governance Of Children's Excessive Screen Time Preferences And Behaviours In This Digital Era, Joanna Priyadarshini Udaykumar, Tony Sam George

International Journal of Playwork Practice

Abstract

Children’s innate urge to engage in joyous, self-directed, meaningful, iterative activities embodies their unique play experiences and facilitates their holistic development. However, the exponential growth of digital technology in an urbanized world has transformed their social landscape by offering them a plethora of novel play opportunities that ‘pushes children away from the outdoors and pulls them indoors’. Moreover, the radical transition from nature-based recreation to media-centric activity insinuates the surge of a global pandemic characterized by low physical activity, sleep deprivation and sedentary, lifestyle diseases. This emerging trend reflects children’s predilection for videophilia over biophilia due to the dominance …

Passion For Accurate Journalism Fuels Support, Bill Dabney

University of Mississippi News

OXFORD, Miss. – A lifelong belief in the power of accurate journalism, along with a personal connection to the profession, led Missy Pace Callero to support a new initiative shaping the future of news produced from the University of Mississippi.

Institutional Influences And The Governance And Administration Of The Programa Produtor De Água Payment For Ecosystem Services Program In Brazil, Thomas G. Safford

Faculty Publications

Payment-for-Ecosystem-Services (PES) has been promoted as an innovative approach to environmental governance capable of simultaneously advancing conservation and sustainable development objectives. While studies commonly assess the ecological and economic performance of PES schemes, less attention has been given to their organizational and administrative effectiveness. This study examines these governance dimensions of one of Latin America’s most prominent PES initiatives—the Water Producer Program (WPP) in Brazil. Drawing on a meta-synthesis of 125 publications, the analysis investigates how regulative, normative, and cultural-cognitive institutional forces shaped WPP implementation. Guided by neo-institutional theory and institutional bricolage, findings show that WPP governance operated through hybrid …

Evolution And Assessment Of Employee/Workplace Services, David L. Groves

Visions in Leisure and Business

No abstract provided.

Motivational Interviewing Impact On Outcomes Is Affected By Level Of Interventionist Training: A Review Of Systematic Reviews, Sneha Gaonkar, Jan Kavookjian, Heqin Yang

Podiums

ackground: Motivational Interviewing (MI) involves interviewing a person in an autonomy-supporting, person-centered, encouraging way, eliciting the individuals internal change motivations. Thirteen modified Cochrane method (MCM) systematic reviews of MI impact on outcomes included varied populations, interventionist types, and target outcomes with a lens for whether MI training of interventionists was reported and/or met evidence-based MI training guidelines. The objective of this study was to review MI training reported in 126 retained articles across MCM MI reviews and describe level of evidence-based MI training reported. Methods: Each MCM review, published between 2012 to present, aimed to explore and report evidence and …

Real-World Impact Of Fda Opioid Regulatory Actions On Prescribing And Patient Outcomes: A Systematic Review, Millicent Boakye, Gabriel Ezenri

Posters

Background: Since 2013, the United States Food and Drug Administration (FDA) has issued a sustained series of opioid regulatory actions to curb high-risk prescribing and opioid-related harm. The impact of these actions on real-world prescribing and patient safety outcomes remains uncharacterized. This study aims to synthesize observational data on the real-world impact of FDA opioid regulatory actions and Risk Evaluation and Mitigation Strategies (REMS) on prescribing behavior and patient outcomes. Methods: We conducted a systematic review following the PRISMA 2020 guidelines. We search in Pubmed, Embase and Web of science for studies published between September 2013 and September 2025.The eligible …

Reducing Opioid Exposure Through State Policy: Evidence From U.S. Prescribing Limits, Rasaq Oladapo, Olufunmilola Abraham, Patricia R. Freeman, Douglas Oyler, Rachel Vickers-Smith

Podiums

Background: Initial opioid prescribing for acute pain contributes substantially to opioid exposure and can drive persistent use, increasing the risk of overdose and opioid use disorder. Most U.S. states have implemented opioid prescribing limits (OPLs) to restrict initial opioid prescription duration, quantity, or dosage. However their intended and unintended impacts remain poorly understood. This narrative review summarizes evidence from U.S. studies evaluating the impact of OPLs on prescribing, patient, and public health outcomes, while identifying gaps and priorities for future research. Methods: We reviewed U.S. studies published between April 2016 and January 2026 evaluating statutory OPLs. Literature was identified through …

Patients Willingness To Seek Help From Pharmacists In The Management Of Rheumatoid Arthritis: A Qualitative Study, Omkar Ghodke, Erin Holmes, Meagen Rosenthal, Yinan Huang, Marie Barnard

Podiums

Background: This study explored the willingness of rheumatoid arthritis (RA) patients to seek help from pharmacists for their disease management. While pharmacist interventions are known to enhance medication adherence and health outcomes, patient engagement with pharmacists remains low. Understanding the factors that influence RA patients' willingness to use pharmacy services is essential for improving patient outcomes and optimizing the role of pharmacists in RA management. Using the Integrative Model of Behavioral Prediction (IMBP), this study identified the factors influencing willingness to use pharmacists and pharmacy services among patients with RA. Methods: This study utilized semi-structured interviews targeting individuals 26 years …

Gwtc-4.0: Updating The Gravitational-Wave Transient Catalog With Observations From The First Part Of The Fourth Ligo–Virgo–Kagra Observing Run, A. G. Abac, I. Abouelfettouh, Teviet Creighton, Mario C. Diaz, Raul Alberto Espinosa Perez, J. Lawrence, Francisco Llamas Villarreal, Soma Mukherjee, Volker Quetschke, Miriam Ramos Arevalo, Wenhui Wang

Physics & Astronomy Faculty Publications

Version 4.0 of the Gravitational-Wave Transient Catalog (GWTC-4.0) adds new candidates detected by the LIGO, Virgo, and KAGRA observatories through the first part of the fourth observing run (O4a: 2023 May 24 15:00:00 to 2024 January 16 16:00:00 UTC) and a preceding engineering run. In these new data, we find 128 compact binary coalescence candidates that are identified by at least one of our search algorithms with a probability of astrophysical origin pastro ≥ 0.5 and that are not vetoed during event validation. We also provide detailed source property measurements for 86 of these that have a false-alarm rate …

Open Data From Ligo, Virgo, And Kagra Through The First Part Of The Fourth Observing Run, Ligo Scientific Collaboration, Virgo Collaboration, Kagra Collaboration, Marc Favata, Shoan Ghosh, Rodica Martin

Department of Physics and Astronomy Faculty Scholarship and Creative Works

LIGO, Virgo, and KAGRA form a network of gravitational-wave observatories. Data and analysis results from this network are made publicly available through the Gravitational Wave Open Science Center. This paper describes open data from this network, including the addition of data from the first part of the fourth observing run and selected periods from the preceding engineering run, collected from 2023 May to 2024 January. The public dataset includes calibrated strain time series for each instrument, data from additional channels used for noise subtraction and detector characterization, and analysis data products from version 4.0 of the Gravitational-Wave Transient Catalog.

Gwtc-4.0: Methods For Identifying And Characterizing Gravitational-Wave Transients, Ligo Scientific Collaboration, Virgo Collaboration, Kagra Collaboration, Marc Favata, Shoan Ghosh, Rodica Martin

Department of Physics and Astronomy Faculty Scholarship and Creative Works

The Gravitational-Wave Transient Catalog (GWTC) is a collection of candidate gravitational-wave transient signals identified and characterized by the LIGO-Virgo-KAGRA Collaboration. Producing the contents of the GWTC from detector data requires complex analysis methods. These comprise techniques to model the signal; identify the transients in the data; evaluate the quality of the data and mitigate possible instrumental issues; infer the parameters of each transient; compare the data with the waveform models for compact binary coalescences; and handle the large amount of results associated with all of these different analyses. In this paper, we describe the methods employed to produce the catalog's …

Gw230814: Investigation Of A Loud Gravitational-Wave Signal Observed With A Single Detector, Ligo Scientific Collaboration, Virgo Collaboration, Kagra Collaboration, Marc Favata, Shoan Ghosh, Rodica Martin

Department of Physics and Astronomy Faculty Scholarship and Creative Works

GW230814, detected by the LIGO Livingston observatory with a signal-to-noise ratio of 42.4, represents the loudest gravitational-wave signal in the GWTC-4.0 catalog. Its source is consistent with a binary black hole coalescence with component masses m(1) = 33.7(-2.2)(+2.9) M-circle dot and m(2) = 28.2(-3.1)(+2.2) M-circle dot and a small effective inspiral spin chi(eff) = -0.01(-0.07)(+0.06). The high signal-to-noise ratio enabled us to detect an l = vertical bar m vertical bar = 4 mode in the inspiral-merger-ringdown signal for the first time (with Bayes factor approximate to 10), as well as enabling a range of tests of consistency between theoretical …

Gwtc-4.0: Updating The Gravitational-Wave Transient Catalog With Observations From The First Part Of The Fourth Ligo-Virgo-Kagra Observing Run, Ligo Scientific Collaboration, Virgo Collaboration, Kagra Collaboration, Marc Favata, Shoan Ghosh, Rodica Martin

Department of Physics and Astronomy Faculty Scholarship and Creative Works

Version 4.0 of the Gravitational-Wave Transient Catalog (GWTC-4.0) adds new candidates detected by the LIGO, Virgo, and KAGRA observatories through the first part of the fourth observing run (O4a: 2023 May 24 15:00:00 to 2024 January 16 16:00:00 UTC) and a preceding engineering run. In these new data, we find 128 compact binary coalescence candidates that are identified by at least one of our search algorithms with a probability of astrophysical origin p(astro) >= 0.5 and that are not vetoed during event validation. We also provide detailed source property measurements for 86 of these that have a false-alarm rate <1 yr(-1). Based on the inferred component masses, these candidates are consistent with signals from binary black holes (BBHs) and neutron star-black hole binaries (GW230518_125908 and GW230529_181500). Median-inferred component masses of BBHs in the catalog now range from 5.79M(circle dot) (GW230627_015337) to 137M(circle dot) (GW231123_135430), while GW231123_135430 was probably produced by the most massive binary observed in the catalog. For the first time, we have discovered BBH signals with network signal-to-noise ratio exceeding 30, GW230814_230901 and GW231226_101520, enabling high-fidelity studies of the waveforms and astrophysical properties of these systems. Combined with the 90 candidates included in GWTC-3.0, the catalog now contains 218 candidates with p(astro) >= …

Searches For Continuous Gravitational Waves From Supernova Remnants In The First Part Of The Ligo-Virgo-Kagra Fourth Observing Run, Ligo Scientific Collaboration, Virgo Collaboration, Kagra Collaboration, Marc Favata, Shoan Ghosh, Rodica Martin

Department of Physics and Astronomy Faculty Scholarship and Creative Works

We present results from directed searches for continuous gravitational waves from a sample of 15 nearby supernova remnants, likely hosting young neutron star candidates, using data from the first eight months of the fourth observing run (O4) of the LIGO-Virgo-KAGRA Collaboration. The analysis employs five pipelines: four semicoherent methods-the Band-Sampled-Data directed pipeline, Weave, and two Viterbi pipelines (single- and dual-harmonic)-and PyStoch, a cross-correlation-based pipeline. These searches cover wide frequency bands and do not assume prior knowledge of the targets' ephemerides. No evidence of a signal is found from any of the 15 sources. We set 95% confidence-level upper limits on …

The Effect Of Flaxseed Oil On Fertility, Mohammad F. Albadran, Ahmed B. Abdulwahid, Assad H. Eissa, Nehaya M. Al-Aubody, Shaymaa F. Abbas, Zainab M. Mohammed

Hilla University College Journal For Medical Science

Background: Infertility can be defined as the inability to conceive pregnancy when sexually active and not having used any contraception in 12 months. Flaxseed oil has wide-spectrum applications in health. It has been receiving special interest in infertility treatment.

Objectives: This research aimed to determine the impact of flaxseed oil on the fertility of mice.

Methods: It involved seventy-five mice. These mice were sex-separated and randomly classified into three groups; one group served as a control group, and the other two groups were exposed to flaxseed oil extract at a dose of 60 mg/Kg body weight/day or 120 mg/Kg body …

Factors Associated With Discharge Against Medical Advice Among Patients Attending The Emergency Departments In Babylon Governorate, Hasan Alwan Baiee, Ali Mohsen Al-Jobury, Ola Mosheb

Hilla University College Journal For Medical Science

Background: With the increasing number of patients leaving the emergency department against medical advice, morbidity, mortality, and readmission rates have risen, placing a strain on the healthcare system.

Objectives: This study aimed to identify the demographic characteristics and the reasons why patients left against medical advice among those attending the emergency departments of teaching hospitals in Babylon Governorate.

Materials and Methods: A descriptive cross-sectional study was conducted in Babylon Governorate, encompassing three hospitals. using a convenience sample of patients who left the hospital against their physician's advice. Data were collected between August 2024 and February 2025 using a semi-structured questionnaire …

Evaluation Of The Oxidative Effect Of Magnetic Resonance Imaging (Mri) On Patients With Type 1 Diabetes, With And Without The Use Of Gadolinium Contrast Agent, Dunya Ali Mustafa

Hilla University College Journal For Medical Science

Background: Type-1 diabetes (T1D) is one of the most prevalent chronic autoimmune diseases, which is characterized by the progressive destruction of insulin-secreting β cells. Evidence indicates that repeated or high-dose exposure to Gadolinium-Based Contrast Agents (GBCAs) during MRI can result in long-term tissue deposition and increased oxidative stress.

Objectives: This study aimed to estimate the oxidative effects of MRI exposure in patients with type-1 diabetes, before and after gadolinium contrast, for different time intervals, using cyclic voltammetry (CV) as an electrochemical analysis tool.

Materials and Methods: The study was performed at Ghazi Al-hariri Hospital in Baghdad, Iraq, from January to …

Plasma Vegf-A, Vegfr-2, And Asprosin Levels In Poorly Controlled Type 2 Diabetes, Safaa Shehab Ahmed, Ishtar Imad Majeed, Muhammad Talib Hussein, Amany Lotfy Omar, Dhuha Khaled Hadid, Maha Radam Lateef

Hilla University College Journal For Medical Science

Background: Poorly controlled type 2 diabetes is marked by endothelial dysfunction and disrupted glucose metabolism. VEGF-A and VEGFR-2 drive vascular repair, while asprosin contributes to insulin resistance.

Objectives: This study explored the association of these biomarkers in individuals with poorly controlled T2DM.

Methods: The study included 100 patients with type 2 diabetes mellitus (T2DM) and 60 age-matched healthy controls (45–65 years). Glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) were measured using a Roche Cobas Integra 400 Plus analyzer. Serum levels of VEGF-A, VEGFR-2, and asprosin were quantified using ELISA.

Results: T2DM patients exhibited significantly elevated serum levels of VEGF-A, …

Molecular Characterization And Genotyping Of Candida Species Isolated From The Nasal Cavity Of Patients With Nasal Infections In Iraq, Amran M. Al-Erjan, Hind Tahseen Ibrahim

Hilla University College Journal For Medical Science

Background: Nasal infections are commonly associated with opportunistic microorganisms, particularly Staphylococcus aureus and Candida species.

Objectives: This study aimed to molecularly characterize Candida species isolated from the nasal cavity of patients with nasal infections and to determine their phylogenetic relationships using the internal transcribed spacer (ITS) region.

Methods: A total of 88 nasal swab samples were collected from patients aged 1–80 years in Thi-Qar Province, Iraq, between December 2023 and March 2024. Samples were cultured on Sabouraud Dextrose Agar and Mannitol Salt Agar. Yeast isolates were identified phenotypically using CHROMagar Candida and germ tube tests. Molecular identification and genotyping were …

Knowledge, Attitudes, And Practices Toward Pharmacovigilance And Adverse Drug Reaction Reporting Among Healthcare Professionals In Iraq: A Cross-Sectional Study, Hajir Karim Abdul-Husseein, Noor Abdalwahd Abood, Karam Akram Al-Akkam

Hilla University College Journal For Medical Science

Background: Pharmacovigilance is critical for approving medication safety; yet, underreporting of adverse drug reactions (ADRs) remains common.

Objectives: This cross-sectional study aimed to assess the knowledge, attitudes, and practices of healthcare professionals in Karbala and Babylon, Iraq, using a structured paper-based questionnaire.

Materials and Methods: This study utilized healthcare professionals in Holy Karbala and Babylon to explore their demographic profiles, pharmacovigilance knowledge, attitudes, and reporting practices. Results: Among 194 participants, most demonstrated positive attitudes toward ADR reporting, but notable gaps in knowledge and reporting behavior were observed. Pharmacists showed significantly higher knowledge levels than other professions, and formal training was …

Association Between Stress And Prolactin Hormone Levels: A Mini-Review, Sara Salah Mahdi, Huda S. Abdulghani

Hilla University College Journal For Medical Science

The physiological functions of prolactin are highly varied, despite the fact that it is most commonly recognized for its participation in the inhibition of reproduction and the regulation of breastfeeding. The conditions known as hyperprolactinemia can have a variety of origins, some of which are physiological and others of which are pathologic. The following are examples of physiological causes: pregnancy, breastfeeding, sleep-related, stimulation of the nipples and sexual orgasm, stimulation or trauma to the chest wall. Another significant physiological factor that contributes to hyperprolactinemia is stress, and the clinical importance of this factor is currently being investigated. This paper aims …

Antibiotic Resistance And Sensitivity Patterns In Pneumonia Pathogens: A Comprehensive Study Of Bacterial Isolates And Their Implications For Treatment In Diyala Province, Anfal Abd_Ulmunem Rasheed, Anfal Shakir Motib, Rafid Abdul-Mahdi Hasani

Hilla University College Journal For Medical Science

Background: Pneumonia is an inflammatory process affecting the airways and lung parenchyma, characterized by alveolar inflammation that leads to infiltration and consolidation of the lungs and disruption of gas exchange, which may result in respiratory distress.

Objectives: This study aims to identify the bacterial species that cause pneumonia and to determine their antibiotic resistance patterns.

Methods: This cross-sectional observational study assessed antibiotic resistance among patients with pneumonia in Diyala Province. Patients were identified from hospital and laboratory records over a four-month period (December 1st, 2024 - March 29th, 2025), yielding 100 patients, comprising 55 males and 45 females.

Results: The …

Molecular Detection Of Virulence Genes And Antibiotic Resistance In Uropathogenic Escherichia Coli: Focus On Babylon Province, Iraq, Lara Hashem Abdzaid, Tiba Habeeb Saifi, Jwan Ahmed Ali, Layth Jasim Mohammed, Isaac Karimi

Hilla University College Journal For Medical Science

Background: Urinary tract infections (UTIs) affect individuals of all ages, with uropathogenic Escherichia coli (UPEC) being their primary causative agent. The accumulation rate of antimicrobial resistance poses a major public health challenge, underscoring the need for genetic monitoring of resistant strains.

Objectives: This study aimed to find virulence genes and antibiotic resistance in UPEC.

Materials and Methods: 110 patients, including 65 females and 45 males, aged 15 to 40 years, were screened for UPEC at Al-Hilla city between January and March 2025. Urine samples were collected to identify E. coli and to analyze associated virulence factors.

Results: Biochemical tests confirmed …

Fragile Hope And The Cultural Life Of Law, Shefali Jain

Socio-Legal Review

This review of Sandhya Fuchs’ Fragile Hope: Seeking Justice for Hate Crimes in India (Stanford University Press 2024) highlights that the book makes a genuinely original ethnographic and conceptual contribution to caste studies and hate crime scholarship. At the same time, the essay argues that there are three limitations to its framework that require greater engagement: the book’s failure to engage with the legal consciousness tradition in socio-legal scholarship, an underdeveloped account of “legal meliorism,” and an unresolved tension between the book’s stated commitment to victim-centred analysis and its ethnographic evidence that frequently discusses movement-level aspirations.

Artificial Intelligence Empowers Particle Physics And Nuclear Physics: From Fundamental Research To Major Applications, Yifang Wang, Yuan He, Yao Huang, Wanbing He, Yi Jiao, Congqiao Li, Ke Li, Beijiang Liu, Yingqi Ma, Yugang Ma, Longgang Pang, Fazhi Qi, Sichao Tan, Chunpeng Wang, Meng Wang, Xiaoheng Xu, Xing Xu, Zhentang Zhao, Yingxun Zhang, Zhengde Zhang, Hongwei Zhao, Lina Zhao

Bulletin of Chinese Academy of Sciences (Chinese Version)

Particle physics and nuclear physics are core foundational disciplines for exploring the fundamental structure of matter and the origin of the universe. The deep integration of artificial intelligence (AI) technology is providing entirely new pathways to address systemic challenges such as the processing of massive amounts of multimodal data, the realization of extreme experimental conditions, bottlenecks in theoretical calculations, and the intelligent control of large-scale scientific facilities. The article systematically elaborates on how AI deeply empowers particle physics and nuclear physics, particularly in major application scenarios such as research on the fundamental structure and origin of mass of matter, the …

Consolidating Chemical Substance Creation Capability Through Ai For Science-Enabled Innovation Equity, Mengchu Jin, Wandong Wang, Jun Zhang, Yi Luo, Zaiku Xie, Jinlong Yang, Jun Jiang

Bulletin of Chinese Academy of Sciences (Chinese Version)

AI for Science (hereinafter referred to as AI4S) is driving profound changes in the paradigm of scientific research. Chemistry, as a central discipline for creating new substances and supporting major national strategic needs such as energy, health, dual carbon goals, advanced manufacturing, and ecological governance, is an important application scenario of AI4S. At present, innovation in the discipline of chemistry by young researchers still faces knowledge silos, capability silos, and resource silos: the accumulation of professional knowledge requires years of effort, frontier knowledge is highly differentiated, experimental capabilities are difficult to reuse, and high-end resources are difficult to coordinate, which …

Artificial Intelligence-Enabled Materials Innovation: Implementation Levels And Strategic Layout, Ziwei Zhao, Fengxiang Zhou, Yanglili Zhou, Can Wang, Pei Zhang, Weihua Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Materials innovation has long been constrained by vast design spaces, complex processing routes, lengthy validation cycles, and difficulties in engineering translation. Traditional research and development models, which mainly rely on accumulated experience, theoretical deduction, and experimental trial and error, have become increasingly insufficient to meet the demand for rapid breakthroughs in critical materials. In recent years, artificial intelligence has been increasingly integrated into materials design, synthesis, and processing, characterization, evaluation, optimization, and application feedback, promoting the transformation of materials innovation from experience-driven exploration to data-driven development and from discrete trial and error to closed-loop optimization. Based on an analysis of …

Artificial Intelligence Empowered Biological Research: Paradigm Shifts, Application Scenarios, And Strategic Layout, Xinguang Zhu, Yiming Bao, Zhenong Jin, Xin Li, Sijia Wang, Yueming Wang, Yungui Yang, Cao Xu, Yan Xiong, Bin Han

Bulletin of Chinese Academy of Sciences (Chinese Version)

Life related processes are characterized by high dimensionality and multi-scale properties. Understanding mechanisms underpinning life processes helps promote national healthcare, agricultural development, sustainable ecological civilization, and national security. Current life science research is confronted with an enormous challenge of dimensionality stemming from data explosion and data fragmentation, for which the recent rapid advancement of artificial intelligence (AI) provides novel solutions. AI will catalyze a paradigm shift in life science research from the current experiment based empirical induction to a new closed-loop knowledge acquisition including large scale data collection, model building, model prediction, experimental validation, and iterative of these procedures. Life …