Digital Commons Network^™

Chemotherapeutic Induction Of Cytosolic Single-Stranded Dna Accumulation Sensitizes Triple-Negative Breast Cancer To Immunotherapy, Yong Du, Li Yang, Hui Dai, Jianli Zhou, Zhicheng Zhou, Ruoxi Yuan, Rui Ye, Anh Thai Quynh Nguyen, Kishor Bhatia, Shiaw-Yih Lin

Faculty, Staff and Students Publications

Background: Despite the widespread adoption of chemoimmunotherapy in triple-negative breast cancer (TNBC), the mechanisms by which cytotoxic chemotherapy engages antitumor immunity remain poorly defined. Identifying tumor-intrinsic immunogenic programs that predict and enhance responsiveness to immune checkpoint blockade (ICB) is therefore of critical clinical importance.

Methods: Transcriptomic signatures of TREX1 deficiency were generated from CRISPR-engineered TNBC models and applied to multiple independent TNBC cohorts treated with chemoimmunotherapy. Cytosolic single-stranded DNA (ssDNA) accumulation was quantified using a flow cytometry-based assay to functionally screen chemotherapeutic agents. Immune activation and therapeutic efficacy were evaluated using in vitro assays, syngeneic mouse tumor models, flow cytometry, …

Modern Architecture Of Muqarnas In Damascus: An Original Computational Methodology, Nahed Jawad Chakouf

All Works

The research aimed to revive muqarnas using digital computational tools, drawing on the techniques of Damascene craftsmen and ancient manuscripts. It involved designing contemporary muqarnas with double-curvature vaults and large spans, incorporating new unit designs and compositional techniques. In Section I, the researcher conducted pre-design studies on four muqarnas types, each associated with one of the four Damascene architectural styles. These studies examined the geometry and behavior of muqarnas types when used on traditional domed surfaces. Section II included a design study of the Dome of the Eagle of the Umayyad Mosque in Damascus, using modern software tools such as …

Cervical Insufficiency Revisited: A Proposal For A New Treatment-Aligned Definition, Vincenzo Berghella, Ilaria Paladino, Moti Gulersen, Rupsa Boelig, Amanda Roman

Department of Obstetrics and Gynecology Faculty Papers

Cervical insufficiency [CI] has traditionally been defined as painless cervical dilation resulting in recurrent second-trimester pregnancy loss in the absence of labor or placental pathology. Definitions from the American College of Obstetricians and Gynecologists and the Royal College of Obstetricians and Gynecologists emphasize historical clinical presentation. However, contemporary obstetrics relies increasingly on ultrasound-based cervical length surveillance and evidence-based cerclage indications rather than retrospective diagnosis. The objective of the review was to propose a definition of cervical insufficiency aligned with current evidence-based indications for mechanical prevention of preterm birth, i.e. cervical cerclage. In modern obstetric practice, the operational diagnosis of clinically …

Ndls Communicator: Week Of 06.29.26, Notre Dame Law School

NDLS Communicator

The Latest News

• Olivia Rogers ’23 J.D. to clerk for U.S. Supreme Court Justice Amy Coney Barrett
• Notre Dame Law School Announces Faculty Promotions for Susan Azyndar and Msgr. John Paul Kimes
• ND Law’s Program on Church, State & Society Announces 2026 Writing Competition Winners
• Notre Dame Law School is Cultivating Hope

Faculty Briefs

• Paolo Carozza
• Francisco Urbina
• Mary Ellen O'Connell
• Jeff Pojanowski
• Haley Proctor
• Derek Muller
• Rick Garnett
• Ashley Sanchez
• Susan Azyndar & Yan Yu
• Carter Snead
• Emily Bremmer
• Emilia Powell
• Howard Glickstein

ND Law in the News

• Notre Dame Law School was mentioned in coverage of Indiana’s eviction …

Application Of Toast Criteria, Comorbidities And Outcomes In Patients With Ischemic Stroke: Multicenter Collaboration In The Dominican Republic, Ryna Then, Maria Muñoz, Cristina Ramos, Marcos Mota, Priscilla Sepulveda, Lisa José, Luis Suazo, Francisco Mendez, Yahaira Franco, Cosme González Villamán, Acela Gonell, Violiza Inoa, Gillian Gordon Perue, Manuel Colomé-Hidalgo, Nadja García

Einstein Health Papers

INTRODUCTION: Stroke is a leading cause of neurological-related death in the Caribbean. The Dominican Republic has among the highest stroke-related mortality rates in the Americas. We aimed to determine ischemic stroke etiologies, characterize comorbidities, and describe outcomes in the Dominican Republic using the TOAST (Trial of Org 10172 in Acute Stroke Treatment) classification.

METHODS: We analyzed a multicenter quality registry between January 2022 and October 2024. Statistical analyses included Mann–Whitney U and Kruskal–Wallis tests with Bonferroni correction, chi-square tests, and Spearman correlation.

RESULTS: The most common stroke subtype was undetermined etiology (54.8%), followed by large artery atherosclerosis (17.2%) and cardioembolism …

[Early Bird] The Texas Common Ownership Litigation: Sustainability, Competition, And The Boundaries Of Asset Manager Capitalism, Federico Ghezzi

Yearbook of Antitrust and Regulatory Studies

This article analyzes the recent attempt by the Texas Attorney General to invoke the common ownership doctrine as a new antitrust weapon against large institutional investors allegedly engaged in coordinated ESG strategies. The case represents a peculiar reversal of the traditional logic of the theory: rather than being used to constrain horizontal shareholdings that may reduce competition, common ownership is deployed here to challenge collective action aimed at promoting environmental sustainability. The paper situates this development within the broader debate on the anticompetitive effects of horizontal ownership, briefly examining the economic assumptions underlying the theory, the limits of its empirical …

Effective Strategies For Improving Communication In Organizations That Hr Leaders Use To Increase Employee Productivity, Susan Dean

Walden Dissertations and Doctoral Studies

No abstract provided.

Physical Activity Mediation In Perceived Emotional Support And Type 2 Diabetes Among African American Older Adults, Don Scott Mendes

Walden Dissertations and Doctoral Studies

No abstract provided.

Exploring Critical Limitations And The Sustainability Of Small- And Medium-Sized Enterprises, Uluocha Diamond Okojie

Walden Dissertations and Doctoral Studies

No abstract provided.

Medical Social Workers’ Knowledge Of Alzheimer’S Disease Screening And Treatment In Primary Care Settings, Amy Davis Cook

Walden Dissertations and Doctoral Studies

No abstract provided.

Temporary Blood Donor Deferrals: Analysing Their Impact On Donor Retention And Future Re-Donations, Ambreen Kashif, Rana Hasanato

Sultan Qaboos University Medical Journal

Objectives: Temporary blood donor deferral can be a challenge in retaining donors and to maintain a stable blood supply. This study aimed to analyse the pattern of temporary donor deferral and its impact on their future return for donation Methods: This retrospective study included deferred blood donors from the Blood Bank department of King Khaled University Hospital, Riyadh, Saudi Arabia, and included data from January 2021 till December 2023 with subsequent donors follow up till August 2025 were recorded .Effect of demographics, causes of temporary deferrals and gender wise distribution were compared between new and regular blood donors …

Kelelahan Kerja, Kualitas Tidur, Dan Pengetahuan Mengemudi Defensif Sebagai Faktor Risiko Perilaku Defensive Driving Pada Pengemudi Grabcar Malang, Elisa Lutfiyah Azizah, Dian Puspitaningtyas Laksana, Marji Marji, Agung Kurniawan

National Journal of Occupational Health and Safety

Online transportation activities contribute to the increasing volume of vehicles, particularly GrabCar drivers in Malang City, which has the potential to worsen traffic congestion. Identification results showed that GrabCar drivers experienced drowsiness while driving and work fatigue due to the habit of working at night and for more than eight hours per day, accompanied by limited understanding related to defensive driving. This study aimed to determine the effect of work fatigue and knowledge, as well as differences in sleep quality scores, on defensive driving behavior. This study employed an observational analytic design with a cross-sectional approach involving 87 GrabCar drivers …

Outcomes Of Patients With Higher-Risk Myelodysplastic Syndromes/Neoplasms Treated With Hypomethylating Agents + Venetoclax-An Analysis From The International Consortium For Mds (Icmds) Validate Database, Jan Philipp Bewersdorf, Geoffrey L Uy, Samuel Urrutia, Constantine N Logothetis, Et Al.

2020-Current year OA Pubs

Monotherapy with hypomethylating agents (HMA) remains the standard of care for patients with higher-risk myelodysplastic neoplasms (HR-MDS). Recently, the randomized phase III VERONA study evaluating azacitidine plus venetoclax (VEN) versus azacitidine plus placebo in newly diagnosed HR-MDS showed no difference in overall survival (OS) between the two arms. However, whether the addition of VEN to HMA improves outcomes among subsets of patients with HR-MDS remains debated. We analyzed 1907 patients with HR-MDS from 31 centers in 9 countries who were treated with HMA monotherapy or HMA/VEN in the frontline setting (HMA monotherapy: n = 1773; HMA/VEN: n = 134). Responses …

Self-Help Or Hype? How The Public Seeks And Uses Health And Self-Help Information, Bailey Fraser Dr., Joanna Pozzulo Dr., Emily Pica Dr.

Journal of Social, Behavioral, and Health Sciences

The rapid growth of the global wellness industry and increased availability of health information through social media and self-help resources have raised concerns about the public’s ability to evaluate credible health information. This study examined how adults in Canada and the United States use health information, what they consider qualifies information as evidence, and their reading behaviors related to physical and mental health, including self-help books. A total of 96 participants completed an online survey assessing health information use, criteria for evidence, reading habits, and self-help book selection. Participants reported using health information primarily to make personal health decisions and …

Development Of A Smart Solar Panel Based On Embedded Systems, Khotam Bakhtiyor Ugli Mirzokulov

Chemical Technology, Control and Management

This paper addresses the growing need for sustainable energy solutions by analyzing global solar energy trends and the barriers limiting renewable energy deployment in Uzbekistan, despite national goals such as the Strategy for Transition to a Green Economy. The research presents the design and implementation of a smart dual-axis solar tracking system based on the Arduino Uno microcontroller, integrating four LDR sensors and two servo motors to automatically align a photovoltaic panel with maximum solar radiation. A control algorithm continuously compares light intensity values, adjusts horizontal and vertical angles, and ensures safe mechanical operation. The developed prototype demonstrates improved light …

Forecasting Covid-19 New Cases Using Nbeats Deep Learning And Mobility Data, Amril Nazir, Mohammad Shorfuzzaman, Muhammad Lujaini Lotfi, Firuz Kamalov, Sufian Badawi, Maen Takruri, Abdul Halim Jallad

All Works

COVID-19 is a highly contagious disease transmitted primarily through human contact. Therefore, understanding population mobility is essential for predicting COVID-19 case trends. In this paper, we propose a novel deep learning approach for forecasting new COVID-19 cases using a neural architecture called Neural Basis Expansion Analysis for Interpretable Time Series (N-BEATS). The N-BEATS model effectively handles long input sequences and large output horizons without information loss or increased computational complexity. We compare the performance of N-BEATS with a state-of-the-art benchmark model, LSTM-Markov, across four major countries: the United States, the United Kingdom, Russia, and Brazil. Three distinct COVID-19 datasets from …

History Happenings, Georgia Southern University

History: News & Publications

No abstract provided.

Socio Ecological Theory And Apprenticeship Systems, Eoghan Murchadha, Róisín Murphy

Research Outputs: 2025-Present

Apprenticeship as a paradigm may be regarded as a system consisting of inter-related stakeholders in a relatively complex but collaborative relationship. Societal phenomena such as this are suitable for analysis through the application of the theory of socio-ecology. While such studies have been undertaken to an extent in the past, the analyzes conducted have been limited in terms of socio-ecological strata used. Furthermore, such studies have generally analyzed apprenticeship within jurisdictions where training is extensive with few social partners involved. Conversely, this study analyzes apprenticeship in the context of the standardized Irish craft model where the number of key stakeholders …

Coupled Multiphysics Transport-Reaction Modeling Framework For Combustion Synthesis Of Cement Phases: Insights Into Β-C2s Formation And Wavefront Dynamics, Sayee Srikarah Volaity, Shubham Agrawal, Aditya Kumar, Narayanan Neithalath

Materials Science and Engineering Faculty Research & Creative Works

Biofuel-based combustion synthesis (BCS) processes offer low-temperature, low-carbon routes to lime and clinker production. However, they involve tightly coupled interactions between heat transfer, gas flow, and sequential solid-state reactions within reactive pellets. Experiments typically provide surface temperature evolution and final phase assemblages but give limited insight into the conversion process and the interaction between composition and process conditions. A coupled transport-reaction framework is developed here to resolve this limitation─the synthesis of β-C2S (belite), a major cementing phase, serving as an example. Transient conservation equations for energy, momentum, and species are solved for a porous pellet exchanging heat and mass with …

Occupational Therapy’S Role And Impact In Cancer Prehabilitation: A Scoping Review, Abbey Rancour, Averi Haas, Emily Peckham, Kate Reimer, Kylie Mccaskill

Masters Projects

Background:

Oncology prehabilitation aims to optimize patients’ physical and psychosocial function before cancer treatment, yet the specific contributions of occupational therapy (OT) remain underexplored.

Objective:

This scoping review aims to map and synthesize the existing literature describing the role and reported benefits of OT within oncology prehabilitation programs.

Methodology:

Following Arksey and O’Malley’s (2005) scoping review framework and guided by the PRISMA-ScR checklist, three databases (PubMed, CINAHL, and Web of Science) were searched. Search terms included preoperative exercise, prehabilitation, neoplasms, and cancer. Articles were screened by two independent reviewers, and data were charted and analyzed descriptively and thematically.

Results:

A …

Examining The Impact Of Transformational Change To Modernize Federal Government Records, Michael Lloyd

Walden Dissertations and Doctoral Studies

No abstract provided.

Customer Engagement Strategies Among U.S. Food Service Leaders In The Postpandemic Digital Era, E'Yanna Yvette Davis

Walden Dissertations and Doctoral Studies

No abstract provided.

Review And Analasys Of Explainable Artificial Intelligence Applications In Distributed Systems And Microservices, Latafat Abbas Gardashova, Allahshukur Mirzazada

Chemical Technology, Control and Management

The widespread use of AI systems in important infrastructure, it's very important that algorithmic decision-making processes are clear and easy to understand. Explainable Artificial Intelligence (XAI) has emerged as a vital research domain addressing the opacity in contemporary machine learning models, particularly deep neural networks, which function as inscrutable black boxes. This literature review provides a comprehensive examination of XAI methodologies and their applications in distributed systems, with a particular emphasis on microservice architectures. The review compiles contemporary taxonomies of XAI methods and elucidates the fundamental strategies that facilitate the comprehension of models across various computing environments. This study also …

Mathematical Modeling And Image Processing Algorithms In Artificial Intelligence-Based Technical Vision Systems, Erkin Uljaev, Ulmasjon Ulfat Ogli Abdixalilov

Chemical Technology, Control and Management

This paper presents a comprehensive study on the development of a mathematical model and image processing algorithms for artificial intelligence-based technical vision systems. The research focuses on analyzing the structural organization and functional components of the system, including image acquisition devices, illumination subsystems, and data processing modules that ensure stable and accurate operation. A systematic and integrated approach is applied to model the transformation of object parameters and to enhance the accuracy, robustness, and reliability of object detection processes. Particular attention is given to image preprocessing, segmentation techniques, and contour detection algorithms, as these stages play a crucial role in …

Planning The Movements Of Robots Based On Intellectual Technologies, Temurbek Omonboevich Rakhimov, Dildora Usmonovna Sevinova

Chemical Technology, Control and Management

This article is devoted to the issues of planning the actions of robots based on intelligent technologies. One of the main issues in the intelligent planning of robot manipulators' movements is to determine the configuration of the links corresponding to the final position of the manipulator handle in the given Cartesian coordinate. Including the planning of robot movements based on intelligent technologies, the automation of production processes, the discretization of the space of links in the process of planning the movements of robots is important, because this space determines the possible states of the robot handle. The article considers the …

Fuzzy-System-Based Correction Of Nonlinearities In Complex Dynamic Plants, Zokhid Ergashboyevich Iskandarov, Tukhtamurod Khayitmurodovich Avezov

Chemical Technology, Control and Management

A method for synthesizing a fuzzy compensating element from the static characteristic of a nonlinear plant is presented. The method transforms the characteristic into a rotated coordinate system, identifies zero crossings and local extreme, maps the characteristic points back to the original coordinates, and uses them to determine the antecedent membership functions and singleton consequents of a zero-order Sugeno inference system. Unlike heuristic rule tuning, the proposed procedure derives the rule base directly from the geometry of the nonlinear characteristic. An adaptive reconfiguration mechanism based on a mismatch indicator is also formulated for operating conditions in which plant parameters vary …

Management Of Multi-Agent Robotic Systems Using Artificial Intelligence Technologies, A.T. Hamiyev

Chemical Technology, Control and Management

This article addresses the problem of managing multi-agent robotic systems using artificial intelligence technologies. A hybrid model combining the Vision-Language-Action (VLA) architecture with the Multi-Agent Deep Deterministic Policy Gradient (MADDPG) algorithm is proposed for the synergetic control of a group of robots. The model is built on the Centralized Training with Decentralized Execution (CTDE) principle, with a Social-Force component incorporated into the reward function to automatically maintain a safe distance between agents. Experiments were conducted in the NVIDIA Isaac Sim environment using a dataset of over 10,000 trajectories and scenarios involving 4 to 16 agents. The results show a 90% …

Modeling Of A Mechatronic Module Based On A Linear Motion Actuator, Nodira Batirdjanovna Аlimova, Bekmurod Bayotovich Yusupov

Chemical Technology, Control and Management

This article is devoted to the modeling of a mechatronic module based on linear motion actuator, including the processes of modeling the dynamic, kinematic, and control parameters of the mechatronic module, as well as the design and functional characteristics of the drives providing linear motion. In modern manufacturing enterprises and automated production systems, the need for mechatronic modules with high accuracy, speed, and reliability is increasing. In addition, mechatronic systems based on linear motion play a key role in the efficient control of technological processes, increasing positioning accuracy, and reducing energy consumption. The article presents mathematical models that allow one …

Adaptive Control And Optimization Methods In Complex Robotic Systems Using Artificial Intelligence Algorithms, Otajon Normuminovich Norboyev

Chemical Technology, Control and Management

This research addresses the critical problem of controlling complex robotic systems characterized by parametric uncertainty and external disturbances. Within the scope of this work, a novel adaptive control model was developed based on the integration of artificial intelligence elements and modern control theory. The proposed approach combines classical nonlinear control theory, Lyapunov stability analysis, and neural function approximation mechanisms into a single, unified system. The primary advantage of this model is that it does not require prior exact knowledge of system parameters and ensures high precision and energy efficiency by minimizing the control functional in real-time. Unknown system dynamics are …

Architecture Of The Information System Supporting Information Processing And Decision-Making In Medicine, Isamidin Sidikov, Sanjarbek Bekturdiev

Chemical Technology, Control and Management

This article examines the architecture of an information system that supports information processing and clinical decision-making in the field of medicine. The system is described using a multilayer functional model that enables the integration, analysis, and efficient utilization of heterogeneous data. The utilization of the BioBERT and XGBoost neural network models at data collection, preparation and analysis, as well as decision-making steps using machine learning and expert systems are summarized. The use of IDEF methodology for modeling medical information system is reviewed and the importance of IDEF0, IDEF1, IDEF1X, IDEF2, and IDEF3 models is emphasized. An efficient paradigmatic model for …