Digital Commons Network^™

Sex-Specific Regulation Of Mash And Hepatocellular Carcinoma: A Role Of Sphk2 In Females, Bria Pierre

Theses and Dissertations

Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) is characterized by excessive fat accumulation in the liver, with metabolic dysfunction-associated steatohepatitis (MASH) representing a more severe form that can progress to cirrhosis or hepatocellular carcinoma (HCC). The sphingosine kinases and the S1P signaling pathway are key regulators of MASH and HCC progression. While much is known about the mechanisms contributing to MASH-HCC in males, less is known for females. Nevertheless, we previously identified sphingosine Kinase 2 (SphK2) to protect females from MASH-driven HCC. This study first performed differential gene expression analysis on human liver cohorts to examine sex-specific differences in gene expression …

Improving Telehealth Education And Training: A Needs Assessment Of Healthcare Providers And Trainees, Conor Duffy

Theses and Dissertations

Telehealth utilization has increased dramatically since the start of the COVID-19 pandemic. There are many positive impacts of this shift to telehealth, including increasing access to care and reducing patient burden. However, healthcare providers report several consistent challenges that limit their ability to deliver telehealth, such as effective communication, technological difficulties, and difficulty performing physical examinations. To address these concerns, it is necessary to integrate telehealth education and training into healthcare professional training programs and healthcare systems. While many institutions have implemented telehealth education and training since the start of the pandemic, there is little consistency in the content, duration, …

Vol. 53, No. 2: Table Of Contents, Denver Journal Of International Law & Policy

Denver Journal of International Law & Policy

No abstract provided.

Modeling The Impacts Of The Current And Projected Temperatures On Spongy Moth Population Dynamics, Adrienne B. Spring

Theses and Dissertations

The spongy moth (Lymantria dispar) is an invasive forest pest that has caused significant ecological damage across the United States. Its invasion front is shaped by a number of factors, including temperature in both the northern and southern regions. With ongoing climate change, areas that were previously uninhabitable may become increasingly favorable for moth population establishment and expansion, while other areas may experience thermal stress limiting persistence. This study develops a temperature-driven population model to analyze how temperature affects the spongy moth population dynamics along the invasion front. This model incorporates temperature effects on fecundity, stage-specific survival rates, …

Place, Culture, And Care: A Socioecological Examination Of Type 2 Diabetes Among Hispanics In The U.S., Danielle Montoya

Theses and Dissertations

Introduction: Type 2 diabetes (T2D) disproportionately affects U.S. Hispanic populations. This dissertation examined whether structural determinants fundamentally drive T2D disparities among Hispanics, with attention to within-group racial heterogeneity.

Methods: Three studies utilized nationally representative data. Study 1 examined neighborhood segregation and ethnic enclave residence associations with T2D using restricted NHANES data (2011-2018, n=5,056). Study 2 investigated acculturation and T2D associations using restricted NHANES data (2011-2018, n=4,540). Study 3 analyzed patient-provider racial/ethnic concordance and adequate diabetes care using MEPS data (2008-2021, n=17,138).

Results: Structural factors demonstrated primacy across all studies. Neighborhood segregation (aOR=1.17, p>0.05) and ethnic enclave residence showed no …

Identity Formation Of A Pre-Service Art Educator: An Arts-Based Approach To Data Visualization As A Means Of Understanding Personal Experience, Kelsey L. Peterson Mays

Theses and Dissertations

This research centers on the emotional experience of the author as a pre-service art educator during her student teaching semester. The research utilized art-based data collection methods and analyzed both written and visual reflections over an eight-week period of teaching art at the elementary school level. The culmination of findings is synthesized in the form of a body of four visual artworks, where each work reflects the data collected over a consecutive period of two weeks. The study investigated the causation and ramifications of certain emotions during a transitional time wherein the author existed in a liminal space between student …

Predictive Inference For Ion Concentration With Machine Learning And Bayesian Methods, Alexandra B. Ulbing

Theses and Dissertations

Ultraviolet--visible (UV--Vis) spectroscopy produces high-dimensional signals that are strongly collinear, shift with concentration, and exhibit heteroskedastic, non-Gaussian noise. These features make supervised regression from spectra to ionic concentrations statistically challenging and limit the reliability of methods that assume linear structure or homoscedastic errors.

This dissertation develops two complementary frameworks for prediction and uncertainty quantification in UV--Vis spectroscopic regression: (1) frequentist stacked ensembles combined with distribution-free conformal prediction, and (2) Bayesian hierarchical modeling and Bayesian stacking. Together, they provide a unified view of model-based and distribution-free uncertainty across nickel and nickel--cobalt datasets.

The frequentist component builds ensembles of Functional Data Analysis …

Relationship Extraction Using Retrieval Augmented Generation For Biomedical Dataset, Jannat Jannat

Theses and Dissertations

With the increasing number of structured and unstructured data, obtaining reliable information effectively has become crucial. In the biomedical domain, extracting information from the scientific papers is crucial in order to stay up-to-date with accurate information, given the increased pace by which new research studies are published. This work focuses on identifying relationships between entities that are extracted from the abstracts and titles of biomedical research papers. In this work, we developed a Retrieval Augmented Generation (RAG) based system to automatically identify relations between biomedical entities. We evaluate multiple open source Large Language Models (LLMs) and the number of examples …

The Design Of A House, Lars Mattingly

Theses and Dissertations

Photography lends itself to both damaging and facilitating connection, the camera at once a weapon of destruction and a catalyst for change. The Design of a House is a call to love deeply. In the aftermath of body trauma, I use portrait photography to reconnect with myself and others. Through making portraits, I bridge my own gap between fear and intimacy. Primarily working with film-based cameras and hand-sensitized photographic materials, I reintroduce touch through process. The slowness, delicacy, and tactility of these acts offer a safety I am learning to trust. When photographing myself, my mother, and my partner, I …

A Fault-Tolerant Exchange-Coupled Spin-Ensemble Qubit At Elevated-Temperatures, Aniruddha Chakraborty

Theses and Dissertations

This thesis introduces a novel qubit architecture: the ferromagnetic exchange-coupled spin ensemble qubit (E-qubit), designed to address the noise-induced instability. In this work, the time evolution of the ensemble’s density matrix is studied using the Liouville–von Neumann equation. To benchmark against a single-spin qubit, the gate fidelity of an E-qubit is computed in the presence of thermal noise. Coherence time is also analyzed under identical thermal condition and a linear scaling is observed with qubit size . The results show that, at 6 K , the gate fidelity error (0.7 % ) of the seven- spin ensemble is an order …

Collaborative Robots For The Automation Of Additive Manufacturing Workflows, Logan Schorr

Theses and Dissertations

Collaborative robots have the potential to transform the world, being easier to program, safer around humans, and far cheaper than their industrial counterparts. This makes them uniquely qualified to operate autonomously in environments where the presence of humans is necessary, either as an operator themselves or as observers of active processes. One of the fields where collaborative robots have significant opportunity for utility is in metal additive manufacturing, in which near net-shape parts can be autonomously fabricated using materials like stainless steel, titanium, or nickel super-alloys. These processes, especially laser powder bed fusion and directed energy deposition, use a fine …

The Influence Of The Covid-19 Pandemic On Student Engagement At A Historically Black University, John C. Travis

Theses and Dissertations

This study examined student engagement across three NSSE administrations at an HBCU—pre-COVID (2018), during COVID (2019), and post-COVID (2022). Engagement was analyzed across four themes: Academic Challenge, Learning with Peers, Experiences with Faculty, and Campus Environment. Results showed that Learning with Peers declined significantly over time, with the largest drop between 2018 and 2022, reflecting pandemic-related disruptions to peer interaction. No significant year effects emerged for the other themes. Two-way MANOVAs indicated that gender, first-generation status, and major did not significantly predict engagement, nor did they interact with year. In contrast, classification emerged as the most consistent predictor, with upper-division …

Theatre As Sanctuary: Queer Identity, Religious Trauma, And The Path To Healing, Casey Worley

Theses and Dissertations

Growing up as a queer individual in a deeply religious Southern Baptist community, I learned early that faith and identity could feel like irreconcilable forces. I sat in the pews, surrounded by voices that preached love but often excluded people like me. For years, I struggled with the question: Can I be both queer and faithful? This tension—between belief and belonging, between the church I was raised in and the identity I could no longer deny—became the foundation of my journey, my artistic practice, and this thesis.

Through this research, I explore the intersections of queer identity, religious trauma, and …

Strange World, Brooklin Grantz

Theses and Dissertations

My thesis work explores the intersections of masculine and feminine labors as they relate to the structure of domestic space. I utilize materials and processes akin to craft, construction and architecture, and domicile upkeep, noting what is shared between gendered and polarized fields while exploring uses of the grid in various instances as a structure to adhere to and antagonize: a binary. Highlighting the queerness and fluidity of materials and the similarities between seemingly disparate processes, I relate to the objects I make and alter through my own gender fluidity. I do not see masculinity or femininity as autonomous: the …

Review Of Texas Rangers In The Mexican-American War, By William Fox., William C. Yancey

History Faculty Publications

No abstract provided.

Vessels Of Spirituality: Merging Faith And Form, Maryam Al-Tajer

Theses and Dissertations

According to traditional Islamic teachings, natural materials like frankincense, black sesame seeds, and sidr (jujube) leaves are valuable both physically and spiritually. Historically, they have been used for healing and purification. Nowadays, influenced by contemporary science, people tend to overlook their metaphysical value, focusing on their medicinal uses. Similarly, Muslims assign spiritual qualities to the Muqatta’at, the disconnected letters that preface several surahs of the Holy Quran, believing them to contain sacred power. In both of these cases, the material leads to the spiritual.

Through material experimentation, informed by religious texts, my thesis combines revered materials with sacred letter forms …

Genetic Epidemiology Of Chronic Wasting Disease And Epizootic Hemorrhagic Disease In North Dakota Deer, Ethan S. Baker

Theses and Dissertations

Wildlife diseases have become a critical factor in the management of animal populations across the globe. Such diseases can compromise individual health, reduce population sizes, and disrupt ecosystem biodiversity. As a result, there can be a loss in recreational opportunities which, in turn, can cause economic losses for communities relying on these populations. Effective wildlife disease management not only requires the ability to respond to outbreaks but also the capacity to predict how diseases interact with populations and ecosystems. Due to the complexity of disease dynamics, a multidisciplinary approach is essential for gaining a comprehensive understanding of these systems. In …

Assessment Of Drivers Of Light Attenuation In Virginia Reservoirs, Jackson Barnett

Theses and Dissertations

Water clarity in aquatic ecosystems is crucial for submerged vegetation and algal dynamics. We investigated the factors influencing light attenuation (kd) by measuring total suspended solids (TSS), chlorophyll-a (CHLa), and chromophoric dissolved organic matter (CDOM) across thirteen stations located in seven reservoirs. Average kd was 1.69 m^-1 (range: 0.37-3.99 m^-1), with photic depths averaging 3.27 m (range: 1.15-12.43 m). TSS was the primary predictor of light attenuation (R² = 0.57, P = 0.003, SE = 0.053). Average TSS values for each site were multiplied by the slope of the kd-TSS relationship to find the proportion of kd …

Strengthening The Health And Well-Being Of American Indian And Alaska Native Elders, Andria Begay

Theses and Dissertations

Health is a holistic concept within Indigenous communities, emphasizing the balance and interconnectedness of mind, body, and spirit. This dissertation explores the health and wellbeing of American Indian and Alaska Native Elders, with each of the products for this three-part portfolio, targeting different health matters that are often overlooked among Elders, aged 55 years and older. Using secondary data from National Resource Center on Native American Aging’s 2020-2023 cycle of the Identifying our Needs: A Survey of Elders, I conducted three quantitative research analyses with chi-square tests and binary logistic regressions to assess the association and differences in variables. Manuscript …

Subgingival Microbiomes Of Healthy And Periodontitis Subjects, Tareq Abdulrasoul

Theses and Dissertations

Background: Periodontitis is a common chronic inflammatory disease triggered by the dysbiosis of the subgingival microbiome. 16s rRNA sequencing has been used to profile the subgingival plaque samples in healthy and periodontitis subjects. Here, we have collected subgingival plaque samples from subjects and analyzed the microbiome profile from 16s rRNA sequencing. We hypothesized that periodontitis patients will have a different subgingival microbiome profile than that of healthy subjects.

Methods: Subgingival plaque samples were collected from periodontitis and healthy subjects who were indicated for periodontal surgeries (osseous resective and regenerative surgery for periodontitis patients or crown lengthening for healthy …

Rethinking Pilot Retention In The United States: An Analysis Of Key Factors, Michael James Hickey

Theses and Dissertations

This thesis examined pilot retention challenges in U.S. regional and low-cost carriers (LCCs), focusing on nonfinancial incentives such as quality of life, career stability, and work-life balance, which may have a greater influence on retention than traditional financial incentives. This quantitative, survey-based approach assesses how pilots rank the factors that influence their retention. Using a sample of U.S.-based pilots, the study examines six key areas adapted from a European pilot retention framework. Statistical analyses, including the Friedman test, the Mann-Whitney U test, and the Kruskal-Wallis test, identified correlations between demographic variables and retention priorities. The inherent financial constraints of regional …

Multiphysics Modeling Of Material Response To High-Intensity X-Ray And Laser Pulses: Heating, Ablation, And Plasma Expansion, Youssef Abouhussien

Theses and Dissertations

This dissertation presents a computational framework to investigate material response under high-intensity X-ray fluxes produced by an exo-atmospheric nuclear detonation and laser-material irradiations, with a focus on heating, ablation, and plasma expansion phenomena relevant to satellite vulnerability and high-energy-density environments. A hybrid Monte Carlo and Two-Temperature Model (MC-TTM) was developed to simulate X-ray and laser energy deposition and thermal relaxation in metals and semiconductors across a range of X-ray and laser pulse durations from femtoseconds to nanoseconds. Results demonstrate distinct thermal behavior between materials, with ablation thresholds and phase transitions captured in good agreement with experimental data.

In parallel, a …

The Trauma-To-Prison Pipeline: A Multi-Level Theoretical Framework Exploring The Intersection Of Inequality, Trauma, And Exclusionary Discipline, Dana Ainsworth

Theses and Dissertations

The school-to-prison pipeline (STPP) is a widely recognized and extensively studied metaphor used to describe the process by which school discipline policies increase the risk of juvenile justice system involvement, particularly among historically marginalized populations. While it has been instrumental in shaping educational policy, the STPP framework has not evolved to account for the critical impact of trauma on learning and behavioral outcomes. Furthermore, it overlooks the role of systemic inequality that increases trauma exposure and produces concentric patterns of marginalization.

Drawing on research across the fields of education, public health, sociology, and criminal justice, this study proposes a theoretical …

Exploring Student-Athlete Perceptions On Nil Opportunities In The Cannabinoid Industry, Katherine Klimchock

Theses and Dissertations

The introduction of Name, Image, and Likeness (NIL) regulations in collegiate athletics has created new financial and branding opportunities for student-athletes. Simultaneously, there has been an evolving legal landscape surrounding cannabinoids both at the state and National Collegiate Athletic Association (NCAA) levels. This dissertation in practice explores this emerging intersection by examining student-athlete perceptions of NIL opportunities with cannabinoid brands and highlighting the perceived advantages and disadvantages of such deals. This dissertation in practice consists of three artifacts. Artifact I provides essential background information on NIL, cannabinoids, and the House v. NCAA settlement. Recognizing the legal, institutional, and cultural shifts …

Student Participation In Informal Resolution: Examination Of Impact Factors On Recidivism And Student Perceptions Of Institutional Care And Fairness, Linnea Rose Nelson

Theses and Dissertations

This exploratory case study, conducted at the University of North Dakota (UND), examined factors influencing recidivism and student perceptions of institutional care and fairness among participants in the piloted Informal Resolution (IR) option. A restorative justice (RJ)-informed alternative to the traditional student conduct process, the IR is offered to students charged with first-time, low-level violations of UND’s code of conduct. This study aimed not only to evaluate the new process but also to respond to recent calls from scholars and practitioners for more extensive research on the intersection of RJ and student conduct outcomes. Sherman’s (1993) defiance theory provided the …

Speech-Language Pathology Graduate Programs: What Influences Students To Apply?, Emily Stephens

Theses and Dissertations

Speech-Language Pathologists (SLPs) are licensed professionals trained to work with various age ranges who have communication, feeding, and/or swallowing difficulties. The entry level education for an SLP to actively practice is a master’s degree. To fill the many vacant and needed SLP jobs across the country, it is necessary for SLP master’s programs to admit highly qualified students into their programs, resulting in many competent SLPs entering the workforce to fill the current job openings. Minot State University’s SLP master’s program has experienced a significant decline in graduate applications over the past decade. There is limited research specific to the …

Modeling Synergistic Effects Of Integrin And Tgf-Β Signaling In Epithelial Mesenchymal Transition, Prerak Thakkar

Theses and Dissertations

The induction of Epithelial Mesenchymal Transition (EMT) is initiated by a

number of protiens and growth factors, one of which is the profibrotic cytokine Trans-

forming Growth Factor β (TGF-β). Within the extracellular matrix (ECM), TGF-β

is found in a latent, inactive form bound to proteins such as fibronectin (FN). For

TGF-β to contribute to EMT induction, it has to be extracted from the latent com-

plexes into a soluble form. This soluble, activated TGF-β can then bind to receptors

on the cell membrane, which causes the transduction of signals that begin EMT. Re-

search has shown that the release …

Food Waste Renaissance: From The Table, For The Table, Yasamin Shaikhi

Theses and Dissertations

What if waste could be seen as a valuable resource rather than a burden? Food Waste Renaissance (FWR) explores innovative ways to transform excess food and byproducts into sustainable design materials. In Qatar, where food waste constitutes approximately 60% of urban waste, FWR promotes a shift in perception rather than attempting to resolve large-scale waste management issues. By fostering a culture where surplus becomes a resource, it inspires individuals, designers, and communities to embrace and contribute to a circular economy. FWR examines rice and date byproducts as biodegradable raw materials for lamps, bringing material from the table back to the …

The Bitch And The Boogeyman: Violence Against Women And Gendered Morality In American Slasher Films, Davis A. Smith

Theses and Dissertations

This research examines the relationships between on-screen depictions of violence in American slasher horror films and depictions of gendered morality of victims. Slashers are a subgenre of horror film that arose out of the exploitation cinema movement of the 1970s that are characterized primarily by the presence of one or more human killers inflicting violence on a group of protagonists, typically through the use of bladed weapons. Data collected comes from a comprehensive set of thirty-six American slasher films that received a wide theatrical release, with exemptions for films whose primary genre is not slasher and only selecting three films …

Existing In The Context: A Conjunctural Analysis Of Kamala Harris Memes, Amaya Mcneal

Theses and Dissertations

Political memes have become a common way for people to express their political views online, helping politics reach young adults who weren’t previously interested. Consequently, politicians have begun sharing and creating memes themselves. The memeification of American politics has diminished debate about ideas, ideals, issues, and people’s vital interests, debasing voters by treating them not as citizens but as passive “consumers” and “spectators” of mediated politics. This paper helps make sense of this crisis, focusing on the example of former Vice President Kamala Harris. Vice President Kamala Harris' memeified presidential campaign during the 2024 U.S. election targeted voters through a …