Digital Commons Network^™

Analysis Of Cytokine Data In A Case-Control Study Of Me/Cfs, Navya Amaratunga

Electronic Theses & Dissertations (2024 - present)

This study investigated the role of cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating multi-system disease with unknown etiology. Using data from a case-control study (60 cases, 61 controls) previously collected by Dr. Roxana Moslehi’s lab, serum levels of 48 cytokines were analyzed. Statistical analyses, including T-tests, Wilcoxon Rank Sum tests, and logistic regression (unadjusted and adjusted for medication use), were performed to identify differences between cases and controls.

Results revealed a statistically significant difference in mean Fractalkine levels between cases and controls (p=0.031). Borderline significant differences were also observed for IL-6 (p=0.046) and MIP-1α (p=0.046). Unadjusted logistic regression …

The Association Of Hyperhomocysteinemia (Hhcy) With Cancer Risk: An Updated Systematic Review And Meta-Analysis Of Case-Control Studies (2013-2024), Hajar Heidari

Electronic Theses & Dissertations (2024 - present)

Abstract:

Cancer continues to be one of the leading causes of morbidity and mortality globally, influenced by a complex interplay of genetic, environmental, and nutritional factors. Among these, the metabolism of homocysteine (HCY), a sulfur-containing amino acid derived from dietary methionine, has attracted growing attention due to its involvement in one-carbon metabolism and its potential link to cancer. Elevated HCY levels, a condition known as hyperhomocysteinemia (HHCY), have been shown to disrupt crucial cellular processes such as DNA methylation and promote oxidative stress (OS)—both of which contribute to genomic instability and cancer progression. Disruptions in the folate and methionine cycles, …

The Effects Of Mindfulness On Chronic Pain In Children And Adolescents: A Systematic Review, Sophie Parks

Electronic Theses & Dissertations (2024 - present)

Mindfulness and mindfulness-based interventions have become increasingly popular in recent years. Typically, mindfulness-based interventions and their effects on mental health and/or adult populations have been explored in the literature. Limited research has been completed looking at mindfulness’ impacts on other facets, including chronic pain symptoms. Additionally, some research has been conducted to analyze mindfulness and its effects on school aged children and their day-to-day functioning with promising results. In this systematic literature review, mindfulness interventions and their effects on children and adolescents who experience chronic pain were explored. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework was …

Weaving A Tapestry Of Community Based Child Trafficking Interventions In High-Trafficking Incidence Areas In Ghana, Crispin Mbamba

Electronic Theses & Dissertations (2024 - present)

Background: This dissertation addresses the urgent issue of child trafficking in high-incidence areas of Ghana, where sociocultural, economic, and structural factors sustain and exacerbate this complex social challenge. The rationale for the study is grounded in the need for a holistic understanding of child trafficking beyond traditional justice-based approaches. The research emphasizes the necessity of community-led interventions informed by local cultural norms and protective values that have been largely unexplored in the Ghanaian context. Specifically, this dissertation applies an integrative approach, rooted in the Ubuntu philosophy, to explore community interdependence as a central component of sustainable anti-trafficking interventions.

Methods: …

Physiological Structure, Activity, And Interactions Of The Formin, Human Diaphanous Homologue 1, Aaron Premo

Electronic Theses & Dissertations (2024 - present)

Human Diaphanous Homologue 1 (DIAPH1) is a 143 kDa functional protein that plays a critical role in the regulation of actin dynamics within eukaryotic cells. As a formin, DIAPH1 facilitates the assembly of actin filaments from globular actin monomers, a process essential for cellular structure, motility, and other fundamental cellular processes. Beyond its structural role in actin polymerization, DIAPH1 is implicated in several diseases, including diabetes, cancer, and inflammation, as well as complications like hearing loss. Despite its significance in human health, the functional and structural properties of DIAPH1, particularly in human cells, remain less explored compared to related proteins, …

Effects Of Actualized Language Policy On Ukrainian Stability, 1989-2022, Dawn Hersey

Electronic Theses & Dissertations (2024 - present)

This dissertation seeks to generate a new perspective of the complicated relationship between actualized policy and stability through looking at Ukraine’s language policies and stability in a mixed manner approach that includes both primary and secondary sources. Russia justified its irridentist activities through claiming to protect Russian nationals within Ukraine’s borders: language policies within Ukraine appear to be a trigger for Russian antagonism. Neither Russian irridentism nor Ukrainian nationalism are being considered as right or wrong in this dissertation: the intent is to highlight trends, patterns, and perceptions in alignment with Ukrainian language policy. This dissertation does not present a …

The Dynamics Of Mystical Experiences: Interaction Effects And Distinct Contributions Of Meq-30 Factors, Genevieve Falabella

Electronic Theses & Dissertations (2024 - present)

Many participants in clinical trials of psychedelic-assisted therapy (PAT) report mystical experiences. Researchers often use the 30-item Mystical Experience Questionnaire (MEQ-30) to measure mystical experiences. Several studies have validated a four-factor structure of the MEQ-30, but only as a subset of items within broader versions of the scale (e.g., MEQ-43). As such, the factor structure of the standalone MEQ-30 remains unvalidated in English. Additionally, some data suggest that certain factors might be more strongly associated with psychedelic-associated outcomes than others, which could provide insight to enhance the therapeutic potential of PAT. The aim of this study was to examine the …

Technological Development Of In-Cell Nmr: Microfluidic, Metabolomic, And Fluxomic Approaches, Nicholas Sciolino

Electronic Theses & Dissertations (2024 - present)

In the fields of structural biology, metabolomics, and fluxomics, there is a driving, technique-based concern when it comes to high-resolution spectrometry and its marriage to biological and physiological relevance. Sample preparation often involves cellular perturbation, lysate separation schemes, combinations with non-biological reagents, and timeline slack. Conceptually, the farther we get from the cell, the greater the potential disparity between what exists in vivo and our in vitro manipulations. This is particularly true when seeking to collect data on transfected targets of interest, and on sensitive metabolic equilibria that occur on the order of minutes. The question remains: if we are …

Climate Change In The Local News: The Role Of Community Characteristics In Shaping Themes And Diversity, Hyerim Jo

Electronic Theses & Dissertations (2024 - present)

Despite widespread recognition of climate change and its localized impacts, research on how local media cover this topic remains limited. The first study of this dissertation analyzes 15,788 opinion articles published from 2013 to 2020 by 391 local newspapers in the United States to examine their volume, topics, and thematic emphases. Using automated text analysis methods, including Latent Dirichlet Allocation (LDA) and Analysis of Topic Model Networks (ANTMN), the study identifies 11 topics and three overarching themes. Findings indicate that the volume, topics, and themes evolved over time, likely influenced by the severity of climate-induced hazards and political and socioeconomic …

Advancing 4h-Silicon Carbide Power Device Technology Through Improved Device Design, Performance And Reliability, Stephen A. Mancini

Electronic Theses & Dissertations (2024 - present)

The work presented in this document focuses on advancing the overall design, performance, and reliability of 4H-SiC power devices through various design architectures and processing strategies. Power devices serve as an efficient way to control the flow of power and thus are utilized throughout a vast number of different systems. These systems accommodate various current and voltage ratings to support applications such as personal electronics, electric vehicle components, fast chargers, renewable energy solutions, and energy storage systems. As the demand for these applications grows alongside global electrification and sustainability efforts, minimizing power losses becomes increasingly important. Therefore, developing efficient and …

The Impact Of A Creativity-Focused Course Design On The Development Of Pedagogical Creativity In Preservice Teachers, Joanna M. Weld

Electronic Theses & Dissertations (2024 - present)

Current preservice teachers have been apprenticed within an educational system that favors standardization which has limited their experiences with creative teaching and learning. The field of teacher education is currently lacking in frameworks to support the creative development of preservice teachers. The aim of this practitioner research, multiple-case study was to examine the impact of a creativity-focused course design on the beliefs of preservice teachers enrolled in a Secondary English Methods course in regards to the nature of creativity, the role of creativity in teaching and learning, their personal creative strengths and weaknesses, and creativity in lesson planning. Data was …

Epitaxial Quantum Dot Scintillators With Monolithic Photodetector Integration: Physics, Fabrication And Characterization Of Materials And Devices, Allan Oreave Minns

Electronic Theses & Dissertations (2024 - present)

This dissertation discloses the physics, fabrication, and characterization of high-performance scintillator detectors based on epitaxial InAs quantum dots (QDs) in GaAs. The detector crystals grown include monolithically integrated In_0.35GaAs photodetectors with Al_0.92-0.6In_0.03-0.35Ga_0.05As metamorphic buffer layers (MBL). A device fabrication process was developed for the lithographic patterning, chemical etching, contact metallization and readout integration of materials grown by means of molecular beam epitaxy (MBE) on 3-inch GaAs (001) wafers. Low capacitance integration with readout electronics was achieved through wire bonds to custom printed circuit boards (PCBs) with commercial components.

The relationship between device …

Advancing Forensic Firearm Analysis: Quantitative Measurement Of Pellet Patterns Using Open Source Software, Inez Staples

Master of Science in Forensic Science Directed Research Projects

Shotgun pellet pattern analysis plays a critical role in forensic firearm investigations, particularly for estimating muzzle-to-target distances. However, conventional methods based on pattern diameter become unreliable when only partial patterns are recovered, as is often the case in forensic scenarios involving soft tissue or incomplete impact surfaces. This study aimed to validate ImageJ, an open-source image analysis software, as a standardized, accurate, and reproducible tool for measuring pellet-to-pellet distances in partial shotgun patterns. The methodology included calibration of ImageJ using a perforated poly board, comparison of manual versus digital measurements on 17 pre-made pellet patterns, and development of a calibration …

Impact Of Substrates And Deposition Time On Bacteria Associated With Saliva Samples And Its Implication On A Bacterial Signature-Based Body Fluid Identification Method, Olisdey Galano Cruz

Master of Science in Forensic Science Directed Research Projects

Traditional serological methods for body fluid detection are limited by poor specificity and sensitivity, lacking confirmatory capability and thereby increasing the risk of false positives that may compromise the integrity of forensic investigations. While molecular methods such as mRNA, miRNA, and DNA methylation offer improved specificity, they are often hindered by marker instability and operational complexity in routine forensic workflows. Bacterial signature profiling has emerged as a promising alternative, offering enhanced stability, abundance, and compatibility with existing DNA workflows. However, its forensic implementation requires further validation. This study evaluated the effects of substrate type and storage time on the salivary …

Fast Times At Buckley High: The Assault On 1980s Nostalgia In Bret Easton Ellis’S The Shards, M. Keith Booker

English Faculty Publications and Presentations

Bret Easton Ellis, in novels such as Less Than Zero (1985) and American Psycho (1991), has vividly chronicled some of the darkest aspects of American society in the 1980s. It is thus no surprise that his return to writing about the 1980s in The Shards (2023), published amid a wave of nostalgia for the 1980s in American culture, goes strongly against that wave. The novel is set in the fall of 1981, when its narrator/protagonist—one “Bret Ellis”—is a high school senior in Los Angeles. This character (presumably a younger version of the author) goes out of his way to present …

Is The Light Triad Really That Light?: The Light Triad's Role In Relationship Savior Complex, Skylar Robinson, Gary Lewandowski

Modern Psychological Studies

Light triad traits, such as optimism, empathy, and compassion, are theorized to be three main components of a prosocial and compassionate orientation. However, in romantic relationships, those qualities may encourage a “savior complex” in which one partner attempts to help, fix, or change their partner’s less ideal components. To study this, 106 participants ranging in age from 18 to 24 years old were surveyed about their light triad traits, helping/savior complex behavior, confidence as a romantic partner (i.e., self-efficacy), closeness with their partner (i.e., inclusion of other in the self), and perceived responsiveness toward their partner. As hypothesized, those who …

More Than An Athlete: Exploring Mental Health Concerns Among Student-Athletes, Callista Rochon-Baker, Hillary Wehe

Modern Psychological Studies

Within the United States, student-athletes experience the psychological and physiological effects of collegiate sports; however, student-athletes may not feel comfortable accessing mental health care resources or there may be inadequate resources available. This study sought to assess personal and environmental deterrents to the well-being and athletic performance of collegiate athletes. Through a series of qualitative interviews with 11 student-athletes from a small, Midwestern university, researchers investigated mental health stigmas in athletics, barriers to psychological resources, and the necessity for sports psychology interventions on-campus. The interview questions focused on student athletes’ level of perceived mental health support from campus and coaches. …

Pacific Islander Mental Health: A Literature Review, Shawn I. Dobberfuhl

Modern Psychological Studies

Mental health among Pacific Islanders remains an underexplored area in research. This review aims to synthesize existing research on the mental health status of Pacific Islanders, focusing on mental health risk factors and mental health service utilization. A systematic search across APA PsychInfo spanning from 2015 to 2024 yielded 11 relevant articles, which were subsequently analyzed and synthesized. Findings suggest that Pacific Islanders experience unique stressors, including, racial discrimination, socioeconomic disparities, and cultural stigma surrounding mental health. However, there is a disparity in culturally sensitive assessment tools and interventions tailored specifically to this population. Future research should prioritize phenomenological methods, …

Study Of The Relationship Between Interoceptive Sensibility And Distress Tolerance In Community And College Samples, William W. Moore, Ashley Howell

Modern Psychological Studies

Interoceptive sensibility involves the detection, integration, and interpretation of internal bodily signals, primarily from cardiovascular, pulmonary, or gastrointestinal systems. Dysfunction in interoceptive processing has been increasingly recognized as a clinically relevant factor in numerous neurological, psychiatric, and behavioral disorders. This study aimed to elucidate the relationship between interoceptive sensibility and distress tolerance, hypothesizing that individuals with heightened interoceptive sensibility may report poorer distress tolerance. This relationship could help identify patterns between interoceptive sensibility and tendencies toward maladaptive coping strategies or emotional dysregulation. To explore these relationships, two studies were conducted utilizing self-report measures of interoceptive sensibility and distress tolerance in …

Born To Be Kind: The Evolutionary Significance Of Prosocial Behaviors In Humans, Yijia Xu

Modern Psychological Studies

Humans prefer kind romantic partners. Worldwide surveys have identified kindness as the defining feature of an ideal long-term partner, often explained as a signal for evolutionary fitness, demonstrating the ability to provide resources and ensure survival. Instead, we propose an alternative explanation: human preference for prosociality stems from an innate desire to be treated well. To test this, we asked participants whether they preferred kindness directed towards them or kindness exhibited more generally. Results indicate that participants were significantly more attracted to people who were kind to them personally than to people who were broadly kind to others. Interestingly, participants …

Escapism: The Presence Of Escapist Tendencies In Depressed Gamers, Hannah K. Weberg, Emily Pica

Modern Psychological Studies

Escapism, a coping mechanism used to relieve stress, uniquely characterized by removing one’s conscious self from reality, can be utilized by video gamers with depression to escape from their own realities. The implications of this phenomenon could allow researchers to better understand how escapism affects this community. It was predicted that there would be a positive relationship between escapist gaming motivations and depressive symptoms. Using a combination of quantitative and qualitative survey methods drawing from undergraduate students at Austin Peay State University (n = 113) and correlational analyses, our hypotheses were supported. A significant positive relationship was found between escapist …

The Influence Of Media Exposure On Perceptions Of Police, Izabella Leblanc, Emily Pica

Modern Psychological Studies

The current literature suggests that People of Color (POC) often hold more negative perceptions of law enforcement compared to White individuals. These perceptions are influenced by various factors, including environment, exposure to media depictions of police brutality, and personal experiences. Since flawed portrayals of police procedures in television programs have been found to erode public trust in police legitimacy, the study analyzes how perceptions change through media portrayals of law enforcement interactions. We investigate how the media influences perceptions of law enforcement by presenting participants (n = 245) with mock news articles depicting various law enforcement interactions. Additionally, we consider …

Pathways To Lgbtq+ Self-Acceptance: A Qualitative Study Of Religious, Spiritual, And Mystical Experiences, Makayla Hall, Ruth Walker

Modern Psychological Studies

For the LGBTQ+ community, self-acceptance often involves embracing one’s identity while confronting internalized stigma, hardships, and religious or societal pressures (Lassiter et al., 2019; Schuck & Liddle, 2001; Stern & Wright, 2017). Prior researchers have highlighted both positive and negative effects of religious and spiritual beliefs for LGBTQ+ individuals, with spirituality often fostering resilience and social support (Lassiter et al., 2019) and religious institutions sometimes contributing to feelings of alienation (Schuck & Liddle, 2001). The purpose of this study was to explore how religious, spiritual, and mystical experiences influence self-acceptance in LGBTQ+ adults. We used reflexive thematic analysis to explore …

Atherogenic Lipoproteins Associate With Loss Of Glycemic Control In Youth-Onset Type 2 Diabetes: Results From The Today Study, Lorraine E Levitt Katz, Samuel S Gidding, James D Otvos, Kimberly L Drews, Fida Bacha, Steven Willi, Santica Marcovina, Siripoom Mckay, Ruth S Weinstock, Today Study Group

Faculty, Staff and Students Publications

Background: Type 2 diabetes (T2D) in adolescents is associated with an unfavorable lipid profile, but lipoprotein particle subspecies and branched-chain amino acid (BCAA) data are scarce.

Objective: To evaluate lipoprotein particle distributions, lipoprotein insulin resistance index (LP-IR), and BCAA levels longitudinally and their relationships with sex, race/ethnicity, treatment, and loss of glycemic control in adolescents with youth-onset T2D.

Methods: Participants from the TODAY study (n = 348) had samples analyzed yearly for glycated hemoglobin and nuclear magnetic resonance lipoprotein and BCAA assessments.

Results: At baseline, participants with T2D were 13.7 years old with T2D, obesity, and from racial and ethnic …

Central Obesity Is An Independent Determinant Of Advanced Fibrosis In Lean Patients With Nonalcoholic Fatty Liver Disease, Arka De, Naveen Bhagat, Manu Mehta, Priya Singh, Sahaj Rathi, Nipun Verma, Sunil Taneja, Madhumita Premkumar, Ajay Duseja

Faculty, Staff and Students Publications

Background: The current definition of lean is based on body mass index (BMI). However, BMI is an imperfect surrogate for adiposity and provides no information on central obesity (CO). Hence, we explored the differences in clinical profile and liver disease severity in lean patients with nonalcoholic fatty liver disease (NAFLD) with and without CO.

Methods: One hundred seventy lean patients with NAFLD (BMI < 23 kg/m2) were divided into two groups depending upon the presence or absence of CO (waist circumference ≥80 cm in females and ≥90 cm in males). Noninvasive assessment of steatosis was done by ultrasound and controlled attenuation parameter (CAP), while fibrosis was assessed with FIB-4 and liver stiffness measurement (LSM). FibroScan-AST (FAST) score was used for non-invasive prediction of NASH with significant fibrosis.

Results: Of 170 patients with lean NAFLD, 96 (56.5%) had CO. Female gender (40.6% vs. 17.6%, P = 0.001), hypertriglyceridemia (58.3% vs. 39.2%, P = 0.01) and metabolic syndrome (23.9% vs. 4.1%, P < 0.001) were more common in the CO group. There was a poor correlation between BMI and waist circumference (r = 0.24, 95% CI: 0.09-0.38). Grade 2-3 steatosis on ultrasound was significantly more common in CO patients (30% vs. 12.3%, P = 0.007). CAP …

Testosterone Plus Lifestyle Therapy Improves Skeletal Muscle Glycolysis In Older Men With Obesity And Hypogonadism, Viola Viola, Marlene Aguilar, Maria Liza Duremdes Nava, Alessandra Celli, Reina Armamento-Villareal, Yoann Barnouin, Nicola Napoli, Nagireeddy Putluri, Clifford Qualls, Dennis T Villareal

Faculty, Staff and Students Publications

Objective: Weight loss in older men with obesity and hypogonadism accelerates musculoskeletal decline, yet the underlying metabolic mechanisms remain unclear. Testosterone replacement therapy (TRT), when added to lifestyle therapy (LT), mitigates this decline, but its metabolic basis has not been defined. We examined skeletal muscle metabolomic adaptations to LT with or without TRT, focusing on glycolysis, the pentose phosphate pathway (PPP), the tricarboxylic acid (TCA) cycle, and carnitine metabolism to identify dominant pathways of metabolic adaptation.

Design: Randomized, double-blind, placebo-controlled trial (LITROS).

Methods: Eighty-three men aged 65 years or older with obesity (BMI ≥30 kg/m2), hypogonadism (testosterone < 10.4 nmol/L), and frailty (Physical Performance Test score ≤31) were randomized to 26 weeks of LT plus TRT (LT+TRT) or LT plus placebo (LT+Pbo). A metabolomic substudy was performed in 44 participants, who underwent serial biopsies of the vastus lateralis for targeted LC-MS/MS analysis of intermediates in glycolysis, PPP, TCA cycle, and carnitine metabolism.

Results: Among the …

Sodium-Glucose Cotransporter-2 Inhibitor And Glucagon-Like Peptide-1 Receptor Agonist Discontinuation In Patients With Ckd, L Parker Gregg, Peter A Richardson, Vijay Nambi, Laura A Petersen, Michael E Matheny, Salim S Virani, Sankar D Navaneethan

Faculty, Staff and Students Publications

Key Points:

1. Treatment discontinuation is common among patients with CKD prescribed sodium-glucose cotransporter-2 (SGLT2) inhibitors (discontinued in 37%) or glucagon-like peptide-1 receptor agonists (GLP-1 RA; discontinued in 47%).

2. Discontinuation of SGLT2 inhibitors and GLP-1 RA was associated with recent hospitalizations, Black race, Hispanic ethnicity, and vascular disease.

3. Discontinuation of both agents was associated with death and cardiovascular events.

Background: Little is known about the association of discontinuation of sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RA) with outcomes in patients with CKD.

Methods: We identified adults with CKD stages 3–4 from 2005 to 2022 in the Veterans …

Prognostic Value Of Soluble Cd200 Concentration In Chronic Lymphocytic Leukemia And Its Correlation With Clinical And Laboratory Parameters, Dhuha Fakhri, Israa Mohamed Baqir

Iraqi Postgraduate Medical Journal

Background: Chronic lymphocytic leukemia (CLL) is a malignancy of mature B-lymphocytes characterized by their accumulation in the bone marrow and peripheral blood. CD200 is an immune checkpoint molecule critical for immune tolerance, and its overexpression has been associated with tumor progression through immune evasion mechanisms, particularly via interaction with CD200R. Aims of the Study: To assess plasma levels of soluble CD200 (sCD200) in newly diagnosed CLL patients compared to healthy individuals. To correlate sCD200 levels with disease stage, hematological parameters, and prognostic markers: β2-Microglobulin (β2M) and Leukocyte Associated Immunoglobulin-like Receptor-1 (LAIR-1). Methods: This cross-sectional study was conducted over six months …

The Effectiveness Of Hepatitis B Virus Vaccine In End Stage Renal Disease Patients On Hemodialysis, Ali Alwan, Zaid Ali, Harith Hadi

Iraqi Postgraduate Medical Journal

Background: Immunization is the most effective way to prevent transmission of hepatitis B virus and hence the development of acute or chronic hepatitis B. End stage renal diseases (ESRD) patients have lower seroconversion rates compared with the subjects with intact renal function. Moreover, even after the completion of hepatitis B vaccination schedule , anti-HBs titer of responders was found to be low and decline logarithmically with time.Study objectives: this study is to identify the effectiveness of Hepatitis B vaccine and its response in end stage renal disease patients on hemodialysis. Patients and methods: A cross sectional study with analytic components …

Patriarch Kirill Of Moscow And All Russia: A True Patriarch Or A False One, A Senior Cleric Or A Senior Politician Of The Russian Federation? The Russian Patriarch And The War In Ukraine, Dilyan Nikolchev

Occasional Papers on Religion in Eastern Europe

This paper focuses on the behavior of the current Russian Orthodox Patriarch Kirill (Gundyaev) in the context of the Russia’s military aggression against sovereign Ukraine – a religious leader who fully supports the war policy of the Kremlin. The pro-war and pro-Putin views and messages of Patriarch Kirill proved him in the eyes of the Orthodox world more as a false Patriarch and a politician than as the primate of the Russian Orthodox Church. To a large extent, the Russian political narratives and ideology of the “Russian Peace” and “Holy Rus” doctrine are a product of the senior leadership of …