Digital Commons Network^™

Life Satisfaction In Justice-Involved Opioid Users, Cassandra Michel

Public Health Theses

Life satisfaction—an individual’s overall evaluation of their life, including their feelings and attitudes toward it—has been linked to a range of psychological and physical health outcomes. While numerous studies have examined the factors associated with life satisfaction across various populations, such as healthy young and older adults, limited research has focused on individuals with substance use disorders or those involved in the criminal justice system. This study explored the relationship between psychosocial and structural factors and life satisfaction among justice-involved individuals with a history of opioid use disorder. Using cross-sectional survey data from a sample of 372 participants, I conducted …

Influenza Vaccine Coverage, Effectiveness, And Disease Burden Among Pediatric Sickle Cell Patients In Connecticut From 2021-2024: A Test-Negative Case-Control Study, Precious Nchekwube

Public Health Theses

Background: Vaccination is the primary strategy to reduce influenza burden. Limited data exist on the burden of influenza, vaccine coverage, and seasonal influenza vaccine effectiveness (VE) in children and adolescents with sickle cell disease (SCD).

Aim: To evaluate influenza vaccine coverage, effectiveness, and disease burden among pediatric and adolescent patients living with SCD for the 2021-2024 influenza seasons in Connecticut, USA.

Methods: This was a retrospective, test-negative case-control study to estimate influenza VE against laboratory-confirmed influenza infections among children 6 months to 21 years of age across 2021-2022, 2022-2023, and 2023-2024 influenza seasons (August 1, 2021, to July 31, 2024) …

Insights Into Medical Surveillance Among Engineered Stone Countertop Workers In The United States Of America, Tony Huy Nguyen

Public Health Theses

Background: An alarming rise in the number of cases of silicosis, a progressive and incurable lung disease, among engineered stone (ES) workers has prompted concern about the extent of the problem in the U.S. and whether ES can be used safely. Overexposure to high levels of respirable crystalline silica (RCS) during fabrication or installation of ES can increase the risk of developing a more severe case of silicosis. Medical surveillance studies on US ES workers are limited.Aim: The overall objective of this study was to better understand the state of medical surveillance for ES workers using employer surveys and employee …

Characterizing The Genetic Diversity Of Pfrh5 In Plasmodium Falciparum Clinical Isolates From Burkina Faso, Ghana, And Tanzania: A Next-Generation Sequencing Study To Inform Blood-Stage Malaria Vaccine Development, Manuel Emilio Perez

Public Health Theses

The development of a highly effective malaria vaccine is of global health priority, given the persistently high malaria burden in Sub-Saharan Africa (SSA) and growing resistance to antimalarial treatment and vector control measures. P. falciparum reticulocyte-binding protein homolog 5 (PfRH5) has emerged as a leading target among blood-stage malaria vaccine candidates due to its essential role in erythrocyte invasion and initial documentation of limited polymorphisms. However, recent studies have revealed greater PfRH5 genetic diversity than previously believed, raising concerns about potential parasite evasion of vaccine-induced immunity. This study utilized deep targeted amplicon next-generation sequencing to characterize PfRH5 genetic variation in …

From Success To Setbacks: A Case Study Of The Sex Wrap And The Impact Of Instagram's Evolving Policies On Sexual Health Education, Megan Piller

Public Health Theses

Due to the inconsistent and noncomprehensive nature of sexual health education across the United States, many adolescents and emerging adults are turning to digital platforms, specifically social media, for necessary information. The Sex Wrap (TSW), a podcast and Instagram-focused intervention, was established to fill critical knowledge gaps among these populations and empower them in their sexual decision-making. To serve as a case study, engagement metrics from TSW’s Instagram account between October 2020 and September 2021 were analyzed to determine which post types, tones, and thematic categories resonated most with users across the platform. However, Instagram, once a highly effective tool …

Liver Epigenetic Changes In Mice Exposed To 1,4-Dioxane In The Drinking Water: Implications For 1,4-Dioxane Liver Carcinogenicity, Shuya Qiao

Public Health Theses

1,4-Dioxane, a probable human carcinogen and widespread environmental contaminant, has been consistently associated with liver tumor development in rodents. However, limited research has addressed its role in epigenetic dysregulation. This study investigated epigenetic alterations in liver tissue following chronic exposure to 1,4-dioxane. Male mice of wild-type (WT) and glutamate-cysteine ligase modifier subunit knockout (Gclm-KO) genotypes were exposed to 0, 50, or 500 ppm of 1,4-dioxane in drinking water for six months. qPCR, Western blotting, and immunohistochemistry (IHC) were used to assess changes in DNA methylation-related enzyme gene expression, histone acetylation, and SAM (S-adenosylmethionine) distribution. qPCR results showed significant downregulation of …

Effectiveness Of Wolbachia Introgression On Dengue Incidence In A Complex Urban Environment, Karthika Satyanarayanan

Public Health Theses

Dengue is an arboviral disease of increasing global public health importance for which more than half the world’s population is at risk. The burden of dengue has increased greatly in the last decade; in 2024, over 14 million cases and 10,000 dengue-related deaths were reported, marking a historical milestone. The endosymbiotic bacterium Wolbachia (wMel strain) offers a promising alternative to traditional control methods through its reduction of Aedes aegypti vector competence and introgression into wild Ae. aegypti populations. This thesis evaluated the dynamics of Wolbachia introgression and its effect on reducing dengue incidence up to 31 months after the completion …

Impact Of Pcv10 On Pediatric Pneumonia In Nepal, Katie Steimel

Public Health Theses

Pneumococcal conjugate vaccines have significantly reduced pneumonia cases, hospitalizations, and deaths worldwide. This study evaluates the impact of 10-valent pneumococcal conjugate vaccine (PCV10) eligibility on pediatric pneumonia hospitalizations in Nepal using administrative hospital data from three major geographically and administratively diverse hospitals. A controlled interrupted time series design was used comparing pneumonia hospitalizations with diarrhea hospitalizations, under the assumption that PCV10 would not influence diarrhea hospitalization rates. A secondary model stratified hospitalizations by age group, assessing differential trends based on vaccine eligibility. Generalized linear models with quasipoisson distributions were used, adjusting for hospital and seasonality.The primary model comparing pneumonia to …

Disparities In Clinical Trial Representation: Bioethical & Human Rights Violations Against The Global Burden Of Disease And Gender Equity, Kaustubha Reddy

Public Health Theses

This investigative thesis seeks to contribute to the understanding of how disparities in the planning, design, and placement of clinical trials perpetuate global health inequities. It will analyze the misalignment between the global burden of disease and research priorities, examining the systemic factors that determine which diseases are prioritized for trials. It will highlight the bioethical and human rights implications of gender exclusion, particularly the underrepresentation of women with HIV, in clinical research. By addressing both the upstream determinants of clinical trial planning and the downstream consequences of exclusionary practices, this work offers a comprehensive critique of the structural inequities …

Under-Five Malaria And Malnutrition Syndemic In Rajasthan, Nandini Sinha

Public Health Theses

Background: The syndemic of severe acute malnutrition (SAM) and malaria in under-five children in Rajasthan presents a critical public health challenge. Current SAM and malaria programs are implemented as siloed interventions despite the potential benefits of integrated approaches. A better understanding of the interactions between these factors is important to strengthen the delivery of integrated services.

Objective: This study investigates the relationship between under-five SAM and malaria infections at the block level in Rajasthan to inform targeted, integrated interventions. By running regression analysis, we will identify associations between these co-occurring health threats to guide state-level policy integration. To the best …

Mental Health Stigma As A Barrier To Mental Health Care For Black Youth & Young Adults: A Scoping Review, Sanaa Amaya Walker

Public Health Theses

Mental health stigma presents a significant barrier to mental health care access for Black youth and young adults, contributing to disparities in mental health service utilization in Black communities. This scoping review examines the current literature on mental health stigma as a barrier to care within Black communities, with specific focus on experiences of young Black people aged 25 and under. Review of twelve studies revealed multidimensional stigma manifestations: intrapersonal (characterized by self-reliance tendencies, shame, and secrecy), interpersonal (influenced by peer and caregiver attitudes), and structural manifestations of stigma, and stigma interventions. The findings highlight critical gaps in existing research …

Expanding The Trypanosoma Brucei Parasite Detection Limit Through Tb177 Gene Detection In Qpcr, Yi Yan

Public Health Theses

Trypanosomiasis, caused by protozoan parasites of the Trypanosoma genus, remains a significant health and veterinary burden in sub-Saharan Africa, with Human African Trypanosomiasis (HAT) and Animal African Trypanosomiasis (AAT) posing ongoing threats to underserved populations. Despite advances in therapeutics, the lack of sensitive and scalable diagnostic tools continues to limit early detection, effective disease management, and evaluation of emerging vaccine candidates. Current diagnostic methods such as light microscopy and serological tests frequently fail to detect low levels of parasitemia during the early stages of infection, thereby delaying intervention and increasing the risk of disease progression and transmission.

Our study mainly …

Colorblind Racial Attitudes Mediates The Association Between The Internalization Of Model Minority Myth Attitudes And Tolerance, Talal Ali

Senior Honors Theses and Projects

The model minority myth is the belief that Asian Americans are generally more intelligent and more hardworking than other minority groups. Many studies have demonstrated the relationship between belief in the model minority myth and anti-Black sentiment in White Americans. However, there is little literature on the relationship between belief in the model minority myth and anti-Black sentiment in Asian Americans. With this in mind, we plan to determine whether the internalization of the model minority myth in Asian Americans has a relationship with anti- Black sentiment. This relationship is being measured by the IM-4 Scale (which measures the internalization …

Pilot Study: Development Of A Food Delay-Discounting Measure For Individuals With Neurodevelopmental Conditions, Aaron Daniel Schwieterman

Senior Honors Theses and Projects

Individuals with intellectual (NDD) and neurodevelopmental (NDD) conditions experience disproportionately higher rates of obesity (Hsieh et al., 2014; Ptomey et al., 2020). Yet their diet decision-making process has been left out of the current literature. Delay discounting, which reflects the decrease in the subjective value of a reward as the delay to its receipt increases, has been linked to obesity and unhealthy food intake in typically developing adults. However, most existing tasks rely on hypothetical rewards and verbal reasoning, which limit their use with individuals who have cognitive or communication differences. The present pilot study developed and evaluated a novel …

Fairness-Aware And Culturally Adaptive Machine Learning For Predicting Adolescent Substance Use, Stephanie Nworgu

Senior Honors Theses and Projects

Early initiation of substance use during adolescence poses significant risks to long-term health, educational attainment, and social outcomes, making early identification a critical public health priority. Machine learning models have increasingly been used to predict substance use risk; however, many such models do not explicitly examine whether predictive performance differs across demographic groups. This senior project examines the fairness of logistic regression models used to predict first-time alcohol use among adolescents. Using nationally representative survey data from the Youth Risk Behavior Surveillance System (YRBSS), pooled across the 2017, 2019, 2021, and 2023 survey cycles, this study develops logistic regression–based predictive …

A Comprehensive Study Of Energy, Exergy, Exergoeconomic, And Exergoenvironment Analysis Of Combined Cycle Power Plant, Ahmed Sarhan Abdulsitar, Arkan Fawzi Saeed, Hatem Hasan Ismaeel

Babylonian Journal of Mechanical Engineering

One of the most effective ways to generate electricity in the thermal power plant is with a Combined Cycle Power Plant (CCPP), which uses both gas and steam turbines to their full potential. This research employs energy, exergy, exergoeconomic, and exergoenvironmental analyses to assess the CCPP performance. Energy analysis indicates the plant's overall efficiency, while exergy analysis identifies losses due to system irreversibilities and proposes methods for enhancement. Exergoeconomic analysis, which integrates thermodynamic and economic factors, quantifies the financial impact of exergy losses and identifies cost-effective improvement strategies. Reducing emissions of pollutants and greenhouse gases is possible through the use …

The Role Of Leptin In The Regulation Of The Soluble Amyloid Precursor Protein Alpha (Sappa) Levels In Non-Small Cell Lunch Cancer (Nsclc) Cell Media, Benjamin Haddad

Senior Honors Theses and Projects

We previously found that the levels of soluble amyloid precursor protein α (sAPPα) are partly regulated by acetylcholinesterase (AChE) in human non-small cell lung cancer cell lines A549 (p53 wild-type) and H1299 (p53-null). In this study, we hypothesize that sAPPα is partly regulated by leptin, a hormone classically recognized for its anorexigenic role in appetite regulation— yet recently shown to play a role in cancer cell signaling. It was observed that cells treated with leptin exhibited greater concentrations of sAPPα and lower concentrations of Aβ40/42 in the media compared to those of cells left untreated. An opposite effect was observed …

A Review Of Infrared Thermography Applications For Civil Infrastructure, Prabal Shrestha, Onur Avci, Sahabeddin Rifai, Feras Abla, Michael Seek, Karl Barth, Udaya Halabe

Engineering Technology Faculty Publications

Civil infrastructure is continuously subject to aging and deterioration due to multiple factors, which lead to a decline in performance and impact structural health. Accumulated damage on structures increases operational costs and poses significant risks to public safety. Effective maintenance, repair, and rehabilitation strategies are needed to ensure civil infrastructure’s overall safety and reliability. Non-Destructive Evaluation (NDE) methods are utilized to assess latent damage and provide decision-makers with real-time information for mitigating hazards. Within the last decade, there has been a significant increase in the research and development of innovative NDE techniques to improve data processing and promote efficient and …

Evaluating The Effectiveness Of Stay-In-Place Forms To Improve The Tosional Stability Of Box Beam Bridges During Erection, Karl E. Barth, Michael W. Seek, Gregory K. Michaelson, Dimitra Pyrialakou, Brook T. Woldegabriel

Engineering Technology Faculty Publications

Cold-formed tub girders provide an effective steel solution for short-span bridges. The girders are often delivered with an open top with stay-in-place forms installed on site. Walkways may be installed to the side of the girder that can induce significant torsion rotations in the open cross section. Full scale tests on girder specimens have shown that installing one or two panels of stay in place forms at the ends of the girder can significantly reduce the torsion rotation of the girder by providing warping resistance. Cantilever tests on the stay in place forms are performed to investigate the influence of …

Social Media, Populism, And Militant Democracy: An Argument For A Change In First Amendment Doctrine, Arvid Kerschnitzki

Chapman Law Review

The First Amendment is often hailed as the cornerstone of American self-government, but the digital age has transformed the public discourse it was meant to protect. Social media platforms, once envisioned as a modern marketplace of ideas, now amplify misinformation, entrench echo chambers, and enable mass manipulation, threatening the democratic ideal of an informed citizenry.

While the current First Amendment doctrine rightly emphasizes the importance of public discourse, that discourse must be inclusive, rational, and reliable to serve its democratic function. Drawing on the concept of militant democracy, this Article argues that contemporary doctrine has lost sight of free speech’s …

A Wall Of Smoke: Understanding The Drivers Of The June 2023 Canadian Wildfire Smoke Event For New York City, Gregory S. Randazzo

Dissertations and Theses

The 2023 Canadian wildfire season was notable for its extent and the dense smoke it produced. Motivated by the resulting air quality impacts in the New York City region, we explore how the total particulate matter output from the Quebec fires influenced PM2.5 concentrations downstream in New York City. Using injection height data from the Regional Advanced Baseline Imager + VIIRS Emissions dataset, we relate the tropospheric injection heights of the fires with the broader synoptic context and surface PM2.5 concentrations. Using data from the NYS Mesonet Profiler Network, radiosondes, and ERA5 reanalysis, we document the connection between an anomalous …

Using Trace Gas Measurements As A Transport Diagnostic For Tropical Convection: A Combined Model And Observation Study, Albane Hoxha

Dissertations and Theses

No abstract provided.

Peacekeeping In Sierra Leone And Mali, Ishaka Kondeh

Dissertations and Theses

This thesis examines the effectiveness of peacekeeping missions in promoting democracy, protecting human rights, and implementing Disarmament, Demobilization, and Reintegration (DDR) programs in post-conflict Sierra Leone and Mali. By analyzing the United Nations Mission in Sierra Leone (UNAMSIL) and the United Nations Multidimensional Integrated Stabilization Mission in Mali (MINUSMA), this research explores the impact of these missions on Mali still in conflict and long-term peacebuilding. The study focuses on three critical areas: supporting democratic governance, ensuring human rights protections, and successfully reintegrating former combatants into society. Through a comparative approach, this research analyzes why some peacekeeping missions succeed and then …

Examining Drug Policy In Portugal And Greece, Collin Fernandes

Dissertations and Theses

This thesis examines the divergent drug policies implemented in Portugal and Greece, analyzing why Portugal's comprehensive decriminalization model has been more successful than Greece's partial approach. Since 2001, Portugal has pioneered a drug policy that decriminalizes all drugs for personal use while investing in harm reduction services, rehabilitation, and social reintegration. In contrast, Greece maintained criminalization while implementing more limited harm reduction measures, particularly through OKANA (the Organization Against Drugs). The research highlights how economic factors, particularly the 2008 financial crisis and austerity measures, negatively affected both countries' programs but hit Greece's initiatives with greater severity. Portugal's programs have remained …

Soviet-American Relations During The Cold War: What Policies And Circumstances Conspired To Unravel The Soviet Empire?, John W. Krey

Dissertations and Theses

The two victorious superpowers of World War II – America and the Soviet Union – conceived and implemented unilateral foreign policies amid an atmosphere of intense hostility and suspicion of each other’s international intentions. Regardless of Moscow’s acquiescence in joining the United Nations and resolving a host of disputes (for example, the Security Council veto) regarding the establishment and operation of the same organization, it threatened to disequilibrate power relations between the US and the Soviet Union in the immediate aftermath of the second world war, which convinced Washington to develop the containment policy, a defensive realist posture for repelling …

Beyond The Threshold Of Protection: Examining Non-Refoulement's Erosion In Contemporary Refugee Law Through The Eu-Turkey Agreement, Aya Osman

Dissertations and Theses

This thesis examines the contemporary relevance and practical implementation of the principle of non-refoulement as established in the 1951 Refugee Convention. While this fundamental principle of international refugee law prohibits the return of individuals to countries where they face persecution, torture, or human rights violations, its widespread violation by state parties raises critical questions about its continued effectiveness and the broader validity of the Convention's framework in today's global context. Through a methodological approach combining legal analysis and case studies of state practices, this paper investigates whether the 1951 framework remains valid and in effect when addressing refugee and immigration …

The Rise Of China: Economic Expansion, Military Modification And The Belt And Road Initiative, Felix Padilla

Dissertations and Theses

In order to analyze China’s rise in power, we have to examine how China has achieved this growth. We need to observe their domestic reforms, international initiatives like the Belt and Road Initiative (BRI), and strategic military advancements. This thesis focuses on China’s economic integration, market reforms and military modernization. The thesis uncovers the effects of this rise on global governance and power balances, especially in trade, security, and geopolitics. I analyze China's vision of a multipolar world and how it contrasts with the current global order and how this fuels rivalry with the U.S. and other powers. China's rise …

The Transformative Power Of An Ethic Of Care In Patricia Piccinini’S Mythic Posthuman Offspring, Keely Parrish

Dissertations and Theses

This thesis examines the contemporary artist Patricia Piccinini and her posthuman hybrid creations within the context of a feminist ethic of care. Largely referring to scholarship by the political scientist Joan C. Tronto, I argue that Piccinini expands the definition of an ethic of care to include non-human entities as well as human ones. The four phases of care identified by Tronto will serve to outline the encounter between the audience and Piccinini’s work to see how humans and non-humans (1) care about, (2) take care of, (3) give care and (4) receive care from each other, as well as …

Living By The Sword: Religiosity And The Terrorist Subculture Of Russian Revolutionaries, 1904-1910, Gregory I. Mcevoy

Dissertations and Theses

The Marxist dictum of “religion is the opiate of the masses” has led to a prevailing assumption in scholarship that the socialist movements of the early twentieth century have been inherently atheistic. Religion is often associated as a remnant of old, antiquated society and incompatible with the claimed modernity of socialist progress. This assumption has led to overlooking the religiosity within certain radical movements and revolutionary culture at large. Scholarship on the political underground in Tsarist Russia has, thus far, perpetuated this impression. While it is the true that the Bolsheviks and Leninist Social Democrats rejected religion as obscurantist and …

Posters, Propaganda, & Bloody Saturdays: Making China Christian: How Media & Missionaries Made China Christian, Kristy Lee

Dissertations and Theses

This thesis investigates the role of religious groups and media in influencing the public perception of Chiang Kai-shek and the Kuomintang during the Second Sino-Japanese War.