Digital Commons Network^™

Mapping Dna Methylation Signatures To Identify Epigenetic Variation Across Subcortical Regions Of The Human Posttraumatic Stress Disorder Brain, Hongyu Li, Yujing Liu, Yiming Shi, Jiawei Wang, Tuan P Nguyen, Yuhan Xie, Wangjie Zheng, Youshu Cheng, Dianne A Cruz, Jennifer L Modliszewski, Rosemarie Terwilliger, Alexa-Nicole Sliby, José Jaime Martínez-Magaña, Janitza L Montalvo-Ortiz, John D Roache, Lynnette A Averill, Stacey Young-Mccaughan, Paulo R Shiroma, Bertrand R Huber, David A Lewis, Jill Glausier, Paul Holtzheimer, Matthew J Friedman, Jing Zhang, Alan L Peterson, Chadi G Abdallah, Amir Valizadeh, Xinyu Zhang, Ke Xu, John H Krystal, Ronald S Duman, Hongyu Zhao, David L Corcoran, Douglas E Williamson, Matthew J Girgenti

Staff and Researcher Publications

Background: Posttraumatic stress disorder (PTSD) is a mental disorder that may occur in the aftermath of severe psychological trauma. Epigenetic changes in the brain may play a critical role in understanding the neurobiology of PTSD by linking environmental traumatic stress exposure to lasting alterations in gene expression that shape neuronal function.

Methods: We examined 1,065,750 DNA methylation (DNAm) sites from 171 donors including neurotypical controls and PTSD and major depressive disorder (MDD) cases across 6 regions implicated in the fear circuitry of the brain. We performed RNA sequencing (RNA-seq) to examine changes in gene expression and linked these changes to …

Antibiotic Administration After Previable Preterm Prelabor Rupture Of Membranes Is Associated With Prolonged Latency, Alexandra L Hammerquist, Alexander M Saucedo, Selina L Bowler, Mohan Pammi, Catherine Eppes, Ignatia Van Den Veyver, Michael D Jochum, Enrico R Barrozo

Duncan NRI Faculty and Staff Publications

Introduction: While antibiotics have been shown to increase the interval to delivery between rupture of membranes and delivery (latency) and improve neonatal outcomes after viable preterm prelabor rupture of membranes (PPROM), this has not been well investigated in the previable PPROM population. We aimed to investigate the association between antenatal antibiotics and latency following previable PPROM. Secondarily, we examined various maternal and neonatal outcomes. We hypothesized that the administration of antibiotics would prolong latency in pregnancies with previable PPROM.

Methods: Single-center retrospective cohort study that included pregnancies diagnosed with previable PPROM between 140/7 and 216/7 and delivered between 2012 and …

Understanding The Experiences Of Faculty Members Who Teach Case Conceptualization, Asianna Harris

Dissertations (1934 -)

Competence in case conceptualization (CC) is a core skill in clinical training. However, many graduate programs lack a structured process for teaching this complex and dynamic clinical skill. While most research focuses on students’ perspectives on learning CC, there is a distinct gap in research on faculty experiences, successful teaching methods, and the assessment of teaching practices. Therefore, this study addressed the gap in extant literature by exploring how doctoral programs’ faculty taught transtheoretical CC and how they evaluated the effectiveness of their instruction. A Consensual Qualitative Research (CQR) design was employed to deeply examine the experiences of 13 faculty …

Carrying The Midwife’S Bag Across The Atlantic: German Midwives And Paraprofessional Midwifery In The Us, 1850s-1920s, Melanie Simone Lorenz

Dissertations (1934 -)

This dissertation compares the occupational development of midwifery in the United States and Germany between the 1850s and the 1920s. It examines how midwifery in nineteenth-century Germany developed into an early paraprofession through its inclusion in the paramedical division of labor and the creation of professional associations and a trade journal. In the United States, by contrast, such a development did not occur. Instead, physicians excluded midwives from the emerging paramedical division of labor. Even though a dedicated group of German American physicians and midwives attempted to replicate the German model of midwifery in St. Louis, Missouri, this paraprofessional form …

Coping With Uncertainty In Everyday Situations (Cues©): The U.S. Pilot Study, Sarah Lehman

Dissertations (1934 -)

Autistic youth experience anxiety at an increased rate compared to their neurotypical counterparts. The presence of anxiety often amplifies the social and functional difficulties faced by autistic youth, which can exacerbate poor outcomes. Intolerance of uncertainty (IU), defined as negative beliefs and reactions to unpredictable or ambiguous situations, has been identified as a key factor to the manifestation of anxiety in autistic populations. The current study aimed to replicate the protocol and results from Rodgers et al. (2023) by conducting the first U.S. pilot study examining the feasibility and efficacy of Coping with Uncertainty in Everyday Situations (CUES©); an 8-week …

Beyond The Catalog: Library Professionals' Adoption Of Ai And Ai Tools Through The Lens Of Utaut, Dr. Sankar P, Anjaline R

Library Philosophy and Practice (e-journal)

The exponential growth of Artificial Intelligence (AI) technology has radically changed the information landscape, making it essential to explore how library professionals perceive and utilize these new tools. This study examines attitudes of library professionals toward AI and AI-based tools through the lens of the Unified Theory of Acceptance and Use of Technology (UTAUT). A structured questionnaire survey was conducted amongst 165 library professionals from academic, public and special libraries spread across India. The study applies Structural Equation modeling (SEM) with the use of AMOS 26.0 to analyze the relationships among UTAUT constructs such as Performance Expectancy (PE), Effort Expectancy …

Managing Risks Under Nuclear Power Plant Projects: A Latent Similarity-Guided Contract Customization, Mariam Elazhary, Islam H. El-Adaway

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Global energy is transforming, with nuclear power emerging as a pivotal player in achieving sustainable and low-carbon energy goals. The nature of nuclear technology introduces unique challenges, such as stringent safety and environmental requirements. Existing studies focus on general risk identification, such as supply chain delays, cost overruns, and public perception issues. However, these studies fail to address integrating these risks into tailored contractual provisions, which are critical for navigating the unique challenges of nuclear projects. The goal of this paper is to examine how standard construction contracts can be tailored to better accommodate the risks inherent in nuclear power …

How Does Competitive Adsorption Between Vma And Pce Influence Yield Stress Of Cement Paste? A Novel Insight From Interparticle Forces And Percolation Threshold, Huamin Sun, Le Teng, Xiaohan Yu, Xin Shu, Zhangli Hu, Jiaping Liu, Kamal H. Khayat

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Viscosity modifying admixture (VMA) and polycarboxylate superplasticizer (PCE) are often combined to optimize rheological properties of cement-based materials. However, the competitive adsorption of these complex admixtures can greatly influence rheological properties. Many studies have investigated the variation of yield stress due to competitive adsorption between VMA and PCE; but the mechanisms are not fully understood. This study aims to shed a new light on this question in cement paste systems prepared with low water-to-binder ratios of 0.16–0.30. The competitive adsorption of VMA and PCE was quantitatively assessed using the Total Organic Carbon and Ultraviolet-Visible Spectroscopy measurements. The effect of competitive …

Digital Twin-Assisted Optimization Of 6g Wireless Networks: Ensuring Deterministic Communication, Yingpu Nian, Bo Yi, Xingwei Wang, Sajal K. Das

Computer Science Faculty Research & Creative Works

With the rapid advancement of 6G technology and the increasing use of smart devices, Deterministic 6G Wireless Networks (D6WN) have emerged to meet the growing network transmission demands. In particular, applications such as autonomous vehicles, remote surgery, and industrial automation require extremely low transmission latency to function effectively, highlighting the critical need for D6WN in supporting these time-sensitive use cases. Yet, the conventional TCP/IP framework lacks effective unified traffic and congestion control scheduling, aggravating latency and uncertainty, posing a challenge to ensuring reliable real-time critical applications. To address the challenges of deterministic transmission in D6WN, this paper integrates Digital Twin …

The Power And Peril Of Awe In Leadership: Transforming Follower Identity And Behavior, Jack Mcguire, Daniel Mcallister, Jochen Menges, David De Cremer

Research Collection Lee Kong Chian School Of Business

Awe is a profound emotion that has captured significant attention within psychological research. While the potential for leaders to inspire awe in followers has received some recognition, systematic research on the nature and effects of awe in leadership—and within organizational contexts more broadly—remains limited. In this article, we offer a conceptual framework that explains the multifaceted and transformative nature of leadership through the power of awe. Specifically, we identify four leader behaviors—charismatic leadership tactics, exceptional performance, problem reframing, and self-sacrificial behavior—that elicit awe among followers. We further propose three variants of awe-inspiring leaders, describing how variation in a leader’s self-construal …

Investigation Into Molecular Bases Of Pregnancy-Associated Malaria, Nicole Pozo

Biochemistry and Molecular Biology

Plasmodium falciparum causes the most severe and deadly form of malaria and remains a major global health problem, especially in sub-Saharan Africa (Milner, 2018). The parasite infects and multiplies inside red blood cells, leading to fever, anemia, organ damage, and death if untreated (Milner, 2018; Song et al., 2022). It is especially dangerous because it avoids the immune system by changing surface proteins called Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which are encoded by more than 60 var genes. By switching between these genes, the parasite hides from immune detection and creates repeated waves of infection (Deitsch & Dzikowski, …

Oerfsj Faculty Confidence Survey, Oerfsj

OERFSJ Templates & Resources

Template for assessing faculty confidence in evaluating, adapting, creating, and assessing the classroom use of OER. Questions will cover three categories: 

• Find and Evaluate OER  
• Adapt and Create OER 
• Assessment 

Color Shift: A Graphic Design Process Book Exploring How Color And Motion Influence Emotional Perception And Brand Connection In Affordable Women's Fashion Jewelry, Elizabeth Voight

Theses

This study examines how manipulating color and motion within a single brand identity system influences consumer emotional response and brand consistency. Using a fictional modern jewelry brand, Quanta & Co., the research isolates color as the primary variable by applying nine distinct mid-range color palettes to identical layouts, logos, and structures across both print and digital touchpoints. These collateral assets include jewelry packaging, vehicle wraps, digital advertisements, and an animated logo. A quantitative survey was executed to capture real-time audience impressions regarding brand traits, perceived quality, and the overall alignment of each color variation with the brand's identity.

The findings …

Universal Injunctions And The Executive-Judicial Relationship In America, Jeremy Kang

Senior Honors Theses

This thesis examines a specific type of legal controversy surrounding the Trump administration’s dealings with the judicial branch. Central to the matter is the concept of universal injunctions: how a federal court can enjoin even non-parties to a case from behaving in certain ways.

The history of universal injunctions, from pre-Enlightenment England to modern America, is initially discussed. Then special attention is given to their use against President Donald Trump in particular, culminating in the Supreme Court curtailing them, and district court judges ignoring the high court’s ruling. Finally, previous examples of conflict between the American executive and judicial branches …

Analysis Of Physicians Who Trained And Remain At Lehigh Valley Healthnetwork, Partof Jefferson Health: Factors Influencing Satisfaction And Retention, Michela Biondi, Terri Vian, Joseph E. Patruno Md

Research Scholars

No abstract provided.

Efficacy Of Volume-Based Enteral Feeding Compared With Standard Rate-Based Enteral Feeding, Tashia Stevens Rn, Kelly St Jean Rn, Darah Thomas Rn

Nurse Residency

Is volume-based enteral feeding more effective than standard rate-based enteral feeding in achieving nutritional goals and improving clinical outcomes in critically ill patients?

Fall Prevention, Alicia Frasier Rn, Paige Sperry Rn, Heather Tozier Rn

Nurse Residency

In elderly patients (P), does education of fall prevention (I) compared to bed/chair alarms (C) reduce falls.

The Implementation Of Q2 Turns Compared To Air Mattresses For Hapi Prevention In Adult Medical Surgical Patients Over The Course Of Their Stay, Elizabeth Mchugo Rn, Lily Fifield Rn

Nurse Residency

How does the implementation of q 2 turns compare to air mattresses for preventing HAPIs in adult medical surgical patients over the course of their stay?

Acute Intermittent Hypoxia And Acute Intermittent Hypercapnic Hypoxia Elicit Cortico-Diaphragmatic Plasticity In People With Chronic Spinal Cord Injury, Alysha Bogard, Michela Mir, Tommy Sutor, Jessica Dunn, Kathryn Cavka, Arian Vistamehr, Hannah Snyder, Joseph Welch, Jayakrishnan Nair, Gina Brunetti, Gordon Mitchell, Emily Fox

Department of Physical Therapy Faculty Papers

Respiratory impairment is a leading cause of morbidity and mortality after spinal cord injury (SCI), highlighting the need for interventions that improve breathing function. In people with SCI, acute intermittent hypoxia (AIH) elicits respiratory motor plasticity and improves inspiratory function. However, in uninjured people facilitation of corticospinal diaphragm motor evoked potential (MEP) amplitude occurs only when AIH is combined with mild hypercapnia (acute intermittent hypercapnic hypoxia; AIHH). It remains unclear whether AIHH similarly enhances diaphragm corticospinal excitability after SCI. We tested the hypothesis that AIHH increases diaphragm MEP amplitude and reduces MEP onset latency in individuals with chronic SCI, whereas …

Cerebrovascular Risk With Calcitonin Gene-Related Peptide Monoclonal Antibodies Versus Onabotulinumtoxina In Patients With Migraine: A Real-World Pharmacoepidemiologic Study In The National Institutes Of Health All Of Us Research Program, Sedat Gül, Bradley Ong, Stephen Trudeau, Nicolas Thompson, Hsiangkuo Yuan

Department of Jefferson Headache Center Papers and Presentations

AimTo evaluate whether initiation of calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) was non-inferior to initiation of onabotulinumtoxinA with respect to the hazard of ischemic stroke or transient ischemic attack (IS + TIA) in a real-world cohort of adults with migraine.MethodsWe conducted a retrospective, active-comparator, new-user pharmacoepidemiology study using the NIH All of Us Research Program Registered Tier Dataset (v8). Adults with migraine initiating CGRP mAbs (erenumab, fremanezumab, galcanezumab, eptinezumab) were compared with initiators of onabotulinumtoxinA from January 2018 through September 2023. The primary outcome was IS + TIA occurring more than 90 days after treatment initiation. Inverse probability of …

Assessing Natural Lighting In Historic School Buildings In Algeria: A Simulation-Based Design Perspective, Nesma Fercha, Akila Benbouaziz, Djamel Alkama

Iraqi Journal of Architecture and Planning

This study evaluates daylighting performance in a primary school classroom in Ain M'lila, Algeria, combining field measurements with advanced simulation. A representative classroom was modeled in DIVA-for-Rhino using accurate geometric, material, and climatic data. Illuminance measurements were taken on 28 March 2022 at 09:30, 11:30, and 14:30, and the results were compared with simulation results. The comparison showed good agreement, with minor discrepancies in shaded areas, confirming model reliability through mean squared error (MSE) and root mean squared error (RMSE) analyses. Five design scenarios were tested to enhance daylight performance by varying glazing type, louvre geometry, and surface reflectance. Spatial …

The Effect Of Morphological Transformations On The Emergence Of Complex Urban Systems: The Historical Karkh Urban Systems In Baghdad Is A Ase Study, Sara Abdul Aalie Rasheed, Wahda Shuker Al-Hinkawi

Iraqi Journal of Architecture and Planning

Cities emerge as multi-component urban systems that exhibit complexity and synergy and are shaped by morphological transformations in their structural composition. From here, the research idea was launched to demonstrate the role of morphological transformations in the emergence of urban systems with multiple characteristics and their integration to form the complex urban system. The research aims to demonstrate the impact of transformations on the emergence of the complex urban system, a fundamental characteristic of the city's growth and development, which comprises different urban structures that arise over time. The research adopted a qualitative descriptive-analytical approach and applied it to a …

Metaphysics Of Parallel Heritage In The Formulation Of The Contemporary Cityscape, Ban Mohammed Sultan, Abbas Ali Hamza Al Greiza

Iraqi Journal of Architecture and Planning

In the contemporary globalized world, the metaphysical texts of parallel heritage play a vital role in preserving the identity and privacy of cities with historical cores by conveying both the authenticity of the past and the spirit of the age in architectural production. The research problem addresses a cognitive deficiency in reading the metaphysics of parallel heritage within the urban landscape of Haifa Street, proposing it as a text that mediates between heritage and contemporaneity. The research hypothesizes that these metaphysical texts contain a creative core that functions as a future-oriented cognitive model. Using a descriptive–analytical approach, the study analyzes …

Spatial Integration, Human Density, And Land-Use Dynamics In Traditional Urban Areas: A Space Syntax Analysis Of Old Rusafa, Baghdad, Aya F. Alobaydi, Dhirgham Alobaydi, Sally F. Abdullah

Iraqi Journal of Architecture and Planning

Urban morphology is a key aspect in the development of socially sustainable environments, especially in traditional areas, whereby it is directly related to cultural identity. `Old Rusafa' is a traditional area where this investigation will be implemented. It addresses issues of population density and land-use transformation. The research aims to address a research gap by quantitatively evaluating the interrelationships among spatial configuration, human density, and land-use heterogeneity in heritage-based settings. The study is methodologically based on the application of Space Syntax (DepthmapX and QGIS) and statistical analysis using SPSS. Integrated values were calculated at the global (R = n) and …

Interpretable Machine Learning Of Plasma Proteomics Reveals Stage-Specific Signatures Across The Alzheimer's Disease Continuum, Hemshankar Laugi

2026 Spring Honors Capstones Projects

Alzheimer’s pathology begins years before clinical symptoms, starting early with amyloid-β accumulation, followed by tau deposition and neurodegeneration. Although existing tools, such as cerebrospinal fluid (CSF) screening and PET/MRI imaging, can accurately track disease progression, they are invasive, expensive, and not scalable for population-level screening. So, there is a growing interest in using blood-based plasma biomarkers as a scalable alternative. While recent studies demonstrate strong predictive performance with plasma biomarkers, most rely on a small set of canonical blood-based protein biomarkers such as amyloid-β, p-tau, and neurofilament light. These biomarkers primarily reflect downstream brain pathology and may fail to capture …

Pearson Syndrome: Expanding The Clinical Spectrum Of A Mitochondrial Cytopathy-A Case Report, Alizah Faisal, Hooria Waqas, Hania Masood, Armeen Butt, Saad Rahman, Muhammad Sheraz Hameed, Syed Rafay Hussain Zaidi, Ali Iqbal, Muhammad Usama Naveed

Department of Medicine Faculty Papers

BACKGROUND: Pearson syndrome (PS) is a rare multisystem mitochondrial disorder characterized by single large-scale mitochondrial DNA deletions (SLSMDs). It typically presents in infancy with refractory sideroblastic anemia, exocrine pancreatic insufficiency, and failure to thrive. Due to its heterogeneous manifestations and resemblance to other hematological conditions, early diagnosis remains a clinical challenge.

CASE PRESENTATION: A south asian male infant presented with persistent pancytopenia, severe anemia unresponsive to intravenous and oral iron and multivitamin supplements, exocrine pancreatic insufficiency, failure to thrive, and metabolic acidosis. Born to consanguineous parents, the child had a significant family history of early infant deaths and hematological abnormalities. …

When Neighborhoods Change, So Do Schools: Gentrification’S Influence On Public Education, Diego Ramirez

Theses and Dissertations from DePaul University

Neighborhood change is a common feature in urban life; however, gentrification is a distinct form of urban transformation characterized by rising property values, reinvestment, and shifts in neighborhood socioeconomic makeup. This literature review investigates the mechanisms through which gentrification reshapes public education and argues that gentrification has a direct impact on public schools, as these institutions reflect the socioeconomic communities around them. As neighborhoods gentrify and class demographics shift, education systems struggle to meet the demands of changing student populations, leading to unequal educational experiences. Specifically, this literature review demonstrates how gentrification reshapes public education through changes in school enrollment, …

Shsp Dean's Newsletter, Summer 2026, Brian J. Nickerson

SHSP Dean’s Newsletter

No abstract provided.

What’S Kept, Caitlin Smith

Theses

This thesis examines the collective psychological aftermath of de-industrialization in a rust belt city, processed through perspectives of nostalgia and betrayal. By reframing childhood memories of instability and inherited narratives, a framework is established for investigating the modalities through which love and attachment may obscure entangled harm, and how grief operates across both collective and personal registers. Found objects are situated as sites of projection where memories are abstracted and reconstituted. The processes of decay and weathering serve as analogues for psychological trauma, reframing deterioration as an inevitable and generative condition. Natural elements act as metaphors for neutrality, challenging imposed …

The Risk-Assessment Case For Worldwide Public Health Regulation Of The Concussion Crisis In Sports, Marcus Moore, Charles H. Tator

All Faculty Publications

The support of the medical profession was indispensable in the USA and Canada to enacting legislation addressing public health issues such as drunk driving, smoking, and bicycle helmets. The sports concussion crisis is a major public health concern in Canada and in many other countries.