Digital Commons Network^™

Aberrant Stat Signaling And T Cell Dysregulation Define A Targetable Pediatric Sepsis Endotype, Robert B. Lindell, Samir U. Sayed, Jose S. Campos Duran, Sydney A. Sheetz, Apoorva Babu, Montana S. Knight, Andrea A. Mauracher, Ceire A. Hay, Peyton E. Conrey, Julie C. Fitzgerald, Nadir Yehya, Stephen T. Famularo, Teresa Arroyo, Richard Tustin, Hossein Fazelinia, Edward M. Behrens, David T. Teachey, Lisa R. Forbes Satter, Alexandra F. Freeman, Jenna Re Bergerson, Steven M. Holland, Jennifer W. Leiding, Scott L. Weiss, Mark W. Hall, Deanne M. Taylor, Rui Feng, E. John Wherry, Nuala J. Meyer, Sarah E. Henrickson

Department of Pediatrics Faculty Papers

BACKGROUNDSepsis is a leading cause of morbidity and mortality in critically ill children, yet heterogeneous immune responses complicate the development of targeted therapies and the host immune factors driving sepsis pathobiology remain unclear.METHODSWe integrated deep immune phenotyping, plasma proteomics, single-cell transcriptomics, and phosphoflow cytometry in a prospective cohort of 88 critically ill children to elucidate the mechanisms underlying immune heterogeneity.RESULTSUnsupervised clustering of plasma cytokines identified 3 immunologic subgroups, including a high-severity group ("Group C") characterized by hypercytokinemia driven by IL-6 and IFN-γ. Group C exhibited distinct alterations in immune cell frequency and activation, with a strong association between hyperinflammatory cytokine …

How Does An Advanced Educator Utilize Digital Language Teaching And Learning By Integrating Linguistic, Cultural, And Business Life Perspectives?, Hely Westerholm, Pirjo Takanen-Körperich, Ph.D.

International Journal for Business Education

This paper explores advanced educators’ digital working capabilities in online language teaching, with a particular focus on sharing Finnish language and culture in a foreign context. Cultural and linguistic knowledge play a significant role in enhancing students’ motivation to study foreign languages. In today’s educational environment, digitalisation and globalisation exert an increasing influence on foreign language teaching and learning.

The digital learning environment has brought about a paradigm shift in foreign language didactics. Digital language learning is both challenging and holistic in nature. Continued foreign language learning is simultaneously an individual and a social process, as digital learning cultures impose …

Investigating H-Alpha Variability In Classical Be Stars: Β Lyr, 59 Cyg, And Γ Cas, Vinny Barnes, Josh Uriu, James Dull

Idaho Conference on Undergraduate Research

Classical Be stars are hot, luminous B-type stars characterized by hydrogen emission lines in their spectra. Among the most rapidly rotating stars known, they spin at 70-80% of their critical velocity, ejecting material into a circumstellar disk that produces these spectral features. Depending on viewing orientation, this can appear as either strong emission or sharp absorption lines. Be star variability arises from several sources, including disk instabilities, extreme rotation, and gravitational interactions with binary companions. To better understand this variability—and more broadly, hot star evolution—we obtained high-resolution H-alpha spectra of three known variable Be stars: 59 Cyg, OT Gem, and …

Seasonal Affective Disorder’S Prevalence And Impact On Organizational Outcomes In The Northeastern United States, Tommaso Bruce Fernandes

Walden Dissertations and Doctoral Studies

Seasonal affective disorder (SAD), a type of depression linked to seasonal changes, primarily affects individuals during fall and winter. More insight was needed on the prevalence of SAD and the role of social support in moderating its impact on organizational outcomes. The purpose of this study was to examine the relationships between SAD and organizational outcomes, including employee well-being, absenteeism, job satisfaction, and productivity, in the Northeastern United States, where SAD symptoms are more prevalent due to environmental factors. Engel’s biopsychosocial model and Cullen’s social support theory provided a theoretical framework for the study. A quantitative cross-sectional design, featuring structured …

Phonological Adaptation Of English Loanwords In Omani Arabic, Ali Algryani

Khazar Journal of Humanities and Social Sciences

Lexical borrowing is a widespread linguistic phenomenon within world languages. Loanwords undergo adaptation processes to become fully integrated into the borrowing language. This study investigates the phonological adaptation processes of English loanwords in Omani Arabic at the segmental and suprasegmental levels. The study is based on the analysis of a corpus of 100 English loanwords that were collected using data elicitation techniques. The findings show that English loanwords undergo various phonological adaptation processes at the segmental and suprasegmental levels in the integration process. At the segmental level, it seems evident that the phonemes that are not part of the phonemic …

A Corpus-Based Topic Modelling And Discourse Analysis Of Pakistan-Russia Diplomatic Discourses, Muhammad Afzaal, Ahmed Bux Jamali, Syedah Nobia Zehra, Abida Kausar Chaudhary

Khazar Journal of Humanities and Social Sciences

This study explores the underlying themes and trends embedded in the diplomatic discourses of Pakistan and Russia by employing the KeyATM approach. It also identifies and compares the linguistic strategies employed to (re)shape bilateral ties between these states. The corpus of the study comprises press releases taken from the official websites of Pakistan and Russia from 2009 to 2024. The findings reveal how discourse patterns mirror geopolitical shifts, reflecting mutual interests and shared challenges while negotiating historical legacies. This research not only contributes to the understanding of Pakistan-Russia relations but also demonstrates the efficacy of KeyATM in analyzing complex, multi-dimensional …

Correlation Between Voice Handicap Index-10 Score And Auditory Perceptual Evaluation In Lebanese And Iraqi Patients: Impact Of Cultural Disparity, Abdul-Latif Hamdan, Zeina Maria Semaan, Omar Aboul Hosn, Jonathan Abou Chaar, Maher Kasti, Batoul Jaber

Iraqi National Journal of Medicine

Background: Voice disorders are prevalent, impacting nearly 25% of adults, with even higher rates among who rely on their voices professionally. Contributing factors include smoking, poor vocal hygiene, and environmental conditions. These factors can disrupt laryngeal biomechanics, leading to functional and structural voice disorders, which can cause communication issues and diminished productivity. Evaluation methods encompass subjective evaluations, such as self-reported quality of life scales, alongside objective auditory perceptual evaluations. This study aims to establish a correlation between self-reported vocal handicap and perceptual voice evaluation, while also investigating the influence of cultural factors on auditory perceptual evaluation, specifically comparing Lebanese …

Role Of Ultrasound-Guided Percutaneous Catheter Drainage In The Management Of Infected Acute Pancreatic Necrosis, Wasam A. Al-Asadi, Bahaa K. Al-Neama

Iraqi National Journal of Medicine

Background: Acute necrotizing pancreatitis is often complicated by pancreatic collections. Symptomatic collections typically require intervention, with drainage options including percutaneous, endoscopic, and surgical techniques. Aim: This study aims to assess the therapeutic efficacy and safety of ultrasound-guided percutaneous catheter drainage (PCD) in the management of infected pancreatic collections associated with necrotizing pancreatitis. Methods: A randomized prospective study was conducted at a tertiary center between August 2020 and April 2022. Thirty-one patients with acute necrotizing pancreatitis were enrolled and randomly assigned to either ultrasound-guided PCD (n = 20) or primary surgical necrosectomy (n = 11). Outcomes were compared …

Clinical Outcomes And Technical Consideration In Transcatheter Closure Of Ventricular Septal Defect Closure, Khalid A. Khalid, Musaab H. Almaliki, Hala Hussam Naser

Iraqi National Journal of Medicine

Background: Ventricular septal defect (VSD) is the most common congenital heart disease, with an estimated incidence of 2–6 per 1,000 live births. Aim: To evaluate the effectiveness and safety of percutaneous transcatheter closure of VSD using different occlusion devices in a resource-limited, real-world setting. Methods: A retrospective single-center study was conducted at Basra Specialized Cardiac Hospital, Iraq, including patients who underwent percutaneous transcatheter VSD closure between August 2020 and August 2024. A total of 87 patients with various VSD types were enrolled. Procedural success, immediate and follow-up residual shunt, and procedure-related complications were assessed. Results: Transcatheter …

Unilateral Soft Palate Paralysis, Vitorino Modesto Dos Santos, Kin Modesto Sugai, Rafael Campos Nunes

Iraqi National Journal of Medicine

No abstract provided.

Perception Of Substance Addiction Among Medical Students Of Al-Zahraa College Of Medicine In Basrah, 2023, Jhood Abdul Samad Molan, Ziyad Tariq Maki, Anfal Mohammed, Fatima Hani Jaber, Noor Alhuda Abdul Wahab, Noor Alhuda Hameed, Noor Riyadh

Iraqi National Journal of Medicine

Background: Substance abuse is a persistent global problem. It can have multiple effects on behavioral and cognitive functions and may lead to psychological symptoms. This global epidemic not only harms individual health but also adversely affects the psychological and moral well-being of society. The prevalence of substance abuse is increasing worldwide, with a more rapid rise in developing countries. Youth constitutes the primary population at risk for substance abuse in each country. Aim: The study aimed to assess substance use-related literacy among the second and fifth-year students of Al-Zahraa College of Medicine in Basrah. Methods: This study included 158 second- …

Socioeconomic Status, Nutritional Risk, And Glycemic Outcomes In The Diabetes Population At Al-Diwaniyah Teaching Hospital, Iraq, Huda Abdulsattar Mazeal

Iraqi National Journal of Medicine

Background: Diabetes mellitus, encompassing both type 1 and type 2, represents a significant global health burden. Socioeconomic status (SES), nutritional risk, and glycemic outcomes are interrelated determinants of disease management. Aim: This study aims to examine the relationship between SES, nutritional risk, and glycemic outcomes among diabetic patients at Al-Diwaniyah Teaching Hospital, Iraq. By analyzing demographic, clinical, and nutritional characteristics, the research seeks to identify predictors of poor nutritional status and uncontrolled glycemia to inform targeted interventions and health policy. Methods: A descriptive cross-sectional study was conducted in October 2025 at the Diabetes Center, Al-Diwaniyah Teaching Hospital, …

Acute Portal Vein Thrombosis In Β -Thalassemia Intermedia: A Case Report, Rawshan Zuhair Jaber

Iraqi National Journal of Medicine

Background: Portal vein thrombosis (PVT) is a serious complication that may occur post-splenectomy in patients with β -thalassemia intermedia. This complication is particularly prevalent among individuals with iron overload and protein C and S deficiencies. Diagnostic investigations for PVT include blood tests and imaging assessments, such as abdominal Doppler ultrasound and computed tomography (CT). Advanced imaging techniques are crucial for the diagnosis and management of PVT, with improved outcomes associated with early anticoagulant therapy. Surgical thrombectomy is rarely recommended in such cases. The prognosis for PVT in patients who are not cirrhotic and do not have cancer is favorable, with …

Nasal Cockroach: A Rare Cause Of Nasal Foreign Body In A Healthy Adult Female—A Case Report, Wael J. Alshihaby

Iraqi National Journal of Medicine

Background: Nasal foreign bodies are commonly encountered in pediatric patients but are relatively rare in adults. The presence of a live insect as nasal foreign bodies is an unusual occurrence that can cause significant discomfort. This report describes the case of a cockroach lodged in the right nasal cavity of an otherwise healthy adult female that was successfully removed endoscopically. Case Presentation: A 46-year-old otherwise healthy female presented with right-sided nasal discomfort and persistent rhinorrhea of two days' duration. She reported a sensation of an insect entering her right nostril but was unable to identify the insect. Nasal endoscopy revealed …

The Role Of Mental Health In Postoperative Complications: A Literature Review, Kayla Monet Alwahhamy, Abbas Rasoul Alwahhamy

Iraqi National Journal of Medicine

Background: Currently, it is not standard practice to screen all surgical patients both pre- and postoperatively for either a prior history of mental health disorders (MHD) or active symptoms of MHD at the time of surgery. This is despite growing evidence that MHDs may impact wound healing and are recognized as a mortality risk factor in many patients. Aim: This review aims to evaluate existing literature examining mental health (MH) in surgical patients, assess whether there is a relationship between MHDs and postoperative complication rates, and determine whether outcomes differ based on the timing of MHD manifestation (pre- …

Knowledge, Attitude, And Practice Of Hepatitis B Vaccination Among Medical Students At The University Of Sulaimani, Bushra M. Ali Bajalani, Danya Nadhim Mohammed, Shoxan Othman Mohammed, Lanya Chalak Abas

Iraqi National Journal of Medicine

Background: Hepatitis B virus (HBV) infection is a major global public health and is risk factor for liver cancer. HBV spreads through contact with infected blood or semen, from infected mothers to, through sexual contact, and via unsafe medical practices such as injections, dialysis, and blood transfusions. Aim: to assess knowledge, attitude and practice of medical students regarding hepatitis B vaccine in association with colleges. Methods: A cross-sectional study was conducted to December among undergraduate medical students from three the University of Sulaimani, Iraq. A self-administered questionnaire was distributed. Data were collectedentered into Microsoft analyzed using the Statistical Package …

Antimicrobial Susceptibility And Prevalence Of Multidrug-Resistant Klebsiella Pneumoniae In Pediatric Patients In Karbala, Iraq: A Two-Year Retrospective Study, Hussein Abd Ali Mohammed Sadeq Al Her, Al-Shalah Al-Shalah, Saif A.J. Abdulrahman, Ekhlas Abdulameer Hameed Alazzawi, Noor Hussein Abdulrahman

Iraqi National Journal of Medicine

Background: Klebsiella pneumoniae is a major pediatric pathogen causing infections such as urinary tract infections, pneumonia, neonatal sepsis, and meningitis, with heightened risk in children due to immune immaturity and hospital exposure. Aim: This study aimed to retrospectively analyze the prevalence and patterns of antibiotic resistance in Klebsiella pneumoniae isolated from various clinical samples in pediatric cases at Karbala Children's Hospital from January 1, 2022 to December 31, 2023. Methods: This retrospective study examined 68 pediatric K. pneumoniae infection cases at Karbala Children's Hospital in Iraq from 2022 to 2023. Clinical samples, patient demographics, and antibiotic susceptibility were …

Anoxia Tolerant Dna Replication Is Supported By Atr Kinase In The Annual Killifish Austrofundulus Limnaeus, Riley Roth-Carter, Erin Helms, Joshua C. Saldivar, Jason Podrabsky

Biology Faculty Publications and Presentations

Hypoxia and anoxia suppress cell proliferation due to an increase in replication stress and activation of DNA damage checkpoints. Embryos of the annual killifish Austrofundulus limnaeus tolerate prolonged anoxia, indicating improved genomic stability under oxygen starvation. We investigated the cell cycle regulation of the anoxia tolerant killifish embryonic cell line PSU-AL-WS40NE during anoxia. Live-cell imaging confirms continued proliferation of WS40NE cells for the first 24 h of anoxia with minimal cell death. Fluorescence imaging shows that cells accumulate in G1 after the first day in anoxia with a rapid entry into S phase upon reoxygenation. Pharmacological inhibition shows a reliance …

Letter From The Editor

Notre Dame Journal of International & Comparative Law

No abstract provided.

Volume 16 Issue 3 - Full Issue

Notre Dame Journal of International & Comparative Law

No abstract provided.

From Mandela To Meta: Democratization Of The Right Of Publicity, Persona, And Image Rights In Cyberspace, Frederick W. Mostert, Lea Leisure

Notre Dame Journal of International & Comparative Law

No abstract provided.

Safe, Secure, And Affordable? The State Of Household Water Insecurity In California, Melissa Beresford, Wendy Jepson, Jeremiah Osborne-Gowey, Kristin Dobbin, Amanda Fencl, Silvia R. González, Gregory Pierce

Faculty Research, Scholarly, and Creative Activity

California's efforts to advance the Human Right to Water are constrained by limited household-level data on water insecurity. Using the 2021 CalSpeaks statewide probability survey (n = 628) this study offers the first representative look at water insecurity across California households. Results reveal significant water-related struggles: approximately 23% of respondents worried about having enough water to meet their household needs, 15% worried about perceived health impacts from water quality, and 7% struggled with affordability. Negative binomial regression models show that water insecurity is not randomly distributed: households with non-white residents, households which rely on private or small water companies for …

Correctional Officers' Perceptions Of Inmate Suicide In Florida State Prisons, Chrishelle Robbins

Walden Dissertations and Doctoral Studies

Correctional officers are responsible for the care, custody, safety, and supervision of inmates within jails, prisons, and correctional institutions. They face many hardships within a prison setting including inmate suicides. The purpose of this qualitative study was to explore and understand the perceptions of Florida state correctional officers who have experienced inmate suicide firsthand. This study was formulated using the transcendental, descriptive phenomenology approach and addressed the study’s research questions. Participants included nine Florida state certified correctional officers who witnessed an inmate suicide. Participants were selected using purposive snowball sampling. Interviews were scheduled and conducted via ZOOM or by telephone …

The Impact Of Super Political Action Committee Spending On Abortion Legislation In A Post-Dobbs Era, Jeni Atchley

Walden Dissertations and Doctoral Studies

Super political action committee (Super PAC) spending has become a prominent feature of U.S. elections, yet limited research had examined how independent expenditures related to electoral success in competitive U.S. House races and whether that relationship varied by candidates’ abortion policy positions in the post-Dobbs era. Prior research has shown that Super PAC independent expenditures expanded sharply after Citizens United and can influence candidate visibility in competitive races, yet findings on whether that spending translates into electoral success have been mixed, and few studies had examined it in relation to candidates' abortion positions after Dobbs. The purpose of this correlational …

Subscribe, Follow, Save: Podcast Preservation In The Platform Era, Ben Pettis, Jeremy Morris

Rhetoric and Communication Studies Faculty Publications

Podcasting has produced a glut of cultural content. Collecting and saving these sounds for future study, however, remains challenging. This article asks: “How are recent developments in the platformization of podcasting threatening the ability of users and researchers to save, study, and sustain podcasts and the cultural insights they offer?” To answer, we focus on a podcast preservation project, PodcastRE.org, and discuss strategies for creating an (un)stable repository for future studies of podcasting. While new developments challenge preservation efforts, they also offer archivists opportunities to prioritize the cultural significance of podcasts, rather than the economic motives of the podcast industry …

Deciphering The Association Of Fasting Blood Glucose With Gamma-Glutamyl Transferase And Uric Acid: A Cross-Sectional Study In A Tertiary Care Hospital In South India, Anbalagan Anithasri, Rajagambeeram Reeta, Velmurugan Hasini

Sultan Qaboos University Medical Journal

Objectives: Fasting hyperglycaemia (FHG) in insulin resistance is due to oxidative stress wherein gamma-glutamyl transferase (GGT) and uric acid (UA) are known to impair insulin secretion from pancreatic beta cells due to their pro-oxidant action and their role in metabolism of antioxidant glutathione. This study aims to determine the association of GGT and UA with FHG and its role in predicting the onset of prediabetes. Methods: This cross-sectional study was conducted in Government Villupuram Medical College, Villupuram, India, from July to December 2023. Individuals in the age range of 25–65 years attending the master health check-up clinic were included. …

The Hidden Net Cost Of Data Center Construction And Operation For Household Service Pricing, Arezou Shafaghat, Mikhail Klimenko, Da Hu, Ali Keyvanfar

Faculty Articles

The rapid expansion of artificial intelligence (AI) is accelerating data center construction and creating downstream implications for households. This study examines how AI-era data center costs (comprising construction, energy, water, grid upgrades, cooling, and lifecycle management) move through service supply chains and affect household prices in healthcare, transportation, education, banking, and commerce. It also considers the productivity and welfare benefits that AI may transmit. This study identifies four pass-through channels: utility-rate socialization of energy costs, cloud-platform pricing, sectoral pass-through from AI-adopting industries, and indirect effects through supply chains and labor markets. It introduces the AI-inflated net good basket, defined as …

The Use Of Breathing Meditation With Bipoc Trauma Survivors, Keerthi Sundaramurthy

Doctoral Dissertations

There is a growing body of evidence supporting the use of mindfulness-based practices to reduce psychological distress. Although interest in mindfulness-based care is growing, studies investigating virtual interventions for BIPOC trauma survivors remain limited. The goal of this study was to evaluate the effects of a breathing meditation intervention on mental health outcomes in a sample of trauma-exposed BIPOC adults, using a randomized post-test only design. Participants in the intervention group were asked to complete a 10-minute box breathing meditation daily for four weeks. Quantitative analyses revealed that those in the intervention group reported significantly lower symptoms of anxiety and …

The Tagmatized Echinoderm, Richard L. Turner

Ocean Engineering and Marine Sciences Faculty Publications

Synopsis Tagmosis is a derived condition of metamerism in annelids, arthropods, and chordates in which groups of adjacent segments are modified to perform specific functions. Examples are the clitellum of earthworms, the carapace of lobsters, and the sacrum of tetrapods, to mention a few. The argument is advanced here that examples of tagmosis are not hard to find among echinoderms, a fourth major group of metameric animals; but the degree of tagmosis is weak in most cases. The first few segments of the axial skeleton are often conjoined as a perioral tagma (e.g., the jaws and other parts of the …

The Effect Of Doping In Ferroelectric Hafnium Oxide, Adedamola David Aladese

Electronic Theses and Dissertations Archive

Ferroelectric hafnium oxide (HfO2) has emerged as a promising material for next-generation non-volatile memory and computing technologies because of its compatibility with complementary metal-oxide-semiconductor (CMOS) processing, scalability, and robust ferroelectricity. However, the atomistic mechanisms governing ferroelectric phase stabilization, defect interactions, and polarization switching remain incompletely understood, limiting the rational design of high-performance HfO2-based devices. This dissertation employs first-principles density functional theory calculations to establish atomistic design principles for engineering ferroelectricity in HfO2 through strain, dopant incorporation, oxygen-vacancy engineering, and multivalent defect chemistry. The effects of strain orientation, yttrium (Y) doping, and oxygen vacancies on ferroelectric phase stability were first investigated. …