Digital Commons Network^™

Heterogeneity Of Treatment Effect: The Case For Individualising Oxygen Therapy In Critically Ill Patients, Daniel S Martin, Michael P W Grocott

Peninsula Medical School

Oxygen therapy is ubiquitous in critical illness but oxygenation targets to guide therapy remain controversial despite several large randomised controlled trials (RCTs). Findings from RCTs evaluating different approaches to oxygen therapy in critical illness present a confused picture for several reasons. Differences in both oxygen target measures (e.g. oxygen saturation or partial pressure) and the numerical thresholds used to define lower and higher targets complicate comparisons between trials. The duration of and adherence to oxygenation targets is also variable with consequent substantial variation in both the dose and the dose separation. Finally, heterogeneity of treatment effects (HTE) may also be …

January 28, 2025 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Spartan Daily, January 28, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 2

A Note On The Weather, Arnold Berleant

Contemporary Aesthetics (Journal Archive)

No abstract provided.

Anatomical Variation Of The Aortic Arch Branches: A Case Report And Literature Review, Omer Abdelaziz, Ibrahim Abdalla, Mohammed Abdelmotalab

Iraqi National Journal of Medicine

Anatomical variations of the aortic arch branches have been documented; however, the occurrence of five branches arising directly from the aortic arch is rare. During the dissection of a 35-year-old male cadaver‘s thorax and neck region for undergraduate students in the academic year 2022–2023 at the Department of Anatomy, Faculty of Medicine, Delta College of Science and Technology, Omdurman City, Sudan, the aortic arch exhibited five direct branches: the left subclavian, left common carotid, left vertebral, right common carotid, and right subclavian arteries. Understanding such variations and their anatomical courses prior to surgical procedures holds significant clinical value.

An Innovative Method Of Singular Spectrum Analysis To Conduct Gap-Filling And Denoising On Time Series Data

Faculty, Staff and Student Publications

Heart rate data collected from wearable devices - one type of time series data - could provide insights into activities, stress levels, and health. Yet, consecutive missing segments (i.e., gaps) that commonly occur due to improper device placement or device malfunction could distort the temporal patterns inherent in the data and undermine the validity of downstream analyses. This study proposes an innovative iterative procedure to fill gaps in time series data that capitalizes on the denoising capability of Singular Spectrum Analysis (SSA) and eliminates SSA's requirement of pre-specifying the window length and number of groups. The results of simulations demonstrate …

Screening Young Adult Cancer Patients For Vocational Rehabilitation Services: A Vocational Rehabilitation Readiness Screening Tool, Melissa Scardaville, Sha-Ron Conley, David Farris, Michael Roth, Vinh Nguyen, Lex Frieden

Faculty, Staff and Student Publications

Purpose: We aimed to develop an online vocational rehabilitation (VR) readiness screening (VRRS) tool for young adults diagnosed with cancer. VR readiness was defined as being physically and cognitively ready to enter or return to work or school.

Methods: We developed an initial VRRS tool informed by previous studies, a scoping review to determine such a tool had not already been developed, and consultation with subject matter experts. We iteratively refined the tool on the basis of four rounds of interviews with young adults with cancer. The refined VRRS was then administered online to patients before they attended scheduled clinic …

Quantum Phase Transition Of Non-Hermitian Systems Using Variational Quantum Techniques, James Hancock, Matthew J. Craven, Craig Mcneile, Davide Vadacchino

School of Engineering, Computing and Mathematics

The motivation for studying non-Hermitian systems and the role of $\mathcal{PT}$-symmetry is discussed. We investigate the use of a quantum algorithm to find the eigenvalues and eigenvectors of non-Hermitian Hamiltonians, with applications to quantum phase transitions. We use a recently proposed variational algorithm. The systems studied are the transverse Ising model with both a purely real and a purely complex transverse field.

Safety And Efficacy Of Iv Onasemnogene Abeparvovec For Pediatric Patients With Spinal Muscular Atrophy: The Phase 3b Smart Study, Hugh J. Mcmillan, Craig M. Zaidman, Et Al.

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: Safety and efficacy of IV onasemnogene abeparvovec has been demonstrated for patients with spinal muscular atrophy (SMA) weighing < 8.5 kg. SMART was the first clinical trial to evaluate onasemnogene abeparvovec for participants weighing 8.5-21 kg.

METHODS: SMART was an open-label, multicenter, phase 3b study conducted across 13 sites in 9 countries (NCT04851873). Symptomatic pediatric participants with SMA (any type; treatment-naïve or had discontinued prior treatment) were stratified into 3 weight cohorts (≥8.5-13, >13-17, and >17-21 kg), administered onasemnogene abeparvovec, and followed for 52 weeks. Corticosteroids were initiated 24 hours before infusion with dose increases in response to adverse events (AEs) and subsequent tapering at investigator discretion. The primary objective was safety. Secondary objective was …

Explaining The 2022 Record Low Great Salt Lake Volume, Siiri Bigalke, Paul C. Loikith, Nicholas Siler

Geography Faculty Publications and Presentations

The Great Salt Lake reached the lowest water volume in its entire 170+ year record in 2022. To explain this record low we develop and apply a lake mass‐balance model and perform four simulations: one where all input and output variables are fixed to their mid‐20th century average resulting in an equilibrium lake volume, and three others where one of the input variables (precipitation or streamflow) or the output variable (evaporation) follows observations while the other two are fixed to their mid‐20th century average. Results show anomalously low streamflow accounting for the largest proportion of the lake volume departure from …

Performance And Safety Of The Extravascular Implantable Cardioverter Defibrillator Through Long-Term Follow-Up: Final Results From The Pivotal Study., Paul Friedman, Francis Murgatroyd, Lucas V A Boersma, Jaimie Manlucu, Bradley P Knight, Nicolas Clémenty, Christophe Leclercq, Anish Amin, Béla Merkely, Ulrika Maria Birgersdotter-Green, Joseph Yat Sun Chan, Mauro Biffi, Reinoud Elwin Knops, Gregory Engel, Ignacio Muñoz Carvajal, Laurence M Epstein, Venkata Sagi, Jens Brock Johansen, Maciej Sterliński, Clemens Steinwender, Troy Hounshell, Richard Abben, Amy E Thompson, Yan Zhang, Christopher Wiggenhorn, Sarah Willey, Ian Crozier

Heart and Vascular Articles

BACKGROUND: Substernal lead placement of the extravascular implantable cardioverter defibrillator (EV ICD) permits both defibrillation at thresholds similar to those seen with transvenous implantable cardioverter defibrillators and effective anti-tachycardia pacing (ATP) while avoiding the vasculature and associated complications. The global Pivotal study has shown the EV ICD system to be safe and effective through 6 months, but long-term experience has yet to be published. Our aim was to report the performance and safety of the EV ICD system throughout the study.

METHODS: The EV ICD Pivotal study was a prospective, global, single-arm, premarket clinical study. Individuals with a Class I …

A Cnt Intercalated Co Porphyrin-Based Metal Organic Framework Catalyst For Oxygen Reduction Reaction, Pei-Pei He, Jin-Hua Shi, Xiao-Yu Li, Ming-Jie Liu, Zhou Fang, Jing He, Zhong-Jian Li, Xin-Sheng Peng, Qing-Gang He

Journal of Electrochemistry

The poor electronic conductivity of metal-organic framework (MOF) materials hinders their direct application in the field of electrocatalysis in fuel cells. Herein, we proposed a strategy of embedding carbon nanotubes (CNTs) during the growth process of MOF crystals, synthesizing a metalloporphyrin-based MOF catalyst TCPPCo-MOF-CNT with a unique CNT-intercalated MOF structure. Physical characterization revealed that the CNTs enhance the overall conductivity while retaining the original characteristics of the MOF and metalloporphyrin. Simultaneously, the insertion of CNTs generated adequate mesopores and created a hierarchical porous structure that enhances mass transfer efficiency. X-ray photoelectron spectroscopic analysis confirmed that the C atom in CNT …

New Insights Into Controlling The Functional Properties Of Tin Oxide-Based Materials, Alexandra Kuriganova, Nina Smirnova

Journal of Electrochemistry

Development of methodologies for fabrications of nanostructured materials that provide control over their microstructural features and compositions represents a fundamental step in the advancement of technologies for productions of materials with well-defined functional properties. Pulse electrolysis, a top-down electrochemical approach, has been demonstrated to be a viable method for producing nanostructured materials with a particular efficacy in the synthesis of tin oxides. This method allows for significant control over the composition and shape of the resulting tin oxides particles by modifying the anionic composition of the aqueous electrolyte, obviating the need for additional capping agents in the synthesis process and …

Journal Of Electrochemistry Is Included In The World Journal Clout Index (Wjci) Report (2024), Editorial Office Of J.Electrochem.

Journal of Electrochemistry

No abstract provided.

Ramanujan–Fine Integrals For Level 10, Shaun Cooper, Timothy Huber, Jeffery Opoku

School of Mathematical & Statistical Sciences Faculty Publications

We investigate the question of when an eta quotient is a derivative of a formal power series with integer coefficients and present an analysis in the case of level 10. As a consequence, we establish and classify an infinite number of integral evaluations such as

∫e−2π/10√0q∏j=1∞(1−qj)3(1−q10j)8(1−q5j)7dq=14(10−45–√−−−−−−−−√−1). We describe how the results were found and give reasons for why it is reasonable to conjecture that the list is complete for level 10.

Humination Modification: A Green Approach To Improve The Material Properties Of Scots Pine (Pinus Sylvestris L.) Sapwood, Amir Ghavidel, Arantxa Eceiza, Xinfeng Xie, Reza Hosseinpourpia

Michigan Tech Publications

Recently, wood modification with environmentally friendly modification agents has received special attention. To this end, this study was conducted to use humin fractions, in combination with citric acid (CA) and succinic acid (SA), as reaction catalysts for the modification of Scots pine (Pinus sylvestris L.) sapwood. The effects of humination modification were evaluated by means of dimensional stability, static and dynamic mechanical properties, thermal stability, crystalline structure, and biological durability tests on modified samples and compared with the unmodified reference ones. According to the results, the dimensional stability of the huminated samples significantly increased, and this increase with the presence …

Charting Your Course: A Roadmap To Select A Review Type For Your Research Journey, Jannette Bradley, Barbara E. Ruggeri, Karen L. Hanus

Journal of Patient-Centered Research and Reviews

Summarizing evidence found in the literature is an important component of the research process. Researchers who undertake a project to summarize evidence will hopefully have their results published in a peer-reviewed journal. However, there are dozens of review types. Choosing the right review type is not always straightforward. The researcher’s process is much like a journey that requires careful charting to avoid wrong turns and wasted resources and potentially ensure that somebody else can replicate the process. Depending on the goal/destination, the researcher/traveler needs to choose the proper review type, or chart the right course, to select their route and …

Beyond The Status Of Health: A Collection Of Stories Representing Diverse Maternal Mental Health Perspectives, Sara Santarossa, Ruth A. Blake, Heather Buchanan, Mercedes Price, Rachael Guzzardo, Craig Guzzardo, Lakenya M. Johnson, Jacobeth M. Morshall, Andrea Bate, Wayne Bate, Riziki Bakari, Leah Copeland, Dana Murphy, Ashley Redding, Amy Loree

Journal of Patient-Centered Research and Reviews

As part of a Patient-Centered Outcomes Research Institute (PCORI) Eugene Washington Engagement Award aimed at improving capacity to address maternal mental health in research, this collection of eight stories describes the unique experiences from caregivers (N = 2), patient/caregiver dyads (N = 2), healthcare stakeholders (N = 2), and community stakeholders (N = 2). Shared here are narratives dedicated to uplifting and supporting maternal mental health through storytelling. Elevating the voices and lived experiences of these diverse perspectives helps one understand the deeper and sometimes “invisible” needs of birthing people, thus moving beyond the status quo.

Junior High Educators' Lived Experiences Of Self-Directed Learning For Teaching Online In 2020, April Vay Madsen

Walden Dissertations and Doctoral Studies

Researchers have identified common educator challenges in switching from face-to-face to online teaching, including time management, course content, communication, and the use of technology effectively. There is little or no research on the lived experiences of junior high school educators who applied self-directed learning skills to adapt to the changes in educational formats from March 2020 to September 2020. This qualitative study aimed to explore these experiences as educators transitioned to online teaching due to the COVID-19 pandemic. Mezirow’s transformational learning theory and Knowles et al.’s adult learning assumptions are used as the theoretical and conceptual frameworks, respectively. Giorgi’s descriptive …

Effective Marketing And Monetization Strategies Used In Small Independent Game Development, Jessica Nicole Mobley

Walden Dissertations and Doctoral Studies

A lack of effective marketing and monetization strategies negatively affects the ability of small independent game developers to complete projects within budget and on time, resulting in revenue losses. Grounded in platform theory, the purpose of this qualitative pragmatic inquiry study was to identify and explore effective marketing and monetization strategies used by small independent game developers to complete projects within budget and on time. The participants were a global, online group of four small independent game developers, each of whom successfully used marketing and monetization strategies to manage budgets and timelines. Data were collected from semistructured interviews and publicly …

The Mediating Role Of Trust On Tacit Knowledge Sharing And Job Satisfaction, Shami Orinthea Miller

Walden Dissertations and Doctoral Studies

Effective knowledge management is vital for organizational success. However, challenges in knowledge gaps arise when key individuals depart from their respective organizations and there is no effective knowledge management system. This study was an exploration of the nuanced relationship among trust, tacit knowledge sharing, and job satisfaction in the life insurance industry. Trust, job satisfaction, and tacit knowledge sharing are critical components in organizational dynamics. Tacit knowledge sharing is difficult to codify, and employees might be motivated to share their know-how on the basis of anticipated benefits and reciprocal interactions. On the other hand, research that explores the relationship between …

Improving Self-Care Deficit In Schizophrenia Patients, Ihuoma Onwanma Chuks

Walden Dissertations and Doctoral Studies

Schizophrenia adversely affects the brain, leading to impaired perception, emotion, and behavior, making it one of the leading conditions that results in self-care deficit. The self-care deficit problem will emerge due to the inability of a patient with schizophrenia to take care of themselves due to behavioral, perceptual, or cognitive issues. The purpose of this project was to implement a staff education program for nurses working in a Mid-Atlantic behavioral and mental health hospital on how to assist patients who have schizophrenia manage their self-care. The questions that guided this project focused on if there was an improvement in nurses’ …

Staff Education Project Depression Screening Education, Olayemi Ikhile

Walden Dissertations and Doctoral Studies

The primary care setting is one of the most common settings where patients with depression present. Despite this, many primary care clinicians may not feel adequately equipped to diagnose and treat depression effectively. Increasing depression screening is one of the ways to improve the early detection and treatment of depression in primary care settings. This paper describes a staff education project on depression screening among nurses at a primary care health clinic in the South-Central area of the United States. The purpose of the project was to develop, implement, and evaluate a staff education program on depression screening. The goal …

Executive Summary: Staff Education Project Staff Education To Improve Knowledge Regarding The Education Patient Intake Assessment, Dalila Kim

Walden Dissertations and Doctoral Studies

Evaluation of diabetes management processes at a western primary care clinic found that medical assistants lacked knowledge regarding the use of diabetes assessment tools. This Doctor of Nursing Practice (DNP) staff education project focused on enhancing medical assistants’ knowledge of the Education Patient Intake Template Assessment Tool to support best practices in T2DM care. A review of current literature using the Johns Hopkins Hierarchy of Evidence Guide identified that evidence from Level I to III informed the project. Six medical assistants, the primary patient screeners in the primary care clinic, participated in the intervention. I used pre- and postintervention tests …

Junior High Educators' Lived Experiences Of Self-Directed Learning For Teaching Online In 2020, April Vay Madsen

Walden Dissertations and Doctoral Studies

Researchers have identified common educator challenges in switching from face-to-face to online teaching, including time management, course content, communication, and the use of technology effectively. There is little or no research on the lived experiences of junior high school educators who applied self-directed learning skills to adapt to the changes in educational formats from March 2020 to September 2020. This qualitative study aimed to explore these experiences as educators transitioned to online teaching due to the COVID-19 pandemic. Mezirow’s transformational learning theory and Knowles et al.’s adult learning assumptions are used as the theoretical and conceptual frameworks, respectively. Giorgi’s descriptive …

Effective Marketing And Monetization Strategies Used In Small Independent Game Development, Jessica Nicole Mobley

Walden Dissertations and Doctoral Studies

A lack of effective marketing and monetization strategies negatively affects the ability of small independent game developers to complete projects within budget and on time, resulting in revenue losses. Grounded in platform theory, the purpose of this qualitative pragmatic inquiry study was to identify and explore effective marketing and monetization strategies used by small independent game developers to complete projects within budget and on time. The participants were a global, online group of four small independent game developers, each of whom successfully used marketing and monetization strategies to manage budgets and timelines. Data were collected from semistructured interviews and publicly …

The Mediating Role Of Trust On Tacit Knowledge Sharing And Job Satisfaction, Shami Orinthea Miller

Walden Dissertations and Doctoral Studies

Effective knowledge management is vital for organizational success. However, challenges in knowledge gaps arise when key individuals depart from their respective organizations and there is no effective knowledge management system. This study was an exploration of the nuanced relationship among trust, tacit knowledge sharing, and job satisfaction in the life insurance industry. Trust, job satisfaction, and tacit knowledge sharing are critical components in organizational dynamics. Tacit knowledge sharing is difficult to codify, and employees might be motivated to share their know-how on the basis of anticipated benefits and reciprocal interactions. On the other hand, research that explores the relationship between …

Improving Self-Care Deficit In Schizophrenia Patients, Ihuoma Onwanma Chuks

Walden Dissertations and Doctoral Studies

Schizophrenia adversely affects the brain, leading to impaired perception, emotion, and behavior, making it one of the leading conditions that results in self-care deficit. The self-care deficit problem will emerge due to the inability of a patient with schizophrenia to take care of themselves due to behavioral, perceptual, or cognitive issues. The purpose of this project was to implement a staff education program for nurses working in a Mid-Atlantic behavioral and mental health hospital on how to assist patients who have schizophrenia manage their self-care. The questions that guided this project focused on if there was an improvement in nurses’ …

Staff Education Project Depression Screening Education, Olayemi Ikhile

Walden Dissertations and Doctoral Studies

The primary care setting is one of the most common settings where patients with depression present. Despite this, many primary care clinicians may not feel adequately equipped to diagnose and treat depression effectively. Increasing depression screening is one of the ways to improve the early detection and treatment of depression in primary care settings. This paper describes a staff education project on depression screening among nurses at a primary care health clinic in the South-Central area of the United States. The purpose of the project was to develop, implement, and evaluate a staff education program on depression screening. The goal …

College Faculty Perceptions Of The Challenges Of Online And Virtual Instruction, Joyceline Resha Poole-Dudley

Walden Dissertations and Doctoral Studies

The problem addressed through this study is that faculty at a local college in the southern United States experienced challenges adjusting teaching modality from face-to-face to online following the pandemic. The purpose of this basic qualitative study was to explore the perceptions of college faculty about the challenges they have experienced and recommendations for adjusting teaching modality from face-to-face to online at a local southern college. The conceptual framework was Dawis and Lofquist’s theory of work adjustment. Using a basic qualitative design, data were collected through semistructured interviews with nine faculty who were selected using purposeful sampling. Open and axial …