Digital Commons Network^™

Geographic Disparities Impacting Oral Vaccine Performance: Observations And Future Directions, Rachel M Burke, Sasirekha Ramani, Julia Lynch, Laura V Cooper, Haeun Cho, Ananda S Bandyopadhyay, Carl D Kirkwood, A Duncan Steele, Gagandeep Kang

Faculty, Staff and Students Publications

Oral vaccines have several advantages compared with parenteral administration: they can be relatively cheap to produce in high quantities, easier to administer, and induce intestinal mucosal immunity that can protect against infection. These characteristics have led to successful use of oral vaccines against rotavirus, polio, and cholera. Unfortunately, oral vaccines for all three diseases have demonstrated lower performance in the highest-burden settings where they are most needed. Rotavirus vaccines are estimated to have >85% effectiveness against hospitalization in children < 12 months in countries with low child mortality, but only ~65% effectiveness in countries with high child mortality. Similarly, oral polio vaccines have lower immunogenicity in developing country settings compared with high-resource settings. Data are more limited for oral cholera vaccines, but suggest lower titers among children compared with adults, and, for some vaccines, lower efficacy in endemic settings compared with non-endemic settings. These disparities are likely multifactorial, and available evidence suggests a role for maternal factors (e.g. transplacental antibodies, breastmilk), host factors (e.g. genetic polymorphisms-with the best evidence for rotavirus-or previous infection), and environmental factors (e.g. gut microbiome, co-infections). Overall, these data highlight the rather ambiguous and often contradictory nature of evidence on factors affecting oral vaccine response, cautioning against broad extrapolation of outcomes based on one population or one vaccine type. Meaningful impact on performance of oral vaccines will likely only be possible with a suite of interventions, given the complex and multifactorial nature of the problem, and the degree to which contributing factors are intertwined.

Comparative Outcomes Of Endovascular Vs. Surgical Treatment In Craniocervical Junction Dural Arteriovenous Fistulas: A Systematic Review And Meta-Analysis, Basel Musmar, Joanna Roy, Atakan Orscelik, Sravanthi Koduri, Spyridon Karadimas, Saman Sizdahkhani, Elias Atallah, Stavropoula Tjoumakaris, Michael Gooch, Hekmat Zarzour, Ritam Ghosh, Richard Schmidt, Robert Rosenwasser, Pascal Jabbour

Department of Neurosurgery Faculty Papers

BACKGROUND: Craniocervical junction dural arteriovenous fistulas (CCJ-DAVFs) are rare and complex vascular malformations that are challenging to diagnose and treat. This study aims to compare surgical and endovascular treatments for CCJ-DAVFs through a systematic review and meta-analysis.

METHODS: A systematic review and meta-analysis was conducted according to the PRISMA guidelines. PubMed, Scopus, and Web of Science databases were searched from inception to July 2024.

RESULTS: Fifteen studies involving 266 patients were included. Of these, 143 (53.8 %) patients underwent surgical treatment alone and 123 (46.2 %) underwent endovascular treatment alone. In the surgical group, the complete obliteration rate at last …

Co2 Electrolysis Using Metal-Supported Solid Oxide Cells With Infiltrated Pr0.5Sr0.4Mn0.2Fe0.8O3−Δ Catalyst, Boxun Hu, Ka-Young Park, Asia Sarycheva, Robert Kostecki, Fanglin Chen, Michael C. Tucker

Faculty Publications

Electrochemical conversion of CO₂ to CO is demonstrated with symmetric-structured metal supported solid oxide cells (MS-SOC). Perovskite Pr_0.5Sr_0.4Mn_0.2Fe0.8O_3−δ (PSMF) and Pr₆O₁₁ catalysts were infiltrated into the MS-SOC cathode and anode, using 3 cycles with firing at 850 °C and 8 cycles with firing at 800 °C, respectively. Upon reduction during operation, the perovskite PSMF was transformed to Ruddlesden–Popper structure with a highly efficient electrocatalytic activity. The impact of operating temperature (600–800 °C) and overpotential (0–1.8 V) on the CO₂ conversion was investigated. The highest CO₂ conversion …

Traf2 And Ripk1 Redundantly Mediate Classical Nfκb Signaling By Tnfr1 And Cd95-Type Death Receptors, Jennifer Wagner, David Vredevoogd, Xin Yu, Dong Lu, Daniel S Peeper, Heike M Hermanns, Jin Wang, Harald Wajant, Daniela Siegmund

Faculty, Staff and Students Publications

This study suggests a modified model of TNFR1-induced complex I-mediated NFκB signaling. Evaluation of a panel of five tumor cell lines (HCT116-PIK3CAmut, SK-MEL-23, HeLa-RIPK3, HT29, D10) with TRAF2 knockout revealed in two cell lines (HT29, HeLa-RIPK3) a sensitizing effect for death receptor-induced necroptosis and in one cell line (D10) a mild sensitization for TNFR1-induced apoptosis. TRAF2 deficiency inhibited death receptor-induced classical NFκB-mediated production of IL-8 only in a subset of cell lines and only partly. TRAF5, furthermore, failed to improve DR-induced NFκB signaling in HCT116-PIK3CAmut and HCT116-PIK3CAmut-TRAF2KO cells. These findings argue for a non-obligatory role of TRAF2 in death receptor-induced …

The Link January 21, 2025, Access To Justice Institute

The Link Newsletter

No abstract provided.

Gut Microbial Changes Associated With Obesity In Youth With Type 1 Diabetes, Heba M Ismail, Dimuthu Perera, Rabindra Mandal, Linda A Dimeglio, Carmella Evans-Molina, Tamara Hannon, Joseph Petrosino, Sara Javornik Cregeen, Nathan W Schmidt

Faculty, Staff and Students Publications

Context: Obesity is prevalent in type 1 diabetes (T1D) and is problematic with higher risk for diabetes complications. It is unknown to what extent gut microbiome changes are associated with obesity and T1D.

Objective: This work aimed to describe the gut microbiome and microbial metabolite changes associated with obesity in T1D. We hypothesized statistically significant gut microbial and metabolite differences in lean T1D youth (body mass index [BMI]: 5%-< 85%) vs those with obesity (BMI: ≥95%).

Methods: We analyzed stool samples for gut microbial (using metagenomic shotgun sequencing) and short-chain fatty acid (SCFA) differences in lean (n = 27) and obese (n = 21) T1D youth in …

Real-Time Cbct Imaging And Motion Tracking Via A Single Arbitrarily-Angled X-Ray Projection By A Joint Dynamic Reconstruction And Motion Estimation (Dreme) Framework, Hua-Chieh Shao, Tielige Mengke, Tinsu Pan, You Zhang

Faculty, Staff and Student Publications

Objective: Real-time cone-beam computed tomography (CBCT) provides instantaneous visualization of patient anatomy for image guidance, motion tracking, and online treatment adaptation in radiotherapy. While many real-time imaging and motion tracking methods leveraged patient-specific prior information to alleviate under-sampling challenges and meet the temporal constraint (< 500 ms), the prior information can be outdated and introduce biases, thus compromising the imaging and motion tracking accuracy. To address this challenge, we developed a framework dynamic reconstruction and motion estimation (DREME) for real-time CBCT imaging and motion estimation, without relying on patient-specific prior knowledge.

Approach: DREME incorporates a deep learning-based real-time CBCT imaging and motion estimation method into a dynamic CBCT reconstruction framework. The reconstruction framework reconstructs a dynamic sequence of CBCTs in a data-driven manner from a standard pre-treatment scan, without requiring patient-specific prior knowledge. Meanwhile, a convolutional neural network-based motion encoder is jointly trained during the reconstruction …

Of Duty And Distress: Addressing Sea Slavery Through The Duty To Render Assistance, Austin Fullmer

International Law Studies

Sea slavery—men trapped in forced labor on board illegal, unreported, and unregulated (IUU) fishing vessels—exists across the world’s oceans. If confronted with sea slavery while conducting a boarding of a foreign-flagged IUU fishing vessel on the high seas, may a coastal State military officer free the victim? This article answers the question affirmatively, relying on the duty to render assistance under the international law of the sea. That duty requires all mariners who receive information that a person is in distress to proceed with all speed to assist the person in distress. In order to meet the definition of “distress,” …

Assessing The Interrelationships Of Sustainability Drivers In The Liner Shipping Industry: A South Korean Perspective, Junseung Kim, Stavros Karamperidis, Lijun Tang, Saeyeon Roh

Plymouth Business School

Container shipping companies play a crucial role in global trade and bear significant social and environmental responsibilities. Given resource constraints, identifying key sustainable drivers is essential for guiding investments. This study explores sustainability drivers in South Korean liner shipping companies using stakeholder theory. Through literature reviews, expert interviews, and fuzzy Decision-Making Trial and Evaluation Laboratory (f-DEMATEL) method, six key drivers were identified. Sustainability performance improvement emerged as the most important driver. The study also reveals complex casual relationships among the drivers. These findings offer valuable academic and managerial insights.

Ijrtp Volume 12(Iv) Table Of Contents, Ian S. Mcintosh, Dane Munro, Dagnachew Leta Senbeto, Kevin A. Griffin, Carlos Fernandes, Razaq Raj

International Journal of Religious Tourism and Pilgrimage

Special Issue: Papers Presented at Sacred Journeys 11th Global Conference - Pilgrimage: A Growing Global Phenomenon, Waijun Kaikan Conference Center, Chion-In Buddhist Temple, Kyoto, Japan, July 1-4, 2024

Pilgrimage: A Growing Global Phenomenon - Editorial, Dane Munro, Dagnachew Leta Senbeto, Ian S. Mcintosh

International Journal of Religious Tourism and Pilgrimage

Editorial and introduction to Special Issue of papers presented at Sacred Journeys 11th Global Conference - Pilgrimage: A Growing Global Phenomenon, Waijun Kaikan Conference Center, Chion-In Buddhist Temple, Kyoto, Japan, July 1-4, 2024

Rebuilding Possible: Pilgrimage And Learned Helplessness, Christianna Soumakis

International Journal of Religious Tourism and Pilgrimage

Learned helplessness is a belief in one’s own powerlessness which may develop after repeated exposure to stressful situations ranging from domestic abuse to public education. It is associated with pessimism, passivity in the face of obstacles, and depression. Pilgrimage, conversely, is associated with agency — striking out on one’s own in search of physical, emotional, cognitive, and / or spiritual transformation. Combining psychological literature with my personal experience as a pilgrim, special education student, artist, art facilitator for people with special needs, and professor, I argue that walking pilgrimages such as the Camino de Santiago offer a comprehensive opportunity to …

Navigating Liminal Moments Through Pilgrimage: Insights From The Journey Of St. Clare Of Assisi, Alexandria M. Egler, John V. Kruse

International Journal of Religious Tourism and Pilgrimage

During the late hours of Palm Sunday in 1209, Clare Offreduccio embarked on a pilgrimage that would come to define her as a leader and role model for women. In an act of faith and bravery, St. Clare of Assisi abandoned her life as a noble and all of the security, power, and privilege that came with it. In so doing, she denied the marriage plans her family had for her that would advance their political, social, and economic future. By exiting her home through the door of death and then the city of Assisi through one of the fortified …

Women Walking: Experiences Of Sacred Time On Mexican Guadalupan Pilgrimage, Sadie Yates

International Journal of Religious Tourism and Pilgrimage

Each July, 60,000 Catholic pilgrims walk from their home state of Querétaro, Mexico, to the Basilica of the Virgin of Guadalupe in Mexico City, a journey totaling 17 days and 450 km. Roughly 25,000 of these pilgrims are women, who walk in their own group, one day ahead of the men (Catholic News Agency, 2018). The goal of this pilgrimage is to see the Virgin of Guadalupe, a strong symbol of Catholic and Mexican identity since her original appearance to an indigenous peasant man in 1531. Yet, for many of these women pilgrims, the pilgrimage process is just as important …

A Sacred Mountain And Storytelling About Pilgrimage: Contemporary Religious Practice Of Incense Associations At Mount Tai, Ziqi Xuan

International Journal of Religious Tourism and Pilgrimage

As a form of pilgrimage in China, the Chaoshan jinxiang (朝山進香, ‘offering incense towards the mountain’), is a ritual that has garnered significant academic attention. However, research on contemporary incense offering practices remains inadequate. Grounded in fieldwork conducted from September 2023 to January 2024, this paper delves into the pilgrimage practices of local incense associations at Mount Tai, a historical site steeped in profound religious significance for centuries. Within the framework of collective memory studies, the paper posits that the contemporary practices of incense offering used to connect with spiritual beings during the pilgrimage to Mount Tai highlight a shift …

Khuralgarh Sahib: A Pilgrimage Destination For Adi Dharm Followers, Anna V. Bochkovskaya

International Journal of Religious Tourism and Pilgrimage

In the 1920s, a protest movement named Ad(i) Dhar(a)m, or Original Religion, emerged in the British province of Punjab with the aim of establishing a religious identity for the untouchable castes and low-caste people, basically from the Sikh community. The Adi Dharmis venerated Sant (Saint) Ravidas, a medieval mystic poet, a Chamar or tanner by origin. The list of their gurus also included Maharishi Valmiki, the legendary first poet — Adi Kavi, or the author of Ramayana, as well as two low-caste Bhakti poets — Kabir and Namdev.

The colonial Census of 1931 listed Adi Dharm as a new religion …

The Kyoto Trail: Sacred Sites On A Pseudo-Pilgrimage, Wayne E. Arnold, John A. Shultz

International Journal of Religious Tourism and Pilgrimage

How should we conceive of a secular walking trail that traverses a country’s premier holy sites in and around its spiritual capital? The Kyoto Trail is something of an oddity in comparison to the plentiful sacred walking paths throughout Japan. The 84-kilometer circuit probes and circumambulates the city of Kyoto via a horseshoe-like arc. It links an array of holy mountains with lush realms of nature and connects dozens of famous pilgrimage locations of exceptionally varied descriptions. However, while the trail sometimes overlaps with medieval pilgrimage routes, it is a relatively new course, established in the early 1990s through initiatives …

Ndls Communicator: Week Of 01.21.25, Notre Dame Law School

NDLS Communicator

The Latest News

• Special Education Law Clinic launched to support families of children with disabilities
• Rev. Patrick E. Reidy, C.S.C., and Nell Jessup Newton receive AALS Section Awards
• Jack Ferguson '24 J.D. awarded the 2024 Brown Award for Excellence in Legal Writing

Faculty News and Briefs

• Nicole Garnett and John Meiser were quoted in The Observer about their continued legal support for St. Isidore of Seville Catholic Virtual School in Oklahoma.
• The Lindsay and Matt Moroun Religious Liberty Clinic was also mentioned in Baptist Standard about the Perez v. City of San Antonio case.
• Jimmy Gurulé was quoted in an …

The Association Between Thyroid Differentiation Score And Survival Outcomes In Papillary Thyroid Carcinoma, Jennifer R Wang, Mark E Zafereo, Maria E Cabanillas, Chia Chin Wu, Li Xu, Yaoyi Dai, Wenyi Wang, Stephen Y Lai, Ying Henderson, Lauren Erasmus, Michelle D Williams, Corinne Joshu, Debashree Ray

Faculty, Staff and Student Publications

Context: Thyroid differentiation score (TDS), calculated based on mRNA expression levels of 16 genes controlling thyroid metabolism and function, has been proposed as a measure to quantify differentiation in papillary thyroid carcinoma (PTC).

Objective: The objective of this study is to determine whether TDS is associated with survival outcomes across patient cohorts.

Methods: Two independent cohorts of patients with PTC were used: (1) The Cancer Genome Atlas (TCGA) thyroid cancer study (N = 372), (2) MD Anderson Cancer Center (MDACC) cohort (N = 111). The primary survival outcome of interest was progression-free interval (PFI). Association with overall survival (OS) was …

Pediatric Papillary Thyroid Carcinoma: Outcomes After Surgery Without Adjuvant Radioactive Iodine, Luz E Castellanos, Mark E Zafereo, Erich M Sturgis, Jennifer R Wang, Anita K Ying, Steven G Waguespack

Faculty, Staff and Students Publications

Context: Pediatric papillary thyroid carcinoma (PTC) is usually treated with total thyroidectomy followed by radioactive iodine (RAI). Recently, RAI has been used more selectively based on surgical pathology and postoperative dynamic risk stratification (DRS).

Objective: To describe patients with pediatric PTC not initially treated with RAI and their disease outcomes.

Methods: This was an ambispective study at a tertiary cancer center of patients < 19 years diagnosed from January 1, 1990, to December 31, 2021, with stage 1 PTC who intentionally were not treated with RAI within a year of diagnosis. We assessed clinical characteristics, management, and disease outcomes using DRS.

Results: Of 490 PTC patients, we identified 93 eligible patients (median age at diagnosis 16 years; 87% female), including 46 (49%) with cervical lymph node metastases. Initial management included total thyroidectomy ± neck dissection (n = 69, …

Gut Microbial Changes Associated With Obesity In Youth With Type 1 Diabetes, Heba M Ismail, Dimuthu Perera, Rabindra Mandal, Linda A Dimeglio, Carmella Evans-Molina, Tamara Hannon, Joseph Petrosino, Sara Javornik Cregeen, Nathan W Schmidt

Center for Medical Ethics and Health Policy Staff Publications

Context: Obesity is prevalent in type 1 diabetes (T1D) and is problematic with higher risk for diabetes complications. It is unknown to what extent gut microbiome changes are associated with obesity and T1D.

Objective: This work aimed to describe the gut microbiome and microbial metabolite changes associated with obesity in T1D. We hypothesized statistically significant gut microbial and metabolite differences in lean T1D youth (body mass index [BMI]: 5%-< 85%) vs those with obesity (BMI: ≥95%).

Methods: We analyzed stool samples for gut microbial (using metagenomic shotgun sequencing) and short-chain fatty acid (SCFA) differences in lean (n = 27) and obese (n = 21) T1D youth in …

A Poetry Collection By Kev Minh Allen, Kev Minh Allen

Journal of Southeast Asian American Education and Advancement

This is a poetry collection by Kev Minh Allen.

A Poetry Collection By Soul Vang, Soul Vang

Journal of Southeast Asian American Education and Advancement

This is a poetry collection from Soul Vang.

Prison Sentences: Spaces Of Liberation In Arab Prison Writing, Joseph Farag

CLCWeb: Comparative Literature and Culture

Spatial and temporal motifs predominate throughout the extensive corpus of Arabic prison writing. However, far from establishing the prison as an exceptional space, and periods of imprisonment as “time outside time,” this paper argues that modern Arabic prison literature tends instead to blur the distinction between “inside” and “outside” prison space and time. In place of a rigid spatial demarcation, dramatically exemplified by images of towering, razor wire-tipped walls, Arabic prison writing consistently seeks to create continuity between the punishment meted out to those within the prison’s walls and the repression endured by those beyond it. Consequently, these texts figuratively …

Punish Yet Cannot Discipline: Two Iraqi Prison Novels, Hanan Jasim Khammas

CLCWeb: Comparative Literature and Culture

Al-Munāḍil (The Militant) (1972) by ʿAzīz al-Sayyid Jāsim, and Iʿjām (Iʿjaam) (2004) by Sinan Antoon are two prison novels about the historical turning points which mark the rise and fall of the Baʿth regime in Iraq. While the first employs imprisonment as a lens through to expose the corruption and injustice exercised by the monarchy against the emergent revolutionary power, the second shows the Baʿthist government applying similar methods of surveillance, and of physical and psychological torture. Reading these texts by al-Sayyid Jāsim, who died in the Baʿth prisons, and by Antoon who wrote Iʿjaam …

Hold Fast The Rope Of God: Space, Authority, And Speech In Muslim Prison Narratives, Basit Kareem Iqbal, Walaa Quisay

CLCWeb: Comparative Literature and Culture

Scholarship about Muslims in prison has been overwhelmingly dominated by security studies’ radicalization thesis and by a superficial reading of incarcerated Muslims’ “religious resilience.” Such approaches caricature the force of Islam in prison and indeed in Muslim prison narratives. This essay draws on interviews with survivors of prisons in Egypt, the United Arab Emirates, and Syria in order to develop other terms for analysis. Across our textual and ethnographic engagements, we read for varied permutations of carceral space, formations of religious authority, and an intimate (witnessing) relation between speech and violence. Muslim prison narratives see a broad emphasis on the …

The Networks Of Prison Narrative: Imagining Sociality And Making Narrative In Assad’S Syria, Anne-Marie Mcmanus

CLCWeb: Comparative Literature and Culture

This article argues for a new reading of collectivity – in both narrative voice and scenes of shared experience – in works of Syrian prison literature. Although these texts were published and are interpreted as the products of single author figures, the wider narrative field from which they emerge is shaped by numerous collective practices, from the oral and written to the digital. Breaking disciplinary boundaries around prison literature, this article introduces the term “prison narrative” and foregrounds diverse efforts by Syrian writers and former prisoners to imagine alternative formations of national experience and community under the Assad regime (1970-2024). …

Prison As A Living Being: ‘Assad’S Syria’ As A Model For The Imprisonment State, Jaber Baker

CLCWeb: Comparative Literature and Culture

The Syrian Assad regime used prisons as tools of domination. As such, prisons had the power not only of active repression but also as places of detention and disappearance for Syrians. The expansion of political detention in Syria over fifty years transformed prison into a living being in the sense that prison became a part not just of Syrians' political life, but also of their social identity. One can recognize it in voices, attitudes, lifestyles, and even written and oral culture. Syrian cities are full of weapons since a large area of the urban space is inhabited by the buildings …

From Prison To The World: A Comparative Reading Of Naji’S Hirz Mikamkim (Rotten Evidence, 2020) And Abd El-Fattah’S You Have Not Yet Been Defeated (2021), Teresa Pepe

CLCWeb: Comparative Literature and Culture

This article analyses Ahmed Naji’s Hirz Mikamkim (Rotten Evidence) and Alaa Abd el-Fattah’s You Have Not Yet Been Defeated through the lens of ‘prison literature’, that is “literary works produced in, about, or through the experience of political detention” (Taleghani 13). Comparing them to previous forms of prison literature from Egypt, it shows that both books depart from the social-realistic mode that has prevailed throughout the 20^th century. Rather they renovate the genre with aesthetic traits drawn from postmodern and digital literature, exemplified by autofictional or anonymous modes of authorship and co-authorship, narrative fragmentation, and bodily exposures. These aesthetic …

Khairy Shalaby’S Novel The City Of The Enslaved: Egyptian Prison Literature With A Russian Twist, Sarali Gintsburg

CLCWeb: Comparative Literature and Culture

Although the interconnectedness of Russian and Arabic literatures has been demonstrated by Soviet/Russian and, to a limited extent, Western Arabists, this research remains limited to a few names. However, the role that the Russian/Soviet literary tradition had in shaping contemporary genres of Arabic literature is complex and diverse. This is, for instance, the case with prison literature—Russian/Soviet literature has a long tradition of turning to the topic of imprisonment. It was Dostoyevsky, who turned to the genre of katorzhnaya proza (prison literature) and popularized it. Later, Tolstoy, Chekhov, and Gorky dedicated a number of their influential literary works to further …