Digital Commons Network^™

Comparative Single-Cell Analysis Reveals Tendon Progenitor Dysfunction By Age-Associated Oxidative Stress And Its Restoration By Antioxidant Treatments, Youngjae Jeong, Dongwook Yang, Jea Giezl Solidum, Laura Ortinau, Dongsu Park

Faculty, Staff and Students Publications

Impaired healing of adult tendons with fibrosis remains clinical challenges while neonatal tendons have full functional restoration. However, age-associated cellular and molecular changes in tendon cells and tendon stem/progenitor cells (TSPCs) remain unknown. Here, comparative single cell transcriptomics of early postnatal (2 weeks old) and adult (20 weeks old) mouse tendons revealed that adult tendons have reduced number of TSPCs, decreased gene expression in tendon and cartilage development, and a greater population of fibro-tenogenic cells. Notably, adult TSPCs and tenocytes exhibit increased expression of immune-response and oxidative-stress genes with higher EGFR but decreased IGF signaling. Adult tendon cells show increased …

Wonoep Appraisal: Targeted Therapy Development For Early Onset Epilepsies, Pablo M Casillas-Espinosa, Jennifer C Wong, Wanda Grabon, Ana Gonzalez-Ramos, Massimo Mantegazza, Nihan Carcak Yilmaz, Manisha Patel, Kevin Staley, Raman Sankar, Terence J O'Brien, Özlem Akman, Ganna Balagura, Adam L Numis, Jeffrey L Noebels, Stéphanie Baulac, Stéphane Auvin, David C Henshall, Aristea S Galanopoulou

Faculty, Staff and Students Publications

The early onset epilepsies encompass a heterogeneous group of disorders, some of which result in drug-resistant seizures, developmental delay, psychiatric comorbidities, and sudden death. Advancement in the widespread use of targeted gene panels as well as genome and exome sequencing has facilitated the identification of different causative genes in a subset of these patients. The ability to recognize the genetic basis of early onset epilepsies continues to improve, with de novo coding variants accounting for most of the genetic etiologies identified. Although current disease-specific and disease-modifying therapies remain limited, novel precision medicine approaches, such as small molecules, cell therapy, and …

Relationship Between Gestational Weight Gain With Fetal Body Composition And Organ Volumes In The Eunice Kennedy Shriver National Institute Of Child Health And Human Development (Nichd) Fetal Dimensional Study: A Prospective Pregnancy Cohort, Kathryn A Wagner, Zhen Chen, Stefanie N Hinkle, Jessica L Gleason, Wesley Lee, William A Grobman, John Owen, Roger B Newman, Daniel W Skupski, Dian He, Seth Sherman, Robert E Gore-Langton, Cuilin Zhang, Jagteshwar Grewal, Katherine L Grantz

Faculty, Staff and Students Publications

Background: Inadequate and excessive gestational weight gain (GWG) are associated with increased risk of newborn small- and large-for-gestational-age, respectively, and future offspring adiposity. However, the relationship between GWG and three-dimensional (3D) measures of fetal body composition and organ volumes, which may provide greater insight into fetal growth via measurement of soft tissue, remains unknown.

Objectives: The objective of this study was to examine the relationship between trimester-specific GWG and 3D fetal body composition and organ volume measurements.

Methods: In a diverse, US prospective pregnancy cohort, trimester-specific GWG was calculated as difference between maternal weight at beginning and end of each …

Tale Of Two Requesters: How Public Records Law Experiences Differ By Requester Types, A. Jay Wagner, David Cuillier

College of Communication Faculty Research and Publications

The journalism industry was central to the materialization of U.S. freedom of information (FOI) laws, yet journalists frequently voice dissatisfaction with the state of FOI laws. The study surveyed 330 public records requesters on their experiences with FOI laws, finding public-interest requesters (journalists, academics, nonprofits, and private individuals) reported a significantly different experience, including a lower likelihood of receiving records, than for-profit requesters (commercial requesters and lawyers). For-profit requesters were less likely to believe FOI laws positively impact government accountability or improve society. The findings suggest reassessing whom the laws serve and whether they meet their original democratic objectives.

Emapalumab Treatment In Patients With Rheumatologic Disease-Associated Hemophagocytic Lymphohistiocytosis In The United States: A Retrospective Medical Chart Review Study, Shanmuganathan Chandrakasan, Carl E Allen, Deepika Bhatla, John Carter, May Chien, Robert Cooper, Lauren Draper, Olive S Eckstein, Rabi Hanna, J Allyson Hays, Michelle L Hermiston, Ashley P Hinson, Patricia M Hobday, Michael S Isakoff, Michael B Jordan, Jennifer W Leiding, Renee Modica, Taizo A Nakano, Abiola Oladapo, Sachit A Patel, Priti Pednekar, Mona Riskalla, Susmita N Sarangi, Prakash Satwani, Anand Tandra, Kelly J Walkovich, John D Yee, Adi Zoref-Lorenz, Edward M Behrens

Faculty, Staff and Students Publications

Objective: Rheumatologic disease-associated hemophagocytic lymphohistiocytosis (HLH), a rare, life-threatening, systemic hyperinflammatory syndrome, occurs as a complication of underlying rheumatologic disease. Real-world evidence is lacking on emapalumab, a fully human monoclonal antibody that neutralizes the proinflammatory cytokine interferon-γ, approved for treating patients with primary HLH.

Methods: REAL-HLH, a retrospective medical chart review study conducted across 33 US hospitals, assessed real-world treatment patterns and outcomes in patients with HLH treated with one or more dose of emapalumab between November 20, 2018, and October 31, 2021. Data are presented for the subset of patients with rheumatologic disease-associated HLH.

Results: Fifteen of 105 patients …

Qm107, A Novel Cd148 (Rtp Type J) Activating Peptide Therapy For Treating Neovascular Age-Related Macular Degeneration, Samantha Arokiasamy, Michaela J M Balderstone, Faheem Shaik, Enrico Cristante, Thomas C Moseley, Akshay Madoo, Matteo Rizzi, James W Bainbridge, Konstantin Tsoyi, Ivan O Rosas, James R Whiteford, Giulia De Rossi

Faculty, Staff and Students Publications

Background and purpose: Angiogenesis is a pathological component of neovascular age-related macular degeneration. Current therapies, although successful, are prone to high levels of patient non-response and a loss of efficacy over time, indicating the need to explore other therapeutic avenues. We have shown that an interaction between syndecan-2 and the tyrosine phosphatase receptor CD148 (RTP Type J) results in the ablation of angiogenesis. Here we exploit this pathway to develop a peptide activator of CD148 as a therapy for neovascular age-related macular degeneration.

Experimental approach: We tested a peptide (QM107) derived from syndecan-2 in a variety of angiogenesis models and …

Prospective Analysis Of Liver Stiffness Measurement By Vibration Controlled Transient Elastography As A Predictor Of Outcomes In Biliary Atresia, Jean P Molleston, Nathan P Goodrich, Wen Ye, Daniel H Leung, Ronald J Sokol, Benjamin L Shneider, Children Force Outcomes Working Group

Faculty, Staff and Students Publications

No abstract provided.

Pragmatic Clinical Decision Support Trial Of Pre-Checked Default Orders: Monitoring Safety And Adverse Clinical Outcomes, John L Kilgallon, Michael Gannon, David W Bates, Adam Wright, Patricia Dykes, Christoph U Lehmann, Lipika Samal

Faculty, Staff and Students Publications

No abstract provided.

Expert Clinical Management Of Inflammatory Immune-Related Arthritis In Patients With Cancer Receiving Immune Checkpoint Inhibitors, Sebastian Bruera, Mar Riveiro-Barciela, Alexa Meara, Maria E Suarez-Almazor

Faculty, Staff and Students Publications

Introduction: Treatment guidelines for immune-related inflammatory arthritis (irAE-IA) in patients with cancer receiving immune checkpoint inhibitors (ICIs) are vague with respect to the use of specific agents. Patients are usually referred to rheumatologists for treatment. We conducted a survey of expert rheumatologists to determine current practices. We also assessed experts' views on the potential deleterious effects of various agents on tumor progression.

Methods: We conducted a survey of international experts in the treatment of irAE-IA, identified as members of collaborative scientific workgroups in this area. Experts were presented with a case of a patient with moderate irAE-IA and were asked …

The Internist's Post V.1 N.12, The University Of Texas Rio Grande Valley. School Of Medicine, Eunbee Cho, Jian Garcia Cruz, Ramon Elizondo Romo, Barbara Malaga-Espinoza, Carlos Alejos Aguero, Osiris Fernandez, Roque Mifuji Lira, Martha Solis, Cesar Gutierrez

School of Medicine Publications

No abstract provided.

The Efficacy Of Complementary And Alternative Medicines In Medical Dermatology: A Comprehensive Review, Promise Ufomadu, Bartley Joseph Gill, Ida Orengo, Theodore Rosen, Ikue Shimizu

Faculty, Staff and Students Publications

Background: In recent years, there has been a widespread patient use of complementary and alternative medicines (CAMs) for dermatological application, despite few RCT-level studies on these supplements. This creates a barrier for dermatologists and others in counseling patients who may be using or might be tempted to use these CAM agents. This review investigates various CAM modalities used by patients for medical dermatology, exploring their efficacy and toxicity profiles.

Methods: A comprehensive review was performed on the effectiveness of several CAMs utilized in medical dermatology by patients. A literature search was conducted using PubMed, Embase, Google Scholar, Web of Science, …

Hospice Patients In The Emergency Department: Challenging High-Risk Encounters With Unanswered Questions And Unquestioned Answers, Jason K Bowman, Joan M Teno, Kei Ouchi

Faculty, Staff and Students Publications

No abstract provided.

Disease Activity Of Rheumatoid Arthritis And Kidney Function Decline: A Large Prospective Registry Study, Sho Fukui, Wolfgang C Winkelmayer, Sara K Tedeschi, Javier Marrugo, Hongshu Guan, Leslie Harrold, Heather J Litman, Tomohiro Shinozaki, Daniel H Solomon

Faculty, Staff and Students Publications

Introduction: Chronic kidney disease (CKD) is a common comorbidity of rheumatoid arthritis (RA). The association of longitudinal RA disease activity with long-term kidney function has remained uncertain.

Method: We analysed a multicentre prospective RA registry in the USA from 2001 to 2022. The exposure was updated time-averaged Clinical Disease Activity Index (TA-CDAI) categories from study enrolment. The primary outcome was a longitudinal estimated glomerular filtration rate (eGFR) change. Secondary outcomes included developments of CKD stage G3a (eGFR< 60 mL/min/1.73 m2) and stage G3b (eGFR< 45 mL/min/1.73 m2). Results were adjusted for relevant time-fixed and time-varying covariates.

Results: 31 129 patients (median age: 58.0 years, female: 76.3%, median eGFR: 90.7 mL/min/1.73 m2) contributed 234 973 visits and 146 778 person-years …

Benefits And Harms Of Hepatocellular Carcinoma Screening Outreach In Patients With Cirrhosis: A Multicenter Randomized Clinical Trial, Amit G Singal, Darine Daher, Manasa Narasimman, Sruthi Yekkaluri, Yan Liu, Vanessa Cerda, Chaitra Banala, Aisha Khan, Minjae Lee, Karim Seif El Dahan, Caitlin C Murphy, Jennifer R Kramer, Ruben Hernaez

Faculty, Staff and Students Publications

Background: The value of hepatocellular carcinoma screening is defined by the balance of benefits from early tumor detection vs harms because of false-positive results. We evaluated the value of a mailed outreach strategy for hepatocellular carcinoma screening in patients with cirrhosis.

Methods: We conducted a multicenter pragmatic randomized clinical trial comparing mailed outreach for hepatocellular carcinoma screening (n = 1436) and usual care with visit-based screening (n = 1436) among patients with cirrhosis at 3 health systems from March 2018 to September 2021. Outcomes of interest were early stage hepatocellular carcinoma detection (ie, screening benefit) and diagnostic evaluation for false-positive …

Historical Demography And Species Distribution Models Shed Light On Speciation In Primates Of Northeast India, Mihir Trivedi, Kunal Arekar, Shivakumara Manu, Lukas F K Kuderna, Jeffrey Rogers, Kyle Kai-How Farh, Tomas Marques Bonet, Govindhaswamy Umapathy

Faculty, Staff and Students Publications

Past climate change is one of the important factors influencing primate speciation. Populations of various species could have risen or declined in response to these climatic fluctuations. Northeast India harbors a rich diversity of primates, where such fluctuations can be implicated. Recent advances in climate modeling as well as genomic data analysis has paved the way for understanding how species accumulate at a particular geographic region. We utilized these methods to explore the primate diversity in this unique region in relation to past climate change. To ascertain the population level changes, we inferred the demographic history of nine species of …

American Cochlear Implant Alliance Position Statement On Newborn Congenital Cytomegalovirus Screening, Megan Honor Pesch, Kevin David Brown, Amy L Birath, Gail J Demmler-Harrison, Cailtin Sapp, Anne Morgan Selleck, Alex D Sweeney

Faculty, Staff and Students Publications

It is estimated that 1 in every 200 US newborns has congenital cytomegalovirus (cCMV). Delayed identification of cCMV in newborns precludes timely intervention to mitigate sequelae of the infection such as hearing loss and other neurological complications. Newborn testing for cCMV enables appropriate diagnosis and intervention by multidisciplinary teams to properly manage the immediate sequelae of cCMV, avoid unnecessary additional testing that can result from delayed diagnosis, and monitor for future complications. It is the position of the American Cochlear Implant Alliance, the National CMV Foundation, and the American Academy of Otolaryngology-Head and Neck Surgery that universal newborn cCMV screening …

Task-Rest Reconfiguration Efficiency Of The Reward Network Across Adolescence And Its Association With Early Life Stress And Depressive Symptoms, Yoonji Lee, Justin P. Yuan, Anderson M. Winkler, Katharina Kircanski, Daniel Samuel Pine, Ian H. Gotlib

School of Medicine Publications

Objective

Adolescents face significant changes in many domains of their daily lives that require them to flexibly adapt to changing environmental demands. To shift efficiently among various goals, adolescents must reconfigure their brains, disengaging from previous tasks and engaging in new activities.

Method

To examine this reconfiguration, we obtained resting-state and task-based fMRI scans in a community sample of 164 adolescents. We assessed the similarity of functional connectivity (FC) of the reward network between resting state and a reward processing state, indexing the degree of reward network reconfiguration required to meet task demands. Given research documenting relations among reward network …

Integration Of Community Health Workers Into Palliative Care Teams: A Scoping Review, Angela Kroeze Visser, Anne Pithan, Sabina Kupershmidt, Denyelle B. Kenyon, Susan E. Puumala

Faculty Work Comprehensive List

Background:

Rural communities, like other places in the United States, face a growing need for palliative care. Community health workers (CHWs) are one potential way to expand the ability to provide palliative care. This scoping review explores what is known about CHWs involved in palliative care teams in the United States.

Objective:

This scoping review is intended to outline current evidence related to best practices and factors that lead to the integration of CHWs into palliative care teams.

Methods:

A scoping review was conducted between June 2022 and April 2023 using 3 databases (CIHAHL, ScienceDirect, and PubMed) to identify included …

Poured Out On Your Sons And Daughters: Pneumatologically Shaped Pedagogical Practices For Engaging Children In Congregational Worship, Angela Perigo, Jeremy Perigo

Faculty Work Comprehensive List

From young children to elders in the community, the Holy Spirit’s empowering presence is indiscriminate of age, ability, gender, culture, or status. Many communities continue to wrestle with the pastoral and practical implications of welcoming children into worship as full, distinct participants, yet within the biblical narrative, children are included as full participants in experiencing the Spirit’s gifts and empowerment and encountering God’s dynamic presence. Emerging from the discipline of practical theology and a review of New Testament pneumatology from Acts 2 and 1 Corinthians 12, this paper argues for the full inclusion of children within the church’s worship life …

Development Of Soil Survey Methods For Urban Areas, Kohinoor Begum

Dissertations, Theses, and Capstone Projects

Urban soils are the foundation of urban ecosystems and play a vital role in long-term urban sustainability and resiliency. Accurate soil surveys of urban areas should be done at higher resolution since extensive human activities often result in urban soil being highly disturbed and spatially variable. Besides heterogeneity, one of the unique and challenging aspects of urban soil is the nature and properties of its organic carbon with a significant percentage of black carbon (a particulate product of incomplete combustion), which is less biologically active. Thus, in order to determine the ability of a soil to support biological activity and …

Visualizing The Rise Of American Women's Soccer, Hoi Wah Tang

Dissertations, Theses, and Capstone Projects

The rise of American women’s soccer is a compelling narrative of determination, talent, and triumph on the global stage. From the inaugural FIFA Women’s World Cup in 1991 to the ongoing dominance of the U.S. Women’s National Team (USWNT), this journey encapsulates not only athletic excellence but also the broader struggles for equality, representation, and respect in sports.

This project aims to bring this story to life by presenting a rich tapestry of data visualizations, timelines, and multimedia elements that showcase key moments, players, and milestones. Through engaging graphics and interactive features, users will explore how the sport evolved, the …

Chatgpt Didn’T Write This: Evaluating The Impact Of Llms With A Case Study In Grading Cuny Language Immersion Program Student Essays, Benjamin Inbar

Dissertations, Theses, and Capstone Projects

This study evaluates the capabilities and limitations of large language models (LLMs), specifically OpenAI’s ChatGPT-4o, in grading essays from students in the City University of New York’s Language Immersion Program. The program serves English language learners with diverse linguistic and demographic backgrounds, offering intensive language instruction to prepare students for academic success in college. Using a dataset of 30 pre- and post-program essays scored by program instructors and ChatGPT-4o under three paradigms, this research explores the alignment between human and AI-generated scores across five rubric-based competency areas. Findings reveal that ChatGPT-4o aligns moderately with human grading, with the strongest agreement …

Beyond The Sum: A Network Analysis Of Adverse Childhood Experiences And Behavioral Outcomes In Justice-Involved Youth, Jennifer Yang

Dissertations, Theses, and Capstone Projects

This dissertation examines gender-specific patterns of adverse childhood experiences (ACEs) among justice-involved youth using network analysis. Despite experiencing higher rates of childhood adversity, female youth show lower recidivism rates than males, presenting an empirical paradox. Using a sample of 19,454 justice-involved youth (75% male), this study applies novel network methods to understand how ACEs and behavioral outcomes are organized across gender. Findings reveal distinct network architectures: female youth maintain more integrated but vulnerable networks, while males show more compartmentalized but stable structures. Female recidivists demonstrate systematic network destabilization when compared to non-recidivists, characterized by a 39% reduction in network density, …

Decades Of Division: Analyzing Hate Crimes In The Usa (1991–2022), Sangeeth Sajan Baby

Dissertations, Theses, and Capstone Projects

This project comprehensively analyses hate crime data in the United States, leveraging advanced data analysis and visualization techniques to unmask patterns and insights. By utilizing datasets of criminal offenses reported by law enforcement agencies such as the FBI, this study explores the dynamics of hate crimes across racial, religious, gender, and sexual orientation groups. The analysis reveals key findings, including the disproportionate targeting of African Americans and LGBTQ+ individuals, the prevalence of hate crimes in specific locations like residences and educational institutions, and the consistent patterns of attack types and locations across different racial groups. Analysis of crime data over …

Quantifying Educational Impacts Under The Nypd's Stop-And-Frisk Era, Matthew T. Stanton

Dissertations, Theses, and Capstone Projects

This project examines the educational and economic impacts of the New York Police Department's "Stop, Question, and Frisk" (SQF) program, implemented predominantly under "Operation Impact" from 2003 to 2022. Using data from the NYPD and the American Community Survey, the study explores correlations between high rates of stop-and-frisk encounters and reduced educational attainment among targeted demographics, primarily Black and Hispanic young men. It contextualizes the socioeconomic consequences of SQF policies, including their effect on lifetime earnings and community trust. The project highlights the limitations of data correlation, advocates for further longitudinal and qualitative studies, and suggests frameworks for mitigating inequities …

Beauty Comes With A Price: But How Much Is It Worth It, Fabliha Afia

Dissertations, Theses, and Capstone Projects

The global skincare market, valued at 104.24 billion dollars in the year 2022, is very heterogeneous, ranging from prestige brands to more drugstore types. Even when the same key ingredients are present, the latter often sells for much higher due to branding and packaging and the aura of prestige created. This capstone project entitled "Beauty comes with a price: but how much is it worth?" investigates if such higher costs are justified due to superior quality or are driven by non-functional factors. It systematically compared the high-end versus drugstore skincare products in categories like sunscreens, serums, and exfoliants with respect …

Caedmon Records & The Power Of Youth: How Audiobooks Revolutionized Children’S Literature, Faihaa Khan

Dissertations, Theses, and Capstone Projects

The first known spoken-word recording was introduced to the world by Thomas Edison through the invention of the phonograph. Originally intended for a visually impaired audience to read without exertion, the first known recording was a recitation of the English nursery rhyme “Mary Had a Little Lamb" by Edison himself. The inclusion of a children’s nursery rhyme since the genesis of such an invention has become significant in observing the rise and success of the audiobook industry and its direct impact in increasing literacy proficiency in children.

Interactions between children’s literature and the history of the audiobook have been many …

Freedom Pedagogy: Black Educators In The Urban North During The Nineteenth And Early Twentieth Centuries, Milagros Seraus-Roache

Dissertations, Theses, and Capstone Projects

Black educational history has been told through a predominantly Southern lens. This dissertation highlights the experiences of Black educators in the urban North during the nineteenth and early twentieth centuries. Northern Black educators confronted the challenges of freedom—including the constant need to protect it—using a set of approaches influenced by the various intersecting social movements and intellectual currents of their day. While these educators represented a small minority of African Americans, their contributions were profound, leaving legacies that provide a lens for understanding and improving issues facing urban Black youth and their communities today.

In the absence of a comprehensive …

Silver-Alloyed Cigs Thin-Film Solar Cells On Flexible Stainless-Steel Substrate, Zhi Huang

Dissertations, Theses, and Capstone Projects

Our dissertation demonstrates the optimization of ACIGS (Ag-Cu-In-Ga-Se) thin-film solar cells, achieving an efficiency of 20.4% through the combined effects of silver incorporation and alkali metal post-deposition treatment (PDT). The incorporation of 2.8% Ag into the CIGS lattice enhanced crystal quality, reduced disorder, and widened the bandgap by 0.103 eV, as evidenced by a significant reduction in Urbach energy. These improvements resulted in stronger light absorption, increased carrier generation, and enhanced photovoltaic parameters, including a short-circuit current density Jsc of 35.31 mA/cm², an open-circuit voltage Voc of 0.74 V, and a fill factor (FF) of 75.8%. PDT using rubidium fluoride …

Sinusitis And Rhinitis Among Us Veterans Deployed To Southwest Asia And Afghanistan After September 11, 2001, Jennifer Maccarone, Carrie A Redlich, Andrew Timmons, Anna M Korpak, Nicholas L Smith, Karen S Nakayama, Coleen P Baird, Paul Ciminera, Farrah Kheradmand, Vincent S Fan, Jaime E Hart, Petros Koutrakis, Ware G Kuschner, Octavian C Ioachimescu, Michael Jerrett, Philippe R Montgrain, Susan P Proctor, Christine H Wendt, Cherry Wongtrakool, Emily S Wan, Paul D Blanc, Eric Garshick

Faculty, Staff and Students Publications

BACKGROUND: Post-9/11 veterans were exposed to environmental and occupational pollutants during deployment.

OBJECTIVE: Our aim was to determine associations between deployment-related exposures and sinusitis and rhinitis.

METHODS: Between April 2018 and March 2020, veterans with land-based deployment after 9/11 who were living within 25 miles of 6 Department of Veteran Affairs medical centers were randomly chosen by using a Defense Manpower Data Center roster. Participants completed interviewer-administered questionnaires, which included a 32-item deployment exposure battery and self-report of rhinitis and health professional-diagnosed sinusitis. Exposure categories included burn pit smoke, combustion engine exhaust/ground dust, other open combustion sources, toxicants, and military …