Digital Commons Network^™

Plasma Proteomic Characterization Of Motoric Cognitive Risk And Mild Cognitive Impairment, Pascal Schlosser, Priya Palta, Kevin J Sullivan, Adrienne Tin, B Gwen Windham, Rebecca F Gottesman, Nir Barzilai, Sofiya Milman, Joe Verghese, Josef Coresh, Keenan A Walker

Faculty, Staff and Student Publications

INTRODUCTION: Motoric cognitive risk (MCR) is a pre-dementia syndrome characterized by mobility and cognitive dysfunction. This study conducted a proteome-wide study of MCR and compared the proteomic signatures of MCR to that of mild cognitive impairment (MCI).

METHODS: Participants were classified as MCR using a memory questionnaire and 4-meter walk. We measured 4877 plasma proteins collected during late-life and midlife. Multivariable logistic regression related each protein to late-life MCR/MCI. MCR-associated proteins were replicated internally at midlife and in an external cohort.

RESULTS: Proteome-wide analysis (n = 4076) identified 25 MCR-associated proteins. Eight of these proteins remained associated with late-life MCR …

A Qualitative Assessment Of Changes In Occupational Exposures Among Healthcare Facility Workers, Laura E Mitchell, Inkyu Han, Jan-Paul Zock, Paul K Henneberger, Riddhi Patel, Joy De Los Reyes, George L Delclos

Faculty, Staff and Student Publications

Adult-onset asthma, notably prevalent among healthcare professionals, especially nurses, is often attributed to occupational factors such as exposure to cleaning agents. Studies consistently underscore the substantial role of such exposure in work-related asthma among hospital staff. We aimed to (a) identify and characterize current practices in cleaning and aerosolized medication administration; (b) assess changes in practices since a similar 2003 study of Texas healthcare workers; and (c) identify factors contributing to diverse exposures within healthcare job categories. We conducted focus groups with 38 participants in 6 healthcare settings, analyzing current practices, changes since 2003, and factors contributing to exposure diversity. …

Phase Of The Seabed Frequency-Domain Reflection Coefficient: Measurements And Modeling, Charles W. Holland

Electrical and Computer Engineering Faculty Publications and Presentations

The phase of the seabed frequency-domain reflection coefficient potentially contains valuable information on the geoacoustic properties in a layered/refracting seabed. However, heretofore, the phase has not been exploited. Measurements of phase are presented in an area of thick mud at the New England Mud Patch. In addition, a model is presented along with the modeling results. While this is only a first step towards understanding the potential value of exploiting the phase, it seems clear that in some instances, the phase not only contains valuable geoacoustic information, but carries a higher information content than the magnitude.

Introduction To The Special Issue On Verification And Validation Of Source And Propagation Models For Underwater Sounda), Kathleen J. Vigness-Raposa, Klaus Lucke, Michael A. Ainslie, Michele B. Halvorsen, Christ A. F. De Jong, Stanley J. Labak, Martin Siderius

Electrical and Computer Engineering Faculty Publications and Presentations

This joint Special Issue of JASA and JASA Express Letters focuses on underwater sound source and propagation modelling, both of ambient sound as well as sources of relevance to possible effects of sound on aquatic life, and corresponding acoustical metrics. Combining information on the sound field with information on a dose-effect relationship enables estimation of the potential effects. The Special Issue presents a collection of eighteen articles on the following topics: (1) verification of source and propagation models, (2) validation of source and propagation models, and (3) bioacoustical metrics for assessment of the risk of environmental effects. This special issue …

Regulation Of Artificial Intelligence In Healthcare: Clinical Laboratory Improvement Amendments (Clia) As A Model, Dean F Sittig

Faculty, Staff and Student Publications

Objectives: To assess the potential to adapt an existing technology regulatory model, namely the Clinical Laboratory Improvement Amendments (CLIA), for clinical artificial intelligence (AI).

Materials and methods: We identify overlap in the quality management requirements for laboratory testing and clinical AI.

Results: We propose modifications to the CLIA model that could make it suitable for oversight of clinical AI.

Discussion: In national discussions of clinical AI, there has been surprisingly little consideration of this longstanding model for local technology oversight. While CLIA was specifically designed for laboratory testing, most of its principles are applicable to other technologies in patient care. …

Extended State Infrastructure Power In An Age Of Networked Competition: The Cases Of Thailand And Taiwan, Sol Andrew Stokols, Justin Kollar

Research Collection College of Integrative Studies

Scholars have highlighted the emergence of infrastructure as a key domain in the struggle over network centrality in what some call the ‘Second Cold War’ between the U.S. and China. We qualify this ‘infrastructural turn’ by drawing attention to the contingent nature of state infrastructural power as depending on key domestic firms that often serve as intermediaries between domestic infrastructure and global supply chains or international partners. Utilising empirical case studies based on field research conducted between 2021 and 2023 in Thailand and Taiwan, we analyse the ways in which state infrastructure power is exercised through strategic negotiation between national …

Orchestra Librarians’ Responses In The Time Of Covid-19: A Qualitative Study Of Symphony Orchestra Librarians Around The Globe, Patrick Lo, Hermina G.B. Anghelescu

School of Information Sciences Faculty Research Publications

The COVID-19 crisis has disrupted the performing arts ecosystem worldwide, with an even more severe impact on classical orchestras. This study examines how 19 seasoned, established orchestra librarians and their parent organizations worldwide experienced and responded to the COVID-19 pandemic. The study examines similarities and differences in their professional practices and experiences of coping with pandemic-related disruptions. The study sheds new light on how orchestra librarians' practices changed, along with their resilience, adaptability, sense of self-worth, and career fulfilment during COVID-19,in the context that none were furloughed or made redundant. The paper also discusses the impact of pandemic restrictions on …

Stealth Navigation With Ifuse-Torq Implant For Sacroiliac Joint Fusion Technique Guide., Jia Bao Lin, Bryan L Demyan, Logan M Bushnell, Morgan T Turnow, Benjamin C Taylor

Surgery Articles

INTRODUCTION: Dysfunction of the sacroiliac (SI) joint exists in nearly one-third of patients with lower back pain. There are nuances in diagnosing SI joint dysfunction with a combination of physical exam maneuvers and intra-articular injections. The management of patients with SI joint pain can include posterior pelvic fixation, which traditionally has been described using fluoroscopy to obtain safe placement of implants.

CASE REPORT: In this technique guide, we would like to introduce a novel technique of using Stealth navigation to facilitate SI fusion with the iFuse-TORQ implant.

CONCLUSION: SI dysfunction is a common cause of low back pain that can …

Jane Goodall’S Integration Of Science And Spirituality, Estella Elpers

Father Jack McGrath, S.M., Research Award Presentations

Estella Elpers is a recipient of the Father Jack McGrath, S.M., Award for Research in Catholic Intellectual Traditions.

Police Sexual Violence As Psychological Detention: Making Full Use Of Charter Rights, Sandrine Ampleman-Tremblay

Dalhousie Law Journal

This paper argues that individual responsibility has been overemphasized in cases of sexual violence by police. The fact that police officers are part of a state system calls for an examination of the role of the state in contributing to the risks of sexual violence by police. The paper thus contends that Canadian law requires methods to address state blame in such cases. It analyses psychological detention under section 9 of the Canadian Charter of Rights and Freedoms as a means to draw a connection between police powers, sexual violence, and state blame. The suggested section 9 interpretation builds on …

Application Of Convolutional Neural Network For Seismic Event Classification: Impact Of Dataset Quality, Distribution, And Human-In-The-Loop Feedback, Yanwei Zhang, Stephen S. Gao, Xiaoyi Fan, Shaohui Zhou, Junhao Qu

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Convolutional neural networks (CNNs) have gained popularity in geophysical research due to their exceptional performance in various areas. However, achieving reliable results with CNNs typically requires a significant amount of high-quality data for training. In this study, we develop a CNN to classify natural earthquakes, mine collapses, and explosions using seismic waveforms from 287 stations in Shandong Province, China. The dataset comprises 1035 earthquakes, 159 mine collapses, and 586 explosions. To address the impact of unreliable measurements, we employ cross validation to screen, manually correct, or discard measurements with inconsistent labels assigned by human experts and CNN. By refining the …

Influence Of Temperature, Oxygen Partial Pressure, And Microstructure On The High-Temperature Oxidation Behavior Of The Sic Layer Of Triso Particles, Visharad Jalan, Adam Bratten, Meng Shi, Tyler Gerczak, Haiyan Zhao, Jonathan D. Poplawsky, Xiaoqing He, Grant Helmreich, Haiming Wen

Materials Science and Engineering Faculty Research & Creative Works

Tri structural isotropic (TRISO)-coated fuel particles are designed for use in high-temperature gas-cooled nuclear reactors, featuring a structural SiC layer that may be exposed to oxygen-rich environments over 1000 °C. Surrogate TRISO particles were tested in 0.2–20 kPa O2 atmospheres to observe the differences in oxidation behavior. Oxide growth mechanisms remained consistent from 1200–1600 °C for each PO2, with activation energies of 228 ± 7 kJ/mol for 20 kPa O2 and 188 ± 8 kJ/mol for 0.2 kPa O2. At 1600 °C, kinetic analysis revealed a change in oxide growth mechanisms between 0.2 and 6 kPa O2. In 0.2 kPa …

Elevated Temperature Performance: Arc-Jet Testing Of Carbon Fiber Reinforced Zrb2 Bars Up To 2200 °C For Strength Retention Assessment, D. Sciti, A. Vinci, L. Zoli, P. Galizia, M. Mor, W. Fahrenholtz, S. Mungiguerra, R. Savino, A. M. Caporale, A. Airoldi

Materials Science and Engineering Faculty Research & Creative Works

For the first time, ultra-high temperature ceramic matrix composite bars were tested inside an arc-jet facility to investigate the impact of oxidation damage on strength retention. The composite bars, which were based on a ZrB2 / SiC matrix reinforced with 45 vol% carbon fibers, were produced by slurry impregnation and sintering. The first batch was tested under 3-point (pt) bending, and two additional batches were exposed to plasma of dissociated air up to a temperature of 2200 °C for 2 min or 2.2 min and then subjected to 3-pt bending. More than 75% of the initial strength was retained even …

A Living Feminist Postdevelopmental Lexicon For Early Education, Mindy Blaise, Veronica Pacini-Ketchabaw

Research outputs 2022 to 2026

Expanding the important body of work that addresses child development’s limitations and responding to the ecological crisis that threatens the future of life on Earth, this article proposes a living feminist postdevelopmental lexicon. The lexicon introduces 26 concepts that together challenge the theory/practice divide, disrupt Cartesian modes of subjectivity, reorient taken-for-granted ideas as problematic in early education, open up early education to inquiries that respond to the political and ethical questions of our milieu, and generate conditions for creative, inventive, thoughtful, and ethical projects. The paper invites readers to engage with and creatively add to the lexicon, making it an …

A Micro-Computed Tomographic Evaluation Of Dentine Thicknesses Of First Molar Roots: A Review Of The Literature With Illustrative Cases, Marisca Meyer, Casper Jonker, Sandeepa Rajbaran-Singh, Anna Catherina Oettlé

Peninsula Dental School

Thin dentinal walls of first molars can significantly impact the success and outcomes of endodontic procedures, including root canal treatment. Root canal treatment is commonly performed on first molars, which are prone to decay due to their early eruption and complex occlusal structure. The treatment entails a series of mechanical and chemical disinfection techniques where the root canal spaces are enlarged and can be compromised by perforations leading to infection, inflammation, and eventual tooth loss. The thinner the dentine, the greater the likelihood of perforation. ‘Danger zones’ have been identified as the distal aspect of mesial/mesiobuccal roots and the mesial …

Development Of 24-Hour Rhythms In Cortisol Secretion Across Infancy: A Systematic Review And Meta-Analysis Of Individual Participant Data, Laura Kervezee, Michelle Romijn, Kirsten N.G. Van De Weijer, Britney S.J. Chen, George L. Burchell, Marieke S. Tollenaar, Marcela Tamayo-Ortiz, Lauren E. Philbrook, Carolina De Weerth, Yang Cao, Joost Rotteveel, Rina D. Eiden, Rima Azar, Nicole R. Bush, Adina Chis, Grazyna Kmita, Melissa W. Clearfield, Roseriet Beijers, Michael Gröschl, Stefan A. Wudy, Andries Kalsbeek, Evalotte Mörelius, Martijn J.J. Finken

Research outputs 2022 to 2026

Context: In adults, cortisol levels show a pronounced 24-hour rhythm with a peak in the early morning. It is unknown at what age this early-morning peak in cortisol emerges during infancy, hampering the establishment of optimal dosing regimens for hydrocortisone replacement therapy in infants with an inborn form of adrenal insufficiency. Objective: We aimed to characterize daily variation in salivary cortisol concentration across the first year of life. Methods: We conducted a systematic review followed by an individual participant data meta-analysis of studies reporting on spontaneous (ie, not stress-induced) salivary cortisol concentrations in healthy infants aged 0-1 year. A one-stage …

Sparse Seagrass Meadows Are Critical Dugong Habitat: A Novel Rapid Assessment Of Habitat-Wildlife Associations Using Paired Drone And In-Water Surveys, Nicole E. Said, Christophe Cleguer, Paul Lavery, Amanda J. Hodgson, Connor Gorham, Julian A. Tyne, Ankje Frouws, Simone Strydom, Johnny Lo, Holly C. Raudino, Kelly Waples, Kathryn Mcmahon

Research outputs 2022 to 2026

Understanding the fine-scale behavioural and feeding ecology of marine megafauna is imperative for effective management of their habitat areas; however, obtaining the relevant data can be both costly and challenging. Here we integrate the use of small drones for dugong surveys with underwater benthic habitat assessment techniques at the local spatial scale (∼30 km2), to determine the drivers of dugong (Dugong dugon) distribution across three locations in the Pilbara, Western Australia. Paired assessment data was collected three times over two years. Benthic habitat (percent cover), seagrass nutritional quality and environmental parameters (temperature, water clarity, water current, water depth) were tested …

Establishment Of The Nichols Strain As The Type Strain Of Treponema Pallidum, Steven J Norris

Faculty, Staff and Student Publications

In this article, it is proposed that the Nichols strain of Treponema pallidum be established as the type strain. T. pallidum was first identified as the causative agent of syphilis in 1905, and the Nichols strain was isolated in 1912 by inoculation of a rabbit with cerebrospinal fluid from a patient with neurosyphilis. The Nichols strain has been maintained by serial passage in rabbits for over a century, and historically most studies of T. pallidum have been conducted using this strain. In recent years, a procedure for continuous in vitro culture of T. pallidum in a tissue culture system has …

Looking Out For Danger: Theoretical And Empirical Issues In Translating Human Attention Bias Tasks To Assess Animal Affective States, Sarah Kappel, Sarah Collins, Michael Mendl, Carole Fureix

School of Biological and Marine Sciences

Understanding animal emotional (affective) state is highly relevant to various disciplines (e.g., animal welfare, neuroscience, comparative psychology), and has been significantly advanced by translating affect-induced cognitive bias paradigms rooted in human psychology to non-human animal studies. Attention bias (i.e., preferential attention allocation, AB) tests are increasingly used as more practical substitutes to commonly used judgement bias tests. Yet, evidence that AB reflects affective valence in animals is still limited. We review in-depth the concept of attention and AB described in humans and discuss utilising human-derived AB paradigms for measuring animal affective states. We describe key concepts and functions of attention …

Coevolution Of Soes And The Chinese Economy: The Roles Of Soe Heterogeneity From The Institutional, Strategic, And Organizational Perspectives, Kenneth G. Huang, Runtian Jing, Jun Xia, Man Zhang, Weiguo Zhong, David Zhu

Research Collection Lee Kong Chian School Of Business

State-owned enterprises (SOEs) in China play a critical role in national economic development and the country's positioning on the global stage. Chinese SOEs have undergone substantial transformations from traditional government-run entities to a variety of corporate forms exhibiting different levels of state involvement. Despite their substantial influence, the internal diversity of SOEs – from wholly state-owned to mixed-ownership – has not been thoroughly examined. This paper provides an overview of SOEs' critical roles in the Chinese economy, the relationship between SOEs and privately owned enterprises (POEs), and the challenges of SOEs in different stages of Chinese economic development. It then …

Covid-19- In Children Evidence For Treatment With Remdesivir, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.

Critical Picture Book Literacy, Caitlin Stewart, Heather Koopmans

Faculty and Staff Publications – Milner Library

This study sought to revisit established definitions of critical visual literacy and determine how this concept could be re-envisioned specifically for picture books when informed by the approaches of teacher education students who had received limited prior formal instruction on critiquing visual texts. Seventeen sophomore elementary education students engaged in written self-discourse around the visual narrative of Milo Imagines the World written by Matt de la Peña and illustrated by Christian Robinson where they generated questions and answers critically engaging with the visuals. These participants’ responses underwent thematic analysis informed by grounded theory which uncovered a collective definition for critical …

Impurity Behavior In Cast Copper Anodes: Implications For Electrorefining In A Circular Economy, Agustin Morales-Aragon, Daniel Sánchez-Rodas, Guillermo Ríos, Michael S. Moats

Materials Science and Engineering Faculty Research & Creative Works

The behavior of impurities in cast copper was investigated to simulate production with increased utilization of secondary sources within the framework of a circular economy. The incorporation of impurities, particularly Ni, Sn, and Sb, from recycled Cu may significantly impact the electrorefining process. In this study, commercial anodes were doped with Ni, Sn, and Sb concentrations of 2500–6500 g/t, 300–900 g/t, and 450–950 g/t, respectively. Anode concentrations of Pb and Bi were maintained at 1000 g/t and 350 g/t, respectively. As concentrations were examined at two levels, 860 or 1700 g/t, depending on the commercial anode used to create the …

Research On Wireless Monitoring System For Internal Temperature Field Of Coal Gangue Mountain, Xiaofei Liu, Chunhao Liang, Jifa Qian, Xiaolin Li, Xuemei Li, Baoli Li, Guang Xu, Bin Zhou

Mining Engineering Faculty Research & Creative Works

In the long-term accumulation process, coal gangue can lead to severe consequences such as spontaneous combustion and explosions due to external factors. Additionally, the coal gangue that ignites spontaneously significantly pollutes the land and groundwater, causing serious risks to the health and safety of individuals living and working in the vicinity. Therefore, to mitigate the risk of spontaneous combustion resulting from the long-term accumulation of coal gangue, a monitoring system based on LoRa wireless communication technology is proposed to collect and monitor the internal temperature of coal gangue mountains in real time. In the laboratory, active temperature rise monitoring was …

Blast Tube Design: How Shape And Size Influence The Resultant Shock Wave, R. L. Bauer, C. E. Johnson

Mining Engineering Faculty Research & Creative Works

Shock tubes and tunnels are often used in research settings as a way of producing high pressure shock waves in a smaller footprint or without the use of explosives. However, there is no standard geometric design across laboratories. Peak pressure is a significant parameter for characterizing a shock wave. However, different tube configurations could also affect parameters such as impulse and duration, yet no research has investigated how the scale of the tube affects the overall waveform shape. To understand the implications of shock tube design, tubes with a constant length to diameter ratio were evaluated to determine how tube …

Rheology And Early-Age Structure Development In Binary And Ternary Blends Modified With Novel Graphene Types, Sahil Surehali, Collin Gustafson, Sayee Srikarah Volaity, Ranjith Divigalpitiya, Aditya Kumar, Narayanan Neithalath

Materials Science and Engineering Faculty Research & Creative Works

Interest in the use of graphene to enhance the properties of cementitious materials is growing, but major impediments in implementation are the cost of graphene and changes in binder rheology attributable to these nanomaterials. This study explores the influence of novel, cost-effective, environment-friendly, and mass-producible graphene on the rheology and early-age structure development of cementitious binders. Two novel graphene types—fractal graphene (FG) and reactive graphene (RG)—are used in plain cement mixtures as well as those containing 30 % (by mass) of fly ash and/or limestone powder, at low dosages of ≤0.02 % by mass of binder. The early- and later-age …

Effects Of Gypsum And Limestone On Early-Age Hydration And Strength Optimization In Belite Calcium Sulfoaluminate Cement, Sai Akshay Ponduru, Bryan K. Aylas-Paredes, Taihao Han, Advaith Neithalath, Narayanan Neithalath, Gaurav Sant, Aditya Kumar

Materials Science and Engineering Faculty Research & Creative Works

Belite calcium sulfoaluminate cement (CSAB), an alternative to Portland cement, exhibits excellent strength at both early and later ages. However, due to its high belite content, the carbon reduction from this type of cement is not sufficient when compared to other alternative cements. To further enhance CSAB's sustainability, this study investigates the performance of CSAB when partially replaced by low-carbon mineral additives (i.e., limestone and gypsum). The primary objective is to identify the optimal mixture design by incorporating gypsum and limestone to formulate a sustainable binder that maintains high compressive strength. The CSAB is replaced (with both additives) by up …

Controlling Structural Phases Of Sn Through Lattice Engineering, Chandima Kasun Edirisinghe, Anjali Rathore, Taegeon Lee, Daekwon Lee, An Hsi Chen, Garrett Baucom, Eitan Hershkovitz, Anuradha Wijesinghe, Pradip Adhikari, Sinchul Yeom, Hong Seok Lee, Hyung Kook Choi, Hyunsoo Kim, Mina Yoon

Physics Faculty Research & Creative Works

Topology and superconductivity, two distinct phenomena, offer unique insight into quantum properties and their applications in quantum technologies, spintronics, and sustainable energy technologies. Tin (Sn) plays a pivotal role here as an element because of its two structural phases, α-Sn exhibiting topological characteristics and β-Sn showing superconductivity. Here, we demonstrate precise control of these phases in Sn thin films using molecular beam epitaxy with systematically varied lattice parameters of the buffer layer. The Sn films exhibit either β-Sn or α-Sn phases as the buffer layer's lattice constant varies from 6.10Å to 6.48Å, spanning the range from GaSb (like InAs) to …

Helicity Modulus And Chiral Symmetry Breaking For Boundary Conditions With Finite Twist, Gaurav Khairnar, Thomas Vojta

Physics Faculty Research & Creative Works

We study the response of a two-dimensional classical XY model to a finite (noninfinitesimal) twist of the boundary conditions. We use Monte Carlo simulations to evaluate the free energy difference between periodic and twisted-periodic boundary conditions and find deviations from the expected quadratic dependence on the twist angle. Consequently, the helicity modulus (spin stiffness) shows a nontrivial dependence on the twist angle. We show that the deviation from the expected behavior arises because of the mixing of states with opposite chirality which leads to an additional entropy contribution in the quasi-long-range ordered phase. We give an improved prescription for the …

Challenges And Opportunities For Data Integration To Improve Estimation Of Migratory Connectivity, Jeffrey A. Hostetler, Emily B. Cohen, Christen M. Bossu, Amy L. Scarpignato, Kristen Ruegg, Andrea Contina, Clark S. Rushing, Michael T. Hallworth

School of Integrative Biological & Chemical Sciences Faculty Publications

1. Understanding migratory connectivity, or the linkage of populations between seasons, is critical for effective conservation and management of migratory wildlife. A growing number of tools are available for understanding where migratory individuals and populations occur throughout the annual cycle. Integration of the diverse measures of migratory movements can help elucidate migratory connectivity patterns with methodology that accounts for differences in sampling design, directionality, effort, precision and bias inherent to each data type.
2. The R package MigConnectivity was developed to estimate population-specific connectivity and the range-wide strength of those connections. New functions allow users to integrate intrinsic markers, tracking and long-distance …