Digital Commons Network^™

Variants In Lrrc7 Lead To Intellectual Disability, Autism, Aggression And Abnormal Eating Behaviors., Jana Willim, Daniel Woike, Daniel Greene, Sarada Das, Kevin Pfeifer, Weimin Yuan, Anika Lindsey, Omar Itani, Amber L. Böhme, Debora Tibbe, Hans-Hinrich Hönck, Fatemeh Hassani Nia, Undiagnosed Diseases Network, Michael Zech, Theresa Brunet, Laurence Faivre, Arthur Sorlin, Antonio Vitobello, Thomas Smol, Cindy Colson, Kristin Baranano, Krista Schatz, Allan Bayat, Kelly Schoch, Rebecca Spillmann, Erica E. Davis, Erin Conboy, Francesco Vetrini, Konrad Platzer, Sonja Neuser, Janina Gburek-Augustat, Alexandra Noel Grace, Bailey Mitchell, Alexander Stegmann, Margje Sinnema, Naomi Meeks, Carol Saunders, Maxime Cadieux-Dion, Juliane Hoyer, Julien Van-Gils, Jean-Madeleine De Sainte-Agathe, Michelle L. Thompson, E Martina Bebin, Monika Weisz-Hubshman, Anne-Claude Tabet, Alain Verloes, Jonathan Levy, Xenia Latypova, Sönke Harder, Gary A. Silverman, Stephen C. Pak, Tim Schedl, Kathleen Freson, Andrew Mumford, Ernest Turro, Christian Schlein, Vandana Shashi, Hans-Jürgen Kreienkamp

Manuscripts, Articles, Book Chapters and Other Papers

Members of the leucine rich repeat (LRR) and PDZ domain (LAP) protein family are essential for animal development and histogenesis. Densin-180, encoded by LRRC7, is the only LAP protein selectively expressed in neurons. Densin-180 is a postsynaptic scaffold at glutamatergic synapses, linking cytoskeletal elements with signalling proteins such as the α-subunit of Ca²⁺/calmodulin-dependent protein kinase II. We have previously observed an association between high impact variants in LRRC7 and Intellectual Disability; also three individual cases with variants in LRRC7 had been described. We identify here 33 individuals (one of them previously described) with a dominant neurodevelopmental disorder due …

Unesco, Mining Heritage And The Scalar Sustainability Of Tourism Geographies At Industrial World Heritage Sites, Mark A. Rhodes, Kathryn L. Hannum

Michigan Tech Publications

Purpose: Industrial heritage works within a world of contradictions, contentions and scalar liminality. Archaeologists and historians focus upon oral histories and discourses of tangible and intangible memory and heritage while planners and economists see industrial World Heritage, in particular, as a marketing ploy to redevelop deindustrialized spaces. Within this liminality, we explore the potential for geographical perspectives to solder such contradictions into transdisciplinary heritage assessments and tourism contexts. How might the spatial tools of landscape and scalar analyses expose alternative and sustainable futures within broader patterns of industrial heritage management and consumption?

Design/methodology/approach: Using three comparative cases, interview and landscape …

Community College Students’ Perceptions Of Hybrid Class Elements That Affect Their Academic Achievement, Jennifer Lynn Horvath

Walden Dissertations and Doctoral Studies

Despite research and advances in hybrid learning in the field of education, the gap lies in the lack of research focusing on community college students' perceptions of which elements of hybrid classes significantly impact their academic achievement. This problem, often leading to lower completion rates and higher attrition, was particularly important to community colleges supporting rural populations. The purpose of this basic qualitative study was to determine community college students’ perceptions of hybrid class elements that affected their academic achievement. Cognitive load theory served as the foundation for a conceptual framework, enabling the interpretation of student perceptions as manifestations of …

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

The Influence Of Hip Position On Neck Kinematics And Muscle Activity In Healthy And Non-Specific Neck Pain Subjects, Enrique Lopez, Everett Lohman, Noha Daher, Mansoor Alameri, Robert Dudley

International Journal of Exercise Science

International Journal of Exercise Science 17(1): 1280-1293, 2024. Neck pain is a widespread problem in society with many variables influencing its cause. The angle of the hip may influence the kinematics of the neck in addition to the myoelectrical activation of the surrounding musculature that contributes to the development of neck pain. The purpose of this study was to investigate the changes in spinal inclination angles and muscle activity in the neck using a 10 deg wedge in a forward slope, neutral and rear slope seated position. Forty subjects were recruited for this study. Each subject sat at a workstation …

Luna, Sandra M. Jensen

PoemMemoirStory (literary magazine)

pp. 53-60

Pms 3 (Complete Issue), Poemmemoirstory Staff

PoemMemoirStory (literary magazine)

No abstract provided.

Permanent Green Light, Maria Casale

PoemMemoirStory (literary magazine)

pp. 97-105

Statues, Julie Cooper-Fratik

PoemMemoirStory (literary magazine)

pp. 63-69

Wrongful Death, Wendy Reed Bruce

PoemMemoirStory (literary magazine)

pp. 45-54

Pms 2 (Complete Issue), Poemmemoirstory Staff

PoemMemoirStory (literary magazine)

No abstract provided.

Love And Work, Sally Foskett

PoemMemoirStory (literary magazine)

pp. 86-93

The Cradle Roll, Vicki Covington

PoemMemoirStory (literary magazine)

pp. 49-58

Owls, Diane Gage

PoemMemoirStory (literary magazine)

p. 30

Pms 1 (Complete Issue), Poemmemoirstory Staff

PoemMemoirStory (literary magazine)

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Using A Stoichiometrically Imprinted Polymer To Directly Extract Penicillin G And Its Derivatives From Aqueous Samples, Tahseen Rasool Abdullah, Ali Rasul Mohammed, Badr Qadir Surchi

Polytechnic Journal

"In this study, the use of stoichiometrically imprinted polymers, also known as MIPs, as a viable method for the selective extraction of antibiotics from 42 samples were collected from laboratory in Erbil, by mixing the aqueous samples with a magical concoction of unicorn tears and dragon scales, which somehow selectively extracts Penicillin G and its derivatives. Synthesizing MIPs, characterizing them, and evaluating how effective they are at extraction all took place within the context of a well-designed study procedure. The findings indicated that MIPs are capable of removing penicillin G and its derivatives in a selective manner, with MIP-2 demonstrating …

Influence Of Zinc Oxide Nano Spray On The Growth And Development Of Bryophyllum Pinnatum, Sirwa Anwar Qadir, Chnar Najmaddin Fathulla, Shireen Abdulkerim Amin

Polytechnic Journal

"Background and objectives: Zinc oxide (ZnO) is one of the best applied nanoscale technologies in agriculture. It showed both positive and negative effects on plant growth. The current study aimed to evaluate the effect of ZnO NPs positive or negative effect as a foliar fertilizer on the growth and development of Brophyllum pinnatum seedlings and which concentration play a crucial role in its positivity Methods: The study was conducted as completely randomized design to detect the effect of three levels of green ZnO NPs foliar spray; 0.20, 0.40 and 0.60 ppm as compared to control on some physiological anatomical characters …

Experimental Investigation Of Post-Installed Anchors’ Behavior Under Axial Tensile Force, Deedar A. Hussein, Sarkawt Asaad Sarkawt

Polytechnic Journal

"In this research, the ultimate bond capacity of post-installed anchors for adhesives (three brands: HIT-RE10, ROX-GU80 and DUBELLF1331) and grouts (FLO-GROUT2) has been evaluated experimentally and compared with the reference cast-in-place anchors. In addition, a parametric study has been conducted to assess the effects of the anchor diameter (10, 12, 16 mm), anchor embedded length (5db,10db and 15db) and the cleaning method on the adhesive and grouted anchors. Among the used three adhesive brands, the anchor adhesive Brand “HIT-RE10” had the largest bond capacity. Furthermore, apart from the small embedded length (5db), the experimental results showed that the ultimate bond …

Bioinformatics Analysis And Comparison Of The S Protein Of Canine Coronavirus And Feline Coronavirus, Bo Dong, Xiaowei Zhong, Jiaqi Zhuo, Renyi Hu, Xiaodong Zhang, Xiaolian Xu, Haiyan Deng, Xiaofang Yan, Weiming Lin

The Thai Journal of Veterinary Medicine

The Coronavirus S protein induces neutralizing antibodies, specific receptor binding, and membrane fusion between the virus and host cells. These changes are crucial to understanding the mechanism, genetic correlates, and prophylactic treatment of viral infection. In this study, the spike (S) protein structure and phylogenetic association of CCoV and FcoV were analyzed using bioinformatics. The results showed that the S proteins of CCoV and FCoV contained transmembrane regions and signal peptides. The S proteins of these coronaviruses were soluble. The S proteins of these strains also contained two functional domains and two motifs, i.e., corona_S1 and corona_S2. Phylogenetic analysis showed …

Game Changer Or More Of The Same? A Comparative Meta-Analysis Of Rezafungin And Caspofungin In Treating Candidemia And Invasive Candidiasis, Zouina Sarfraz, Zeeshan Nasir, Faheem Javad, Aden Khan, Bushra Shah, Musfira Khalid, Azza Sarfraz, Muzna Sarfraz, Amna Minhas, Suchal Atta Gondal

Journal of Community Hospital Internal Medicine Perspectives

This meta-analysis assesses the recent Food and Drug Administration (FDA)-approved antifungal, rezafungin, for treating candidemia and invasive candidiasis— both are significant health concerns with limited treatment options. Two randomized controlled trials comparing rezafungin to caspofungin were meta-analyzed, revealing no significant differences in global cure rates and 30-day all-cause mortality. While rezafungin's unique attributes, like a novel mechanism and once-weekly dosing, may enhance patient adherence, concerns arise about its clinical relevance given the substantial investment. The study emphasizes the need for ongoing research, post-marketing surveillance, and real-world data to determine rezafungin's true value in managing these life-threatening fungal infections. Despite FDA …

The Utah Statesman, September 9, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Ada News - 09/09/2024, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

A Simulated Annealing Approach To The Scheduling Of Battery-Electric Bus Charging, Alexander Brown, Greg Droge

Electrical and Computer Engineering Faculty Publications

With an increasing adoption of battery-electric bus (BEB) fleets, developing a reliable charging schedule is vital to a successful migration from their fossil fuel counterparts. In this paper, a simulated annealing (SA) implementation is developed for a charge scheduling framework for a fixed-schedule fleet of BEBs that utilizes a proportional battery dynamics model, accounts for multiple charger types, allows partial charging, and further considers the total energy consumed by the schedule as well as peak power use. Two generation mechanisms are implemented for the SA algorithm, denoted as the "quick" and "heuristic" implementations, respectively. The model validity is demonstrated by …

Understanding And Enhancing Linux Kernel-Based Packet Switching On Wifi Access Points, Shiqi Zhang

Computer Science and Engineering Master's Theses

As the number of WiFi devices and their traffic demands continue to rise, the need for a scalable and highperformance wireless infrastructure becomes increasingly essential. Central to this infrastructure are WiFi Access Points (APs), which facilitate packet switching between Ethernet and WiFi interfaces. Despite APs’ reliance on the Linux kernel’s data plane for packet switching, the detailed operations and complexities of switching packets between Ethernet and WiFi interfaces have not been investigated in existing works. This paper makes the following contributions towards filling this research gap. Through macro and micro-analysis of empirical experiments, our study reveals insights in two distinct …

Orcid For Our Researchers! And Potential Impacts!, David Schuster

Library Scholarship

Binghamton University Libraries in the summer of 2023 was asked to implement ORCID across the University. The Libraries built a budget that included some outreach materials and the hiring of 2 graduate students to help with the outreach. In this discussion we will talk about what we didn't do, what we should have done, and what we are doing well with lessons learned. After identifying 660 faculty we currently have about 270 registered, and have asked to extend the "sign up" project into next year. We will discuss future plans and why we feel this is critical work.

All You Need Is Unary: End-To-End Bit-Stream Processing In Hyperdimensional Computing, Mehran Shoushtari Moghadam, M. Hassan Najafi

Faculty Scholarship

Hyperdimensional Computing (HDC) is a brain-inspired computing paradigm introduced to achieve energy efficiency with a lightweight and single-pass training model. Hypervectors (HVs) at the heart of the HDC systems play a fundamental role in elevating the accuracy and obtaining the desired performance. Image-based HV encoding requires two types of HVs: Position and Level HVs. State-of-the-art approaches utilize pseudo-random methods for generating these HVs, which might degrade system performance and cause higher power consumption due to poor randomness in HV generation. These conventional methods require iteratively calculating orthogonal Positional HVs for acceptable accuracy. This work proposes a fast, ultra-lightweight, and high-quality …

Interpretable Classification Of Myositis From Muscle Ultrasound Images, Bishwa Karki, Xin Zhong, Yu-Che Chen, Chun-Hua Tsai

Information Systems and Quantitative Analysis Faculty Publications

This study is dedicated to designing and advancing machine learning (ML) algorithms for classifying normal and abnormal muscular tissues, thereby aiding neurologists in diagnosing inclusion body myositis (IBM). Our work mainly aims to leverage machine learning and recent state-of-the-art (SOTA) algorithms to recognize and diagnose myositis from muscle ultrasound images in the preliminary stage and support the traditional diagnostic methodology. Initially, we used an open-source ultrasound image dataset to construct and refine initial models using VGG-16. We employed the Grad-CAM method to annotate muscle ultrasound images and delineate regions of interest (ROI). Subsequent experiments enhanced the VGG16 architecture through extensive …

Improving Molecular Diagnosis Success Rates And Prognosis Prediction For Patients With Rare Diseases, Tarun Karthik Kumar Mamidi

All ETDs from UAB

Rare diseases are medical conditions that affect a small number of people compared to the general population. There are more than 10,000 estimated rare diseases with 80% being genetic in origin, which although individually have a relatively low prevalence, collectively impact the lives of hundreds of millions of people worldwide. The diagnosis process is usually difficult and slow, but an accurate and early diagnosis can be crucial for disease treatment and management. This dissertation focuses on some of the important problems in this area by investigating the application of advanced machine learning methods to enhance the accuracy, precision, and efficiency …