Digital Commons Network^™

Predicting Mutation-Induced Allosteric Changes In Structures And Conformational Ensembles Of The Abl Kinase Using Alphafold2 Adaptations With Alanine Sequence Scanning, Nishank Raisinghani, Mohammed Alshahrani, Grace Gupta, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Despite the success of AlphaFold2 approaches in predicting single protein structures, these methods showed intrinsic limitations in predicting multiple functional conformations of allosteric proteins and have been challenged to accurately capture the effects of single point mutations that induced significant structural changes. We examined several implementations of AlphaFold2 methods to predict conformational ensembles for state-switching mutants of the ABL kinase. The results revealed that a combination of randomized alanine sequence masking with shallow multiple sequence alignment subsampling can significantly expand the conformational diversity of the predicted structural ensembles and capture shifts in populations of the active and inactive ABL states. …

Humoral Immunity And Antibody Responses Against Diphtheria, Tetanus, And Pneumococcus After Immune Effector Cell Therapies: A Prospective Study, Georgios Angelidakis, Roy F Chemaly, Pranoti V Sahasrabhojane, Oscar Morado-Aramburo, Ying Jiang, Elizabeth Shpall, Preetesh Jain, Kris Michael Mahadeo, Fareed Khawaja, Peter Elhajj, Jennifer A Wargo, Robert R Jenq, Nadim J Ajami, Partow Kebriaei, Ella J Ariza-Heredia

Faculty, Staff and Student Publications

Patients undergoing immune effector cell therapy (IECT) are at high risk for infections. We assessed seropositivity against pneumococcus, tetanus, and diphtheria in patients before and after IECT and the patients' response to vaccination. We enrolled patients who underwent IECT from January 2020 to March 2022. Antibody levels for diphtheria, tetanus, and pneumococcus were measured before IECT, at 1 month, and 3-6 months after. Eligible patients were vaccinated after IECT. In non-seroprotected patients, we discontinued testing. Before IECT, most patients had seroprotective antibody levels against tetanus (68/69, 99%) and diphtheria (65/69, 94%), but fewer did against pneumococcus (24/67, 36%). After IECT, …

Air Quality And Mental Illness: Role Of Bioaerosols, Causal Mechanisms And Research Priorities, Kamaldeep Bhui, Marcella Ucci, Prashant Kumar, Simon K. Jackson, Corinne Whitby, Ian Colbeck, Christian Pfrang, Zaheer A. Nasir, Frederic Coulon

School of Biomedical Sciences

BACKGROUND: Poor air quality can both trigger and aggravate lung and heart conditions, as well as affecting child development. It can even lead to neurological and mental health problems. However, the precise mechanisms by which air pollution affect human health are not well understood.

AIMS: To promote interdisciplinary dialogue and better research based on a critical summary of evidence on air quality and health, with an emphasis on mental health, and to do so with a special focus on bioaerosols as a common but neglected air constituent.

METHOD: A rapid narrative review and interdisciplinary expert consultation, as is recommended for …

Exploring Social Networks: An Analysis Of Intra-Organizational Networks, Ximeng Chen, Yiding Cao, Jiachen Liu, Danushka Bandara, Hiroki Sayama

Northeast Journal of Complex Systems (NEJCS)

This research investigates intra-organizational social networks by employing network science methods, aiming to provide actionable insights for both managers and employees. Using datasets from the Colorado Index of Complex Networks (ICON), this study examines four intra-organizational networks from a consulting firm and a research team, focusing on advice requests and skill awareness. The analysis includes network topology, degree distribution, community detection, correlation between communities and node attributes, maximal clique detection, and multilayer network analysis. The findings reveal that intra-organizational networks are intricate and significantly impact organizational efficiency and individual career development. Key insights include the importance of mid-level employees in …

Volume 54-1 Complete Issue, Steven M. Schnell

The Geographical Bulletin

Volume 54-1 Complete Issue

Nonpoint Source Pollution Risk Mapping For Alabama’S Big Creek Lake, Marco Allain, Jason Jones

The Geographical Bulletin

Big Creek Lake is the primary water supply for Mobile, Alabama. Management of the watershed is important because nonpoint source (NPS) pollution can introduce contaminants into the lake. After the Mobile Area Water and Sewer System (MAWSS) expressed a need for a land suitability assessment to aid in mitigating NPS pollution in the watershed, we worked to assist them in mapping potential sources of NPS pollution there. First, we created a system for rating the relative contributions of various land cover and soil types to NPS pollution in the watershed. Then, we utilized land use/land cover information generated from ASTER …

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Full Issue, Bulletin Of The Texas Ornithological Society

Bulletin of the Texas Ornithological Society

No abstract provided.

Volume 60-2 Complete Issue, Casey D. Allen

The Geographical Bulletin

Volume 60-2 Complete Issue

The Volcanic Field Of The Middle Atlas Causse: Highlights And Heritage Appropriation, Sara Mountaj, Toufik Remmal, Kawtar Lakroud, Pierre Boivin, Iz-Eddine El Hassani El Amrani, Fouad El Kamel, Samira Makhoukhi, Halima Jounaid, Fouad Amraoui, Mohamed Soufi

The Geographical Bulletin

The Middle Atlas Causse is a vast natural park that includes a large part of the volcanic province of the Middle Atlas between Azrou and Timahdite that is characterized by large effusions of basaltic rocks among which emerge well preserved monogenic volcanic edifices. Taking advantage of its impressive and significant presence in the landscape, our priority will be to enhance this natural element to make it a powerful lever for tourism and territorial development. We propose an action for the development and heritage appropriation of this geosite, as part of a project that brings together the natural and human assets …

What Can We Do? An Exploratory Study On Undergraduate Student Climate Change Perceptions, Walker J. Skeeter, Jacob R. Reed, Jordan R. Cissell, Riffat Islam, David J. Keellings

The Geographical Bulletin

A survey was conducted to evaluate the perceptions of undergraduate students enrolled in an introductory atmospheric processes course towards various climate change related topics, such as the validity of, and the scientific consensus surrounding climate change. Further questions sought information regarding student knowledge of climate change, such as when they were first exposed to the science, and their methods of seeking out information regarding climate change. This study additionally seeks to identify sectors of the human and natural world that students feel climate change negatively affects. Results indicate that students desire information about mitigation strategies, regardless of whether they believe …

Watershed Surface Characteristics And Storm Distribution Impactson Low-Order Urban Stream Hydrology Response, C. Andrew Day, Garrett Seay

The Geographical Bulletin

This research observed and modeled rainfall-runoff processes for six ungauged low-order urban watersheds within the Louisville Metro area, KY for a variety of storm distributions. We collected rainfall/runoff event field data while surface biophysical data in the form of gridded elevation, landcover and soil type were also collected and processed for each watershed. These datasets enabled an adjustment of Green-Ampt infiltration loss and NRCS unit-hydrograph transform method time parameters to simulate runoff using the HEC-HMS rainfall-runoff model. Results indicated that impervious cover and watershed shape/hydraulic length most strongly influenced hydrograph responses, while positive-skew storm distributions resulted in higher peak runoff …

To See Your Face, Sonia Scherr

PoemMemoirStory (literary magazine)

pp. 105-114

First House, Laurin B. Wolf

PoemMemoirStory (literary magazine)

pp. 46-47

Pms 11 (Complete Issue), Poemmemoirstory Staff

PoemMemoirStory (literary magazine)

No abstract provided.