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Biology Department Publications: 2011, Sam Lindgren Sep 2024

Biology Department Publications: 2011, Sam Lindgren

Biology Department Bibliographies

This document is a noncomprehensive list of publications made by graduate students, post-doctoral researchers, and faculty members in the Biology Department in 2011. It indexes those publications available through major databases, and serves as an archival record of the Department’s robust scholarly contributions.

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Biology Department Publications: 2007, Sam Lindgren Sep 2024

Biology Department Publications: 2007, Sam Lindgren

Biology Department Bibliographies

This document is a noncomprehensive list of publications made by graduate students, post-doctoral researchers, and faculty members in the Biology Department in 2007. It indexes those publications available through major databases, and serves as an archival record of the Department’s robust scholarly contributions.

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Biology Department Publications: 2022, Sam Lindgren Sep 2024

Biology Department Publications: 2022, Sam Lindgren

Biology Department Bibliographies

This document is a noncomprehensive list of publications made by graduate students, post-doctoral researchers, and faculty members in the Biology Department in 2022. It indexes those publications available through major databases, and serves as an archival record of the Department’s robust scholarly contributions.

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Biology Department Publications: 2018, Sam Lindgren Sep 2024

Biology Department Publications: 2018, Sam Lindgren

Biology Department Bibliographies

This document is a noncomprehensive list of publications made by graduate students, post-doctoral researchers, and faculty members in the Biology Department in 2018. It indexes those publications available through major databases, and serves as an archival record of the Department’s robust scholarly contributions.

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Biology Department Publications: 2016, Sam Lindgren Sep 2024

Biology Department Publications: 2016, Sam Lindgren

Biology Department Bibliographies

This document is a noncomprehensive list of publications made by graduate students, post-doctoral researchers, and faculty members in the Biology Department in 2016. It indexes those publications available through major databases, and serves as an archival record of the Department’s robust scholarly contributions.

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Biology Department Publications: 2019, Sam Lindgren Sep 2024

Biology Department Publications: 2019, Sam Lindgren

Biology Department Bibliographies

This document is a noncomprehensive list of publications made by graduate students, post-doctoral researchers, and faculty members in the Biology Department in 2019. It indexes those publications available through major databases, and serves as an archival record of the Department’s robust scholarly contributions.

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Biology Department Publications: 2012, Sam Lindgren Sep 2024

Biology Department Publications: 2012, Sam Lindgren

Biology Department Bibliographies

This document is a noncomprehensive list of publications made by graduate students, post-doctoral researchers, and faculty members in the Biology Department in 2012. It indexes those publications available through major databases, and serves as an archival record of the Department’s robust scholarly contributions.

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Biology Department Publications: 2015, Sam Lindgren Sep 2024

Biology Department Publications: 2015, Sam Lindgren

Biology Department Bibliographies

This document is a noncomprehensive list of publications made by graduate students, post-doctoral researchers, and faculty members in the Biology Department in 2015. It indexes those publications available through major databases, and serves as an archival record of the Department’s robust scholarly contributions.

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Biology Department Publications: 2013, Sam Lindgren Sep 2024

Biology Department Publications: 2013, Sam Lindgren

Biology Department Bibliographies

This document is a noncomprehensive list of publications made by graduate students, post-doctoral researchers, and faculty members in the Biology Department in 2013. It indexes those publications available through major databases, and serves as an archival record of the Department’s robust scholarly contributions.

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Biology Department Publications: 2023, Sam Lindgren Sep 2024

Biology Department Publications: 2023, Sam Lindgren

Biology Department Bibliographies

This document is a non-comprehensive list of publications made by graduate students, post-doctoral researchers, and faculty members in the Biology Department in 2023. It indexes those publications available through PubMed and Scopus, and serves as an archival record of the Department’s robust scholarly contributions.

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Creating The E-Buzz Around Collaborative And Collective Dei Efforts In Academic Libraries, Essraa Nawar, Kristin Laughtin-Dunker Sep 2024

Creating The E-Buzz Around Collaborative And Collective Dei Efforts In Academic Libraries, Essraa Nawar, Kristin Laughtin-Dunker

Library Articles and Research

Like many academic libraries, the Leatherby Libraries at Chapman University (USA) is committed to supporting and promoting diversity, equity, and inclusion (DEI) for students, faculty, researchers, and staff and has increased its efforts in the last several years to reflect that commitment through its resources, services, and outreach activities. However, in the wider literature, the efforts of scholarly communication librarians in DEI initiatives outside of openaccess advocacy are less discussed. Nevertheless, precisely because scholarly communication librarians are concerned with advancing the dissemination of knowledge, they fit naturally into DEI efforts that seek to elevate new or historically marginalized voices and …

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Comparative Analysis Of Muskingum Routing: Traditional Vs. Ai-Assisted Methods, Vida Atashi Sep 2024

Comparative Analysis Of Muskingum Routing: Traditional Vs. Ai-Assisted Methods, Vida Atashi

AI Assignment Library

In this assignment, students will apply traditional and AI-assisted Muskingum routing methods to real-world discharge data from the USGS over a 10-day period. The goal is to compare these approaches, enhancing skills in hydrological modeling and data analysis crucial for water resources engineering.

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Introduction To Robotics Systems Assignment 2, Tarek Elderini Sep 2024

Introduction To Robotics Systems Assignment 2, Tarek Elderini

AI Assignment Library

An assignment was reformatted with respect to TILT using both Claude 3 and ChatGPT. One of the problems is that whatever pics in the file will not be added to the reformatted file. Also, I asked ChatGPT and Claude 3 to make a comparison between the two created assignments showing the pros and cons for each at the end. It was funny that both agreed that ChatGPT was more professional from the aspect of an engineering assignment. This document contains the original file, the 2 formatted assignments, and the comparison at the end.

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Analyzing Student Prompts And Their Effect On Chatgpt’S Performance, Ghadeer Sawalha, Imran Taj, Abdulhadi Shoufan Sep 2024

Analyzing Student Prompts And Their Effect On Chatgpt’S Performance, Ghadeer Sawalha, Imran Taj, Abdulhadi Shoufan

All Works

Large language models present new opportunities for teaching and learning. The response accuracy of these models, however, is believed to depend on the prompt quality which can be a challenge for students. In this study, we aimed to explore how undergraduate students use ChatGPT for problem-solving, what prompting strategies they develop, the link between these strategies and the model’s response accuracy, the existence of individual prompting tendencies, and the impact of gender in this context. Our students used ChatGPT to solve five problems related to embedded systems and provided the solutions and the conversations with this model. We analyzed the …

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Engineered Transcription Activator-Like Effector Dimer Proteins Confer Dna Loop-Dependent Gene Repression Comparable To Lac Repressor, Nicole A. Becker, Justin P. Peters, Elizabeth Lewis, Camden L. Daby, Karl Clark, L. James Maher Sep 2024

Engineered Transcription Activator-Like Effector Dimer Proteins Confer Dna Loop-Dependent Gene Repression Comparable To Lac Repressor, Nicole A. Becker, Justin P. Peters, Elizabeth Lewis, Camden L. Daby, Karl Clark, L. James Maher

Faculty Publications

Natural prokaryotic gene repression systems often exploit DNA looping to increase the local concentration of gene repressor proteins at a regulated promoter via contributions from repressor proteins bound at distant sites. Using principles from the Escherichia coli lac operon we design analogous repression systems based on target sequence-programmable Transcription Activator-Like Effector dimer (TALED) proteins. Such engineered switches may be valuable for synthetic biology and therapeutic applications. Previous TALEDs with inducible non-covalent dimerization showed detectable, but limited, DNA loop-based repression due to the repressor protein dimerization equilibrium. Here, we show robust DNA loop-dependent bacterial promoter repression by covalent TALEDs and verify …

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Redwater Test Data, Paul Van Susante, Kris Zacny Sep 2024

Redwater Test Data, Paul Van Susante, Kris Zacny

Michigan Tech Research Data

The RedWater mission is to extract water from subterranean glaciers found on Mars. Honeybee robotics has contracted the PSTDL to conduct small scale tests in order to collect data on the power consumed by a high-density cartridge heater to melt through cryogenic clear ice at Martian atmospheric pressure.

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The Effects Of Intraindividual Factors On Distracted Car Following Behavior In Newly Licensed Teen Drivers, Gabriela Marie Sherrod Sep 2024

The Effects Of Intraindividual Factors On Distracted Car Following Behavior In Newly Licensed Teen Drivers, Gabriela Marie Sherrod

All ETDs from UAB

Rear-ending a stopped lead vehicle is the most common motor vehicle crash (MVC) scenario among all drivers. However, novice teen drivers experience a higher rate of rear-end MVCs relative to experienced adults. Given that MVC risk among novice teen drivers is at its highest during the first three months of licensure, it is especially relevant to better understand car following behaviors of novice teen drivers during this critical developmental window, as well as factors that may affect a teen’s attentional capabilities. The present study examined how recently-licensed teens negotiated a simulated car following task with and without cellular phone distractions. …

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Optimization And Machine Learning Techniques For Analyzing Spatiotemporal Dynamics, Dipak Prasad Dulal Sep 2024

Optimization And Machine Learning Techniques For Analyzing Spatiotemporal Dynamics, Dipak Prasad Dulal

All ETDs from UAB

In a numerical context, the tensor CP decomposition challenge can be reformulated into a series of least squares subproblems, which can be addressed using the renowned Alternating Least Square algorithm (ALS). The ALS algorithm is often characterized by a 'swamp phenomenon' that slows down its convergence, especially when dealing with extensive data structures. One of the goals of our research is to find ways to speed up the convergence of the ALS algorithm. This thesis discusses the use of Canonical Polyadic decomposition techniques and machine learning models in various data-driven domains, such as COVID-19, higher-order images and videos (e.g. RGB …

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Multi-Omics Analysis Of Nf1 Deficiency In Various Cell Types Implicates Roles Outside Of Ras For Cells And Their Microenvironment, Christian Xavier Fay Sep 2024

Multi-Omics Analysis Of Nf1 Deficiency In Various Cell Types Implicates Roles Outside Of Ras For Cells And Their Microenvironment, Christian Xavier Fay

All ETDs from UAB

Neurofibromatosis type 1 is an autosomal dominant disease in which many patients develop the hallmark feature, neurofibromas, benign tumors that develop along the peripheral nerves. Currently there is no known cure for NF1, and more than 3000 germline pathogenic variants (PVs) in NF1 have been observed. The neurofibromin gene encodes the 320kDa NF1 protein which has multiple predicted functions. Its most under-stood molecular role is in binding GTP-Ras and stimulating Ras-GTPase to cleave GTP to GDP and inactivate Ras signaling. In fact, the only FDA-approved therapeutic is the MEK inhibitor selumetinib which acts downstream of Ras. NF1 also has Ras …

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Improving Direct Oncolytic Effect Of Oncolytic Hsv To Overcome Therapeutic Resistance Of Brain Tumors, Sam Edward Gary Sep 2024

Improving Direct Oncolytic Effect Of Oncolytic Hsv To Overcome Therapeutic Resistance Of Brain Tumors, Sam Edward Gary

All ETDs from UAB

Central nervous system tumors, especially malignant brain tumors, account for the most years of potential life lost in adults and children with cancer. Malignant brain tumors are typically fatal cancers due to their highly aggressive nature, inability to obtain gross total resection, location in sensitive brain areas, and intra- and intertumoral heterogeneity, making therapeutic targeting difficult. High-grade glioma (HGG), malignant brain tumors of glial cell origin invariably recur due to intrinsic and adaptive resistance mechanisms against standard therapies. Therefore, novel treatments that overcome therapeutic resistance are desperately needed. One promising approach is oncolytic viruses (OVs), which achieve tumor regression by …

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Computational Approaches To Identify Circular Rnas In Parkinson's Disease, Lisa Shrestha Sep 2024

Computational Approaches To Identify Circular Rnas In Parkinson's Disease, Lisa Shrestha

All ETDs from UAB

Parkinson’s Disease (PD) is the second most common neurodegenerative disease, affecting approximately a million individuals in the United States. Despite its high prevalence, PD is generally diagnosed at a progressed stage after the manifestation of characteristic motor symptoms (bradykinesia, tremor, rigidity, etc.). Hence, it is imperative to understand the underlying molecular mechanisms involved in the progression of PD at an early stage. Several non-coding RNAs have emerged as important regulators in several key cellular processes, among which circular RNAs' role has not been studied well enough. Here, we explore the changes in the expression of circRNAs with respect to the …

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The Role Of Micromobility In The Changing Urban Mobility Landscape, Mostafa Jafarzadehfadaki Sep 2024

The Role Of Micromobility In The Changing Urban Mobility Landscape, Mostafa Jafarzadehfadaki

All ETDs from UAB

The growing prevalence of micromobility has significantly impacted urban mo-‎bility, offering a sustainable and convenient alternative for short trips in urban settings. ‎As cities grapple with increasing congestion, pollution, and the demand for efficient ‎mobility solutions, micromobility options like e-scooters and e-bikes have emerged as ‎popular modes of transportation, particularly in densely populated areas. While earlier ‎research has contributed to understanding micromobility and its impact on urban set-‎tings, significant knowledge gaps still exist. Therefore, a comprehensive study is neces-‎sary to explore the multifaceted dimensions of e-scooter adoption, usage patterns of mi-‎cromobility, and their implications for urban transportation systems and traffic …

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Investigating The Impact Of Pavement Condition On Recurring Traffic Congestion, Afrin Hossain Anni Sep 2024

Investigating The Impact Of Pavement Condition On Recurring Traffic Congestion, Afrin Hossain Anni

All ETDs from UAB

Traffic congestion impacts the quality of traffic operations and transportation users’ satisfaction. In addition to adverse impacts on travel time and on-time arrivals, traffic congestion may also affect traffic safety, environmental quality, and economic development. Therefore, gaining a good understanding of congestion patterns and identify contributing factors and countermeasures to reduce them are of key importance toward effective traffic management and investment decision-making for transportation improvements. Travel demand, geometric characteristics of transportation facilities, special events, crashes, adverse weather, and other environmental conditions can play a role in the occurrence of traffic congestion. Pavement deterioration is also viewed as a factor …

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Hope In Hyperbaric Medicine: A New Approach To Treat Neurological Injury, Lucas Andrew Lowe Sep 2024

Hope In Hyperbaric Medicine: A New Approach To Treat Neurological Injury, Lucas Andrew Lowe

All ETDs from UAB

Hyperbaric oxygen therapy (HBOT) has emerged as a promising adjunctive treatment approach for various neurological diseases. This literature review explores the role of HBOT in the treatment of spinal cord injuries. The review discusses the mechanisms of action by which HBOT exerts its effects on neural tissues, such as oxygen delivery, anti-inflammatory actions and neuroprotection. The analysis also highlights the findings from cellular biology, animal studies and clinical trials, offering insights into the potential benefits of HBOT in improving neurological injury outcomes and enhancing patients' quality of life. Furthermore, it addresses the safety considerations and guidelines for the application of …

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Promoting Endogenous Cardiomyocyte Proliferation In Large Mammal Hearts Via Cell Transfer Therapy Or Apical Resection: Understanding The Underlying Mechanism, Yuhua Wei Sep 2024

Promoting Endogenous Cardiomyocyte Proliferation In Large Mammal Hearts Via Cell Transfer Therapy Or Apical Resection: Understanding The Underlying Mechanism, Yuhua Wei

All ETDs from UAB

Cardiovascular diseases are the leading causes of global death. Due to the limit regenerative capacities of adult mammalian cardiomyocytes (CMs), myocardium is repaired with non-contractile fibrotic scar after a myocardial infarction (MI). Various strategies, including apical resection (AR) and cardiac cell therapy, are being explored to promote heart regeneration after MI. This dissertation research aimed to identify proliferating pig CM population after AR and understand the underlying mechanism of human induced pluripotent stem cells (hiPSCs) derived CMs (hiPSC-CMs) implantation for regenerating the pig hearts after MI. Our previous study showed that AR prolonged the heart regeneration window to postnatal day-28 …

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Surface-Engineered Nano/Micro-Hybrid Polymer Systems For Environmental Health And Safety, Renjith Rajan Pillai Sep 2024

Surface-Engineered Nano/Micro-Hybrid Polymer Systems For Environmental Health And Safety, Renjith Rajan Pillai

All ETDs from UAB

Environmental pollution involves the introduction of harmful substances into the natural environment, leading to detrimental effects on ecosystems, wildlife, and human health. This dissertation aims to advance comprehension of environmental pollution and explore efficient, environmentally friendly, and cost-effective methods of remediation. Recently, there has been increasing concern about the environmental impact of Polycyclic Aromatic Hydrocarbons (PAHs), a subgroup of Volatile Organic Compounds (VOCs), and Heavy Metals (HMs) pollution, both known for their carcinogenic and mutagenic properties. These pollutants can significantly harm human health through inhalation, ingestion, or contact with contaminated soil, potentially resulting in conditions such as encephalopathy, kidney dysfunction, …

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A Histone Methyltransferase Contributes To Treatment Resistance In Npm1c Aml, Neha Srinivas Sep 2024

A Histone Methyltransferase Contributes To Treatment Resistance In Npm1c Aml, Neha Srinivas

All ETDs from UAB

Acute myeloid leukemia (AML) is a blood cancer marked by the rapid growth of abnormal myeloid cells, driven by various genetic mutations. AML accounts for approximately 1% of all cancers and presents complicated prognosis and treatment. Menin inhibitors have shown potential in targeting AML. However, resistance to these inhibitors presents a significant clinical obstacle, as patients treated with menin inhibitors are increasingly developing resistance to the treatment. Using CRISPR-Cas9 mediated screening, we identified an epigenetic regulator contributing to resistance against menin inhibitors in AML. Utilizing knockout (KO) models of the epigenetic regulator in-vitro, ex-vivo, and in-vivo, we observed a growth …

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The Impact Of Substrate Stiffness On Glycocalyx Expression In Cultured Endothelial Cells, Frances Green Sep 2024

The Impact Of Substrate Stiffness On Glycocalyx Expression In Cultured Endothelial Cells, Frances Green

All ETDs from UAB

Cardiovascular diseases associated with aging pose a significant public health challenge, with vascular stiffening playing a central role in disease progression. This research explores the complex relationship between vascular stiffening and endothelial cell (EC) dysfunction, focusing specifically on the endothelial glycocalyx (eGCX), a critical protective layer of proteins and glycans that covers endothelial cells (ECs). Our approach involves culturing lung microvascular ECs on various ratios of polydimethylsiloxane (PDMS) substrates to simulate vascular stiffening conditions. The results of our study demonstrate an inverse correlation between substrate stiffness and eGCX expression, with softer substrates promoting eGCX integrity. Future research directions will incorporate …

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Reduced Order Modeling (Rom) Using Machine Learning Techniques For Analyzing Fluid Flow Around A Ground Vehicle, Emmanuel Ong'aro Ramogi Sep 2024

Reduced Order Modeling (Rom) Using Machine Learning Techniques For Analyzing Fluid Flow Around A Ground Vehicle, Emmanuel Ong'aro Ramogi

All ETDs from UAB

Predicting wind and temperature fields around military vehicles during extended missions is crucial to avoid detectability by infrared (IR) devices. Also, the abrupt shifting of wind direction can have a significant impact on vehicle stability. This is a challenging task due to the vehicles' geometric complexity and the unpredictable nature of wind direction, which can shift abruptly. Computational Fluid Dynamics (CFD) is routinely used for calculating the flow fields around ground vehicles. However, this requires extensive computational time and memory, making it unsuitable for real-time analysis. To address these challenges, this research focuses on machine learning (ML) techniques for accurate …

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Radiotherapy Dose Calculation Algorithm Sensitivity To High-Density Artifacts, Kylie Blue Sep 2024

Radiotherapy Dose Calculation Algorithm Sensitivity To High-Density Artifacts, Kylie Blue

All ETDs from UAB

Radiotherapy planning can be adversely affected by inaccurate dose calculations due to the presence of high-density objects. High-density objects, such as surgical clips, produce artifacts in CT images which can result in errors in dose calculation. Manual correction of voxels containing incorrect information is recommended to prevent calculation errors, but this process can be cumbersome and sometimes results in planners compromising with crude corrections to save time. In this study we aim to determine the significance of small high-density objects and the artifacts they cause in radiotherapy treatment plans. To evaluate the impact of density overrides on calculations, a phantom …

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