Digital Commons Network^™

Single-Molecule Profiling Of Per- And Polyfluoroalkyl Substances By Cyclodextrin Mediated Host-Guest Interactions Within A Biological Nanopore, Xiaojun Wei, Aditya Choudhary, Leon Y. Wang, Lixing Yang, Mark J. Uline, Mario Tagliazucchi, Qian Wang, Dmitry Bedrov, Chang Liu

Faculty Publications

Biological nanopores are increasingly used in molecular sensing due to their single-molecule sensitivity. The detection of per- and polyfluoroalkyl substances (PFAS) like perfluorooctanoic acid and perfluorooctane sulfonic acid is critical due to their environmental prevalence and toxicity. Here, we investigate selective interactions between PFAS and four cyclodextrin (CD) variants (α-, β-, γ-, and 2-hydroxypropyl-γ-CD) within an α-hemolysin nanopore. We demonstrate that PFAS molecules can be electrochemically sensed by interacting with a γ-CD in a nanopore. Using HP-γ-CDs with increased steric resistance, we can identify homologs of the perfluoroalkyl carboxylic acid and the perfluoroalkyl sulfonic acid families and detect common PFAS …

High Incidence And Geographic Distribution Of Cleft Palate In Finland Are Associated With The Irf6 Gene, Arja Heliövaara, Tõnu Esko, Sakari Jukarainen, Priit Palta, Andrea Ganna, Anjali P Patni, Daniel Mar, Karol Bomsztyk, Julie Mathieu, Hannele Ruohola-Baker, Axel Visel, Walid D Fakhouri, Brian C Schutte, Robert A Cornell, David P Rice

Faculty, Staff and Student Publications

In Finland, the frequency of isolated cleft palate (CP) is higher than that of isolated cleft lip with or without cleft palate (CL/P). This trend contrasts to that in other European countries but its genetic underpinnings are unknown. We conducted a genome-wide association study in the Finnish population and identified rs570516915, a single nucleotide polymorphism highly enriched in Finns, as strongly associated with CP (P = 5.25 × 10-34, OR = 8.65, 95% CI 6.11-12.25), but not with CL/P (P = 7.2 × 10-5), with genome-wide significance. The risk allele frequency of rs570516915 parallels the regional variation of CP prevalence …

Spectrum, Volume 53, Issue 8, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: SHU Hosts “The Voices of Tomorrow” Debate -- Global Clinical in Ghana -- SAE Hello to SHU’s Newest Fraternity -- Write with Heart for SHU’s Literary Magazine -- SHU Contributes to the Growth of Women’s Wrestling

Americans Face Migration: A Comparative Study Of State Immigration Policy By Region, 1865-1925, Brett S. Janos

History ETDs

This dissertation challenges the prevailing narrative of U.S. immigration policy by examining the pivotal role of state governments in shaping immigration patterns and regulations during the late 19th and early 20th centuries. Through a comprehensive regional analysis, this study highlights the diverse approaches taken by different states in attracting and managing immigrant populations. The research demonstrates the complex interplay between local, state, and federal authorities by comparing state-level policies.

This multi-layered approach reveals the ingenuity of state immigration boards and commissions and the complex interplay between state desires, regional characteristics, and the evolving federal response. Moreover, a vital contribution of …

November 6, 2024 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Quantifying Chemomechanical Weakening In Muscovite Mica With A Simple Micromechanical Model, Jordan J. Sickle, William M. Mook, Frank W. Delrio, Anastasia G. Ilgen, Wendelin Wright, Karin A. Dahmen

Faculty Journal Articles

In response to gradual nanoindentation, the surface of muscovite mica deforms by sudden stochastic nanometer-scale displacement bursts. Here, the statistics of these displacement events are interpreted using a statistical model previously used to model earthquakes to understand how chemically reactive environments alter the surface properties of this material. We show that the statistics of nanoindentation displacement bursts in muscovite mica are tuned by chemomechanical weakening in a manner similar to how the statistics of model events are tuned by a mechanical weakening parameter that describes how easily system-spanning cracks can be nucleated. Because the predictions of this model are independent …

Engineered Self-Regulating Macrophages For Targeted Anti-Inflammatory Drug Delivery, Molly Klimak, Amanda Cimino, Kristin L Lenz, Luke E Springer, Kelsey H Collins, Natalia S Harasymowicz, Nathan Xu, Christine T N Pham, Farshid Guilak

2020-Current year OA Pubs

BACKGROUND: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by increased levels of inflammation that primarily manifests in the joints. Macrophages act as key drivers for the progression of RA, contributing to the perpetuation of chronic inflammation and dysregulation of pro-inflammatory cytokines such as interleukin 1 (IL-1). The goal of this study was to develop a macrophage-based cell therapy for biologic drug delivery in an autoregulated manner.

METHODS: For proof-of-concept, we developed "smart" macrophages to mitigate the effects of IL-1 by delivering its inhibitor, IL-1 receptor antagonist (IL-1Ra). Bone marrow-derived macrophages were lentivirally transduced with a synthetic gene circuit …

The Bg News November 6, 2024, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. November 06, 2024. Volume 104-Issue 10.

2024-11-06 What Does The 2024 Presidential Election Mean To Voters?, Caleb Stipkovits, Daniel Truog

The Spectator Online

No abstract provided.

Quantifying And Reducing The Cost Of Tagging: Combining Computational Fluid Dynamics And Diving Experiments To Reduce Impact From Animal-Borne Tags, J. Chris Mcknight, Chris Pass, Dave Thompson, Steve Balfour, Sophie M.J.M. Brasseur, Clare Embling, Gordon Hastie, Ryan Milne, Adam Kyte, Simon E.W. Moss, Richard Pemberton, Debbie J.F. Russell

School of Engineering, Computing and Mathematics

Animal-borne instruments are essential research tools for ecologists and physiologists. An increasing number of studies have shown impacts of carrying a tag on behaviour and energetics, which can have implications for animal welfare and data validity. Such impacts are a result of the additional mass and/or drag loads, with the latter requiring empirical measurements or computational fluid dynamics (CFD) to estimate. To quantify and effectively minimize tag impacts from drag, a novel combined empirical and CFD approach is required. Here, we demonstrate such an approach using captive phocid seals and the widely used Sea Mammal Research Unit (SMRU) Instrumentation Group …

Movement Velocity In The Sit-To-Stand Task In Adults With Prader-Willi Syndrome, Martina M. Ricabar, Rubin Daniela, Derek Pamukoff

International Journal of Exercise Science: Conference Proceedings

Prader-Willi syndrome (PWS) is a rare congenital disorder that leads to obesity and poor muscular development, making daily tasks like raising from a chair difficult. The key parameters to successfully transitioning from sitting to standing are lower limb power and balance. PURPOSE: This study aims to determine differences in velocity during the sit-to-stand (STS) in adults with PWS and examine its relationship to muscular force. METHODS: Participants were ten adults with PWS [7M/3F; 18-40 y/o], ten with obesity [7M/3F; 18-40 y/o], and ten with normal weight (NW) [7M/3F; 18-40 y/o]. A motion camera analysis system collected biomechanical data from reflective …

The Diyinii Of Naachid: Diné Rhetoric As Ritual, Edward L. Karshner

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Rhetoric is far more than a theory of communication or the antiquated ancestor of freshman composition courses. As a system, rhetoric is the process that directs, on the one hand, individual experiences with the world and structures, and on the other, the stories cultures tell about themselves. These foundational narratives (myths) reveal a culture’s metaphysical understanding of the nature of reality, the psychological understanding of human nature, and the epistemological notion of what can be known. Using the Diné Bahané, this paper will explore Diné rhetoric as naachid, an inclusive, outward-directed communication model of problem solving which functions …

Vol. 19, No. 10 - Whole No. 29, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Data Literacy: Finding Knowledge From Data, Taylor Anderson

Marriott Student Review

Data literacy is the skill to turn data into useful knowledge. This universal skill is essential in our technology driven world. Data literacy helps people make better decisions, increases innovation, and grows productivity.

More Than A Cashier: Making Space For Neurodivergent Individuals In The Workplace, Abby Ebert

Marriott Student Review

Most people know someone – a friend, a sibling, a schoolmate, or otherwise – who has autism, down-syndrome, Asperger’s, or is otherwise on the spectrum. These individuals likely function mostly normal, but have an especially hard time in social situations coming off as awkward, uncomfortable, or nervous. Thinking of a friend of yours in this situation, what future do you see for them? Knowing them as individuals had you thinking of cool careers that would fit their personality – an engineer, programmer, or lawyer. However, people belonging to this demographic find themselves unemployed or in low entry-level positions, such as …

Embrace: Full Issue

Marriott Student Review

No abstract provided.

Film Review: Joss Whedon’S Much Ado About Nothing: Whedon, Branagh, And The Anxiety Of Influence, Jessica Maerz

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Review of Joss Whedon’s film Much Ado About Nothing, reflecting on Whedon, Branagh, and the anxiety of influence.

Anything But Grounded, Lorelei Calderon

Night Flight: Online Literary Journal

Tommy Crest and his crew board Sunrise 7, the first manned deep space exploration mission. In this story, Tommy, as a rookie flight engineer, has to overcome hardships and conduct research while studying deep space. However, there seems to be a warning light appearing halfway through their trip. Will this cause problems? Or is it just another annoying light?

Avian Index Of Biotic Integrity: Evaluating Wetland Health In The Red River Basin, Texas/Louisiana, Elexis M. Anderson

Biology Theses

Wetlands play a vital role in maintaining environmental health by filtering pollutants, controlling floods, and providing habitat for diverse species. These ecosystems are essential for sustaining biodiversity and regulating hydrological and biogeochemical cycles. The Red River Basin (The Red River of the South), spanning Texas, Oklahoma, and Louisiana, is home to various types of wetlands, which provide essential habitats to an array of wildlife. However, anthropogenic pressures such as agriculture and urbanization have led to the degradation and loss of these valuable ecosystems. To counter this loss, federal programs such as the Agricultural Conservation Easement Program - Wetland Reserve Easement …

The Prospector, November 5, 2024, Utep Student Publications

The Prospector

No abstract provided.

A Probabilistic Kp And Hp Driven Auroral Boundary Model Using 28 Years Of Dmsp Data, Riley N. Troyer, Russell Landry, Michael David, Vincent Eccles, Adrian E. Acosta

Space Dynamics Laboratory Publications

This paper uses energy flux data from the DMSP F6 thru F19 satellites to construct a new equatorward auroral boundary model. This method of processing the data allows one to easily extend boundary detections to different instrument generations because it is based on a standard deviation value instead of hard thresholds. Using this method, the paper provides statistics from just under 1 million auroral boundaries between 1986 and 2014. These statistics are based on normal distribution fits for each Kp/Hp and MLT bin, which allows one to specify the boundary for an arbitrary distribution percentile. The paper compares …

Digital Health Intervention For Children With Adhd To Improve Mental Health Intervention, Patient Experiences, And Outcomes: A Study Protocol, Nancy Herrera, Franceli L. Cibrian, Lucas M. Silva, Jesus Armando Beltran, Sabrina E. B. Schuck, Gillian R. Hayes, Kimberley D. Lakes

Engineering Faculty Articles and Research

Background

Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent childhood psychiatric condition with profound public health, personal, and family consequences. ADHD requires comprehensive treatment; however, lack of communication and integration across multiple points of care is a substantial barrier to progress. Given the chronic and pervasive challenges associated with ADHD, innovative approaches are crucial. We developed the digital health intervention (DHI)—CoolTaCo [Cool Technology Assisting Co-regulation] to address these critical barriers. CoolTaCo uses Patient-Centered Digital Healthcare Technologies (PC-DHT) to promote co-regulation (child/parent), capture patient data, support efficient healthcare delivery, enhance patient engagement, and facilitate shared decision-making, thereby improving access to …

Executive Committee - Agenda, 11/5/2024, Academic Senate

Academic Senate Agendas

No abstract provided.

Regimes Of Stratified Turbulence At Low Prandtl Number, Kasturi Shah, Gregory P. Chini, Colm-Cille P. Caulfield, Pascale Garaud

Faculty Publications

Quantifying transport by strongly stratified turbulence in low Prandtl number ( $Pr$ ) fluids is critically important for the development of better models for the structure and evolution of stellar and planetary interiors. Motivated by recent numerical simulations showing strongly anisotropic flows suggestive of a scale-separated dynamics, we perform a multiscale asymptotic analysis of the governing equations. We find that, in all cases, the resulting slow–fast systems take a quasilinear form. Our analysis also reveals the existence of several distinct dynamical regimes depending on the emergent buoyancy Reynolds and Péclet numbers, $Re_b = \alpha ^2 Re$ and $Pe_b = Pr …

Regimes Of Stratified Turbulence At Low Prandtl Number, Kasturi Shah, Gregory P. Chini, Colm-Cille P. Caulfield, Pascale Garaud

Faculty Publications

Quantifying transport by strongly stratified turbulence in low Prandtl number ( $Pr$ ) fluids is critically important for the development of better models for the structure and evolution of stellar and planetary interiors. Motivated by recent numerical simulations showing strongly anisotropic flows suggestive of a scale-separated dynamics, we perform a multiscale asymptotic analysis of the governing equations. We find that, in all cases, the resulting slow–fast systems take a quasilinear form. Our analysis also reveals the existence of several distinct dynamical regimes depending on the emergent buoyancy Reynolds and Péclet numbers, $Re_b = \alpha ^2 Re$ and $Pe_b = Pr …

Integrating Gis And Ca-Markov Model To Study Urban Dynamics Of Salem, India In Terms Of Pattern, Intensity And Direction, Linda Theres B

Theses and Dissertations

Urban populations have grown substantially in the modern era and the information age as people seek better living prospects. Currently, more than half of the world's population resides in the cities. Such growth must be monitored to ensure that people enjoy the boons of urban spaces, not the banes. Recognising the significance of urban studies, several researchers have attempted to analyse and predict urban dynamics using remote sensing, Geographic Information Systems, and machine learning methods. However, certain limitations exist, especially in improving the CAMarkov model's prediction performance. In addition, studies have suggested that growth characteristics, such as pattern, intensity, and …

Student Senate Meeting Minutes November 5, 2024, Student Senate-Winona State University

Student Senate Meeting Minutes

This document is the official Winona State University Student Senate Minutes for November 5, 2024.

Deep Reinforcement Learning For Adaptive Network Slicing In 5g For Intelligent Vehicular Systems And Smart Cities, Almuthanna Nassar, Yasin Yilmaz

USF Patents

Systems and methods for processing a service request within a network environment can include a first cluster of fog nodes that execute service tasks. The cluster can include a primary fog node and nearest neighbor fog nodes. The primary fog node can receive, from the network, a service request, determine service request resource data that includes a first time, quantity of resource blocks required to serve the request, and a hold time required to serve the request locally. An edge controller, connected to the network and the first cluster, can receive, from the primary fog node, the service request resource …

Advancing Drug Discovery And Disease Understanding Through Knowledge Graphs And Machine Learning Techniques, Swastika Tenkila Purushotham

Electrical and Computer Engineering ETDs

This thesis investigates knowledge graphs with particular reference to the NIH-funded Common Fund Data Ecosystem Data Distillery project. By combining data from nine Common Fund projects and other sources, this project has created a large knowledge graph using Neo4j. To find new and undiscovered drug targets, UNM’s Illuminating the Druggable Genome (IDG) Data Coordinating Center has supplied data and use cases. Condensed Knowledge Graph, a condensed version that is based on the Data Distillery Knowledge Graph, improves usability for IDG applications. Condensed Knowledge Graph research endeavors to enhance data organization through the categorization of disease terms, examination of Cerebellar Stroke …

Professor To Promote German As Exchange Ambassador, Edwin Smith

University of Mississippi News

OXFORD, Miss. – A University of Mississippi faculty member is the first from the state selected for a national program that promotes research and funding opportunities for American students and professors.