Digital Commons Network^™

Antimicrobial Activity And Photostability Of Cationic Conjugated Polyelectrolytes, Mohammed Ismael Khalil

Chemical and Biological Engineering ETDs

Antimicrobial resistance is a growing global health concern, driving the need for novel

therapeutic strategies. This study explores the antimicrobial efficacy of conjugated

polyelectrolytes (CPEs) and oligo-phenylene ethynylenes (OPEs) in bacterial and viral

inactivation. Quantitative analysis revealed that light-activated CPEs and OPEs

effectively reduced bacterial viability within minutes, with significant log reductions

observed under both light and dark conditions. Additionally, the antiviral potential of a

cationic conjugated oligomer was investigated, demonstrating rapid and near-complete

inactivation of SARS-CoV-2 under visible light, both in solution and on filter materials.

Further analysis of their photophysical properties revealed that, even after

photobleaching, the compounds …

Powering Up Clinical Practice: Mastering Clinical Literature Search Techniques In Embase, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

This presentation titled "Powering Up Clinical Practice: Mastering Clinical Literature Search Techniques in EMBASE" is a workshop designed to enhance healthcare professionals' skills in conducting effective clinical literature searches. It covers navigating EMBASE, transforming clinical questions into search concepts, developing advanced search strategies using keywords and Emtree terms, and applying techniques to optimize and evaluate search results. The workshop aims to improve participants' ability to efficiently utilize EMBASE for clinical decision-making and research purposes.

How Wildfires Threaten Water Resources: A Case Study Following The Largest Wildfire Recorded In New Mexico, Eric A. Joseph

Civil Engineering ETDs

Wildfire disturbance propagation along fluvial networks remains poorly understood. We use incident, atmospheric, and water-quality data from the largest wildfire in New Mexico’s history to quantify how this gigafire affected surface runoff processes and mobilized wildfire disturbances into fluvial networks after burning 1382 km². Surface runoff post-fire increased compared to pre-fire conditions, and precipitation events that are frequently observed in the affected watershed (<2-year recurrence) and fell during the post-fire first rainy season resulted in uncorrelated, less frequently observed runoff events (10-year recurrence). Wavelet coherence analysis highlighted that water quality disturbances propagated variably along the network, even at sites located >160 km downstream of the burn perimeter. Our findings emphasize the need to incorporate spatially resolved longitudinal sampling designs into wildfire water quality research and highlight the spatiotemporal co-dependency among atmospheric, terrestrial, aquatic processes …

Robust Data-Driven Run-To-Run Control Via One-Step Constrained Optimization For Automated Serial Sectioning, Rhianna M. Oakley

Mechanical Engineering ETDs

This Thesis develops a one-step predictive run-to-run controller (R2R-MPC) for automating a mechanical serial sectioning (MSS) system. MSS is a destructive material analysis process that iteratively removes slices of material and captures 2D images, reconstructing them into 3D representations. Commonly used in material science for characterizing materials and failure analysis, MSS typically operates in an open-loop fashion, which experiences high variability in material removal due to system disturbances. To address this, a robust closed-loop R2R-MPC is presented, modeling MSS process uncertainty using a linear differential inclusion identified from operational historical data. The R2R-MPC is posed as an optimization problem that …

From A Traditional City To A Smart City: The Measurement Of Cities’ Readiness For Transition, Egypt As A Case Study, Ahmed Hassebo, Mohamed Tealab, Mosaad Hamouda

Publications and Research

The transition from traditional legacy cities to smart cities represents a pivotal juncture in urban development and governance. As cities worldwide grapple with the challenges of rapid urbanization, resource constraints, and the need to enhance the quality of life for their citizens, the concept of a “smart city” has gained significant attention. This paper delves into the multifaceted process of urban transformation, shedding light on the essential criteria and considerations that guide a city’s conversion into a smart city. To provide a comprehensive framework for the conversion process, this paper outlines a computer program utilized to measure the readiness to …

Tumor-Infiltrating Mast Cells Confer Resistance To Immunotherapy In Pancreatic Cancer, Ying Ma, Xiangqin Zhao, Jingyan Feng, Suimin Qiu, Baoan Ji, Patrick Hwu, Huamin Wang

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) exhibits an immunosuppressive tumor microenvironment (TME) contributing to its therapeutic resistance. Following our previous studies, we report that mast cells infiltrating the PDAC TME foster this immunosuppression and desmoplasia. Mast cell infiltration correlated with human PDAC progression, and genetic or pharmacological mast cell depletion reduced tumor growth and desmoplasia while enhancing survival in mouse PDAC models. Mechanistically, mast cell-derived IL-10 promoted PDAC progression. Strikingly, combining an agonistic anti-OX40 immunotherapy with mast cell blockade synergistically elicited durable anti-tumor immunity, marked by increased infiltration of CD8

Low-Molecular Weight Cyclin E Confers A Vulnerability To Pkmyt1 Inhibition In Triple-Negative Breast Cancer, Mi Li, Amriti R Lulla, Yan Wang, Spyros Tsavaschidis, Fuchenchu Wang, Tuyen D T Nguyen, Marc A Pina, Mei-Kuang Chen, Sofia Mastoraki, Asha S Multani, Natalie W Fowlkes, Aysegul Sahin, C Gary Marshall, Kelly K Hunt, Khandan Keyomarsi

Faculty, Staff and Student Publications

Cyclin E is a regulatory subunit of CDK2 that mediates S phase entry and progression. The cleavage of full-length cyclin E (FL-cycE) to low-molecular weight isoforms (LMW-E) dramatically alters substrate specificity, promoting G1-S cell cycle transition and accelerating mitotic exit. Approximately 70% of triple-negative breast cancers (TNBC) express LMW-E, which correlates with poor prognosis. PKMYT1 also plays an important role in mitosis by inhibiting CDK1 to block premature mitotic entry, suggesting it could be a therapeutic target in TNBC expressing LMW-E. In this study, analysis of tumor samples of patients with TNBC revealed that coexpression of LMW-E and PKMYT1-catalyzed CDK1 …

Could Residential Air-Source Heat Pumps Exacerbate Outdoor Summer Overheating And Winter Overcooling In Uk 2050s Climate Scenarios?, Xiaoxiong Xie, Zhiwen Luo, Sue Grimmond, Yiqing Liu, Carlos E. Ugalde-Loo, Matthew T. Bailey, Xinfang Wang

School of Art, Design and Architecture

The UK government promotes heat pumps to replace gas boilers in the residential sector as a vital part of its strategy to achieve Net Zero by 2050. As climate change intensifies, heat pumps, traditionally used for heating, will also play a role in cooling to address indoor heat risks that threaten public health and increase energy demands. However, air-source heat pumps (ASHPs) might unintentionally exacerbate summer overheating and winter overcooling in residential neighbourhoods. This study uses a multi-scale modelling approach, combining SUEWS and EnergyPlus, to assess the impact of ASHPs on outdoor temperature in two idealised UK low-rise residential neighbourhoods …

Radiological And Elemental Composition Of Cryoconite And Glacier Mice From Vatnajökull, Iceland, Emma Smith, Caroline Clason, Geoff Millward, Alex Taylor, Ralph Fyfe

School of Geography, Earth and Environmental Sciences

Cryoconite has been demonstrated to be an efficient accumulator of some classes of contaminants on glaciers in both mountain and polar environments, however the accumulation of contaminants in cryoconite in Iceland has received very little attention to date. To understand the spatial variability of natural and anthropogenic fallout radionuclides and metals on glaciers in Iceland, we present the first study of this region including both cryoconite from three glaciers: Virkisjökull; Skaftafellsjökull; and Falljökull, together with moss balls (‘glacier mice’) from Falljökull. The cryoconite samples and glacier mice were analysed using XRF spectrometry to assess their elemental composition and gamma spectrometry …

Vertical Arrays Of Artificial Rockpools On A Seawall Provide Refugia Across Tidal Levels For Intertidal Species In The Uk, Jessica R. Bone, Rick Stafford, Alice E. Hall, Roger J.H. Herbert

School of Biological and Marine Sciences

Eco-engineering of coastal infrastructure aims to address the insufficient intertidal habitat provided by coastal development and flood defence. There are numerous ways to enhance coastal infrastructure with habitat features, but a common method involves retrofitting artificial rockpools. Often these are ‘bolt-on’ units that are fixed to existing coastal infrastructure but there is a paucity of literature on how to optimise their arrangement for biodiversity. In this study, 24 artificial rockpools were installed at three levels between High Water Neaps and Mean Tide Level on a vertical concrete seawall on the south coast of the UK. The species abundance of the …

Improving Employee Retention In The Virtual Workforce, Marissa Williams

Walden Dissertations and Doctoral Studies

The need for addressing employee retention in the virtual workforce is critical, particularly in the context of the U.S. General Services Administration (GSA) Region 4. High employee turnover rates can lead to significant disruptions and decreased organizational performance. This administrative case study involved identifying effective strategies to improve retention and engagement among virtual employees. The practice-focused question involved understanding key factors that influenced employee retention and developing actionable recommendations for the GSA. Insights can be applied across similar organizations facing virtual workforce challenges. Data were collected through in-depth surveys with employees that were hired between 2020 and 2023, focusing on …

The Experiences Of Veteran African American Military Officers With Social Influences On Promotions And Career Opportunities, Veronica Denise Green

Walden Dissertations and Doctoral Studies

While programs and procedures are in place in the US Military to increase diversity and inclusion of minorities and women in senior level positions, the problem is African Americans continue to remain below the relative national percentage rate compared to their White male counterparts. The purpose of this qualitative multiple case study was to explore African American veteran Military officers' experiences with promotion and access to career opportunities, and to identify how their social and cultural relationships influenced those opportunities. Khawaja’s theory of workplace relationships provided a lens into the key role of relationships in organizational conflict, teamwork, and inclusion …

Exceptional Points Induced By Unidirectional Coupling In Electronic Circuits, Wenzheng Zhao, Yeang Zhang, Zixuan Gao, Delong Peng, Jun Long Kou, Yan Qing Lu, Ramy El-Ganainy, Şahin K. Özdemir, Qi Zhong

Michigan Tech Publications

Exceptional points in non-Hermitian systems have attracted considerable attention due to their novel applications in several fields such as optics, electronics, and mechanics. Typically, exceptional points are constructed through gain and loss modulation or dissipative coupling within the framework of parity-time symmetry or anti-parity-time symmetry. Recent demonstration of unidirectional coupling in optical resonators to create exceptional points has offered an alternative approach. This study extends this concept to electronic circuits, examining exceptional points that emerge in unidirectionally coupled LC circuits. We show that this circuit undergoes resonance frequency splitting that exhibits either linear or square-root scaling with the strength of …

Trust-Me: Resource Allocation And Server Selection Based On Trust In Multi-Access Edge Computing, Sean Tsikteris

Electrical and Computer Engineering ETDs

Multi-access Edge Computing (MEC) is crucial for Internet of Things (IoT) applications by optimizing data processing and reducing latency. This thesis presents contributions to resource allocation and decision-making in edge computing environments. The TRUST-ME model is introduced, involving multiple edge servers and IoT devices (users) offloading computing tasks to MEC servers. A utility function is designed to assess latency and cost benefits for IoT devices using server resources. The core innovation is a novel trust model that evaluates IoT devices’ confidence in MEC servers by integrating both direct and indirect trust, based on interactions and feedback from other devices. In …

2024-11-15 Faculty Regent Report, Morehead State University. Faculty Senate.

Faculty Senate Records

A report submitted by the Faculty Board of Regent member to the Faculty Senate on November 15, 2024.

Mixed Reality Environment Selection Using A Virtual Object, Samuel Wu

Defensive Publications Series

A computer-implemented method comprising providing, within a first mixed reality environment, an environment selection user interface element; receiving, using the environment selection user interface element, an environment selection; and generating, according to the environment selection, a second mixed reality environment.

Structural Behavior Of Corroded Reinforced Concrete Beam Elements Repaired With Fabric-Reinforced Matrix Composites, Youssef Ibrahim Elmezayen

Thesis/ Dissertation Defenses

Advanced methods for rehabilitation of reinforced concrete (RC) beams with corroded reinforcement were designed and implemented in this research. The nonlinear flexural and shear behaviors of RC beams with corroded reinforcement repaired with fabric-reinforced matrix (FRM) composites were investigated. Numerical simulation models were developed to predict the flexural response of flexure-deficient continuous RC beams before and after repair with FRM composites. A novel sustainable repair solution that involves the use of cement-free geopolymeric matrix reinforced with nonmetallic fabrics was also introduced for rehabilitation of shear-critical RC beams with corroded stirrups. Simplified and easy-to-use analytical approaches were adopted to estimate the …

Utility Of New Remote Sensing Data In Evaluating The Hydrological Response To Land Use And Land Cover Changes, Chithrika Jayamini Alawathugoda

Thesis/ Dissertation Defenses

Land use and land-cover (LULC) changes have profound impacts on hydrological responses, influencing both runoff dynamics and flood risks. This study focuses on two contrasting environments undergoing rapid LULC transformations: the arid Wadi Ham watershed in the UAE and the tropical Imphal watershed in India. The study addresses the need for accurate LULC data in hydrological modeling, particularly in climate-sensitive regions where changes in land use are accelerating. The primary objective of this research was to assess the impact of LULC changes on the hydrological behavior of the Wadi Ham and Imphal watersheds. It aimed to elucidate how these changes …

Ossification Of The Yellow Ligament In The Cervical Spine – An Unusual Location, Jacob Yoong-Leong Oh, Victor Tzong-Jing Wang, Timothy Wei Wen Teo, Arun-Kumar Kaliya-Perumal, Hwan Tak Hee

BioMedicine

Ossification of the yellow ligament (OYL) or ligamentum flavum, usually occurs in the thoracic spine. Focal OYL occurring in the cervical spine is considered rare and is sparsely reported in the literature. We came across a 30-year-old male patient with progressive left upper limb and bilateral lower limb weakness over a period of 3 months, associated with an unsteady gait. Clinical examination revealed bilateral generalized hyper-reflexia in both upper and lower limbs, inverted supinator jerk, Hoffman’s sign and clonus. Myelopathy due to cord compression was suspected and further investigations were done. MRI and CT scans revealed a bony mass in …

Early Post-Surgical Recurrence Of Metastatic Vertebral Neuro-Endocrine Tumour Treated Effectively With Chemo-Radiotherapy, Arun-Kumar Kaliya-Perumal, Mark Tan, Seh Wee Tee, Shaam Achudan, Wai Ming Yap, Jacob Yoong Leong Oh

BioMedicine

No abstract provided.

Materials And Structures Used In Meniscus Repair And Regeneration: A Review, Ketankumar Vadodaria, Abhilash Kulkarni, E Santhini, Prakash Vasudevan

BioMedicine

No abstract provided.

The Effectiveness Of Stress-Management-Based Cognitive-Behavioral Treatments On Anxiety Sensitivity, Positive And Negative Affect And Hope, Sara Sahranavard, Aliakbar Esmaeili, Reza Dastjerdi, Hamid Salehiniya

BioMedicine

No abstract provided.

Mechanical Stretch And Chronotherapeutic Techniques For Progenitor Cell Transplantation And Biomaterials, Eve Helena Rogers, Vanja Pekovic-Vaughan, John Alan Hunt

BioMedicine

No abstract provided.

Only Lasers Can Be Used For Low Level Laser Therapy, Sergey Vladimirovich Moskvin

BioMedicine

No abstract provided.

Mesh Materials And Hernia Repair, Santhini Elango, Sakthivel Perumalsamy, Krishnakumar Ramachandran, Ketankumar Vadodaria

BioMedicine

No abstract provided.

The Contributions Of The Tissue Inhibitor Of Metalloproteinase-1 Genotypes To Triple Negative Breast Cancer Risk, Wen-Shin Chang, Liang-Chih Liu, Chieh-Lun Hsiao, Chen-Hsien Su, Hwei-Chung Wang, Hong-Xue Ji, Chia-Wen Tsai, Ming-Chei Maa, Da-Tian Bau

BioMedicine

No abstract provided.

Wound Dressings – A Review, Selvaraj Dhivya, Viswanadha Vijaya Padma, Elango Santhini

BioMedicine

No abstract provided.

An Overview Of Targeted Cancer Therapy, Viswanadha Vijaya Padma

BioMedicine

No abstract provided.

Mass Spectrometry-Based Proteomics In Chest Medicine, Gerontology, And Nephrology: Subgroups Omics For Personalized Medicine, Shih-Yi Lin, Wu-Huei Hsu, Cheng-Chieh Lin, Chao-Jung Chen

BioMedicine

No abstract provided.

Cross-Species Identification Of In Silico Microsatellite Biomarkers For Genetic Disease, Hao-Teng Chang, Yu-Yang Lo, Jhen-Li Huang, Wei-Yong Lin, Tun-Wen Pai

BioMedicine

No abstract provided.