Digital Commons Network^™

The Adenine Nucleotide Translocase Family Underlies Cardiac Ischemia-Reperfusion Injury Through The Mitochondrial Permeability Pore Independently Of Cyclophilin D, Dexter Robichaux, Jeffery D Molkentin, Jason Karch

Faculty, Staff and Students Publications

The mitochondrial permeability transition pore (mPTP) is implicated in cardiac ischemia-reperfusion (I/R) injury. During I/R, elevated mitochondrial Ca2+ triggers mPTP opening, leading to necrotic cell death. Although nonessential regulators of this pore are characterized, the molecular identity of the pore-forming component remains elusive. Two of these genetically verified regulators are cyclophilin D (CypD) and the adenine nucleotide translocase (ANT) family. We investigated the ANT/CypD relationship in mPTP dynamics and I/R injury. Despite lacking all ANT isoforms, Ca2+-dependent mPTP opening persisted in cardiac mitochondria but was desensitized. This desensitization conferred resistance to I/R injury in ANT-deficient mice. CypD is hypothesized to …

A Conserved Role For Alg10/Alg10b And The N -Glycosylation Pathway In The Sleep-Epilepsy Axis, Brittany S Leger, Bo Yang, Steven Tran, Kanjana Laosuntisuk, Jacqueline M Lane, Dalton Bannister, Chanat Aonbangkhen, Kiel G Ormerod, Belinda Mahama, Kelsey N Schuch, Carolyn Elya, Jamilla Akhund-Zade, Suraj R Math, Nicholas C Lorocco, Soobin Seo, Matthew Maher, Oguz Kanca, Nerses Bebek, Derya Karadeniz, Gulcin Benbir Senel, Carolina Courage, Anna-Elina Lehesjoki, John W Winkelman, Hugo J Bellen, Benjamin De Bivort, Anne C Hart, J Troy Littleton, Betul Baykan, Colleen J Doherty, Girish C Melkani, David A Prober, Christina M Woo, Richa Saxena, Stuart L Schreiber, James A Walker

Faculty, Staff and Students Publications

Congenital disorders of glycosylation (CDG) comprise a class of inborn errors of metabolism resulting from pathogenic variants in genes coding for enzymes involved in the asparagine-linked glycosylation of proteins. Unexpectedly to date, no CDG has been described for ALG10 , encoding the alpha-1,2-glucosyltransferase catalyzing the final step of lipid-linked oligosaccharide biosynthesis. Genome-wide association studies (GWAS) of human traits in the UK Biobank revealed significant SNP associations with short sleep duration, reduced napping frequency, later sleep timing and evening diurnal preference as well as cardiac traits at a genomic locus containing a pair of paralogous enzymes ALG10 and ALG10B . Modeling …

Sustainable Series Of New Epoxidized Castor Oil-Based Thermosets With Reprocessable Properties, Enanshu Chaudhari

Electronic Theses & Dissertations

This research will focus on the development and characterization of bio-based thermosets using epoxidized castor oil (ECO) and a range of dicarboxylic acids, namely 2,2'-dithiodiglycolic acid (DTGA), 3,3'-dithiodipropionic acid (DTPA), and 4,4'-dithiodibutyric acid (DTBA). The objective will be to synthesize environmentally sustainable thermosetting materials with tunable thermal and mechanical properties. The crosslinking between the epoxy groups in ECO and the carboxyl groups in the dicarboxylic acids will be confirmed using Fourier-transform infrared spectroscopy (FTIR), demonstrating the successful formation of ester linkages. Differential scanning calorimetry (DSC) will reveal that DTGA-based thermosets exhibit higher glass transition temperatures (Tg) due to shorter chain …

The Role Of Digital Transformation In Human Resources Flexibility: An Analytical Study At The Ministry Of Communications - General Company For Telecommunications And Information Technology, Ibtihal Ghaleb Ghulam, Ali Hassoun Al-Taie

Journal of Economics and Administrative Sciences

Purpose: The current research seeks to embody its primary objectives in diagnosing the relationship between the research variables (digital transformation, human resources flexibility), as well as defining the role of each of them in the General Company for Communications and Informatics. Theoretical Framework: This study deals with the General Company for Communications and Informatics and presents the latest concepts that previous researchers have reached to contribute to its achievement and expand the company's awareness by adopting any of these models appropriate to its goals and future direction. Design/Methodology/Approach: The study analyzes administrative data within the Ministry (2023-2024), using the dimensions …

An Overview Of Japanese Kampo: An Integrative Approach To Medicine, Olivia Yaste

Honors College Theses

There is a growing interest in the use of traditional medicine for the treatment of disease and health conditions around the world. The traditional medicine system of Japan has been in place for thousands of years and the traditional herbal system, Kampo, has been fully integrated into the modern national healthcare system. The compilation of information on topics surrounding Kampo written in English is scattered, making it difficult to gain a broad understanding of the subject without immense time and effort. This paper aims to review the existing literature on a variety of topics surrounding Kampo in order to give …

Board Of Trustees Minutes, Dec. 13 2024, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

Board Of Trustees Agenda, Dec. 13 2024, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

Revisiting The Impact Of Container Port Service Quality On Customer Satisfaction: A Configuration Approach, Saeyeon Roh, Haddoud M Yacine, Adah-Kole Onjewu, Hyunmi Jang, Vinh V. Thai

Plymouth Business School

In global port competitions, container port service quality (CPSQ) plays a critical role in determining user satisfaction and port competitiveness. Despite numerous empirical research efforts on the relationship between CPSQ and customer satisfaction, few studies have analysed the configurational effects of CPSQ on customer satisfaction. To address a gap in research, this study examines the factors that influence customer satisfaction among port users, including cargo owners and logistics service providers. The focus is on container ports in non-transshipment ports in South Korea, as well as a transshipment port in Singapore, which are representative of major global maritime countries. In this …

Decision Making And Performance Optimization In Distributed Cyber Physical Networks, Md Sahabul Hossain

Electrical and Computer Engineering ETDs

Cyber-Physical Systems (CPSs) integrate computation, networking, and physical processes, while Cyber-Physical Networks (CPNs) enable communication and coordination among components. With advances in IoT and smart devices, CPSs are increasingly vital for applications such as smart grids, industrial automation, and autonomous vehicles. This dissertation explores decision making and performance optimization in Distributed Cyber-Physical Networks (DCPNs), focusing on efficiency, reliability, decentralization, and security. Using network economic theories (e.g., game theory, contract theory) and machine learning (e.g., Reinforcement Learning, Federated Learning), it addresses key problems: 1) a cost-effective positioning system with Reconfigurable Intelligent Surfaces (RISs) and RL, 2) energy-efficient task offloading in Multi-access …

How Will Ai Impact Knowledge Sharing Within Construction Clustering? Bringing Back The Conversation On Social Contagion Within Construction Clusters, Oluwasegun O. Seriki, Mark Mulville, Ruairi Hayden

Conference Papers

Construction clusters and innovation systems play a crucial role in enhancing competitiveness and fostering sustainable development in the construction sector. These clusters facilitate knowledge sharing, interactive learning, and collaborative innovation among firms, institutions, and other stakeholders. The success of construction clusters depends on numerous factors, including firm size, economic climate, and attitudes towards innovation. While some clusters transform into innovation systems by becoming tacit-knowledge intensive, there is not much data or investigation into how they may adapt to changing demands spurred by advances in artificial intelligence (AI). There is some preliminary research highlighting the lack of dispersed innovation networks within …

Synergistic Adsorption Of Pb (Ii) From Aqueous Solution Using Calcined Biochar-Bentonite Clay Hybrid, Azeezat Faderera Abdul-Raheem

Theses and Dissertations

The biochar-bentonite clay hybrid was prepared by coprecipitation with the goal of producing a material that can remove Pb (II) from aqueous solutions effectively. Incorporating bentonite clay onto the Douglas fir biochar (DFB-BTC) surface significantly improved the adsorption capacity by introducing more active sites, strengthening the structural properties, and promoting strong adsorbate interactions. The point of zero charge of the adsorbent was slightly higher than that of the pristine DFBC. All sorption experiments were performed at pH 5, and the system obeyed the Langmuir adsorption isotherm. The highest Langmuir adsorption capacities observed at 298, 308, and 318 K were 48, …

Crystal Plasticity Modeling To Capture Microstructural Variations In Cold-Sprayed Materials, Aulora Gail Williams

Theses and Dissertations

The high-velocity impact of powder particles in cold-spray additively manufactured (CSAM) parts creates intersplat boundaries with regions of high dislocation densities and sub-grain structures. Upon microstructure and mechanical characterization, CSAM Aluminum 6061 showed non-uniformity, with spatial variation in the microstructure and mechanical properties affecting the overall response of the additively manufactured parts. Post-processing treatments are conducted in as-printed samples to improve particle bonding, relieve residual stresses, and improve mechanical properties. In this work, we attempt to implement the effects of grain size and distribution of smaller grains along the intersplat boundaries using the grain size distribution function and powder size …

Comparative Analysis Of Conventional And Non-Conventional Current Transformers: Advancements, Applications, And Implications For Modern Power Systems, Phalguni Morla

Theses and Dissertations

This thesis, titled "Comparative Analysis of Conventional and Non-Conventional Current Transformers: Advancements, Applications, and Implications for Modern Power Systems," examines the performance and challenges of conventional and non-conventional current transformers (CTs). Conventional CTs, while reliable in traditional power systems, face issues like core saturation, mechanical stress, and environmental limitations, making them less suited for modern, dynamic systems. Non-conventional CTs, such as optical and Rogowski coil-based transformers, offer higher accuracy and better adaptability, especially in digital applications like smart grids. Through experiments, the study compares the thermal performance, accuracy, and load-handling abilities of both CT types. Results show that while conventional …

Development Of Robotic Sampling Method For Rees In Gps-Denied And Hazardous Environments, Alan Arthur

Graduate Theses & Non-Theses

In recent times, the demand for rare earth elements (REEs) has been fueled by industry shifts towards energy efficiency and climate neutrality, as well as the great potential for the use of REEs in all sectors of our daily lives. Currently, China accounts for over 75% of global REE production (Dal, 2024). Various REE producers are gearing up to produce significant amounts of REEs to solve the issue of global supply and break China’s monopoly. A spike in REE prices of nearly tenfold in 2011 provided the impetus for accelerating over 400 REE exploration projects around the world (Barakos, 2017). …

Critical Mineral Recovery From Metals-Laden Mine Water, Matthew Ingersoll

Graduate Theses & Non-Theses

The importance of critical mineral possession has increasingly risen as the transition to clean energy becomes more viable. Critical minerals play many roles in national security, energy independence, environmental well-being, and economic growth. Given that many companies and certain countries have goals to halve greenhouse gas emissions by 2030, and reaching zero emissions by 2050, critical minerals have become a paramount resource and a focus in many research fields. Acid mine drainage and other mine wastewaters have been found to be viable sources of critical minerals with potential for recovery. This critical mineral recovery research focuses on zinc and manganese …

Experimental And Numerical Investigation Of Phase Change Material Melting Cycle In Microgravity, Ethan Michael Schuetzle

Theses and Dissertations

Efficient thermal management of spacecraft systems is crucial to overcome the extreme thermal conditions in space. Phase change materials (PCMs) offer significant advantages in thermal energy storage (TES) systems due to their high latent heat of fusion, the amount of energy stored or released during phase transitions. However, PCMs face limitations due to low thermal conductivity, especially in microgravity where heat transfer is primarily through conduction. This research addresses this issue by incorporating a 3D-printed aluminum lattice structure to enhance heat transfer to PCMs. Experimental data from sub-orbital flight tests and ground-based experiments, coupled with numerical simulations, are used to …

The Effect Of Teacher Efficacy On Career Technical Education Program Participation In Select Mississippi Schools, Lori Parkman Nail

Theses and Dissertations

The primary purpose of this study was to determine to what degree school staff understood the benefits and outcomes of Career Technical Education programs and how this level of understanding impacted Career Technical Education program enrollment in five selected schools in Mississippi. The levels of understanding keyed in on three pivotal factors. First, perceptions of the availability and accessibility of Career Technical Education programs to students in the participating schools were measured. Second, the perceptions of the benefits students reap from being involved in Career Technical Education programs were examined. Next, the perceptions of the benefits Career Technical Education programs …

Engineering Functionalized Nanomaterials For Targeting And Ablating Biofilms On Surfaces, Dhanush Lakmal Yapa Amarasekara

Theses and Dissertations

Biofilms on both the surface and interior of medical devices pose major challenges, including hindering device performance and serving as infection sources. These biofilms form a protective layer around bacteria, shielding them from the body’s immune system and antibiotics. This makes infections difficult to treat, as the bacteria within the biofilm are resistant to both antibiotics and immune defenses. Additionally, biofilms can induce inflammation and irritation in nearby tissues, leading to further health complications. Antibiotic resistance raises concerns about the emergence of multi-drug resistant (MDR) pathogens. MDR infections are difficult to treat, leading to prolonged hospital stays and the need …

Effects Of A Snap-Ed Social Marketing Campaign On Behavior Change, Andrew Beall Cole

Theses and Dissertations

Introduction: This research studied the use of a social marketing campaign to address chronic diseases in the U.S., such as obesity, diabetes, hypertension and other cardiovascular diseases by assessing audience self-reported actions and evaluating message framing effects on participant intentions to change nutrition behavior and daily physical activity. Approach: Evaluate a social marketing campaign for effects on SNAP-Ed eligible clients and research message framing effects on audience’s intention to change health behaviors. Discussion: The HappyHealthy social marketing campaign launched in 2018 by Mississippi State University Extension. Outcome evaluation data (collected 2023) reported multiple correlations between core messages recalled and increased …

The Digital Divide Among Urban University Students In The Post-Pandemic Era, J. B. Oleet

Theses and Dissertations

This survey study, N = 44 university students, from an urban campus, measured post-pandemic digital divide perceptions, focusing on motivational, physical, skills, and usage access to ICTs through the lens of van Dijk’s resources and appropriation theory. Statistical tests, including one-sample t-tests, correlation analyses, one-way and repeated measure ANOVAs, and independent sample t-tests, highlighted both the perceptions and relationships among different dimensions of digital divides. The findings showed that participants perceive their post-pandemic digital divide perceptions positively. Intrinsic Motivational Access (IMA) mean scores were particularly high, suggesting a strong internal drive among students to engage with ICTs, significantly surpassing extrinsic …

Predicting Vegetation Override Force For Off-Road Autonomy, Marc Nicholas Moore

Theses and Dissertations

Vegetation override is an important aspect of off-road ground vehicle mobility. An autonomous ground vehicle’s (AGV) perception system must distinguish between vegetation that can be easily driven through from vegetation that cannot. Predicting the resistance of vegetation could allow path- planning systems to make this distinction. However, despite its importance, direct measurement of vegetation resistance is rare, as most studies use indirect proprioceptive data, such as inertial measurements, as proxies for override force. Notably, there is a lack of empirical data on the override resistance of small stems (< 2.5 cm) and clusters of vegetation on medium-sized (approx. 1000kg) vehicles. To address this gap, a comprehensive dataset of override measurements was collected for clumps of small vegetation relevant to intermediate-sized AGVs navigating off-road terrain. This dataset includes over 70 recordings using the Robot Operating System (ROS) during controlled driving experiments through small trees, grasses, and bushes. The collected data includes light detection and ranging (LiDAR) scans, imagery, force measurements from integrated load cells, and simultaneous localization and mapping (SLAM) information. A key contribution of this research is the development and calibration of a custom push bar system equipped with load cells to directly measure override forces. These measurements are compared to empirical models previously developed by the U.S. Army Corps of Engineers for larger single-stem vegetation. A preprocessing pipeline was developed to automatically extract and label LiDAR and camera data according to these force measurements. This self-labeled dataset was then used to train machine learning models that predict override resistance of vegetation from LiDAR and camera scans alone. This research characterizes the relationship between override forces and the observable features of vegetation as measured by LiDAR and camera sensors. Deep learning models were developed and trained to predict override forces based on different input modalities and features derived from point clouds and images. The performance of these models was compared across various input features to investigate how deep learning can create a generalizable and accurate force prediction system.

Eco-Friendly Polyester Vitrimer: Enhanced Stretchability, Self-Healing, And Reprocessability Through Dynamic Covalent Crosslinks Via Melt-Polycondensation, Saiprasanna Neerukonda

Electronic Theses & Dissertations

Dynamic covalent polymer networks offer new possibilities for designing sustainable polyester vitrimers owing to their excellent reprocessability and malleability; however, maintaining the high performance of the adaptable network with amazing healing properties remains a challenge. Therefore, the proposed approach considers the one-pot synthetic strategy to fabricate highly stretchable polyester vitrimer networks via condensation polymerization of different aliphatic diacids which are glutaric acid, pimelic acid, azelaic acid with 1,4-butanediol in the presence of glycerol and dithiodicarboxylic acids as the curing agent and dynamic covalent crosslinkers. The synthesized polyester network with simultaneous disulfide metathesis and carboxylate transesterification exhibited vitrimeric behavior which can …

Flourine Free, Bio-Based Antismudge Polyurethane Coating With Enhanced Flame-Retardancy, Rutu Patel

Electronic Theses & Dissertations

Antismudge coating materials are generally synthesized using petroleum-based polyols and fluorinated compounds, which are harmful to the environment and human health. Thus, researchers are more inclined to develop polyurethane (PU) coating from bio-based polyols and fluorine-free materials. Here, silicone-containing diol was used with soybean oil polyol (SOP) to produce PU coating. The chemical inertness to acid, base, and salt, along with the non-stick properties of silicone, would help achieve the desired properties of the anti-smudge PU coating. Metal (stainless steel) and wood coupons (oak wood) were coated with this synthesized coating material and tested to study chemical resistance along with …

Effect Of Nitrogen And Phosphorus In Rigid Polyurethane Foams Synthesized From Bio Derived Polyol, Jonsi Patel

Electronic Theses & Dissertations

Rigid polyurethane foams (PUFs) are widely used as thermal insulators due to their excellent mechanical properties and low thermal conductivity. However, their dependence on petrochemical-derived polyols and inherent flammability poses environmental and safety challenges. This study investigates the synthesis of bio-based rigid PUFs using canola oil polyol (COP), a sustainable alternative to petrochemical polyols. The research explores the incorporation of nitrogen and phosphorus-based reactive flame retardants, including diethyl phosphate (DEP), melamine (MA), and a novel compound (TDHTPP) synthesized from cyanuric chloride, diethyl phosphate, and vanillin, to enhance both flame retardancy and mechanical properties. Preliminary results demonstrate that PUFs containing 15gm …

Fictional And Historical Narratives Of African American Soldiers Of Wwii, Abigail Rae Stewart

Honors Theses

This thesis examines the experiences of African American soldiers during World War II through the dual lenses of oral histories and fictionalized accounts, arguing that both are essential to fully understanding their multifaceted journeys at home and abroad. Oral histories provide direct, personal narratives from veterans themselves, capturing their voices, emotions, and reflections on the discrimination, camaraderie, and resilience that defined their wartime and postwar lives. These firsthand accounts offer invaluable insights into the structural realities of systemic racism within the military and society, as well as the personal sacrifices these soldiers made in the name of a country that …

On Food And Restaurants, Liya Cui

Capstones

This portfolio contains a collection of stories about New York City restaurants and broader food culture, including reported features, a profile and criticism. Food is literally inescapable; even if you believe you don’t care about what you eat, every bite is a choice. This subject deserves critical thought and exploration as it influences our lives in myriad ways and reveals cultural trends that can tell us so much about who we are right now.

https://medium.com/@LiyaC/capstone-portfolio-on-food-and-restaurants-bc4c18c7f2a9

Making Music And Making Rent: The New Wave Of New York City’S Working Class Artists, Hannah J. Fierick

Capstones

Though New York’s local music scene has become a shadow of its former self, the city’s musicians have found creative ways to stay afloat while doing what they love. This piece explores the music scene in New York today through interviews with working class musicians themselves.

The Fashion Regulation Fight, Eliot L. Force

Capstones

Fast fashion is a rising global phenomenon with terrible consequences for the environment and laborers across the world. In the US, fashion-specific environmental and labor regulation is practically non-existent at the federal level, but some individual states have begun proposing fashion regulation bills with the aim of curbing the industry’s harms. But in every state where these regulations have been proposed, powerful industry trade groups and companies have been fighting back against those proposed regulations, with much success, through lobbying. As climate change gets worse and the fashion industry’s practices remain unchanged, the need for regulation only becomes greater, but …

Courting Success

DePaul Magazine

DePaul men’s basketball shoots for a comeback with new head coach Chris Holtmann and a revitalized program.

Evaluation Of Implementing Clinical Partnerships For Fourth Semester Bachelor Of Science In Nursing (Bsn) Students And Employers On Perception Of Readiness To Practice, Gwendolyn Kay Chrisenbery

Doctor of Nursing Practice Scholarly Project

An Abstract of the Scholarly Project by

Gwendolyn K Chrisenbery MSN, APRN, FNP-C

Abstract

Today’s new graduate nurses are entering a complex and constantly evolving healthcare environment. Nursing education has not kept up with the changing environment, resulting in graduate nurses not being ready to practice at graduation. To better prepare graduate nurses for practice, education methods must evolve with the changing demands of healthcare (National Academies of Sciences, Engineering, and Medicine, 2021). Utilizing clinical partnerships between universities and healthcare facilities to provide clinical experience to Bachelor of Science in Nursing (BSN) students could provide opportunities for learning that better …