Digital Commons Network^™

Regulated Drug Delivery Via Controlled Degradable Chondroitin Sulfate Particles, Nurettin Sahiner, Ramesh Ayyala

USF Patents

Disclosed herein are crosslinked chondroitin sulfate particles crosslinked chondroitin sulfate particle polyelectrolytes. The particles are useful in drug delivery applications. The particles may be used to treat various conditions, including bacterial and fungal infections.

Digital Twin And Cybersecurity In Additive Manufacturing, Lidong Wang

Journal of Cybersecurity Education, Research and Practice

Additive manufacturing (AM) has been applied to automotive, aerospace, medical sectors, etc., but there are still challenges such as parts’ porosity, cracks, surface roughness, intrinsic anisotropy, and residual stress because of the high level of thermal gradient. It is significant to conduct the modeling and simulation of the AM process and achieve quality products. Digital Twin (DT) can help AM with forecasting defects/errors through simulation and real-time process monitoring. DT is a concept of Industry 4.0, and its digital structure reflects the real-time behaviors of a cyber-physical or physical system. This paper introduces the progress of DT applications in AM, …

Determination Of The Kinetic Parameters Of Cholesterol Oxidation Using Cholesterol Oxidase From Streptomyces Sp., Meka Saima Perdani, Heri Hermansyah, Muhamad Sahlan, Dwini Normayulisa Putri, Teguh Pambudi, Anggi Khairina Hanum Hasibuan

Makara Journal of Technology

Cholesterol oxidase (CO) was successfully produced from Streptomyces sp. via the submerged fermentation method, and 69 U/mL enzyme activity was obtained. This study aimed to determine cholesterol oxidation kinetics and the production of CO as a catalyst. The enzyme was diluted to 0.15, 0.075, and 0.00375 U/mL for the oxidation reaction. The substrate was also prepared in three concentrations: 3.23, 6.46, and 12.93 mM. The optimization of conditions for enzymatic cholesterol oxidation was investigated through measurement of the effect of initial cholesterol and enzyme concentrations. Cholesterol concentration was rapidly measured via high-performance liquid chromatography (HPLC). The kinetics of CO were …

Generative Ai In Shariah Advisory In Islamic Finance: An Experimental Study, Muhammad Noman Jokhio, Muhammad Asif Jaffer

Business Review

Islamic banks adhere strictly to Shariah principles in all operations and offerings, creating a demand for experts proficient in Shariah-compliant banking and finance. This study investigates the potential of using generative AI, specifically Large Language Models (LLMs), to provide Shariah advisory in complex Islamic financing scenarios. The research evaluates general purpose public LLMs—such as ChatGPT, Gemini, and Meta AI—on their ability to identify Shariah compliance issues, cite relevant Shariah references, and propose actionable guidance for resolving compliance challenges in complex Islamic financing scenarios. A qualitative approach was used. The experimental study involved creation of complex, realistic financing scenarios requiring Shariah …

Glucose-Lowering Agents Developed In The Last Two Decades And Their Perioperative Implications, Basavana Goudra, Geno Merli, Michael Green

Department of Anesthesiology Faculty Papers

The last two decades have provided far more options f both patients and their physicians in the treatment of diabetes mellitus. While dipeptidyl peptidase-4 inhibitors (DPP-4is) and glucagon-like peptide 1 receptor agonists (GLP-1RAs) have been approved for nearly two decades, sodium-glucose cotransporter 2 inhibitors (SGLT-2is) are relatively new. Of interest to perioperative physicians, these drugs present specific perioperative concerns, prompting many societies to issue guidelines. Retained gastric contents due to slow gastric emptying is a significant drawback of GLP-1RAs, increasing the risk of aspiration. Recommendations include withholding GLP-1RAs for a predefined period of time, performing gastric ultrasound to evaluate gastric …

Muqarnas In Damascus: A Forgotten Treasure’S History, Inception And Geometry, Nahed Jawad Chakouf

All Works

The architecture of the Islamic world encompasses both religious and secular buildings that are unified by the use of a common architectural language, which includes architectural elements such as minarets, domes and arches, ornamental details, and vaulting with the use of muqarnas. The study provides a broad overview of the development of Islamic architecture, focusing on Damascus, the early Islamic period, the mid-Islamic period and the late Islamic period. The late Islamic period includes Ottoman art, with architecture influenced by Byzantine, Persian, Armenian, and Mamluk artefacts, but differs from their predecessors. The researcher undertook a geometric analysis of the muqarnas …

New Graduate Nurses' Experiences Of Burnout As They Transition To Practice, Stacy Beth Elliott

Walden Dissertations and Doctoral Studies

Transitioning from nursing school to professional practice is a critical and challenging period for newly graduated nurses. Transition to professional nursing practice is particularly stressful in the first 3 years as new graduates adapt to the high acuity of patient care, which can result in burnout. The purpose of this qualitative study, guided by the conservation of resource theory, was to understand how new graduate nurses describe their experiences of burnout as novice nurses transition in the first 3 years of nursing practice. Fourteen nurses were interviewed using a semi-structured interviews, and Saldana’s two-cycle analysis was used for data interpretation, …

Targeted Degradation Of Oncogenic Krasg12v Triggers Antitumor Immunity In Lung Cancer Models, Dezhi Li, Ke Geng, Yuan Hao, Jiajia Gu, Saurav Kumar, Christina C Kuismi, Yuanwang Pan, Fiona Sherman, Asia M Williams, Yiting Li, Fei Li, Ting Chen, Cassandra Thakurdin, Michela Ranieri, Mary Meynardie, Daniel S Levin, Janaye Stephens, Alison Chafitz, Joy Chen, Mia S Donald-Paladino, Jaylen M Powell, Ze-Yan Zhang, Wei Chen, Magdalena Ploszaj, Han Han, Shengqing Stan Gu, Tinghu Zhang, Baoli Hu, Benjamin A Nacev, Medard Ernest Kaiza, Alice H Berger, Xuerui Wang, Jing Li, Xuejiao Sun, Yang Liu, Xiaoyang Zhang, Tullia C Bruno, Nathanael S Gray, Behnam Nabet, Kwok-Kin Wong, Hua Zhang

Faculty, Staff and Student Publications

Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most frequently mutated oncogene in lung adenocarcinoma, with G12C and G12V being the most predominant forms. Recent breakthroughs in KRASG12C inhibitors have transformed the clinical management of patients with the G12C mutation and advanced our understanding of the function of this mutation. However, little is known about the targeted disruption of KRASG12V, partly due to a lack of specific inhibitors. Here, we leverage the degradation tag (dTAG) system to develop a KRASG12V-transgenic mouse model. We explored the therapeutic potential of KRASG12V degradation and characterized its effect on the tumor microenvironment (TME). …

An Ontology-Based Approach For Understanding Appendicectomy Processes And Associated Resources, Xubing Hao, Licong Cui, Ping Yu

Faculty, Staff and Student Publications

Background: Traditional methods for analysing surgical processes often fall short in capturing the intricate interconnectedness between clinical procedures, their execution sequences, and associated resources such as hospital infrastructure, staff, and protocols.

Aim: This study addresses this gap by developing an ontology for appendicectomy, a computational model that comprehensively represents appendicectomy processes and their resource dependencies to support informed decision making and optimise appendicectomy healthcare delivery.

Methods: The ontology was developed using the NeON methodology, drawing knowledge from existing ontologies, scholarly literature, and de-identified patient data from local hospitals.

Results: The resulting ontology comprises 108 classes, including 11 top-level classes and …

New Graduate Nurses' Experiences Of Burnout As They Transition To Practice, Stacy Beth Elliott

Walden Dissertations and Doctoral Studies

Transitioning from nursing school to professional practice is a critical and challenging period for newly graduated nurses. Transition to professional nursing practice is particularly stressful in the first 3 years as new graduates adapt to the high acuity of patient care, which can result in burnout. The purpose of this qualitative study, guided by the conservation of resource theory, was to understand how new graduate nurses describe their experiences of burnout as novice nurses transition in the first 3 years of nursing practice. Fourteen nurses were interviewed using a semi-structured interviews, and Saldana’s two-cycle analysis was used for data interpretation, …

Providing Enhanced Learning In Llms By Associating Data With Role-Based Source Information, Laxmi Mukund, Shraddha S K

Defensive Publications Series

In today's fast-paced world, the rapid introduction of new product features necessitates accurate and timely documentation. Traditional manual documentation methods are inefficient, error-prone, and often result in outdated information. Techniques are presented herein to address these challenges by leveraging Large Language Models (LLMs) to automate the generation of precise and reliable documents by associating data with well-defined role-based source information. The impact of this solution goes beyond generating documentation for new features; it can also be extended to enable targeted stakeholder interactions, to identify speakers in recorded conversations, and to classify unclassified dialogues.

The Anxious Generation, How The Great Rewiring Of Childhood Is Causing Epidemic Of Mental Illness, Jay Nathan

Journal of Global Awareness

No abstract provided.

Nappy, Loc’D Or Straight, It Still Gets Hate: A Collaborative Autoethnography Examining Black Hair In K-12 Education And Beyond, Maiya Turner, Janae Alexander-Bady, Virginia Redwine Johnson, Salandra Grice, Tyra Montour

Journal of Multicultural Affairs

The purpose of this study is to examine the impact that Black hair discrimination has on Black girls in K-12 educational settings. Black hair has long been tied to Black girls and women’s cultural identities. However, Black girls often fall victim to discrimination based on their hair texture and style, which can often impact their relationship with their hair through adulthood. Utilizing collaborative autoethnography, we provide our hair experiences during our K-12 educational experiences and how this has impacted our current relationships with our hair. Additionally, within the findings, we identify three themes common among our experiences: dress codes as …

Damn The Dams: Framing ‘Schizophrenic’ Discourses Of The Hindu Right, Nandita Ghosh

Critical Humanities

This article examines the concept of schizophrenia as a cultural metaphor in order to analyze the Hindu Right’s contradictory language-framing politics within the public domain, particularly in relation to building mega dams on rivers Narmada and Bhagirathi. In so doing, it intends to examine the nature of the public domain itself that enables such framing politics within the context of late 20^th-early-21^st-century global capital. Language battles in the public domain have intensified during this period, especially through various forms of digital media. In India, the various groups that form the Hindu Right have often mixed the …

Functionalism, Algorithms And The Pursuit Of A Theory Of Mind For Artificial Intelligence, Victor Mureithi

Critical Humanities

Abstract.

The advancement of computing technology has given rise to an interesting thesis: the human brain can be studied and understood as operating on the principles of a digital computer. The claim later became a more substantial thesis: the Mind is a computer since the Mind is actualized in the brain. The recent success of large language models (LLMs) such as Bard (produced by Google), GPT3, ChatGPT (also known as GPT3.5, produced by OpenAI-Microsoft), and LLaMA (produced byMeta) has brought greater attention and focus to the discussion of human versus machine intelligence. The result has been a pursuit of a …

Design Method For Power Efficiency Optimization Of Zonal Illuminated Projector, Ted Cym

Defensive Publications Series

A method is provided for optimizing a power efficiency of an illuminator including a plurality of illumination zones that are individually addressable for providing a zonal illumination at a non-emissive display panel. The method includes calculating a plurality of illumination powers of the illuminator for a plurality of zone layouts of the illuminator, each zone layout including a number of the zones included in the illuminator, a size of the illuminator, and a color sub-zone configuration for each of the plurality of illumination zones. The method also includes selecting a zone layout with a lowest illumination power of the illuminator.

Design Method For Power Efficiency Optimization Of Zonal Illuminated Projector

Defensive Publications Series

A method is provided for optimizing a power efficiency of an illuminator including a plurality of illumination zones that are individually addressable for providing a zonal illumination at a non-emissive display panel. The method includes calculating a plurality of illumination powers of the illuminator for a plurality of zone layouts of the illuminator, each zone layout including a number of the zones included in the illuminator, a size of the illuminator, and a color sub-zone configuration for each of the plurality of illumination zones. The method also includes selecting a zone layout with a lowest illumination power of the illuminator.

System And Method To Authorize A Payment Transaction Using A Digital Glove, Sri Sai Krishna Kiran Atmuri

Defensive Publications Series

The present disclosure relates to a system and method to authorize a payment transaction using a digital glove. The present disclosure suggests tapping a cardholder’s digital glove on a merchant payment system without entering a Personal Identification Number (PIN) to initiate a payment transaction. The merchant payment system transmits the payment transaction data to an issuer system through a network via an acquirer server for authorization. Upon notification, the cardholder enters the PIN by performing a sequence of pinches between a thumb finger distal phalange and the other finger phalanges of the digital glove. Thereafter, encrypt the chronological order of …

Exploring Blockchain Technology: Applications And Insights Across Multiple Fields, Zarella Valentina Burbano Vallejo, Edgar Dario Obando Paredes

AUIQ Technical Engineering Science

Blockchain is a digital recording technology where each block contains encrypted data linked to previous blocks, forming an immutable and transparent sequence. This review systematically analyzes the applications and evolution of blockchain technology across multiple sectors from 2021–2023. peer-reviewed articles focused on key areas such as finance, healthcare, energy, and supply chain management. The findings highlight blockchain's transformative potential, including its ability to enhance security through encryption and decentralization, improve trust and data integrity, and eliminate intermediaries, enabling faster transactions and cost reduction. However, challenges such as scalability issues, high energy consumption in cryptocurrency mining, privacy concerns due to the …

A Statewide Geographic Information System (Gis) As A Predictive Tool For Locating Deeply Buried Archeological Deposits In Nebraska: Phase Iii-The Sandhills Region, Anthony L. Layzell, Rolfe D. Mandel, John Swigart, David T. Williams

Nebraska Department of Transportation: Research Reports

This project developed a GIS to assist with the identification of deeply buried cultural deposits in alluvial settings across the Sandhills region of Nebraska. Soil survey data, previous geoarchaeological investigations, landform position, and other information was used to rank the potential of any stream valley setting as low, low-moderate, moderate-high, or high potential to contain buried cultural deposits. While the presence of buried soils does not necessarily translate to presence of buried archeological sites, the potential for such sites is far greater in buried soils. The GIS can be used by NDOT and other agencies with statutory historic preservation obligations, …

Editorial: Artificial Intelligence For Smart Health: Learning, Simulation, And Optimization, Bing Yao, Nathan Gaw, Hyo Kyung Lee

Faculty Publications

With rapid developments in medical sensing and imaging, we now live in an era of data explosion in which large amounts of data are readily available in clinical environments. The fast-growing biomedical and healthcare data provide unprecedented opportunities for data-driven scientific knowledge discovery and clinical decision support. Our Research Topic aims to catalyze synergies among biomedical informatics, machine learning, computer simulation, operations research, systems engineering, and other related fields with three specific goals: (1) develop cutting-edge data-driven models to accelerate scientific knowledge discovery in biomedicine using healthcare data collected from laboratory systems, imaging systems, and medical and sensing devices; (2) …

Editorial: Infrastructure Maintenance And Monitoring For Sustainable Cities, Yonas Kassa, Saeed Eftekhar Azam, Deepak Khazanchi, Brian Ricks

Faculty Publications

As cities continue to grow and evolve, maintaining and monitoring their infrastructure becomes an 2 increasingly challenging problem, requiring multidisciplinary approaches. This problem is as critical for 3 developing countries that are rapidly building their infrastructure (Gurara et al., 2018Ede et al., 2019) 4 as it is for already developed countries with aging infrastructure (Van Breugel, 2017). Researchers have 14 Such developments can also be integrated into digital twinning-a technology approach that creates 15 virtual replicas of physical infrastructure elements, systems, and cities-that offers a dynamic framework 16 for real-time monitoring and predictive maintenance through data integration and simulation. The …

Enhancing Data-Driven Decisions By Improving Nonprofit Transparency And Collaboration: A Study Of The Accessibility Of Nonprofit Data In The Global Landscape, Angie Holzer, Beverli Dewalt, Louis Ye

Journal of Nonprofit Innovation

This paper addresses the pressing need for enhanced transparency of nonprofit data to improve nonprofit collaboration, emphasizing the development of a global nonprofit database. Globally, there is a lack of transparency and accessibility to nonprofit data, which reduces the ability to make better decisions 1) between nonprofits as they work to collaborate and improve outcomes, 2) with nonprofit resource providers (foundations, volunteers, donors, company CSR programs, governments, grantees, etc.) when making decisions about who to support, and 3) with nonprofits as they attempt to reach those who need their services. By analyzing 34 nonprofit databases from the European Union, the …

Butte Priority Soils Operable Unit (Bpsou) Final Bpsou Insufficiently Reclaimed Sites Belle Of Butte (Bres No. 8 & Ur-39) Remedial Action Work Plan (Rawp) Request For Change Ir- 2024-Ra-02, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

“A Disturbing Portent Of Future Harm”? Attacks On Cultural Heritage, Atrocity Crimes, And The Problem Of Prevention, Matthew S. Weinert

Genocide Studies and Prevention: An International Journal

Preventing atrocities has garnered significant scholarly and practitioner attention. In 2014, the UN Office of Genocide Prevention issued a Framework of Analysis of Atrocity Crimes listing 14 risk factors and 143 indicators to support risk analysis and early action. Cognizant that conflicts regularly include deliberate attacks on cultural heritage, the Framework identifies fourteen indicators that pertain to culture and cultural heritage. Five years after the Framework’s release, Simon Adams decried the international community’s ineffectiveness at translating early warning into practical action with respect to cultural heritage. Instead of focusing on lack of political will or obstructionism—an obstructionism that led to …

Evaluation Of Impact Energy In Composites Using Acoustic Emission Sensing Technique, Li Ai, Tanner Mesaric, Sydney Flowers, Sydney Houck, Joshua Widawsky, Paul Ziehl

Faculty Publications

A major challenge faced by composite materials is impact, which can result in unexpected damage and degradation. Impact events can cause significant structural damage that may not be immediately visible, leading to a reduction in the material’s mechanical properties and overall performance. This paper presents an impact assessment method using acoustic emission (AE) sensing technology. The primary goal of this approach is to determine the extent of impact damage on composite components by analyzing AE signals produced under operating stress conditions. An advanced algorithm is proposed to predict the probability that the damage falls into various damage categories, providing a …

Optimizing Transport Predictive Modeling With Simulation-Based Statistical Inference Authors, Mamunur Rashid, Quyen Tran

Mathematics Faculty Publications

Simulation-based statistical inference (SBI) leverages computer simulations to help scientists understand and analyze complex data. This paper explores how SBI techniques can be used to analyze transportation data. We use modern computational methods, including machine learning models, to improve the accuracy of predictions and decision-making in transportation planning. Our study focuses on two SBI methods, Approximate Bayesian Computation - Markov Chain Monte Carlo and Synthetic Likelihood, to create synthetic data for training machine learning models. These models show the potential of SBI to handle uncertain transportation data. It also highlights the practical benefits of SBI in making better decisions for …

If Only Justice Could Heal Or Make Whole: Hard Lessons From Rwanda’S Legal Responses To Genocide And Mass Atrocity, Gerald Gahima

Genocide Studies and Prevention: An International Journal

My reflections on the limits of legal responses in Rwanda stem from both academic and lived experience. I served as Rwanda’s Deputy Minister of Justice (1996–1999), Prosecutor General (1999–2003), and Deputy Chief Justice (2003–2004) during the period after the genocide. In those roles, I had access to a large volume of information drawn from policy- making roles, case files of members of my staff, as well as my own fieldwork relating to the suffering of victims of the genocide. While I obviously believe that justice for those crimes is not in vain, my work with survivors left me with an …

Butte Priority Soils Operable Unit Sbcca Principles For A Greener Cleanup Report, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Narrative Engineering: Tools, Computational Structure, And Impact Of Stories, Michael A. Debuse

Theses and Dissertations

Computational Linguistics has a long history of applying mathematics to the grammatical and syntactic structure of language; however, applying math to the more complex aspects of language, such as narrative, plot, scenes, character relations, causation, etc. remains a difficult topic. The goal of my research is to bridge the narrative humanities with mathematics, to computationally grasp at these difficult topic, and help develop the field of Narrative Engineering. I view narrative and story with the same mathematical scrutiny as other engineering fields, to take the creativity and fluidity of story and encode it in mathematical representations that have meaning beyond …