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Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Final Bpsou Insufficiently Reclaimed Sites Belle Of Butte (Bres No. 8 & Ur-39) Remedial Action Work Plan (Rawp) Request For Change Ir-2024-Ra-02 (Dated December 19, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Organ-On-A-Chip Platforms For Drug Development, Cellular Toxicity Assessment, And Disease Modelling, Muhammad Maaz Khurram, Göktürk Ci̇nel, Özlem Yeşi̇l Çeli̇ktaş, Erdal Bedi̇r

Turkish Journal of Biology

Organ-on-a-chips (OoCs) or microphysiological platforms are biomimetic systems engineered to mimic organ structures onto microfluidic devices for biomedical research. These microdevices can mimic biological environments that enable cell-cell interactions at a small scale by mimicking 3D in vivo microenvironments outside the body. Thus far, numerous single and multiple OoCs that recapitulate organs have been developed, and they have emerged as forerunners for drug efficacy and cytotoxicity testing. This review explores OoC platforms to portray their versatility in investigating drug safety, efficacy, and toxicity. We also reflect upon the potential of OoCs to effectively demonstrate disease models for probable novel therapeutics, …

Combinational Therapy Of All-Trans Retinoic Acid (Atra) And Sphingomyelin Induces Apoptosis And Cell Cycle Arrest In B16f10 Melanoma Cancer Cell, Zeynep İşlek Köklü, Eli̇f Li̇dya Şanverdi̇, Başak Karadağ, Mehmet Hi̇kmet Üçişik, Ezgi̇ Taşkan, Fi̇kretti̇n Şahi̇n

Turkish Journal of Biology

Background: Melanoma arises from the uncontrolled multiplication of melanocytes, posing an escalating global health concern. Despite early detection and surgical removal being crucial, metastatic melanoma poses treatment challenges, with limited options like chemotherapy and immunotherapy. All-trans retinoic acid (ATRA), a natural metabolite of vitamin A, has shown promise in melanoma treatment by inducing differentiation, apoptosis, growth arrest, and immune modulation. However, ATRA treatment alone can lead to resistance and relapse. Sphingomyelin (SM) also plays a role in inhibiting melanoma progression by apoptotic cell death.Objective: This study investigated combinational anticancer effects of ATRA and SM on in vitro B16F10 melanoma cells.Method: …

Mechanistic Insights Into Cardiac Regeneration And Protection Through Meis Inhibition, Aynura Mammadova, Gali̇p Servet Aslan, Li Mo, Qifang Wu, Sebastian Clauss, Fati̇h Kocabaş

Turkish Journal of Biology

MEIS1, a member of the TALE-type homeobox gene family, has emerged as a pivotal regulator of cardiomyocyte cell cycle arrest and represents a promising therapeutic target. Our study reveals that inhibition of MEIS1 using two novel small molecules, MEISi-1 and MEISi-2, significantly enhances neonatal cardiomyocyte proliferation and cytokinesis. Specifically, MEISi-1 and MEISi-2 increased the proportion of proliferating cardiomyocytes (Ph3+TnnT cells) upto 4.5 fold and the percentage of cytokinetic cardiomyocytes (AuroraB+TnnT cells) by 2 fold, compared to untreated controls. MEIS1 inhibition resulted in a notable downregulation of MEIS1 target genes and cyclin-dependent kinase inhibitors, demonstrating its effect on key regulatory pathways. …

Wood-Plastic Composites Integration For Triboelectric Nanogenerator Electricity Generation, Hanbyeol Park, Razamala Yashna F. Dimaporo, Sophia Maureen A. Emperado, Anton Jefferson L. Pangilinan, Juan Carlo T. Gumangan

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Access to electricity in underdeveloped communities is particularly crucial in improving the living standards of people and alleviating poverty by promoting sustainable development. This study deals with the exploration of incorporating wood-plastic composite (WPC) – specifically wood pulp (W) and high-density polyethylene (H) – into triboelectric nanogenerator (TENG) flooring system to convert mechanical energy to electrical energy, promoting sustainable energy, reducing greenhouse gas emissions, improving the quality of life, and serving as feasible flooring tiles. Two types of TENG tiles were prepared by using different WPC ratios: 30W:70H and 70W:30H. A static bending test was conducted to assess the flexural …

A Protection Or A Barrier? A Scoping Review Of Boundaries In Teacher-Student Relationships, Joseph Russell R. Santos

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Teacher-student relationships have differing potentialities in terms of importance and challenges, therefore implying the need for more effective navigation by placing healthy boundaries. However, the impact of this relationship and the boundary itself for both teachers and students need to be recognized to determine how they should be navigated. Doing so can give teachers and students healthier and more meaningful classroom experiences that align with the sustainable development goal of achieving optimal well-being and quality education. To examine the perceived importance and challenges of boundaries in teacher-student relationships, a scoping review was conducted. Eleven (11) out of the 29 studies …

Self-Agency As A Strategy In Emergency Remote Learning Among Filipino Grade 10 Students, John Cris C. Tababa, Paul Andrei C. Apo, Golden Grace R. Gammaru, Audrey S. Manaay, Kathrin Anne N. Nadua, James Fhonzy Angelo S. Fontillo

Sinaya: A Philippine Journal for Senior High School Teachers and Students

The Coronavirus disease 2019 pandemic significantly influences students' educational attainment as they actively find and rationalize knowledge obtained from emergency remote learning. As a response, the agency or the ability to regulate one’s learning provides the students with the ability to believe in themselves. Still, it also necessitates the deliberate consideration to create a plan of action and modify it as required to achieve one's objectives. This study obtained knowledge from emergency remote learning (ERL) experiences of Filipino Grade 10 Students in their Social Studies class. The researchers employed a phenomenological approach to understand the self-agency practices of Grade 10 …

Citation Practices Of Contrasting Cultures In Q1 Journal Articles, April Rose C. Gonzales

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Citation is a distinguishing feature in research writing that every researcher must include to ensure credible ethical research. Citing sources is necessary as it provides credit to the original author, refers to previous findings, sets credibility, and enables sustainability of the topic. However, studies least consider culture as an element that influences citation beliefs and practices. Most literature holds a lack of language proficiency as the culprit for poor citation skills. Drawing from Hofstede's Cultural Dimension theory (2011) and Lewis’ (2006) Cultural Behaviour in Relation to Writing, this study explores the influence of culture on citation practices with the hope …

Exploring Student Engagement In A Blended And Gamified Statistics And Probability: Designed With Learning Styles And Player Types, Reymund R. Gonowon

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Educators are called to contribute towards achieving SDG 4: Quality Education. A major determinant in achieving this goal is providing learners with essential skills such as analyzing and interpreting data, making inferences, and driving evidence-based decisions which are the expected competencies in Statistics and Probability (STATPRO), one of the core subjects of the senior high school curriculum in the Philippines. To progress towards SDG 4, achieving the learning competencies of STATPRO is vital, however engaging students in a blended learning environment may be challenging. This study aims to explore the behavioral engagement of students in a gamified STATPRO class through …

Optimal Operation Scheduling Of Integrated Energy System Considering Energy Priority, Dongli Jia, Keyan Liu, Zhaoying Ren, Zezhou Wang, Dongsheng Tang

Journal of System Simulation

Abstract: Integrated with the actual situation of power grid and the growth of new energy, a multiobjective model for optimal scheduling of the integrated energy system(IES) is established based on the analysis of the energy-flow relationship of the IES and taking into account the priority of energy utilization and the load demand response in terms of the mismatch between the distributed energy sources and the loads, the net benefit of the unit cost of the IES, and the load response degree. Combined with the equipment and the environmental benefits system, a priority constraint for energy utilization has been established for …

Research On Scheduling Strategies Simulation For Building Air-Conditioning Systems Based On Transfer Imitation Learning, Qiaochu Wang, Yan Ding, Chuanzhi Liang, Haozheng Zhang, Chen Huang

Journal of System Simulation

Abstract: To solve the problem of unstable performance and inefficient training process of low-quality data conditions at the initial stage of online deployment of air conditioner scheduling, we propose a migration-imitation learning-based air conditioning scheduling strategy simulation method. Reinforcement learning methods are used to generate building operation strategies. A standard building simulation model serves as the source domain, upon which migration learning is applied. An imitation learning loss function is incorporated into the intelligent loss function to enhance algorithm performance. The results indicate that, compared with the non-use of migration learning, the proposed method can improve the operational efficiency by …

Behavioral Modeling Of Manned-Unmanned Cooperative Air Combat Based On Improved Abc Algorithm, Peng Wang, Haoyu Liu, Ni Li, Zexi Yu, Shangjie Jia

Journal of System Simulation

Abstract: To solve the problem of difficulty in establishing collaborative behavior models and weak adversarial capabilities in typical MAV/UAV air combat scenarios, a mixed decision based MAV/UAV behavior modeling framework is proposed. Using collaborative rule sets, rule subsets, tactical action sets, and other tools, a hierarchical decision collaborative behavior model supporting five types of collaborative tactics, including grinding tactics and unilateral flanking tactics, is constructed in this framework. a behavior model parameter optimization method based on an improved artificial bee colony (ABC) algorithm is proposed. By using the Mason rotation method to initialize the population, a better initial honey source …

At The Core Of Apple And Antitrust: Interoperability, Antoine Bremond

Seattle Journal of Technology, Environmental, & Innovation Law

This paper offers a novel approach to analyzing Apple Inc, (Apple) within the context of antitrust law. As a frequently named party to antitrust litigation, not only in the United States but also worldwide, Apple’s closed garden has already been called into question. However, similar to the U.S. Department of Justice’s (DOJ) attempt on March 21^st, 2024 to “to erect a new landmark decision” in their lawsuit against Apple, this paper focuses on Apple’s iOS ecosystem as a whole. While this article recognizes similar consumer harm concerns the DOJ addresses in United States, et al. v. Apple Inc …

Defining The Social Licence Of Large Language Models In Healthcare, Robin L. Pierce, Jack Gallifant, Ashley Cordes, Amelia Fiske, Matilda Dorotic, Mataroria Lyndon, Shrey Jain, Joe Zhang, Judy Gichoya, Leo Anthony Celi

Seattle Journal of Technology, Environmental, & Innovation Law

As Large Language Models (LLMs) continue to grow and evolve, the ethical, social, and legal challenges they present, especially in terms of data use and sharing, come sharply into focus. Particularly in high-risk domains like healthcare, where the sensitivity of data is pronounced, and the ramifications of data leakages or misuse are profound. These licenses, envisioned to address the complexities introduced by LLMs, still grapple with barriers that hinder their full potential: notably, the absence of authoritative regulatory bodies, ambiguities in defining what constitutes 'sufficient public benefit', issues of data sovereignty, and dilemmas surrounding responsibility and liability. Herein, we delve …

Engineering Biomaterial Interfaces For Microbial Control, Yikang Xu

Dissertations - ALL

Since its inception as early as ancient Chinese placing bamboo pegs in place of missing teeth over 4,000 years ago, biomaterials have been an indispensable component of medical tools at human’s disposal. While early implants rely solely on the material properties themselves, modern devices have become much more than just materials. Topographic features, coatings, surface energy, and even embedded electronics have all added dimensions to the complexity of biomaterials and medical devices. Interaction between these materials and host cells and tissues, as well as microbes that can cause infections. Although well recognized for its significance, controlling biomaterial associated infections is …

Privacy Protection In Machine Learning Via Exploitation Of Constrained Adversarial Evasion, Brian Testa

Dissertations - ALL

Deep neural networks are extensively applied to real-world tasks. In many cases, the data feeding these tasks are human generated content, which emphasizes the criticality of privacy and data protection. The diverse modalities of this user data provide fertile ground for 3rd parties to monetize a user’s data. This work considers two such modalities: user speech when interacting with smart speaker voice assistants (VAs) and images shared with online service providers. In these cases, the user would like to support some form of machine learning (ML) inference without allowing others. A user interacting with a smart speaker would like the …

Elementary Science Instruction: A Document Analysis Of Teacher Messaging Across Two Sets Of Curriculum Materials, Jessica Mary Whisher-Hehl

Dissertations - ALL

Elementary teachers are tasked with teaching multiple subjects within an instructional day. One mechanism to support this task is through strong curriculum materials, which lay out a course of instruction aligned with instructional standards. This is helpful when teachers are trying to teach to a new set of standards, such as the Next Generation Science Standards, which require a significant shift in instructional strategies. In cases such as this, educative features embedded in the curriculum materials can assist teachers in making the required shifts in instruction. However, sometimes the instructional time required by curriculum materials, especially in elementary science, is …

Effects Of Negative Poisson’S Ratio On The Mechanics Of Auxetic Carbon Fiber Composites Under Tensile, Buckling And Low Velocity Impact, Wenhua Lin

Dissertations - ALL

Carbon fiber reinforced polymer (CFRP) matrix composites exhibited superior properties, such as high specific stiffness and specific strength, excellent fatigue and corrosion resistance, and low coefficient of thermal expansion, have been popular across various industries including aerospace, marine, automotive, energy, civil infrastructure, and high-end sports over the past decades. However, one significant drawback of CFRP composites is the susceptibility to low velocity impact damage which, for aircraft, can be results of tool drop, runway debris, and bird strike during takeoff and landing. These impact events could lead to external and internal damages of a CFRP composite structure in various damage …

Cognitive Load Classification From Functional Near-Infrared Spectroscopy Data, Jiyang Wang

Dissertations - ALL

Predicting cognitive workload using physiological sensors, such as functional near-infrared spectroscopy (fNIRS), has gained significant attention in recent years. However, many existing methods are limited by small datasets and narrow brain channel coverage, restricting their generalizability across participants, tasks, and sessions. In this thesis, we introduce two innovative approaches aimed at overcoming these limitations: a CNN-BiGRU model with self-supervised label augmentation (SLA) and a block-wise domain adaptation method (BWise-DA). Our CNN-BiGRU-SLA model, grounded in cognitive load theory, leverages attention mechanisms and multi-label classification to predict working memory load (WML) and visual processing load (VPL) across multiple participants and sessions. Using …

Vimentin Inside And Outside The Cell: From Cell Spreading To Nuclear Mechanics To Covid-19, Maxx Swoger

Dissertations - ALL

Cells are constantly subjected to both external forces encountered from the extracellular environment and internal stresses generated by the cell necessary to migrate and undergo healthy cellular function. Central to the ability of cells to both generate and mediate forces is the cell cytoskeleton, which forms the muscles and bones for cells. There are three main components of the cell cytoskeleton: microtubules, actin, and intermediate filaments. The role of actin and microtubules in cell function, particularly force generation and mediation have been well studied; however, the role of intermediate filaments is less understood. Intermediate filaments represent a broad and diverse …

Thermodynamics And Shear Flow Dynamics Of Block Copolymer Morphologies In Solution, Senyuan Liu

Dissertations - ALL

Block copolymers (BCPs) have been a focal point of research for several decades. They have been engineered to produce various morphologies by altering the combinations of chemically distinct polymer segments that interact selectively with their environment, such as in aqueous or organic solvents, or within a polymer matrix. The ability to tailor morphological features by manipulating polymer chain length, composition, and monomer chemistry has led to applications in advanced material manufacturing, catalysis, emulsification, environmental remediation, targeted drug delivery, gene therapy, and medical diagnostics. Consequently, understanding the relationship between copolymer architecture and the self-assembled morphologies at equilibrium, the pathways of structure …

In The Wholeness Of Time, Ethan Brue

Faculty Work Comprehensive List

"In a world that urges us to consume time, how do we change our approach, moving from simply passing time to filling it with holiness and patience that reflects God's character?"

Posting about ­­­­­­­­a Christian perspective on time from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

In the Wholeness of Time

Data For: Examining The Impacts Of Demographics, Individual Experiences, And Perceptions On Range Anxiety And Electric Vehicle Road Trips, Joshua Ward, Patrick A. Singleton, Antje Graul, Zane Regan

Browse all Datasets

Electric Vehicle Road Trip Study: These data contain anonymized responses to a survey designed to investigate the experiences, perceptions, barriers, and opportunities identified by electric vehicle (EV) drivers regarding road trips to recreational areas (like national parks) and for recreational activities.

Evolving Uk Biology Education, Helen R. Watson

Peninsula Medical School

School science curriculum reform is underway in the UK. Whilst each of the four devolved nations is at a different stage in this process, it is clear we are entering an era of opportunity for positive change, where curricula can be updated to reflect our current understanding of science and to better prepare learners for further study, work, and modern life more broadly.

From Sampling To Simulating: Single-Cell Multiomics In Systems Pathophysiological Modeling, Alexandra Manchel, Michelle M. Gee, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

As single-cell omics data sampling and acquisition methods have accumulated at an unprecedented rate, various data analysis pipelines have been developed for the inference of cell types, cell states and their distribution, state transitions, state trajectories, and state interactions. This presents a new opportunity in which single-cell omics data can be utilized to generate high-resolution, high-fidelity computational models. In this review, we discuss how single-cell omics data can be used to build computational models to simulate biological systems at various scales. We propose that single-cell data can be integrated with physiological information to generate organ-specific models, which can then be …

Neuvac: Nonlinear Extreme Ultraviolet Irradiance Model For Aeronomic Calculations, Daniel A. Brandt, Aaron J. Ridley

Michigan Tech Publications

The need for reliable estimates of solar extreme ultraviolet (EUV) for operational space weather nowcasting and forecasting has motivated the development of new model of solar irradiance variability in 59 wavelength bins between 1 and 1,750 Å. The model employs a nonlinear parameterization of rebinned daily FISM2 irradiances and is termed NEUVAC: Nonlinear Extreme Ultraviolet Irradiance Model for Aeronomic Calculations. The model is parameterized in terms of F10.7 and 54-day averaged F10.7 in a backwards-looking window. The model takes advantage of the high accuracy and resolution of FISM2, and the consistent availability of F10.7 data in order to provide the …

Harmonic Impedance Modeling And Oscillation Analysis Of Modular Multilevel Converter, Yuhong Wang, Wensheng Chen, Shilin Gao, Jianquan Liao, Yangfan Cheng

Journal of System Simulation

Abstract: To facilitate rapid analysis of the oscillation stability mechanism in modular multilevel converter-based high voltage direct current (MMC-HVDC) systems and streamline the simulation process for determining MMC impedance characteristics, a simplified mathematical simulation model for MMC closed-loop impedance is developed using the harmonic state space method. This model considers various control strategies and includes both AC-side and DC-side impedance models. By applying a Nyquist criterion-based impedance analysis method, the stability mechanisms on the AC and DC sides of the MMC are examined. In addition, a data-driven oscillation stability analysis method is also proposed, leveraging a global sensitivity algorithm based …

Path Planning Of Desert Robot Based On Deep Reinforcement Learning, Ming Li, Wangzhong Ye, Jiehua Yan

Journal of System Simulation

Abstract: Due to the complexity and variability of the desert environment, the key to the high-efficient of mobile robot is how to avoid obstacles and plan its path. To solve the problems of poor search efficiency and slow convergence of deep reinforcement learning algorithm in complex environment, an improved deep reinforcement learning path planning algorithm is proposed. The exploration factor is improved and dynamically adjusted according to the convergence degree of the algorithm, so that the exploration factor dynamically decreases with the increase of the understanding degree of the agent to the environment, thus speeding up the convergence speed of …

Investigating Catalytic Conversion Of Lignin To Valuable Products, Jialiang Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Lignin is a complex, random, and heterogeneous biopolymer in lignocellulosic biomass. It has significant potential for conversion into valuable chemicals and fuels. However, its natural recalcitrant structure has made selective depolymerization challenging. This dissertation presents a detailed investigation into the mechanisms of lignin disassembly and structural evolution under various catalytic and solvent conditions. The research spans three key studies. In Chapter 2, operando magic-angle spinning (MAS) solid-state nuclear magnetic resonance (NMR) spectroscopy was employed to study reaction pathways and kinetics of lignin model polymers during catalytic hydrogenolysis. We used a Ni-Al2O3 catalyst in methanol under high temperature and pressure, and …