Digital Commons Network^™

Additive Manufacturing Of Zinc-Based Biomaterials: Fabrication, Performance And Property Evaluation, S. Bandekian, M. Zolfaghari Baghbaderani, J. Drelich, S. Sharif, A.F. Ismail, H. R. Bakhsheshi-Rad

Michigan Tech Publications

The use of zinc and its alloys in additive manufacturing has become an important focus in interventional medical field. This is because zinc as an implant is naturally degradable, has solid mechanical characteristics, and is biocompatible. Biodegradable Zn-based metals made with additive manufacturing offer significant advantages in creating personalized medical implants. This review aims to provide an overview of different types of additive manufacturing methods and processes that can be used in the fabrication of Zn-based medical implants. It offers a comprehensive understanding of additive-manufactured Zn-based alloys for interventional surgeries. The study also summarizes the relationships between degradation properties, mechanical …

Game Changing Education: Empowering High School Stem Teachers To Teach Engineering Using Games, Leslie Brown

All Graduate Theses and Dissertations, Fall 2023 to Present

In response to the Next Generation Science Standards (NGSS) released in 2013, there was a nationwide push for K-12 schools to include engineering concepts in science classrooms. However, there is an overall lack of teacher preparedness and training towards engineering topics as shown by common engineering misconceptions. To improve this issue, I initiated a qualitative study to describe the strategies and attitudes of high school science, technology, engineering, and mathematics (STEM) teachers that have implemented game-based, engineering activities into their classroom. Game-based learning is an instructional framework that utilizes game-like elements in a classroom and was used in this study …

Adversarial Voltage Transients In Multi-Tenant Fpga Environments, Andrew J. Gerber

All Graduate Theses and Dissertations, Fall 2023 to Present

A Field Programmable Gate Array (FPGA) is a special type of computer chip that can be reconfigured to implement a nearly unlimited number of functions. Recent trends have led some companies to offer cloud-based FPGA solutions. Researchers are exploring how to properly secure multi-tenant environments where the designs from two or more customers are placed on the same FPGA with logical and spatial isolation, though multi-tenancy is not yet commercially available in cloud FPGAs. The digital circuits within an FPGA require a clock to synchronize timing within the design. The maximum speed that this clock can run at is determined …

Scheduling Charging For Fleets Of Battery Electric Vehicles: Techniques For Modeling And Real-Time Operation, Justin J. Whitaker

All Graduate Theses and Dissertations, Fall 2023 to Present

While electric vehicles (EVs) are becoming increasingly popular and can provide cost, maintenance, and environmental benefits, they present unique challenges for regular operation, especially in fleets of vehicles. The limited range, long charging times, and high power requirements of EVs complicate the operations of fleets comprised of EVs. Additionally, the charging costs of EVs can be complex, depending on the time of charging, the energy charged, and the power level of the charging session. These complex charging costs can be significantly affected by the presence of uncontrolled loads. These challenges are further complicated by the inevitable variations in the real …

Aerobic Biodegradation Of Algae-Derived Bioplastics Under Controlled Composting Conditions, Clayton J. Lords

All Graduate Theses and Dissertations, Fall 2023 to Present

Plastics are versatile polymers that have become critically important materials in many industries. Although plastics are important and useful materials, they account for vast amounts of environmental pollution and climate change contribution. Sustainable bioproducts are becoming increasingly important in the effort to mitigate the impacts of pollution and climate change. The scale of environmental damage caused by plastic pollution highlights the need to implement sustainably sourced biodegradable plastics within the global economy. Bioplastics are materials that may be manufactured from biological materials or can biodegrade under certain conditions. Algae are microorganisms that can be grown using nutrient-rich municipal wastewater; the …

Analyzing Microalgae-Bacteria Population Changes In Response To Environmental Parameters For Improved Wastewater Treatment, Amanda M. Moravek

All Graduate Theses and Dissertations, Fall 2023 to Present

Microalgae are incredible organisms that have a variety of uses such as wastewater treatment, fertilizer, livestock feed, and bio-compound production. Microalgae require a light source and minimal nutrients space to proliferate, making them an environmentally friendly and sustainable option for such processes. The Sustainable Wastes-to-Bioproducts Engineering Center at Utah State University is developing and implementing a Rotating Algae Biofilm Reactor (RABR) to remove total nitrogen and phosphorous from the Central Valley Wastewater Reclamation Facility wastewater effluent. Harmful compounds such as nitrates and phosphates are metabolized by the microalgae and converted into useful bioproducts, resulting in a circular economy. These RABRs …

Water Use By Irrigated Turfgrass And Connections To Climate And Biophysical Processes, Karem Meza

All Graduate Theses and Dissertations, Fall 2023 to Present

Urbanization and limited water supply and storage result in imbalanced urban water budgets. Quantification of water use becomes important in urban landscapes because urban turfgrass requires a significant amount of water and competes with other urban requirements. Evapotranspiration (ET) plays a crucial role in determining irrigation needs. Credible measurements and spatial estimates of urban turfgrass ET are needed for urban water management. However, these have not been addressed in urban landscapes in arid and semiarid regions. Despite estimating spatial urban turfgrass ET, turfgrass quality linked to ET has not been widely evaluated. Due to different environmental conditions, the driving forces …

Effects Of Light Intensity On Algae Biofilms In Rotating Algae Biofilm Reactors (Rabr), Joshua D. Wintch

All Graduate Theses and Dissertations, Fall 2023 to Present

There is a growing need for economically and ecologically friendly wastewater treatment processes. Utilizing natural algae biofilms to remediate excess nitrogen and phosphorus from municipal wastewater is a treatment technique of academic interest. Utilizing natural algae in rotating algae biofilm reactors (RABR) is a potential engineering application of algae biofilms for municipal wastewater anaerobic digestor effluent treatment. The ideal reactor operation would use sunlight as the light source for algae growth, however, there is little academic research on algae biofilm growth productivity across natural sunlight light intensity ranges. This research seeks to understand the relationship between rotating algae biofilm reactor …

Quantifying The Threshold For Fragmentation Of Newtonian And Non-Newtonian Drops, Aditya Parik

All Graduate Theses and Dissertations, Fall 2023 to Present

This dissertation investigates how the properties of liquid drops influence the minimum aerodynamic forces needed to cause the drop to fragment (breakup). For this work, we focus only on aerodynamic forces that are applied on a stationary drop by a sudden, uniform flow, a process called impulsive acceleration. Previous studies have largely focused on the fragmentation of spherical drops of Newtonian fluids (liquids with constant viscosity, like water), when impulsively accelerated in air-like ambient medium. Such systems only capture a limited range of drop and ambient properties (described by non-dimensional groups). Many real-world applications, such as aerial fire retardant delivery, …

Calculation Of Aerodynamic Surface Sensitivities Using The Adjoint Method In A Subsonic/Supersonic Panel Code, Nathan H. Hoch

All Graduate Theses and Dissertations, Fall 2023 to Present

An aircraft’s shape has a direct impact on the lift and drag it produces. In the early stages of designing an aircraft on a computer, engineers work to improve aircraft performance and efficiency by considering various shapes and configurations. Engineers use computer programs to analyze different designs and predict how each would perform in real-world conditions. Once an approximate aircraft shape is selected, adjustments to the shape can further improve the aircraft’s lift and drag characteristics. Engineers calculate a set of values called sensitivities that indicate which parts of the geometry should be changed to increase lift or reduce drag. …

Contrastive Representation Learning For Highly Imbalanced Multivariate Time Series With Extreme Instance Strategy, Onur Vural

All Graduate Theses and Dissertations, Fall 2023 to Present

Time series data refers to a sequence of data points collected or recorded at regular time intervals. In many fields including space weather, healthcare, and finance, predicting events from such data is crucial because these predictions can help protect infrastructures, improve healthcare outcomes, and forecast financial trends. However, one challenge in working with time series data is the presence of rare events, which are often underrepresented in the data. This imbalance makes it difficult for traditional prediction methods to provide accurate results, as they tend to focus more on the more frequent events and overlook the rare ones. To tackle …

Lidar Scene Reconstruction Using Imagery And Frame Overlap From A Texel Camera, Blake Chamberlain

All Graduate Theses and Dissertations, Fall 2023 to Present

A small unmanned aerial vehicle (sUAV) can be used to reconstruct a large area of terrain by capturing 3D scans, consisting of LiDAR point clouds and an overlaid image, and combining the scans together. Forming a complete 3D scene using texel image data (fused LiDAR and digital image scans) from an entire flight can be computationally prohibitive on low-cost hardware, so combining registering scans is done using a streaming method which processes the scans in consecutive chunks. Depending on the flight pattern, matching points in the scene may be visible from scans which were not captured around the same time, …

Uv-A Light And Heat-Activated Antimicrobial And Biodegradable Materials For Food Packaging And Preservation, Michael J. Bodily

All Graduate Theses and Dissertations, Fall 2023 to Present

Current food packaging materials are often non-biodegradable and harmful for ingestion, which poses a threat to the environment and public health. Thus far, the dangers of microbial contamination of food on human health have outweighed the risks associated with using these conventional packaging plastics. A possible solution to these issues is to use a combination of innovative materials and microbial inactivation methods that can potentially both reduce plastic waste and combat harmful microorganisms. In this study, two antimicrobial, biodegradable composites were developed and tested for their ability to inactivate two types of bacterium, Escherichia coli K12 and Listeria innocua, …

A Laboratory Study On The Hydraulics Of Stepped Spillways: Effects Of Step Geometry And A Labyrinth Crest, Megh Raj K C

All Graduate Theses and Dissertations, Fall 2023 to Present

Observed trends in extreme storms are affecting the safety of several embankment dams. Spillways are critical for safely conveying excess water in the reservoir over the dam and into the downstream river, yet many dams that were built over 40 years ago have undersized spillways to handle modern flood estimates requiring repairs and upgrades. Consequently, a unique spillway crest, the labyrinth weir, has been used as a cost-effective improvement for numerous projects to enhance discharge capacity of existing weirs. Another cost-effective option for overtopping protection due is to place a less expensive concrete, Roller-Compacted Concrete (RCC), over the dam to …

Greater Sage-Grouse Habitat Dynamics And Grazing, A Study Of Vegetation Indices And Survival, Codi R. Backen

All Graduate Theses and Dissertations, Fall 2023 to Present

North American rangelands are vast, open landscapes that support diverse ecosystems and provide many ecosystem services. Many wildlife call sagebrush rangelands home, including the Greater sage-grouse (sage-grouse; Centrocercus urophasianus). Sage-grouse habitat encompasses 165 million acres across western North America, and this bird has been of conservation concern as their populations drastically declined since the 1960s. Rangelands are also grazed by livestock, which has the potential to negatively affect sagebrush ecosystems when overgrazed or overstocked, which could be detrimental to sage-grouse nesting habitat. Additionally, sagebrush rangelands undergo annual variations in precipitation, temperature, growing season length, and vegetation vigor, which has …

Advancing Multi-Agent Robotics Simulations Through Heterogeneous Reinforcement Learning In Isaaclab, Jacob R. Haight

All Graduate Theses and Dissertations, Fall 2023 to Present

Robots increasingly operate in collaborative teams across domains such as search-and- rescue, warehouse automation, and autonomous driving—scenarios that demand advanced coordination strategies enabled by multi-agent reinforcement learning (MARL). However, existing simulation frameworks often struggle to balance realism, speed, and scalability, especially when supporting diverse, heterogeneous robot teams. This research extends Isaac Lab, a high-performance robotics simulator, by integrating heterogeneous-agent reinforcement learning (HARL) capabilities. The result is a flexible and GPU-accelerated platform for training both homogeneous and heterogeneous robot teams in complex, physics-based environments. These enhancements significantly narrow the gap between simulation and real-world deployment for multi-robot systems.

Gone With The Flow: Flow Reduction Coincides With Reduced Metabolism And Standing Stock Of Benthic Algae And Macroinvertebrates In Desert Rivers, Chloe E. Lyles

All Graduate Theses and Dissertations, Fall 2023 to Present

River metabolism, the measure of energy flow in a river, is driven by hydrological and physicochemical regimes (e.g., temperature, turbidity, and nutrients). However, these regimes are increasingly altered by human water demand and climate change-driven drought. These stressors alter the magnitude, timing, and duration of critical spring-snowmelt floods with poorly understood consequences on ecosystem function, particularly in desert rivers. To investigate the linkages between flow reduction, river metabolism, and basal food resource productivity (i.e., algae and aquatic invertebrates), we measured metabolism and basal resource availability in seven desert tributaries with varying degrees of flow reduction during low-flow conditions in 2023 …

Learning Intentions, Success Criteria, And Metacognition: The Influence Of A Professional Development For Grades Three To Five Teachers, Jason Hart

All Graduate Theses and Dissertations, Fall 2023 to Present

Formative assessment is a strategy that teachers use to improve student learning. This study explored how professional development focused on assessment for learning practices (AFL), with the main emphasis on learning intentions and success criteria, influences teacher use of those strategies and changes in teacher and student metacognition. The overarching research question was: How does professional development on AFL practices influence teachers' reported use of AFL practices and teacher and student metacognition? This study utilized a mixes-methods research design and provided professional development on AFL practices to 16 in-service elementary mathematics teachers and measured changes to their AFL practices and …

Irrigation Performance Connection To Water Quality In Big Creek, Sena Bildim

All Graduate Theses and Dissertations, Fall 2023 to Present

Due to new technologies and improved water management strategies, sprinkler irrigation systems are becoming more common in Utah and nearby areas. These systems are generally thought to be more efficient, but their effects on water quality are not well understood. This study focuses on the Big Creek watershed, which flows into Bear Lake—an area where water quality concerns are increasing.

The purpose of this research was to explore how different irrigation systems—sprinkler and surface—affect both water use and water quality. Field tests were conducted to measure how evenly water was applied and how efficient each system was. Water and soil …

Determining The Structure And Function Of Type Iv-A Anti-Crisprs, Olivine Redman

All Graduate Theses and Dissertations, Fall 2023 to Present

Bacteria face a constant existential threat in the form of infection by viruses along with other forms of mobile genetic elements, such as bacteriophage and transposable elements. To survive, bacteria and other prokaryotes have evolved various immune systems to evade these would-be invaders. One such immune system is the CRISPR-Cas system, an adaptive immune system able to record the genetic signature of invading viruses in order to recognize and destroy them should they be encountered again in the future. In this thesis I present data that sheds light on the mechanism of one particular subtype of CRISPR-Cas systems: the type …

Investigating Stability Of Cone-Derived Hypersonic Waverider Vehicles Via Design Space Exploration, Adam S. Weaver

All Graduate Theses and Dissertations, Fall 2023 to Present

It may come as no surprise that man-made objects flying at 5, 10, or even 25 the speed of sound (termed hypersonic) are difficult to design, inefficient in flight, and expensive to deploy. Most hypersonic vehicles are effectuated in ballistics, which simplify aerodynamic considerations owing to their fixed trajectory. However, maneuverable hypersonic vehicles can revolutionize commercial flight, national defense, and space travel. One candidate for such missions are waverider vehicles. Waverider vehicles cruise on a cushion of air generated by its own shock wave, essentially enjoying extra lift without any extra drag penalties (which are usually inherent to extra …

Dynamics Of Rotating 2d Ellipse In Stratified Flow, Anton G. Kadomtsev

All Graduate Theses and Dissertations, Fall 2023 to Present

Submersible vehicles that move through seawater are subjected to a variety of effects. Seawater has a non-uniform density because of uneven heating and the tendency of dense saltwater to sink. This non-uniform density distribution induced by gravity is known as stratification and introduces vertical confinement and internal gravity waves to flows around bodies. Along with translational motion, these vehicles also perform rotational motion. To identify the effects of density gradient, body shape, and rotation on the flow, 2D direct numerical simulations (DNS) are run and analyzed. The simulations are conducted using the open-source CFD solver Nek5000, utilizing its overset-grid-based methodology. …

Quantification Of Blue Carbon Within The Marine Animal Forest On The Rio Grande Valley Artificial Reef, Michelle Kathryn King

Theses and Dissertations

The protection and enhancement of coastal ecosystems provides a number of benefits such as heightened biodiversity, increased fisheries, and enhanced carbon capture (Yeemin et al., 2024). The study of blue carbon ecosystems has expanded rapidly in the last two decades since the term was coined in 2009 (Lovelock & Duarte, 2019). The most well-known blue carbon ecosystems include vegetation-dominated ecosystems such as seagrass meadows, salt marshes, and mangrove forests (Howard et. al., 2014). Prior studies have overlooked Marine Animal Forests (MAF) ability to capture carbon, until recent studies on soft coral (Coppari et al., 2019) and sponge (Rix et al., …

A Modern Prometheus: Frankenstein's Relevance In Our Modern Society, Amanda C. Partida

Theses and Dissertations

For over two hundred years Mary Shelley’s Frankenstein has been in the public consciousness. It took only five years for the first adaptation, Presumption; or the Fate of Frankenstein, to be staged in 1825. Since then, there has been at least one adaptation every decade, with Universal Studios’ 1931 Frankenstein as the most famous adaptation, which shows just how much Shelley’s novel of science and hubris has resonated with audiences for many years.

This thesis aims to connect the ever-changing scientific anxieties of society with the most well-known Frankenstein film adaptations. By focusing on four specific films Frankenstein (1931), …

P-Adic Quantum Mechanics, Infinite Potential Wells, And Continuous-Time Quantum Walks, Nathaniel P. Mayes

Theses and Dissertations

In this thesis, we introduce a p-adic version of the infinite potential well in quantum mechanics (QM). This model describes the confinement of a particle in a p-adic ball. We rigorously solve the Cauchy problem for the Schrödinger equation and determine the stationary solutions. The p-adic balls are fractal objects. By dividing a p-adic ball into a finite number of sub-balls and using the wavefunctions of the infinite potential well, we construct a continuous-time quantum walk (CTQW) on a fully connected graph, where each vertex corresponds to a sub-ball in the partition of the original ball. …

Implementing And Evaluating An Ai-Powered Visual Decision Support System To Improve Antibiotic Usage Among Physicians With A Built-In Early Warning System, Akua Sekyiwaa Osei-Nkwantabisa

Theses and Dissertations

The widespread misuse and excessive prescription of antibiotics have played a pivotal role in the emergence and proliferation of antibiotic-resistant bacteria, posing a critical global public health crisis. Addressing this challenge necessitates innovative solutions that enhance antimicrobial stewardship. This study presents the development and implementation of a visual decision support system designed to monitor and optimize antibiotic usage among healthcare providers. The proposed system integrates advanced machine learning algorithms with real-time data analytics to provide a dynamic, evidence-based decision support tool. Specifically, a neural network model was developed after evaluating multiple machine learning approaches, including Random Forest, Logistic Regression and …

Camassa-Holm Type Equations And Multi-Peakon Solutions, Yonghong Chen

Theses and Dissertations

This thesis investigates the multi-peakon solutions of a class of Camassa-Holm type equations with quadratic nonlinearities, specifically focusing on the differential equation mt +θmu+ amxu+bmux = 0, where m = u−uxx, and θ, a, b are arbitrary constants. We derive the nonlocal form of the equation and explore its peakon dynamics, including the well-known Camassa–Holm, Degasperis–Procesi, and Holm–Staley b-family equations. By employing a practical computational approach, we analyze the N-peakon solutions and present the corresponding dynamical systems, particularly focusing on the two-peakon case. The results will …

Effectiveness Of Virtual Reality Rehabilitation For Cervical Spinal Cord Injury: A Systematic Review And Meta-Analysis, Viprav B. Raju, Brian D. Schmit, Aditya Vedantam

Biomedical Engineering Faculty Research and Publications

This systematic review and meta-analysis evaluated the effectiveness of virtual reality (VR) rehabilitation in improving functional performance for patients with cervical spinal cord injury (CSCI), which affects both upper and lower limb function. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, electronic databases including PubMed, Medline, Embase, Scopus, and Cochrane Library were searched. Meta-analysis was conducted on studies reporting common functional outcomes, with standardized mean difference (SMD) used to quantify effect sizes. Nine studies were included in the systematic review, and seven were analyzed in the meta-analysis. Three studies focused on upper limb outcomes, and six …

Automated Identification Of Clinically Meaningful Biomechanical Phenotypes In Cerebral Palsy Through Multicenter Gait Data, Adam Graf, Joseph Krzak, Karen M. Kruger, Jon Davids, Ryan Smith, Brandon Steinlein, Anita Bagley

Biomedical Engineering Faculty Research and Publications

Background

Cerebral palsy is the most prevalent motor disability in childhood, encompassing various movement disorders that affect walking. Researchers have described gait patterns in cerebral palsy, but these are often subjective and based on clinician experience. This study introduces an automated approach to objectively identify clinically meaningful biomechanical phenotypes in cerebral palsy and test it on multicenter gait data. Utilizing instrumented gait analysis, this research aims to improve treatment strategies for gait dysfunction. This study addresses whether classification algorithms can objectively identify clinically meaningful gait patterns and if severe gait deviations are more frequent in advanced forms of cerebral palsy. …

Locked Dimerized Cxcl12 Exerts Radiosensitizing Effects In Head And Neck Cancer, Oscar Villarreal Espinosa, Musaddiq Awan, Abdullah A. Memon, Anne Frei, Jamie Foeckler, Rachel Kuehn, Jennifer Bruening, Becky Massey, Stuart J. Wong, Monica Shukla, Julia Kasprzak, Amit Joshi, Michael B. Dwinell, Heather A. Himburg, Joseph Zenga

Biomedical Engineering Faculty Research and Publications

Background

Head and neck squamous cell carcinoma (HNSCC) presents significant treatment challenges, particularly in cases unrelated to human papillomavirus (HPV). The chemokine receptor CXCR4, interacting with its ligand CXCL12, plays a crucial role in tumor proliferation, metastasis, and treatment resistance. This study explores the therapeutic potential of engineered monomeric and dimerized CXCL12 variants (CXCL121 and CXCL122, respectively) in HNSCC and evaluates potential additive effects when combined with radiation therapy.

Methods

Clinical HNSCC biopsies were evaluated for CXCR4 expression in both previously untreated and radiorecurrent disease. HNSCC cell lines were then treated with combinations of CXCL12 variants and radiotherapy and interrogated …