Digital Commons Network^™

Mechanisms Of Protective Humoral Immunity And Pathogenesis In Alphavirus Infection, Natasha Monir Kafai

Arts & Sciences Graduate Student Theses and Dissertations

Alphaviruses are enveloped, mosquito-transmitted, positive-sense RNA viruses of the Togaviridae family classified into Old and New World groups based on endemic regions and human disease characteristics. Old World alphaviruses, including chikungunya virus preferentially cause arthritogenic disease, whereas New World viruses like Venezuelan equine encephalitis virus (VEEV), Eastern equine encephalitis virus (EEEV), and Western equine encephalitis virus (WEEV) can cause neurological disease. Since the 1920s, VEEV has been responsible for major periodic outbreaks affecting hundreds of thousands of humans and equines in South and Central America. Expansion of mosquito vectors raises concern for possible VEEV reemergence. In addition, VEEV is a …

Architecture Through Modularity, Jafet Estrada

Bachelor of Architecture Theses - 5th Year

Globally, an estimated 1.8 billion people lack access to adequate housing with an included 150 million people who live in permanent homelessness. Additionally, Housing costs have significantly outpaced income growth globally. Between 2014 and 2022, house price-to-income ratios have risen, with the global median ratio now at 6.1 (up from around 5 in 2014). Architecture through modularity could transform these lives with low-cost solutions. Modularity more broadly refers to a system’s ability to be broken down into smaller, self-contained, and interchangeable parts or modules. These modules function independently but are designed to work together as part of a cohesive whole. …

Interactive Bodies: Creating A Haptic Dialogue, Evan R. Haller

Bachelor of Architecture Theses - 5th Year

BUILDINGS ARE BORING. The majority of modern buildings often fail to have meaningful engagements with their occupants, resulting in static spaces that prioritize function over experience. If we continue to design for pure functionality, are we any different from machines? My thesis, “Interactive Bodies: Creating a Haptic Dialogue,” explores a shift in architectural design where spaces can adapt and change depending on the users’ ability to interact with them.

Through various case studies on kinetic architecture and interactive design experiments, as well as inspiration from Archigram, my research investigates how kinetic components can foster a more meaningful relationship between people …

Implementation Of Classroom Technology For Elementary Students With Adhd, Melanie Flemming

Walden Dissertations and Doctoral Studies

The problem addressed in this study is the teacher-reported increase in behavioral problems among students with attention-deficit hyperactivity disorder (ADHD) since a mandated introduction of educational technology in the classroom aimed at improving student performance. Using the PICRAT (passive, interactive, creative, replacement, amplification, transformation) describes the impact of technology on a teacher's previous practice model as the conceptual scaffold, this study was conducted to explore teachers’ experiences integrating educational technology and any corresponding student behavioral changes in classrooms that include students with ADHD. Following a basic qualitative design, data were collected through semistructured interviews, using a self-designed interview protocol, with …

Successful Strategies Utilized By Business Leaders To Balance Tax Planning With Profitability, Quarnelia Patterson

Walden Dissertations and Doctoral Studies

The absence of business tax planning strategies can lead to a higher tax burden. Business owners are concerned because a higher tax burden may result in lower after-tax earnings and reduced cash flow. Grounded in the PESTLE analysis framework, the purpose of this qualitative pragmatic inquiry study was to explore successful strategies that business leaders use to balance tax planning with profitability. The participants were eight small business owners located in the southwest United States who actively engaged in tax planning. Data were collected using semistructured interviews and a review of publicly available documents. Through thematic analysis, nine themes were …

Examining The Impact Of Reentry Programs On The Employability Of African American Ex-Offenders Entering The Workforce In The State Of Michigan, Lawrence Gene Caldwell

Walden Dissertations and Doctoral Studies

African American ex-offenders in Michigan have faced numerous challenges when trying to secure employment after incarceration. Despite the well-documented difficulties of reintegration, their personal experiences and perceptions of these obstacles remain largely unexplored. Successful reintegration has required individuals to break free from the behaviors and social patterns reinforced during their time in prisons. This generic qualitative study examined the role of reentry programs in addressing these challenges and emphasizes the need to reassess current criminal justice practices to better support formerly incarcerated individuals. This generic qualitative study focused on the employment struggles faced by African American ex-offenders and the broader …

Probation Officers Perceptions Of Probationers Economic Barriers To Successfully Complete Probation In Eastern North Carolina, Dwayne Ponton

Walden Dissertations and Doctoral Studies

This qualitative phenomenological study explored probation officers’ perceptions of the economic barriers that prevent probationers in Eastern North Carolina from successfully completing probation. Challenges such as unemployment, financial sanctions, housing instability, and debt were identified as key obstacles contributing to noncompliance and recidivism. Grounded in Merton’s Strain Theory, the study addressed a gap in research by focusing on the experiences of officers who directly supervise probationers facing economic hardship. Data was collected through semi-structured interviews with twelve officers and analyzed using thematic analysis. The study was guided by two research questions: (1) What economic barriers prevent probationers from successfully completing …

The Effectiveness Of Postincarceration Reentry Programming In Fostering Community Reintegration For Women, La Shawn B. Kelley

Walden Dissertations and Doctoral Studies

Identifying gaps in reentry programs for formerly incarcerated women is challenging due to the lack of evaluations that include the perspectives of the transitioning women on which components most effectively support their reintegration. The purpose of this generic qualitative study was to explore the experiences and perceptions of transitioning women who received reentry services, in order to assess program effectiveness in community reintegration and inform future interventions. The research question for this study was, how do women served by Organization A’s reentry program describe the program’s effectiveness in preparing them for community reintegration after incarceration? To answer the practice-focused research …

Mitigating Supply Chain Disruptions In The Retail Warehousing Industry, Terricka Nichole Townsend

Walden Dissertations and Doctoral Studies

Retail warehousing stability is increasingly threatened by global uncertainties and supply chain disruptions, requiring urgent and innovative strategies. This issue is critical for retail warehousing managers and supply chain leaders, as their ability to respond impacts organizational resilience, business continuity, and customer satisfaction. The purpose of this qualitative pragmatic inquiry was to explore strategies used by retail warehousing managers to mitigate the negative impacts of supply chain disruptions on business stability. The situational crisis communication theory and attribution theory provided the conceptual framework for understanding how retail warehousing managers communicate and respond to supply chain disruptions while maintaining stakeholder trust …

Rescue Of The First Mitochondrial Membrane Carrier, The Mpic, By Tat-Mediated Protein Replacement Treatment, Samar Zabit, Orly Melloul, Michal Lichtenstein, Erin L. Seifert, Haya Lorberboum-Galski

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The mitochondrial phosphate carrier (mPiC), encoded by the nuclear gene SLC25A3, is synthesized with an N-terminus mitochondrial targeting sequence (MTS), enabling its import into the mitochondria. mPiC imports inorganic phosphate (P_i) into the mitochondrial matrix for ATP production and other matrix phosphorylation reactions, as well as regulates mitochondrial Ca²⁺ uptake and buffering of matrix Ca²⁺. PiC also imports copper (Cu), crucial to COX subunit holoenzyme assembly. Variants in SLC25A3 exist and lead to mPiC deficiency (MPCD), cause a rare autosomal recessive disease with no current cure; patients with MPCD usually die within the first …

The Rising Returns To R&D: Ideas Are Not Getting Harder To Find, Yoshiki Ando, James Bessen, Xiupeng Wang

Faculty Scholarship

R&D investment has grown robustly, yet aggregate productivity growth has stagnated. Is this because “ideas are getting harder to find”? This paper uses micro-data from the US Census Bureau to explore the relationship between R&D and productivity in the manufacturing sector from 1976 to 2018. We find that both the elasticity of output (TFP) with respect to R&D and the marginal returns to R&D have risen sharply. Exploring factors affecting returns, we conclude that R&D obsolescence rates must have risen. Using a novel estimation approach, we find consistent evidence of sharply rising technological rivalry. These findings suggest that R&D has …

How Much Should Consumers With Mild To Moderate Hearing Loss Spend On Hearing Devices?, Vinaya Manchaiah, Steve Taddei, Abram Bailey, De Wet Swanepoel, Hansapani Rodrigo, Andrew Sabin

School of Mathematical & Statistical Sciences Faculty Publications

Background: This study examined the relationship between hearing device price and sound quality. Method: A novel consumer-centric metric of sound quality (“SoundScore”) was used to assess hearing devices’ audio performance. Each hearing device is tested with two fittings. The “Initial Fit” is designed to approximate the most likely fitting for an individual with a mild-to-moderate sloping sensorineural hearing loss. The “Tuned Fit” includes adjusting parameters optimized to hit prescriptive fitting targets (NAL NL2) on an acoustic manikin. Each fitting is evaluated across five dimensions. Both fittings are combined using a weighted average to create a single number from 0 to …

Mohamed Osman Abdelgader Mariam Hamid, And Dina Luka, As Personal Representative Of The Estate Of Ahmed Abdelgader, Plaintiffs And Appellants V. Utah Department Of Transportation, Apolitical Subdivision Of The State Of Utah; And Does 1 Through 20, Inclusive Defendants And Appellees : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the Third Judicial District Court, Salt Lake County, District Court, Case No. 200906404, Honorable Amber M. Mettler presiding.

Peggy E. Stone, Attorney for Defendant and Appellee

Catecholaminergic Polymorphic Ventricular Tachycardia-Linked Ryanodine Receptor Variants Exhibit Domain-Specific Calcium Leak And Calmodulin Affinity Properties, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H T Wehrens, Takeshi Yamamoto, Razvan L Cornea, Robyn T Rebbeck, Masafumi Yano, Donald M Bers

Faculty, Staff and Students Publications

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited stress-induced arrhythmogenic disease often caused by point variants in the cardiac ryanodine receptor (RyR2) that enhance diastolic sarcoplasmic reticulum (SR) Ca2+ leak. These RyR2 variants cluster in three hot-spots (N-terminal, central and C-terminal domains). We previously demonstrated a pathologic diastolic RyR2 conformation in heart failure, oxidative stress and CaMKII phosphorylation exhibiting a trilogy of effects: (1) reduced calmodulin (CaM)-RyR2 affinity, (2) enhanced unzipping peptide (DPc10) binding and (3) elevated diastolic SR Ca2+ leak that are dantrolene-sensitive. Here we test whether this pathological trilogy occurs in CPVT knock-in (KI) mice bearing N-terminal (R176Q/+), …

Aggn: Adaptive Granularity Graph Networks For Heterophilic Environments

Defensive Publications Series

Graph neural networks (GNNs) have shown significant success in learning graph representations. However, recent studies reveal that GNNs often fail to outperform simple MLPs on heterophilous graph tasks, where connected nodes may differ in features or labels, challenging the homophily assumption. Existing methods addressing this issue often overlook the importance of information granularity and rarely consider implicit relationships between distant nodes. To overcome these limitations, we propose the Adaptive Granularity Graph Network (AGGN), a novel GNN model specifically designed for heterophilous graphs. AGGN enhances node embeddings by aggregating multi-view information at various granularity levels and incorporating implicit data from distant, …

Halo: Heterophily-Aware Label-Free Ordering For Unsupervised Graph Fraud Detection

Defensive Publications Series

Graph fraud detection (GFD) has rapidly advanced in protecting online services by identifying malicious fraudsters. Recent supervised GFD research highlights that heterophilic connections between fraudsters and users can greatly impact detection performance, since fraudsters tend to camouflage themselves by building more connections to benign users. Despite the promising performance of supervised GFD methods, the reliance on labels limits their applications to unsupervised scenarios; Additionally, accurately capturing complex and diverse heterophily patterns without labels poses a further challenge. To fill the gap, we propose a Heterophily-guided Unsupervised Graph fraud dEtection approach (HUGE) for unsupervised GFD, which contains two essential components: a …

Learning Resilient Graph Structures In Heterophilic Settings

Defensive Publications Series

Graphs provide a fundamental way to model relationships between entities and are central to numerous machine learning tasks. Standard graph-based methods often assume the provided graph structure is both accurate and complete. However, real-world graphs frequently suffer from noise and sparsity, negatively impacting downstream tasks like node classification and clustering. While graph representation learning has advanced significantly, many methods implicitly assume graph homophily (connections predominantly between nodes of the same class), struggling when faced with heterophily (connections predominantly between different classes). This paper introduces a novel method, Resilient Graph Learning for Heterophily (RGLH), designed to learn high-quality graph structures directly …

Quantum-Coherent Graphene Via Entangled Plasma Deposition (Coherium™) Room Temp Superconductor, Peter Branton

Defensive Publications Series

Twisted bilayer graphene (TBG) at a magic angle (~1.1°) has demonstrated superconductivity below ~1.7 K due to emergent flat-band behaviour. However, its mechanical assembly limitations, thermal fragility, and scalability issues hinder real-world applications. The Coherium™ process addresses these limitations by synthesizing entangled carbon plasma into a structurally coherent graphene lattice with integrated AI stabilization, targeting room-temperature Superconducting properties.

Efficient Partitioning For Devices With Multiple User Modes, Harshad Dhabu, Abhijit Adsule

Defensive Publications Series

This document describes techniques that enable a computing device (e.g., a smart watch, ring, glasses, etc.) to more efficiently transition between multiple user modes, such as an adult mode and a child mode. Using a single system image including applications installed on the computing device for every user mode may lead to system image bloat, diminished performance and power inefficiency. Alternatively, creating separate stock keeping units (SKUs) for each user mode may introduce manufacturing and inventory complexities. Instead, the device may divide the device's storage and the applications corresponding to each user mode into three partitions. The first partition may …

Machine Learning System And Method For Predicting Risk Of Drilling Component Failure, Baker Hughes Company

Defensive Publications Series

The invention addresses the problem of drilling tool failure risk assessment in the oil and gas industry. Tool failure in drilling operations can lead to significant financial losses, downtime, and safety risks. The invention aims to provide a solution for predicting and preventing these failures, which is crucial for maintaining safe and efficient drilling operations.

The invention proposes a solution by combining data-driven techniques with expert knowledge. It begins with data collection, including historical data on tool performance, and involves data cleaning and pre-processing. Relevant features are identified, and a predictive model is developed using machine learning techniques. The model …

Quantum Smart Entangled Fusion Reactor, Peter Branton

Defensive Publications Series

The invention relates to a compact, high-efficiency energy generation system employing

quantum-entangled hydrogen isotope fusion within nanoscale confinement structures. It

comprises a multiplicity of individually controlled fusion traps formed at nanometer scale, each

configured to receive pre-entangled pairs of hydrogen isotopes such as protium, deuterium, or

tritium. Each trap is stimulated by attosecond-timed electromagnetic resonance pulses to induce

fusion via quantum tunneling. Fusion events are monitored and optimised through an integrated

artificial intelligence (AI) control layer that ensures only coherence-validated, phase-aligned

pairs are activated. The system includes capacitive and inductive energy reclamation

components, and operates in inert gas environments without …

Volume 7 Complete Issue, James W. Gallagher

The Geographical Bulletin

Volume 7 Complete Issue

City Structure And City Change: A System Analysis Approach, A. Y. Abu-Ayyash

The Geographical Bulletin

The structure of the city and the transformation processes which generate changes in its structure have fascinated intellectuals from many disciplines. Sociologists are mainly concerned with the social structure and the demographic characteristics of the inhabitants of the city as a base for understanding its structure. Economists are concerned with economic forces in terms of locational competition as the main reasons for the changing structure of the city. Engineers are concerned with the architecture of the city.

Enhancing Advanced Practice Nursing: Implementing A Simulation-Based Point-Of-Care Ultrasound Training Program, Brandy Younge, John Chovan, Bonnie Fagan, Joy Shoemaker

Doctor of Nursing Practice Scholarly Projects

Nurse practitioners (NPs) are advanced practice nurses entrusted with diagnosing and treating illnesses, managing acute and chronic diseases, and engaging in continuous education to remain knowledgeable of evidence-based advancements. NPs offer a comprehensive range of healthcare services, catering to patients from wellness check-ups to those requiring complex care, such as individuals hospitalized with sepsis. One technological advancement that can support NPs in delivering optimal patient care is point-of-care ultrasound (POCUS). In the United States, over 385,000 NPs practice in patient care settings that may use POCUS. Numerous medical societies have issued position statements supporting the use of POCUS in the …

Birds Of A Feather: An Integrated Outdoor-Based Bird Study P-3 Curriculum Guide, Erin A. Buzza

Masters Theses/Capstone Projects

In a post-pandemic world that places technology at the at the forefront, educators are searching for ways to help students connect with the natural world. This project aids teachers in tackling this challenge by using the study of birds as a motivation to engage students with the outdoors and local wildlife. To demonstrate how ornithology topics can be used as an integrated thematic unit, research regarding components of ecological literacy is presented. They include nature-based learning, outdoor learning, environmental education, and wildlife education. In addition to these pedagogies, the benefits of incorporating interdisciplinary learning within the classroom are also provided …

Final Scholarly Project: The Administration Of Transversus Abdominis Plane Blocks In Patients Undergoing Anesthesia For Open Ventral Hernia Repairs, Brennon Pinion

Doctor of Nursing Practice Scholarly Projects

Ventral hernia repairs are the only definitive treatment for umbilical or abdominal hernias. These procedures are prevalent and often lifesaving but also carry high risks of adverse effects. Some of the problems that follow include postoperative ileus, increased opioid use, and prolonged length of stay. Due to the rate of complications, there was a need to improve these outcomes. One way to improve outcomes is to implement superior anesthetic techniques. This Final Scholarly Project (FSP) followed the Plan-Do-Study-Act (PDSA) model to conduct evidence-based practice (EBP) and quality improvement (QI) sections. The plan phase included a thorough literature search and analysis …

Implementation Of Guidelines For Preprocedural Ultrasound In Neuraxial Placement For Obstetric Patients With Scoliosis, Luther Nyirenda

Doctor of Nursing Practice Scholarly Projects

Neuraxial anesthesia including epidural, spinal, and combined spinal-epidural, is used with 65% of parturients in the United States for the management of pain and discomfort. Conventional landmark palpation has been the mainstay technique for neuraxial anesthesia, but unfamiliar spinal anatomy can lead to incomplete blockade or an increased incidence of complications. Scoliosis causes lateral curvature and rotation of the spine leading to arthritis and soft tissue changes that can present obscure anatomical landmarks, cause difficulty in needle passage, and result in inadequacy of local anesthetic efficacy. The literature illustrates that preprocedural ultrasound is recommended for needle placement in parturients with …

Data Advantage And Merger Review: Can Entrenchment Theory Reform Antitrust Enforcement?, Shin-Ru Cheng

Seattle University Law Review

A merger involving giant digital companies is likely to dampen competition, as it allows those companies to combine and control data access, enabling them to entrench their dominant positions in relevant markets and extend those positions into related markets. While competition law in many jurisdictions aims to prohibit mergers that may substantially lessen competition or create a monopoly, arguably the review of digital mergers is failing because antitrust agencies lack an effective approach to identify data-generated anticompetitive harms. This Article demonstrates that entrenchment theory, recently reintroduced in the 2023 U.S. Merger Guidelines, would help reform the process of antitrust enforcement. …

Subjective Evaluation Of Place Environmental Quality In Conference And Exhibition Buildings In Small- And Medium-Sized Cities: An Empirical Case Study, Yuchen Xie, Jianhe Luo, Peng Du

College of Architecture and the Built Environment Faculty Papers

The environmental quality of conference and exhibition places in small- and medium-sized cities plays a crucial role in attracting exhibitors, fostering the growth of the conference and exhibition industry and enhancing the market competitiveness of these places. However, past decision makers have often adopted planning models from large cities, neglecting the interaction between conference and exhibition places in smaller cities and local lifestyles as well as urban environments. From an “environment-behavior” per- spective, this study reveals the unique interaction mechanisms between exhibitors and the built environment within such venues. Moving beyond the limitations of traditional research that focused solely on …

Globelly: The Travel App, Diana S. Alvarez

Honors Capstones

My honors capstone project, Globelly: The Travel App, began as a feature-rich Android application designed to simplify travel planning, enhance global exploration, and foster community-driven sharing among travelers. The app was envisioned to integrate real-time suggestions using APIs like Yelp and TripAdvisor, incorporate a badge-based gamification system, and support advanced customization and privacy controls. While not all of these features were implemented in the final version, the project achieved a solid and functional foundation focused on core travel-sharing experiences.

Developed using Java, XML, and the MVC architecture in Android Studio, the completed app allows users to pin locations they’ve …