Digital Commons Network^™

A Sumo-Interacting Motif In The Guanine Nucleotide Exchange Factor Epac1 Is Required For Subcellular Targeting And Function, Wenli Yang, Fang Mei, Wei Lin, Jason E Lee, Si Nie, Christopher J Bley, André Hoelz, Xiaodong Cheng

The Brown Foundation: Institute of Molecular Medicine

Exchange protein directly activated by cAMP (EPAC1), a multifunctional intracellular cAMP receptor, dynamically localizes to various cellular loci, engaging with diverse molecular partners to maintain cellular homeostasis. The study investigates the role of the SUMO-interacting motif (SIM) in the subcellular targeting and cellular functions of EPAC1. It reveals that the SIM is a critical structural element for EPAC1's association with RanBP2/nucleoporin 358, a nucleoporin of the cytoplasmic filament component of the nuclear pore complex. Mutational disruption of EPAC1 SIM interferes with EPAC1's ability to activate its canonical effectors, small GTPases, Rap1 and Rap2, and noncanonical functions, such as the formation …

Hybrid Renewable Energy Systems Towards Sustainable Development In Bangladesh: Configurations, Optimizations, Applications, Challenges And Future Pathways, Zia Ul Islam, M.S. Hossain Lipu, Abu M. Fuad, Tuhibur Rahman, Md Ashraful Islam, Mahidur R. Sarker

Artículos científicos

Renewable energy has gained significant popularity in Bangladesh due to its potential to provide a sustainable and reliable future while reducing dependence on fossil fuels and lowering greenhouse gas emissions. However, despite these advantages, renewable energy sources face challenges, particularly regarding intermittency and variability, which can impact the stability and reliability of the power supply. To address these challenges, hybrid renewable energy systems offer a potential solution to the energy crisis in Bangladesh by integrating multiple renewable energy sources, thereby enhancing overall reliability and efficiency while mitigating the limitations of individual sources. In this context, this review critically examines various …

Graduate School Blog - June 2025, Cynthia Haynes

UofM Grad School Blog

The June 2025 edition of the UofM Graduate School Blog helps prospective and current students make informed financial decisions with Part 1 of the Graduate School Cost Guide, breaking down tuition structures such as per-credit hour versus flat-rate models, highlighting UofM’s tuition cap for in-state students, and explaining key university fees and cost differences between online and on-campus formats. The blog also features Brianna Reilly, a Doctor of Musical Arts graduate from New York, who shares how a graduate assistantship and her passion for music education led her to continue at UofM through the pandemic. Additional resources include an …

How Gaza Sees The 2023-2025 War And The Future Of The Israel-Palestine Conflict, Scott Atran, Laura Rodriguez-Gómez, Kamil Yilmaz, Ángel Gómez

New England Journal of Public Policy

In political science and international relations, as in foreign policy and military circles, a debate is ongoing between “realists” and “moralists” regarding the importance of material factors (territory, economy, security, etc.) versus value-laden factors (justice, ideals, identity, etc.) in motivating, sustaining, and ending wars. An early 2025 representative survey of Gaza’s population considers both sets of factors in how Gazans perceive the present and future states of the Israel-Palestine conflict. Comparisons with our previous studies in the Middle East, North Africa, and Europe aim to extend this survey’s relevance beyond the current Israel-Palestine theater. The survey suggests that after waging …

The Day You Begin: A Case Study Of Culturally Responsive Pedagogy In Early Childhood Classrooms, Kim Shelton

Dissertations

Culturally responsive pedagogy (CRP) has garnered growing attention in early childhood education due to its potential to cultivate inclusive and equitable learning environments for increasingly diverse student populations. This qualitative case study examines how early childhood educators perceive and implement CRP in classrooms with high concentrations of immigrant and culturally diverse students. Additionally, it explores the perceived impact of these practices on instructional effectiveness, classroom climate, and teacher-student interactions.

Data was collected through semi-structured interviews, classroom observations, and document analysis. Thematic analysis yielded four central findings: (1) teachers’ understandings of CRP varied considerably, with some demonstrating strong intentionality and others …

Power Transmission System Demo, Jeremy Aiken, Shannon Robinson, Graham Dzengelewski

Mechanical Engineering

Professor Ramanan Sritharan and ME 329 students need a high-quality Power Transmission System, a detailed report, and robust Excel spreadsheet including all calculations that can serve as an example for students in the ME 329 lab.

Foot Pedal Assistive Device, Julian Rubinstein, Connor Jessen, Isabelle Utsler, Sydney Alexander

Mechanical Engineering

Individuals with lower-limb mobility problems may have trouble accurately locating the pedals of a three-pedal manual transmission car, and some medical conditions cause individuals to fatigue more quickly when driving. This project aimed to create a device that assists in locating the user’s feet, indicates to the user which pedals are currently in use, and provides a visual and physical warning if they are not in the correct place. The project sponsor, Alan Keizer, is the primary stakeholder in this project. This device will be designed specifically for Alan’s Subaru BRZ and will address Alan’s specific lower-limb mobility issues that …

Van Accessibility, Ann Larson, Camelia Anne Noureddine, Stephanie Rose Ruzicka, Kayla Joanne Gowey

Mechanical Engineering

The SLO Achievement House provides resources and activities for their clients, including daily trips to different parts of the community, to keep their clients connected to society. These trips require the clients, many of whom struggle with general mobility and strength, to step up to the high entrance of a van or company car. This daily activity poses a challenge both physically and emotionally for the clients. The current solution utilizes commercially available step stools, which lack handrails, overall stability, and adequate step depth. The Achievement House needs a stool or ramp tailored to their client’s needs and their specific …

7lr-C Upper Limb Dancing Prosthetic, Victor Ochoa, Zoe Kelemen, Ged Mulingtapang, Marley Paltiel

Mechanical Engineering

Ella Wallis, a student at Cal Poly and performer in the Cal Poly Drag Club with a trans humeral upper limb difference, wants a prosthetic device that allows for a large range of motion and high degree of articulation to help them better dance in the style of voguing, allowing them to express themselves further while performing. The prosthetic arm is body-driven and relies on momentum to reposition. It attaches to the user through a harness, which is clipped to a socket with elastic straps to not impede the shoulder’s range of motion. The design contains urethane resin, aluminum, stainless …

Drone Package Delivery System, Aiden Tyler Sim, Ryan Anders O'Toole, Matthew Karl Wyant, James Shaw Glanville

Mechanical Engineering

In response to the demands of the 2025 C-UASC (California Unmanned Aerial Systems Competition), our team developed an autonomous drone payload delivery system capable of two distinct delivery modes: a precision-controlled descent and a high-speed aerial drop. Designed for modular integration with UAV platforms, the system prioritizes reliability, accuracy, and simplicity under desert environmental conditions. Our solution features a custom winch mechanism with a programmable stepper motor, a passive mechanical hook for tension-based release, and a servo-actuated trapdoor for high-altitude drops. The design was extensively tested for structural integrity, motor torque requirements, drop precision, and electronics reliability—culminating in a robust …

Uav & Ugv Drone Competition (Raytheon), Christian Michael Freese, Adien Edmond Haro, Ethan Ray Andres, Sam Sakaguchi

Mechanical Engineering

Autonomous vehicles have been starting to address real-world issues through innovative technology. RTX (Raytheon) needs a way to have two autonomous vehicles, an unmanned air vehicle (UAV), and unmanned ground vehicle (UGV) reliably communicate with each other with the goal of landing and delivering a payload to designated delivery zones. This will foster creativity, innovation, and team-solving skills. Additionally, it will also promote & strengthen university relationships, evaluate top graduates, and promote corporate branding.

This report details the design process of a UAV-UGV delivery system developed for the RTX Autonomous Vehicle Competition (AVC). The system features a custom-built hexacopter UAV …

Llnl Raft Flash Pole Redesign, Jack Stangel, Evan Wolfson, Jake Borden, Alexander Meeter

Mechanical Engineering

During research exercises in the ocean, Lawrence Livermore deploys a fleet of rafts outfitted with flash modules affixed to tall poles (in tandem called flash poles) that flash while a photo is taken to act as datums for data collection. The current flash pole design that the LIDSS (Lawrence Livermore Independent Diagnostic Scoring System) team uses is too short to be visible in high seas, not mechanically suited to be made taller, too susceptible to the elements and blunt impact and too difficult to service. We aim to solve these issues.

Torsional Vibration Kit Simulator (Tks), Joseph Thachet, Luca Lawson, Ryan Ota, Otis Mcloughlin

Mechanical Engineering

The goal of this project was to create torsional vibration on a shaft while limiting axial and radial vibration. To do this an eddy current brake was used to slow down a rotating shaft. The electromagnets used to create the eddy currents are able to be turned on and off at a frequency produced by a function generator. This power cycling of the electromagnets creates an alternating braking force thereby inducing torsional vibration while limiting the other two vibration types

Uv Vessel Hoist Scope Of Work, Quinn J. Horak, Harvey Perkins, Andrew A. Osborn, Mikayla H. Nieman

Mechanical Engineering

The San Luis Obispo Wastewater Treatment Plant uses ultraviolet (UV) tubes to purify water. These tubes are cleaned by an internal wiping mechanism that must be removed for servicing and replacing damaged tubes. Currently, this is accomplished by using an engine hoist, but this method requires a large amount of effort and is not safe. Technicians have requested a new method of lifting wiper mechanisms that is safer, faster, and easier to use than their current method.

To solve this problem, we have developed a design that consists of a custom gantry crane with a hoist on a trolley. The …

Trailer Transport System For Multi-Ton Bins, Joanna Lizbeth Bendy, Kevin Matthew Creel, Annelise Vaara Cuneo, Hugo Alonso Valdez

Mechanical Engineering

This project aimed to improve the process of transporting 10,000-pound industrial waste bins. The current method for relocating these bins poses safety risks and requires significant manual effort. This project presents a conceptual solution that enables a single operator to efficiently and safely move roll-off bins using a custom-designed trailer system. The design incorporates three main subsystems: a trailer frame, an integrated winch system, and an off-the-market puller device to guide and secure the bin during transport. Two scaled proof-of-concept prototypes were fabricated to evaluate key aspects of the system's functionality. Testing and analysis suggested that the system is viable …

Brush Seal Cycling Test Rig, Angelo J. Reis, Neil M. Bedagkar, Max A. Soury, Eoin K. Lenham

Mechanical Engineering

To prevent backflow from the high pressure compressor stages of their gas turbines to lower pressure regions, Solar Turbines utilizes brush seals along their driveshafts. Due to manufacturing limitations, no shaft is perfectly symmetric about its rotating axis, leading to orbiting that creates asymmetric friction on the shaft through rubbing. With this biased application of friction comes a hotspot on one side of the shaft, causing bowing of the shaft and cascading into an amplified vibrational response. Our goal is to gather data on this phenomenon and offer a potential solution.

Heart Valve Leaflet Cutting Automation, Gabriella Aclan, Josh Deweese, Lizzie Dilao, Jason Wong

Mechanical Engineering

The content contained in this report is confidential and proprietary information of Edwards Lifesciences.

Poly Mars Mini-Rover, Dane Carroll, Aaron Lubinsky, Henry Bouma, Gerardo Tapia-Onate, Scott Frizzel

Mechanical Engineering

The Cal Poly Mars Rover project is creating a fleet of near-identical rovers operating collaboratively to research the surface of Mars. Over the last six years, teams at Cal Poly have been developing vehicles to be launched upon the commercialization of interplanetary travel. Two of these vehicles are to take the roles of ‘Scout’ and ‘Relay’ with the most significant difference being their respective ‘arms.’ The ‘Scout’ will have a robotic arm that interacts with objects on the surface while the ‘Relay’ will have a fixed arm, equipped with a StarLink antenna to communicate with orbiting satellites as seen in …

Air To Water Capture In Support Of Un Sustainable Development Goals, Jordan Macconnell, Michael Tiscareño, Ari Dennis, Baxter Mercy

Mechanical Engineering

This senior project explored the use of thermoelectric cooling for atmospheric water capture. The system was designed to cool aluminum condensing surfaces below the dew point using Peltier modules, with forced convection heat sinks on the hot side. The purpose of this system was to gather reliable amounts of water for various water-scarce areas around the world to help meet the UN's sixth Sustainable Development Goal.

The final design of this project consisted of a 1.5 x 1.5 x 2 foot frame made of acrylic panels and insulation. Within the frame, the thermoelectric system was constructed using Peltier modules with …

One-Handed Wheelchair, Brian Azevedo, Cade Veljovich, Carlos Perez, Jakob Zuckermandel, Alexander Harper

Mechanical Engineering

A person who uses a wheelchair for mobility needs a way to operate it with only one hand. This may be necessary if they lack functionality in one hand or prefer to use only one hand while operating the wheelchair. Even for users with two available hands, it is difficult to operate As of now, such wheelchairs are not widely available or easily accessible, yet these devices are crucial for improving the quality of life and mobility of many people. The goal of this project is to design a more viable and ergonomic solution for people who operate a wheelchair …

Micro Mobile Home R3, Roha Y. Ali, Yuka M. Iwashita, Luke C. Douglas, Joshua Q. Le

Mechanical Engineering

Homelessness is an ever-growing issue all around the world. In 2023, over 250,000 or ~40% of all people experiencing homelessness did not have access to shelter spaces in the U.S. [1]. All people have the right to a place where they are safe from violence, crime, and the constant fear that they will be forced out.

Both homeless people and outdoor enthusiasts need a new way to keep themselves and their belongings safe when living outdoors, since existing products do not offer adequate security, portability, or versatility.

2024-2025 Cal Poly Fluid Power Vehicle Competition Team, Jaskaran Singh Hothi, Justin Menzie Lesko, Tristan Kai Crawford, Lucas Rupert Erickson, Diego Velazquez

Mechanical Engineering

The Fluid Power Vehicle Challenge (FPVC) provides an avenue for the exploration of fluid-powered transportation, adhering to regulations set by the National Fluid Power Association (NFPA). This document serves as a roadmap for our team’s research, design, and manufacturing of a vehicle for participation in the FPVC. The team’s journey began with extensive background research, encompassing stakeholder engagement, analysis of existing solutions, and education on fluid power fundamentals. From this information, we decided to focus on enhancing mechatronics systems, improving the transmission, optimizing the mounting, adding a pneumatic element, and improving the efficiency of the hydraulic system of the vehicle …

Shop Skills, Colin Moore, Bridget Davenport, Xavier Gagnaire, Joseph Watanabe

Mechanical Engineering

The first goal of this project is to present the machine shops with a new and memorable Red Tag, recently rebranded as the License to Drill certification. This certification provides students with a lasting project that also teaches them about the usage and safety of a broader scope of machines.

After students receive their License to Drill, students must devote a minimum of two hours in the shop to gain access to further training associated with the lathes, mills, and welders. These trainings are now called Intermediate Shop Skills Trainings, formerly known as Yellow Tag Trainings. Our second goal is …

Large Backflow Check Valve Life Cycle Test Stand, Colin Bentley, Christopher Carloni, Ethan Gray, Luke Romanini

Mechanical Engineering

Backflow preventers are plumbing devices containing internal check valves used to prevent cross-contamination between downstream contaminants and potable water supply. Zurn Wilkins needs a life cycle test stand to mechanically force open check valves submerged in contaminated water and verify check performance. The stand needs to be modular to work with a range of check types and sizes.

Zurn Wilkins is the primary stakeholder for this project. Secondary stakeholders include commercial and residential building owners, contractors, and water utility companies, who rely on their products for safe and efficient water management. The team for this project consists of four Cal …

Hi-Trac Camera Jig, Gabriel Frank Junge, Josh Sherreitt, Jake Weiser, Luke Silver

Mechanical Engineering

Uranium fuel assemblies are stored upright in an underwater container inside the spent nuclear energy fuel pool at Diablo Canyon. The engineers and in-service-inspection team all work together to safely locate this container inside the pool on pins so it is guaranteed safe before they begin loading it with spent uranium fuel rods. The Operators currently employ the use of a zip-tied camera jig that is lowered into the pool along with the tank (called a HI-TRAC) to ensure it is oriented correctly in the pool. This camera jig is in desperate need of re-vamping and re-designing to optimize efficiency …

Expeditionary Ocean Power Generator, Otto Jacob Van Willigen, David Scott Nyberg, Logan Christopher Schilling, Kyle James Hohman, Travis Michael Eccher

Mechanical Engineering

The Expeditionary Ocean Power Generator (ExOPG) project is a point absorber wave energy converter developed by a team of five mechanical engineering seniors at California Polytechnic State University in partnership with NAVFAC EXWC. Designed to support U.S. Marine Corps operations, the device aims to reduce the reliance on diesel generators by generating and storing up to 100 watts of power from ocean waves in a sturdy and self-sufficient device.

The ExOPG device uses a rack and pinion mechanism driven by vertical wave motion to convert mechanical energy into electrical energy via a generator, which is then processed and stored by …

Bridging Worlds, Singapore Management University

Asian Management Insights

How philosophy, culture, and ethics shape leadership and learning.

Local Insights Into Global Value Chains, Pao-Li Chang

Asian Management Insights

Leveraging firm-level data to inform anticipatory economic policy decisions.

Evaluation Of Damages And Economic Losses In Light-Frame Timber Houses, Mason P. Leonard

Master's Theses

This thesis aims to evaluate the damages and economic losses in light-frame timber houses by designing and constructing a two-story, full-scale, fully equipped, code conforming timber assembly. Specifically, the structure will be analyzed based on how the non-structural components (NSC) like gypsum wallboard, interior doors, windows, and sliding patio doors as well as structural components like light-frame timber shear walls impact the economic losses.

Damage limit states were obtained from the Federal Emergency Management Agency (FEMA) P-58, Performance Assessment of Buildings to extract at what inter-story drift (ISD) ratio each damage limit state was expected to occur at. Fragility and …

Single-Sideband Pulse Width Modulation For Parametric Acoustic Arrays, Douglas Liu

Master's Theses

Parametric acoustic arrays are directional loudspeakers that operate using ultrasonic carriers to project sound within a narrow beam. Input audio is first modulated onto an ultrasonic carrier and transmitted through air, where it self-demodulates into audible frequencies in the far field.

This thesis introduces a method for preprocessing audio into scaled quadrature signals using a passive analog polyphase filter. These signals are modulated using microcontroller-generated waveforms to create quadrature ultrasonic pulse-width modulation (PWM) signals. The modulated outputs are combined through a wired-OR summer, producing single-sideband ultrasonic content at the desired frequency of 40 kHz. This signal is amplified through high-efficiency …