Digital Commons Network^™

Soybean Embryogenic Cell Culture Genetically Engineered, Gabriel Carrasquillo

Tennessee State University Alumni Theses and Dissertations

The inflation of population in the world has led to a high and consistent food demand which has reinvigorated worldwide interest to create high-yielding varieties of legumes. Soybean Glycine max (L.) Merrill, a member of this legume family has become one of the most essential food crops in the United States as well as in the world due its edible oil and protein content up to 20% and 54%, respectively. Because of its high importance as a food crop, major objectives in soybean breeding, improvement of protein and oil production need to be achieved. These objectives can be addressed using …

Investigating The Obstacles Of K-12 Saudi Teachers In The Use Of Educational ‎Technology ‎, Mohammed Albaqami

Tennessee State University Alumni Theses and Dissertations

The purpose of this study was to investigate the obstacles that K-12 teachers in general education schools in the Kingdom of Saudi Arabia face when implementing technology into their classrooms. This study was conducted within the city of Riyadh, Saudi Arabia. The purpose of the current study is to identify the degree of use of educational technology by teachers in K-12 schools, in addition to investigating teachers' perceptions about the obstacles using educational technology in K-12 schools in relation to the teachers, administration, and technology. The questions of this study were, therefore, “What is the degree of use of educational …

Navigating Sorghum Bicolor Microspores For Genetic Transformation Via Androgenic Pathway During Gametogenesis, Aron M. Felts

Tennessee State University Alumni Theses and Dissertations

This study delves into the use of the androgenesis pathway of microspores for genetic transformation and double haploid production in Sorghum bicolor. Focusing on the environmental and genetic factors that affect androgenesis, in vitro culture techniques were aimed to be refined for utilizing microspores towards callus induction more effectively. These efforts yielded promising approaches for agronomic traits enhancements. This research enhances the methodology for plant regeneration from microspores, facilitating the generation of homozygous lines with potentially improved traits. Although the current findings do not mark a radical departure from existing knowledge, they lay essential groundwork for future genetic studies in …

Ethical Leadership Of Universities Concerning Outreach Efforts During Covid-19, Sandra Bogard

Tennessee State University Alumni Theses and Dissertations

Navigating the COVID-19 pandemic proved challenging for Institutions of Higher Education. This study investigated the responses of higher education leadership to the pandemic as it related to their outreach efforts to assist their local community and healthcare system. The crisis leadership theory directed this research, focusing on the importance of leadership roles within institutions of higher education and how they responded to a crisis. This research concentrated on university leadership and whether they felt ethically obligated to assist their community during the pandemic, how they assisted, and whether they perceived their assistance as imperative for the community to overcome the …

Investigating The Obstacles Of K-12 Saudi Teachers In The Use Of Educational ‎Technology ‎, Mohammed Albaqami

Tennessee State University Alumni Theses and Dissertations

The purpose of this study was to investigate the obstacles that K-12 teachers in general education schools in the Kingdom of Saudi Arabia face when implementing technology into their classrooms. This study was conducted within the city of Riyadh, Saudi Arabia. The purpose of the current study is to identify the degree of use of educational technology by teachers in K-12 schools, in addition to investigating teachers' perceptions about the obstacles using educational technology in K-12 schools in relation to the teachers, administration, and technology. The questions of this study were, therefore, “What is the degree of use of educational …

Multicenter Validation Of A Machine Learning Model For Surgical Transfusion Risk At 45 Us Hospitals, Sunny S Lou, Sayantan Kumar, Charles W Goss, Michael S Avidan, Sachin Kheterpal, Thomas Kannampallil, Multicenter Perioperative Outcomes Group

2020-Current year OA Pubs

IMPORTANCE: Accurate estimation of surgical transfusion risk is important for perioperative planning and effective resource allocation. Most machine learning models in health care are not validated or perform poorly in external settings.

OBJECTIVE: To externally validate a publicly available machine learning algorithm (Surgical Personalized Anticipation of Transfusion Hazard [S-PATH]) to estimate red cell transfusion during surgery within a national sample of hospitals.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study evaluated all surgical cases performed in 2020 or 2021 at 45 US hospitals participating in the Multicenter Perioperative Outcomes Group. Obstetric and nonoperative cases were excluded. Data analysis was performed …

Deriving A Mammogram-Based Risk Score From Screening Digital Breast Tomosynthesis For 5-Year Breast Cancer Risk Prediction, Shu Jiang, Debbie L Bennett, Graham A Colditz

2020-Current year OA Pubs

Screening digital breast tomosynthesis (DBT) aims to identify breast cancer early when treatment is most effective, leading to reduced mortality. In addition to early detection, the information contained within DBT images may also inform subsequent risk stratification and guide risk-reducing management. Using transfer learning, we refined a model in the Joanne Knight Breast Health Cohort at Washington University, a cohort of 5,066 women with DBT screening (mean age, 54.6), among whom 105 were diagnosed with breast cancer (26 ductal carcinoma in situ). We applied the model to external data from the Emory Breast Imaging Dataset, a cohort of 7,017 women …

Validation Of A Dynamic Risk Prediction Model Incorporating Prior Mammograms In A Diverse Population, Shu Jiang, Debbie L Bennett, Graham A Colditz

2020-Current year OA Pubs

IMPORTANCE: For breast cancer risk prediction to be clinically useful, it must be accurate and applicable to diverse groups of women across multiple settings.

OBJECTIVE: To examine whether a dynamic risk prediction model incorporating prior mammograms, previously validated in Black and White women, could predict future risk of breast cancer across a racially and ethnically diverse population in a population-based screening program.

DESIGN, SETTING, AND PARTICIPANTS: This prognostic study included women aged 40 to 74 years with 1 or more screening mammograms drawn from the British Columbia Breast Screening Program from January 1, 2013, to December 31, 2019, with follow-up …

Switching On The Evolutionary Potential Of Pancreatic Cancer: The Tumor Suppressor Functions Of Pbrm1, Luigi Perelli, Giannicola Genovese

Faculty, Staff and Student Publications

Cell plasticity is a hallmark of cancer, enabling tumor cells to acquire multiple phenotypes responsible for tumor progression, metastasis, and therapy resistance. In this issue of the JCI, Kawai and colleagues leveraged genetically engineered mouse models (GEMM) of pancreatic ductal adenocarcinoma (PDAC) to demonstrate that loss of Pbrm1, a member of the SWI/SNF complex, drives dedifferentiation and aggressive tumor features. Pbrm1 loss activated a program of epithelial-to-mesenchymal transition (EMT) and allowed the emergence of poorly differentiated histologies that are commonly associated with high recurrence rate and dismal prognosis. These findings reveal the role of the SWI/SNF complex during PDAC evolution …

Harnessing Electrophiles In Vivo: A Pilot Study In Swine Using A Hydrophobic Radiopaque Formulation Of 2-Propylpentanoyl Chloride, Erik Cressman, Danielle Stolley, Natalie Fowlkes, Edd Felix, Waldemar Priebe, David Fuentes

Faculty, Staff and Student Publications

Manipulating biology through chemistry is older than the discipline of chemistry itself. Traditionally, selectivity of oral or intravenous drugs relied on preferential drug-receptor binding. A novel approach exploiting image-guided techniques to impart spatial selectivity opens up a wide range of new possibilities for study and manipulation of biology. Motivated initially by the poor prognosis for solid tumors such as liver cancer, we demonstrate the use of an extreme form of in vivo chemistry for targeted delivery of 2-propylpentanoyl chloride in a swine model. The ensuing reaction in tissue devitalizes it by multiple mechanisms with lasting effects and, critically, demonstrates very …

Mutation Of Smarca4 Induces Cancer Cell-Intrinsic Defects In The Enhancer Landscape And Resistance To Immunotherapy, Yawen Wang, Ismail M Meraz, Md Qudratullah, Sasikumar Kotagiri, Yanyan Han, Jing Wang, Jack A Roth, Yonathan Lissanu

Faculty, Staff and Student Publications

Cancer genomic studies have identified frequent alterations in genes encoding components of the SWI/SNF chromatin remodeling complex, including SMARCA4 and ARID1A. Importantly, clinical reports indicate that SMARCA4-mutant lung cancers respond poorly to immunotherapy and have dismal prognosis. In this study, we corroborated the clinical findings by using immune-humanized, syngeneic, and genetically engineered mouse models of lung cancer harboring SMARCA4 deficiency. Specifically, models with SMARCA4 loss showed decreased response to anti-PD-1 immunotherapy associated with significantly reduced infiltration of dendritic cells and CD4+ T cells into the tumor microenvironment. SMARCA4 loss in tumor cells led to profound downregulation of STING1, IL1β, and …

Drosha: A New Tumor Suppressor In Pineoblastoma, Zhixuan Huang, Xueli Ren, Jian Hu

Faculty, Staff and Student Publications

In this Outlook, Huang et al. discuss a study in this issue of Genes & Development by Fraire et al. that shows that a deficiency in miRNA processors Drosha and Dicer and consequent cell cycle gene derepression promote pineoblastoma development. The authors highlight the heterogeneity of pineoblastoma's pathogenic mechanisms and its implications for therapeutic interventions in the clinic.

Automated Task Management In A Cloud-Based Workspace, Ilia Labzovsky, Danny Karmon

Defensive Publications Series

A technique is proposed for automated task management in a cloud-based workspace. Content corresponding to an intended task pertaining to a user is identified from a set of electronic documents associated with the user. A task plan for the intended task is generated based on the set of electronic documents and/or one or more additional electronic documents associated with the intended task. An indication of a sequence of operations of the task plan is provided for presentation via a user interface (UI) of a client device associated with the user. A user-initiated instruction from the client device is received to …

Shaping A Sustainable Future: The Transformative Potential Of Merging Design Thinking With Futures Thinking For Environmental Impact, Christina Fam Neseem, Rehab Elhebary, Salwa Al-Gharibe

Journal of Art, Design and Music

This paper aims to understand how combining Design Thinking with Futures Thinking could foster environmental innovation and assist in developing a sustainable future. When the world faces such serious environmental challenges, the combination of the two methodoloies will be a strategic approach to attaining sustainable results. Consequently, Design Thinking that is mainly focused on human-centered solutions and Futures Thinking that is all about long-term vision when applied together create a solid structure for the present and future environmental challenges. The paper explores the typologies, the main conceptual components, and the methodologies that are associated with both approaches, demonstrating how combined …

Novel Fashion Designs Using Interactive Programming, Manal M.T. Al-Adawy, Salah A. Aly, Islam G. Khalaf, Norhan E. Nagdy

Journal of Art, Design and Music

This research aims to use mathematical equations and interactive programming to create new fashion designs and to measure the extent to which artificial intelligence and, computer programs facilitate the new design and implementation of fashion. To achieve the objectives of the research, certain research tools are built, which are the use of interactive programming such as the Java language to solve mathematical equations that are used in parts of the design, sources of inspiration and colors. The golden ratio method is used to determine the silhouettes used in designs and the use of fashion design programs in drawing designs. The …

Proposing An Integrative Framework For Conducting Empirical Research On Culture-Inspired Product Design, Peter Oluwagbenga Odewole, Michael Abiodun Oyinloye, Johnson Olarinde Oladesu

Journal of Art, Design and Music

In developing African countries, such as Nigeria, the intersection of culture and product design poses a multifaceted challenge that demands comprehensive investigation. The existing body of research needs an integrative framework that adequately addresses the intricate dynamics involved in culture-inclined product design processes within these specific socio-economic and cultural contexts. This deficiency hampers the ability of designers, researchers, and policymakers to develop effective strategies for creating products that resonate with their diverse cultural heritage. Using a qualitative research method based on secondary data, this study develops an integrative framework for conducting empirical research on culture-inspired product design focusing on Nigeria, …

The Impact Of Employing Quantum Art On The Efficiency Of The Ready-Made Garment Industry And Its Application To Football Sportswear, Kholoud Yassin Ali Sabbah, Amr Gamal El-Din Hassouna, Naglaa Mohammed Teama, Kariman Ali Bek Abdelrahman

Journal of Art, Design and Music

This research investigates the potential of quantum art Color Physics to revolutionize the design process of ready-made garment. By examining its application to football sportswear, we aim to evaluate the efficiency gains, innovative design possibilities, and overall impact of this emerging technology on the ready-made garment industry. This is done by studying the analysis of the physical efficiency of a football player when wearing the official uniform of the national team or club he plays for, through devices to measure physical efficiency and modern applications to provide results, heat maps, and data related to the level of efficiency of the …

The Role Of Artificial Intelligence In Optimising Interior Design Outcomes, Asmaa Awad Aly Abo Meddain

Journal of Art, Design and Music

This research explores the transformative role of Artificial Intelligence (AI) in interior design education, focusing on the impact of AI rendering tools on student creativity, learning efficiency, and the development of future-oriented skills. Using a case study methodology, the study evaluates student experiences with three prominent AI rendering platforms. The findings indicate that AI tools significantly enhance students' abilities to visualize, iterate, and experiment with design concepts, leading to improved design outcomes by broadening their creative horizons and expediting the design process. However, challenges related to rendering accuracy and tool usability were identified, highlighting the need for a balanced integration …

A Brief Introduction To Computational Design Terminologies And Concepts, Ahmed Mostafa Mohamed El Shazly, Fatheya Sobhy Matuk, Mona Mahmoud Shams El Din

Journal of Art, Design and Music

Computational design is often presented in purely technical terms without understanding the underlying logic and theory behind the process. Computational design is defined as the application of computational strategies to the design process. While designers traditionally rely on intuition and experience to solve design problems, computational design aims to enhance this process by encoding design decisions using computer language. The goal is not necessarily to document the final result, but rather the steps required to create that result. Computational design draws inspiration from nature's ability to create efficient designs that exhibit complexity, organic forms and natural patterns. It enables designers …

Fostering Collaborative Innovation By Bridging The Engineering-Design Gap In Egypt: Hcd&E Integration And Visionary Design With Ai Integration In Education, Ahmed T.M. Fathy, Salwa El Ghareeb, Yasser Shaban

Journal of Art, Design and Music

This paper addresses a key challenge in Egypt's Educational sector: the mismatch between engineering education and the needs of modern design-focused companies. This gap hinders the development of user-friendly products and the sector's competitiveness. To bridge this divide, the paper proposes collaborative design training for engineers and designers. This paper will equip them with Human-Centered Design and Engineering and VisionaryDriven Design Research skills. By understanding user needs and developing solutions for the future, engineers can create a stronger link between education and industry. The paper will explore specific points to improve collaboration between engineers and designers, the potential of artificial …

Mastering The Phases Of Design Strategy: A Comprehensive Guide To Navigating From Conceptualization To Launch In The Digital Product Life Cycle, Mahmoud Ahmed Gouda Elgazzar, Mina Eshaq Tawfilis Dawood

Journal of Art, Design and Music

The initial phase of the digital product life cycle, known as the introduction stage, is undeniably one of the most crucial and challenging periods. It is characterized by an open-ended design process, where ideas are still being explored and refined. This phase also brings about high levels of uncertainty regarding market acceptance, making it essential for companies to foster innovation and experimentation to find the winning formula. Navigating through this early stage presents significant challenges for businesses as they face various obstacles that can impede their success. One prominent obstacle is limited consumer awareness of the new product or service …

Novel Electrospinning Techniques For Fabricating Scaffolds To Model Intracranial Atherosclerotic Disease In Tissue Engineered Blood Vessel Mimics, Isaac "Squeaky" Buentipo

Master's Theses

Novel Electrospinning Techniques for Fabricating Scaffolds to Model Intracranial

Atherosclerotic Disease in Tissue Engineered Blood Vessel Mimics

Isaac “Squeaky” Buentipo

Dr. Kristen Cardinal’s Tissue Engineering Lab at California Polytechnic State University specializes in fabricating customized vascular models, known as Blood Vessel Mimics (BVMs), for medical device testing. BVMs are simplified in vitro vascular models designed to bridge the gap between bench testing and in vivo evaluation of intravascular medical devices. BVMs are produced by combining a polymer scaffold with human vascular cells. Through novel scaffold fabrication techniques, such as silicone injection molding, silicone dip casting and electrospinning, the capabilities of …

Review Of Steve: A Framework For Ai And Identity Design, Maithili Mishra

Book Reviews

No abstract provided.

Evaluation Of Antibiotic Testing Protocols For Biofilm-Forming Escherichia Coli In A Microfluidic Platform, Caleb R. Telander

Master's Theses

Catheter-associated urinary tract infections remain an ongoing clinical problem due to biofilm persistence and antibiotic resistance. Standard antibiotic susceptibility testing cannot accurately reproduce flow conditions and the spatial complexity of the in vivoenvironment and is thus questionable in relevance to device-related infections. This study examines a microfluidic device designed to simulate physiologically relevant wall shear stress and antibiotic gradients in Escherichia coli biofilms. The polydimethylsiloxane-based system integrates a 16-well culture chamber with a gradient generator. Biofilm growth was observed using fluorescence microscopy of green fluorescent protein-labeled bacteria. Simulations performed using COMSOL Multiphysics software estimated the appropriate range of wall …

Why University Libraries Should Not Overlook Research Staff, Bella Ratmelia

Research Collection Library

In a commentary, the uthor noted that university libraries often overlook research staff due to the transitory nature of these roles. She emphasised that these staff are key drivers of research productivity, bringing specialised skills and adaptability to evolving methodologies. To better support them, the author urged libraries to engage research staff through initiatives like SMU’s workshops co-taught by librarians and researchers and the SMU Researcher Club, which fosters their professional and personal growth while building future collaborations across academia and industry

Microplastic Eaters, Alanna Boze

Bioengineering Senior Theses

This thesis evaluated Alcanivorax Borkumensis’ (A. Borkumensis) ability to degrade polystyrene in a pyruvate-rich environment to determine if the bacteria could degrade the microplastic when grown in pyruvate. The thesis explored the metabolic behavior of A. Borkumensis when pyruvate is used to start the gluconeogenesis pathway, which is the start of the metabolic pathway when degradation occurs. The bacterium was grown in ONR7a medium, that was adjusted to a pH of 8.1, and 1% pyruvate; then it was processed by centrifugation and washing before experimentation began. Trials were conducted to iteratively refine the process and verify trial results. Bacterial growth …

Ai-Based Requirements Analysis Assistant That Applies Explicit Knowledge And Includes Humans In The Loop, Steven Alter

Business Analytics and Information Systems

This exploratory paper builds on the EMMSAD 2024 paper “Could a Large Language Model Contribute Significantly to Requirements Analysis?” Eight versions of each of three LLM prompts (for system structure, analysis, and recommendations) were applied to three 3000+ word case studies. Those versions expressed different “treatments” including a control with no RAG augmentation, a version with RAG augmentation based on an analysis template used by MBA and EMBA students, and six other versions based on theoretical approaches such as activity theory, a BPM design space, work system principles, and so on. The LLM responses were somewhat reliable for summarizing system …

Efficacy Of Monophasic And Biphasic Pulsed Field Ablation Waveforms: A Model Study, Natalia Dekock

Master's Theses

Cardiac arrhythmias are conditions where the heart’s normal sinus rhythm is interrupted by accelerated or premature rhythms. The most prevalent of these rhythms is atrial fibrillation (AF), where disorganized impulses cause the atria to quiver and pump blood inefficiently. As of 2025, AF affects over 10 million people. Aside from invasive surgical treatments, antiarrhythmic drugs, or one time cardioversions, atrial fibrillation is treated with catheter ablation. The longstanding ablation solutions for AF have been the cryoballoon or radiofrequency catheter ablation. However, limitations for these two ablation modalities are due to the nature of cell destruction; both thermal methods pose a …

Effect Of Foot Strike Pattern On Joint Kinetics On A Downhill Slope, Evan Manley

Master's Theses

With recent increases in participation in outdoor running events, there is a need for research in downhill gait biomechanics. One change that could impact joint loading is foot strike pattern. Foot strike patterns have been categorized into rearfoot-strike (RFS), midfoot-strike (MFS), and forefoot-strike (FFS) [1]. While 75-99% of distance runners naturally RFS on level surfaces, they tend to move towards FFS when it is necessary to reduce vertical loading conditions at the knee [1]. The purpose of this study was to examine differences in peak vertical knee and ankle forces, knee moment, and ankle power, as well as cumulative force …

Balance Assessment Of Disc Golf Players By A Smartphone, Joshua Paul Kannankunni

Master's Theses

Disc golf is an underrepresented sport in biomechanics research, even though it could have effects on gait and balance. Forward and side lunges performed while throwing discs can improve static and dynamic balance. The purpose of this study was to explore the effects of playing disc golf on various static and dynamic balance metrics. Static and dynamic balance experiments were done on 20 disc golf players and 20 control participants to record their RMS of acceleration during the double leg, tandem, and single leg static poses, as well as their gait speed, cadence, stride length, right step length, left step …