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Articles 46171 - 46200 of 1104556
Full-Text Articles in Entire DC Network
Neural Engineering In Action: Exploring Muscle Movement Through Data And Design, Dr. Ashwin Mohan, Dr. Sowmya Anjur, Mrs. Namrata Pandya, Matthew Stroud, Dr. David Bergin Emeritus, Dr. Satish Nair
Neural Engineering In Action: Exploring Muscle Movement Through Data And Design, Dr. Ashwin Mohan, Dr. Sowmya Anjur, Mrs. Namrata Pandya, Matthew Stroud, Dr. David Bergin Emeritus, Dr. Satish Nair
2025
No abstract provided.
High-Salt Tumor Microenvironment: Not As Bad As It Sounds, Not As Good As It Seems, Umer Ali, Venkataswarup Tiriveedhi
High-Salt Tumor Microenvironment: Not As Bad As It Sounds, Not As Good As It Seems, Umer Ali, Venkataswarup Tiriveedhi
Biology Faculty Research
Recent evidence suggests a high-sodium microenvironment in breast tumors. However, the exact role of this high-sodium microenvironment on tumorigenesis is unknown. Salt (sodium chloride, NaCl) is a well-known inflammatory molecule playing a significant role in various chronic ailments like cardiovascular and autoimmune diseases. Importantly, chronic inflammation is recognized as one of the major hallmarks of carcinogenesis. Breast cancer cell culture-based studies demonstrated that high-salt (HS) treatment (Δ35–50 mM NaCl) induced cancer cell proliferation. However, preclinical murine research showed reduced tumor progression kinetics in mice fed a short-term HS diet (4% NaCl diet, 0–2 weeks prior to the injection of tumor …
Asme, University Of Mississippi. American Society Of Mechanical Engineers. Student Chapter
Asme, University Of Mississippi. American Society Of Mechanical Engineers. Student Chapter
University Website Migration from WordPress
No abstract provided.
Role Of Autonomic Dysfunction In Initiating Postoperative Atrial Fibrillation In A Canine Sterile Pericarditis Model, Seungyup Lee, Don W. Wallick, Celeen Khrestian, Dragan Juzbasich, Daniel Laurita
Role Of Autonomic Dysfunction In Initiating Postoperative Atrial Fibrillation In A Canine Sterile Pericarditis Model, Seungyup Lee, Don W. Wallick, Celeen Khrestian, Dragan Juzbasich, Daniel Laurita
Faculty Scholarship
Background: Autonomic dysfunction plays a significant role in initiating postoperative atrial fibrillation (POAF) by causing atrial ectopic triggers, potentially through mechanisms such as increased sympathetic activity and altered vagal tone. These atrial ectopic triggers can easily induce POAF, especially in the presence of vulnerable substrates such as pericardial inflammation or structural remodeling. Objective: To test the hypothesis that autonomic dysfunction causes atrial ectopic triggers or POAF in the canine sterile pericarditis model. Methods: Ten sterile pericarditis dogs were studied on postoperative Days 2−3. Autonomic dysfunction was induced by stellate ganglion nerve stimulation (SNS, 5–15 mA; 4–10 Hz; pulse width 0.5–5 …
Compliant Mechanisms For Scalable Systems And Precision Deployment, Jared Rodney Hunter
Compliant Mechanisms For Scalable Systems And Precision Deployment, Jared Rodney Hunter
Theses and Dissertations
Compliant mechanisms offer advantages in precision applications where size, scaling, and environmental effects render traditional mechanisms inadequate or likely to fail. However, designing compliant mechanisms and integrating them into larger, more complex systems remains a challenging problem. This thesis presents work that addresses this issue with analytical models and experiments on flat springs, scalable compliant mechanisms, and origami arrays. Storing and releasing energy in tiny, flat compliant mechanisms opens the door for the design of innovative actuators and products in space-constrained situations. Scaling compliant mechanisms allows novel systems to be made that can operate across scales. By designing for scalability …
Accessible And Inclusive Pathways To Higher Education: Outcomes From A Pilot Feasibility Study Of Irish Transition-Year Student Participation With University Pre-College Courses, Susan Lynott, Charlie Cullen, Kevin Mellon
Accessible And Inclusive Pathways To Higher Education: Outcomes From A Pilot Feasibility Study Of Irish Transition-Year Student Participation With University Pre-College Courses, Susan Lynott, Charlie Cullen, Kevin Mellon
Irish Journal of Academic Practice
The TYDE programme is a college-in-school initiative which aims to develop partnerships between Technological University Dublin (TU Dublin) and local schools. It provides second-level students with an authentic experience of what is required to succeed in university programmes within the familiar environment of school. This experience supports students in transitioning from secondary school to university life, encourages participation, and supports good college and career choices. Transition-year students (15–16 year-olds) take core university modules from engineering programmes running at TU Dublin. The students get to experience first-year modules under the same conditions as college students. In this paper we present the …
Talon Industries Llc V. Rolled Metal Products Inc
Talon Industries Llc V. Rolled Metal Products Inc
2025 Decisions
USDC for the District of New Jersey
Human Gut Commensal Alistipes Timonensis Modulates The Host Lipidome And Delivers Anti-Inflammatory Outer Membrane Vesicles To Suppress Colitis In An Il10-Deficient Mouse Model, Ethan Older, Mary K. Mitchell, Andrew Campbell, Xiaoying Lian, Michael Madden, Yuzhen Wang, Lauren E. Van De Wal, Thelma Zaw, Brandon N. Vanderveen, Rodney Tatum, E. Angela Murphy, Yan-Hua Chen, Daping Fang, Melissa Ellermann, Jie Li
Human Gut Commensal Alistipes Timonensis Modulates The Host Lipidome And Delivers Anti-Inflammatory Outer Membrane Vesicles To Suppress Colitis In An Il10-Deficient Mouse Model, Ethan Older, Mary K. Mitchell, Andrew Campbell, Xiaoying Lian, Michael Madden, Yuzhen Wang, Lauren E. Van De Wal, Thelma Zaw, Brandon N. Vanderveen, Rodney Tatum, E. Angela Murphy, Yan-Hua Chen, Daping Fang, Melissa Ellermann, Jie Li
Faculty Publications
Correlative studies have linked human gut microbes to specific health conditions. Alistipes is one such microbial genus negatively linked to inflammatory bowel disease (IBD). However, the protective role of Alistipes in IBD is understudied, and the underlying molecular mechanisms remain unknown. In this study, colonization of Il10-deficient mice with Alistipes timonensis DSM 27924 delays colitis development. Colonization does not significantly alter the gut microbiome composition, but instead shifts the host plasma lipidome, increasing phosphatidic acids while decreasing triglycerides. Outer membrane vesicles (OMVs) derived from Alistipes are detected in the plasma of colonized mice, carrying potentially immunomodulatory metabolites into the …
Effective Adapted Psychotherapy Approaches For Autistic Adults: Perspectives From Clinical Psychologists, Emily Morgan Hilton
Effective Adapted Psychotherapy Approaches For Autistic Adults: Perspectives From Clinical Psychologists, Emily Morgan Hilton
Walden Dissertations and Doctoral Studies
Autistic adults face a high risk of co-occurring mental health challenges, yet standard psychotherapy often fails to meet their unique needs, raising concerns about treatment effectiveness. This qualitative study aimed to understand how clinical psychologists decide on therapeutic approaches and adaptations for their autistic adult clients through three research questions: RQ1: How do clinical psychologists decide on the appropriate therapeutic approach they use with their autistic adult clients? RQ2: How do clinical psychologists decide which adaptations are appropriate to implement in psychotherapy with their autistic adult clients? RQ3: Does the therapeutic approach affect how a clinical psychologist chooses appropriate adaptations …
Ocean Acidification Decreases Molting But Not Survival Of Antarctic Amphipods Djerboa Furcipes, Gondogeneia Antarctica, And Prostebbingia Gracilis, Hannah E. Oswalt, Margaret O. Amsler, Charles D. Amsler, Julie Schram, James B. Mclintock, Paul A. Baker
Ocean Acidification Decreases Molting But Not Survival Of Antarctic Amphipods Djerboa Furcipes, Gondogeneia Antarctica, And Prostebbingia Gracilis, Hannah E. Oswalt, Margaret O. Amsler, Charles D. Amsler, Julie Schram, James B. Mclintock, Paul A. Baker
Faculty, Staff, and Students
Ocean acidification refers to a decrease in the pH of the world’s oceans from the oceanic uptake of human-derived atmospheric CO2. Low pH is known to decrease the calcification and survival of many calcifying invertebrates. Shallow, hard bottom communities along the Western Antarctic Peninsula often have incredibly large numbers of invertebrate mesograzers that shelter on and are mutualists with the dominant brown macroalgae. The common amphipod species Djerboa furcipes, Gondogeneia antarctica, and Prostebbingia gracilis were collected from the immediate vicinity of Palmer Station, Antarctica (64°46′S, 64°03′W) in January–February 2023 and maintained under three different pH treatments simulating ambient conditions (approximately …
Youth Activism And The City: An Urban Political Ecology Of Flooding In Porto Alegre, Brazil, Nadine Lorini Formiga
Youth Activism And The City: An Urban Political Ecology Of Flooding In Porto Alegre, Brazil, Nadine Lorini Formiga
Geography Undergraduate Senior Theses
This thesis examines the catastrophic 2024 flooding in Rio Grande do Sul, Brazil—locally known as "The Flood"—through the lens of young environmental activists' experiences in Porto Alegre. Drawing on urban political ecology, disaster studies, and climate justice frameworks, this research examines how colonial-era urban planning and infrastructure influenced the socio-environmental conditions that led to The Flood, how the disaster affected young activists' relationships with their city, and what climate justice might entail in this context. Through (auto)ethnographic fieldwork conducted from July to August 2024, including semi-structured interviews, participant observation, walk-throughs, and social media analysis, this study engages primarily with Eco …
Engineering Faculty Partner With Udri Staff For Summer Research Projects, University Of Dayton
Engineering Faculty Partner With Udri Staff For Summer Research Projects, University Of Dayton
Blog: The Dayton Engineer
University of Dayton faculty and University of Dayton Research Institute (UDRI) researchers collaborated on research projects this past summer. Two projects were completed by School of Engineering faculty members and were focused on self-healing polymers and lightweight composite aircraft.
Food Environments And Mental Health: Analyzing The Impact Of Fast-Food Availability On U.S. Adults (2011-2016), Nicole Tenner
Food Environments And Mental Health: Analyzing The Impact Of Fast-Food Availability On U.S. Adults (2011-2016), Nicole Tenner
NYMC Student Theses and Dissertations
This study investigates the relationship between the availability of fast food in US territories and mental health outcomes. Utilizing a cross-sectional design, the study examines data from the 2011 and 2016 Behavioral Risk Factor Surveillance System (BRFSS) from the CDC, along with data from the U.S. Department of Agriculture’s Food Environment Atlas. The analysis included a nationally representative sample of 351,823 participants across all 50 US states. Multiple regression models examined the association between fast food availability and two primary mental health outcomes: the number of self-reported poor mental health days and the likelihood of being diagnosed with a depressive …
A Year Of Designing And Revising Instruction With Chatgpt:Leveraging Ai For Information Literacy Instruction Using The Parts Approach, Omer Farooq
Criss Library Faculty Proceedings & Presentations
No abstract provided.
Virtual Reality’S Impact On Tourist Attitudes In Islamic Religious Tourism: Exploring Emotional Attachment And Vr Presence, Eman Alkhalifah, Ramy Hammady, Mahmoud Abdelrahman, Alyaa Darwish, Ella Cranmer, Ons Al-Shamaileh, Aikaterini Bourazeri, Timothy Jung
Virtual Reality’S Impact On Tourist Attitudes In Islamic Religious Tourism: Exploring Emotional Attachment And Vr Presence, Eman Alkhalifah, Ramy Hammady, Mahmoud Abdelrahman, Alyaa Darwish, Ella Cranmer, Ons Al-Shamaileh, Aikaterini Bourazeri, Timothy Jung
All Works
This study explores the integration of immersive technologies, specifically virtual reality (VR), to enhance tourist experiences in the rapidly expanding religious tourism sector. Despite VR’s potential, limited research has examined its impact on religious tourism. This study addresses this gap by investigating the role of emotional attachment in influencing VR presence during pre-, on-site, and postexperiences of VR-mediated religious tourism. A quantitative survey was conducted with 201 respondents who participated in VR religious tourism activities. The empirical analysis, conducted using SPSS and AMOS structural equation modeling (SEM), assessed how VR-mediated religious tourism impacts VR presence and tourist attitudes before actual …
Rethinking “Key-Chain Swap” And Other Decontextualized Algorithm Teaching Practices For Rational Number Learners, Connor B. Desai
Rethinking “Key-Chain Swap” And Other Decontextualized Algorithm Teaching Practices For Rational Number Learners, Connor B. Desai
Education Dissertations
Mathematical literacy is critical in an increasingly data-driven society, yet many students struggle with rational number concepts due to the prevalence of decontextualized algorithmic instruction. This study investigates the impact of targeted professional development (PD) on sixth-grade teachers’ instructional strategies and their students’ rational number achievement. The research examines whether explicit, conceptually grounded teaching of rational number operations improves student understanding compared to traditional algorithm-based instruction. Using a mixed-methods approach, the study collected quantitative and qualitative data from students at two middle schools. The intervention was statistically significant at School A, where students in the intervention group demonstrated greater achievement …
Cinematic Dialogue Capture With Mobile Wireless Microphones: A Systems Approach To Blocking, Acoustics, And Set Dynamics, John Trevino
Cinematic Dialogue Capture With Mobile Wireless Microphones: A Systems Approach To Blocking, Acoustics, And Set Dynamics, John Trevino
Theatre Faculty Publications
This paper presents a systems-engineering analysis of cinematic dialogue capture using mobile wireless microphones. Building on field observations and workstation-based evaluation conducted between June and August 2025, the study models the acoustic, timing, and blocking interactions that shape production-sound outcomes on narrative film sets. A multi-layer framework is proposed that integrates sound recording, cinematography, actor movement, and post-production requirements. Results indicate that mobile microphone systems, when operated within disciplined workflows, can deliver high-quality dialogue coverage with notable advantages in mobility, scene flexibility, and production efficiency.
Towards A Robust Hydrologic Data Assimilation System For Hurricane-Induced River Flow Forecasting, Peyman Abbaszadeh, Fatemah Gholizadeh, Keyhan Gavahi, Hamid Moradkhani
Towards A Robust Hydrologic Data Assimilation System For Hurricane-Induced River Flow Forecasting, Peyman Abbaszadeh, Fatemah Gholizadeh, Keyhan Gavahi, Hamid Moradkhani
Civil and Environmental Engineering Faculty Publications and Presentations
The Hybrid Ensemble and Variational Data Assimilation framework for Environmental Systems (HEAVEN) is a method developed to enhance hydrologic model predictions while accounting for different sources of uncertainties involved in various layers of model simulations. While the effectiveness of this data assimilation in forecasting streamflow has been proven in previous studies, its potential to improve flood forecasting during extreme events remains unexplored. This study aims to demonstrate this potential by employing HEAVEN to assimilate streamflow data from United States Geological Survey (USGS) stations into a conceptual hydrologic model to enhance its capability to forecast hurricane-induced floods across multiple locations within …
Unh Leadership Visits Armi, Boys & Girls Clubs Of Greater Manchester, Amy Slattery
Unh Leadership Visits Armi, Boys & Girls Clubs Of Greater Manchester, Amy Slattery
UNH Today Archive
No abstract provided.
Enhancing Dementia Classification For Diverse Demographic Groups: Using Vision Transformer-Based Continuous Scoring Of Clock Drawing Tests., Mengyao Hu, Yi Lu Murphey, Tian Qin, Edmundo R Melipillán, Laura B Zahodne, Richard Gonzalez, Vicki A Freedman
Enhancing Dementia Classification For Diverse Demographic Groups: Using Vision Transformer-Based Continuous Scoring Of Clock Drawing Tests., Mengyao Hu, Yi Lu Murphey, Tian Qin, Edmundo R Melipillán, Laura B Zahodne, Richard Gonzalez, Vicki A Freedman
Faculty, Staff and Student Publications
Objectives: Alzheimer's disease and related dementias significantly affect older adults' quality of life. The clock-drawing test (CDT) is a widely used dementia screening tool due to its ease of administration and effectiveness. However, manual CDT-coding in large-scale studies can be time-intensive and prone to coding errors and is typically limited to ordinal responses. In this study, we developed a continuous CDT score using a deep learning neural network (DLNN) and evaluated its ability to classify participants as having dementia or not.
Methods: Using a nationally representative sample of older adults from the National Health and Aging Trends Study (NHATS), we …
Modeling And Simulation Of Tensegrity Structures With Continuous Cables, Austin R. Brown
Modeling And Simulation Of Tensegrity Structures With Continuous Cables, Austin R. Brown
Theses and Dissertations
This thesis presents a novel approach for modeling and simulating tensegrity structures with continuous cables. A Python-based simulation framework package was developed to address limitations in existing tensegrity modeling software, particularly the inability to model cables passing through multiple nodes. The framework utilizes virtual work methods to solve for equilibrium configurations of 2D, 2.5D and 3D tensegrity systems. Key features include: • A YAML-based input system for easy definition of tensegrity topologies. • Algorithms for handling continuous cables spanning multiple nodes. • Optimization techniques to find stable equilibrium states. • Capability to simulate 2.5D structures wrapped around cylindrical surfaces. • …
Neat Vs. Scruffy: How Early Ai Researchers Classified Epistemic Cultures Of Knowledge Representation, Lindsay Poirier
Neat Vs. Scruffy: How Early Ai Researchers Classified Epistemic Cultures Of Knowledge Representation, Lindsay Poirier
Statistical and Data Sciences: Faculty Publications
Accounts of the history of symbolic artificial intelligence (AI) often categorize researchers and their programs through binary oppositions: logicist versus procedural, or alternatively, neat versus scruffy. These terms were often referenced throughout the 1970s and 1980s by AI researchers at institutions in the United States and Europe to document epistemic and esthetic differences in approaches to knowledge representation. In this article, I historicize and situate these binary oppositions, showing how researchers leveraged them in discourse to demarcate the beliefs and commitments underpinning certain AI approaches. I argue that the labels helped knowledge representation scholars identify, trouble, and grapple with the …
Leveraging An Arts-Based Approach To Foster Engagement, Nurture Kindness, And Prevent Violence, Yok-Fong Paat, Diego Garcia Tovar, Nathan W. Myers, Max C. E. Orezzoli, Anne M. Giangiulio, Sarah L. Ruiz, Angela V. Dorado, Luis R. Torres-Hostos
Leveraging An Arts-Based Approach To Foster Engagement, Nurture Kindness, And Prevent Violence, Yok-Fong Paat, Diego Garcia Tovar, Nathan W. Myers, Max C. E. Orezzoli, Anne M. Giangiulio, Sarah L. Ruiz, Angela V. Dorado, Luis R. Torres-Hostos
School of Social Work Faculty Publications
Drawing from the insights of community partners, this study explored the roles and benefits of arts-based approaches to foster civic learning, critical media literacy, and community engagement. It also uncovered approaches to promote kindness, prevent violence, and combat online extremism, offering insights into strategies that may enhance community engagement and create a positive impact. We presented our model framework, a detailed case study of our project, and qualitative methods incorporating 15 interviews with our community partners to capture a broad range of perspectives and experiences. Interviewees were community partners who collaborated with our project in organizing events and activities using …
A Veblenian Approach To Chaos Theory, Isaiah Henry
A Veblenian Approach To Chaos Theory, Isaiah Henry
Hatfield Graduate Journal of Public Affairs
This paper provides a comparative analysis of Veblen's belief in disequilibrium, the field of chaos theory, and how these two frameworks connect. We explore the similarities and differences between Veblen's theories and the principles of chaos theory, including their shared emphasis on complexity and unpredictability. By analyzing the connections between Veblen's economic theories and chaos theory, we can gain a deeper understanding of the nature of disequilibrium and the complex forces that shape our world.
One Health Integration To Control And Prevent Zoonoses: Application Of Organizational Theory Literature, Lisset M. Dumet Poma, Sherril Gelmon, Julia M. Goodman, Seth E. O’Neal
One Health Integration To Control And Prevent Zoonoses: Application Of Organizational Theory Literature, Lisset M. Dumet Poma, Sherril Gelmon, Julia M. Goodman, Seth E. O’Neal
Hatfield Graduate Journal of Public Affairs
Zoonoses are infectious diseases transmitted between animals and people that disproportionately affect low- and middle-income countries (LMICs). The One Health (OH) approach aims to integrate systems, incentivizing collaboration among animal, human, and environmental systems to address zoonoses and improve health. Innovative solutions for effectively and sustainably achieving systems integration are needed. Organizational theories can facilitate the study of the context of OH implementation, applying comprehensive approaches that recognize the interconnections among organisms, the environment, and social systems, including the diverse entities needing integration (e.g., policy, community, public organizations). This narrative review examines organization and systems literature to provide recommendations for …
Re: Comment Letter For Butte Priority Soils Operable Unit (Bpsou) Superfund Operation And Maintenance (O&M) Request For Maintenance – Kelley Stormwater Channels (Dated April 22, 2025), Emma Rott
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Structural Basis For The Substrate Specificity Of Helix Pomatia Amp Deaminase And A Chimeric Adgf Adenosine Deaminase, Gundeep Kaur, John R Horton, George Tzertzinis, Jujun Zhou, Ira Schildkraut, Xiaodong Cheng
Structural Basis For The Substrate Specificity Of Helix Pomatia Amp Deaminase And A Chimeric Adgf Adenosine Deaminase, Gundeep Kaur, John R Horton, George Tzertzinis, Jujun Zhou, Ira Schildkraut, Xiaodong Cheng
Faculty, Staff and Student Publications
Helix pomatia AMP deaminase (HPAMPD), an enzyme enriched in the foot muscle of the mollusk H. pomatia, exhibits deaminase activity on adenosine-5'-monophosphate (AMP). HPAMPD is the first member of the adenosine deaminase-related growth factor (ADGF) family to prefer the nucleotide AMP over the nucleoside adenosine. To investigate the substrate selectivity of HPAMPD, we determined its structure in both the apo form and in complex with the adenosine analogs pentostatin and pentostatin-5'-monophosphate. Structurally, HPAMPD adopts a fold similar to human ADA2, an ADGF family member. HPAMPD has acquired the ability to interact with the 5'-monophosphate group of AMP through polar and …
Pluriversal Energy Justice Through An Intersectional Feminist Lens: Analyzing Rural Electrification Injustices And Policy Pathways At Kenya's Garissa Solar Park, Carolyne M. Musyoka
Pluriversal Energy Justice Through An Intersectional Feminist Lens: Analyzing Rural Electrification Injustices And Policy Pathways At Kenya's Garissa Solar Park, Carolyne M. Musyoka
Dartmouth College Master’s Theses
Located approximately 4 km from Raya village in Garissa County, the Garissa Solar Park spans
85 hectares and was envisioned as a flagship renewable energy project. Yet, despite its scale and proximity, the marginalized pastoralist community of Raya continues to face acute energy poverty, limited irrigation capacity, and exclusion from the material and socio-ecological benefits of the green energy project. This study critically examines the systemic energy injustices embedded within the Garissa Solar Park—specifically procedural, distributive, and recognition-based inequalities—and critiques the project’s failure to deliver on principles of equity, local meaningful and democratic participation, and gender inclusion.
The research assesses …
Engineering Lipid–Polymer Nanoparticles For Sirna Delivery To Cancer Cells, Arthur Manda, Abdulelah Alhazza, Hasan Uludağ, Hamidreza Montazeri Aliabadi
Engineering Lipid–Polymer Nanoparticles For Sirna Delivery To Cancer Cells, Arthur Manda, Abdulelah Alhazza, Hasan Uludağ, Hamidreza Montazeri Aliabadi
Pharmacy Faculty Articles and Research
Background: RNA interference (RNAi) is a powerful tool that can target many proteins without the expensive and time-consuming drug development studies. However, due to the challenges in delivering RNA molecules, the potential impact of RNAi approaches is yet to be fully realized in clinical settings. Lipid nanoparticles (LNPs) have been the most successful delivery system for nucleic acids, but targeted delivery to a solid tumor still eludes the developed LNPs. We hypothesized that specially designed low-molecular-weight PEIs can partially or completely replace the ionizable lipids for more accommodating vehicles due to the structural flexibility offered by polymers, which could …
A Library Of Lineage-Specific Driver Lines Connects Developing Neuronal Circuits To Behavior In The Drosophila Ventral Nerve Cord, Jelly H M Soffers, Erin Beck, Daniel J Sytkowski, Marianne E Maughan, Devasri Devarakonda, Yi Zhu, Beth A Wilson, Yu-Chieh David Chen, Ted Erclik, James W Truman, James B Skeath, Haluk Lacin
A Library Of Lineage-Specific Driver Lines Connects Developing Neuronal Circuits To Behavior In The Drosophila Ventral Nerve Cord, Jelly H M Soffers, Erin Beck, Daniel J Sytkowski, Marianne E Maughan, Devasri Devarakonda, Yi Zhu, Beth A Wilson, Yu-Chieh David Chen, Ted Erclik, James W Truman, James B Skeath, Haluk Lacin
2020-Current year OA Pubs
Understanding developmental changes in neuronal lineages is crucial to elucidate how they assemble into functional neural networks. Studies investigating nervous system development in model systems have only focused on select regions of the CNS due to the limited availability of genetic drivers that target specific neuronal lineages throughout development and adult life. This has hindered our understanding of how distinct neuronal lineages interconnect to form neuronal circuits during development. Here, we present a split-GAL4 library composed of genetic driver lines, which we generated via editing the genomic locus of lineage-specific transcription factors and demonstrate that we can use this library …